Baron S, editor. Medical Microbiology. 4th edition. Galveston (TX): University of Texas Medical Branch at Galveston; 1996. Available from: NCBI Books Wikipedia P.Gingivalis genome project
Host pathogen interactomes for :Bornavirus; Borrelia Burgdorferi; Candida albicans; Chlamydia Pneumoniae ; Cryptococcus Neoformans; Ebola virus; Epstein-Barr virus; Helicobacter pylori; Hepatitis C virus; Herpes simplex (HSV-1); HERV-W; HIV-1, Human Protein Interaction Database (NCBI); Human cytomegalovirus; Influenza A virus; Toxoplasma Gondii; Trypanosoma Cruzi : KEGG pathway analysis of these interactomes can be accessed here

 

 

 

Host proteins used by Porphyromonas gingivalis during its life cycle. KEGG pathways of this interactome

If you know of other interactions, (or corrections) please with Pubmed ID, gene symbol/accession number and interacting protein. Thank you.

  1. ABCA1: P. gingivalis LPS treatment caused an increase in CD36 mRNA and protein levels, and a decrease in ABCA1 mRNA and protein levels in THP-1-derived macrophages Li et al, 2013
  2. ADORA2A adenosine A2a receptor: P. gingivalis may use ADORA2A coupled danger signal adenosine signaling as a means to establish successful persistence in the oral mucosa Spooner et al, 2014
  3. AGER receptor for advanced glycation end-products: P. gingivalis infection enhanced expression of RAGE in Murine aortic endothelial cells Pollreisz et al, 2010
  4. AIM2 absent in melanoma 2: P.Gingivalis activates the AIM2 and NLRP3 inflammasomes Park et al, 2014
  5. AKT1. AKT serine/threonine kinase 1: P. gingivalis, reduces Akt phosphorylation in gingival epithelial cells Nakayama et al, 2015
  6. ANGPT1 angiopoietin 1: inhibited by P. gingivalis Zhang et al, 2015
  7. ANGPT2 angiopoietin 2: P. gingivalis upregulated the expression of Angpt2 and its transcription factor ETS1 Zhang et al, 2015
  8. APAF1 apoptotic peptidase activating factor 1: P. Gingivalis increases APAF1 expression in Oxidised-LDL pre-treated endothelial cells Bugueno et al, 2016
  9. APC Axin1, adenomatous polyposis coli (APC), and GSK3ß proteolytically processed by P. gingivalis gingipains Zhou et al, 2015
  10. APLP1 amyloid beta precursor like protein 1 : gene expressions of APP, APLP1, and APLP2 in HGFs all increased after being treated with P. gingivalis LPS in human gingival fibroblasts Wei et al, 2016
  11. APP amyloid beta precursor protein: P.gingivalis infection increases beta-amyloid deposition in the cortex and hippocampus in transgenic APP mice (Swedish mutation) Ishida et al, 2013. Chronic systemic exposure to bacterial LPS for five consecutive weeks induced learning and memory deficits with the intracellular accumulation of beta-amyloid in neurons in middle-aged wild-type mice Wu et al, 2017
  12. APOB apolipoprotein B cleaved by the bacterial gingipain Bengtsson et al, 2008
  13. ATG5 autophagy related 5: P. gingivalis activated LC3I-II (MAP1LC3A) conversion and increased the conjugation of ATG5-ATG12 and the expression of Beclin1 in THP-1-derived macrophages Park et al, 2016.
  14. ATG12 autophagy related 12: P. gingivalis activated LC3I-II (MAP1LC3A) conversion and increased the conjugation of ATG5-ATG12 and the expression of Beclin1 in THP-1-derived macrophages Park et al, 2016.
  15. AXIN 1: Axin1, adenomatous polyposis coli (APC), and GSK3ß proteolytically processed by P. gingivalis gingipains Zhou et al, 2015
  16. BAD BCL2 associated agonist of cell death: P. gingivalis infection caused significant progressive phosphorylation of BAD while messenger RNA levels for Bad slowly decreased in gingival epithelial cells Yao et al, 2010
  17. BAX BCL2 associated X protein: P.Gingivalis increased expression of pro-apoptotic genes including caspases-1,-3,-9, Bax and decreased expression of anti-apoptotic Bcl2 in Human umbilical vein endothelial cells Bugueno et al, 2016
  18. BCL2 B-cell CLL/lymphoma 2: P.Gingivalis increased expression of pro-apoptotic genes including caspases-1,-3,-9, Bax and decreased expression of anti-apoptotic Bcl2 in Human umbilical vein endothelial cells Bugueno et al, 2016
  19. BECN1 Beclin 1: P. gingivalis activated LC3I-II (MAP1LC3A) conversion and increased the conjugation of ATG5-ATG12 and the expression of Beclin1 in THP-1-derived macrophages Park et al, 2016.
  20. BID BH3 interacting domain death agonist: P. gingivalis stimulated an increase in FOXO1 and FOXO3 mRNA, and of (keratin-1, -10, -14, and involucrin, BID and TRADD and reduced mRNA levels of genes TLR-2 and TLR4) and reduced those associated with barrier function (integrin beta-1, -3 and -6) in gingival epithelial cells Li et al, 2013.
  21. C3 complement component 3 P. gingivalis fixes complement component 3 and adheres to red blood cells via CR1 Belstrøm et al, 2011
  22. C5 complement component 5 : C3 and C5 activated by P.gingivalis gigipain Wingrove et al, 1992
  23. C5AR1 complement component 5a receptor 1 : P. gingivalis vesicles cleave the C5a receptor on human neutrophils Jagels et al, 1996.
  24. CAMP cathelicidin antimicrobial peptide: effective against P.gingivalis Guthmiller et al, 2001
  25. CASP1 caspase 1 : P.Gingivalis increased expression of pro-apoptotic genes including caspases-1,-3,-9, Bax-1 and decreased expression of anti-apoptotic Bcl2 in Human umbilical vein endothelial cells Bugueno et al, 2016
  26. CASP3 caspase 3: P.Gingivalis increased expression of pro-apoptotic genes including caspases-1,-3,-9, Bax and decreased expression of anti-apoptotic Bcl2 in Human umbilical vein endothelial cells Bugueno et al, 2016
  27. CASP8 caspase 8: The surrounding medium of periodontal pathogen P. gingivalis increased DNA fragmentation, nuclear condensation and the activated apoptotic caspase-3, -8, and -9 proteins in H9c2 cardiac cells Lee et al, 2008
  28. CASP9 Caspase 9: P.Gingivalis increased expression of pro-apoptotic genes including caspases-1,-3,-9, Bax and decreased expression of anti-apoptotic Bcl2 in Human umbilical vein endothelial cells Bugueno et al, 2016
  29. CCL5 C-C motif chemokine ligand 5 (RANTES): Cleaved by P. gingivalis gingipain Klarström Engström et al, 2015
  30. CCL25 C-C motif chemokine ligand 25 (teck):expression increased in gingival epithelial cells exposed to P. gingivalis LPS.Usui et al, 2016
  31. CCR5 C-C motif chemokine receptor 5: upregulated by P. gingivalis in oral keratinocytes Giacaman et al, 2007
  32. CD14 receptor for P.Gingivalis lipopolysaccharide Watanabe et al, 1996
  33. CD33 Sialic acid on P.gingivalis LPS (ATCC 33277 strain) binds to CD33 although this interaction can be blocked by endogenous sialic acid on the surface of THP-1 Leukemic monocyte cells Zaric et al, 2017
  34. CD36 Porphyromonas gingivalis lipopolysaccharide increases lipid accumulation by affecting CD36 and ABCA1 in macrophages Li et al, 2013.
  35. CD46, CD55, and CD59 gene expression increased in human oral epithelial cells by lipopolysaccharide from P.gingivalis and other oral pathogens Mahtout et al, 2011
  36. CD209 (DC-SIGN) engaged by P.Gingivalis in dendritic cells El-Awady et al, 2015
  37. CDH1 cadherin 1 occludin, E-cadherin, and beta1-integrin are degraded in lysates derived from MDCK cells exposed to P. gingivalis Katz et al, 2000
  38. CDH2 cadherin 2 : degraded by P. gingivalis gingipain Sheets et al, 2005
  39. CDH5 cadherin 5: degraded by P. gingivalis gingipain Sheets et al, 2005
  40. CEBPB CCAAT/enhancer binding protein beta : expression increased by bacterial LPS in human periodontal ligament cells Bai et al, 2016
  41. CFL1 Cofilin 1: P. gingivalis infection dephosphorylates cofilin in gingival epithelial cells Moffat et al, 2012
  42. CLTA clathrin light chain A: a gingipain derived peptide binds to CLTA and P.gingivalis endocytosis is clathrin dependent also involves clathrin heavy chain CLTC Boisvert et al, 2008
  43. CR1 complement component 3b/4b receptor 1 (Knops blood group): P. gingivalis fixes complement component 3 and adheres to red blood cells via CR1 Belstrøm et al, 2011
  44. CR3 complement receptor 3 (integrins ITGAM/ITGB2) activated CR3 interacts with P. gingivalis fimbriae Hajishengallis and Harokopakis , 2007
  45. CTNNB1 catenin beta 1:activated by the pathogen Zhou et al, 2015
  46. CTSB cathepsin B: Chronic systemic exposure to bacterial LPS increased the expression of CTSB in both microglia and neurons in middle-aged WT mice,Wu et al, 2017
  47. CXCL8 and CXCL10 are processed by P/Gingivalis gingipains Moelants et al, 2014
  48. DEFA1/ DEFA1B (HNP-1) defensin alpha 1 and 1B : DEFB103B (HBD3), HNP-2 (DEFA1), and HNP-1 bind to immobilized P. gingivalis rHagB Dietrich et al, 2008
  49. DDIT3 DNA damage inducible transcript 3 (chop): EIF2AK3 (PERK), eIF2a, HSPA5 (GRP78/Bip), and DDIT3 expression increased by bacterial LPS in human periodontal ligament cells Bai et al, 2016.
  50. DEFB103B defensin beta 103B: binds to a bacterial adhesin Pingel at al, 2008
  51. DNMT1 DNA (cytosine-5-)-methyltransferase 1 : DNMT1 and histone deacetylase (HDAC1 HDAC2 ) expression were decreased in gingival epithelial cells treated with P.gingivalis: Expression of DEFB4A and CCL20 was significantly increased in GECs in response to both P. gingivalis and F. nucleatumYin and Chung, 2011
  52. ECE1 endothelin converting enzyme 1: P. gingivalis lipopolysaccharide inhibitory effect on salivary mucin synthesis is accompanied by a marked increase in EDN1generation and the enhancement in ECE1 activity Slomiany et al, 2004
  53. EDN1 endothelin 1: P. gingivalis lipopolysaccharide inhibitory effect on salivary mucin synthesis is accompanied by a marked increase in EDN1generation and the enhancement in ECE1 activity Slomiany et al, 2004
  54. EEA1 early endosome antigen 1: P. gingivalis is internalized with early endosomes positive for the FYVE domain of EEA1 and transferrin receptor, TFRC in immortalized human gingival epithelial cellsTakeuchi et al, 2011
  55. EGF epidermal growth factor: inactivated by a bacterial enzyme Pyrc et al, 2014
  56. EIF2A eukaryotic translation initiation factor 2A: EIF2AK3 (PERK), eIF2a, HSPA5 (GRP78/Bip), and DDIT3 expression increased by bacterial LPS in human periodontal ligament cells Bai et al, 2016.
  57. EIF2AK3 eukaryotic translation initiation factor 2 alpha kinase 3 (perk) P. gingivalis LPS induces endoplasmic reticulum stress in human periodontal ligament cells Bai et al, 2016
  58. ENO1 enolase 1: Peptidylarginine deiminase from P.gingivalis citrullinates human fibrinogen and ENO1 Wegner et al, 2010
  59. ETS1 ETS proto-oncogene 1, transcription factor: P. gingivalis upregulated the expression of Angpt2 and its transcription factor ETS1 Zhang et al, 2015
  60. EXOC2 exocyst complex component 2: Dominant negative forms and RNAi knockdown of Rab11, RalA and exocyst complex subunits (EXOC2, EXOC3 and EXOC8) significantly disturbed the exit of P. gingivalis from immortalized human gingival epithelial cellsTakeuchi et al, 2011
  61. F2R coagulation factor II thrombin receptor: cleaved by bacterial gingipain Giacaman et al, 2009
  62. F2RL1 F2R like trypsin receptor 1: cleaved by bacterial gingipain Giacaman et al, 2009
  63. F12 coagulation factor XII (Hageman factor): F12, KNG1, KLKB1 and absorbed to the cell surface of P.gingivalis Rapala-Kozik et al, 2011
  64. FASLG Fas ligand: P. gingivalis can induce epithelial cell apoptosis through Fas-FASLG up-regulation and activation of caspase-3 and caspase-8 Brozovic et al, 2006.
  65. FN1 fibronectin 1: P. gingivalis W12 binds and degrades human plasma fibronectin Lantz et al, 1991
  66. FOXO1 forkhead box O1: P. gingivalis stimulated an increase in FOXO1 and FOXO3 mRNA, and of (keratin-1, -10, -14, and involucrin, BID and TRADD and reduced mRNA levels of genes TLR-2 and TLR4) and reduced those associated with barrier function (integrin beta-1, -3 and -6) in gingival epithelial cells Li et al, 2013.
  67. FOXO3 forkhead box O3 see above Li et al, 2013
  68. FOXO4: P.gingivalis infection induces the dephosphorylation and activation of forkhead box-O (FOXO1, FOXO3 and FOXO4) in gingival epithelial cells (transcription of genes involved in protection against oxidative stress (Cat, Sod2, Prdx3), inflammatory responses (IL1B) and anti-apoptosis (Bcl6) was induced by P.gingivalis Wang et al, 2015
  69. GAPDH glyceraldehyde-3-phosphate dehydrogenase:binds to P. gingivalis fimbriae Sojar and Genco, 2005.
  70. GCG glucagon: Glucagon-like peptide-1 (GLP-1), derived from proglucagon is cleaved by P. gingivalis dipeptidyl peptidase 4.Ohara-Nemoto et al, 2017
  71. GIP gastric inhibitory polypeptide: cleaved by P. gingivalis dipeptidyl peptidase 4.Ohara-Nemoto et al, 2017
  72. GSK3B Axin1, adenomatous polyposis coli (APC), and GSK3ß proteolytically processed by P. gingivalis gingipains Zhou et al, 2015
  73. GYPA glycophorin A (MNS blood group) + GYPB P.Gingivalis receptor on erythtocytes Sakai et al, 2007
  74. HIF1A hypoxia inducible factor 1 alpha subunit : additive effects of P.Gingivalis LPS and hypoxia on NFKB1 and HIF1A activation in periodontal ligament cells followed by an upregulation of IL1B, MMP1, and VEGF expression Gölz et al, 2015
  75. HLA-DRB1 major histocompatibility complex, class II, DR beta 1:patients who have the HLA-DRB1*1501-DQB1*0602 genotype may have an accelerated T cell response to certain periodontopathic bacteria such as P. gingivalis in hyperimmune reactions Takashiba et al, 1999
  76. HMGB1 high mobility group box 1: P.gingivalis attenuates ATP-mediated inflammasome activation and HMGB1 release via expression of a nucleoside-diphosphate kinase Johnson et al, 2015.
  77. HSPA5 heat shock protein family A (Hsp70) member 5: EIF2AK3 (PERK), eIF2a, HSPA5 (GRP78/Bip), and DDIT3 expression increased by bacterial LPS in human periodontal ligament cells Bai et al, 2016.
  78. HTN3 histatin 3: binds to P. gingivalis hemagglutinin B Borgwardt et al, 2014
  79. ICAM1 intercellular adhesion molecule 1: P. gingivalis LPS induced ICAM1 on human gingival fibroblasts Masaka et al, 1999
  80. IFNG interferon, gamma: degraded by P.gingivalis gingipainsYun et al, 1999
  81. IGH immunoglobulin heavy locus: IgG1 and IgG3 are cleaved by gingipain K Vincents et al, 2011
  82. IL6R interleukin 6 receptor degraded by P.gingivalis gingipain Oleksy et al, 1992
  83. IL12A and IL12B cleaved by bacterial proteases Yun et al, 2001
  84. IL33 interleukin 33: P.gingivalis Gingipain-Dependently Enhances IL-33 Production in Human Gingival Epithelial Cells via gingipain Tada et al, 2016.
  85. INS insulin: P.gingivalis LPS stimulates insulin secretion in pancreatic ß cell line MIN6 cells and increases the expression of glucose-6-phosphatase catalytic subunit G6PC and insulin-like 3 INSL3, as well as CD8A, CD14 and ICAM1 Bhat et al, 2014
  86. IRF6 Interferon Regulatory Factor 6: Promotes Keratinocyte Differentiation in Response to P. gingivalis: IRF6 expression was strongly upregulated when human oral epithelial cells were challenged with P. gingivalis. IRF6 acts downstream of IRAK1 to stimulate the expression of IL36G in response to P. gingivalis.Huynh et al, 2017:
  87. ITGA2 integrin subunit alpha 2: ITGA2, ITGB1 and ITGB3 degraded by P.gingivalis gingipain Baba et al, 2001
  88. ITGA3, ITGA4, ITGA5, ITGB3 and ITGB4 upregulated by P.gingivalis in gingival cells Handfield et al, 2008
  89. ITGAL integrin subunit alpha L: (LFA-1=ITGB2)/ITGAL) celular receptor for bacterial fimbriae Ogawa et al, 2002
  90. ITGB1 integrin subunit beta 1: occludin, E-cadherin, and beta1-integrin are degraded in lysates derived from MDCK cells exposed to P. gingivalis Katz et al, 2000.
    1. P. gingivalis fimbriae bind and activate ITGB1 inducing signal transduction via downstream targets (Pyk2=PTK2B), Src, Rac, Arp2/3, FAK=PTK2 and CAS, leading to actin and tubulin rearrangements and bacterial uptake Yilmaz et al, 2002
  91. ITGB2 integrin subunit beta 2: cellular receptor of P. gingivalis fimbriae Takeshita et al, 1998
  92. ITGB3 integrin subunit beta 3: ITGA2, ITGB1 and ITGB3 deghraded by P.gingivalis gingipain Baba et al, 2001
  93. ITGB6 integrin subunit beta 6: P. gingivalis stimulated an increase in FOXO1 and FOXO3 mRNA, and of (keratin-1, -10, -14, and involucrin, BID and TRADD and reduced mRNA levels of genes TLR-2 and TLR4) and reduced those associated with barrier function (integrin beta-1, -3 and -6) in gingival epithelial cells Li et al, 2013.
  94. IVL involucrin: P. gingivalis stimulated an increase in FOXO1 and FOXO3 mRNA, and of (keratin-1, -10, -14, and involucrin, BID and TRADD and reduced mRNA levels of genes TLR-2 and TLR4) and reduced those associated with barrier function (integrin beta-1, -3 and -6) in gingival epithelial cells Li et al, 2013.
  95. KLKB1 kallikrein B1: F12, KNG1, KLKB1 and absorbed to the cell surface of P.gingivalis Rapala-Kozik et al, 2011
  96. KRT1 keratin 1 KRT10 KRT14 P. gingivalis stimulated an increase in FOXO1 and FOXO3 mRNA, and of (keratin-1, -10, -14, and involucrin, BID and TRADD and reduced mRNA levels of genes TLR-2 and TLR4) and reduced those associated with barrier function (integrin beta-1, -3 and -6) in gingival epithelial cells Li et al, 2013.
  97. LPL lipoprotein lipase: activation of TLR2 and TLR2/TLR1 by P. gingivalis LPS is partly due to molecules that are sensitive to LPL Jain et al, 2013
  98. LTF lactotransferrin : inhibits Porphyromonas gingivalis proteinases and has sustained biofilm inhibitory activity Dashper et al, 2012
  99. MIR146A microRNA 146a : upregulated by P.Gingivalis LPS in human periodontal ligament cells Jiang et al, 2015
  100. MMP1 mRNA induced in the P. gingivalis treated human gingival fibroblasts Zhou and Windsor, 2006 More active MMP1, MMP2, MMP3, and MMP14 were detected in the conditioned media from the HGFs treated with the P. gingivalis supernatant.
  101. MMP12 mRNA induced in the P. gingivalis treated human gingival fibroblasts Zhou and Windsor, 2006
  102. MMP15 mRNA induced in the P. gingivalis treated human gingival fibroblasts Zhou and Windsor, 2006
  103. MTOR mechanistic target of rapamycin : degraded by P.gingivalis gingipain Stafford et al, 2013
  104. MUC2 cleaved by a P.gingivalis gingipain van der Post et al, 2013
  105. NLRP2 NLR family, pyrin domain containing 2 : P. gingivalis deregulates the NLRP3 inflammasome complex in Mono-Mac-6 cells by enhancing NLRP3 and down-regulating NLRP2 and PYCARD expression Bostanci et al, 2009
  106. NOD2 nucleotide binding oligomerization domain containing 2: contributes to P.gingivalis-induced bone resorption Prates et al, 2014.
  107. NOS2 nitric oxide synthase 2: P. gingivalis ATCC 33277 can induce NOS2 and inhibit NOS3 expression, and stimulate the release of nitric oxide in human umbilical vein endothelial cells Sun et al, 2010
  108. OCLN occludin: occludin, E-cadherin, and beta1-integrin are degraded in lysates derived from MDCK cells exposed to P. gingivalis Katz et al, 2000.:
  109. PANX1 pannexin 1 : PANX1-hemichannels are an extracellular translocation pathway for P. Gingivalis Nucleoside-diphosphate-kinase Atanasova et al, 2016
  110. PDGFB platelet derived growth factor subunit :P. gingivalis LPS stimulate cellular proliferation and responsiveness to PDGF-BB of cultured human periodontal ligament fibroblasts and upregulates PDGFRB (platelet derived growth factor receptor beta) Takemura et al, 1998
  111. PLAU plasminogen activator, urokinase : the bacterial RgpA-Kgp complex cleaves the inactive zymogens, pro-uPA and plasminogen, yielding active uPA and plasmin Fleetwood et al, 2015
  112. PLG plasminogen: the bacterial RgpA-Kgp complex cleaves the inactive zymogens, pro-uPA and plasminogen, yielding active uPA and plasmin Fleetwood et al, 2015
  113. PPARG peroxisome proliferator activated receptor gamma : mRNA level in HUVECs increased after exposure to P. gingivalis for 1h and its protein level increased at 2h Li et al, 2016.
  114. PYCARD PYD and CARD domain containing: mediates the induction of multiple cytokines by P.gingivalis Taxman et al, 2006.
  115. RAB4A member RAS oncogene family: P. gingivalis in early endosomes recruits VAMP2 and Rab4A Takeuchi et al, 2016
  116. RAB5A TNF augments invasion of P. gingivalis in human gingival epithelial cells through increment of ICAM1 and activation of Rab5 Kato et al, 2014
  117. RAB11A RAB11A, member RAS oncogene family: Dominant negative forms and RNAi knockdown of Rab11, RalA and exocyst complex subunits (Sec5, Sec6 and Exo84) significantly disturbed the exit of P. gingivalisin from immortalized human gingival epithelial cellsTakeuchi et al, 2011
  118. RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1): membrane vesicles secreted by P. gingivalis can enter cells via a Rac1 regulated pinocytic pathway Furuta et al, 2009
  119. RALA RAS like proto-oncogene A: Dominant negative forms and RNAi knockdown of Rab11, RalA and exocyst complex subunits (EXOC2, EXOC3 and EXOC8) significantly disturbed the exit of P. gingivalis from immortalized human gingival epithelial cellsTakeuchi et al, 2011
  120. RARRES2 retinoic acid receptor responder 2: (chemerin) :Inactivated by a P.gingivalis gingipain Godlewska et al, 2017
  121. RELA RELA proto-oncogene, NF-kB subunit: SerB, a haloacid dehalogenase family serine phosphatase secreted by P. gingivalis dephosphorylates S536 of RELA in gingival epithelial cells Takeuchi et al, 2013
  122. RIPK1 P. gingivalis infection of HAEC resulted in the rapid cleavage RIPK1 and RIPK2 Madrigal et al, 2012
  123. S100A8+S100A9 = Calprotectin: Calprotectin expression in vitro by oral epithelial cells confers resistance to infection by P. gingivalis Nisapakultorn et al, 2001
  124. S100A9 S100 calcium binding protein A9 : knockdown (siRNA) attenuated the effect of P. gingivalis on transformation and proliferation of human aortic smooth muscle cells Inaba et al, 2009
  125. SDC1 syndecan 1: P. gingivalis lipopolysaccharide induces shedding of SDC1 expressed by gingival epithelial cells Andrian et al, 2005
  126. SELE selectin E: mediates P. gingivalis adherence to human endothelial cells.Komatsu et al, 2012
  127. SERPINA1 serpin family A member 1 inactivated by P. gingivalis Periodontain Nelson et al, 2009
  128. SIRT1 sirtuin 1: P. Gingivalis LPS upregulates SIRT1 mRNA and protein expression in human periodontal ligament cells Park et al, 2012.
  129. SLAMF7 SLAM family member 7 (CRACC): induced in primary human peripheral blood mononuclear cells by Aggregatibacter actinomycetemcomitans or P.gingivalis Krämer et al, 2013
  130. TAS2R38 taste 2 receptor member 38: Secretion levels of IL1a and IL8 decreased in response to P. gingivalis when T2R38 was silenced in gingival epithelial cells Gil et al, 2015
  131. TF Transferrin: albumin, haemopexin, haptoglobin and transferrin are degraded by P. gingivalis Carlsson et al, 1984.
  132. TIMP1 TIMP metallopeptidase inhibitor 1 : decreased in P. gingivalis treated human gingival fibroblasts Zhou and Windsor, 2006
  133. TIMP2 TIMP metallopeptidase inhibitor 2: P. gingivalis LPS dose-dependently and differentially modulated the expression of MMP-1, 2, and 3 and TIMP1 and TIMP2 in human gingival fibroblastsBozkurt et al, 2017
  134. TLR1 P. gingivalis LPS activates both TLR2 combined with TLR1 and TLR4 in transiently transfected human embryonic kidney 293 cells Bainbridge et al, 2002
  135. TLR2 P. gingivalis stimulated an increase in FOXO1 and FOXO3 mRNA, and of (keratin-1, -10, -14, and involucrin, BID and TRADD and reduced mRNA levels of genes TLR-2 and TLR4) and reduced those associated with barrier function (integrin beta-1, -3 and -6) in gingival epithelial cells Li et al, 2013.
  136. TLR4 toll like receptor 4: upregulated by the Groel protein Huang et al, 2016
  137. TLR9 toll like receptor 9: P. Gingivalis DNA stimulates TLR9-transfected cells Nonnenmacher et al. 2003
  138. TNF cleaved by a P.gingivalis gingipain Mezyk-Kopec et al, 2005
  139. TNFSF11. TNF superfamily member 11 (RANKL): P. gingivalis induces RANKL in bone marrow stromal cells Reddi et al, 2011.
  140. TNFRSF11B tumor necrosis factor receptor superfamily member 11b: Cleaved by P.gingivalis gingipains. Giacaman et al,2009
  141. TRADD TNFRSF1A associated via death domain : P. gingivalis stimulated an increase in FOXO1 and FOXO3 mRNA, and of (keratin-1, -10, -14, and involucrin, BID and TRADD and reduced mRNA levels of genes TLR-2 and TLR4) and reduced those associated with barrier function (integrin beta-1, -3 and -6) in gingival epithelial cells Li et al, 2013.
  142. TRAF6 TNF receptor associated factor 6; suppression inhibits inflammatory response to P. gingivialis in human periodontal ligament cells Tang et al, 2011.
  143. TREM1 triggering receptor expressed on myeloid cells 1: upregulated in peritoneal macrophages by P.Gingivalis Lei et al, 2013
  144. TREM2 triggering receptor expressed on myeloid cells 2 : P. gingivalis induced significant upregulation of TLR2, TLR6, CD14, C5aR, TREM1 and downregulation of TLR5, CXCR4, TREM2 in mouse macrophages Liang et al, 2009
  145. TYROBP TYRO protein tyrosine kinase binding protein: (DAP12) P. gingivalis can positively regulate the expression of the TREM-1/DAP12 pathway in monocytic cells. Bostanci et al, 2011
  146. VAMP2 vesicle associated membrane protein 2: P. gingivalis in early endosomes recruits VAMP2 and Rab4A Takeuchi et al, 2016
  147. VIM vimentin: citrullinated by P.Gingivalis peptidylarginine deiminase Abdullah et al, 2013
  148. WNT5A Wnt family member 5A : P. gingivalis LPS induced Wnt5a mRNA in the human monocytic cell line THP-1 Nanbara et al, 2012
  149. ZEB1 zinc finger E-box binding homeobox 1: infection of gingival epithelial cells with P.gingivalis induces expression and nuclear localization of ZEB1 Sztukowska et al, 2016

P. Gingivalis Gingipain R2 RgPb substrates: C5 CDH5 F10 F2RL3 ICAM1 ITGB1 SLPI TF TNF PMAP-CUTDB Proteolytic event database


P. Gingivalis Gingipain R2 RgPa substrates APOB C3 CD14 CD27 CD99 CDH2 CDH5 CST3 ELN F2RL1 F10 F9 ICAM1 IFNG IL12A IL12B IL6 IL8 ITGB1 PECAM1 SLPI TF TNF PMAP-CUTDB Proteolytic event database

Porphyromonas gingivalis induces the Epstein-Barr virus lytic switch transactivator BZLF1 ZEBRA by histone modification Imai et al, 2012 also reactivates HIV-1 Imai et al, 2009

Cell surface receptors and proteins targeted by gingipains Reviewed in Guo et al, 2000.

C5AR1 CD2 CD4 CD8 CD14 CD31 CD27 CD40L CD70 CD99 ICAM1 IL1B IL4 IL6 IL6R IL12A IL12B PECAM1 THBD TNF

Bulk experiments

Identification of proteins differentially expressed in human monocytes exposed to Porphyromonas gingivalis and its purified components by high-throughput immunoblotting.Zhou and Amar, 2006

Regulated proteins modified by live P.gingivalis or P.gingivalis LPS or fimbrillin. ANXA4 AURKC BCCIP BCL2 BDKRB2 BECN1 BRCA2 CALR CAPZA2 CAV1 CDC2 CDC42 CDKN1A CENTA1 CENTB2 CLTC CUL2 DCAMKL1 ENAH GGA2 GRIM19 HSF4 IFIT4 ILF3 ITGAV KATNB1 KIF3A LMNA MADS MAP2K4 MAP3K8 MAPK3 MEF2D PPP3CA PRKR PTPN1 RAB RAB27A RABGEF1 RAP2A RBBP4 SKP1A SORT1 SQSTM1 SRF STAT1 STAT3 STAT6 TDE1 TNFSF6 TUBA1 UBCH7 UBE2L3

Identification of signaling pathways in macrophage exposed to Porphyromonas gingivalis or to its purified cell wall components.Zhou and Amar, 2007 ABCA1 ABCC11 ABL2 ACOT6 ACSL1 ACSL4 ACVR2A ADAM17 ADAM20 ADAM22 ADM AFF4 AKAP1 AKAP12 AKNAD1 ANKHD1 ANKLE2 ARHGAP31 ARL4D ARMC5 ATP1B1 ATP2B1 ATP2B2 ATXN1 B4GALT1 B4GALT5 BAMBI BASP1 BCL11A BFSP1 BHLHB9 BPIFA3 BTBD19 BTBD9 BTG2 C11orf96 C12orf66 C16orf79 C17orf47 C19orf50 C1orf86 C22orf15 C22orf45 C5orf47 C6orf145 C7orf63 C8orf42 CA13 CA8 CADPS CALY CCDC108 CCDC65 CCL20 CCL23 CCL4 CCRL2 CD24 CD44 CD55 CD80 CD83 CDH15 CDON CEP350 CFLAR CFTR CHCHD5 CHI3L1 CLCF1 CLEC4E CNKSR3 COBL COL11A1 COL12A1 COL4A1 CPEB4 CSF3 CSPP1 CTF1 CXCL1 CXCL10 CXCL2 CXCL3 CYB5D1 CYP2C9 CYP7A1 DBC1 DCAF12L1 DCAF8 DCAKD DDR2 DDX42 DENND5A DLGAP3 DMRTA1 DMRTC2 DMXL2 DNAJB5 DNHD1 DOT1L DPP7 DPYSL3 DRAM1 DTX2 DUSP1 DUSP2 DUSP5 DYNC1H1 DYNC1I1 DYRK3 DZANK1-AS1 EDN1 EDNRA EGR4 EHD1 EIF2C2 EIF4E ELOVL7 EMID2 EPB41 EREG ESCO2 EVI5L EVX1 EXOSC1 EYA4 F3 FAM71F2 FCGR1A FCRL5 FERMT2 FFAR2 FGFR1OP2 FLJ13224 FLJ35934 FLJ45513 FLJ90680 FNDC3B FOSL1 FOXP2 FRY FSCN1 FTX FUBP3 FUT4 G0S2 GABRA1 GEMIN7 GFER GH2 GIPR GNAS GPC1 GPC3 GPM6A GPR180 GPR84 GRAMD1A GRIN2A GSK3B HAB1 HAPLN1 HDAC4 HECTD2 HELQ HERC1 HES4 HEY1 HGF HIPK2 HMGB3P22 HOXA6 HOXB1 HPS4 HSPA1A HSPB7 HYMAI ICA1L ICAM1 ICAM4 ICOSLG ID4 IER3 IGHV5-78 IL10 IL12B IL17RE IL18 IL1A IL1B IL1R1 IL20RA IL23A IL6 IQCG IQCH IQSEC3 IRAK2 IRF8 IRG1 IST1 ITGB8 ITPRIP IYD JAG1 JRK KANK1 KBTBD10 KCNAB1 KCNE4 KDM6B KIAA2018 KIF1B KIR2DL1 KIR2DL2 KLF5 KLF6 KLHL14 KLHL28 KLHL3 KLHL4 KRT19 KRT36 KRTAP3-3 LAMA3 LCOR LDLR LIF LIFR LIMK2 LIN28B LINC00112 LINC00221 LINC00486 LITAF LMO3 LOC100129069 LOC100130417 LOC100131096 LOC100133660 LOC100134229 LOC100272228 LOC148413 LOC283140 LOC283737 LOC283861 LOC284240 LOC284454 LOC285628 LOC286009 LOC338758 LOC339874 LOC388906 LOC401317 LOC440896 LOC641518 LOC646482 LPHN3 LRCH3 LSS LTBP4 MAB21L1 MACF1 MAFF MAGEA10 MAGEA5 MAK MAP1B MAP2K3 MARCKS MB21D1 MBNL1 MED26 MESDC1 MFSD2A MIER1 MIIP MIR22HG MMP8 MN1 MPP3 MRI1 MSC MTF1 MUM1L1 MYL2 MYOG NAMPT NANOS2 NAP1L4 NBN NCAN NCK2 NCOR2 NDP NDRG1 NECAP2 NEDD4L NEFL NFAT5 NFKB1 NFKB2 NFKBIA NFKBID NINJ1 NIPAL1 NIPAL4 NKX3-1 NLRP14 NME7 NOTCH4 NR4A1 NR4A3 NRL OAF ODF3B OR7C1 OSM OSR2 OTOF OTUD7B P2RX7 PALLD PAX3 PCNXL2 PDE2A PDGFB PDP1 PIM3 PKD1L1 PKP1 PLA2G5 PLAGL2 PLAUR PLK3 PNLIP PNLIPRP1 PNRC1 PPAP2B PPP1R14A PPP1R15A PPP3CC PRKCD PSD3 PTGS2 PTPN1 PTPRF PTX3 PURB PXDN QRICH2 RAB3GAP2 RAB6B RAG2 RAP2C RAPGEF2 RAPH1 RARRES1 RASAL2 RASGEF1B RCAN1 RCN3 REL RELB REM2 RGS16 RIPK2 RND3 RNF144B RNF213 RPS16P5 RPS2P45 RSPO1 S1PR3 SCN1B SDC4 SEC14L1 SELENBP1 SEMA6A SEMA6C SERPINB2 SERPINB8 SERPINE1 SFPQ SGMS2 SGPP2 SHANK1 SHD SLC1A2 SLC22A23 SLC26A9 SLC28A1 SLC28A2 SLC2A11 SLC2A13 SLC2A6 SLC39A14 SLC5A1 SLC6A15 SLCO3A1 SMAD4 SMTN SNN SNORA28 SNTG1 SOD2 SOD3 SPAM1 SPON1 SPP2 SPSB1 SQSTM1 SRC SRGAP1 SRPK2 ST3GAL1 ST7-AS1 STARD8 STAT5A STBD1 STON2 SVIL SYCE1 SYDE1 SYT9 TADA3 TBC1D9 TCEB3B TCF7L2 TCTE3 TFAP2B TGIF2LY TLR2 TLR7 TMCO2 TMED10 TMEM67 TMEM88 TMPRSS6 TNF TNFAIP2 TNFAIP3 TNFRSF9 TNFSF15 TNFSF9 TNIP1 TNIP2 TNP1 TNS1 TOB2 TP53INP2 TPD52 TPRA1 TRAF1 TRIM36 TRIP10 TSLP TTBK1 TTC9 UPK2 VAPB VEGFA VIM VPS35 WDR87 WISP2 WNK4 WNT5A WTAP WWC1 XIRP1 XPNPEP3 XRCC5 YRDC ZBTB43 ZC3H12A ZC3H12C ZC3H7B ZCWPW1 ZEB2 ZG16 ZNF131 ZNF503 ZNF876P

 

Rapid Myeloid Cell Transcriptional and Proteomic Responses to Periodontopathogenic Porphyromonas gingivalis Nares et al, 2009

Early transcriptional response to P. gingivalis LPS

Genes affected in monocytes, macrophages or dendritic cells ABL2 ACSL1 ACVR2A ADM ADORA2A ANKRD15 ANKRD28 ARL5B ARRDC3 ATF3 AXUD1 B4GALT1 BCL11A BCL2A1 BHLHB2 BIRC3 BRE BTG1 BTG2 BTG3 C11orf17 C15orf48 C21orf7 C21orf71 C22orf37 C2orf55 C7orf40 CCL2 CCL20 CCL23 CCL3 CCL4 CCL5 CCL8 CCR2 CCRL2 CCRN4L CD40 CD44 CD69 CD80 CD83 CDC20B CEPT1 CFLAR CLCF1 CSF2 CST6 CXCL1 CXCL10 CXCL2 CXCL3 CYB5D1 DAB2 DDIT4 DKFZP686M0199 DMXL2 DNAJB4 DOCK4 DRAM DUSP1 DUSP2 DUSP5 DUSP6 DYRK3 EBI2 EDN1 EDNRB EFNA1 EGR1 EGR3 EHD1 EIF4E EREG ETS2 ETV3 F3 FCAR FFAR2 FOS FOSB FOSL1 FSCN1 G0S2 GADD45A GADD45B GBP1 GBP2 GBP3 GCH1 GEM GJB2 GPR109B GPR132 GPR84 GRAMD1A HEXA HEY1 HHEX HOXA5 ICAM1 ID1 ID2 ID3 IER2 IER3 IFIT2 IFNB1 IFNGR1 IKZF1 IL10 IL12B IL18 IL1A IL1B IL1RN IL23A IL6 IL7R IL8 INHBA INSIG1 IRAK2 IRF1 IRG1 ISG20 ITPKB JAG1 JMJD3 JUN JUNB KCNJ2 KIF1B KLF6 KLF9 KMO KRT23 LCP2 LIPA LOC285758 LOC338758 LOC387763 LOC399900 LOC440896 LOC440934 LOC641912 LOC641912 LOC646561 LOC647190 LOC651466 LOC731424 LOC732415 LRRC32 LRRC50 MAF MAFF MAP2K3 MAP3K8 MBNL1 MFSD2 MGC11082 MGC5618 MIRN155 MMP10 MMP19 MOBKL2C MS4A6A MSC MT1M MXD1 MYC MYO1G NFE2L2 NFIL3 NFKB2 NFKBIA NFKBIZ NINJ1 NLRP3 NPL NR4A1 NR4A2 NR4A3 NRP2 OASL OLR1 OSM OSR2 OTUD1 PBEF1 PDE4B PDE6H PDGFB PDSS1 PELI1 PFKFB3 PHLDA1 PHLDA2 PIM3 PLA1A PLAU PLAUR PLEK PLEKHF2 PLK2 PLK3 PMAIP1 PNRC1 PPP1R15A PPP1R15B PRDM1 PTGER4 PTGS2 PTX3 RALGDS RAPGEF2 RASGEF1B RBBP6 REL RGS1 RHOF RILPL2 RIN2 RIPK2 RNF144B RNF19B RPUSD2 RRAD S100A10 SAMSN1 SDC4 SERPINB2 SERPINB9 SERPINE1 SLAMF1 SLC11A2 SLC1A3 SLC2A6 SLC39A8 SNAI1 SOCS3 SOCS6 SOD2 SRGN STX11 TA-NFKBH THBD THBS1 TIFA TJP2 TLR2 TMEM88 TncRNA TNF TNFAIP2 TNFAIP3 TNFAIP6 TNFAIP8 TNFSF9 TNIP1 TNIP2 TNIP3 TRAF1 TSLP TXNIP UBR2 UPB1 UPP1 VIM WDR1 WDR78 WTAP YRDC ZBTB10 ZC3H12A ZC3H12C ZFP36 ZNF224 ZNF627 ZNF697

The periodontal pathogen Porphyromonas gingivalis changes the gene expression in vascular smooth muscle cells involving the TGFbeta/Notch signalling pathway and increased cell proliferation. Zhang et al, 2013

Upregulated ABCA1 ABCA4 ABI3BP ACSL3 ACTA2 ACTBL2 ACTG2 ACTN1 ACTN3 ADA ADAM19 ADAMTS10 ADAMTS14 ADAMTS4 ADAMTS5 ADC ADORA2A ADORA2B AGT AKAP13 AKR1B10 ALDH1A1 ALPK2 AMOTL1 ANGPT2 ANK1 ANKFY1 APC2 APOC1 APOE APOL6 ARHGAP24 ARHGAP26 ARHGAP31 ARHGAP44 ARHGAP6 ARHGEF17 ARHGEF9 ARID5A ARL4C ARSI ART4 ASB2 ATF3 ATHL1 ATP10A ATP6AP1L ATXN1 B3GNT2 BAALC BAHCC1 BEX1 BGN BHLHE40 BMF BMP1 BPGM BTG1 BVES C15orf39 C1QB C1QTNF5 C2orf27A C5AR1 C5orf46 C6orf165 C7orf69 CA4 CALD1 CALHM2 CAMK1G CAST CCDC102B CCDC3 CCDC68 CCDC81 CCL1 CCL11 CCNYL1 CDKN2B CDX1 CELA2A CELA2B CENPN CGNL1 CH25H CHD7 CHST11 CHST2 CHST3 CHST6 CHSY1 CHSY3 CISH CLDN14 CLEC18B CLIP2 CNGA1 CNN1 CNNM2 COL14A1 COL15A1 COL18A1 COL27A1 COL4A1 COL4A2 COL5A3 COL6A3 CRISPLD2 CSF1R CSRNP1 CTGF CTHRC1 CTSC CX3CL1 CXXC5 CYGB CYTH3 DAAM2 DAB2IP DAND5 DBNDD2 DCLK2 DEPTOR DPT DSP DZIP1L EBF1 EDNRA EFNA1 EFNB1 ELN EMILIN2 ENC1 ENPP2 EPHB2 ERRFI1 ETS1 ETV6 EVL F2RL1 FABP5 FAM101B FAM182B FAM27E1 FAM46B FAM55B FAM59A FGF1 FGFR3 FHL3 FIBIN FMNL3 FMOD FNIP2 FRMD8 FSTL3 FURIN FZD4 G0S2 GADD45A GADD45B GBP1 GEN1 GGT5 GHR GLIPR2 GNG2 GPM6B GPR124 GPR126 GPR56 GPRC5C GUCY1A2 GUCY1A3 GUCY1B3 H19 HAS2 HBEGF HECW2 HES1 HES4 HES5 HEY1 HEY2 HEYL HIC1 HIGD1B HILS1 HSPA2 HTRA3 ID1 ID3 ID4 IER3 IFNGR1 IGF2 IL17B IL18R1 IL18RAP IL1RL1 IL21R IL34 INHBA ISG20 ISYNA1 ITGA1 ITGA11 ITGB3 JAG1 JPH2 JUNB KBTBD11 KCNE4 KCNIP3 KCNN3 KIAA1755 KLF10 KLF9 KRT18 KRT18P55 KRT7 KSR1 LAMB3 LGMN LGR4 LIMD2 LIMK2 LIMS1 LINC00312 LINC00340 LIPG LMCD1 LMO2 LOC100287221 LOC100507254 LOC284561 LOC388242 LOC572558 LOC643733 LOC84856 LOXL3 LPPR4 LRRC15 LRRC32 LSP1 LZTS1 MAFK MAN1C1 MAP2 MBP MCAM MEG3 MEGF6 MEX3B MICALL2 MIR143HG MKL2 MLPH MLXIP MPRIP MRAP2 MYH10 MYH9 MYLK2 NAV1 NES NEURL1B NGFR NHS NKAIN4 NOD1 NOTCH1 NOTCH3 NOTCH4 NOX4 NPAS2 NPR3 NPTXR NREP NT5DC2 OLFM2 OLFML2A OLFML2B PAG1 PCDHGC3 PCSK1 PDE3A PDGFA PDGFRB PDLIM3 PF4 PGM2L1 PHLDB1 PITPNC1 PKNOX2 PLCE1 PLD1 PLEKHG2 PLEKHG3 PLXDC1 PLXDC2 PLXND1 PMEPA1 POM121L8P POM121L9P POTEKP PPAP2A PPAPDC1A PPARGC1B PPP1R14C PPP1R3B PREB PRKAB2 PRKG1 PRR5 PRR5L PRSS35 PTH1R PTK2 RADIL RASD1 RGS4 RHBDF2 RHOJ RIN3 RIPK4 RNF121 RNF122 RNF144A RNF152 RPSA S100A3 S1PR5 SAMD5 SASH1 SAT1 SCG2 SCML1 SDC2 SEMA3G SEMA4C SEMA5B SEPT11 SEPT4 SEPT5 SEPT7P2 SERINC5 SERPINA3 SGCD SGPL1 SH3PXD2A SHROOM3 SLC15A4 SLC16A12 SLC17A9 SLC1A4 SLC29A1 SLC30A3 SLC9A3R1 SLC9A3R2 SLCO2A1 SMAD3 SMC6 SNAI1 SNAI2 SORBS2 SOX4 SPARCL1 SPATS2L SPHK1 SPOCD1 SPON2 SPP1 ST3GAL2 STC2 STK17A STON1 STON1-GTF2A1L STRA6 SULF2 SUSD2 TACC2 TAGLN2 TBC1D2B TBX2 TCP11L2 TDO2 TES TGFB1 TGFB3 TGFBI TGFBR1 TGM2 THY1 TMC4 TMEM100 TMEM119 TMEM133 TMEM204 TMEM217 TMEM45A TNFAIP6 TNFSF4 TNNT3 TNS1 TPM1 TPST2 TPX2 TRAF5 TRIB1 TRIM5 TSPAN11 TSPAN9 TTYH2 TUFT1 UACA UBASH3B UNC5B UPB1 UPP1 VSTM4 WISP1 WNT2B WNT4 WNT5A WWC1 WWTR1 XAF1 XYLT1 ZCCHC5 ZEB2 ZFP1 ZMIZ2 ZNF423 ZNF469 ZNF697 ZNF93

 

Downregulated ABAT ABCA3 ABCA6 ABCA8 ABCC2 ABCC3 ABHD8 ABLIM3 ACYP1 ADAMTS1 ADAMTS6 ADAMTSL1 ADAMTSL4 ADD3 ADH1A ADH1C ADHFE1 ADM ADRA1B AGPAT9 AHNAK2 AKAP2 AKR1C1 ALDH3A2 ALDH6A1 AMOT AMPD3 ANGPT1 ANGPTL4 ANKRD13A ANKRD35 ANTXR2 ANXA10 ANXA3 AOX1 AP1S3 AQP5 ARHGAP18 ARHGEF3 ARID5B ARNT2 ARNTL2 ARRDC3 ARSE ASPM ATAD2 ATP6V0E2 ATP8B1 AVPI1 BATF2 BCHE BDKRB1 BDKRB2 BDNF BIRC3 BMP2 BNC2 BTN2A2 C10orf54 C11orf87 C14orf132 C1orf167 C1orf213 C1orf228 C1RL C20orf132 C22orf15 C3orf23 C4orf49 C5 C5orf4 C7orf46 C7orf58 C9orf167 CA12 CACNG6 CAND2 CARD16 CASP1 CBR3 CBX7 CCBE1 CCDC125 CCDC85B CCL7 CCNO CCRL1 CD200 CD302 CDCA2 CDCP1 CDH18 CDNF CEBPD CELF2 CEP70 CFL1P1 CHEK1 CHEK2 CIT CITED2 CITED4 CLDN1 CLDN11 CLEC2B CLGN CLIC3 CLMP CNIH3 CNTN3 COL13A1 COL8A2 COLEC12 CPA4 CRISPLD1 CROT CTSK CTTNBP2 CXCR7 CYB5A CYP2S1 DBP DDIT4L DGAT2 DGKE DHRS1 DHRS13 DHRS3 DIO2 DIRAS3 DISC1 DKK1 DOCK11 DOCK3 DOK5 DPF3 DPP4 DPYD DPYSL3 DRAM1 DSEL DTNA DTWD1 DTWD2 DYNC2H1 EDNRB EGR1 EGR3 EIF5A2 ENOX1 EPHA2 EPHA5 EPHX2 EPSTI1 ERCC6 EREG ESM1 ETS2 ETV1 EVI2A EXOC6 FAIM2 FAM101A FAM102B FAM111A FAM20A FAM211A FAM40B FAM65C FBXO27 FGF16 FGF5 FGF7 FHL2 FIG4 FLJ31356 FLOT2 FLRT3 FOS FRAS1 FRMD5 FST FYCO1 FZD1 FZD7 GALM GAS1 GATA2 GBP2 GCHFR GCNT1 GDF5 GFOD1 GKAP1 GLRB GLRX GMPR GNG11 GPER GPR1 GPR39 GPRC5A GPRC5B GREM2 GSG1 GULP1 GYG2 HHIP HJURP HMGA1 HMGA2 HOXA5 HOXA7 HS6ST3 HSBP1L1 HSD17B6 HSD17B8 HSD3B7 HSPA4L HTR2B ID2 IFIT1 IFNE IGFBP5 IKZF2 IL17RD IL1A IL7 IL8 INPP5D IRAK1BP1 ITGA2 ITGA6 ITGB8 JMJD5 KANK1 KBTBD3 KCNAB1 KCNJ2 KCNJ2-AS1 KCNJ8 KCNK2 KCNMA1 KCTD8 KGFLP1 KIAA1199 KIAA1324L KIF18A KLF15 KLF4 KLHDC9 KRR1 KRT19 KRTAP1-5 LACC1 LDB2 LGALS8-AS1 LINC00238 LIPC LIPH LMO3 LOC100126784 LOC100128822 LOC100144602 LOC100192378 LOC100287482 LOC257396 LOC283481 LOC400550 LOC400684 LOC643650 LOC645431 LOC646976 LOC730091 LOC730101 LOC81691 LONRF2 LOXL4 LPAR1 LRIG3 LRRC8C LRRC8D LRRK2 LRRN3 MAL2 MALL MAN1A1 MANSC1 MAP3K8 MARCH3 MASP1 MAZ MC4R MCOLN2 MEIS1 MESP1 MET METTL7A MITF MT1B MT1E MT1F MT1G MT1H MT1L MT1M MT1P2 MT1X MT2A MTSS1 MYB MYBL1 MYO15A MYOZ2 NAMPT NBLA00301 NCEH1 NCKAP5 NET1 NEXN-AS1 NFE2L3 NFKBIZ NGEF NIPAL3 NLGN1 NME5 NMT2 NMU NOV NPTX1 NR3C1 NT5DC1 NT5E OBFC2A OCIAD2 OGFRL1 OSBPL8 OXTR P2RX6P PARD3 PARD6A PC PCDH18 PCSK6 PDE1C PDE4B PDGFD PDGFRA PDZRN3 PER3 PGBD3 PGPEP1 PHF15 PHLDA1 PHOSPHO2 PIK3R1 PIM2 PION PIP PKIA PKP3 PLA2G16 PLAT PLAU PLD6 PLEKHA6 PLEKHG4 PLSCR4 PM20D2 PML PNMAL1 PODXL PPIP5K1 PPL PPP2R2D PPP4R4 PRIM2 PRKCA PRNP PRR15 PRR16 PRRT2 PRRT3 PRSS2 PRSS3 PRUNE2 PSEN2 PTGER4 PTGFR PTGIS PTX3 PYROXD2 RAC2 RALGPS2 RAMP1 RASSF2 RASSF5 RASSF7 RBM47 RDH10 RDH5 RECK RGCC RGN RGNEF RGS17 RGS2 RGS7BP RHOU RILP RIMBP3 RMI2 RNF112 RTKN2 S1PR1 SALL2 SAMD3 SCARA3 SCN9A SDC4 SDPR SEMA3A SEMA3C SEMA3D SERAC1 SERPINB2 SERTAD2 SFR1 SFRP1 SH3BGRL2 SH3D19 SHC4 SKA1 SLC14A1 SLC16A4 SLC16A7 SLC16A9 SLC1A1 SLC1A2 SLC20A1 SLC23A2 SLC25A23 SLC25A40 SLC2A1 SLC35F3 SLC39A8 SLC40A1 SLC43A3 SLC48A1 SLC6A6 SLC7A14 SLC7A2 SLC7A4 SLC7A8 SLC9A9 SLITRK4 SNCA SNTB1 SOCS3 SOD2 SOST SOX9 SPC24 SPRY1 SPTLC3 SSR4P1 SSTR1 ST3GAL6 STAR STAU2 STC1 STEAP1 STEAP2 STEAP3 STMN1 SUCNR1 SULT1B1 SULT1E1 SUMF2 SVEP1 SYBU SYNPO2 TCEA3 TGFBR2 TGFBR3 THBD THSD4 TIMP3 TIPARP TLE4 TM4SF1 TM7SF2 TMEFF2 TMEM106C TMEM130 TMEM132B TMEM155 TMEM158 TMEM192 TMEM200A TMEM25 TMEM38A TMTC1 TMTC2 TMTC4 TMX4 TNFAIP8 TNFRSF11B TNFRSF21 TNFRSF8 TNFSF13B TNFSF14 TNFSF9 TNIK TNNC2 TNXB TP53TG3 TPK1 TRIM2 TRIOBP TSC22D1-AS1 TSHZ2 TSLP TSPAN8 TWSG1 TXNRD1 UBXN2B USP53 VASN VCAM1 VEGFC VIT VWA5A VWCE WBSCR27 WDR66 WHSC1 WISP2 YPEL4 ZDHHC23 ZNF323 ZNF365 ZNF395 ZSCAN16

Transcriptional profiling of human smooth muscle cells infected with gingipain and fimbriae mutants of Porphyromonas gingivalis Zhang et al, 2016

Several strains were used in this study: The wild type P. gingivalis strains, ATCC33277 (Table S1), W50 (Table S2), and 381 (Table S3) showed more power to regulate the gene expression than E8 (Table S4), K1A (Table S5), DPG3 (Table S6), and KRX178 (Table S7) in AoSMCs.

wild type P. gingivalis strain, ATCC33277

Upregulated ABCA1 ABCA4 ABI3BP ACSL3 ACTA2 ACTBL2 ACTG2 ACTN1 ACTN3 ADA ADAM19 ADAMTS10 ADAMTS14 ADAMTS4 ADAMTS5 ADORA2A ADORA2B AGT AKAP13 AKR1B10 ALDH1A1 ALPK2 AMOTL1 ANGPT2 ANK1 ANKFY1 APC2 APOC1 APOE APOL6 ARHGAP24 ARHGAP26 ARHGAP31 ARHGAP44 ARHGAP6 ARHGEF17 ARHGEF9 ARID5A ARL4C ARSI ART4 ASB2 ATF3 ATHL1 ATP10A ATP6AP1L ATXN1 AZIN2 B3GNT2 BAALC BAHCC1 BEX1 BGN BHLHE40 BMF BMP1 BPGM BTG1 BVES C15orf39 C1QB C1QTNF5 C2orf27A C5AR1 C5orf46 C6orf165 C7orf69 CA4 CALD1 CALHM2 CAMK1G CASC15 CAST CCDC102B CCDC3 CCDC68 CCDC81 CCL1 CCL11 CCNYL1 CDKN2B CDX1 CELA2A CELA2B CENPN CGNL1 CH25H CHD7 CHST11 CHST2 CHST3 CHST6 CHSY1 CHSY3 CISH CLDN14 CLEC18B CLIP2 CNGA1 CNN1 CNNM2 COL14A1 COL15A1 COL18A1 COL27A1 COL4A1 COL4A2 COL5A3 COL6A3 CRISPLD2 CSF1R CSRNP1 CTGF CTHRC1 CTSC CX3CL1 CXXC5 CYGB CYTH3 DAAM2 DAB2IP DAND5 DBNDD2 DCLK2 DEPTOR DPT DSP DUXAP10 DZIP1L EBF1 EDNRA EFNA1 EFNB1 ELN EMILIN2 ENC1 ENPP2 EPHB2 ERRFI1 ETS1 ETV6 EVL F2RL1 FABP5 FAM101B FAM182B FAM27E2 FAM46B FGF1 FGFR3 FHL3 FIBIN FMNL3 FMOD FNIP2 FRMD8 FSTL3 FURIN FZD4 G0S2 GADD45A GADD45B GAREM GBP1 GEN1 GGT5 GHR GLIPR2 GNG2 GPM6B GPR124 GPR126 GPR56 GPRC5C GUCY1A2 GUCY1A3 GUCY1B3 H19 HAS2 HBEGF HECW2 HES1 HES4 HES5 HEY1 HEY2 HEYL HIC1 HIGD1B HILS1 HSPA2 HTRA3 ID1 ID3 ID4 IER3 IFNGR1 IGF2 IL17B IL18R1 IL18RAP IL1RL1 IL21R IL34 INHBA ISG20 ISYNA1 ITGA1 ITGA11 ITGB3 JAG1 JPH2 JUNB KBTBD11 KCNE4 KCNIP3 KCNN3 KIAA1755 KLF10 KLF9 KRT18 KRT18P55 KRT7 KSR1 LAMB3 LGMN LGR4 LIMD2 LIMK2 LIMS1 LINC00312 LINC00839 LINC01013 LIPG LMCD1 LMO2 LOC100287221 LOC284561 LOC388242 LOC643733 LOXL3 LPPR4 LRRC15 LRRC32 LSP1 LZTS1 MAFK MAN1C1 MAP2 MBP MCAM MEGF6 MEX3B MICALL2 MIR143HG MKL2 MLPH MLXIP MPRIP MRAP2 MYH10 MYH9 MYLK2 NAV1 NES NEURL1B NGFR NHS NKAIN4 NOD1 NOTCH1 NOTCH3 NOTCH4 NOX4 NPAS2 NPR3 NPTXR NREP NT5DC2 NXPE2 OLFM2 OLFML2A OLFML2B PAG1 PCDHGC3 PCSK1 PDE3A PDGFA PDGFRB PDLIM3 PF4 PGM2L1 PGM5P4-AS1 PHLDB1 PITPNC1 PKNOX2 PLCE1 PLD1 PLEKHG2 PLEKHG3 PLXDC1 PLXDC2 PLXND1 PMEPA1 POM121L8P POM121L9P POTEKP PPAP2A PPAPDC1A PPARGC1B PPP1R14C PPP1R3B PREB PRKAB2 PRKG1 PRR5 PRR5L PRSS35 PTH1R PTK2 RADIL RASD1 RGS4 RHBDF2 RHOJ RIN3 RIPK4 RNF121 RNF122 RNF144A RNF152 RPSA S100A3 S1PR5 SAMD5 SASH1 SAT1 SCG2 SCML1 SDC2 SEMA3G SEMA4C SEMA5B SEPT11 SEPT4 SEPT5 SEPT7P2 SERINC5 SERPINA3 SGCD SGPL1 SH3PXD2A SHROOM3 SLC15A4 SLC16A12 SLC17A9 SLC1A4 SLC29A1 SLC30A3 SLC9A3R1 SLC9A3R2 SLCO2A1 SMAD3 SMC6 SNAI1 SNAI2 SORBS2 SOX4 SPARCL1 SPATS2L SPHK1 SPOCD1 SPON2 SPP1 ST3GAL2 STC2 STK17A STON1 STON1-GTF2A1L STRA6 SULF2 SUSD2 TACC2 TAGLN2 TBC1D2B TBX2 TCP11L2 TDO2 TES TGFB1 TGFB3 TGFBI TGFBR1 TGM2 THY1 TMC4 TMEM100 TMEM119 TMEM133 TMEM204 TMEM217 TMEM45A TNFAIP6 TNFSF4 TNNT3 TNS1 TPM1 TPST2 TPX2 TRAF5 TRIB1 TRIM5 TSPAN11 TSPAN9 TTYH2 TUFT1 UACA UBASH3B UNC5B UPB1 UPP1 VSTM4 WISP1 WNT2B WNT4 WNT5A WWC1 WWTR1 XAF1 XYLT1 ZCCHC5 ZEB2 ZFP1 ZMIZ2 ZNF423 ZNF469 ZNF697 ZNF93

Downregulated A1BG ABAT ABCA3 ABCA6 ABCA8 ABCA9 ABCC2 ABCC3 ABCC4 ABHD8 ABLIM3 ACCS ACKR3 ACKR4 ACO1 ACTB ACTC1 ACTG1 ACTG1P4 ACTR3 ACVR2A ACYP1 ADAMTS1 ADAMTS6 ADAMTSL1 ADAMTSL4 ADCK2 ADCY9 ADD3 ADH1A ADH1C ADHFE1 ADM ADRA1B AGBL5 AGPAT5 AGPAT9 AHNAK2 AK5 AKAP12 AKAP2 AKAP7 AKR1C1 ALDH3A2 ALDH6A1 ALDOC ALMS1 AMD1 AMOT AMPD3 ANGPT1 ANGPTL4 ANKRD13A ANKRD18A ANKRD35 ANKRD9 ANO6 ANP32D ANTXR2 ANXA10 ANXA11 ANXA2 ANXA2R ANXA3 ANXA4 ANXA8L1 AOX1 AP1S3 AP3M2 AP4S1 APOL2 APOL4 APOLD1 APOM AQP1 AQP3 AQP5 ARFGAP1 ARG2 ARHGAP12 ARHGAP17 ARHGAP18 ARHGEF28 ARHGEF3 ARHGEF7 ARID5B ARIH2OS ARL15 ARNT2 ARNTL2 ARRDC3 ARSE ASPHD2 ASPM ATAD2 ATP6V0B ATP6V0E2 ATP6V0E2-AS1 ATP8B1 ATP9A AUH AVPI1 B3GALT4 B4GALT3 B9D1 BATF2 BBS10 BCAR1 BCHE BCL2L14 BDH1 BDH2 BDKRB1 BDKRB2 BDNF BEX2 BIRC3 BMP2 BMP2K BMPER BNC2 BOLA2 BTN2A2 C10orf10 C10orf54 C11orf54 C11orf87 C12orf75 C12orf76 C14orf132 C15orf59 C16orf45 C17orf75 C19orf57 C1GALT1C1 C1orf167 C1orf198 C1orf21 C1orf213 C1orf228 C1orf56 C1QTNF6 C1RL C22orf15 C22orf23 C2CD2 C2CD5 C3 C3orf18 C5 C5orf55 C6orf1 C8orf34 C8orf48 C9orf47 C9orf50 CA12 CAAP1 CABLES1 CACNG6 CACYBP CALM1 CAMK2D CAND2 CAPRIN1 CARD16 CARD17 CASP1 CASP10 CASP9 CAT CBR3 CBX7 CC2D2A CCBE1 CCDC115 CCDC125 CCDC71L CCDC80 CCDC85B CCDC85C CCDC9 CCL7 CCND1 CCND3 CCNL1 CCNO CCRN4L CD200 CD302 CDC14B CDC23 CDC42SE1 CDC7 CDCA2 CDCP1 CDH10 CDH18 CDH2 CDK20 CDKL5 CDKN1B CDKN2C CDKN3 CDNF CDR2L CDYL CEBPB CEBPD CEBPE CELF2 CEMIP CEP70 CETN3 CFD CFL1P1 CHADL CHEK1 CHEK2 CHGA CHN1 CHRD CHST7 CIT CITED2 CITED4 CLDN1 CLDN11 CLEC14A CLEC2B CLGN CLIC3 CLIP4 CLMP CLN3 CMBL CNIH3 CNTN3 COBLL1 COL13A1 COL5A1 COL5A2 COL8A2 COLEC11 COLEC12 COLGALT1 COMMD8 CPA4 CPED1 CREB3L1 CREB3L4 CREB5 CREBL2 CRISPLD1 CRLF3 CROT CSGALNACT1 CSTF2T CTNNAL1 CTSK CTSL CTTNBP2 CXCL12 CXCL8 CYB5A CYBRD1 CYFIP2 CYHR1 CYP2S1 CYP2U1 DAAM1 DACT3 DAPK3 DBNDD1 DBP DCBLD2 DCN DCUN1D3 DDIT4L DDR1 DDX52 DENND2D DENND3 DEPDC7 DFNA5 DGAT2 DGKE DHFR DHFRL1 DHRS1 DHRS13 DHRS3 DHRS7 DICER1-AS1 DIO2 DIRAS3 DISC1 DKK1 DLEU1 DLG1 DNAH2 DNMBP DOCK11 DOCK3 DOCK4 DOK1 DOK4 DOK5 DPF3 DPP4 DPY19L1 DPYD DPYSL2 DPYSL3 DRAM1 DSEL DST DSTN DTNA DTWD1 DTWD2 DUSP19 DYNC2H1 DYRK2 E2F7 EBF3 ECH1 ECHDC2 EDNRB EFHC1 EGR1 EGR3 EHD3 EIF5A2 ELF4 ELL2 EML1 ENOSF1 ENOX1 EPHA2 EPHA5 EPHA5-AS1 EPHB6 EPHX2 EPOR EPSTI1 ERCC6 EREG ERLIN2 ESM1 ETS2 ETV1 EVI2A EXOC6 EXOC6B EXT1 FAIM2 FAM101A FAM102B FAM111A FAM118A FAM134B FAM151A FAM162A FAM167B FAM198B FAM20A FAM221A FAM27C FAM65C FARP1 FAT1 FAXDC2 FBLIM1 FBXO27 FEM1B FENDRR FGF14-AS2 FGF16 FGF2 FGF5 FGF7 FGFR1 FHL2 FIG4 FLJ26850 FLJ31356 FLOT2 FLRT2 FLRT3 FN1 FNDC3B FOS FOSL1 FOXJ1 FOXK1 FOXRED2 FRAS1 FRMD5 FST FUCA1 FUK FUT8 FUT8-AS1 FYCO1 FZD1 FZD7 GABRE GALM GALNT5 GAMT GAS1 GATA2 GATA2-AS1 GBA2 GBP2 GBP3 GCH1 GCHFR GCNT1 GDE1 GDF5 GFOD1 GJA1 GKAP1 GLCCI1 GLRB GLRX GM2A GMDS-AS1 GMPR GNAZ GNB4 GNG11 GNPDA1 GNPTAB GOLPH3L GOLT1B GPCPD1 GPER1 GPNMB GPR1 GPR137B GPR180 GPR39 GPRASP1 GPRC5A GPRC5B GPSM2 GRAMD3 GREM2 GSAP GSG1 GSTM5 GULP1 GYG2 H6PD HADH HAGH HAND2 HAND2-AS1 HEXIM2 HFE HGF HHAT HHIP HIBCH HIP1R HIST1H1C HJURP HMGA1 HMGA2 HMGB3 HMGN3 HOMER1 HOXA10 HOXA3 HOXA5 HOXA7 HPCA HPCAL1 HPS3 HS2ST1 HS3ST3A1 HS6ST3 HSBP1L1 HSD17B6 HSD17B7 HSD17B8 HSD3B7 HSPA4L HTR2B HTR7 HYKK ID2 IDH1 IDH2 IDNK IFFO1 IFI44 IFI44L IFIH1 IFIT1 IFNE IGFBP5 IKBIP IKBKB IKZF2 IL15RA IL17D IL17RC IL17RD IL18BP IL1A IL33 IL7 INPP5D INTS6-AS1 INTU IQCK IRAK1BP1 IRF1 ISOC1 ITGA2 ITGA6 ITGB5 ITGB8 ITPKC ITPRIPL2 IVNS1ABP JADE2 JADE3 JMJD6 JMJD7 JUN KANK1 KAT2B KAZALD1 KAZN KBTBD3 KCNAB1 KCNG1 KCNJ2 KCNJ2-AS1 KCNJ8 KCNK2 KCNK6 KCNMA1 KCNN4 KCTD10 KCTD12 KCTD15 KCTD8 KDELR2 KDM8 KGFLP1 KHDC1 KIAA0101 KIAA0247 KIAA0930 KIAA1107 KIAA1324L KIAA1549L KIF11 KIF13B KIF18A KIF21B KIFAP3 KLF15 KLF4 KLF5 KLF6 KLF7 KLHDC1 KLHDC9 KLHL5 KPNA2 KRR1 KRT19 KRT32 KRTAP1-5 KYNU L3MBTL1 LACC1 LAMB1 LARP4 LDB2 LGALS8-AS1 LGALS9C LHFP LHFPL2 LIFR LIMCH1 LINC00238 LINC00842 LINC00886 LINC00968 LINC01003 LINC01296 LINC01354 LIPC LIPH LMBR1L LMO3 LNX1 LOC100126784 LOC100130331 LOC100287387 LOC100288911 LOC100289361 LOC100419583 LOC100506100 LOC100507165 LOC101926935 LOC101927204 LOC101927811 LOC148709 LOC257396 LOC284454 LOC286254 LOC400684 LOC644936 LOC646976 LOC728705 LOC730101 LOC730102 LOC79999 LOC81691 LONRF2 LOXL4 LPAR1 LPIN1 LRBA LRIG3 LRP4 LRRC75A LRRC8C LRRC8D LRRC8E LRRK2 LRRN3 LSS LTC4S LURAP1L LXN LY96 MAGED4B MAL2 MALL MAN1A1 MANEA MANEAL MANSC1 MAP1B MAP3K12 MAP3K8 MAP4K4 MAPKAPK2 MAPRE2 MARCH2 MARCH3 MARCKSL1 MASP1 MAZ MC1R MC4R MCCC1 MCOLN2 MCTP2 MED14 MEIS1 MESDC1 MESP1 MET METTL5 METTL7A MFF MFI2 MFI2-AS1 MGARP MICAL1 MICAL2 MID1 MID1IP1 MIF4GD MIR31HG MIR4435-1HG MIR99AHG MITF MKRN3 MMP16 MORN4 MOXD1 MPP3 MROH8 MRPS6 MSC MSN MSRB3 MT1A MT1B MT1E MT1F MT1G MT1H MT1HL1 MT1L MT1M MT1X MT2A MTFP1 MTHFD2P1 MTHFR MTSS1 MXD3 MYB MYBL1 MYL2 MYL9 MYO15A MYO1E MYOZ2 N4BP2 NABP1 NACC2 NAMPT NANOS1 NAPEPLD NAPG NAV2 NAV3 NBEA NCEH1 NCKAP5 NEAT1 NEDD4 NEIL1 NET1 NEURL2 NEXN-AS1 NFE2L3 NFKBID NFKBIZ NFYB NGEF NHLRC3 NICN1 NID2 NIFK-AS1 NIPAL3 NLGN1 NLRC5 NME5 NMT2 NMU NOV NPTX1 NR2F1-AS1 NR3C1 NT5DC1 NT5E NTN4 NUAK1 NUDT12 NUP50 NYNRIN OCIAD2 OGFRL1 OR8J1 ORC4 OSBPL3 OSBPL8 OSGEPL1 OSR2 OXTR P2RX6P P4HA3 P4HTM PAMR1 PARD3 PARD6A PARP4 PARP9 PAX8-AS1 PC PCBD2 PCDH18 PCDH7 PCSK4 PCSK6 PCYOX1 PDCD2L PDE1C PDE4B PDE4DIP PDE8B PDGFD PDGFRA PDLIM2 PDP1 PDP2 PDXDC1 PDZRN3 PER3 PEX11A PGBD3 PGM3 PGPEP1 PHC2 PHF19 PHLDA1 PHLDA2 PHOSPHO2 PHYHD1 PI15 PI16 PIGL PIK3R1 PIM2 PIP PKIA PKP3 PLA2G16 PLA2G4C PLAT PLAU PLCD4 PLD6 PLEKHA4 PLEKHA6 PLEKHG4 PLGLB1 PLSCR4 PM20D2 PML PNMA6A PNMAL1 PODXL POFUT2 POLR3D PPAP2B PPAPDC1B PPAPDC2 PPFIA4 PPIP5K1 PPL PPP1R14A PPP1R18 PPP2R2D PPP4R4 PRELID2 PREPL PRIM2 PRKCA PRKCDBP PRKCI PRKCZ PRMT6 PRNP PROSC PRPS2 PRR15 PRR16 PRRT2 PRRT3 PRSS12 PRSS2 PRSS3 PRTN3 PRUNE2 PSEN2 PSIP1 PSMG3-AS1 PTGDS PTGER4 PTGFR PTGIS PTPN3 PTX3 PXDN PXK PXN PYROXD2 QKI RAB11FIP4 RAB15 RAB23 RAB38 RAC2 RAI14 RALGPS2 RAMP1 RANBP17 RANBP6 RANGAP1 RAPH1 RARA-AS1 RARRES1 RASA2 RASAL2 RASGRP1 RASGRP2 RASSF2 RASSF5 RASSF7 RASSF8 RASSF8-AS1 RBM43 RBM47 RBPMS-AS1 RCL1 RDH10 RDH5 RECK REEP2 REEP3 REEP4 RELT RFTN1 RGCC RGN RGS16 RGS17 RGS2 RGS20 RGS7BP RHOC RHOU RILP RIMBP3 RMI2 RNASEL RNASET2 RNF112 ROR1 RPS6KA6 RRBP1 RSU1 RTKN2 RTN1 RUVBL1 S1PR1 SACS SALL2 SAMD3 SAMD9 SAR1A SAYSD1 SCARA3 SCN9A SCRN3 SDC4 SDCCAG8 SDPR SEC24D SECTM1 SELENBP1 SEMA3A SEMA3B SEMA3C SEMA3D SENP5 SEPT7 SERAC1 SERPINB2 SERPINH1 SERTAD2 SESTD1 SETD5 SFR1 SFRP1 SGK1 SGSH SH2B3 SH3BGRL2 SH3D19 SH3D21 SH3KBP1 SHC4 SHMT1 SHQ1 SIN3B SIPA1L2 SIRPA SKA1 SLAMF9 SLC13A3 SLC14A1 SLC16A2 SLC16A4 SLC16A7 SLC16A9 SLC1A1 SLC1A2 SLC20A1 SLC22A15 SLC23A2 SLC25A12 SLC25A23 SLC25A25 SLC25A28 SLC25A29 SLC25A4 SLC25A40 SLC26A10 SLC2A1 SLC31A1 SLC31A2 SLC35F2 SLC35F3 SLC38A2 SLC39A8 SLC40A1 SLC43A3 SLC44A1 SLC48A1 SLC4A1 SLC5A3 SLC6A15 SLC6A6 SLC7A11 SLC7A14 SLC7A2 SLC7A4 SLC7A8 SLC8A1 SLC9A9 SLITRK4 SLX1A SMAD9 SMC4 SMC5 SMCO4 SMG1P2 SMKR1 SMPDL3A SMTN SNAPC5 SNCA SNED1 SNHG8 SNN SNTB1 SOCS1 SOCS3 SOD2 SOST SOX9 SP140L SPACA1 SPARC SPATA6 SPC24 SPEG SPIN4 SPR SPRED1 SPRY1 SPRY2 SPTLC2 SPTLC3 SQRDL SRA1 SRPX SRRM3 SSH1 SSR4P1 SSTR1 ST3GAL6 ST5 STAC STAR STARD5 STAT1 STAU2 STC1 STEAP1 STEAP2 STEAP3 STK38L STMN1 STRIP2 STXBP6 SUCNR1 SULT1A1 SULT1B1 SULT1E1 SUMF2 SUN1 SVEP1 SVIP SYBU SYNGR1 SYNGR2 SYNPO2 SYT11 SYTL2 TAGLN TANC1 TAS2R4 TBC1D12 TBC1D16 TBC1D20 TBL1XR1 TCAIM TCEA3 TEAD2 TET3 TFB1M TFDP2 TGFB1I1 TGFBR2 TGFBR3 THAP10 THAP8 THBD THBS2 THSD1 THSD4 TIAM2 TIGD7 TIMP3 TIPARP TJP2 TK1 TLE3 TLE4 TLR4 TM2D2 TM4SF1 TM7SF2 TMEFF2 TMEM106B TMEM106C TMEM130 TMEM132B TMEM155 TMEM158 TMEM159 TMEM171 TMEM192 TMEM200A TMEM25 TMEM38A TMEM51 TMEM57 TMEM92 TMTC1 TMTC2 TMTC4 TMX4 TNFAIP2 TNFAIP8 TNFRSF11B TNFRSF21 TNFRSF8 TNFSF12 TNFSF13B TNFSF14 TNFSF9 TNIK TNNC2 TNS3 TNXB TOR4A TP53INP2 TP53TG1 TP53TG3 TPBG TPCN1 TPD52L1 TPK1 TPM4 TPMT TRAPPC3L TRIB3 TRIM14 TRIM2 TRIM22 TRIM45 TRIM6 TRIOBP TSC22D1-AS1 TSHZ1 TSHZ2 TSKS TSLP TSPAN4 TSPAN8 TST TSTD3 TTC30B TTC39C TUBB TUBB2A TUBB4A TUBB6 TWSG1 TXLNG TXN TXNRD1 TYMP TYMSOS UBE2J1 UBR2 UBXN2B UGCG ULK1 USP18 USP53 UST VASN VCAM1 VEGFC VGLL3 VIT VPS13A VTI1A VWA5A VWCE WBSCR27 WDFY3-AS2 WDR36 WDR66 WHSC1 WISP2 WTAP WWC3 XG XRCC4 YPEL2 YPEL4 YRDC YWHAZ ZBTB38 ZC3H12A ZDHHC2 ZDHHC23 ZEB1 ZFHX4 ZFHX4-AS1 ZFP36 ZFPM2 ZFYVE28 ZNF106 ZNF219 ZNF331 ZNF33B ZNF365 ZNF395 ZNF41 ZNF438 ZNF467 ZNF503 ZNF546 ZNF550 ZNF638 ZNF783 ZNF814 ZSCAN16 ZSCAN31 ZSWIM3

wild type P. gingivalis strain, W50

Upregulated AADAC ABCA3 ABCA4 ABCA6 ABCA8 ABCC2 ABCC3 ABHD13 ABL1 ABLIM3 ACAN ACCS ACKR4 ACTA2 ACTBL2 ACTG2 ACTN1 ACTN3 ACTR3 ACYP1 ADA ADAM19 ADAM33 ADAMTS1 ADAMTS12 ADAMTS14 ADAMTS4 ADAMTS6 ADAMTS9 ADAMTSL1 ADARB1 ADCY4 ADD3 ADH1A ADM ADORA2A ADORA2B ADSSL1 AFAP1L2 AGFG2 AGPAT9 AGT AHNAK AHNAK2 AIF1L AKAP13 AKR1B10 AKR1C1 AKT3 ALDH1A1 ALDH1A3 ALDH6A1 ALPK2 AMD1 AMOT AMOTL1 AMPD3 AMT ANGPT1 ANGPT2 ANK1 ANK3 ANKFY1 ANKH ANKRD1 ANKRD13A ANKRD35 ANO6 ANPEP ANTXR2 ANXA10 AOC3 AOX1 AP3M2 APBB1IP APC2 APOC1 AQP1 AQP11 ARHGAP12 ARHGAP18 ARHGAP24 ARHGEF17 ARHGEF28 ARHGEF3 ARHGEF37 ARHGEF7 ARHGEF9 ARID5A ARL5B ARMCX5 ARNT2 ARPP21 ARRDC3 ARSI ART4 ARVCF ASIC1 ATF3 ATHL1 ATOH8 ATP10A ATP1A1 ATP1A4 ATP6AP1L ATP6V0E2 ATP9A ATXN1 AUH AVEN AVPI1 AXL B3GNT2 B4GALT3 BAALC BAHCC1 BATF2 BCKDHB BCL11A BCL2L11 BCL7A BDKRB1 BDKRB2 BDNF BEX1 BGN BHLHE40 BHLHE41 BLID BMF BMP4 BMP8A BNC2 BPGM BRD4 BTBD9 BTN2A2 C10orf10 C10orf54 C11orf54 C14orf132 C15orf39 C16orf45 C16orf74 C17orf58 C1GALT1 C1orf167 C1orf52 C1QTNF5 C1RL C21orf88 C2CD5 C3orf18 C5 C6orf1 C6orf165 C7orf69 C8orf48 CA12 CA4 CA5B CAB39L CABLES1 CACNA1G CACNG6 CALD1 CALHM2 CAMK2B CAMKK1 CAPRIN2 CAPS2 CARD6 CASC15 CASP1 CAST CAT CAV1 CAV3 CBLN2 CBR3 CBX7 CC2D2A CCBE1 CCBL1 CCDC102B CCDC109B CCDC125 CCDC3 CCDC81 CCDC85B CCDC88B CCK CCL1 CCL11 CCL26 CCL7 CCNYL1 CCRN4L CD200 CD302 CD34 CD3EAP CD9 CDCP1 CDH18 CDH2 CDKL5 CDKN1C CDKN2B CDON CDR2L CDX1 CEACAM1 CECR5-AS1 CELA2A CELA2B CELF2 CEMIP CENPF CFAP45 CGNL1 CH25H CHEK2 CHI3L1 CHST15 CHST2 CHST3 CHST7 CHSY1 CHSY3 CILP CISH CIT CITED2 CITED4 CLCA2 CLDN14 CLEC14A CLEC3B CLIP2 CLMP CMKLR1 CNGA1 CNIH3 CNN1 CNNM2 CNTN3 CNTNAP3 COL13A1 COL14A1 COL18A1 COL21A1 COL24A1 COL27A1 COL4A1 COL4A2 COL5A2 COL5A3 COL6A6 COL8A2 COLEC12 CORO6 COX4I2 CPA4 CPED1 CREB3L1 CREB3L4 CREBRF CRHBP CRISPLD2 CRTC3 CSGALNACT1 CSRP2 CTGF CTHRC1 CTPS1 CTSL CX3CL1 CXCL1 CXCL2 CXCL6 CXCL8 CYFIP2 CYP1A1 CYP2S1 CYP3A5 CYP3A7 CYP4X1 CYTH4 CYTL1 DAAM2 DAB2IP DACT1 DAND5 DBNDD2 DBP DCLK2 DCLRE1A DDIT4L DDR1 DDX39A DENND3 DEPTOR DHRS1 DHRS13 DHRS3 DHRS9 DIO2 DIRAS3 DISC1 DISP1 DKK1 DLC1 DMTN DNMBP DOCK4 DOCK5 DOK5 DPF3 DPH2 DPT DPYD DPYSL2 DPYSL4 DRAM1 DSE DSEL DSP DST DSTN DTWD1 DUSP4 DUSP6 DYNC1LI1 DYNC2H1 DZIP1L E2F3 E2F7 EBF1 EBF2 EBF3 ECE2 ECHDC2 EDIL3 EDN1 EDNRA EFHC1 EFNB1 EGR1 EGR2 EGR3 EHD3 EID3 EIF4EBP1 ELMSAN1 ELN EMC3-AS1 EMCN EMILIN2 EML1 ENC1 ENOX1 ENPP2 EPAS1 EPHA2 EPHA5 ERAP2 ERCC6 ESM1 ETS1 ETS2 ETV1 ETV4 EVI2A EVL EYA2 FABP5 FAM101B FAM102B FAM107A FAM109B FAM111A FAM129A FAM160B2 FAM167A FAM180A FAM182B FAM20A FAM26E FAM27C FAM27E2 FAM3C FAM81A FARP1 FAXDC2 FBLIM1 FBXL16 FERMT1 FES FGD4 FGF1 FGF13 FGF16 FGF5 FGF7 FGFR1 FGFR3 FHL2 FHL3 FHOD1 FIG4 FLNB FLOT2 FMN2 FMNL2 FMO3 FMOD FOS FOSL1 FOSL2 FOXD1 FOXF1 FOXK1 FOXO1 FRK FRMD4A FRMD5 FRMD6 FRY FST FUS FUT8 FUT8-AS1 FYCO1 FZD1 FZD4 FZD7 FZD8 G0S2 GAB1 GABRE GADD45A GADD45B GADD45G GALM GALNT12 GALNT15 GALNT2 GALNT5 GAREM GARS GAS1 GATAD2A GBP1 GBP2 GCHFR GDF10 GEM GEN1 GFOD1 GFPT2 GGTA1P GJA1 GJA4 GLI2 GLIPR2 GLIS3 GLRX GMPR GNG11 GNG2 GNPDA1 GOLT1B GPC2 GPER1 GPM6B GPR126 GPR39 GPR68 GPRASP1 GPX3 GREM1 GREM2 GSAP GSTA2 GTDC1 GUCY1A3 GUCY1B3 GULP1 GYPC H19 HBEGF HDDC3 HECTD3 HES1 HES5 HEXIM2 HEY1 HEY2 HEYL HHAT HHIP HIGD1B HILS1 HIP1R HMGA1 HMGA2 HMOX1 HNRNPAB HOXA2 HOXA3 HOXB2 HPCAL1 HRCT1 HS3ST1 HS6ST1 HS6ST3 HSD11B1 HSD17B8 HSPA12B HSPA2 HTR2B HTR7 HTRA3 ICAM2 ID2 IDH1 IDH2 IER3 IFFO1 IFI44 IFI44L IFIH1 IFIT1 IFNE IFNGR1 IFT172 IGF2 IGF2BP3 IGFBP1 IGFBP5 IKBKB IL12RB1 IL15RA IL17B IL17RC IL17RD IL18R1 IL1A IL1B IL20RB IL21R IL33 IL34 IL7 IMPA2 INHBA IQCD IRAK1BP1 IRF4 IRS2 ISG20 ISYNA1 ITGA11 ITGA2 ITGA6 ITGB3 ITGB8 ITPKB ITPR3 IVNS1ABP JADE2 JADE3 JAG1 JAM3 JARID2 JMJD6 JPH2 JUNB KALRN KANK1 KAT2B KAZALD1 KAZN KBTBD11 KBTBD3 KCNAB1 KCNB1 KCND2 KCNG1 KCNJ2 KCNK1 KCNK6 KCNMA1 KCNMB3 KCNN3 KCNN4 KCNS3 KCTD15 KCTD4 KCTD8 KIAA0020 KIAA0247 KIAA0754 KIAA1551 KIAA1683 KIAA1731NL KIAA1755 KIF13B KITLG KLF10 KLF11 KLF4 KLF7 KLF9 KLHDC9 KLHL13 KLHL41 KPNA2 KRT18 KRT18P55 KRT19 KRT34 KRT4 L3HYPDH LACC1 LAMA2 LAMA3 LAMB1 LAPTM4A LDB2 LECT2 LGALS3 LGMN LGR4 LGR5 LHFP LHFPL2 LIMCH1 LIMK2 LIMS1 LINC00152 LINC00312 LINC00341 LINC00839 LINC01003 LINC01315 LIPC LIPG LITAF LMCD1 LMO2 LMO3 LOC100130433 LOC148709 LOC389831 LOC441178 LOC646976 LOC730101 LOC81691 LONRF2 LOXL3 LOXL4 LPIN1 LPPR4 LPXN LRCH2 LRP4 LRRC32 LRRC59 LRRC75A LRRC8C LRRC8D LRRN3 LRRTM2 LSP1 LY6E LY96 LYRM4 LYRM9 LZTS1 LZTS3 MACF1 MAFB MAFK MALL MAMDC2 MAMLD1 MANSC1 MAP2K3 MAP3K15 MAP3K7CL MARCH2 MARCKSL1 MASP1 MATN3 MBP MCAM MED14OS MEF2C MEIS1 MET METTL7A MEX3B MFGE8 MFI2 MGARP MICALCL MICALL2 MIR4697HG MITF MKL1 MKL2 MLC1 MLXIP MMP1 MMP10 MMP11 MOCS1 MPG MPP1 MPRIP MRAP2 MROH8 MRPS6 MSC MSR1 MSX1 MT1A MT1B MT1E MT1L MT1M MT2A MTFP1 MTHFD2 MTSS1 MXRA5 MYH11 MYH3 MYH9 MYL2 MYL9 MYLK MYLK2 MYOC MYRIP NAB1 NACC2 NAGS NANOS1 NAV3 NBEA NCALD NCF2 NCKAP5 NDRG4 NEDD4L NEIL1 NET1 NEURL1B NEURL3 NFAT5 NFE2L3 NFIB NGEF NGFR NHLRC4 NID2 NKAIN1 NKAIN4 NLRP1 NLRP10 NMNAT2 NMT2 NOD1 NOTCH1 NOTCH4 NOX4 NOXA1 NPPB NPPC NPTX1 NR0B1 NR2F1-AS1 NREP NRG1 NRIP3 NT5E NTF4 NTN1 NTN4 NTNG2 NTRK3 NTSR1 NUAK1 NUMB NYNRIN OAF OAS1 OBFC1 OCIAD2 OLFM2 OLFM4 OLFML1 OLFML2A OLFML2B OLR1 OMD OSR1 OSR2 P2RY14 P4HA3 P4HTM PAG1 PAK3 PAMR1 PARD6A PARP9 PAWR PCDH9 PCGF3 PCNXL2 PCSK1 PCYOX1 PDE3A PDE4B PDGFA PDGFC PDGFD PDGFRA PDGFRB PDK4 PDLIM3 PDZRN3 PELO PF4 PFKL PGBD3 PGM3 PGM5P4-AS1 PGPEP1 PHLDA1 PHLDA2 PHLDB1 PHOSPHO2 PID1 PIK3C2B PIK3R1 PIM1 PITPNC1 PKIA PKNOX2 PLA2G16 PLA2G4C PLAT PLAU PLCD3 PLCE1 PLCXD3 PLD6 PLEC PLEKHA4 PLEKHA6 PLEKHG2 PLEKHG3 PLEKHG4 PLSCR4 PLXDC1 PLXND1 PMEPA1 PNMAL1 PODXL POLR3D POLR3GL POM121L9P POTEKP PPAP2A PPAPDC1A PPARGC1B PPFIBP2 PPIF PPL PPP1R3B PPRC1 PRDM8 PREB PRELID2 PREX1 PRKAB2 PRKAR2B PRKCA PRKCZ PRNP PROCR PRPH2 PRPS1 PRPS1L1 PRR5 PRR5L PRRT2 PRRT3 PRSS2 PRSS3 PRSS35 PSD3 PSEN2 PTCH2 PTGER1 PTGER2 PTGER4 PTGIS PTGS1 PTH1R PTK2 PTPLA PTPN3 PTPRK PTX3 PUS7 PXN PYCARD PYCR1 PYROXD2 RAB23 RAB27B RAB42 RABGAP1 RAD51 RADIL RAI14 RALGDS RALGPS2 RAMP1 RANBP17 RAPGEF3 RAPGEF6 RARB RARRES1 RARRES3 RASAL2 RASD1 RASGRP1 RASL11B RASSF4 RASSF5 RBM24 RBM43 RCAN1 RCAN2 RDH10 RDH5 RECK REEP2 RFC2 RFTN1 RGS17 RGS2 RHBDF1 RHBDF2 RHOJ RIBC1 RILP RIMBP3 RIN3 RIPK4 RITA1 RMI2 RNASEL RNF121 RNF122 RNF144A RNF144B RNF152 ROBO4 ROR1 RP2 RPS6KA5 RRP9 RTKN2 RTP4 RUNX1T1 RYR1 S100A3 S1PR1 S1PR5 SALL2 SAMD3 SAMD5 SAR1A SASH1 SAT1 SCARA3 SCARA5 SCD5 SCFD2 SCIN SCN8A SCN9A SDC4 SDCCAG8 SEC31B SELENBP1 SEMA3A SEMA3B SEMA3C SEMA3D SEMA3G SEMA5B SEPT3 SEPT4 SERINC5 SERPINA3 SERPINB1 SERPINE1 SERPINE2 SERTAD2 SERTAD4 SESN3 SFR1 SFRP2 SGCA SGK1 SGSH SH2D4A SH2D5 SH3BP5 SH3D19 SH3KBP1 SH3PXD2A SH3PXD2B SH3RF1 SH3RF3 SHC3 SHMT1 SHQ1 SIX1 SIX2 SLC13A4 SLC14A1 SLC15A4 SLC16A12 SLC16A14 SLC16A2 SLC18B1 SLC1A1 SLC1A2 SLC1A4 SLC20A1 SLC20A2 SLC22A15 SLC24A3 SLC25A13 SLC25A25 SLC25A29 SLC25A32 SLC26A10 SLC26A4 SLC29A1 SLC2A9 SLC30A3 SLC32A1 SLC35F2 SLC38A2 SLC38A4 SLC39A8 SLC3A2 SLC43A3 SLC47A2 SLC48A1 SLC5A6 SLC6A15 SLC6A4 SLC6A6 SLC7A14 SLC7A4 SLC7A5 SLC7A8 SLC8B1 SLC9A3R2 SLC9A9 SLCO4A1 SLITRK6 SLX1A SLX4IP SMAD3 SMAD9 SMC6 SMCO4 SMIM3 SMTN SNAI1 SNAI2 SNCA SNHG15 SNTB1 SOCS2 SOCS3 SOD2 SORBS1 SORBS2 SOST SOX17 SOX4 SOX8 SOX9 SPARCL1 SPIN4 SPOCD1 SPON2 SPP1 SPRED2 SPRY1 SPRY2 SPTLC3 SRC SRF SRGAP1 SRPX SSFA2 SSH1 SSPN SSTR1 ST3GAL2 ST3GAL5 ST3GAL6 ST5 STAB2 STAC STARD13 STARD4 STAT1 STBD1 STEAP2 STEAP3 STMN3 STX3 SULF2 SULT1B1 SULT1E1 SUN1 SVEP1 SVIL SYT1 SYT11 SYT12 SYTL2 TACC2 TAGLN TANC1 TBC1D10A TBC1D12 TBC1D2B TBX2 TCAIM TCEA3 TCF7 TCP11L2 TDO2 TEAD2 TENM4 TES TEX19 TFAP2D TFB1M TFPI TFPI2 TGFB1 TGFB2 TGFB3 TGFBI TGFBR2 TGFBR3 TGM2 THBD THBS1 THSD1 TIMP3 TIPARP TLE3 TLR1 TLR3 TM4SF1 TM7SF2 TM7SF3 TMC4 TMC6 TMEFF2 TMEM106B TMEM106C TMEM11 TMEM130 TMEM132B TMEM133 TMEM140 TMEM158 TMEM159 TMEM171 TMEM200A TMEM217 TMEM25 TMEM38A TMEM57 TMSB15A TMTC1 TMTC2 TMX4 TNFAIP2 TNFAIP3 TNFAIP8 TNFAIP8L3 TNFRSF11B TNFRSF14 TNFRSF21 TNFSF10 TNFSF12 TNFSF13B TNFSF4 TNK2 TNNC2 TNNT3 TNRC6C-AS1 TNS3 TNXB TOMM40 TOR4A TOX2 TP53INP2 TPBG TPCN1 TPD52L1 TPK1 TPM1 TPM2 TPST2 TPX2 TRAF5 TRAK1 TRAM2 TRIB1 TRIM2 TRIM34 TRIM37 TRIM5 TRIM59 TRIM6 TRIM8 TRIO TRIOBP TRPC4 TRPS1 TSPAN4 TSPAN8 TTC7A TTYH2 TUBB2A TUBB6 TXLNB TXNIP TYMSOS TYR UBA7 UBE2L6 UBE3D UBXN2B UNC13B UNC5B UPB1 UPP1 URB2 UROD USP18 USP31 USP53 VASN VASP VEGFC VEPH1 VIT VLDLR VNN2 VPS13A VSTM4 VWA5A VWCE WBSCR27 WDR54 WISP2 WLS WNT2 WWC1 XG XRCC4 XRCC6BP1 YPEL2 YRDC YWHAH ZCCHC5 ZDHHC23 ZEB2 ZFAND5 ZFHX2 ZFP36 ZMIZ1 ZMYND15 ZNF286A ZNF365 ZNF395 ZNF423 ZNF469 ZNF532 ZNF608 ZNF697 ZNF850 ZSCAN16 ZSWIM5

 

Downregulated AADAC ABCA3 ABCA6 ABCA8 ABCC2 ABCC3 ABHD13 ABL1 ABLIM3 ACCS ACKR4 ACTG2 ACTN1 ACTR3 ACYP1 ADAM33 ADAMTS1 ADAMTS12 ADAMTS6 ADAMTS9 ADAMTSL1 ADARB1 ADCY4 ADD3 ADH1A ADM ADSSL1 AFAP1L2 AGFG2 AGPAT9 AHNAK AHNAK2 AIF1L AKAP13 AKR1C1 AKT3 ALDH1A3 ALDH6A1 ALPK2 AMOT AMOTL1 AMPD3 AMT ANGPT1 ANK1 ANK3 ANKFY1 ANKH ANKRD13A ANKRD35 ANO6 ANPEP ANTXR2 ANXA10 AOC3 AOX1 AP3M2 APC2 AQP11 ARHGAP12 ARHGAP18 ARHGAP24 ARHGEF28 ARHGEF3 ARHGEF37 ARHGEF9 ARL5B ARMCX5 ARNT2 ARPP21 ARRDC3 ART4 ARVCF ASIC1 ATF3 ATHL1 ATOH8 ATP1A1 ATP1A4 ATP6V0E2 ATP9A ATXN1 AUH AVEN AVPI1 AXL B4GALT3 BATF2 BCKDHB BCL11A BCL2L11 BCL7A BDKRB1 BDKRB2 BDNF BEX1 BGN BHLHE41 BLID BMF BMP4 BMP8A BNC2 BRD4 BTBD9 BTN2A2 C10orf54 C11orf54 C14orf132 C16orf45 C16orf74 C17orf58 C1GALT1 C1orf167 C1orf52 C1RL C21orf88 C2CD5 C3orf18 C5 C6orf1 C6orf165 C8orf48 CA12 CA5B CABLES1 CACNA1G CACNG6 CALHM2 CAMK2B CAMKK1 CAPRIN2 CAPS2 CARD6 CASP1 CAST CAT CAV1 CAV3 CBR3 CBX7 CC2D2A CCBE1 CCBL1 CCDC109B CCDC125 CCDC3 CCDC81 CCDC85B CCDC88B CCK CCL26 CCL7 CCRN4L CD200 CD302 CD34 CD3EAP CD9 CDCP1 CDH18 CDH2 CDKL5 CDKN1C CDON CDR2L CEACAM1 CECR5-AS1 CELA2A CELA2B CELF2 CEMIP CENPF CFAP45 CHEK2 CHI3L1 CHST15 CHST3 CHSY1 CILP CIT CITED2 CITED4 CLCA2 CLEC14A CLEC3B CLIP2 CLMP CNGA1 CNIH3 CNTN3 CNTNAP3 COL13A1 COL14A1 COL18A1 COL24A1 COL4A2 COL5A2 COL6A6 COL8A2 COLEC12 CORO6 CPA4 CPED1 CREB3L1 CREB3L4 CREBRF CRTC3 CSGALNACT1 CTGF CTHRC1 CTPS1 CTSL CXCL6 CXCL8 CYFIP2 CYP1A1 CYP2S1 CYP3A5 CYP3A7 CYP4X1 CYTH4 CYTL1 DBP DCLRE1A DDIT4L DDR1 DDX39A DENND3 DHRS1 DHRS13 DHRS3 DHRS9 DIO2 DIRAS3 DISC1 DISP1 DKK1 DMTN DNMBP DOCK4 DOCK5 DOK5 DPF3 DPH2 DPYD DPYSL2 DPYSL4 DRAM1 DSE DSEL DST DSTN DTWD1 DUSP4 DUSP6 DYNC1LI1 DYNC2H1 DZIP1L E2F3 E2F7 EBF2 EBF3 ECE2 ECHDC2 EDIL3 EDN1 EFHC1 EGR1 EGR2 EGR3 EHD3 EID3 EIF4EBP1 ELMSAN1 EMC3-AS1 EMCN EMILIN2 EML1 ENOX1 ENPP2 EPHA2 EPHA5 ERAP2 ERCC6 ESM1 ETS2 ETV1 ETV4 EVI2A EYA2 FABP5 FAM101B FAM102B FAM107A FAM109B FAM111A FAM129A FAM160B2 FAM167A FAM180A FAM182B FAM20A FAM26E FAM27C FAM27E2 FAM3C FARP1 FAXDC2 FBLIM1 FBXL16 FERMT1 FES FGD4 FGF13 FGF16 FGF5 FGF7 FGFR1 FHL2 FHL3 FHOD1 FIG4 FLNB FLOT2 FMN2 FMNL2 FMO3 FOS FOSL1 FOXD1 FOXF1 FOXK1 FOXO1 FRMD4A FRMD5 FST FUS FUT8 FUT8-AS1 FYCO1 FZD1 FZD7 FZD8 GAB1 GABRE GADD45B GADD45G GALM GALNT12 GALNT15 GALNT2 GALNT5 GAREM GARS GAS1 GATAD2A GBP2 GCHFR GDF10 GEM GFOD1 GFPT2 GJA1 GLI2 GLIPR2 GLIS3 GLRX GMPR GNG11 GNPDA1 GOLT1B GPC2 GPER1 GPM6B GPR39 GPR68 GPX3 GREM1 GREM2 GSAP GTDC1 GULP1 GYPC HDDC3 HECTD3 HEXIM2 HHAT HHIP HIGD1B HIP1R HMGA1 HMGA2 HMOX1 HNRNPAB HOXA2 HOXA3 HOXB2 HPCAL1 HRCT1 HS3ST1 HS6ST1 HS6ST3 HSD17B8 HSPA12B HTR2B HTR7 ICAM2 ID2 IDH1 IDH2 IFFO1 IFI44 IFI44L IFIH1 IFIT1 IFNE IFT172 IGF2 IGF2BP3 IGFBP1 IGFBP5 IKBKB IL12RB1 IL15RA IL17RC IL17RD IL1A IL20RB IL21R IL7 IMPA2 IRAK1BP1 IRF4 IRS2 ITGA11 ITGA2 ITGA6 ITGB8 ITPKB ITPR3 JADE2 JADE3 JAM3 JARID2 JMJD6 JUNB KALRN KANK1 KAT2B KAZALD1 KBTBD11 KBTBD3 KCNAB1 KCNB1 KCND2 KCNG1 KCNJ2 KCNK1 KCNK6 KCNMA1 KCNMB3 KCNN4 KCNS3 KCTD15 KCTD4 KCTD8 KIAA0020 KIAA0754 KIAA1551 KIAA1683 KIAA1731NL KIF13B KITLG KLF10 KLF11 KLF4 KLF7 KLHDC9 KLHL13 KLHL41 KRT19 KRT34 KRT4 L3HYPDH LACC1 LAMA2 LAMA3 LAMB1 LAPTM4A LDB2 LGALS3 LGMN LGR4 LGR5 LHFP LHFPL2 LIMCH1 LIMK2 LINC00152 LINC00341 LINC00839 LINC01003 LINC01315 LIPC LITAF LMO3 LOC100130433 LOC148709 LOC389831 LOC646976 LOC730101 LOC81691 LONRF2 LOXL3 LOXL4 LPIN1 LPXN LRCH2 LRP4 LRRC59 LRRC75A LRRC8C LRRC8D LRRN3 LRRTM2 LSP1 LY6E LY96 LYRM4 LYRM9 LZTS3 MACF1 MAFB MALL MAMDC2 MANSC1 MAP2K3 MAP3K15 MAP3K7CL MARCH2 MARCKSL1 MASP1 MATN3 MED14OS MEIS1 MET METTL7A MFGE8 MGARP MICALCL MICALL2 MIR4697HG MITF MKL1 MLC1 MMP1 MMP10 MMP11 MOCS1 MPG MPP1 MPRIP MRAP2 MROH8 MRPS6 MSR1 MSX1 MT1A MT1B MT1E MT1L MT1M MT2A MTFP1 MTSS1 MYH11 MYH3 MYH9 MYL2 MYL9 MYLK MYOC MYRIP NACC2 NAGS NANOS1 NAV3 NBEA NCF2 NCKAP5 NDRG4 NEDD4L NEIL1 NET1 NEURL3 NFAT5 NFE2L3 NFIB NGEF NHLRC4 NID2 NKAIN1 NKAIN4 NLRP1 NMNAT2 NMT2 NOXA1 NPPB NPTX1 NR0B1 NR2F1-AS1 NRG1 NRIP3 NT5E NTNG2 NTRK3 NTSR1 NUMB NYNRIN OAF OAS1 OBFC1 OCIAD2 OLFM4 OLFML1 OLR1 OMD OSR1 OSR2 P4HA3 P4HTM PAK3 PAMR1 PARD6A PARP9 PAWR PCDH9 PCGF3 PCNXL2 PCYOX1 PDE3A PDE4B PDGFC PDGFD PDGFRA PDK4 PDZRN3 PELO PFKL PGBD3 PGM3 PGPEP1 PHLDA1 PHOSPHO2 PID1 PIK3R1 PIM1 PITPNC1 PKIA PLA2G16 PLA2G4C PLAT PLAU PLCD3 PLCE1 PLCXD3 PLD6 PLEC PLEKHA4 PLEKHA6 PLEKHG4 PLSCR4 PLXND1 PNMAL1 PODXL POLR3D POLR3GL POTEKP PPAP2A PPAPDC1A PPL PPP1R3B PPRC1 PRDM8 PRELID2 PREX1 PRKAB2 PRKAR2B PRKCA PRKCZ PRNP PROCR PRPH2 PRPS1 PRPS1L1 PRR5 PRRT2 PRRT3 PRSS2 PRSS3 PSD3 PSEN2 PTGER1 PTGER2 PTGER4 PTGIS PTGS1 PTPLA PTPN3 PTPRK PTX3 PUS7 PXN PYCARD PYCR1 PYROXD2 RAB23 RAB27B RAB42 RAD51 RADIL RALGDS RALGPS2 RAMP1 RANBP17 RAPGEF3 RAPGEF6 RARB RARRES1 RARRES3 RASAL2 RASGRP1 RASSF4 RASSF5 RBM24 RBM43 RCAN1 RCAN2 RDH10 RDH5 RECK REEP2 RFC2 RFTN1 RGS17 RGS2 RHBDF1 RHOJ RIBC1 RILP RIMBP3 RITA1 RMI2 RNASEL RNF121 ROBO4 RP2 RPS6KA5 RRP9 RTKN2 RTP4 RUNX1T1 RYR1 S1PR1 SALL2 SAMD3 SAR1A SAT1 SCARA3 SCARA5 SCFD2 SCIN SCN8A SCN9A SDC4 SDCCAG8 SEC31B SELENBP1 SEMA3A SEMA3B SEMA3C SEMA3D SERINC5 SERPINB1 SERPINE1 SERPINE2 SERTAD2 SERTAD4 SESN3 SFR1 SFRP2 SGCA SGSH SH2D4A SH2D5 SH3BP5 SH3D19 SH3KBP1 SH3PXD2A SH3PXD2B SH3RF1 SH3RF3 SHC3 SHMT1 SHQ1 SIX1 SLC13A4 SLC14A1 SLC16A14 SLC16A2 SLC18B1 SLC1A1 SLC1A2 SLC20A1 SLC20A2 SLC22A15 SLC24A3 SLC25A13 SLC25A25 SLC25A29 SLC25A32 SLC26A10 SLC26A4 SLC2A9 SLC32A1 SLC35F2 SLC38A2 SLC38A4 SLC39A8 SLC3A2 SLC43A3 SLC47A2 SLC48A1 SLC5A6 SLC6A15 SLC6A4 SLC6A6 SLC7A14 SLC7A4 SLC7A8 SLC9A3R2 SLC9A9 SLCO4A1 SLITRK6 SLX1A SLX4IP SMAD3 SMAD9 SMCO4 SMIM3 SNAI1 SNCA SNHG15 SNTB1 SOCS3 SOD2 SORBS1 SOST SOX17 SOX8 SOX9 SPARCL1 SPIN4 SPRED2 SPRY1 SPRY2 SPTLC3 SRC SRF SRGAP1 SRPX SSFA2 SSPN SSTR1 ST3GAL5 ST3GAL6 ST5 STAB2 STAC STARD13 STARD4 STAT1 STBD1 STEAP2 STEAP3 STMN3 STX3 SULF2 SULT1B1 SULT1E1 SUN1 SVEP1 SVIL SYT1 SYT11 SYT12 TACC2 TAGLN TANC1 TBC1D10A TBC1D12 TBC1D2B TCAIM TCEA3 TCF7 TEAD2 TENM4 TES TEX19 TFAP2D TFB1M TFPI2 TGFB2 TGFBI TGFBR2 TGFBR3 TGM2 THBD THBS1 THSD1 TIMP3 TIPARP TLE3 TLR1 TLR3 TM4SF1 TM7SF2 TM7SF3 TMEFF2 TMEM106B TMEM106C TMEM11 TMEM130 TMEM132B TMEM140 TMEM158 TMEM159 TMEM171 TMEM200A TMEM25 TMEM38A TMEM57 TMSB15A TMTC1 TMTC2 TMX4 TNFAIP2 TNFAIP3 TNFAIP8 TNFAIP8L3 TNFRSF11B TNFRSF14 TNFRSF21 TNFSF10 TNFSF12 TNFSF13B TNK2 TNNC2 TNNT3 TNRC6C-AS1 TNXB TOMM40 TOR4A TOX2 TP53INP2 TPBG TPCN1 TPD52L1 TPK1 TPM2 TRAF5 TRAK1 TRAM2 TRIM2 TRIM34 TRIM37 TRIM59 TRIM8 TRIO TRIOBP TRPC4 TRPS1 TSPAN4 TSPAN8 TTC7A TUBB2A TUBB6 TXLNB TXNIP TYMSOS TYR UBA7 UBE2L6 UBXN2B UNC13B UPP1 URB2 UROD USP18 USP31 USP53 VASN VASP VEGFC VEPH1 VIT VNN2 VPS13A VWA5A VWCE WBSCR27 WDR54 WISP2 WLS WNT2 WWC1 XG XRCC6BP1 YRDC YWHAH ZDHHC23 ZFAND5 ZFHX2 ZFP36 ZMIZ1 ZMYND15 ZNF286A ZNF365 ZNF395 ZNF532 ZNF608 ZNF697 ZNF850 ZSCAN16 ZSWIM5

wild type P. gingivalis strain 381 Upregulated ABCA4 ACTA2 ADA ADAM19 ADAMTS14 ADAMTS4 ADORA2A ADORA2B AGT AKAP13 AKR1B10 ALDH1A1 ALPK2 ALPL ANGPT2 ANKRD1 APBB1IP APOC1 AQP1 ARHGEF17 ARHGEF7 ARHGEF9 ARID5A ARSI ATF3 ATHL1 ATP10A ATP1A1 ATP1A4 ATP6AP1L BAALC BAHCC1 BGN BHLHE40 BMP8A BPGM C15orf39 C1QTNF5 C7orf69 CA4 CAB39L CALD1 CASC15 CBLN2 CCDC102B CCDC81 CCL1 CCL11 CCNYL1 CDKN2B CDR2L CDX1 CGNL1 CHIT1 CHST2 CHST7 CHSY1 CHSY3 CISH CLDN14 CMKLR1 CNN1 CNNM2 COL18A1 COL21A1 COL27A1 COL4A1 COL4A2 COL5A3 COX4I2 CRHBP CRISPLD2 CSRP2 CTGF CX3CL1 CXCL1 CXCL2 CXCL6 DAAM2 DAB2IP DACT1 DAND5 DBNDD2 DCLK2 DEPTOR DLC1 DPT DSP EBF1 EDNRA EFHD1 EFNB1 EIF4EBP1 ELN ENC1 ENPP2 EPAS1 ETS1 EVL FAM222A FAM26E FARP1 FGFR3 FMOD FOSL2 FRY FZD4 G0S2 GADD45A GADD45B GBP1 GEN1 GGTA1P GJA4 GNG2 GPR126 GPRASP1 GSTA2 GUCY1A3 GUCY1B3 H19 HBEGF HES1 HES5 HEY1 HEY2 HEYL HILS1 HSD11B1 HSPA2 HTRA3 IER3 IFNGR1 IGF2 IL17B IL18R1 IL1B IL21R IL33 IL34 INHBA IQCD ISG20 ISYNA1 ITGA11 ITGB3 IVNS1ABP JAG1 JARID2 JPH2 JUNB KAZN KCNG1 KCNN3 KCTD15 KIAA0247 KIAA1755 KLF9 KPNA2 KRT18 KRT18P55 LAMB1 LECT2 LGMN LHFPL2 LIMK2 LINC00312 LINC00839 LIPG LMCD1 LOC441178 LOXL3 LPPR4 LRRC32 LZTS1 MAFK MAMLD1 MARCKSL1 MBP MCAM MEF2C MEX3B MICALL2 MKL2 MLXIP MMP11 MOCS1 MSC MTHFD2 MXRA5 MYLK2 NAB1 NCALD NEURL1B NGFR NOD1 NOTCH1 NOTCH4 NOX4 NPPC NR2F1-AS1 NREP NTF4 NTN4 NUAK1 OLFM2 OLFML2A OLFML2B P2RY14 P4HA3 PAG1 PCSK1 PDGFA PDGFRB PDLIM3 PF4 PHLDA2 PHLDB1 PITX2 PKNOX2 PLEKHG2 PLEKHG3 PLXDC1 PMEPA1 POM121L9P POTEKP PPAPDC1A PPARGC1B PPFIBP2 PPIF PPP1R3B PREB PRR5 PRR5L PRSS35 PTCH2 PTH1R PTK2 PYCR1 RAI14 RASD1 RASL11B RASSF4 RHBDF2 RIN3 RIPK4 RNF122 RNF144A RNF152 ROR1 S100A3 S1PR5 SAMD5 SASH1 SCD5 SEMA3G SEMA5B SEPT4 SEPT5 SERPINA3 SERPINE1 SGCA SGK1 SIX2 SLC15A4 SLC16A12 SLC1A4 SLC26A10 SLC29A1 SLC30A3 SLC3A2 SLC7A5 SMC6 SMTN SNAI1 SNAI2 SOCS2 SORBS2 SOX4 SPOCD1 SPON2 SPP1 SSH1 ST3GAL2 SULF2 SYTL2 TBC1D2B TBX2 TDO2 TEX19 TFPI TGFB1 TGFB3 TMC4 TMC6 TMEM133 TMEM217 TNFSF4 TNN TNNT3 TNS3 TPCN1 TPM1 TPST2 TPX2 TRIB1 TRIM34 TRIM5 TRIM6 TSPAN11 TTYH2 UBE3D UNC5B UPB1 VLDLR VSTM4 WWC1 XAF1 XRCC4 YPEL2 YRDC ZCCHC5 ZEB2 ZNF423 ZNF469 ZNF527 downregulated AADAC ABCA11P ABCA3 ABCA6 ABCA8 ABCB7 ABCC2 ABCC3 ABCC9 ABLIM1 ACAD11 ACAN ACAT1 ACBD5 ACHE ACKR4 ACOX3 ACSF2 ACTB ACTBL2 ACTG2 ACTN1 ACYP1 ADAM33 ADAMTS1 ADAMTS3 ADAMTS6 ADAMTS9 ADAMTSL1 ADARB1 ADCY4 ADD1 ADD3 ADH1A ADH1C ADM AEBP1 AFAP1L2 AFF1 AGBL2 AGFG2 AGPAT9 AHNAK AHNAK2 AIF1L AK3 AKAP12 AKR1C1 ALDH1A3 ALDH3A1 ALDH6A1 ALMS1 ALMS1P ALPK1 AMD1 AMOT AMPD3 ANAPC1 ANGPT1 ANGPTL1 ANK3 ANKFY1 ANKH ANKRD12 ANKRD13A ANKRD35 ANKRD37 ANKRD53 ANO3 ANO6 ANP32E ANPEP ANTXR2 ANXA10 ANXA3 AOC3 AOX1 AP3M2 APC2 APEX2 APOBEC3C APOBEC3F APOL6 APOLD1 APPL1 APPL2 AQP3 ARFGAP1 ARHGAP12 ARHGAP18 ARHGAP24 ARHGAP29 ARHGEF2 ARHGEF28 ARHGEF3 ARHGEF37 ARL4A ARL5B ARL6IP5 ARMCX5 ARPIN ARPP21 ARRDC3 ART4 ARVCF ASIC1 ASNS ASPA ASPH ASPM ATG9B ATOH8 ATP13A2 ATP2A3 ATP6V0B ATP6V0E2 ATP8B2 ATP9A ATXN1 AUH AVEN AVPI1 AXL AZIN2 B3GALT4 B3GNT1 B3GNT2 B4GALT2 B4GALT3 BACH1 BAI3 BATF2 BATF3 BCKDHB BCL11A BCL2A1 BCL2L11 BCL7A BCL9L BCLAF1 BDKRB1 BDKRB2 BDNF BEND6 BEND7 BET1L BEX1 BHLHE41 BIRC3 BIVM BLID BMF BMP1 BMP4 BNC2 BOD1L1 BOP1 BRMS1 BRPF3 BTBD9 BTN2A2 BVES BYSL C10orf10 C10orf107 C10orf54 C11orf54 C12orf65 C14orf132 C16orf45 C16orf74 C17orf58 C1GALT1 C1GALT1C1 C1orf167 C1orf21 C1RL C21orf88 C2CD2 C2CD5 C2orf73 C2orf74 C3orf18 C3orf58 C4orf17 C4orf33 C5 C6orf1 CA11 CA12 CA2 CA5B CABLES1 CACNA1G CACNB1 CACNG6 CAD CALHM2 CAMK2A CAMK2B CAMK2G CAMKK1 CAPRIN2 CAPS2 CARD6 CASP1 CAT CAV1 CAV2 CAV3 CBR3 CBX1 CBX7 CC2D2A CCBE1 CCBL1 CCDC109B CCDC115 CCDC125 CCDC132 CCDC136 CCDC25 CCDC3 CCDC69 CCDC85B CCK CCL2 CCL7 CCNG1 CCRN4L CD109 CD200 CD302 CD34 CD3EAP CD82 CD9 CDC14C CDCA2 CDCP1 CDH11 CDH18 CDH2 CDKL5 CDKN1B CDON CDRT1 CEACAM1 CECR5-AS1 CELA2A CELA2B CELF2 CEMIP CENPF CENPJ CEP250 CEP85L CHEK2 CHI3L1 CHPF2 CHRNA1 CHRNB1 CHST15 CHST3 CHST6 CILP CIRH1A CIT CITED2 CITED4 CLCA2 CLDN1 CLEC18B CLEC3B CLIC4 CLIP2 CLMP CMAHP CNGA1 CNIH3 CNTN3 CNTNAP3P2 COL13A1 COL14A1 COL24A1 COL5A1 COL5A2 COL6A6 COL8A2 COLEC12 CORO6 COTL1 CPA4 CPED1 CPT1A CREB3L1 CREB3L4 CREBRF CRLF2 CRTC3 CSF1R CSGALNACT1 CSH1 CSPP1 CT47A11 CTH CTHRC1 CTPS1 CTSC CTSH CTSL CTSV CUX2 CWC22 CXCL3 CXCL8 CYB561 CYB5A CYBRD1 CYFIP2 CYP1A1 CYP27B1 CYP2S1 CYP3A5 CYP4X1 CYR61 CYTH4 CYTL1 DAGLA DBNDD1 DBP DCBLD2 DCLRE1A DDAH1 DDIT4 DDIT4L DDR1 DDX17 DDX39A DDX41 DENND3 DEPDC7 DHDDS DHFRL1 DHRS1 DHRS13 DHRS3 DHRS9 DICER1-AS1 DIO2 DIRAS3 DISC1 DISP1 DLEU1 DLGAP4 DMTN DNAJB12 DNAJC28 DNMBP DNPEP DOCK11 DOCK3 DOCK4 DOCK5 DOK1 DOK5 DOPEY2 DPF3 DPH2 DPH6 DPYD DPYSL2 DPYSL4 DRAM1 DSE DSEL DST DSTN DTWD1 DTWD2 DUSP6 DVL3 DYNC1LI1 DYNC2H1 EBF2 EBF3 EBPL ECE2 ECHDC2 EDIL3 EDN1 EFHB EFHC1 EGLN1 EGR1 EGR3 EHBP1 EHD3 EID3 EIF4G3 ELFN2 ELMSAN1 EMCN EMILIN2 EN1 ENOX1 ENPP1 ENTPD7 EPHA2 EPHA4 EPHA5 ERAP2 ERC2 ERCC6 EREG ERLIN2 ETS2 ETV1 ETV4 EVI2A EVI2B EXOC6 EYA2 F8 FAM101B FAM102B FAM107A FAM109B FAM111A FAM129A FAM155A FAM160B2 FAM161A FAM162A FAM167A FAM171B FAM180A FAM182B FAM20A FAM213A FAM217B FAM27C FAM27E2 FAM3C FAM45B FAM63B FAM72D FAM81A FAM8A1 FANCC FAT1 FAXDC2 FBLIM1 FBLN5 FBXL16 FEN1 FER1L6-AS1 FERMT1 FGF1 FGF13 FGF16 FGF5 FGF7 FGFR1 FHL2 FHL3 FHOD1 FIG4 FIP1L1 FLJ12825 FMN2 FMNL2 FMO3 FOS FOSL1 FOXD1 FOXD2 FOXF1 FOXG1 FOXK1 FOXQ1 FRK FRMD4A FRMD5 FRMD6 FRRS1 FST FSTL1 FUCA1 FUS FUT8 FUT8-AS1 FUZ FYCO1 FZD1 FZD7 FZD8 FZD9 GAB1 GABBR1 GADD45G GAL3ST4 GALM GALNT12 GALNT15 GALNT5 GALR2 GAMT GAREM GARS GAS1 GAS2L2 GBA2 GBP2 GCHFR GDF10 GEM GFOD1 GJA1 GLI2 GLIS1 GLIS3 GLRX GM2A GMPR GNG11 GOLGA7 GOLGA8EP GPATCH1 GPATCH4 GPC1 GPC2 GPC6 GPER1 GPM6B GPNMB GPR32 GPR68 GPRC5A GPRC5B GPRC5C GPX3 GRAMD3 GREM2 GRM8 GSAP GSN GTDC1 GULP1 H1FNT HAND2 HAPLN1 HAUS7 HCN3 HDAC9 HDDC3 HEXIM2 HGS HHAT HIGD1B HIP1 HIST1H1A HIST1H1D HIST1H1E HIST1H4F HIST1H4H HIST1H4I HIST1H4J HIST1H4K HIST2H4B HMGA1 HMGA2 HMGN3 HMOX1 HNRNPA3 HNRNPAB HNRNPDL HOOK2 HOXA2 HOXA3 HOXB5 HPDL HPS3 HRCT1 HS3ST1 HS6ST1 HS6ST3 HSD17B6 HSD17B8 HSP90AA1 HSP90AA2 HSPA12B HSPA1A HSPA4L HSPB7 HTR2B HTR7 HUWE1 IARS ICAM2 ID2 ID3 IDH1 IDH2 IFFO1 IFI16 IFI44 IFI44L IFIH1 IFIT1 IFIT2 IFNE IFRD2 IGF2BP3 IGFBP1 IGFBP5 IKBKB IL12RB1 IL15RA IL16 IL17D IL17RD IL1A IL1R1 IL20RB IL27RA IL32 IL6 IL7 IMP4 ING5 IPO4 IQSEC2 IRAK1BP1 IRF2BPL IRF4 IRS2 ITGA2 ITGA3 ITGA5 ITGA6 ITGB8 ITM2B ITPKB ITPR3 JADE2 JADE3 JAM3 JMJD6 KALRN KANK1 KAT2B KAZALD1 KBTBD11 KBTBD3 KCNB1 KCNJ2 KCNK1 KCNK6 KCNMA1 KCNN4 KCNS3 KCTD16 KCTD4 KCTD7 KCTD8 KDSR KIAA0020 KIAA0101 KIAA0513 KIAA1143 KIAA1217 KIAA1324L KIAA1377 KIAA1551 KIAA1683 KIF11 KIF13B KLF10 KLF4 KLF5 KLF7 KLHDC1 KLHDC8B KLHDC9 KLHL1 KLHL13 KLHL41 KLRG1 KMT2A KMT2E KPNA5 KRT19 KRT34 KRT4 KRTAP1-5 L3HYPDH LAMA2 LAMA3 LAPTM4A LCE2B LDB2 LEPR LETM1 LGALS3 LGR5 LHFP LIF LIMS1 LINC00152 LINC00341 LINC01003 LIPC LMO2 LMO3 LNX1 LOC100130433 LOC100131564 LOC100131929 LOC148709 LOC220077 LOC285074 LOC389831 LOC644936 LOC646976 LOC730101 LOC81691 LONRF2 LOXL4 LPIN1 LPXN LRP4 LRRC59 LRRC75A LRRC8C LRRC8D LRRN3 LRRTM2 LSP1 LUZP2 LY6E LY96 LYRM4 LYRM5 LYRM9 LZTR1 LZTS3 MAB21L2 MACF1 MAFB MAFF MAGED4B MALL MAMDC2 MAMDC4 MAN2A1 MANSC1 MAP2K3 MAP7D1 MAPK10 MAPKAPK2 MARCH3 MARS MASP1 MAST4 MB21D2 MBOAT2 MCM4 ME3 MECOM MED14OS MED15 MED8 MEDAG MEGF6 MET METTL1 METTL14 METTL21A METTL7A MFGE8 MFI2 MGARP MICALCL MIER1 MIR4697HG MITF MKL1 MLC1 MMP1 MMP16 MMP19 MPDZ MPP1 MPP3 MPRIP MRAP2 MRGPRF MROH8 MRPS6 MSMB MSN MSR1 MSRA MSX1 MT1A MT1B MT1E MT1L MT1M MT2A MTFP1 MTHFR MTSS1 MX2 MYBBP1A MYBPC3 MYH3 MYH9 MYL2 MYL9 MYO19 MYO5A MYOC MYRIP NAA40 NABP1 NACAP1 NACC2 NAGS NANOS1 NAT9 NAV3 NBEA NCKAP5 NCOR1 NCOR1P1 NDRG4 NDUFA4L2 NEDD4L NEDD9 NEIL3 NET1 NEURL2 NEURL3 NFAT5 NFE2L3 NGEF NHLRC4 NID2 NIPAL2 NKAIN1 NKAIN4 NLE1 NLGN1 NLGN4Y NLRC5 NLRP1 NLRP10 NME5 NMNAT2 NMT2 NOL6 NOP2 NPC1 NPPB NPTX1 NR0B1 NRG1 NRGN NRIP3 NRROS NT5DC2 NT5E NTF3 NTN1 NTNG2 NTSR1 NUCB2 NXN NYNRIN OAF OBFC1 OBSCN OCIAD2 ODF2 ODF3L2 OLA1 OLFM1 OLFML1 OLFML3 OMD OR2W3 OSBPL8 OSR1 OSR2 OXNAD1 PACSIN2 PAK3 PALMD PAMR1 PARD6A PARP14 PARP4 PARP9 PCDH9 PCGF3 PCK2 PCNXL2 PCP2 PCSK6 PCYOX1 PDCD7 PDE10A PDE3A PDE4B PDE4DIP PDGFC PDGFD PDGFRA PDGFRL PDIK1L PDK4 PDLIM7 PDSS1 PDZRN3 PECR PELO PER3 PERP PES1 PFN4 PGAM5 PGBD3 PGM3 PGM5P4-AS1 PGPEP1 PHF20 PHF6 PHLDA1 PHOSPHO2 PHYH PID1 PIK3C2B PIK3R1 PITRM1 PKIA PKIB PKN2 PLA2G16 PLA2G2A PLA2G4C PLA2R1 PLAT PLAU PLCD3 PLCE1 PLCXD3 PLD6 PLEKHA4 PLEKHA6 PLEKHG4 PLIN3 PLSCR1 PLSCR4 PLXND1 PNKD PNMAL1 PNO1 PODXL POFUT2 POLR3D POLR3GL POMT2 PPAN PPAP2A PPAP2B PPFIA4 PPFIBP1 PPIP5K1 PPL PPP1R13L PPP1R14C PPP3CC PPRC1 PRDM8 PRELID2 PREX1 PRIM2 PRKAB2 PRKAR2B PRKCE PRKCZ PRMT2 PRNP PROSC PROSER3 PRPH2 PRPS1 PRPS1L1 PRR14 PRRT2 PRRT3 PRSS1 PRSS2 PRSS3 PSAT1 PSD3 PSEN2 PTGER1 PTGER2 PTGER4 PTGIS PTN PTPLAD1 PTPN14 PTPRB PTTG1IP PTX3 PUS1 PUS7 PVR PVRL2 PWWP2B PXN PYCARD PYROXD2 QSOX1 RAB27B RABGAP1 RAD51 RADIL RALA RALBP1 RALGDS RALGPS2 RAMP1 RANBP17 RAPGEF3 RAPGEF6 RARRES1 RARRES3 RASAL2 RASL10B RASSF5 RBM24 RBM43 RBP1 RCAN1 RCAN2 RCL1 RDH10 RDH5 RECK REEP2 REEP4 RELT RFC2 RFTN1 RGMB RGN RGS17 RGS2 RIBC1 RILP RIMBP3 RMI2 RNASET2 RNF144B RNF145 ROBO4 RP2 RPS6KA5 RPS6KA6 RRAD RRAGC RRH RRP9 RSRP1 RTKN2 RTN3 RTP4 RUNX1 RXFP4 S100P S1PR1 SALL2 SAMD3 SAMD7 SAMD9 SAMHD1 SAR1A SCAI SCARA3 SCARA5 SCARNA17 SCIN SCN3A SCN5A SCN8A SCN9A SCP2 SCRN3 SDC4 SDCBP SDCCAG8 SDPR SEC24D SECTM1 SELENBP1 SEMA3A SEMA3B SEMA3C SEMA3D SEPT7P2 SERINC5 SERPINE2 SERPINI2 SERTAD2 SERTAD4 SESN3 SFR1 SFRP2 SGIP1 SH2D4A SH2D5 SH3BP5 SH3D19 SH3D21 SH3KBP1 SH3PXD2A SH3PXD2B SH3RF3 SHC3 SHC4 SHMT1 SHMT2 SHQ1 SIGLEC17P SIRT4 SIX1 SKIL SLC12A2 SLC12A3 SLC13A4 SLC14A1 SLC16A14 SLC16A2 SLC16A7 SLC16A9 SLC18B1 SLC1A1 SLC1A2 SLC20A1 SLC20A2 SLC22A15 SLC23A2 SLC24A3 SLC25A13 SLC25A23 SLC25A25 SLC25A27 SLC25A29 SLC25A4 SLC26A4 SLC27A3 SLC27A4 SLC2A3 SLC2A9 SLC35A2 SLC35C1 SLC35F2 SLC38A2 SLC38A5 SLC39A8 SLC44A1 SLC45A2 SLC47A2 SLC48A1 SLC4A2 SLC5A6 SLC6A15 SLC6A4 SLC6A6 SLC7A1 SLC7A14 SLC7A4 SLC7A8 SLC8B1 SLC9A3R2 SLC9A9 SLCO4A1 SLIT2 SLX1A SMAD1 SMAD3 SMAD5-AS1 SMAD7 SMAD9 SMARCA2 SMARCE1 SMCO4 SMG1P1 SMIM3 SMPDL3A SNCA SNCAIP SNHG15 SNTB1 SNX11 SNX29P1 SOAT2 SOCS3 SOD2 SOHLH2 SORD SOST SOX17 SOX8 SOX9 SP3 SPAG16 SPARCL1 SPC24 SPDL1 SPECC1 SPIN4 SPNS1 SPRED2 SPRN SPRY1 SPRY2 SPTLC2 SPTLC3 SRA1 SRFBP1 SRGAP1 SRGN SRM SRPK2 SRPRB SRPX SSFA2 SSPN SSTR1 SSUH2 ST3GAL5 ST3GAL6 ST5 STAC STARD4 STAT1 STAU2 STBD1 STC1 STC2 STEAP2 STEAP3 STK24 STK4 STMN3 STX17-AS1 STX3 STXBP5 SULT1B1 SULT1E1 SUN1 SVEP1 SVIL SYDE1 SYNC SYNE3 SYT1 SYT11 SYT12 TACC2 TAGLN TANC1 TAS1R2 TAS2R40 TAS2R50 TBC1D10A TBC1D12 TBC1D22B TBC1D4 TBXA2R TCAIM TCEA3 TCF12 TCF7 TCP11L2 TEAD2 TEAD4 TENM4 TES TEX29 TFAP2D TFB1M TFPI2 TGFBI TGFBR2 TGFBR3 TGM2 THBD THBS1 THEMIS2 THSD1 TIMM17A TIMM44 TIMP3 TIPARP TLK1 TLN1 TLR1 TLR4 TM7SF2 TM7SF3 TMED9 TMEFF2 TMEM104 TMEM106B TMEM106C TMEM11 TMEM130 TMEM132A TMEM132B TMEM135 TMEM14A TMEM158 TMEM159 TMEM171 TMEM198 TMEM200A TMEM25 TMEM38A TMEM57 TMSB15A TMTC1 TMTC2 TMX4 TNFAIP2 TNFAIP3 TNFAIP6 TNFAIP8 TNFAIP8L3 TNFRSF11B TNFRSF14 TNFRSF1B TNFRSF21 TNFSF10 TNFSF12 TNFSF13B TNIK TNNC2 TNRC6C-AS1 TNXB TOB1 TOMM40 TOPORS TOR4A TOX2 TPD52L1 TPK1 TPM2 TRAF4 TRAF5 TRAK1 TRIB3 TRIM2 TRIM23 TRIM27 TRIM37 TRIM38 TRIM59 TRIM8 TRIO TRIOBP TRMT1 TROAP TRPM3 TRPS1 TSHZ1 TSPAN4 TSPAN8 TTC14 TUBA1A TUBA1B TUBA1C TUBA3C TUBB TUBB2A TUBB6 TULP1 TWSG1 TXLNB TXLNG TXNIP TYMSOS TYR UBALD1 UBD UBQLNL UBXN2B UCK2 ULK1 UPP1 USP31 USP53 UST UTP23 VAMP1 VASN VCAN VEGFA VEGFC VEPH1 VIT VLDLR-AS1 VNN2 VPS13A VWA5A VWCE WBSCR27 WDFY1 WDR54 WDR63 WHSC1 WIPI1 WISP1 WISP2 WLS WNT2 WNT2B WNT5B WWTR1 XAGE2 XBP1 XG XPO6 XRCC6BP1 YARS YIF1A ZBED4 ZDHHC21 ZDHHC23 ZFAND5 ZFC3H1 ZFHX4-AS1 ZFP14 ZFP36 ZHX1 ZHX3 ZMIZ1 ZMYND15 ZNF207 ZNF22 ZNF263 ZNF286A ZNF365 ZNF395 ZNF396 ZNF438 ZNF521 ZNF540 ZNF550 ZNF608 ZNF638 ZNF658B ZNF672 ZNF697 ZNF737 ZNF783 ZNF841 ZNF850 ZSCAN16 ZSWIM5

wild type P. gingivalis strain E8

upregulated GADD45B ID3 IL6 NOX4 NUAK1 RASL11B SERPINE1

downregulated ACTA2 ACTBL2 ACTG2 ADAM33 ANKRD1 ARHGAP6 ATP10A BDKRB2 BHLHE40 BHLHE41 BMP6 CA12 CD3EAP CDH6 CIT CNN1 COLGALT2 CSRP2 CTGF CYR61 DACT1 DENND2A DKK1 DLX2 DOCK4 DUSP6 ENC1 EVI2A FABP5 FRMD4A GALNT15 GBP1 GPSM2 GREM2 HRCT1 HS3ST1 HSPB7 ID1 IL21R IRF4 ITPKB KLHL1 LBH LINC00341 LMCD1 MEDAG MEX3B MIR4697HG MME NPTX1 NR0B1 PDK4 PITX2 PLAU PMEPA1 POTEKP PPAPDC1A PPP1R13L PRPS1 PRPS1L1 PXDC1 RTP4 RUNX1 SCARA5 SKIL SLC1A2 SLC6A15 SLC6A6 SLC7A8 SLC9A9 SLCO4A1 ST3GAL5 ST8SIA1 TPM1 VWCE ZNF365

wild type P. gingivalis strain K1A

upregulated ACAN ACTA2 ADAMTS4 ADORA2A AGT ANGPT2 ANKRD1 ARID5A ATP10A C1QTNF5 CCL2 CEMIP CNN1 COL5A3 COX4I2 CSRP2 CTGF CX3CL1 CXCL8 DACT1 DBNDD2 DGKI DSP ELN FGF1 FRY GADD45B GBP1 GPR126 HBEGF HES1 HEYL HSPB3 HSPB7 ID3 IER3 IL21R IL32 IL6 INHBA KLF9 LBH LMCD1 MEX3B MRPL2 MSC MYH3 NEURL1B NOX4 NREP NUAK1 PAG1 PDLIM3 PITX2 PKNOX2 PMEPA1 PPAPDC1A PPFIBP2 PRR5L PTGS1 PTK2 RASL11B RCAN1 RIPK4 SCG5 SEMA5B SEPT4 SERPINE1 SOCS2 SORBS2 SOST STK38L TGFB3 TGM2 TMEM217 TRIB1 ZCCHC5 ZNF469

downregulated ABCA11P ABCA6 ABCA8 ABCC2 ABHD4 ACTB ACTBL2 ACTG2 ACTN3 ADAM19 ADAM33 ADAMTSL1 AGAP7P AGFG2 AGPAT9 AHNAK AHNAK2 AKR1C1 ALDH1A3 ALDH1B1 AMOT ANGPTL1 ANKRD11 ANKRD35 ANKRD36BP2 ANKRD37 ANO1 ANO6 ANTXR2 AOX1 APBB1IP AQP3 ARHGAP12 ARHGAP28 ARHGAP6 ARHGEF17 ARHGEF3 ARMC9 ARRDC3 ASIC1 ASPH ATF3 ATP1A4 AURKA AVEN BDKRB1 BDKRB2 BEX1 BHLHE40 BMF BMP4 BNC2 C10orf10 C10orf54 C14orf132 C15orf39 C16orf45 C18orf54 C1orf110 C1orf198 C21orf88 C3orf52 C5 C7orf69 CA12 CACNA1G CALD1 CAMKK1 CASC15 CASP1 CAT CBLN2 CC2D2A CCBE1 CCK CCL1 CCL11 CCNG1 CCNYL1 CD34 CD3EAP CD82 CD86 CDC42EP4 CDCA2 CDH18 CDO1 CDON CENPF CEP68 CFAP45 CHEK2 CHST15 CHST7 CHSY1 CISH CIT CITED4 CLCA2 CLDN14 CLEC3B CNIH3 CNNM2 COL14A1 COL6A6 COLEC12 CORO2B CRHBP CROT CSGALNACT1 CTHRC1 CWC22 CXCL1 CXCL2 CYBRD1 CYFIP2 CYP2S1 CYP3A5 CYP3A7 CYR61 DAW1 DBP DCLK2 DDAH1 DDIT4L DDR2 DDX17 DENND2A DHRS13 DIRAS1 DIRAS3 DNAJC28 DOCK4 DPT DPYD DPYSL2 DST DUSP18 DUSP6 DYNC2H1 ECE2 ECEL1 EDIL3 EGR3 EHBP1 ELMSAN1 EPB41L3 ERAP2 ETS2 ETV1 EVI2A FABP5 FAM101B FAM129A FAM167A FAM171B FAM20A FARP1 FAXDC2 FBLIM1 FGD4 FGF13 FMNL2 FMOD FNDC5 FOXQ1 FRMD4A FUS FUT8 FUT8-AS1 FZD4 G0S2 GALM GALNT12 GALNT15 GALR2 GBP2 GCHFR GDF10 GDF6 GEM GEN1 GOLGA8EP GPATCH4 GPC6 GPER1 GPR68 GREM1 GSTA2 GYS1 HAS2 HEXIM2 HEY1 HEY2 HILS1 HIST1H1D HIST1H4F HIST1H4I HIST1H4J HIST1H4K HIST2H4B HIVEP1 HMGA1 HS3ST1 HS3ST3A1 HSPA12B ICAM1 IFI44 IFIH1 IFIT1 IFIT2 IL16 IL17B IL18R1 IL1B IL20RB IL33 IL7 ILDR1 INPP5A IRF4 IRX3 ISG20 ISYNA1 ITGB1BP2 ITPKB ITPR3 IVNS1ABP JAG1 JMJD6 JUNB KAZN KCNB1 KCNK6 KCNMA1 KDSR KIAA1551 KIF13B KLF4 KLHDC9 KLHL1 KRT18 KRT18P55 KRT80 LARP1B LATS1 LECT2 LETM1 LGALS3 LIMK2 LINC00312 LINC00341 LOC100131564 LOC148709 LOC646976 LOC81691 LONRF2 LOXL3 LPPR4 LRIG3 LRRC15 LRRC32 LRRC59 LRRC75A LRRC8C LRRTM2 LTV1 LZTS3 MAFK MAN1C1 MAP2K3 MAP3K7CL MASP1 MCAM MEDAG MEF2C METTL7A MGP MICALCL MIR4697HG MITF MLXIP MME MPP1 MRGPRF MRPS6 MT1A MT1B MT1E MT1L MT1M MT2A MTFP1 MTNR1B MTUS1 MXRA5 MYBL1 MYL2 MYLK MYLK2 MYRIP NCKAP5 NCOR1 NCOR1P1 NDRG4 NEDD9 NET1 NOD1 NOTCH1 NOTCH2NL NOTCH4 NPPB NPTX1 NPY NR0B1 NT5E NTF3 NTN4 NTSR1 NYNRIN ODF3L2 OLFM1 OLFM2 OLFML1 OLFML2B OMD ORAI3 OSR2 P4HA3 PABPC4L PAK3 PAMR1 PCGF5 PCYOX1 PDGFA PDGFRL PDK4 PDLIM5 PDLIM7 PDZRN3 PER3 PF4 PGM3 PHLDA1 PHLDA2 PHLDB1 PHTF2 PLAU PLEKHA6 PLEKHG2 PLEKHG4 PLXDC1 PODNL1 POM121L9P POTEKP PPIF PPL PPP1R13L PPP1R3B PREX1 PRKCE PRPS1 PRPS1L1 PRRT2 PRRT3 PRSS3 PSG8 PTGER4 PTHLH PTPLA PTPRR PTTG1IP PVR PXDC1 PYCR1 PYROXD2 RAB33A RAB3B RAD51 RAI14 RASGRP1 RASSF5 RBM43 RBMY2EP RGS17 RGS3 RHBDF2 RIBC1 RIN3 RMI2 RNF122 RNF152 ROBO4 RPS6KA5 RRAD RRP9 RTP4 RUNX1 S100A3 S1PR1 S1PR5 SALL2 SAMD4A SCARA5 SCHIP1 SCN8A SECTM1 SELENBP1 SEMA3C SERPINB2 SESN3 SGCA SGK1 SIGLEC17P SKIL SLC14A1 SLC19A2 SLC1A2 SLC25A32 SLC29A1 SLC2A9 SLC30A3 SLC6A15 SLC6A4 SLC6A6 SLC7A14 SLC7A8 SLC9A9 SLCO4A1 SMAD7 SMARCA2 SMARCD3 SMCO4 SMIM3 SMTN SNAI1 SNHG15 SNX25 SNX29P1 SOCS1 SOX4 SOX8 SOX9 SPOCD1 SPRED2 SPTLC2 SPTLC3 SQLE SSH1 ST3GAL5 ST8SIA1 STAC STBD1 SVIL SYNE3 SYNGR3 SYT1 SYT12 TAGLN TBC1D2B TENM4 TFPI2 TGFB1 TGFBR2 TGFBR3 THBD THSD1 TMED9 TMEM100 TMEM106B TMEM132B TMEM133 TMEM158 TMEM159 TNFAIP3 TNFRSF21 TNFSF13B TNFSF4 TNXB TPM1 TPM2 TPST2 TPX2 TRAF5 TRERF1 TRIM59 TRIM6 TRIO TSHZ1 TSPAN14 TUBB2A TUBB6 TXLNB TXNIP TYMSOS TYR UBE2E3 UNC5B UPP1 VASN VDR VEPH1 VWA5A VWCE WISP2 WLS XRCC6BP1 YRDC ZFAND5 ZNF300P1 ZNF395 ZNF608

wild type P. gingivalis strain DPG3

upregulated ACAN ACTA2 ACTG2 ADAM19 ADAMTS14 ADAMTS4 ADORA2A ADORA2B AGT ANGPT2 ANKRD1 APBB1IP APOC1 ARID5A ATP10A AZIN2 BAALC BHLHE40 C15orf39 C1QTNF5 C7orf69 CACNA1D CASC15 CBLN2 CCDC102B CCL1 CCL11 CCL2 CCNYL1 CD3EAP CDKN2B CDX1 CENPVP1 CHSY3 CLDN14 CLDN8 CMKLR1 CNN1 CNNM2 COL21A1 COL27A1 COL4A1 COL5A3 COX4I2 CRHBP CRISPLD2 CSRP2 CTAGE10P CTGF CTHRC1 CX3CL1 CXCL1 CXCL2 DAAM2 DACT1 DAND5 DBNDD2 DCLK2 DEPTOR DGKI DPT DSP ECE2 EDNRA EIF4EBP1 ELN ENC1 ETS1 FGF1 FHL3 FMOD FRY G0S2 GADD45B GBP1 GEM GEN1 GGTA1P GPR126 GSTA2 GUCY1A3 GUCY1B3 H19 HBEGF HES1 HES5 HEY1 HEY2 HEYL HILS1 HSPA2 HTRA3 IER3 IL17B IL18R1 IL1B IL21R IL33 IL6 INHBA ISG20 ISYNA1 ITGA11 IVNS1ABP JAG1 JUNB KCNG1 KIAA1755 KLF10 KLF9 KRT18 KRT18P55 LECT2 LIMK2 LINC00312 LMCD1 LOC100130815 LOC441178 LOXL3 LPPR4 LRRC32 MAFK MCAM MEX3B MLXIP MSC MTHFD2 MYLK2 NEDD9 NEURL1B NGFR NOD1 NOTCH1 NOTCH4 NOX4 NPPC NREP NTN4 NUAK1 OLFM2 OLFML2A OLFML2B P4HA3 PAG1 PCSK1 PDGFA PDLIM3 PF4 PHLDA2 PHLDB1 PITX2 PKNOX2 PLEKHG2 PLXDC1 PMEPA1 POM121L9P PPAPDC1A PPFIBP2 PPP1R13L PPP1R3B PRR4 PRR5L PTGS1 PTK2 PYCR1 RAI14 RASD1 RASL11B RIPK4 RNF122 RNF152 RUNX1 S100A3 S1PR5 SAMD5 SEL1L SEMA5B SEPT4 SERPINE1 SGCA SGK1 SH3PXD2A SIK1 SLC10A1 SLC16A12 SLC19A2 SLC1A4 SLC29A1 SLC30A3 SLC7A5 SNAI1 SNAI2 SORBS2 SOX4 SPDL1 SPOCD1 SPON2 SPP1 SSH1 ST3GAL2 TBX2 TDO2 TGFB1 TGFB3 TGM2 TMC4 TMEM133 TMEM156 TMEM217 TNFAIP6 TNFSF4 TPM1 TPX2 TRIB1 TTYH2 UCK2 UNC5B USP31 VDR VIP VLDLR VSTM4 WISP1 XAF1 XRCC4 YRDC ZCCHC5 ZNF423 ZNF469

downregulated AADAT ABCA3 ABCA4 ABCA6 ABCA8 ABCC2 ABCC3 ABLIM3 ACAT1 ACBD4 ACCS ACKR4 ACOX2 ACSF2 ACTB ACTBL2 ACTG1 ACTN1 ACTN3 ACTR3 ACYP1 ADA ADAM33 ADAMTS1 ADAMTSL1 ADCK3 ADCY4 ADD3 ADH1A ADH1C ADHFE1 ADM ADRB2 ADSSL1 AGBL2 AGFG2 AGPAT9 AHNAK AHNAK2 AKAP13 AKR1B10 AKR1C1 AKT3 ALDH1A1 ALDH1A3 ALDH1B1 ALDH6A1 ALOX12P2 ALPK2 AMOT AMOTL1 AMPD3 AMT ANGPT1 ANGPTL1 ANK3 ANKFY1 ANKRD13A ANKRD35 ANKRD37 ANO3 ANO6 ANPEP ANTXR2 ANXA10 AOC3 AOX1 AP1G2 AP3M2 APC2 APOBEC3C APOBEC3F APOBEC3G AQP1 AQP3 ARF4 ARHGAP12 ARHGAP18 ARHGEF17 ARHGEF3 ARHGEF7 ARL5B ARL6IP5 ARPP21 ARRDC3 ARRDC4 ARSI ART4 ASIC1 ASNS ASPA ASPG ASTN2 ATF3 ATHL1 ATOH8 ATP6AP1L ATP6V0E2 ATP9A ATXN1 AUH AVEN AVPI1 AXIN2 AXL B3GALT4 B3GNT1 B3GNT2 B4GALT3 BAHCC1 BATF2 BCKDHB BCL7A BCL9L BCR BDKRB1 BDKRB2 BDNF BEND6 BEX1 BGN BIVM BMF BMP4 BNC1 BNC2 BPGM BRD4 BTBD9 BTN2A2 BTN3A1 BTN3A2 BYSL C10orf2 C10orf54 C10orf90 C11orf24 C11orf54 C11orf84 C14orf132 C14orf159 C16orf45 C16orf74 C1orf167 C1orf21 C1orf213 C1orf56 C20orf57 C3orf18 C5 C6orf1 C8orf48 CA11 CA12 CA5B CABLES1 CACNA1G CACNG6 CALD1 CAMK2B CAMK2G CAMKK1 CAPS2 CARD10 CARD6 CASP1 CAT CAV1 CAV2 CAV3 CBR3 CBX7 CC2D2A CCBE1 CCBL1 CCDC115 CCDC121 CCDC125 CCDC25 CCDC81 CCDC85B CCDC88B CCIN CCK CCNE1 CCNG1 CCRN4L CD109 CD200 CD302 CD34 CD52 CD82 CD9 CDC14C CDC42EP4 CDCA2 CDCP1 CDH1 CDH18 CDNF CDON CDR2L CDRT1 CECR5-AS1 CELA2A CEMIP CENPF CENPN CEP250 CEP70 CFAP70 CGNL1 CH25H CHEK2 CHI3L1 CHRNB1 CHST15 CHST6 CHST7 CHSY1 CIART CILP CISH CIT CITED2 CITED4 CKAP2 CLCA2 CLEC3B CLMP CNIH3 CNN3 CNTN3 COL13A1 COL14A1 COL18A1 COL4A2 COL5A2 COL6A6 COL8A2 COLEC12 CORO6 CPA4 CPAMD8 CPED1 CREB3L4 CREBRF CREG2 CRYL1 CRYM CSGALNACT1 CSRNP1 CTH CTPS1 CTSK CTSL CUX1 CXCL6 CYB561A3 CYB5A CYBRD1 CYCS CYFIP2 CYP1A1 CYP2S1 CYP3A5 CYP3A7 CYP4X1 CYR61 DAB2IP DAG1 DBP DCBLD2 DDAH1 DDB2 DDIT4 DDIT4L DDX60 DENND1A DENND3 DGCR8 DHFRL1 DHRS1 DHRS13 DHRS3 DHX58 DICER1-AS1 DIO2 DIRAS3 DISC1 DISP1 DKC1 DLC1 DLG1 DNMBP DOCK11 DOCK4 DOK1 DOK5 DPF3 DPH2 DPYD DPYSL2 DPYSL4 DRAM1 DSE DSEL DSTN DTWD2 DUSP6 DYNC1LI1 DYNC2H1 DZIP1L E2F3 EBF2 EBF3 ECH1 ECHDC2 ECI2 EDIL3 EDN1 EFCAB6 EFNB1 EGR3 EHBP1 EHD3 ELL3 EMCN EMX2OS EN1 ENO2 ENOX1 ENTPD7 EPAS1 EPB41L1 EPB41L3 EPHA5 ERAP2 ERRFI1 ETNK2 ETS2 ETV1 ETV4 EVI2A EVI2B EVL EYA2 F10 FAM101B FAM102B FAM109B FAM111A FAM117A FAM129A FAM149A FAM162A FAM167A FAM180A FAM20A FAM217B FAM26E FAM27C FAM60A FARP1 FAT1 FAXDC2 FBLIM1 FBLN5 FBXL14 FBXL16 FBXO30 FERMT1 FES FGD4 FGF13 FGF16 FGF7 FGFR1 FGFR3 FHOD1 FIG4 FIGF FKBP1A FLOT2 FMNL2 FOSL2 FOXF1 FOXG1 FOXK1 FOXO1 FOXQ1 FOXRED2 FRK FRMD4A FRMD5 FRMD6 FUK FUS FUT8 FUT8-AS1 FUZ FYCO1 FZD1 FZD4 FZD8 GABPB1 GADD45A GALM GALNT11 GALNT12 GALNT15 GALNT5 GALT GAMT GAS1 GBP2 GCHFR GDF10 GDF5 GFOD1 GIF GJA4 GLI2 GLIPR1L2 GLIPR2 GLIS1 GLIS3 GLRX GM2A GMPR GNG11 GNG2 GNPDA1 GOLT1B GPC2 GPER1 GPM6B GPNMB GPR39 GPR4 GPR56 GPR68 GPRASP1 GPRC5B GREM2 GRIK2 GRTP1 GSAP GSTM2 GSTM5 GULP1 GYPC HCN3 HDAC9 HEXIM2 HFE HHAT HIVEP1 HMGA1 HMGCS1 HMGN3 HMOX1 HNRNPAB HOXA2 HOXA3 HPS3 HS3ST1 HS6ST3 HSD11B1 HSD17B6 HSD17B8 HSPA12B HSPA4L HTR2B HTR7 HYKK ICAM2 ID1 ID2 ID3 IDH1 IDH2 IFFO1 IFI44 IFI44L IFIH1 IFIT1 IFIT2 IFNE IFNGR1 IGF2BP3 IGFBP1 IGFBP5 IL15RA IL16 IL17RC IL17RD IL1A IL1RL1 IL20RB IL32 IL34 IL7 IQCD IRF4 IRX3 ITGA2 ITGA6 ITGA7 ITGB1BP2 ITGB3 ITGB8 ITPKB ITPR3 JADE2 JARID2 JDP2 JMJD6 JPH2 KAL1 KAT2B KAZALD1 KBTBD3 KCNB1 KCNJ2 KCNK1 KCNK6 KCNMA1 KCNN4 KCNS3 KCTD15 KDELR2 KIAA0020 KIAA0101 KIAA0125 KIAA0247 KIAA0513 KIAA1217 KIAA1522 KIAA1551 KIAA1683 KIF11 KIF13B KLF4 KLF7 KLHDC9 KLHL13 KLHL41 KRT19 KRT32 KRT80 L3HYPDH LAMB1 LAMC2 LARP1B LBH LDB2 LEF1 LELP1 LGALS3 LGALS9C LGMN LGR4 LGR5 LHFPL2 LIMS1 LINC00152 LINC00341 LINC00839 LINC01003 LINC01315 LIPC LMO3 LOC100130433 LOC100132167 LOC644936 LOC646976 LOC79999 LOC81691 LONRF2 LOXL4 LPIN1 LPXN LRIG3 LRP4 LRRC15 LRRC59 LRRC75A LRRC8C LRRC8D LRRTM2 LY6E LY96 LYRM9 LZTS1 MAB21L2 MALL MAMLD1 MANBA MANSC1 MAP2K3 MAP3K12 MAPT MARCH2 MARCKSL1 MARS MASP1 MAST4 MATN3 MBP MCCC1 MED14OS MEDAG MEGF6 MEIS1 MET METTL1 METTL7A MGARP MICALCL MICALL2 MKI67 MKL1 MKL2 MLC1 MME MMP1 MMP10 MMP16 MOAP1 MPG MPL MPP1 MPP3 MRGPRF MROH8 MRPS6 MSR1 MT1A MT1B MT1E MT1L MT1M MT2A MTFP1 MTHFR MTSS1 MTUS1 MUS81 MXRA5 MYBBP1A MYC MYH9 MYL9 MYO19 MYOC MYRIP NAA40 NAB1 NACC2 NANOS1 NBEA NBEAL2 NCALD NCF2 NCKAP5 NDRG3 NDRG4 NEDD4L NEIL1 NET1 NEURL2 NFE2L3 NGEF NHLRC4 NIFK NIPAL3 NLGN1 NLGN4Y NLRC5 NLRP1 NMNAT2 NMT2 NNMT NOC2L NOP2 NOV NOXA1 NPHP1 NPTX1 NR0B1 NR2F1-AS1 NT5DC2 NT5E NTF4 NTNG2 NTSR1 NUDT6 NYNRIN OAS1 OBFC1 OCIAD2 ODF2 OLFML1 OLFML3 OLR1 OSBPL1A OSGEPL1 OSR1 OSR2 OTOS PAK3 PAMR1 PARD6A PARP14 PARP9 PASK PAWR PCDH9 PCK2 PCNXL2 PCYOX1 PDE3A PDE4B PDE4DIP PDGFC PDGFD PDGFRA PDGFRB PDGFRL PDK4 PDLIM7 PDZRN3 PECR PELI3 PER3 PERP PEX11A PGBD3 PGM3 PGPEP1 PHLDA1 PHOSPHO2 PHYH PHYHD1 PIGW PIK3R1 PIM1 PIP PKIA PLA2G16 PLA2G4C PLAT PLAU PLCD1 PLCD3 PLCD4 PLCXD1 PLD6 PLEC PLEKHA4 PLEKHA6 PLEKHG3 PLEKHG4 PLIN2 PLSCR4 PLXDC2 PNKD PNO1 PODN PODNL1 PODXL POLR3D POLR3GL POTEKP PPAP2A PPAP2B PPFIA4 PPIF PPIP5K1 PPL PPP1R14C PPRC1 PREB PREX1 PRKAB2 PRKCZ PRPS1 PRPS1L1 PRR5 PRRT2 PRRT3 PRSS2 PRSS3 PRSS35 PSAT1 PSD3 PSEN2 PSMB8 PSMG3-AS1 PTGER1 PTGER2 PTGER4 PTGIS PTH1R PTPLA PTPN2 PTX3 PUS7 PXDC1 PXN PXYLP1 PYCARD PYDC1 PYGB PYROXD2 RAB23 RAB38 RABGAP1 RALGDS RALGPS2 RAPGEF3 RAPGEF6 RARG RARRES1 RARRES3 RASAL2 RASGRP1 RASL11A RASSF2 RASSF5 RBM24 RBM43 RCAN1 RCAN2 RCL1 RDH5 REG4 RGS16 RGS17 RGS2 RGS3 RHBDF1 RHBDF2 RILP RIMBP3 RIN3 RMI2 RNASE4 RNASEL RNASET2 RNF121 RNF144A RNF144B ROBO4 ROR1 RPS6KA5 RRAD RRP9 RTKN2 RTN4RL1 RTP4 S1PR1 SACS SALL2 SAMD3 SAMD4A SAR1A SASH1 SCARA3 SCARA5 SCD5 SCG5 SCN8A SCN9A SCRN3 SDCCAG8 SEC31B SECTM1 SELENBP1 SEMA3A SEMA3B SEMA3C SEMA3D SEPT3 SEPT8 SERINC5 SERPINA3 SERPINB1 SERTAD2 SERTAD4 SESN3 SFR1 SFRP1 SGIP1 SH2D5 SH3BP5 SH3D19 SH3RF1 SHC3 SHMT2 SHQ1 SIGLEC17P SIRT4 SIX1 SKIL SLC13A4 SLC14A1 SLC15A4 SLC16A14 SLC18B1 SLC1A1 SLC1A2 SLC20A1 SLC22A15 SLC23A2 SLC24A3 SLC25A13 SLC25A27 SLC25A29 SLC25A32 SLC26A11 SLC26A4 SLC27A1 SLC27A3 SLC2A9 SLC38A4 SLC39A8 SLC3A2 SLC40A1 SLC43A3 SLC47A2 SLC48A1 SLC6A15 SLC6A4 SLC6A6 SLC7A1 SLC7A14 SLC7A4 SLC7A6 SLC7A8 SLC9A3R2 SLC9A9 SLCO2A1 SLCO4A1 SLITRK6 SLX1A SLX4IP SMAD3 SMAD5-AS1 SMAD7 SMAD9 SMC6 SMCO4 SMIM3 SMTN SNHG15 SNX2 SNX21 SNX25 SNX29P1 SOCS2 SOCS3 SOX17 SOX8 SPARCL1 SPC24 SPRED2 SPRY1 SPRY2 SPTBN4 SPTLC3 SRA1 SRF SRM SRPX SRSF3 SSPN SSTR1 ST3GAL5 ST3GAL6 ST8SIA1 STAC STARD13 STARD4 STAT1 STAU2 STBD1 STC1 STC2 STEAP2 STEAP3 STK38L STMN3 STXBP6 SULF2 SUN1 SVEP1 SVIL SYNGR1 SYNPO2 SYT1 SYT11 TAGLN TANC1 TBC1D22B TBC1D2B TCAIM TCEA3 TCF7 TCP11L2 TEAD2 TEF TEKT2 TENM4 TES TEX19 TFAP2D TFPI TFPI2 TGFBI TGFBR2 TGFBR3 THAP8 THBD THBS1 THSD1 THUMPD2 TIMP3 TIMP4 TIPARP TLR1 TLR3 TM4SF1 TM7SF2 TM7SF3 TMC6 TMEFF2 TMEM100 TMEM106B TMEM106C TMEM11 TMEM130 TMEM132B TMEM140 TMEM158 TMEM159 TMEM171 TMEM180 TMEM2 TMEM200A TMEM208 TMEM25 TMEM38A TMEM55A TMPO TMTC1 TMX4 TNFAIP2 TNFAIP8L3 TNFRSF11B TNFRSF14 TNFRSF21 TNFSF12 TNFSF13B TNNC2 TNS3 TNXB TOB1 TOMM40 TOR4A TOX2 TP53 TPK1 TPST2 TRAF5 TRERF1 TRIB3 TRIM2 TRIM37 TRIM5 TRIM59 TRIM6 TRIM8 TRIOBP TSHZ1 TSPAN14 TSPAN4 TSPAN8 TUBB2A TUBB6 TUFT1 TXLNB TXNIP TYMSOS UBA7 UBALD1 UBE2E3 UBE2L6 UNC13B UPB1 UPK3B UPP1 URB2 USP53 VAMP5 VASN VASP VAT1L VEPH1 VIT VNN2 VPS13A VWA5A VWCE WBSCR27 WDR4 WDR54 WEE2-AS1 WFS1 WISP2 WLS WNT3 WNT5B WWC1 WWTR1 XBP1 XG XPC XRCC6BP1 XYLT1 ZBED4 ZDHHC12 ZEB2 ZFAND5 ZFHX2 ZFHX4 ZFP14 ZFP36 ZFP69B ZHX3 ZMYND15 ZNF175 ZNF207 ZNF22 ZNF286A ZNF395 ZNF438 ZNF540 ZNF608 ZNF697 ZNF850 ZSCAN16

wild type P. gingivalis strain KRX718

upregulated ACTA2 ADAM19 ADAMTS14 ADAMTS4 ADORA2A ADORA2B AGT ALDH1A1 ALPK2 ANGPT2 ANKRD1 APBB1IP APOC1 ARID5A ATP10A ATP6AP1L BAALC BHLHE40 C15orf39 C1QTNF5 C7orf69 CA4 CASC15 CBLN2 CCDC102B CCL1 CCL11 CCL2 CCNYL1 CDKN2B CGNL1 CHSY3 CLDN14 CMKLR1 CNN1 COL21A1 COL27A1 COL4A1 COL5A3 COX4I2 CRHBP CRISPLD2 CSRP2 CTGF CTHRC1 CX3CL1 CXCL1 CXCL2 DAAM2 DACT1 DAND5 DBNDD2 DCLK2 DEPTOR DPT DSP ECE2 EDNRA ELN ENC1 ETS1 FGF1 FGFR3 FMOD FRY G0S2 GADD45A GADD45B GBP1 GEN1 GGTA1P GJA4 GPR126 GSTA2 GUCY1A3 GUCY1B3 H19 HBEGF HES1 HES5 HEY1 HEY2 HEYL HILS1 HSPA2 HTRA3 IER3 IL15RA IL17B IL18R1 IL1B IL21R IL33 IL6 INHBA ISG20 ISYNA1 JAG1 JUNB KLF10 KLF9 KRT18 KRT18P55 LECT2 LIMK2 LINC00312 LMCD1 LOC441178 LOXL3 LPPR4 LRRC32 MAFK MBP MCAM MEX3B MLXIP MSC MTHFD2 MYLK2 NCALD NEURL1B NGFR NOD1 NOTCH1 NOTCH4 NOX4 NPPC NREP NTN4 NUAK1 OLFM2 OLFML2B PAG1 PCSK1 PDGFA PDLIM3 PF4 PHLDA2 PHLDB1 PITX2 PKNOX2 PLEKHG2 PLXDC1 PMEPA1 POM121L9P PPAPDC1A PPFIBP2 PPP1R3B PRR5L PTK2 RAI14 RASD1 RASL11B RIN3 RIPK4 RNF122 RNF152 ROR1 S100A3 S1PR5 SAMD5 SASH1 SEMA3G SEMA5B SEPT3 SEPT4 SERPINE1 SGCA SGK1 SH2D5 SLC16A12 SLC1A4 SLC29A1 SLC30A3 SLC7A5 SNAI2 SORBS2 SOX4 SPDL1 SPON2 SPP1 SSH1 ST3GAL2 TBX2 TDO2 TGFB1 TGFB3 TMC4 TMC6 TMEM133 TMEM217 TNFSF4 TPM1 TPX2 TRIB1 TTYH2 UNC5B VLDLR VSTM4 YRDC ZCCHC5 ZNF423 ZNF469

downregulated ABCA3 ABCA4 ABCA6 ABCA8 ABCC2 ABCC3 ABLIM3 ACAN ACAT1 ACCS ACKR4 ACTB ACTBL2 ACTG2 ACTN1 ACTN3 ACYP1 ADA ADAM33 ADAMTS1 ADAMTSL1 ADCY4 ADD3 ADH1A ADM AGBL2 AGFG2 AGPAT9 AHNAK2 AKAP13 AKR1B10 AKR1C1 ALDH1A3 ALDH3A1 ALDH6A1 AMD1 AMOT AMPD3 ANGPT1 ANKFY1 ANKH ANKRD13A ANKRD35 ANO6 ANPEP ANTXR2 ANXA10 AOC3 AOX1 AP3M2 APOBEC3F APOBEC3G AQP1 AQP3 ARHGAP12 ARHGAP18 ARHGEF17 ARHGEF3 ARHGEF7 ARHGEF9 ARL5B ARL6IP5 ARPP21 ARRDC3 ARRDC4 ARSI ART4 ASIC1 ASNS ASPA ASPM ATF3 ATHL1 ATOH8 ATP6V0E2 ATXN1 AVEN AVPI1 AZIN2 B3GNT1 B4GALT3 BAHCC1 BATF2 BDKRB1 BDKRB2 BDNF BGN BMP4 BNC1 BNC2 BPGM BTN2A2 BYSL C10orf54 C11orf54 C14orf132 C16orf45 C16orf74 C1orf167 C1orf21 C3orf18 C3orf52 C5 C6orf1 CA11 CA12 CA5B CABLES1 CACNA1G CACNG6 CALD1 CAMK2B CAMK2G CAMKK1 CAPS2 CARD6 CASP1 CAT CAV1 CAV2 CAV3 CBR3 CBX7 CC2D2A CCBE1 CCDC125 CCDC85B CCDC88B CCK CCL7 CCNG1 CCRN4L CD200 CD34 CD3EAP CD82 CD9 CDCA2 CDCP1 CDH18 CDON CDR2L CDX1 CECR5-AS1 CELA2B CEMIP CENPF CENPN CH25H CHEK2 CHI3L1 CHST15 CHST2 CHST7 CHSY1 CISH CIT CITED2 CITED4 CKAP2 CLCA2 CLEC3B CLMP CNIH3 CNN3 CNNM2 COL13A1 COL14A1 COL18A1 COL4A2 COL5A2 COL6A6 COL8A2 COLEC12 COPG1 CORO6 CPA4 CPAMD8 CPED1 CPPED1 CREBRF CREG2 CSGALNACT1 CSRNP1 CTH CTSL CXCL3 CXCL6 CYBRD1 CYCS CYFIP2 CYP1A1 CYP2S1 CYP3A5 CYP3A7 CYP4X1 CYR61 DAB2IP DBP DDAH1 DDIT4 DDIT4L DENND1A DGKI DHRS1 DHRS13 DHRS3 DIO2 DIRAS3 DISP1 DLC1 DLG1 DNMBP DOCK4 DOK1 DOK5 DPF3 DPH2 DPYD DPYSL2 DRAM1 DSE DTWD2 DUSP6 DYNC1LI1 DYNC2H1 EBF1 EBF2 EBF3 EDIL3 EDN1 EFNB1 EGR1 EGR3 EHBP1 EHD3 EIF4EBP1 EMCN EN1 ENOX1 ENTPD7 EPAS1 EPB41L3 ERAP2 ETS2 ETV1 EVI2A EVI2B EVL EYA2 FAM101B FAM109B FAM111A FAM124A FAM129A FAM180A FAM20A FAM26E FAM27C FAM27E2 FAM60A FARP1 FAT1 FAXDC2 FERMT1 FES FGD4 FGF13 FGF16 FGF7 FGFR1 FHAD1 FHL3 FHOD1 FLOT2 FMNL2 FOSL2 FOXF1 FOXG1 FOXK1 FOXO1 FOXQ1 FRK FRMD5 FRMD6 FUS FUT8 FUT8-AS1 FUZ FYCO1 FZD1 FZD4 FZD7 FZD8 G6PD GABPB1 GALM GALNT12 GALNT15 GAMT GBP2 GCHFR GDF10 GEM GFOD1 GLI2 GLIS1 GLIS3 GLRX GM2A GMPR GNG2 GNPDA1 GPC2 GPER1 GPM6B GPNMB GPR39 GPR56 GPR68 GPRASP1 GPRC5B GREM2 GRIK2 GSAP GSTM5 GUCY2F GULP1 GYPC HEXIM2 HHAT HIP1R HIST1H1D HIST1H4F HIVEP1 HMGA1 HMGCS1 HMOX1 HNRNPAB HNRNPDL HOXA2 HRCT1 HS3ST1 HS6ST3 HSD11B1 HSD17B6 HSD17B8 HSPA12B HSPA4L HTR2B HTR7 ICAM2 ID2 ID3 IDH1 IFFO1 IFI44 IFI44L IFIH1 IFIT1 IFIT2 IFNGR1 IGF1 IGF2 IGF2BP3 IGFBP1 IGFBP5 IL12A IL16 IL17RC IL17RD IL1A IL1RL1 IL20RB IL34 IL7 ING5 IQCD IRF4 ITGA11 ITGA2 ITGA6 ITGA7 ITGB3 ITGB8 ITPKB ITPR3 IVNS1ABP JADE2 JMJD6 KANK1 KAT2B KAZALD1 KAZN KBTBD3 KCNB1 KCNG1 KCNJ2 KCNJ4 KCNK1 KCNMA1 KCNN4 KCNS3 KCTD15 KCTD4 KIAA0020 KIAA0101 KIAA0247 KIAA0513 KIAA1217 KIAA1551 KIAA1683 KIAA1755 KIF13B KLF4 KLF7 KLHDC9 KLHL13 KPNA2 KRT19 KRT32 L3HYPDH LAMA2 LAMB1 LAMC2 LAPTM4A LBH LCN6 LDB2 LEF1 LELP1 LGALS3 LGALS9C LGMN LGR4 LHFPL2 LIF LIMS1 LINC00152 LINC00341 LINC00597 LINC00839 LINC01003 LINC01315 LIPC LMO3 LOC646976 LOC730101 LOC81691 LONRF2 LOXL4 LPIN1 LPXN LRP4 LRRC59 LRRC75A LRRC8C LRRC8D LRRN3 LRRTM2 LY6E LY96 LZTS1 MAB21L2 MALL MAMLD1 MANBA MANSC1 MAP2K3 MARCH2 MARCKSL1 MASP1 MED14OS MEDAG MEGF6 MET METTL1 METTL7A MFI2 MGARP MICALCL MICALL2 MKL2 MMP1 MOAP1 MPP1 MPP3 MRAP2 MRGPRF MRPS6 MSR1 MT1A MT1B MT1E MT1L MT1M MT2A MTFP1 MTHFR MTSS1 MXRA5 MYBBP1A MYC MYL2 MYO19 MYOC MYRIP NAA40 NAB1 NACC2 NANOS1 NCKAP5 NCOR1P1 NDRG3 NDRG4 NEDD4L NEDD9 NET1 NFE2L3 NGEF NHLRC4 NHS NKD2 NLGN1 NLRP1 NMNAT2 NMT2 NOXA1 NPTX1 NR0B1 NR2F1-AS1 NT5E NTN1 NTNG2 NTSR1 NXT2 NYNRIN OBFC1 OCIAD2 ODF2 OLA1 OLFML1 OLFML2A OSR1 OSR2 P2RY14 P4HA3 PAK3 PAMR1 PARP14 PARP9 PCK2 PCNXL2 PCYOX1 PDE1C PDE3A PDE4DIP PDGFC PDGFD PDGFRB PDK4 PDLIM7 PDZRN3 PER3 PERP PEX11A PGBD3 PGM3 PGPEP1 PHLDA1 PHOSPHO2 PIK3R1 PIM1 PKIA PLA2G16 PLA2G4C PLAT PLAU PLCD3 PLCXD3 PLD6 PLEKHA4 PLEKHA6 PLEKHG3 PLIN2 PLSCR4 PNKD PNO1 PODN PODXL POLR3D PPAP2A PPIF PPL PPP1R13L PPRC1 PREB PREX1 PRKAB2 PRR5 PRRT2 PRRT3 PRSS1 PRSS2 PRSS3 PRSS35 PSAT1 PSD3 PSEN2 PTGER2 PTGIS PTGS1 PTH1R PTTG1IP PTX3 PUS7 PXDC1 PXN PYCARD PYCR1 PYDC1 PYROXD2 RAB23 RALGPS2 RAMP1 RANBP17 RARRES1 RARRES3 RASAL2 RASGRP1 RASL11A RASSF5 RBM24 RBM43 RCAN1 RCAN2 RDH5 REEP2 RFC2 RFPL2 RGS17 RGS2 RGS3 RHBDF2 RILP RIMBP3 RMI2 RNASE4 RNASET2 RNF144A ROBO4 RPS6KA5 RRAD RRP9 RTKN2 RTP4 RUNX1 S1PR1 SACS SALL2 SAMD3 SAR1A SCARA3 SCARA5 SCD5 SDC4 SDCCAG8 SECTM1 SELENBP1 SEMA3A SEMA3B SEMA3C SEMA3D SEPT8 SERINC5 SERPINA3 SERPINB1 SERPINI2 SERTAD2 SERTAD4 SESN3 SFR1 SGIP1 SH3BP5 SH3D19 SH3PXD2A SH3RF1 SHC3 SHMT2 SHQ1 SIGLEC17P SIK1 SIX1 SIX2 SKIL SLC13A4 SLC14A1 SLC18B1 SLC19A2 SLC1A1 SLC1A2 SLC20A1 SLC22A15 SLC24A3 SLC25A13 SLC25A25 SLC25A29 SLC25A32 SLC25A41 SLC27A1 SLC27A3 SLC2A2 SLC2A9 SLC38A4 SLC39A8 SLC3A2 SLC48A1 SLC5A6 SLC6A15 SLC6A4 SLC6A6 SLC7A1 SLC7A14 SLC7A4 SLC7A6 SLC7A8 SLC9A3R2 SLC9A9 SLCO4A1 SLITRK6 SLX1A SMAD3 SMAD7 SMARCA2 SMC6 SMCO4 SMG1P1 SMIM3 SMTN SNAI1 SNHG15 SNTB1 SNX25 SOCS2 SOCS3 SOX17 SOX8 SPARCL1 SPOCD1 SPRED2 SPRY2 SPTLC3 SRF SRPX SRSF3 SSPN SSTR1 ST14 ST3GAL5 ST3GAL6 STAC STARD13 STARD4 STAT1 STBD1 STC1 STC2 STEAP2 STEAP3 SULF2 SUN1 SVEP1 SVIL SYNE3 SYT1 SYT11 SYT12 TAGLN TANC1 TBC1D22B TBC1D2B TCAIM TCEA3 TCF7 TCP11L2 TEAD2 TEKT2 TENM4 TFAP2D TFPI TFPI2 TGFBI TGFBR2 TGFBR3 TGM2 THBD THBS1 THSD1 TIMP3 TIMP4 TLR1 TM7SF2 TM7SF3 TMEFF2 TMEM106B TMEM106C TMEM11 TMEM130 TMEM132B TMEM140 TMEM158 TMEM159 TMEM171 TMEM200A TMEM25 TMEM35 TMEM38A TMTC1 TMTC2 TMX4 TNFAIP2 TNFAIP3 TNFAIP6 TNFAIP8L3 TNFRSF11B TNFRSF14 TNFRSF21 TNFSF12 TNFSF13B TNNC2 TNS3 TNXB TOB1 TOMM40 TOR4A TOX2 TPK1 TPST2 TRAF5 TRAM2 TRERF1 TRIB3 TRIM2 TRIM37 TRIM5 TRIM59 TRIM6 TRIM8 TRIOBP TSPAN4 TSPAN8 TUBB2A TUBB6 TXLNB TXNIP TYMSOS UBE2L6 UBE3D UBXN2B UCK2 UNC13B UPB1 UPK1A UPP1 USP31 USP53 VASN VDR VEPH1 VIT VWA5A VWCE WBSCR27 WDR4 WEE2-AS1 WISP1 WISP2 WLS WWC1 WWTR1 XAF1 XBP1 XG XRCC4 XRCC6BP1 XYLT1 YPEL2 ZBED4 ZEB2 ZFAND5 ZFHX2 ZFP36 ZMYND15 ZNF395 ZNF608 ZNF702P ZNF850

Transcriptional Profiling of Bone Marrow Stromal Cells in Response to Porphyromonas gingivalis Secreted Products Reddi1 and Belibasakis, 2012

Genes up-regulated more than two-fold at 6 h ACSS2 ADD3 AGRN ALDH4A1 ANKRD47 APOL9B ARHGEF3 ARNTL ARRB2 ASL ATP6V0B ATP6V1A AXUD1 BC004044 BC046404 BCKDHB BEX2 BRP17 C630004H02RIK CAPN5 CASP4 CBARA1 CCDC92 CCL17 CCL2 CCL3 CCL5 CCL7 CCL9 CCRN4L CD248 CD44 CD74 CDK2AP2 CDKN1A CDKN2A CEBPB CH25H CHAC1 CHST8 CKB CMBL COL18A1 COX7A1 CRIP2 CSDC2 CSF1 CSF2 CTSL CX3CL1 CXCL1 CXCL10 CXCL2 CXCL9 DCXR DDIT4 DHCR7 DOK4 DOS EFNA3 EGLN3 EGR2 EHD3 EIF4E3 ENO2 FAS FBXO31 FKBP5 GBP2 GCA GCH1 GCHFR GCNT2 GDF15 GDPD5 GNB5 GPRC5A GRTP1 H1F0 H2-DMA H2-M3 HAGH HAP1 HEY1 HIF1A HOOK2 HP HR HRB HRBL HS2ST1 HSD17B7 ID1 IDI1 IER3 IFI30 IFI47 IGSF3 IGSF9 INSL6 IRF1 ITPKA JUNB KANK3 KIF5C LCN2 LIMK1 LMCD1 LOC100043986 LOC100044177 LOC100045343 LOC100046457 LOC100047651 LOC100048436 LRIG1 LRRC15 MAP3K8 MAPK8IP1 MAPKAPK3 METRN MFAP3L MFSD7 MICALL2 MMP13 MMP17 MTAP MYCL1 NAB1 NAPA NCALD NEU1 NFKBIA NFKBIE NFKBIZ P4HA2 PBX4 PCYT2 PDXP PFKP PHLDA1 PLK2 PLSCR1 PLVAP PLXDC1 POR PRKCD PRSS35 PSMB8 PTGES PTGS2 PTPN1 PTX3 RAB3A RAB3D RAB3IL1 RAB3IP RAC3 RASL11B RASL12 RBM38 REEP6 REM2 RIPK2 RPO2TC1 SAA3 SC4MOL SEMA6B SERPINA3F SERPINA3G SIAT9 SKIL SLC11A2 SLC24A6 SLC25A33 SLC2A6 SLC45A4 SLC9A3R1 SLPI SMOX SNAPC1 SNX18 SOCS3 SOD2 SPSB1 SQLE ST3GAL5 STAC2 STAT3 STX6 SYN1 SYNGR3 SYT13 TAPBP TEC TGOLN1 TLR-2 TMEM25 TMEM50B TMEM66 TMOD1 TNFAIP2 TNFAIP3 TNIP1 TNNC1 TSC22D1 TTLL1 TUBB2B UBD USP2 VEGF WFDC3 XPR1 ZC3H12A

Downregulated at 6 hrs ACCS ACP2 ACSF3 ACY3 ADAM12 AP4M1 AP4S1 ARSJ AURKA AVEN AVPR1A AVPR1A AW061290 BC029169 BC039093 BC067068 BMP4 BRD9 BRD9 C87436 C87436 CC2D2A CCDC91 CDC20 CDC20 CDKN2C CENPA CLDN15 CUL1 CUL7 D030070L09RIK D030070L09RIK D14ERTD449E DBP DIS3L EFNA5 EIF5 ELA1 ELF1 EPC1 EPC1 EPDR1 EVI2A FBXO4 FBXO6 FES FIGF FNTB FOXG1 FRK GBL GBL GNPDA2 GPER GPR176 GPX7 GTF2H4 GTF2IRD2 GTF2IRD2 GTF3C3 GTRGEO22 GULP1 HBP1 HCFC1 HIRIP3 HMGB2 HSD3B7 HTRA3 HTRA3 IL1RL1L IL1RN IL1RN ING4 IRX5 JMJD5 KCNK2 KCTD12B KRT10 LGR5 LOC100044776 LOC100046044 LOC100046883 LRBA LRRK1 MBD3 MC5R MCPH1 MCRS1 MD-2 MFAP5 MMP14 MRPL48 MTRF1 MYL4 MYLK MYLK N4BP2 N6AMT1 N6AMT1 NDUFAF1 NPEPL1 NPR3 NR1D2 NR1H3 NR2F2 NRN1 NSMAF NT5M NT5M NUSAP1 PANK1 PBK PCDHB22 PDGFRA PET112L PET112L PET112L PET112L PIK3C3 PIK3IP1 PKIG PLK1 PPA2 PPAPDC1 PRKCBP1 PRRG2 PUS3 QRSL1 RAB11B RASL11A RCBTB2 RHOBTB3 RNF103 RNF103 RPAP1 RPE RSPO2 RUNX1T1 S3-12 SCMH1 SDPR SEMA3A SETD1B SLC39A10 SMO SNX33 SPAG7 SPON2 SSPN STAG1 SUV420H1 SUV420H1 TAF9B TAPBPL TARBP2 TBC1D5 TCEAL8 TEAD2 TGF-B1I1 TGF-B1I1 TGF-B3 THNSL2 THTPA THTPA TMCO4 TMED1 TMEM17 TMEM209 TMEM42 TNFRSF11B TNFRSF12A TOR1AIP1 TPK1 TRAF3IP2 TRP63 TRUB1 TRUB1 TSGA14 TXNL4B UBTF ULK2 WISP2 ZFH4 ZFP236 ZFP236 ZFP521 ZFP532 ZFP532 ZFP710

genes regulated after 24 h in response to Porphyromonas gingivalis.

Upregulated ABCC3 ACTC1 ADAMTS7 ADORA2B AKP2 ANGPTL4 ARHGDIB ASNS AU018778 BCKDHB BCL3 BST2 C1S C3 C4B CAMP CASP4 CBR2 CCL17 CCL2 CCL5 CCL7 CCL9 CD14 CD68 CD74 CDC42EP3 CEBPB CFB CH25H CHAC1 CLIP1 COL18A1 COX7A1 CSGALNACT1 CTPS CX3CL1 CXCL1 CXCL10 CXCL15 CXCL2 CXCL4 CXCL9 CYP4F14 D12ERTD647E D14ERTD668E DCN DCXR DDT DDX58 DGAT2 DHX58 DNMT3L DTWD1 DUSP16 EG317677 EG630499 EGFL7 ENPP2 EREG ETS2 F13A1 FAS GADD45B GBP2 GBP3 GDNF GJA8 GP38 GSTT1 GSTT3 GYPC H2-AB1 H2-M3 H2-Q7 H2-T23 HAPLN4 HGF HIF1A HP HPX IER3 IFI27 IFI47 IFIT3 IFITM3 IFNAR2 IGTP IIGP2 IL10RB IL13RA1 IL13RA2 IL-1? IL-6 INSL6 IRAK3 IRF1 IRF9 JAK2 JUNB LBP LCN2 LMO4 LOC100038882 LOC100044190 LOC100044702 LOC100046232 LOC100048346 LOC100048710 LOC435337 LOC547343 LOC56628 LOC626578 LOC667370 LRRC8 LXN LY6A LY6C1 MACROD1 MAP3K8 MATN4 MFSD7 MMP12 MMP13 MMP3 MMP9 MT2 NAB1 NADK NFKB1 NFKB2 NFKBIA NFKBIE NFKBIZ NPY1R OASL2 ORM2 OSMR P2RX4 PARP14 PLA1A PLK2 PLSCR1 PLSCR2 PPBP PPP1R15B PRRX1 PSMD10 PTGS2 PTX3 RAC3 RASL12 RCAN1 RCL1 RELB RFFL RHOU RIOK3 RIPK2 RRBP1 RSN S100A8 SAA3 SARS SBNO2 SERPINA3F SERPINA3G SERPINB6B SERPINB9G SERPING1 SKIL SLC11A2 SLC15A3 SLC2A6 SLC7A2 SLCO1A5 SLIT2 SLPI SNX18 SOCS3 SOD2 SPHK1 STAT3 SUSD2 TCP10A TIMP1 TLR-2 TMEM176B TMOD1 TNFAIP3 TNFRSF9 TNFSF13B TNIP1 TRIB3 TRIM47 UBD UBE2L6 USP18 VEGF VNN3 WFDC12 ZC3H12A

Downregulated ABCA9 ALDH3A1 AQP1 ARNTL BACH2 BIRC5 BOK CAV1 CCND1 CDCA3 CDKN2C CENTG2 CHST1 CIRBP CLDN15 CTNNAL1 DIO3 DKK3 DRCTNNB1A EFNB1 EFNB2 ELA1 EMP1 ERMP1 EVI2A FDXR GAMT GPER GULP1 HIST1H2AD HIST1H2AF HIST1H2AG HIST1H2AH HIST1H2AK HIST1H2AN HIST1H2AO HIST2H2AB HTRA3 IL15 IL17RD IMPA2 INMT ITGA11 KCTD12B KRT13 LBH LOC100047651 MCM5 MGP MMD MYBL2 NDRG1 NDRL NRP1 NXPH2 OSR2 PACS2 PDK4 PDLIM2 PLXNA2 PPL PPP1R3C PRKCDBP PRR7 PTPRV PXMP4 RARB RDM1 RIN2 SEMA5A SERTAD4 SESN1 SLC40A1 SOX9 SPON2 SULT1A1 TCF19 TGF-B3 TGM5 TRP53INP1 VGLL4 VIM WNT5A ZFP521 ZFP608

Infectious Diseases / Bacteria / Viruses news headlines provided courtesy of Medical News Today.
 
 
   

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Last update: July 18, 2017