Enhanced links are provided by Diverse Kegg pathway analysis of GWAS and other networks

Host genes and proteins used by the Epstein-Barr virus during its life cycle

National Center for Infectious Diseases Epstein-Barr Virus and Infectious Mononucleosis Virus Human Interactome Network Map from The Dana-Farber Cancer institute at Harvard   Wikipedia  

 

    Viral proteins EBNA-1 EBNA-2 EBNA-3A EBNA-3B EBNA-3C EBNA-LP LMP-1 LMP-2A LMP-2B EBER

     

  1. IQCB1, IMPG1, IRF2BP2 and TPO: EBNA1 binding sites in the human genome d'Hérouël et al, 2010
  2. A2M alpha-2-macroglobulin: interacts with viral BFLF2 Rozenblatt-Rosen et al, 2012 see also VirHostome database for subsequent interactions related to this paper
  3. ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 : interacts with viral BALF1 VirHostome database
  4. ABCA13 ATP-binding cassette, sub-family A (ABC1), member 13: interacts with viral BNLF2A VirHostome database
  5. ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 : interacts with viral BHRF1 VirHostome database
  6. ABCD1 ATP-binding cassette, sub-family D (ALD), member 1: interacts with viral BVLF1 VirHostome database
  7. ABHD12 abhydrolase domain containing 12 : interacts with viral BDLF3.5 VirHostome database
  8. ABLIM3 actin binding LIM protein family, member 3: interacts with viral BALF1 VirHostome database
  9. ACBD3 acyl-CoA binding domain containing 3 : interacts with viral BALF1 VirHostome database
  10. ACOT9 acyl-CoA thioesterase 9 : interacts with viral BXLF1 VirHostome database
  11. ACSL3 acyl-CoA synthetase long-chain family member 3: interacts with viral BDLF3.5 VirHostome database
  12. ADAM9 ADAM metallopeptidase domain 9: interacts with viral BDLF4 VirHostome database
  13. ADAM10 ADAM metallopeptidase domain 10: interacts with viral BDLF4 VirHostome database
  14. ADAM28 – ADAM metallopeptidase domain 28: CCL3, CCL4, CXCL10, CXCL11, ITGA4, ITGB1, ADAM28, and ADAMDEC1, mRNA expression repressed by EBNA3C in EBNA3C-expressing B cells McClellan et al, 2012
  15. ADAMDEC1 – ADAM-like, decysin 1: CCL3, CCL4, CXCL10, CXCL11, ITGA4, ITGB1, ADAM28, and ADAMDEC1, mRNA expression repressed by EBNA3C in EBNA3C-expressing B cells McClellan et al, 2012
  16. ADCY6 adenylate cyclase 6: interacts with viral BALF1 VirHostome database
  17. ADCY9 adenylate cyclase 9 : interacts with viral BALF1 VirHostome database
  18. ADNP activity-dependent neuroprotector homeobox: interacts with viral BVLF1 VirHostome database
  19. ADRM1 adhesion regulating molecule 1 : interacts with viral BVLF1 VirHostome database
  20. AGK acylglycerol kinase: interacts with viral BNLF2A VirHostome database
  21. AGPAT6 1-acylglycerol-3-phosphate O-acyltransferase 6: interacts with viral BNLF2A VirHostome database
  22. AHCY – adenosylhomocysteinase: Involved in viral reactivation Maas et al, 2006
  23. AHCYL1 adenosylhomocysteinase-like 1 : interacts with viral EBNALP VirHostome database
  24. AHR – aryl hydrocarbon receptor: AhR ligands (e.g. dioxin) reactivate EBV in activated B cells and salivary epithelial cells Inoue et al, 2012
  25. AICDA activation-induced cytidine deaminase LMP1 increases mRNA expression and promoter activity in B cells via EGR1 Kim et al, 2013
  26. AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1 : interacts with viral BDLF4 VirHostome database
  27. AIP aryl hydrocarbon receptor interacting protein: Binds to EBNA3 Kashuba et al, 2000
  28. AKAP11 interacts with viral BDLF4 VirHostome database
  29. AKAP12 interacts with viral BDLF4 VirHostome database
  30. AKAP8L interacts with viral EBNALP VirHostome database
  31. AKT1 – v-akt murine thymoma viral oncogene homolog 1: Phosphorylation of AKT1 and its downstream targets IkappaB, FOXO1 inhibited by LMP1 siRNA in C666-1 cells Mei et al, 2007
  32. ALG1 interacts with viral BDLF4 VirHostome database
  33. ALG5 interacts with viral BNLF2A VirHostome database
  34. ALOX5 – arachidonate 5-lipoxygenase: activated by EBV in in human peripheral blood mononuclear cells Gosselin and Borgeat, 1997.
  35. ALYREF – Aly/REF export factor: essential for viral EB2-mediated mRNA export Hiriart et al, 2003
  36. AMER1 – APC membrane recruitment protein 1: LMP1 antagonizes WNT/ß-catenin signalling through inhibition of AMER1 QingLing et al, 2011
  37. ANK3 interacts with viral BNRF1 VirHostome database
  38. ANKRD13A interacts with viral BALF1 VirHostome database
  39. ANKRD40 interacts with viral BVLF1 VirHostome database
  40. ANXA1 Viral LMP1 mediates serine-phosphorylation of ANXA1 and ANXA2 by activating protein kinase C Yan et al, 2007.
  41. ANXA5 interacts with viral BALF1 VirHostome database
  42. ANXA6 interacts with viral BALF1 VirHostome database
  43. AP2B1 interacts with viral BPLF1 VirHostome database
  44. AP3B1 interacts with viral BXLF1 VirHostome database
  45. APOE genotype affects infectious mononucleosis risk (caused by EBV infection) Wozniak et al, 2007
    1. infectious mononucleosis (acute EBV infection) is associated with an altered serum lipid profile ; total cholesterol, HDL-C, LDL-C, apoAI, apoB, apoC-III and Lp(a) levels were lower at baseline and triglyceride levels and CETP activity were elevated acutely Apostolou et al, 2010
  46. ARAF interacts with viral BDLF4 VirHostome database
  47. ARGLU1 – arginine and glutamate rich 1: EBNALP associates with hairy and enhancer of split 1 (hes1), cd21, cd23, and arglu1 enhancer or promoter DNA Portal et al, 2011
  48. ARHGAP1 interacts with viral BFLF2 VirHostome database
  49. ARHGDIA interacts with viral BFRF0.5 VirHostome database
  50. ARL1 interacts with viral BDLF4 VirHostome database
  51. ASNA1 – arsA arsenite transporter, ATP-binding, homolog 1: BNLF2a acts as a tail-anchored protein, exploiting AASNA1/WRB for posttranslational insertion into the endoplasmic reticulum membrane, where it blocks antigen translocation by the transporter associated with antigen processing (TAP) Wycisk et al, 2011
  52. ASPH interacts with viral BDLF4 VirHostome database
  53. ATAD3A interacts with viral BALF1 VirHostome database
  54. ATF2 – activating transcription factor: EBV infection induces expression of the transcription factors ATF2/c-Jun in B lymphocytes Bandobashi et al, 2005
  55. ATF4 – activating transcription factor 4 : transactivates the LMP1 promoter. Lee and Sugden 2008
  56. ATF6 – activating transcription factor 6: LMP1 activates PERK, ERN1 and ATF6, 3 pathways of the unfolded protein response Lee and Sugden, 2006.
  57. ATM – ataxia telangiectasia mutated : promotes epstein-barr virus lytic reactivation Hagemeier et al, 2012
  58. ATP2A3 – ATPase, Ca++ transporting, ubiquitous (SERCA3): Latency type III infection of Burkitt's lymphoma cell lines with EBV expressing the full set of latency genes decreased ATP2A3 expression Dellis et al, 2009
  59. ATP11C interacts with viral BFRF0.5 VirHostome database
  60. ATP13A3 interacts with viral BALF1 VirHostome database
  61. ATP1A1 interacts with viral BHRF1 VirHostome database
  62. ATP2A2 interacts with viral BALF1 VirHostome database
  63. ATP2B4 interacts with viral BALF1 VirHostome database
  64. ATP2C1 interacts with viral BALF1 VirHostome database
  65. ATP5C1 interacts with viral BNLF2A VirHostome database
  66. ATP5H interacts with viral BNLF2A VirHostome database
  67. ATP5J interacts with viral BNLF2A VirHostome database
  68. ATP5L interacts with viral BNLF2A VirHostome database
  69. ATP5O interacts with viral BNLF2A VirHostome database
  70. ATP6 interacts with viral BNLF2A VirHostome database
  71. ATRX alpha thalassemia/mental retardation syndrome X-linked: interacts with viral BNRF1 VirHostome database
  72. ATXN2 interacts with viral BNRF1 VirHostome database
  73. AXL receptor tyrosine kinase interacts with viral BALF1 VirHostome database
  74. BABAM1 interacts with viral BVLF1 VirHostome database
  75. BACE2 interacts with viral BNLF2A VirHostome database
  76. BACH2 – BTB and CNC homology 1, basic leucine zipper transcription factor 2 EBV DNA is integrated into the host genome within BACH2 in a Burkitt lymphoma cell line Takakuwa et al, 2004
  77. BAG2 interacts with viral BNRF1 VirHostome database
  78. BAG3 interacts with viral BDLF4 VirHostome database
  79. BAG5 interacts with viral BNRF1 VirHostome database
  80. BAG6 interacts with viral BDLF4 VirHostome database
  81. BAK1 interacts with viral BHRF1 Kvansakul et al, 2010
  82. BANP BTG3 associated nuclear protein: interacts with viral EBNA3B VirHostome database
  83. BATF – basic leucine zipper transcription factor, ATF-like: EBNA2 and activated Notch induce expression of BATF Johansen et al, 2003.
  84. BAX interacts with viral BHRF1 VirHostome database
  85. BBC3 – BCL2 binding component 3: binds to BHRF1 Kvansakul et al, 2010
  86. BCL2A1 – BCL2-related protein A1: activated by EBNA2 via a CBF1/RBPJ kappa-dependent pathway Pegman et al, 2006
  87. BCL2L1 – BCL2-like 1 (Bim): downregulation of EBV with EBNA-1 siRNAs caused an increase in the expression of Bcl-xL in EBV infected Akata cells Lima et al, 2011
  88. BCL2L11 – BCL2-like 11 (apoptosis facilitator) binds to BHRF1 Kvansakul et al, 2010
  89. BDKRB2 interacts with viral BNLF2A VirHostome database
  90. BEND7 interacts with viral BSLF2/BMLF1 VirHostome database
  91. BICC1 interacts with viral BVLF1 VirHostome database
  92. BID – BH3 interacting domain death agonist binds to BHRF1 Kvansakul et al, 2010
  93. BIK interacts with viral BHRF1 VirHostome database
  94. BIRC5 baculoviral IAP repeat containing 5: marked upregulation in EBV-infected B-cells from tonsils along with CDK1 and CCNB1 Bernasconi et al, 2013
  95. BIRC6 – baculoviral IAP repeat containing 6: targeted by EBV encoded miR-BART15-3p microRNA Choi et al, 2013
  96. BLNK – B-cell linker: EBV infection causes constitutive tyrosine phosphorylation of one of the two SLP-65 (BLNK) isoforms and complex formation between SLP-65 and the protooncoprotein CrkL (CT10 regulator of kinase like).Engels et al, 2001
  97. BMI1 polycomb ring finger oncogene EBNA3A and EBNA3C associate with histone deacetylases BMI1, RING1 and CtBP1 Skalska et al, 2013
  98. BSG interacts with viral BALF1 VirHostome database
  99. BTF3 interacts with viral BFRF0.5 VirHostome database
  100. BTK – Bruton agammaglobulinemia tyrosine kinase: activation of Zp, the viral BZLF1 promoter requires the BCR-coupled protein tyrosine kinases Syk and Btk Lavens et al, 2004
  101. C5AR1 – complement component 5a receptor 1: EBV infection of tonsillar B cells increases expression Ehlin-Henriksson et al, 2009
  102. C19orf70 interacts with viral BNLF2A VirHostome database
  103. C1orf50 interacts with viral BBRF2 VirHostome database
  104. C20orf3 interacts with viral BDLF4 VirHostome database
  105. C2orf18 interacts with viral BNLF2A VirHostome database
  106. C4orf49 interacts with viral BHRF1 VirHostome database
  107. C5orf15 interacts with viral BALF1 VirHostome database
  108. C6orf182 interacts with viral BALF4 VirHostome database
  109. C6orf64 interacts with viral BNLF2A VirHostome database
  110. C9orf167 interacts with viral BALF1 VirHostome database
  111. CALCOCO2 interacts with viral BHRF1 VirHostome database
  112. CALR interacts with viral BALF1 VirHostome database
  113. CAND1 cullin-associated and neddylation-dissociated 1; interacts with viral BDLF4 VirHostome database
  114. CANX calnexin: interacts with viral BDLF4 VirHostome database
  115. CAP2 : CAP, adenylate cyclase-associated protein, 2: interacts with viral BRRF1 VirHostome database
  116. CAPN1 calpain 1, (mu/I) large subunit: interacts with viral BGLF3 VirHostome database
  117. CAPN2calpain 2, (m/II) large subunit: interacts with viral BTRF1 VirHostome database
  118. CAPZB capping protein (actin filament) muscle Z-line, beta: interacts with viral BXLF1 VirHostome database
  119. CASP1 – caspase 1, apoptosis-related cysteine peptidase: activated in EBV latency I Raji and other cells Ansari et al, 2013
  120. CASP3 – caspase 3, apoptosis-related cysteine peptidase : cells treated with LMP1 siRNA showed enhanced cleavage of caspase3 and PARP Mei et al, 2007
  121. Caspases CASP3, CASP7, CASP8 and CASP9 activated by LMP1 in lymphoblastoid cell lines Le Clorennec et al, 2008
  122. CAT – catalase : Induction of the Epstein-Barr viral lytic cycle in vitro causes oxidative stress in lymphoblastoid B cell lines and decreases superoxide dismutase and catalase activity Gargouri et al, 2009.
  123. CBL – Cbl proto-oncogene, E3 ubiquitin protein ligase: downregulates EBV LMP2A signaling Ikeda and Longnecker, 2009.
  124. CBS interacts with viral BDLF4 VirHostome database
  125. CBX5 interacts with viral BFRF0.5 VirHostome database
  126. CCDC14 interacts with viral BDLF1 VirHostome database
  127. CCDC155 interacts with viral BHRF1 VirHostome database
  128. CCDC165 interacts with viral BNRF1 VirHostome database
  129. CCDC168 interacts with viral BNLF2A VirHostome database
  130. CCDC33 interacts with viral BBRF3 VirHostome database
  131. CCDC67 interacts with viral EBNALP VirHostome database
  132. CCL1 – chemokine (C-C motif) ligand 1: EBV infection of tonsillar B cells increases expression (7 days post infection) Ehlin-Henriksson et al, 2009
  133. CCL2 – chemokine (C-C motif) ligand 2: LMP1 can induce the expression of RANTES(CCL5) and MCP-1 (CCL2) in an epithelial cell line Buettner et al, 2007 . EBV infection of tonsillar B cells reduces expression (7 days post infection) Ehlin-Henriksson et al, 2009
  134. CCL3 – chemokine (C-C motif) ligand 3: MIP-1 alpha: EBV-infected B cells secrete CCL3, CCL4 and CCL5 Nakayama et al, 2004
  135. CCL4 – chemokine (C-C motif) ligand 4 MIP-1-beta: EBV-infected B cells secrete CCL3, CCL4 and CCL5 Nakayama et al, 2004
  136. CCL5 – chemokine (C-C motif) ligand 5: LMP1 can induce the expression of RANTES(CCL5) and MCP-1 (CCL2) in an epithelial cell line Buettner et al, 2007 EBV infection of tonsillar B cells increases expression (7 days post infection) Ehlin-Henriksson et al, 2009
  137. CCL11 – chemokine (C-C motif) ligand 11: EBV infection of tonsillar B cells increases expression (7 days post infection) Ehlin-Henriksson et al, 2009
  138. CCL13 – chemokine (C-C motif) ligand 13: EBV infection of tonsillar B cells increases expression (7 days post infection) Ehlin-Henriksson et al, 2009
  139. CCL17 – chemokine (C-C motif) ligand 17: Viral LMP1 induces Th2 attracting chemokines CCL17 and CCL22 in human B cells Nakayama et al, 2004
  140. CCL19 – chemokine (C-C motif) ligand 19: EBV infection of tonsillar B cells increases expression Ehlin-Henriksson et al, 2009
  141. CCL20 – chemokine (C-C motif) ligand 20: EBV infection increases the expression of the chemokine CCL20 in both primary Hodgkin and Reed-Sternberg cells and Hodgkin and Reed-Sternberg cell-derived cell lines, via EBNA1 Baumforth et al, 2008 EBV infection of tonsillar B cells increases expression Ehlin-Henriksson et al, 2009
  142. CCL21 – chemokine (C-C motif) ligand 21; EBV infection affects the chemotactic response to CXCL13 and CCL21 (the ligands for CXCR5 and CCR7, respectively) with a reduction of ligand-induced migration at day 2 in tonsil B cells Ehlin-Henriksson et al, 2009.
  143. CCL22 – chemokine (C-C motif) ligand 22: Viral LMP1 induces Th2 attracting chemokines CCL17 and CCL22 in human B cells Nakayama et al, 2004
  144. CCL24 – chemokine (C-C motif) ligand 24: EBV infection of tonsillar B cells increases expression (7 days post infection) Ehlin-Henriksson et al, 2009
  145. CCND1 – cyclin D1 binds to EBNA3C Saha et al, 2011
  146. CCNDBP1 interacts with viral BNLF2B VirHostome database
  147. CCR2 – chemokine (C-C motif) receptor 2: EBV infection of tonsillar B cells increases expression Ehlin-Henriksson et al, 2009
  148. CCR6 – chemokine (C-C motif) receptor 6: Human B cells immortalized with Epstein-Barr virus upregulate CCR6 and CCR10 and downregulate CXCR4 and CXCR5 Nakayama et al, 2002. EBV infection of tonsillar B cells reduces expression (7 days post infection) Ehlin-Henriksson et al, 2009
  149. CCR7 – chemokine (C-C motif) receptor 7: EBV infection of tonsillar B cells reduces the expression of CXCR5, as well as of CCR7 Ehlin-Henriksson et al, 2009
  150. CCR9 – chemokine (C-C motif) receptor 9 : EBV infection of tonsillar B cells increases expression Ehlin-Henriksson et al, 2009
  151. CCR10 – chemokine (C-C motif) receptor 10: Human B cells immortalized with Epstein-Barr virus upregulate CCR6 and CCR10 and downregulate CXCR4 and CXCR5 Nakayama et al, 2002.
  152. CCRL2 – chemokine (C-C motif) receptor-like 2: EBV infection of tonsillar B cells reduces expression (7 days post infection) Ehlin-Henriksson et al, 2009
  153. CCT3 interacts with viral BDLF4 VirHostome database
  154. CCT5 interacts with viral BDLF3.5 VirHostome database
  155. CCT6A interacts with viral BDLF3.5 VirHostome database
  156. CCT6B interacts with viral BGLF3 VirHostome database
  157. CD5 – CD5 molecule: B cell expression regulated during Epstein-Barr virus transformation Kaplan et al, 2001.
  158. CD40 viral LMP1 is a functional mimic of the tumor necrosis factor receptor superfamily member CD40, utilizing tumor necrosis factor receptor-associated factor (TRAF) adaptor proteins to induce signaling Arcipowski et al, 2011.
  159. CD40LG – CD40 ligand: downregulates EBNA2 in activated T cells Nagy et al, 2012
  160. CD44 interacts with viral BALF1 VirHostome database
  161. CD58 – CD58 molecule: Expression modulated by the virus in lymphoma cell lines Calender et al, 1990
  162. CD69 molecule: viral LMP1 (CD40 mimic) upregulates CD69, CD80, and CD86 in B cells Panagopoulos et al, 2004
  163. CD80 molecule: viral LMP1 (CD40 mimic) upregulates CD69, CD80, and CD86 in B cells Panagopoulos et al, 2004
  164. CD86 molecule: viral LMP1 (CD40 mimic) upregulates CD69, CD80, and CD86 in B cells Panagopoulos et al, 2004
  165. CD248 interacts with viral BHRF1 VirHostome database
  166. CD274 ICOSLG inducible T-cell costimulator ligand: The virus upregulates T-cell inhibitory molecules B7-H1 (CD274) and ICOSLG in Plasmacytoid dendritic cells Severa et al, 2013
  167. CDC42 – cell division cycle 42: Viral LMP1 stimulates Cdc42-dependent filopodia formation as well as JNK and NF(kappa)B activation in fibroblasts Puls et al, 1999
  168. CDCP1 interacts with viral BALF1 VirHostome database
  169. CDH1 – cadherin 1, type 1, E-cadherin (epithelial):expression decreased by infection in epithelial cells Fåhraeus et al, 1992
  170. CDH2 – cadherin 2, type 1, N-cadherin (neuronal): LMP1 decreases overall levels of JUP but the remaining junctional plakoglobin was found associated with the LMP1 induced CDH2 in nasopharyngeal carcinoma cells Shair et al, 2009
  171. CDIPT interacts with viral BDLF4 VirHostome database
  172. CDKAL1 interacts with viral BDLF4 VirHostome database
  173. CDKN1A interacts with viral EBNALP VirHostome database
  174. CDKN1B – cyclin-dependent kinase inhibitor 1B (p27, Kip1) Phosphorylated by viral kinase BGLF4 Iwahori et al, 2009
  175. CDKN2A cyclin-dependent kinase inhibitor 2A: Repressed by viral EBNA3C Skalska et al, 2010
  176. CDS2 interacts with viral BDLF4 VirHostome database
  177. CEBPB – CCAAT/enhancer binding protein (C/EBP), beta: activates the promoter of the EBV lytic switch gene ZTA Shirley et al, 2011
  178. CEP170 interacts with viral BDLF4 VirHostome database
  179. CEP76 interacts with viral BBRF2 VirHostome database
  180. CEPT1 interacts with viral BHRF1 VirHostome database
  181. CFI – complement factor I: A viral protein acts as a cofactor for CFI Mold et al, 1988
  182. CGRRF1 interacts with viral BNLF2A VirHostome database
  183. CHCHD3 interacts with viral BHRF1 VirHostome database
  184. CHCHD4 interacts with viral BNLF2B VirHostome database
  185. CHEK2 binds to EBNA-3A Krauer et al, 2004
  186. CHP1 – calcineurin-like EF-hand protein 1: interacts with viral BDLF4 VirHostome database
  187. CHPF – chondroitin polymerizing factor ; interacts with viral BGLF3.5 VirHostome database
  188. CHPF2 – chondroitin polymerizing factor 2 interacts with viral BGLF3.5 VirHostome database
  189. CHRM2 cholinergic receptor, muscarinic 2\; interacts with viral BALF1 VirHostome database
  190. CHUK – conserved helix-loop-helix ubiquitous kinase: LMP1 uses two distinct pathways to activate NF-kappaB: via TRAF6/MAP3K7/IKBKB or TRAF3/MAP3K14/CHUK (noncanonical pathway) Wu et al, 2006.
  191. CKAP5 cytoskeleton associated protein 5; interacts with viral BNLF2A VirHostome database
  192. CLCN7 interacts with viral BALF1 VirHostome database
  193. CLEC7A interacts with viral BHRF1 VirHostome database
  194. CLPTM1 interacts with viral BNLF2A VirHostome database
  195. CLU interacts with viral BDLF4 VirHostome database
  196. CNN1 interacts with viral BVLF1 VirHostome database
  197. CNN2 interacts with viral BDLF4 VirHostome database
  198. CNOT1 interacts with viral BVLF1 VirHostome database
  199. CNP interacts with viral BALF1 VirHostome database
  200. CNTNAP1 interacts with viral BDLF4 VirHostome database
  201. COIL interacts with viral BSLF2/BMLF1 VirHostome database
  202. COL6A1 interacts with viral BDLF3.5 VirHostome database
  203. COL6A2 interacts with viral BDLF3.5 VirHostome database
  204. COL6A3 interacts with viral BDLF3.5 VirHostome database
  205. COMT interacts with viral BDLF3.5 VirHostome database
  206. COPA interacts with viral BDLF4 VirHostome database
  207. COPB1 interacts with viral BNLF2A VirHostome database
  208. COPB2 interacts with viral BNLF2A VirHostome database
  209. COPE interacts with viral BDLF4 VirHostome database
  210. COX2 interacts with viral BHRF1 VirHostome database
  211. CPT1A interacts with viral BNLF2A VirHostome database
  212. CR1 complement component (3b/4b) receptor 1 (Knops blood group) Viral receptor Ogembo et al, 2013
  213. CR2 – complement component (3d/Epstein Barr virus) receptor 2 EBV receptor Fingeroth et al, 1984
  214. CREB3 interacts with viral BNLF2A VirHostome database
  215. CREBBP interacts with viral BRLF1 VirHostome database
  216. CRH – corticotropin releasing hormone ; enhances the lytic replication of the HR-1 strain of EBV in superinfected cells Glaser et al, 1995
  217. CRIM1 interacts with viral BALF1 VirHostome database
  218. CRIP2 interacts with viral BGLF3 VirHostome database
  219. CRKL – v-crk sarcoma virus CT10 oncogene homolog (avian)-lik: EBV infection causes constitutive tyrosine phosphorylation of one of the two BLNK isoforms and complex formation between BLNK and CRKL .Engels et al, 2001
  220. CRYBG3 interacts with viral BDLF4 VirHostome database
  221. CSF1 – colony stimulating factor 1 (macrophage) neutralised by viral BARF1 Elegheert et al, 2012
  222. CSF2 – colony stimulating factor 2 (granulocyte-macrophage) : upregulated by viral Zta and secreted from nasopharyngeal carcinoma cells Lee et al, 2011
  223. CSK – c-src tyrosine kinase: phosphorylates LMP2A Scholle et al, 1999
  224. CSNK2A1 casein kinase II subunit alpha isoform a: interacts with viral EBNA1 Malik-Soni and Frappier, 2012
  225. CSNK2B interacts with viral EBNA1 VirHostome database
  226. CSPG4 interacts with viral BHRF1 VirHostome database
  227. CSRP2 interacts with viral BDLF4 VirHostome database
  228. CTBP1 C-terminal binding protein 1: EBNA3A and EBNA3C associate with histone deacetylases BMI1, RING1 and CtBP1 Skalska et al, 2013
  229. CTCF – CCCTC-binding factor (zinc finger protein) Binds to several sites in the viral genome Tempera at al, 2010
  230. CTNNA1 interacts with viral BALF1 VirHostome database
  231. CTNNB1 – catenin (cadherin-associated protein), beta 1, 88kDa: LMP2A activates beta-catenin signaling in epithelial cells.Morrison et al, 2003
  232. CTNND1 interacts with viral BALF1 VirHostome database
  233. CTSB interacts with viral BDLF4 VirHostome database
  234. CTSH – cathepsin H: Expression increased by infection in B cells Birkenbach et al, 1993
  235. CUBN interacts with viral LMP2A VirHostome database
  236. CUL1 cullin 1: induction of the productive virus cycle was accompanied by a gradual decrease of Cul1, Cul3, Cul4A and Cul5 expression Gastaldello et al, 2010
  237. CXCL2 CXCL2 – chemokine (C-X-C motif) ligand 2: EBV infection of tonsillar B cells reduces expression (7 days post infection) Ehlin-Henriksson et al, 2009
  238. PPBP – pro-platelet basic protein (chemokine (C-X-C motif) ligand 7): (CXCL7) EBV infection of tonsillar B cells increases expression (7 days post infection) Ehlin-Henriksson et al, 2009
  239. CXCL10 – chemokine (C-X-C motif) ligand 10: CCL3, CCL4, CXCL10, CXCL11, ITGA4, ITGB1, ADAM28, and ADAMDEC1, mRNA expression repressed by EBNA3C in EBNA3C-expressing B cells McClellan et al, 2012
  240. CXCL11 – chemokine (C-X-C motif) ligand 11 See above McClellan et al, 2012
  241. CXCL12 – chemokine (C-X-C motif) ligand 12: in lymphoblastoid cell lines, CXCL12 is up-regulated by EBNA2C via the latter's interaction with the transcription factor RBPJ Zhao et al, 2011
  242. CXCR3 – chemokine (C-X-C motif) receptor 3 : EBV infection of tonsillar B cells increases expression (7 days post infection) Ehlin-Henriksson et al, 2009
  243. CXCR4 – chemokine (C-X-C motif) receptor 4: induced by viral LMP1 and associated with the metastatic potential of human nasopharyngeal carcinoma Xu et al, 2013.
  244. CXCR5 – chemokine (C-X-C motif) receptor 5: Human B cells immortalized with Epstein-Barr virus upregulate CCR6 and CCR10 and downregulate CXCR4 and CXCR5 Nakayama et al, 2002. EBV infection of tonsillar B cells reduces the expression of CXCR5, as well as of CCR7 Ehlin-Henriksson et al, 2009
  245. CXCR7 – chemokine (C-X-C motif) receptor 7: Upregulated by EBNA2 in EBV immortalised lymphocytes Cancian et al, 2011
  246. CYBRD1 interacts with viral BNLF2A VirHostome database
  247. CYCS cytochrome c, somatic : etoposide-triggered apoptosis,and caspase-2 and 3 activation, is enhanced by LMP1as is the release of cytochrome c Zhang et al, 2005.
  248. DARS interacts with viral BDLF4 VirHostome database
  249. DAXX death-domain associated protein: interacts with viral BNRF1 VirHostome database
  250. DDIT3 – DNA-damage-inducible transcript 3 (CHOP): LMP1 transfection increased the expression of HSPA5 and XBP1, but attenuated the expression of death signals, CHOP and MAP3K5 Chang et al, 2011
  251. DDOST interacts with viral BDLF4 VirHostome database
  252. DDR2 interacts with viral BNLF2A VirHostome database
  253. DDX6 interacts with viral BHRF1 VirHostome database
  254. DDX20 DEAD (Asp-Glu-Ala-Asp) box polypeptide 20 (Gemin3) Stabilised by EBNA3C Cai et al, 2011
  255. DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 (RIG-1) Epstein-Barr virus-encoded small RNAs, transcribed by RNA polymerase III then trigger RIG-I activation Ablasser et al, 2009.
  256. DGAT1 interacts with viral BNLF2A VirHostome database
  257. DHCR24 interacts with viral BNLF2A VirHostome database
  258. DHRS7 interacts with viral BNLF2A VirHostome database
  259. DLG1 interacts with viral BALF1 VirHostome database
  260. DNAH1 interacts with viral BDLF4 VirHostome database
  261. DNAJA1 interacts with viral BALF1 VirHostome database
  262. DNAJA3 interacts with viral BDLF4 VirHostome database
  263. DNAJB1 interacts with viral BNRF1 VirHostome database
  264. DNAJB12 interacts with viral BHRF1 VirHostome database
  265. DNAJB2 interacts with viral BDLF4 VirHostome database
  266. DNAJB4 interacts with viral BALF1 VirHostome database
  267. DNAJB5 interacts with viral EBNALP VirHostome database
  268. DNAJB6 interacts with viral EBNALP VirHostome database
  269. DNAJC13 interacts with viral EBNALP VirHostome database
  270. DNAJC16 interacts with viral BALF1 VirHostome database
  271. DNAJC7 interacts with viral BNRF1 VirHostome database
  272. DNMT1 – DNA (cytosine-5-)-methyltransferase 1: LMP1 induces promoter hypermethylation of RARB via up-regulation of DNA methyltransferases 1, 3a, and 3b in nasopharyngeal carcinoma cells Seo et al, 2008
  273. DNMT3A – DNA (cytosine-5-)-methyltransferase 3 alpha: See Seo et al, 2008
  274. DNMT3B – DNA (cytosine-5-)-methyltransferase 3 beta: See Seo et al, 2008
  275. DOCK11 interacts with viral BFRF0.5 VirHostome database
  276. DOCK9 interacts with viral BFRF0.5 VirHostome database
  277. DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1) infection of primary human B-cells leads to the down-regulation of DOK1 gene expression via the viral oncoprotein LMP1 Siouda et al, 2014
  278. DPM1 interacts with viral BDLF4 VirHostome database
  279. DPP7 interacts with viral BDLF4 VirHostome database
  280. DPY19L1 interacts with viral BHRF1 VirHostome database
  281. DVL2 interacts with viral BLRF2 VirHostome database
  282. DYNC1H1 interacts with viral BDLF4 VirHostome database
  283. E2F4 – E2F transcription factor 4, p107/p130-binding: LMP1 ablocks the function of E2F4 and E2F5 by promoting their nuclear export in a XPO1-dependent manner Ohtani et al, 2003
  284. E2F5 – E2F transcription factor 5, p130-binding:
  285. EBI3 – Epstein-Barr virus induced 3
  286. EBNA1BP2 Binds to EBNA1 Jourdan et al, 2012
  287. EBVS1 – Epstein Barr virus integration site 1
  288. ECE1 interacts with viral BDLF4 VirHostome database
  289. EEF1B2 interacts with viral BFRF0.5 VirHostome database
  290. EEF1D – eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) Phosphorylated by BGLF4 Kawaguchi et al, 2003
  291. EFEMP2 interacts with viral BDLF4 VirHostome database
  292. EFNB1 interacts with viral BNLF2A VirHostome database
  293. EGFR interacts with viral BALF1 VirHostome database
  294. EGLN1 – egl nine homolog 1 (C. elegans): EBNA-5 and EBNA-3 bind to prolylhydroxylases 1 and 2, (EGLN1 EGLN2) respectively, thus inhibiting HIF1A hydroxylation and degradation Darekar et al, 2012.
  295. EGLN2 – egl nine homolog 2 (C. elegans) see above Darekar et al, 2012.
  296. EGR1 early growth response 1: LMP1 increases mRNA expression and promoter activity in B cells via EGR1 Kim et al, 2013
  297. EHD2 interacts with viral BDLF4 VirHostome database
  298. EHMT1 interacts with viral BFRF0.5EI24 interacts with viral BNLF2A VirHostome database
  299. EIF2AK2 – eukaryotic translation initiation factor 2-alpha kinase 2 (pkr) Interacts with viral EBER1 and Sharp et al, 1993
  300. EIF2AK3 – eukaryotic translation initiation factor 2-alpha kinase 3 (perk) : LMP1 activates PERK, ERN1 and ATF6, 3 pathways of the unfolded protein response Lee and Sugden, 2006.
  301. EIF2S1 – eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa: EBNA3C maintains phosphorylation of eIF2alpha at serine 51 Garrido et al, 2009
  302. EIF4EBP1 – eukaryotic translation initiation factor 4E binding protein 1: MTOR activation by LMP2A in carcinoma cells leads to EIF4EBP1 inhibition and increased c-Myc protein translation Moody et al, 2005
  303. ELK1 – ELK1, member of ETS oncogene family; viral Zta binds to the Egr-1 promoter and activates the ERK signaling pathway to trigger binding of Elk1 to the Egr-1 promoter Chang et al, 2006
  304. EMD interacts with viral BALF1 VirHostome database
  305. EMILIN1 interacts with viral BVLF1 VirHostome database
  306. ENG interacts with viral BNLF2A VirHostome database
  307. ENPP1 interacts with viral BHRF1 VirHostome database
  308. ENPP2 – ectonucleotide pyrophosphatase/phosphodiesterase 2 (autotaxin): EBV infection of Hodgkin lymphoma cells results in the induction of autotaxin Baumforth et al, 2005
  309. EP300 interacts with viral BRLF1 VirHostome database
  310. EPHB2 interacts with viral BALF1 VirHostome database
  311. EPHB4 interacts with viral BALF1 VirHostome database
  312. EPN1 interacts with viral BALF1 VirHostome database
  313. EPRS interacts with viral BDLF4 VirHostome database
  314. ERBB2 interacts with viral BALF1 VirHostome database
  315. ERC1 interacts with viral BALF1 VirHostome database
  316. EREG – epiregulin : EGFR ligands (TGFA, HBEGF and epiregulin) are constitutively induced by LMP1 in mice expressing the Cao strain of LMP1 in epithelia Charalambous et al, 2007
  317. ERGIC1 interacts with viral BDLF4 VirHostome database
  318. ERGIC3 interacts with viral BALF1 VirHostome database
  319. ERLIN1 interacts with viral BHRF1 VirHostome database
  320. ERLIN2 interacts with viral BNLF2A VirHostome database
  321. ERN1 – endoplasmic reticulum to nucleus signaling 1: LMP1 activates PERK, ERN1 and ATF6, 3 pathways of the unfolded protein response Lee and Sugden, 2006.
  322. ESRRA estrogen-related receptor alpha: binds to EBNALP Igarashi et al, 2003
  323. ESRRG interacts with viral EBNALP VirHostome database
  324. ESYT1 interacts with viral BNLF2A VirHostome database
  325. ESYT2 interacts with viral BHRF1 VirHostome database
  326. ETS1 ETS proto-oncogene 1, transcription factor: LMP1 upregulates immunoglobulin K 3' enhancer activity and kappa gene expression by activating the Ets-1 transcription factor through the ERKs signaling pathway Liu et al, 2012
  327. ETS2 – v-ets erythroblastosis virus E26 oncogene homolog 2 (avian): LMP1 promotes the XPO1-dependent nuclear export of Ets2 Ohtani et al, 2003
  328. EXOC5 interacts with viral BHRF1 VirHostome database
  329. EZR ezrin : LMP1 enhances the organization of a ternary complex of CD44, ezrin and F-actin in nasopharyngeal carcinoma tissue Endo et al, 2009
  330. F2R interacts with viral BALF1 VirHostome database
  331. FAF2 interacts with viral LMP2A VirHostome database
  332. PTK2 – protein tyrosine kinase 2: (FAK) Inhibition of FAK or its signaling mediator Src kinase inhibits LMP2A-induced migration of human foreskin keratinocytes: LMP2A also induced GSK3ß phosphorylation Fotheringham et al, 2012
  333. FAM176A interacts with viral BHRF1 VirHostome database
  334. FAM176B interacts with viral BNLF2A VirHostome database
  335. FAM178A interacts with viral BVLF1 VirHostome database
  336. FAM192A interacts with viral LMP2A VirHostome database
  337. FAM36A interacts with viral BHRF1 VirHostome database
  338. FAM82A2 interacts with viral BHRF1 VirHostome database
  339. FARP1 interacts with viral EBNA1 VirHostome database
  340. FARSA interacts with viral BDLF4 VirHostome database
  341. FAS interacts with viral BDLF4 VirHostome database
  342. FASN interacts with viral BGLF3 VirHostome database
  343. FAT1 interacts with viral BALF1 VirHostome database
  344. FATE1 interacts with viral BHRF1 VirHostome database
  345. FCER2 – Fc fragment of IgE, low affinity II, receptor for (CD23): regulated by the virus Shieh et al, 1997
  346. FCRL5 – Fc receptor-like 5: Expression induced by EBNA2 via RBPL (cbf1) Mohan et al, 2006.
  347. FGD4 – FYVE, RhoGEF and PH domain containing 4: Interacts with LMP1 Liu et al, 2012
  348. FGF2 – fibroblast growth factor 2 (basic): LMP1 promotes expression of FGF2, and the release of its 18-kDa isoform Ceccarelli et al, 2007
  349. FHL2 interacts with viral BDLF4 VirHostome database
  350. FHOD1 – formin homology 2 domain containing 1: EBV attachment to CD21 stimulates FHOD1 redistribution and co-aggregation with CD21 Gill et al, 2004
  351. FILIP1L interacts with viral BVLF1 VirHostome database
  352. FKBP15 interacts with viral BFRF0.5 VirHostome database
  353. FKBP1A interacts with viral BALF1 VirHostome database
  354. FKBP9 interacts with viral BDLF4 VirHostome database
  355. FN1 interacts with viral BALF1 VirHostome database
  356. FNDC3B interacts with viral BHRF1 VirHostome database
  357. FOXF1 interacts with viral BDLF4 VirHostome database
  358. FOXO1 – forkhead box O1: Phosphorylation of AKT1 and its downstream targets IkappaB, FOXO1 inhibited by LMP1 siRNA in C666-1 cells Mei et al, 2007
  359. FOXO3 forkhead box O3: Viral LMP1 triggers the PI3K/Akt pathway to inactivate FOXO3 and decrease DDB1, which can lead to repression of DNA repair Chen et al, 2008
  360. FTH1 interacts with viral BFLF2 VirHostome database
  361. FYN – FYN oncogene related to SRC, FGR, YES: Lck and Fyn are recruited to the tyrosine-phosphorylated Tyr112 site in LMP2A in T cells Ingham et al, 2005
  362. FZD6 interacts with viral BNLF2A VirHostome database
  363. GALNT1 interacts with viral BNLF2A VirHostome database
  364. GALNT5 interacts with viral BDLF4 VirHostome database
  365. GAS6 interacts with viral BDLF3.5 VirHostome database
  366. GAST – gastrin: Viral BMRF1 activates transcription of gastrin in telomerase-immortalized keratinocytes Holley-Guthrie et al, 2005
  367. GBF1 interacts with viral BDLF4 VirHostome database
  368. GCN1L1 interacts with viral BDLF4 VirHostome database
  369. GET4 interacts with viral BVLF1 VirHostome database
  370. GFPT1 interacts with viral BDLF4 VirHostome database
  371. GGCX interacts with viral BDLF4 VirHostome database
  372. GGT7 interacts with viral BDLF4 VirHostome database
  373. GKN1 gastrokine 1: EBNA1 binds to the divergent promoter of the GKN1 and GKN2 genes Lu et al, 2014
  374. GKN2 gastrokine 2: EBNA1 binds to the divergent promoter of the GKN1 and GKN2 genes Lu et al, 2014
  375. GIF interacts with viral EBNA1 VirHostome database
  376. GJA1 interacts with viral BNLF2A VirHostome database
  377. GLG1 interacts with viral BHRF1 VirHostome database
  378. GLIPR1 interacts with viral BNLF2A VirHostome database
  379. GLIPR2 interacts with viral BNLF2A VirHostome database
  380. GMCL1 interacts with viral EBNA3B VirHostome database
  381. GMPS GMP synthase [glutamine-hydrolyzing] :interacts with viral EBNA1 Malik-Soni and Frappier, 2012
  382. GNG2 interacts with viral BHRF1 VirHostome database
  383. GNPTAB interacts with viral BHRF1 VirHostome database
  384. GNPTG interacts with viral BHRF1 VirHostome database
  385. GNS interacts with viral BNLF2A VirHostome database
  386. GOLGA2 interacts with viral BBRF2 VirHostome database
  387. GPD2 interacts with viral BNLF2A VirHostome database
  388. GPR31 – G protein-coupled receptor 31: EBV infection of tonsillar B cells reduces expression (7 days post infection) Ehlin-Henriksson et al, 2009
  389. GPR183 – G protein-coupled receptor 183: Expression increased by infection in B cells Birkenbach et al, 1993
  390. GPRASP2 interacts with viral BFLF2 VirHostome database
  391. GPX8 interacts with viral BDLF4 VirHostome database
  392. GREM1 interacts with viral BALF1 VirHostome database
  393. GSK3B – glycogen synthase kinase 3 beta: LMP2A induced GSK3ß phosphorylation in human foreskin keratinocytesFotheringham et al, 2012
  394. GSTA4 glutathione S-transferase alpha 4: interacts with viral BALF2 VirHostome database
  395. GTF2H1 – general transcription factor IIH, polypeptide 1, 62kDa: The p89 (ERCC3), p80 (ERCC2), and p62 (GTF2H1) subunits of TFIIH bind to EBNA2: the p34 (GTF2H3) subunit of TFIIH only bound in the presence of p62 Tong et al, 1995
  396. HAX1 interacts with viral EBNALP VirHostome database
  397. HBEGF – heparin-binding EGF-like growth factor : EGFR ligands (TGFalpha HBEGF and epiregulin) are constitutively induced by LMP1 in mice expressing the Cao strain of LMP1 in epithelia Charalambous et al, 2007
  398. HCCS interacts with viral BNLF2A VirHostome database
  399. HDAC1 – histone deacetylase 1: viral BGLF4 interacts with HDAC1 Mounce et al, 2013
  400. HDAC3 – histone deacetylase 3 : EBNA1 binds close to the transcriptional start sites of cellular genes, including HDAC3, CDC7, and MAP3K1, which are positively regulated by EBNA1 Lu et al, 2010.
  401. HDAC4 – histone deacetylase 4: viral EBNA5 coactivates transcription by displacing HDAC4 from EBNA2-bound promoter sites Tacaks et al, 2009
  402. HDGFRP2 interacts with viral BFRF0.5 VirHostome database
  403. HDLBP interacts with viral BDLF4 VirHostome database
  404. HELZ interacts with viral BVLF1 VirHostome database
  405. HES1 – hairy and enhancer of split 1: EBNALP associates with hairy and enhancer of split 1 (hes1), cd21, cd23, and arginine and glutamate-rich 1 (arglu1) enhancer or promoter DNA Portal et al, 2011
  406. HIF1A – hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor): EBNA-5 and EBNA-3 bind to prolylhydroxylases 1 and 2, (EGLN1 EGLN2) respectively, thus inhibiting HIF1A hydroxylation and degradation Darekar et al, 2012.
  407. HM13 interacts with viral BNLF2A VirHostome database
  408. HLA-DRB1 influences T-cell responses to the virakl gp110 antigen Toussirot et al, 1999
  409. HMGA2 interacts with viral EBNA1 VirHostome database
  410. HMGB2 binds to EBNA1 Jourdan et al, 2012
  411. HMHA1 histocompatibility (minor) HA-1 : Involved in bystander suppression : When viral antigen , myeloid dendritic cells , and T cells were coinjected along with HMAH1 (HA-1H) peptide, the antiviral anti-EBV response was inhibited Derks et al, 2007
  412. HMOX2 interacts with viral BNLF2A VirHostome database
  413. HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) (AUF1) Binds to viral EBER1 Lee et al, 2012
  414. HNRNPK – heterogeneous nuclear ribonucleoprotein K interacts with viral BDLF2 VirHostome database
  415. HNRNPM – heterogeneous nuclear ribonucleoprotein M: associates with EBNA5 Forsman et al, 2008
  416. HOMER3 interacts with viral BFRF1 VirHostome database
  417. HP1BP3 interacts with viral EBNA1 VirHostome database
  418. HPS6 interacts with viral BVLF1 VirHostome database
  419. HRAS – v-Ha-ras Harvey rat sarcoma viral oncogene homolog: activated by LMP2A in lymphocytes Portis and Longnecker, 2004
  420. HSDL1 interacts with viral BNLF2A VirHostome database
  421. HSPA4 interacts with viral BVLF1 VirHostome database
  422. HSPB8 interacts with viral EBNALP VirHostome database
  423. HTT interacts with viral BGLF3 VirHostome database
  424. IARS interacts with viral BDLF4 VirHostome database
  425. ICAM1 interacts with viral BDLF4 VirHostome database
  426. ICMT interacts with viral BHRF1 VirHostome database
  427. ICOSLG inducible T-cell costimulator ligand: The virus upregulates T-cell inhibitory molecules B7-H1 (CD274) and ICOSLG in Plasmacytoid dendritic cells Severa et al, 2013
  428. IFI16 – interferon, gamma-inducible protein 16: sensing of the latent EBV genome by IFI16 results in the constitutive induction of the inflammasome and IL-1ß, IL-18 and IL-33 maturation in EBV latency I Raji cells, latency II NPC C666-1 cells and latency III lymphoblastoid cells Ansari et al, 2013.
  429. IFNA1 interferon, alpha 1: upregulates latent membrane protein 1 (LMP-1) expression by direct activation of the ED-L1 promoter in Epstein-Barr virus -carrying Burkitt's lymphoma lines Salomon et al, 2012
  430. IFNAR1 interferon (alpha, beta and omega) receptor 1: Viral LMP2A and LMP2B increase the turnover and degradation of IFNAR1 and IFNGR1 Shah et al, 2009
  431. IFNG – interferon, gamma: Viral BZLF1 decreases the ability of IFN-gamma to activate downstream target genes, such as IRF1, IRF9 (p48), and CIITA, and prevents IFN-gamma-induced class II MHC surface expression
  432. IFNGR1 interacts with viral BALF1 VirHostome database
  433. IGF1R – insulin-like growth factor 1 receptor: EBV infection decreased binding in Burkitt lymphoma cells Kriauciunas et al, 1993
  434. IGF2BP1 interacts with viral EBNA1 VirHostome database
  435. IGF2BP2 interacts with viral BVLF1 VirHostome database
  436. IGF2BP3 interacts with viral EBNA1 VirHostome database
  437. IGF2R interacts with viral BDLF4 VirHostome database
  438. IGFBP4 interacts with viral BGLF3 VirHostome database
  439. IGKC immunoglobulin kappa constant; LMP1 upregulates the activity of IGKC in nasopharyngeal cancer cells Liu et al, 2012.
  440. IKBIP interacts with viral BALF1 VirHostome database
  441. IL1B – interleukin 1, beta : sensing of the latent EBV genome by IFI16 results in the constitutive induction of the inflammasome and IL-1ß, IL-18 and IL-33 maturation in EBV latency I Raji cells, latency II NPC C666-1 cells and latency III lymphoblastoid cells Ansari et al, 2013.
  442. IL1RN – interleukin 1 receptor antagonist: synthesis induced by EBV in neutrophils Beaulieu et al, 1995
  443. IFNA2 – interferon, alpha 2 :Infection of monocytes with EBV induced IFNalpha secretion Michaud et al, 2010
  444. IFNB1 – interferon, beta 1, fibroblast; Viral BRLF1 inhibits IRF3 and IRF7 transcription and suppresses induction of interferon-beta induction.Bentz et al, 2010
  445. IFNG – interferon, gamma: polymorphisms modify the risk of EBV reactivation in man Bogunia-Kubik et al, 2006
  446. IKZF1 IKAROS family zinc finger 1 (Ikaros) : complexes with the EBV immediate-early R protein Iempridee et al, 2014
  447. IL4 – interleukin 4: exposure to IL-4 or IL-13 alone induces viral LMP-1 in the absence of EBNA-2 in the KMH2-EBV cell line Kis et al, 2011
  448. IL6 – interleukin 6 (interferon, beta 2): LMP1 regulates IL6 production in epithelial cells in a manner similar to CD40 ligation Eliopoulos et al, 1997
  449. IL6R – interleukin 6 receptor: EBV infection in vitro leads to an up-regulation of IL-6R mRNA in Burkitt's lymphoma cells Tomeczkowsk et al, 1997
  450. IL6ST interacts with viral BALF1 VirHostome database
  451. IL8 – interleukin 8: Transfection with LMP1 induced IL-8 protein expression in C33A cells Yoshizaki et al, 2001
  452. IL12A – interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35) : interleukin-12 is a heterodimeric cytokine of 70 kDa formed by IL12A and IL12B . originally identified and purified from the supernatant of Epstein-Barr virus-transformed B cell lines Trinchieri et al, 1992
  453. IL13 – interleukin 13: exposure to IL-4 or IL-13 alone induces viral LMP-1 in the absence of EBNA-2 in the KMH2-EBV cell line Kis et al, 2011 Viral Zta binds to the IL-13 promoter Tsai et al, 2009
  454. IL15 – interleukin 15: curtails infections by 3 human herpesviruses: Herpes simplex virus type 1, Epstein-Barr virus, and human herpesvirus 6 via natural killer cells Gosselin et al, 1999
  455. IL16 – interleukin 16: Induced by viral EBNA2 in B cells Spender et al, 2002
  456. IL18 – interleukin 18 (interferon-gamma-inducing factor): IL-18 serum concentration is markedly elevated in acute EBV infection van de Veerdonk et al, 2012
  457. IL18R1 interleukin 18 receptor 1: EBNA2 induces expression of the 2 chains of the interleukin-18 receptor in Burkitt lymphoma cell lines and in nontransformed B cells Pages et al, 2005
  458. IL18RAP – interleukin 18 receptor accessory protein: see above Pages et al, 2005
  459. IL21 – interleukin 21: regulates expression of viral EBNA2 and LMP1 in infected human B cells Konforte et al, 2008.
  460. IL33 – interleukin 33: sensing of the latent EBV genome by IFI16 results in the constitutive induction of the inflammasome and IL-1ß, IL-18 and IL-33 maturation in EBV latency I Raji cells, latency II NPC C666-1 cells and latency III lymphoblastoid cells Ansari et al, 2013.
  461. IMMT interacts with viral BHRF1 VirHostome database
  462. INF2 interacts with viral BALF1 VirHostome database
  463. INSR – insulin receptor: LMP1 increases insulin receptor expression in Burkitt lymphoma cells Kriauciunas et al, 1993
  464. IPO5 interacts with viral BDLF4 also binds to EBNA1 Holowaty et al, 2003
  465. IPO9 interacts with viral BNLF2A VirHostome database
  466. IRAK1 – interleukin-1 receptor-associated kinase 1: IRAK1 and TRAF6 are essential for LMP1-induced NF-kappaB activation Luftig et al, 2003
  467. IRF3 interact with the BGLF4 protein Wang et al, 2009
  468. IRF4 IRF4 – interferon regulatory factor 4: viral EBNA3C physically interacts with IRF4 and IRF8 Banerjee et al, 2013
  469. IRF5 – interferon regulatory factor 5: induced by EBV infection in B cells Martin et al, 2007
  470. IRF7 – interferon regulatory factor 7 : EBNA1 regulates IRF7 function by inducing its sumoylation by SUMO1 via EBNA1/UBE2I interaction Bentz et al, 2012.
  471. IRF8 – interferon regulatory factor 8: viral EBNA3C physically interacts with IRF4 and IRF8 Banerjee et al, 2013
  472. ISG15 interacts with viral BNLF2A VirHostome database
  473. ITCH – itchy E3 ubiquitin protein ligase: interacts with viral LMP2A Seo et al, 2007
  474. ITFG1 interacts with viral BHRF1 VirHostome database
  475. ITGA4 – integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) : CCL3, CCL4, CXCL10, CXCL11, ITGA4, ITGB1, ADAM28, and ADAMDEC1, mRNA expression repressed by EBNA3C in EBNA3C-expressing B cells McClellan et al, 2012
  476. ITGAV – integrin, alpha V; upregulated by EBNA3C Choudhuri et al, 2006
  477. ITGB1 interacts with viral BALF1 VirHostome database
  478. ITGB6 Integrins ITGAV/ITGB6 and ITGAV/ITGB8 can serve as specific receptors for viral gHgL and can provide the trigger for direct virus fusion with the epithelial cell plasma membrane . Hutt-Fletcher and Chesnokova, 2010
  479. ITIH3 interacts with viral BNLF2B VirHostome database
  480. ITM2C interacts with viral BALF1 VirHostome database
  481. ITSN1 – intersectin 1 (SH3 domain protein): LMP2A regulates phosphorylation of ITSN1 and Shb adaptors by tyrosine kinases Dergai et al, 2013.
  482. IWS1 interacts with viral BFRF0.5 VirHostome database
  483. JAK1 interacts with viral BALF1 Rozenblatt-Rosen et al, 2012 see also VirHostome database
  484. JAK3 – Janus kinase 3: Interacts with LMP1 activating STAT signalling Gires et al, 1999
  485. JAKMIP2 interacts with viral BXLF1 VirHostome database
  486. JDP2 – Jun dimerization protein 2: associates with the viral BZLF1 promoter Murata et al, 2011
  487. JUN – jun proto-oncogene: JunB forms a heterodimeric complex with JUN under the regulation of viral LMP1 Song et al, 2005
  488. JUNB – jun B proto-oncogene: JunB forms a heterodimeric complex with JUN under the regulation of viral LMP1 Song et al, 2005
  489. JUP – junction plakoglobin: LMP1 decreases overall levels of JUP but the remaining junctional plakoglobin was found associated with the LMP1 induced N-cadherin (CDH2) in nasopharyngeal carcinoma cells Shair et al, 2009
  490. KANK2 interacts with viral BALF1 VirHostome database
  491. KAT5 – K(lysine) acetyltransferase 5 Phosphorylated by viral kinase BGLF4 Li et al, 2011
  492. KCNN4 – potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4: activated by EBV infection or antigen presentation in T cells Nicolaou et al, 2007
  493. KCTD12 interacts with viral BHRF1 VirHostome database
  494. KDSR interacts with viral BNLF2A VirHostome database
  495. KHDRBS2 interacts with viral BSLF2/BMLF1 VirHostome database
  496. KIAA0247 interacts with viral BALF1 VirHostome database
  497. KIAA0564 interacts with viral BGLF3 VirHostome database
  498. KIAA0664 interacts with viral BTRF1 VirHostome database
  499. KIAA1462 interacts with viral BVLF1 VirHostome database
  500. KIAA1598 interacts with viral BFRF0.5 VirHostome database
  501. KIAA1712 interacts with viral BFLF2 VirHostome database
  502. KIAA1967 interacts with viral EBNALP VirHostome database
  503. KIF1B interacts with viral BVLF1 VirHostome database
  504. KIRREL interacts with viral BALF1 VirHostome database
  505. KLHL12 interacts with viral BDLF2 VirHostome database
  506. KPNA1 Binds to EBNA1 Holowaty et al, 2003
  507. KPNA3 interacts with viral EBNA1 VirHostome database
  508. KPNA6 interacts with viral EBNA1 VirHostome database
  509. KPNB1 Binds to EBNA1 Holowaty et al, 2003: interacts with viral BFLF2 VirHostome database
  510. LAMA3 interacts with viral BNRF1 VirHostome database
  511. LAMC1 interacts with viral BDLF4 VirHostome database
  512. LAMP1 interacts with viral LMP2A VirHostome database
  513. LAMTOR1 interacts with viral BALF1 VirHostome database
  514. LAPTM4A interacts with viral BALF1 VirHostome database
  515. LAYN interacts with viral BALF1 VirHostome database
  516. LCK – lymphocyte-specific protein tyrosine kinase: Lck and Fyn are recruited to the tyrosine-phosphorylated Tyr112 site in LMP2A in T cells Ingham et al, 2005
  517. LDLR interacts with viral BHRF1 VirHostome database
  518. LEMD3 interacts with viral BHRF1 VirHostome database
  519. LEPRE1 interacts with viral EBNALP VirHostome database
  520. LGALS3BP interacts with viral BDLF4 VirHostome database
  521. LIFR interacts with viral BALF1 VirHostome database
  522. LLGL1 interacts with viral BVLF1 VirHostome database
  523. LMNA – lamin A/C: interacts with BGLF4 Lee et al, 2008
  524. LMO7 interacts with viral BFLF2 VirHostome database
  525. LMOD1 interacts with viral BFRF0.5 VirHostome database
  526. LNX1 interacts with viral EBNA1 VirHostome database
  527. LOX interacts with viral BALF1 VirHostome database
  528. LPP interacts with viral BFRF0.5 VirHostome database
  529. LRP10 interacts with viral BALF1 VirHostome database
  530. LRP12 interacts with viral BALF1 VirHostome database
  531. LRPPRC interacts with viral BNLF2A VirHostome database
  532. LYN – v-yes-1 Yamaguchi sarcoma viral related oncogene homolog: Viral LMP2A blocks B cell receptor (BCR) signal transduction in vitro by binding Syk and Lyn protein tyrosine kinases Caldwell et al, 1998
  533. LZTS2 interacts with viral BFLF2 VirHostome database
  534. MAGEA1 interacts with viral EBNALP VirHostome database
  535. MAGED1 interacts with viral BDLF4 VirHostome database
  536. MAGED2 interacts with viral BDLF4 VirHostome database
  537. MANF interacts with viral BDLF4 VirHostome database
  538. MAP2K1 – mitogen-activated protein kinase kinase 1:contributes to EBV latency control in lymoblastoid cells Fenton and Sinclair, 1999
  539. MAP2K3 interacts with viral BNRF1 VirHostome database
  540. MAP3K1 – mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase: EBNA1 binds close to the transcriptional start sites of cellular genes, including HDAC3, CDC7, and MAP3K1, which are positively regulated by EBNA1 Lu et al, 2010.
  541. MAP3K7 mitogen-activated protein kinase kinase kinase 7 (tak1): LMP1 uses two distinct pathways to activate NF-kappaB: via TRAF6/MAP3K7/IKBKB or TRAF3/MAP3K14/CHUK (noncanonical pathway) Wu et al, 2006.
  542. MAP3K8 – mitogen-activated protein kinase kinase kinase 8: LMP1 promotes the activation of MPA3K8, and an inactive MAP3K8 mutant suppresses LMP1-induced NF-kappaB signaling Eliopoulos et al, 2002
  543. MAP3K14 – mitogen-activated protein kinase kinase kinase 14 (nik): LMP1 uses two distinct pathways to activate NF-kappaB: via TRAF6/MAP3K7/IKBKB or TRAF3/MAP3K14/CHUK (noncanonical pathway) Wu et al, 2006.
  544. MAP4 interacts with viral BXLF1 VirHostome database
  545. MAP7D1 interacts with viral BFLF2 VirHostome database
  546. MAPK1 – mitogen-activated protein kinase 1: activated by viral LMP1 signalling Roberts and Cooper, 1998
  547. MAPK8 – mitogen-activated protein kinase 8 (JNK) Viral LMP1 stimulates Cdc42-dependent filopodia formation as well as JNK and NF(kappa)B activation in fibroblasts Puls et al, 1999
  548. MARCKS interacts with viral BDLF3.5 VirHostome database
  549. MARCKSL1 interacts with viral BHRF1 VirHostome database
  550. MARCO interacts with viral BHRF1 VirHostome database
  551. MARS interacts with viral BFLF2 VirHostome database
  552. MAVS interacts with viral BHRF1 VirHostome database
  553. MBOAT7 interacts with viral BALF1 VirHostome database
  554. MCM4 – minichromosome maintenance complex component 4: EBV-encoded protein kinasephosphorylates MCM4 and MCM6 Kudoh et al, 2006
  555. MDFI interacts with viral BFLF2 VirHostome database
  556. MDM2 – MDM2 oncogene, E3 ubiquitin protein ligase: EBNA3C deubiquitinates Mdm2 Saha et al, 2009
  557. MED4 interacts with viral BRRF1 VirHostome database
  558. MERTK – c-mer proto-oncogene tyrosine kinase: induced by Epstein-Barr virus immediate-early protein BRLF1 Li et al, 2004
  559. MET – met proto-oncogene (hepatocyte growth factor receptor): Induced by viral LMP1 in Madin-Darby canine kidney epithelial cells Horikawa et al, 2001.
  560. MFSD10 interacts with viral BNLF2A VirHostome database
  561. MGST1 interacts with viral BNLF2A VirHostome database
  562. MICAL2 interacts with viral BNLF2B VirHostome database
  563. MID2 interacts with viral BALF4 VirHostome database
  564. MIPOL1 interacts with viral BALF2 VirHostome database
  565. MIR146A – microRNA 146a: induced by LMP1 Cameron et al, 2008
  566. MIR155 – microRNA 155: transactivated by EBNA1 via NFKB signalling Gatto et al, 2008
  567. MIR200B – microRNA 200b: MIR200B and MIR429 regulate the Epstein-Barr virus latent/lytic switch Ellis-Connell et al, 2010
  568. MIR429 – microRNA 429: MIR200B and MIR429 regulate the Epstein-Barr virus latent/lytic switch Ellis-Connell et al, 2010
  569. MKRN1 interacts with viral BVLF1 VirHostome database
  570. MKRN3 interacts with viral BALF4 VirHostome database
  571. MLF2 interacts with viral EBNALP VirHostome database
  572. MLH1 – mutL homolog 1, colon cancer, nonpolyposis type 2: MSH2, MSH6, MLH1, and PMS2 can be assembled to Epstein-Barr virus replication compartments, the sites of viral DNA synthesis. Daikoku et al, 2006
  573. MMP3 upregulated by the virus in epithelial cells Lan et al, 2013
  574. MMP9 upregulated by the virus in epithelial cells Lan et al, 2013
  575. MMP14 interacts with viral BALF1 VirHostome database
  576. MON2 interacts with viral BNLF2A VirHostome database
  577. MPZL1 interacts with viral BALF1 VirHostome database
  578. MRC2 interacts with viral BDLF4 VirHostome database
  579. MRGPRF interacts with viral BNLF2A VirHostome database
  580. MRPS22 interacts with viral BXLF1 VirHostome database
  581. MSH2 – mutS homolog 2, colon cancer, nonpolyposis type 1: MSH2, MSH6, MLH1, and PMS2 can be assembled to Epstein-Barr virus replication compartments, the sites of viral DNA synthesis. Daikoku et al, 2006
  582. MST1R – macrophage stimulating 1 receptor (c-met-related tyrosine kinase)(RON) : LMP1 stimulates NFKB1 binding to the RON promoter inducing expression of RON Chou et al, 2007
  583. MTCH2 interacts with viral BDLF3.5 VirHostome database
  584. MTHFD1L interacts with viral BXLF1 VirHostome database
  585. MTOR – mechanistic target of rapamycin (serine/threonine kinase): activated by expression of LMP2A in carcinoma cells leading to inhibition of the negative regulator of translation, EIF4EBP1, and increased c-Myc protein translation Moody et al, 2005
  586. MTUS2 interacts with viral BFLF2 VirHostome database
  587. MXRA8 interacts with viral BHRF1 VirHostome database
  588. MYB – v-myb myeloblastosis viral oncogene homolog (avian): interacts synergistically with viral BZLF1 transactivator in lymphoid cells Kenney et al, 1992.
  589. MYC binds to EBNA-3B Bajaj et al, 2008
  590. MYD88 – myeloid differentiation primary response 88; suppression of EBV replication is dependent on TLR9 and MyD88 signaling in Burkitt's lymphoma cells Zauner et al, 2010
  591. MYH2 myosin, heavy chain 2, skeletal muscle, adult; interacts with viral BDLF4 VirHostome database
  592. MYLK myosin light chain kinase\; interacts with viral BNLF2A VirHostome database
  593. MYO9B interacts with viral BDLF4 VirHostome database
  594. MYOF interacts with viral BALF1 VirHostome database
  595. NAALADL2 interacts with viral BFLF2 VirHostome database
  596. NACA interacts with viral BFRF0.5 VirHostome database
  597. NAGK interacts with viral BXLF1 VirHostome database
  598. Nanoparticle-exposure of human cells latently infected with Epstein-Barr-Virus induces virus production Sattler et al, 2017.
  599. NAP1L4 Binds to EBNA1 Holowaty et al, 2003
  600. NAV1 interacts with viral BDLF4 VirHostome database
  601. NCEH1 interacts with viral BNLF2A VirHostome database
  602. NCKAP5L interacts with viral BVLF1 VirHostome database
  603. NCOR1 – nuclear receptor corepressor 1:EBV nuclear antigen LP (EBNALP) associates with NCoR and dismissed NCoR, NCoR and RBPJ, or NCoR, RBPJ, and EBNA2 from matrix-associated deacetylase bodies. EBNALP associates with hairy and enhancer of split 1 (hes1), cd21, cd23, and arginine and glutamate-rich 1 (arglu1) enhancer or promoter DNA Portal et al, 2011
  604. NCOR2 – nuclear receptor corepressor 2: see above Portal et al, 2011
  605. NDC80 interacts with viral LF2 VirHostome database
  606. NDE1 interacts with viral BHRF1 VirHostome database
  607. NDEL1 interacts with viral BHRF1 VirHostome database
  608. NDFIP1 interacts with viral BALF1 VirHostome database
  609. NDUFA4 interacts with viral BALF1 VirHostome database
  610. NECAB2 interacts with viral BALF4 VirHostome database
  611. NEDD4 interacts with viral LMP2A VirHostome database
  612. NEDD4L interacts with viral LMP2A VirHostome database
  613. NEDD8 neural precursor cell expressed, developmentally down-regulated 8 : viral BPLF1 hydrolyses NEDD8 conjugates in vitro Gastaldello et al, 2010
  614. NEFL interacts with viral BALF2 VirHostome database
  615. NFKB1 – nuclear factor of kappa light polypeptide gene enhancer in B-cells 1: Viral LMP1 induces formation of NFKB complexes containing NFkB1, NFkB2, RelA and c-Rel in human T-lymphoid and monocytic cells Chien and Hammarskjöld, 2000
  616. NFKB2 – nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100): Viral LMP1 induces formation of NFKB complexes containing NFkB1, NFkB2, RelA and c-Rel in human T-lymphoid and monocytic cells Chien and Hammarskjöld, 2000
  617. NISCH interacts with viral BFRF0.5 VirHostome database
  618. NME1 – NME/NM23 nucleoside diphosphate kinase 1: EBNA1 upregulates proteins affecting metastatic potential (stathmin 1, maspin (SERPINB5) , and NME1) in nasopharyngeal carcinoma cells Cao et al, 2012
  619. NME3 interacts with viral BHRF1 VirHostome database
  620. NOS2 – nitric oxide synthase 2, inducible: LMP1 triggers the expression of inducible nitric oxide synthase (iNOS) in Balb/3T3 fibroblasts Yu et al, 2002
  621. NOTCH1 – notch 1: LMP2A constitutively activates the Notch1 pathway to autoregulate the LMP2A promoter Anderson and Longnecker, 2009
  622. NOTCH2 interacts with viral BALF1 VirHostome database
  623. NOTCH3 interacts with viral BDLF4 VirHostome database
  624. NOTCH4 The viral RK-BARF0 protein interacts with the Notch4 ligand binding domain Kusano and Raab-Traub, 2001
  625. NOX1 – NADPH oxidase 1: EBNA1 upregulates oxidative stress response proteins SOD1 and peroxiredoxin 1 (Prx1),NOX1 and NOX2 in nasopharyngeal carcinoma cells Cao et al, 2012
  626. CYBB – cytochrome b-245, beta polypeptide (nox2) See above Cao et al, 2012
  627. NPC2 interacts with viral BNLF2B VirHostome database
  628. NPEPPS interacts with viral BNLF2A VirHostome database
  629. NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin): interacts with viral EBNA1 Malik-Soni and Frappier, 2012
  630. NR3C1 – nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor): Glucocorticoids activate Epstein Barr virus lytic replication in cells expressing NR3C1 Yang et al, 2010
  631. NR4A1 – nuclear receptor subfamily 4, group A, member 1 (nurr77): EBNA2 binds to Nur77 Lee et al, 2002
  632. NRP1 neuropilin 1: entry factor in nasopharyngeal epithelial cells Wang et al, 2015
  633. NRP2 neuropilin2: impairs infection in nasopharyngeal epithelial cells Wang et al, 2015
  634. NUP62 binds to viral kinase BGLF4 Chang et al, 2012
  635. NUP153 binds to viral kinase BGLF4 Chang et al, 2012
  636. NUP214 – nucleoporin 214kDa: involved in EB2-dependent nuclear export of RNA Farjot et al, 2000
  637. OCIAD1 interacts with viral BHRF1 VirHostome database
  638. OPTN interacts with viral BBRF2 VirHostome database
  639. OSMR interacts with viral BALF1 VirHostome database
  640. OSTC interacts with viral BDLF4 VirHostome database
  641. OSTM1 interacts with viral BALF1 VirHostome database
  642. P4HA1 prolyl 4-hydroxylase, alpha polypeptide I: interacts with viral EBNALP VirHostome database
  643. P4HA2 interacts with viral EBNALP VirHostome database
  644. P4HA3 interacts with viral EBNALP VirHostome database
  645. P4HB prolyl 4-hydroxylase, beta polypeptide: interacts with viral BALF1 VirHostome database
  646. PACS1 phosphofurin acidic cluster sorting protein 1 binds to viral protein BBLF1 Chiu et al, 2012
  647. PALLD palladin, cytoskeletal associated protein: interacts with viral BVLF1 VirHostome database
  648. PALM paralemmin: interacts with viral BALF1 VirHostome database
  649. PARP1 – poly (ADP-ribose) polymerase 1: cells treated with LMP1 siRNA showed enhanced cleavage of caspase3 and PARP Mei et al, 2007
  650. PAX5 paired box 5: binds to the latent membrane protein control region Arvey et al, 2012
  651. PBXIP1 interacts with viral BALF1 VirHostome database
  652. PCDHGB5 interacts with viral BDLF4 VirHostome database
  653. PCNA interacts with viral BDLF4 VirHostome database
  654. PCOLCE interacts with viral BDLF4 VirHostome database
  655. PDCD6IP interacts with viral BALF1 VirHostome database
  656. PDE4DIP interacts with viral BFLF2 VirHostome database
  657. PDGFRB interacts with viral BALF1 VirHostome database
  658. PDIA3 interacts with viral BHRF1 VirHostome database
  659. PDIA4 interacts with viral BGLF3 VirHostome database
  660. PDLIM4 interacts with viral BALF1 VirHostome database
  661. PDLIM5 interacts with viral BDLF4 VirHostome database
  662. PDLIM7 interacts with viral BDLF4 VirHostome database
  663. PDXDC1 interacts with viral BALF1 VirHostome database
  664. PEX14 interacts with viral BDLF4 VirHostome database
  665. PEX19 interacts with viral BVLF1 VirHostome database
  666. PFDN1 interacts with viral BFRF0.5 VirHostome database
  667. PFDN2 interacts with viral BFRF0.5 VirHostome database
  668. PFKL interacts with viral BDLF4 VirHostome database
  669. PFKP interacts with viral BDLF4 VirHostome database
  670. PFN2 interacts with viral BFLF2 VirHostome database
  671. PGRMC1 interacts with viral BALF1 VirHostome database
  672. PGRMC2 interacts with viral BALF1 VirHostome database
  673. PHB2 interacts with viral LMP2A VirHostome database
  674. PHLDB2 interacts with viral BALF1 VirHostome database
  675. PI4K2A interacts with viral BNLF2A VirHostome database
  676. PIGT interacts with viral BNLF2A VirHostome database
  677. PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha): Induced by EBNA2 in human B-lymphoblastoid cell line Spender et al, 2006
  678. PIK3R3 – phosphoinositide-3-kinase, regulatory subunit 3 (gamma): Induced by EBNA2 in human B-lymphoblastoid cell line Spender et al, 2006
  679. PIN1 – peptidylprolyl cis/trans isomerase, NIMA-interacting 1: interacts with the viral DNA polymerase catalytic subunit and regulates viral DNA replication Narita et al, 2013.
  680. PITPNM3 interacts with viral BNLF2B VirHostome database
  681. PJA2 interacts with viral BDLF4 VirHostome database
  682. PKD2 interacts with viral BNLF2A VirHostome database
  683. PLA2G4A – phospholipase A2, group IVA (cytosolic, calcium-dependent): Involved in viral reactivation Maas et al, 2006
  684. PLAU – plasminogen activator, urokinase: PAI-1, PLAU and ets1 upregulated during transformation of Madin-Darby canine kidney epithelial cells by LMP1 Kim et al, 2000
  685. PLD3 interacts with viral BFLF2 VirHostome database
  686. PLEKHA5 interacts with viral BGLF3 VirHostome database
  687. PLCG2 – phospholipase C, gamma 2 (phosphatidylinositol-specific): LMP2Astimulated protein tyrosine kinases and induced PLCG2-mediated Ca2+ oscillations followed by activation of the extracellular signal-regulated kinase (Erk) mitogen-activated protein kinase pathway in LMP2A expressing B cells Engels et al, 2012
  688. PLOD1 interacts with viral BDLF4 VirHostome database
  689. PLOD2 interacts with viral BALF1 VirHostome database
  690. PLXDC2 interacts with viral BNLF2A VirHostome database
  691. PLXNB2 interacts with viral BALF1 VirHostome database
  692. PMAIP1 – phorbol-12-myristate-13-acetate-induced protein 1: (noxa): Latent Epstein-Barr virus can inhibit apoptosis in B cells by blocking PMAIP1 induction Yee et al, 2011.
  693. PML promyelocytic leukemia: Binds to EBNA1 Sivachandran N (2008)
  694. PMS2 PMS2 postmeiotic segregation increased 2: MSH2, MSH6, MLH1, and PMS2 can be assembled to Epstein-Barr virus replication compartments, the sites of viral DNA synthesis. Daikoku et al, 2006
  695. PNKD interacts with viral BHRF1 VirHostome database
  696. PNMA1 interacts with viral BBRF2 VirHostome database
  697. PNPLA6 interacts with viral BALF1 VirHostome database
  698. POGZ interacts with viral BZLF1 VirHostome database
  699. POLN polymerase (DNA) nu : Viral BPLF1 deubiquitinates PCNA and Attenuates POLN Recruitment to DNA Damage Sites Whitehurst et al, 2012
  700. POMC – proopiomelanocortin: adrenocorticotropin enhances the lytic replication of the HR-1 strain of EBV in superinfected cells Glaser et al, 1995
  701. PON2 interacts with viral BDLF4 VirHostome database
  702. POP1 interacts with viral BFRF0.5 VirHostome database
  703. POU2F1 – POU class 2 homeobox 1: interacts with the Epstein-Barr virus BRLF1 protein to promote disruption of viral latency Robinson et al, 2011
  704. POU2F2 POU class 2 homeobox 2: promotes Epstein-Barr virus latency by inhibiting the viral immediate-early protein, BZLF1 Robinson et al, 2012.
  705. PPAPDC2 interacts with viral BDLF4 VirHostome database
  706. PPFIA1 interacts with viral BALF1 VirHostome database
  707. PPM1A interacts with viral BVLF1 VirHostome database
  708. PPM1B interacts with viral BALF1 VirHostome database
  709. PPP1CA interacts with viral BTRF1 VirHostome database
  710. PPP1R15A – protein phosphatase 1, regulatory subunit 15A (gadd34) EBNA3C interacts with Gadd34 and counteracts the unfolded protein response Garrido et al, 2009.
  711. PPP2R1A interacts with viral BDLF4 VirHostome database
  712. PPP2R2A interacts with viral BFRF0.5 VirHostome database
  713. PPP6R1 interacts with viral BDLF4 VirHostome database
  714. PPP6R3 interacts with viral BDLF4 VirHostome database
  715. PRAF2 interacts with viral BALF1 VirHostome database
  716. PREB interacts with viral BHRF1 VirHostome database
  717. PRKACA interacts with viral BNLF2B VirHostome database
  718. PRKACB interacts with viral BNLF2B VirHostome database
  719. PRKAR1A interacts with viral BDLF4 VirHostome database
  720. PRKCDBP interacts with viral BNLF2B VirHostome database
  721. PRKDC – protein kinase, DNA-activated, catalytic polypeptide: Associates with EBNA-LP Han et al, 2001
  722. PRMT1 interacts with viral BFLF2 VirHostome database
  723. PROCR interacts with viral BHRF1 VirHostome database
  724. PRPF39 interacts with viral EBNALP VirHostome database
  725. PRRC2C interacts with viral BGLF3 VirHostome database
  726. PSMA1 interacts with viral BTRF1 VirHostome database
  727. PSMA2 interacts with viral LMP2A VirHostome database
  728. PSMA3 interacts with viral LMP2A VirHostome database
  729. PSMA4 interacts with viral BVLF1 VirHostome database
  730. PSMA5 interacts with viral BVLF1 VirHostome database
  731. PSMA6 interacts with viral BTRF1 VirHostome database
  732. PSMA7 interacts with viral BVLF1 VirHostome database
  733. PSMB1 interacts with viral BVLF1 VirHostome database
  734. PSMB2 interacts with viral BTRF1 VirHostome database
  735. PSMB3 interacts with viral LMP2A VirHostome database
  736. PSMB4 interacts with viral BVLF1 VirHostome database
  737. PSMB5 interacts with viral LMP2A VirHostome database
  738. PSMB6 interacts with viral LMP2A VirHostome database
  739. PSMB7 interacts with viral LMP2A VirHostome database
  740. PSMB8 interacts with viral LMP2A VirHostome database
  741. PSMB9 interacts with viral LMP2A VirHostome database
  742. PSMC1 interacts with viral BALF1 VirHostome database
  743. PSMC2 interacts with viral BTRF1 VirHostome database
  744. PSMC3 interacts with viral BDLF4 VirHostome database
  745. PSMC4 interacts with viral BALF1 VirHostome database
  746. PSMC5 interacts with viral BTRF1 VirHostome database
  747. PSMC6 interacts with viral BVLF1 VirHostome database
  748. PSMD1 interacts with viral BALF1 VirHostome database
  749. PSMD11 interacts with viral BVLF1 VirHostome database
  750. PSMD12 interacts with viral BVLF1 VirHostome database
  751. PSMD13 interacts with viral BTRF1 VirHostome database
  752. PSMD14 interacts with viral BDLF4 VirHostome database
  753. PSMD3 interacts with viral BDLF4 VirHostome database
  754. PSMD4 interacts with viral BALF1 VirHostome database
  755. PSMD6 interacts with viral LMP2A VirHostome database
  756. PSMD7 interacts with viral BVLF1 VirHostome database
  757. PSMD8 interacts with viral BVLF1 VirHostome database
  758. PSME1 interacts with viral LMP2A VirHostome database
  759. PSME2 interacts with viral LMP2A VirHostome database
  760. PSME3 interacts with viral LMP2A VirHostome database
  761. PSME4 interacts with viral LMP2A VirHostome database
  762. PSMG1 interacts with viral LMP2A VirHostome database
  763. PTBP1 interacts with viral BBRF2 VirHostome database
  764. PTEN – phosphatase and tensin homolog: Activation of DNA methyltransferase 1 by LMP2A leads to promoter hypermethylation of PTEN gene in gastric carcinoma Hino et al, 2009.
  765. PTGS2 – prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase): Induced by LMP1 in nasopharyngeal epithelial cells Murono et al, 2001
  766. PTK7 interacts with viral BALF1 VirHostome database
  767. PTMA – prothymosin, alpha: A complex of EBNA3C and PTMA coimmunoprecipitated with HDAC1 and HDAC2 in cell lines stably expressing EBNA3C : Knight et al 2003
  768. PTPLAD1 interacts with viral BNLF2A VirHostome database
  769. PTPN1 interacts with viral BHRF1 VirHostome database
  770. PTPRF interacts with viral BALF1 VirHostome database
  771. PTPRK interacts with viral BALF1 VirHostome database
  772. PTRF interacts with viral BFLF2 VirHostome database
  773. PTTG1IP interacts with viral BDLF4 VirHostome database
  774. PVR interacts with viral BNLF2A VirHostome database
  775. PVRL2 interacts with viral BHRF1 VirHostome database
  776. PXN interacts with viral BDLF4 VirHostome database
  777. PYCARD – PYD and CARD domain containing: Interaction between PYCARD with IFI16, but not with AIM2 or NLRP3 was detected in EBV latency cells and during EBV infection of primary human B-cells Ansari et al, 2013
  778. QPCTL interacts with viral BALF1 VirHostome database
  779. QSOX1 interacts with viral BDLF4 VirHostome database
  780. RAB18 interacts with viral BALF1 VirHostome database
  781. RAB32 interacts with viral BDLF4 VirHostome database
  782. RAB34 interacts with viral BHRF1 VirHostome database
  783. RAB3IP interacts with viral BNLF2A VirHostome database
  784. RAB5C interacts with viral BHRF1 VirHostome database
  785. RABAC1 – Rab acceptor 1 (prenylated): LMP1 interacts with PRA1 at the Golgi apparatus Liu et al, 2006
  786. RAF1 – v-raf-1 murine leukemia viral oncogene homolog 1: activated by LMP1 in epithelial cells Dawson et al, 2008
  787. RANBP2 interacts with viral BGLF3 VirHostome database
  788. RAP1A interacts with viral BHRF1 VirHostome database
  789. RARA – retinoic acid receptor, alpha: binds to BZLF1 Pfitzner et al, 1995
  790. RARB – retinoic acid receptor, beta: LMP1 induces promoter hypermethylation of RARB via up-regulation of DNA methyltransferases 1, 3a, and 3b Seo et al, 2008
  791. RB1 retinoblastoma 1: binds to EBNA-3B Knight et al, 2005
  792. RBM25 interacts with viral BFRF0.5 VirHostome database
  793. RBMS2 interacts with viral BVLF1 VirHostome database
  794. RBMX interacts with viral BSLF2/BMLF1 VirHostome database
  795. RBMY1F interacts with viral BSLF2/BMLF1 VirHostome database
  796. RBPJ – recombination signal binding protein for immunoglobulin kappa J region interacts with viral EBNA3A VirHostome database
  797. RBPMS interacts with viral BDLF4 VirHostome database
  798. RCN2 interacts with viral BALF1 VirHostome database
  799. RCN3 interacts with viral BALF1 VirHostome database
  800. RDH14 interacts with viral BNLF2A VirHostome database
  801. RECQL – RecQ protein-like (DNA helicase Q1-like): interacts with EBV OriLyt Wang et al, 2009
  802. REL – v-rel reticuloendotheliosis viral oncogene homolog (avian)(c-rel) : Viral LMP1 induces formation of NFKB complexes containing NFkB1, NFkB2, RelA and c-Rel in human T-lymphoid and monocytic cells Chien and Hammarskjöld, 2000
  803. RELA – v-rel reticuloendotheliosis viral oncogene homolog A (avian): Viral LMP1 induces formation of NFKB complexes containing NFkB1, NFkB2, RelA and c-Rel in human T-lymphoid and monocytic cells Chien and Hammarskjöld, 2000
  804. RFTN1 interacts with viral BALF1 VirHostome database
  805. RHOA – ras homolog family member A: a central component of the signalling pathway reorganising the cytoskeleton in response to viral BDLF2-BMRF2 Loesing et al, 2009.
  806. RHOT1 interacts with viral BHRF1 VirHostome database
  807. RHOT2 interacts with viral BNRF1 VirHostome database
  808. RIN1 Ras and Rab interactor 1: interacts with viral BVLF1 VirHostome database
  809. RING1 ring finger protein 1: EBNA3A and EBNA3C associate with histone deacetylases BMI1, RING1 and CtBP1 Skalska et al, 2013
  810. RINT1 interacts with viral BBRF2 VirHostome database
  811. RNF4 – ring finger protein 4: binds to viral transcription factor, Rta Yang et al, 2013;
  812. RNF11 interacts with viral BALF1 VirHostome database
  813. RNF126 interacts with viral BVLF1 VirHostome database
  814. RNF149 interacts with viral BALF1 VirHostome database
  815. RNF167 interacts with viral BNLF2A VirHostome database
  816. RNF181 interacts with viral LMP2A VirHostome database
  817. RNF219 interacts with viral BFLF2 VirHostome database
  818. RNH1 interacts with viral BDLF4 VirHostome database
  819. ROBO1 interacts with viral BHRF1 VirHostome database
  820. RP2 interacts with viral BHRF1 VirHostome database
  821. RPA1 replication protein A1, 70kDa: Binds to EBNA1 Zhang et al, 1998
  822. RPL13A interacts with viral BFLF2 VirHostome database
  823. RPL21 interacts with viral BRLF1 VirHostome database
  824. RPL22 – ribosomal protein L22: interacts with viral EBER1 Fok et al, 2006
  825. RPL28 interacts with viral EBNA1 VirHostome database
  826. RPL3 interacts with viral EBNA1 VirHostome database
  827. RPL31 interacts with viral EBNA1 VirHostome database
  828. RPL34 interacts with viral EBNA1 VirHostome database
  829. RPL35 interacts with viral EBNA1 VirHostome database
  830. RPL37A interacts with viral EBNA1 VirHostome database
  831. RPL39 interacts with viral EBNA1 VirHostome database
  832. RPN2 interacts with viral BDLF4 VirHostome database
  833. RPS3A ribosomal protein S3A Binds to EBNA5 Kashuba et al, 2005
  834. RPS13 interacts with viral EBNA1 VirHostome database
  835. RPS24 interacts with viral EBNA1 VirHostome database
  836. RPS27 interacts with viral BDLF3.5 VirHostome database
  837. RPS27L interacts with viral BDLF4 VirHostome database
  838. RPS5 interacts with viral BHRF1 VirHostome database
  839. RPS6KA3 interacts with viral BALF1 VirHostome database
  840. RPS7 interacts with viral EBNA1 VirHostome database
  841. RRAS interacts with viral BHRF1 VirHostome database
  842. RRAS2 interacts with viral BHRF1 VirHostome database
  843. RRBP1 interacts with viral BHRF1 VirHostome database
  844. RSL1D1 interacts with viral EBNA1 VirHostome database
  845. RSU1 interacts with viral BGLF3 VirHostome database
  846. RTN4 interacts with viral BDLF3.5 VirHostome database
  847. RUNX1 – runt-related transcription factor 1: suppressed by viral EBNA2 in B cells Spender et al, 2002
  848. RUNX3 – runt-related transcription factor 3: expression increased by viral EBNA2 in B cells Spender et al, 2002
  849. RUVBL2 interacts with viral BDLF4 VirHostome database
  850. RXRA – retinoid X receptor, alpha: Binds to BZLF1 Sista et al, 1995
  851. S100A10 interacts with viral BFLF2 VirHostome database
  852. S100A16 interacts with viral BNLF2A VirHostome database
  853. S100A6 interacts with viral BSRF1 VirHostome database
  854. S1PR3 interacts with viral BALF1 VirHostome database
  855. SACM1L interacts with viral BHRF1 VirHostome database
  856. SARS interacts with viral BFRF0.5 VirHostome database
  857. SCAMP2 interacts with viral BNLF2A VirHostome database
  858. SCAMP3 interacts with viral BNLF2A VirHostome database
  859. SCAMP4 interacts with viral BNLF2A VirHostome database
  860. SCARB2 interacts with viral BNLF2A VirHostome database
  861. SCCPDH interacts with viral BNLF2A VirHostome database
  862. SCFD1 interacts with viral BNLF2A VirHostome database
  863. SCO2 interacts with viral BDLF4 VirHostome database
  864. SCYL1 interacts with viral EBNALP VirHostome database
  865. SDCBP interacts with viral BALF1 VirHostome database
  866. SDCBP2 interacts with viral BALF2 VirHostome database
  867. SCIMP SLP adaptor and CSK interacting membrane protein : the viral transcription factor zta binds to the SCIMP gene Ramasubramanyan et al, 2015
  868. SDF2 – stromal cell-derived factor 2: EBV infection of tonsillar B cells increases expression (7 days post infection) Ehlin-Henriksson et al, 2009
  869. SDF4 stromal cell derived factor 4: interacts with viral BALF1 VirHostome database
  870. SDHB interacts with viral BHRF1 VirHostome database
  871. SEC16A interacts with viral BDLF4 VirHostome database
  872. SEC22B interacts with viral BDLF4 VirHostome database
  873. SEC61A1 interacts with viral BNLF2A VirHostome database
  874. SEC61B interacts with viral BALF1 VirHostome database
  875. SEC62 interacts with viral BVLF1 VirHostome database
  876. SEC63 interacts with viral BNLF2A VirHostome database
  877. SELRC1 interacts with viral BNLF2A VirHostome database
  878. SEPT9 interacts with viral BDLF4 VirHostome database
  879. SERBP1 interacts with viral BHRF1 VirHostome database
  880. SERPINB5 – serpin peptidase inhibitor, clade B (ovalbumin), member 5: EBNA1 upregulates proteins affecting metastatic potential (stathmin 1, maspin (SERPINB5) , and NME1) in nasopharyngeal carcinoma cells Cao et al, 2012
  881. SERPINB9 – serpin peptidase inhibitor, clade B (ovalbumin), member 9: In kidney transplants, serpinB9 transcription was increased during infection with cytomegalovirus, EBV or BK virus Heutinck et al, 2012 SERPINB9 is a granzyme B inhibitor (GZMB): see Classen et al, 2006
  882. SERPINE1 – serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1(PAI-1)), member 1 : PAI-1, PLAU and ets1 upregulated during transformation of Madin-Darby canine kidney epithelial cells by LMP1 Kim et al, 2000
  883. SERPINE2 interacts with viral BALF1 VirHostome database
  884. SETX interacts with viral BFRF0.5 VirHostome database
  885. SFN interacts with viral BALF4 VirHostome database
  886. SFRP1 interacts with viral EBNA1 VirHostome database
  887. SFXN3 interacts with viral BDLF4 VirHostome database
  888. SH2D1A – SH2 domain containing 1A; LMP1 suppresses this Sgene, leading to T-cell activation and enhanced Th1 cytokine secretion in response to EBV infection Chuang et al, 2005.
  889. SH3BP4 interacts with viral BDLF4 VirHostome database
  890. SH3GLB2 interacts with viral BFRF1
  891. SH3KBP1 interacts with viral BFRF0.5 VirHostome database
  892. SHB – Src homology 2 domain containing adaptor protein B : Shb binding to viral LMP2A regulates stability of the Syk tyrosine kinase in LMP2A-expressing cells Matskova et al, 2007
  893. SIAH1 interacts with viral BALF2 VirHostome database
  894. SIN3A – SIN3 transcription regulator homolog A (yeast): A complex of EBNA3C and ProThymosin alpha (PTMA) coimmunoprecipitated with HDAC1 and HDAC2 in cell lines stably expressing EBNA3C : The complex also binds SIN3A Knight et al 2003
  895. SKP2 – S-phase kinase-associated protein 2, E3 ubiquitin protein ligase :recruitment of Skp2 activity to cyclin A complexes by EBNA3C results in ubiquitination and Skp2-dependent degradation of p27 (cdkn1b) Knight et al, 2005
  896. SLAIN2 interacts with viral BALF1 VirHostome database
  897. SLC12A4 interacts with viral BALF1 VirHostome database
  898. SLC16A3 interacts with viral BSRF1 VirHostome database
  899. SLC20A1 interacts with viral BALF1 VirHostome database
  900. SLC22A18 interacts with viral BHRF1 VirHostome database
  901. SLC25A22 interacts with viral BDLF4 VirHostome database
  902. SLC26A3 interacts with viral BGLF3 VirHostome database.5
  903. SLC27A4 interacts with viral BDLF4 VirHostome database
  904. SLC2A1 interacts with viral BDLF4 VirHostome database
  905. SLC30A7 interacts with viral BHRF1 VirHostome database
  906. SLC30A9 interacts with viral BNLF2A VirHostome database
  907. SLC3A2 interacts with viral BDLF4 VirHostome database
  908. SLC7A5 interacts with viral BDLF4 VirHostome database
  909. SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1: binds to EBNA2 Kwiatkowski et al, 2004
  910. SNAP23 interacts with viral BALF1 VirHostome database
  911. SND1 interacts with viral BXLF1 VirHostome database
  912. SNW1 – SNW domain containing 1 :Binds to EBNA2 Zhou et al, 2000
  913. SNX17 interacts with viral BALF1 VirHostome database
  914. SNX3 interacts with viral BALF1 VirHostome database
  915. SOCS1 – suppressor of cytokine signaling 1: EBV infection in monocytes induced the expression of SOCS3 and, to a lesser extent, SOCS1, both known to interfere with the amplification of IFNalpha secretion mediated by the JAK/STAT signal transduction pathway Michaud et al, 2010
  916. SOCS3 – suppressor of cytokine signaling 3 See above Michaud et al, 2010
  917. SOD1 – superoxide dismutase 1, soluble: EBNA1 upregulates proteins affecting metastatic potential (stathmin 1, maspin (SERPINB5) , and Nm23-H1) and several proteins in the oxidative stress response proteins SOD1 and peroxiredoxin 1 (Prx1),NOX1 and NOX2 in nasopharyngeal carcinoma cells Cao et al, 2012
  918. SOD2 – superoxide dismutase 2, mitochondrial: upregulated by infection in B cells Jeon et al, 2008
  919. SORT1 interacts with viral BDLF4 VirHostome database
  920. SP1 transcription factor binds to the latent membrane protein control region Arvey et al, 2012
  921. SP100 nuclear antigen interacts with viral EBNALP VirHostome database
  922. SPAG5 sperm associated antigen 5; interacts with viral BNLF2B VirHostome database
  923. SPARC secreted protein, acidic, cysteine-rich (osteonectin): interacts with viral BALF1 VirHostome database
  924. SPATS2L spermatogenesis associated, serine-rich 2-like: interacts with viral EBNA1 VirHostome database
  925. SPI1 – spleen focus forming virus (SFFV) proviral integration oncogene spi1: EBNA2 increases SPI1 (pu.1)-dependent up-regulation of endogenous UCHL1 expression Bheda et al, 2011
  926. SPNS1 spinster homolog 1: interacts with viral BHRF1 VirHostome database
  927. SPPL2B signal peptide peptidase like 2B: interacts with viral BHRF1 VirHostome database
  928. SPTLC1 serine palmitoyltransferase, long chain base subunit 1: interacts with viral BDLF4 VirHostome database
  929. SPTLC2 serine palmitoyltransferase, long chain base subunit 2 : interacts with viral BDLF4 VirHostome database
  930. SQRDL sulfide quinone reductase-like (yeast): interacts with viral BALF1 VirHostome database
  931. SRC – v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian): Inhibition of FAK or its signaling mediator Src kinase inhibits LMP2A-induced migration of human foreskin keratinocytes Fotheringham et al, 2012
  932. SRGN – serglycin: Expression increased by infection in B cells Birkenbach et al, 1993
  933. SRPK1 interacts with viral EBNA1 VirHostome database
  934. SRPK2 interacts with viral EBNA1 VirHostome database
  935. SRPR interacts with viral BDLF4 VirHostome database
  936. SRPRB interacts with viral BALF1 VirHostome database
  937. SRR interacts with viral BDLF4 VirHostome database
  938. SRRM1 interacts with viral EBNA1 VirHostome database
  939. SRRM2 interacts with viral BALF1 VirHostome database
  940. SRSF1 serine/arginine-rich splicing factor 1 : Binds to EBNA1 Wang et al, 1997
  941. SSFA2 interacts with viral BGLF3.5 VirHostome database
  942. SSR4 interacts with viral BDLF4 VirHostome database
  943. SST Somatostatin enhances the lytic replication of the HR-1 strain of EBV in superinfected cells Glaser et al, 1995
  944. SSX2IP interacts with viral BXLF1 VirHostome database
  945. STAP2 – signal transducing adaptor family member 2: interacts with LMP1 and modulates LMP1-mediated NF-kappaB signaling Sekine, 2010.
  946. STAT1 signal transducer and activator of transcription 1 : expression modulated by LMP1 Najjar et al, 2005
  947. STAT2 signal transducer and activator of transcription 2 : LMP-1 prevents Tyk2 phosphorylation and inhibits IFN-alpha-stimulated STAT2 nuclear translocation and interferon-stimulated response element transcriptional activity geiger and Martin, 2006.
  948. STAT3 – signal transducer and activator of transcription 3 (acute-phase response factor) : LMP1 activates EGFR, STAT3, and ERK via PKCdelta Kung et al, 2011.
  949. EBV infection was associated with a significant increase in the tyrosine-phosphorylated forms of STAT3 and STAT5 in HeLa-Bx1 cells Chen et al, 2003
  950. STAT6 – signal transducer and activator of transcription 6, interleukin-4 induced: STAT6 binding site in the LMP-1 promoter Kis et al, 2011
  951. STAU1 interacts with viral EBNA1 VirHostome database
  952. STIM1 interacts with viral BALF1 VirHostome database
  953. STMN1 – stathmin 1 Phosphorylated by viral kinase BGLF4 Chen et al, 2010
  954. STOM interacts with viral BALF1 VirHostome database
  955. STOML2 interacts with viral BNLF2A VirHostome database
  956. STT3A interacts with viral BHRF1 VirHostome database
  957. STUB1 interacts with viral BNRF1 VirHostome database
  958. STX10 interacts with viral BNLF2A VirHostome database
  959. STX12 interacts with viral BALF1 VirHostome database
  960. STX4 interacts with viral BNLF2A VirHostome database
  961. STX7 interacts with viral BALF1 VirHostome database
  962. SUMO1small ubiquitin-like modifier 1: binds to viral kinase BGLF4 Li et al, 2012
  963. SUMO2 binds to viral kinase BGLF4 Li et al, 2012
    1. 575 members of the SUMO interactome may be targeted by one or more Epstein-Barr virus miRNAs Callegari et al, 2014
  964. SURF4 interacts with viral BALF1 VirHostome database
  965. SYK – spleen tyrosine kinase: Shb binding to viral LMP2A regulates stability of the Syk tyrosine kinase in LMP2A-expressing cells Matskova et al, 2007
  966. SYT11 interacts with viral BALF1 VirHostome database
  967. TAB1 interacts with viral BHRF1 VirHostome database
  968. TAF1A Binds to EBNA1 Holowaty et al, 2003
  969. TAF1B Binds to EBNA1 Holowaty et al, 2003
  970. TAF4 interacts with viral BRLF1 VirHostome database
  971. TAF6 interacts with viral BRLF1TAF6L interacts with viral BVLF1 VirHostome database
  972. TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)interacts with viral BNLF2A VirHostome database
  973. TAP2 the presence of TAP2 is essential for for interactions of BNLF2a with the HLA class I peptide-loading complex Horst et al, 2009
  974. TAPBP interacts with viral BNLF2A VirHostome database
  975. TAX1BP1 interacts with viral BLLF3 VirHostome database
  976. TBC1D15 interacts with viral BNLF2A VirHostome database
  977. TBC1D17 interacts with viral BNLF2A VirHostome database
  978. TBL2 interacts with viral BNLF2A VirHostome database
  979. TBX21 – T-box 21: Epstein-Barr virus-encoded miR-BART20-5p inhibits Tbx21 translation Lin et al, 2013
  980. TBXAS1 interacts with viral BSRF1 VirHostome database
  981. TCF12 binds to the latent membrane protein control region Arvey et al, 2012
  982. TCP11L1 interacts with viral BVLF1 VirHostome database
  983. TECR interacts with viral BNLF2A VirHostome database
  984. TERF1 – telomeric repeat binding factor (NIMA-interacting) 1: TERF1, TERF2, and TERF2IP modulate replication of Epstein-Barr virus OriP Deng et al, 2003.
  985. TERF2 – telomeric repeat binding factor 2: modulates replication of Epstein-Barr virus OriP Deng et al, 2003.
  986. TERF2IP – telomeric repeat binding factor 2, interacting protein: modulates replication of Epstein-Barr virus OriP Deng et al, 2003.
  987. TERT – telomerase reverse transcriptase: inhibition triggers Epstein-Barr virus lytic cycle Giunco et al, 2013
  988. TFCP2 interacts with viral BBRF2 VirHostome database
  989. TFG interacts with viral BZLF1 VirHostome database
  990. TFIP11 interacts with viral BFLF2 VirHostome database
  991. TFRC interacts with viral BALF1 VirHostome database
  992. TGFA – transforming growth factor, alph: EGFR ligands (TGFA, HBEGF and epiregulin) are constitutively induced by LMP1 in mice expressing the Cao strain of LMP1 in epithelia Charalambous et al, 2007
  993. TGFB1 – transforming growth factor, beta 1: induced EBV reactivation in epithelial cells Fukuda et al, 2001
  994. TGFB1I1 interacts with viral BDLF4 VirHostome database
  995. TGFBI interacts with viral BGLF3 VirHostome database
  996. TGFBR2 interacts with viral BALF1 VirHostome database
  997. TIMM13 interacts with viral BTRF1 VirHostome database
  998. TIMM8A interacts with viral BTRF1 VirHostome database
  999. TLK1 tousled-like kinase 1 Tousled kinases modulate Reactivation of Gammaherpesviruses from Latency Dillon et al, 2013.
  1000. TLK2 tousled-like kinase 2 Tousled kinases modulate Reactivation of Gammaherpesviruses from Latency Dillon et al, 2013.
  1001. TLR2– toll-like receptor 2: activated by EBV Gaudreault et al, 2007
  1002. TLR3 – toll-like receptor 3: activated by EBV RNA Iwakiri et al, 2009
  1003. TLR7 – toll-like receptor 7: EBV DNA and RNA promoted IFNalpha production by human Plasmacytoid dendritic cells through engagement of TLR9 and TLR7, respectively Quan et al, 2010
  1004. TLR9 – toll-like receptor 9: see above Quan et al, 2010
  1005. TM9SF1 interacts with viral BHRF1 VirHostome database
  1006. TM9SF2 interacts with viral BNLF2A VirHostome database
  1007. TM9SF3 interacts with viral BHRF1 VirHostome database
  1008. TMCO4 interacts with viral BDLF4 VirHostome database
  1009. TMEM161A interacts with viral BNLF2A VirHostome database
  1010. TMEM165 interacts with viral BDLF4 VirHostome database
  1011. TMEM175 interacts with viral BNLF2A VirHostome database
  1012. TMEM200A interacts with viral BALF1 VirHostome database
  1013. TMEM30A interacts with viral BALF1 VirHostome database
  1014. TMEM33 interacts with viral BHRF1 VirHostome database
  1015. TMEM55A interacts with viral BALF1 VirHostome database
  1016. TMEM55B interacts with viral BALF1 VirHostome database
  1017. TMEM59 interacts with viral BALF1 VirHostome database
  1018. TMPO interacts with viral BHRF1 VirHostome database
  1019. TMX1 interacts with viral BNLF2A VirHostome database
  1020. TMX3 interacts with viral BDLF4 VirHostome database
  1021. TNF inhibits actication of B cells by the virus Janssen and Kabelitz 1988
  1022. TNFAIP3 binds to viral LMP1 Fries et al, 1999
  1023. TNFRSF1A – tumor necrosis factor receptor superfamily, member 1A: Downregulated by EBNA1 in T cells Chuang et al, 2007
  1024. TNFRSF6B – tumor necrosis factor receptor superfamily, member 6b, decoy: LMP1 upregulates TNFRSF6B via NFKB1 and phosphatidylinositol 3-kinase-signaling in nasopharyngeal carcinoma cells Ho et al, 2009
  1025. TNFRSF10B interacts with viral BALF1 VirHostome database
  1026. TNFRSF10D interacts with viral BNLF2B VirHostome database
  1027. TNFSF13 tumor necrosis factor (ligand) superfamily, member 13 (APRIL) LMP1 dysregulates class switch DNA recombination by triggering aberrant BAFF and APRIL expression in B cells He et al, 2003
  1028. TNFSF13B – tumor necrosis factor (ligand) superfamily, member 13b (BAFF) See above He et al, 2003
  1029. TNIK – TRAF2 and NCK interacting kinase: required for canonical NF-kB and JNK signaling in B-cells by viral LMP1 and the CD40 receptor Shkoda et al, 2012.
  1030. TNKS1BP1 interacts with viral BDLF4 VirHostome database
  1031. TNPO1 interacts with viral BNLF2A VirHostome database
  1032. TNS3 interacts with viral BDLF4 VirHostome database
  1033. TOLLIP interacts with viral BALF1 VirHostome database
  1034. TOP1 – topoisomerase (DNA) I; binds to viral zta Wang et al, 2009
  1035. TOP2A – topoisomerase (DNA) II alpha 170kDa: BGLF4 stimulates the decatenation activity of topoisomerase II Lee et al, 2007
  1036. TOR1AIP1 interacts with viral LMP2A VirHostome database
  1037. TOR1AIP2 interacts with viral BDLF4 VirHostome database
  1038. TP53 tumor protein p53: EBNA-5 binds to the retinoblastoma and p53 proteins Szekely et al, 1993.
  1039. TP53BP1 – tumor protein p53 binding protein 1: Binds to viral zta Bailey et al, 2009
  1040. TP53I11 interacts with viral BNLF2A VirHostome database
  1041. TP73 tumor protein p73: Upregulated by viral LMP-1 Accardi,et al, 2013
  1042. TPP1 interacts with viral BDLF4 VirHostome database
  1043. TPST1 – tyrosylprotein sulfotransferase 1: induced by viral LMP1 and associated with the metastatic potential of human nasopharyngeal carcinoma Xu et al, 2013.
  1044. TRADD TNFRSF1A-associated via death domainbinds to viral LMP1 Fries et al, 1999
  1045. TRAF1 interacts with viral BALF2 :binds to viral LMP1 Fries et al, 1999
  1046. TRAF2 binds to viral LMP1 Fries et al, 1999
  1047. TRAF4 interacts with viral EBNA3B VirHostome database
  1048. TRAF6 critical for LMP1-mediated B cell activation Arcipowski et al, 2011
  1049. TRAFD1 interacts with viral BDLF4 VirHostome database
  1050. TRAM1 interacts with viral BALF1 VirHostome database
  1051. TRIM27 interacts with viral BALF4 VirHostome database
  1052. TRIM28 – tripartite motif containing 28: interacts with replication protein BBLF2/3 Liao et al, 2005
  1053. TRIM32 interacts with viral BVLF1 VirHostome database
  1054. TRIM65 interacts with viral BVLF1 VirHostome database
  1055. TRIO interacts with viral BHRF1VirHostome database
  1056. TRPV2 interacts with viral BHRF1VirHostome database
  1057. TSHZ3 interacts with viral BDLF4 VirHostome database
  1058. TTC12 interacts with viral BBRF2 VirHostome database
  1059. TTC38 interacts with viral BTRF1 VirHostome database
  1060. TUBGCP6 interacts with viral BFRF0.5 VirHostome database
  1061. TYK2 – tyrosine kinase 2: Viral LMP1 negatively affects Tyk2 phosphorylation and interferon signaling in human B cells Geiger and Martin, 2006.
  1062. UBAC2 interacts with viral LMP2A VirHostome database
  1063. UBASH3B interacts with viral LMP2A VirHostome database
  1064. UBB ubiquitin B: See below Sompallae et al, 2008
  1065. UBC ubiquitin C: The virus et al, encodes three ubiquitin-specific proteases capable of hydrolysing ubiquitin .Sompallae et al, 2008
  1066. UBE2I interacts with viral BSLF2/BMLF1 VirHostome database
  1067. UBL4A interacts with viral BVLF1 VirHostome database
  1068. UBQLN1 interacts with viral LMP1 VirHostome database
  1069. UBR4 interacts with viral BFRF0.5 VirHostome database
  1070. UBR5 interacts with viral BALF1 VirHostome database
  1071. UCHL1 – ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase): EBNA2 increases SPI1 (pu.1)-dependent up-regulation of endogenous UCHL1 expression Bheda et al, 2011
  1072. UCHL5 interacts with viral BVLF1 VirHostome database
  1073. UGCG UDP-glucose ceramide glucosyltransferase; interacts with viral LMP2A VirHostome database
  1074. UGDH – UDP-glucose 6-dehydrogenase: Upregulated by LMP2A in HEK293 cells Pan et al, 2008
  1075. UGGT2 interacts with viral BTRF1 VirHostome database
  1076. UNC93B1 interacts with viral BNLF2A VirHostome database
  1077. UPF1 interacts with viral EBNA1 VirHostome database
  1078. USHBP1 interacts with viral BALF2 VirHostome database
  1079. USMG5 interacts with viral BDLF4 VirHostome database
  1080. USO1 interacts with viral BDLF4 VirHostome database
  1081. USP7 ubiquitin specific peptidase 7 (herpes virus-associated): Binds to EBNA1 Holowaty et al, 2003
  1082. USP47 interacts with viral BDLF4 VirHostome database
  1083. USP9X interacts with viral BRLF1 VirHostome database
  1084. UXT – ubiquitously-expressed, prefoldin-like chaperone: phosphorylated by viral kinase BGLF4 Chang et al, 2012
  1085. VAMP5 interacts with viral BNLF2A VirHostome database
  1086. VAMP7 interacts with viral BALF1 VirHostome database
  1087. VAPA interacts with viral BHRF1 VirHostome database
  1088. VARS interacts with viral BFRF0.5 VirHostome database
  1089. VAT1 interacts with viral BNLF2A VirHostome database
  1090. VAV1 – vav 1 guanine nucleotide exchange factor: LMP2 is constitutively tyrosine phosphorylated and associated with Lyn and Syk tyrosine kinases . Baseline Lyn activity is reduced, and slg cross-linking fails to activate Lyn, Syk, Pl3-K, PLC gamma 2, Vav, Shc, and MAPK. Syk, Pl3-K, PLC gamma 2, and Vav are constitutively tyrosine phosphorylated Miller at al, 1995
  1091. VDAC1 – voltage-dependent anion channel 1 (porin): Involved in LMP1 signalling Yan et al, 2006
  1092. VDR Vitamin D (1,25- dihydroxyvitamin D3) receptor: binds to EBNA3 Yenamandra et al, 2010
  1093. VEGFA – vascular endothelial growth factor A: Induced by LMP1 in nasopharyngeal epithelial cells Murono et al, 2001
  1094. VHL – von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase: EBV infection of tonsillar B cells reduces expression (7 days post infection) Ehlin-Henriksson et al, 2009
  1095. VIM vimentin modulated by LMP1 in lipid rafts Meckes et al, 2013
  1096. VKORC1 vitamin K epoxide reductase complex, subunit 1interacts with viral BDLF3.5 VirHostome database
  1097. VPS11 interacts with viral BXLF1 VirHostome database
  1098. WLS interacts with viral BNLF2A VirHostome database
  1099. WNT5A interacts with viral BDLF4 VirHostome database
  1100. WRB – tryptophan rich basic protein: BNLF2a acts as a tail-anchored protein, exploiting AASNA1/WRB for posttranslational insertion into the endoplasmic reticulum membrane, where it blocks antigen translocation by the transporter associated with antigen processing (TAP) Wycisk et al, 2011
  1101. WWOX interacts with viral BNLF2A VirHostome database
  1102. WWP1 interacts with viral LMP2A VirHostome database
  1103. WWP2 – WW domain containing E3 ubiquitin protein ligase 2: interacts with viral BALF1 VirHostome database
  1104. XBP1 – X-box binding protein 1: LMP1 activates PERK, ERN1 and ATF6, resulting in increased XBP1 splicing Lee and Sugden, 2006.
  1105. XPC xeroderma pigmentosum, complementation group C: interacts with BGLF4 Lu et al, 2007
  1106. XPO1 – exportin 1 (CRM1 homolog, yeast) interacts with viral BNLF2A VirHostome database
  1107. XPO7 – exportin 7: interacts with viral BNLF2A VirHostome database
  1108. XRCC5 – X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining): binds to Zta on Zta-response elements in the BHLF1 promoter Chen et al, 2011
  1109. YEATS2 interacts with viral BVLF1 VirHostome database
  1110. YPEL5 interacts with viral BXLF1 VirHostome database
  1111. YWHAH interacts with viral BALF1 VirHostome database
  1112. YWHAZ – tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide: Involved in viral reactivation Maas et al, 2006
  1113. ZAK interacts with viral BDLF4 VirHostome database
  1114. ZBED1 interacts with viral BFLF2 VirHostome database
  1115. ZBP1 – Z-DNA binding protein 1binds to viral eber1 Clarke et al, 1991;
  1116. ZDHHC17 zinc finger, DHHC-type containing 17; interacts with viral BSRF1 VirHostome database
  1117. ZEB1 zinc finger E-box binding homeobox 1; regulates the latent-lytic switch in infection by Epstein-Barr virus Yu et al, 2007.
  1118. ZEB2 – zinc finger E-box binding homeobox 2: ZEB1 or ZEB2 regulate the Epstein-Barr virus latent-lytic switch in a cell-type-specific manner Ellis et al, 2010.
  1119. ZFPL1 zinc finger protein-like 1; interacts with viral BVLF1 VirHostome database
  1120. ZMYND11 zinc finger, MYND-type containing 11: Binds to LMP1 Ikeda et al, 2010
  1121. ZNF250 interacts with viral BALF2 VirHostome database
  1122. ZNF350 – zinc finger protein 350: interacts with replication protein BBLF2/3 Liao et al, 2005
  1123. ZW10 zw10 kinetochore protein: interacts with viral BNLF2A VirHostome database
  1124. ZYX Zyxin interacts with viral BVLF1 VirHostome database Microarray and bulk experiments

Identification of Epstein-Barr virus (EBV) nuclear antigen 2 (EBNA2) target proteins by proteome analysis: activation of EBNA2 in conditionally immortalized B cells reflects early events after infection of primary B cells by EBV. Shlee et al 2004

Proteins induced by infection: ACTG1 ANXA4 ARHGDIB BID CAPZB CDV3 EIF5A GSTP1 NME1 PPA1 PRDX3 PSME3 TPT1 TXN UCHL3

Role of NF-KB in Cell Survival and Transcription of Latent Membrane Protein 1-Expressing or Epstein-Barr Virus Latency III-Infected Cells Cahir-McFarland et al, 2004 (lymphoblastoid cell lines) Genes that change > 4-fold with EBV infection or LMP1 expression.

EBV-induced genes; CCL3 CCND2 CCR7 CD21 CD23A CD39 CD44 CD58 CD62L CD95 CHI3L2 CYB5 DEC1 DENND2D DNASE1L3 DOK1 DUSP5 FCGR2 FGFR2 GBE1 GPR183 GPX1 GSTM1 GSTM2 IFNGR1 IL16 IL2RB IL32 IRF4 LGALS1 LGMN LILRB4 LOC125914 LY6E MARCKS MDFIC MT2A MX1 PPP2R2B PRKCB PTPN6 RAB22B RAB27A RASSF7 RGS1 S1PR1 SAMSN1 SKAP1 SLAMF1 SP100 STAT1 TFAP4 TIMP1 TNFAIP3 TRAF1 TRIM22 VIM

EBV repressed genes: ATP2A3 BZW2 CCND3 CD10 CD52 CD79B CXCR5 LRMP MEF2B MYBL2 PRKAR2B RGS13 SLC2A5 TCL1A VPREB3 YWHAA

LMP1 induced genes: BCL2A1 BIRC3 CCL17 CCL3 CCL4 CCL5 CCR7 CD40 CD54 CD58 CD83 CD95 CFLAR CXCL10 EBI3 FGFR2 IL16 IL32 IRF4 NFKBIA NFKBIE PLEK RGS1 SAMSN1 SGK1 SLAMF1 STST1 TAP1 TNFAIP3 TNFRSF14 TRAF1 TRIP10

Virus and Cell RNAs Expressed during Epstein-Barr Virus Replication Yuan et al, 2006

RNAs differentially increased in EBV+ Akata cells at 4 or 8 h APLP2 ARHQ ASNS C14orf130 C6orf80 C8FW CAST CD22 CD24 CD72 CD83 DC12 DUSP5 EGR1 EVI2A EVI2B FLJ1127 FUT8 HLADGB1orB2 HLA-DRB3 HSD17B12 ID2 IL21R INSIG1 KIAA0907 KIAA1076 LLTI LRMP M6PR MAP2K1 MAP2K6 MAPRE2 MEF2C MGC3222 MS4A1 NFATC1 NFKBIA NOS1 ODAG PLEK PMM2 PP3CC PRDM10 PRG1 PRNP PTPN6 RCP SERPINB1 SERPINB9 SGK SIAH2 SLC39A8 SLC7A1 SNIP1 SQSTM1 STAT3 TCF20 TMPO TNFAIP3 TPM4 TRAF1 TRIM38 UGCG WARS WBSCR5

RNAs Increased in abundance in EBV+ Akata cell relative to EBV- Akata cells at 24 to 48 h CD22 CD72 CD83 DUSP5 IF135 IFIT4. IL21R INSIG1 LRMP M6PR MS4A1 MX2 NFKBIA OASL PHF11 PLEK PTPN6 SGK STAT3 TCF20 TNFAIP3 TRAF1 WBSCR5

 

down-regulated in IgG cross-linked EBV+ Akata cells versus EBV- Akata cells from 4 or 8 h until 12, 24, or 48 h

BTG2 C5orf13 DLEU1 E2F1 ELL3 FADS3 FCGR21 IF135 IFIT4 IL10RA ISG20 KCNN3 LOC51337 MAP2K5 MX2 NPTX2 OAS1 OAS2 OASL PEX7 PHF11 PR48 RGS16 RIMS3 SP110 STXB6 VPREB3 Genome-wide analysis of host-chromosome binding sites for Epstein-Barr Virus Nuclear Antigen 1 (EBNA1) Lu et al, 2010.

Activated by EBNA1: CDC7, HDAC3, MAP3K1, MYO1C, TFEB, and PBX2

EBNA1 depletion reduces expression of several genes including HDAC3, MAP3K1, SIVA1, MYO1C, PBX2, NIN , WASF2, and MDK

Epstein-Barr virus nuclear antigen 3C regulated genes in lymphoblastoid cell lines. Zhao et al, 2011

EBNA3C and EBNA3A up-regulated: CCL5 CD24 CST3 DDX60 DMD GAS7 GNPTAB IFI27 IFI6 IFIT1 IL17RB KCNN3 LGALS8 LTA MNDA OAS1 OAS3 RAB13 S100A4 S100A6 STAG3 TMEM45A TNF TNFAIP2 XAF1

ASAH1 ASCL1 CCL5 CDH1 CETP CR2 CRIP1 CXCR4 ENO2 ITGB2 LBH MAFF MAP3K8 MYLIP NCF1C NR3C1 OAS3 PTPRC RGS1 TRAC ZBTB32

EBNA3C up-regulated and EBNA3A down-regulated, : CDH1 CXCR4 KIAA1659 NMT2 PTPN13 RAI14

ABCG1 AICDA ALOX5AP AMMECR1 ARHGAP25 ASAH1 ASCL1 ATRX BCL2L11 CCL5 CD24 CD27 CD47 CDH1 CETP CNN3 CR2 CRIP1 CXCR4 DNMBP ENO2 FNBP1 GAS7 HLA-DQB1 IGJ IRF4 ITGA4 ITGB2 JAK1 KCNN3 KTN1 LBH LYN MAFF MAGT1 MAP3K8 MYLIP NCF1C NR3C1 OAS1 OAS3 P2RX5 PKIG POU2F2 PTPRC RAPGEF2 RGS1 SACS SELL SLC1A4 TRAC TRIM14 EBNA3C and EBNA3A down-regulated: ANKMY2 ARHGAP25 BZW2 CITED2 FOXO1 GIMAP5 GIMAP6 IGJ IL18R1 JAK1 MED13L MTUS1 SLC1A4 TRIB1 TXNDC5

IGJ POU2F2 SACS

EBNA3C down-regulated and EBNA3A up-regulated CHST12 RB1 SELL SYNE2 ZNF83

AMMECR1 ARHGAP25 ATRX BCL2L11 CD27 CD47 DNMBP FNBP1 IRF4 ITGA4 JAK1 KTN1 LYN MAGT1 P2RX5 RAPGEF2 SELL SLC1A4 WNK1 ZNF638

Conserved Herpesvirus Kinases Target the DNA Damage Response Pathway and TIP60 Histone Acetyltransferase to Promote Virus Replication Li et al, 2011

Substrates of the viral BGLF4 kinase:- AAK1 ACOX1 ADCK2 AGGF1 AK1 AKT3 ALDH4A1 ANXA11 ANXA2 ARAF ARIH2 ATF3 AURKC BAX BFAR BMX BRD3 BRSK2 C13orf15 C19orf21 C1orf177 C20orf19 C9orf9 CAMKK1 CARHSP1 CAT CBFA2T2 CCM2 CCNB1 CD37 CD59 CDCA5 CDK2 CDK5 CDK6 CENPT CENTG1 CFL2 CHGB CHIP CIAO1 CKM CKMT1B CLK3 CNOT10 CNOT8 COX17 CPEB2 CRAT CREB3L1 CRIP1 CRY1 CSNK1A1 CSNK1E CSNK1G2 CSRP1 CSRP3 CSTF2T CUGBP1=CELF1 DDEFL1 DDX39 DDX50 DEPDC7 DIABLO DOK1 DYNC1I1 EEF2K EFCBP1 EIF4H MAPK1 ETFB EXOSC3 EXOSC5 EYA2 FABP3 FHL1 FHL2 FOXI1 GAPDH GATA1 GLTPD1 GOT1 GSN HAT1 HK1 HK2 HLCS HNRNPK HSF4 HSPA1L HSPA2 HSPB1 ID2 IMP4 IRF3 IVNS1ABP JMJD2D MAPK8 KHDRBS2 KHDRBS3 KIAA0892 KLHDC4 KLHL1 KLHL13 KRR1 LAGE3 LIG1 LSM3 LYPD5 LYPLAL1 LZTS2 MAGEA4 MAP2K2 MAP2K4 MAPK10 MAPK12 MAPK13 MAPKAPK3 ME1 MEF2B MLLT6 MLX MNAT1 MPP1 MRPL53 MRPL55 MRPS36 MTCP1 NA NCBP2 NFATC3 NFU1 NOL10 NOL7 NOLC1 NUP35 NUP62 NUSAP1 ODC1 ORC4L OXSR1 P4HB PAIP1 PCK2 PCNP PDGFRA PDK2 PDK4 PDS5A PECI PFKM PGAM2 PIK3C3 PIM2 PITX1 PKNOX1 PLAGL2 PLCD4 PLK3 POGK POLD4 POLR2I POLS PPARBP PPARD PPIH PPP2CA PPP2R1B PPP2R4 PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E PRDM10 PRDX1 PRDX2 PRKACB PRKCA PRKCDBP PRKCH PTRH2 PUM2 RAB14 RAB5B RAB5C RAD23B RAP1A RBM12 RBM27 RCVRN RIPK3 RNF13 RNF181 RNUXA RPA1 RPS6KA2 RUNX1T1 RXRA S100A11 SGK2 SGK494 SIAHBP1 SIRT5 SIVA1 SMAD7 SMYD5 SNCA SNRPA SPEG SRA1 SSBP3 SSBP4 STAG3 STIP1 STK25 STK24 SUMO1 TAGLN2 TEAD1 TERF2IP TFEB TFIIB TGFBR2 THOC1 THRAP6 TIP60 TIPIN TK1 TOMM34 TPI1 TREX1 TRIM69 TSN TST UBE2N UBE2V1 UBTD2 ULK2 UNG UQCRB UROS USF1 UTP6 VAMP4 VPS39 XPA XPO1 YWHAE YWHAZ ZCCHC8 ZDHHC11 ZDHHC5 ZFP516 ZKSCAN3 ZMYM3 ZNF219 ZNF239 ZNF250 ZNF281 ZNF289 ZNF324 ZNF35 ZNF397 ZNF410 ZNF428 ZNF576 ZNF588 ZNF614 ZNF655 ZNF706 ZSCAN2 ZW10 ZYX

Proteomic profiling of EBNA1-host protein interactions in latent and lytic Epstein-Barr virus infections.Malik-Soni and Frappier, 2012

Proteins copurifying with EBNA1: AZI2 C1QBP CSNK2A1 CSNK2A2 CSNK2B GMPS NPM1 PRMT5 SET USP7

Comparing proteomics and RISC immunoprecipitations to identify targets of Epstein-Barr viral miRNAs.Kuzembayeva et al, 2012

candidates identified as being regulated by the miRNAs via 2D DIGE ACTB ANXA7 BPGM CALR CFL1 CNBP DUT EIF5A ENO1 EZR FABP5 GSN GSTP1 HSP90AB1 HSPA5 HSPA9 HSPD1 ISG15 MZB1 NAP1L1 NUDT5 PDIA3 PGAM1 PPA1 PRDX1 RPLP2 SET SRSF1 SYNCRIP TCP1

Proteomics analysis of gastric epithelial AGS cells infected with Epstein-Barr virus Ding et al, 2013

Increased expression: ACTB CASP9 HSPA8 PNPO TCP1 Decreased expression: CAPG CDK2 GDF11 ZFP2

Differential Gene Expression Patterns of EBV Infected EBNA-3A Positive and Negative Human B Lymphocytes Hertle et al, 2009

EBNA-3A cellular target genes

Downregulated ADAM19 ADAM28 ADAMDEC1 AKT3 ANKMY2 APLP2 ARHGAP25 ASAHL ATP2B4 ATXN1 BANK1 BMP4 BZW2 C10orf38 C3orf52 C6orf105 C6orf149 CDH1 CDK5R1 CDKN2A CEBPB CHST2 CITED2 CKLF CMTM6 CPA4 CPEB1 CREB5 CRY1 CXCL10 CXCL9 CXCR4 E2F5 EBI2 EHD1 ELK3 ENTH EPB41L4B EVI2B FAM38B FAM3C FAM49A FARS2 FHL1 FHOD3 FLJ20054 FOXO1A FOXO3A FRAT1 GIMAP4 GIMAP5 GIMAP6 GLS GPR15 GPX7 HDAC9 HECA HEY2 ID1 IFT57 IGJ IL18R1 IL1R2 JAK1 JARID1B KIAA0672 KIAA0746 KIAA0984 KIAA1659 KLF12 LEPREL1 LOC220594 MAP4K4 MARK1 METTL7A MOSC2 MTUS1 MYO1F NCALD NDFIP1 NMT2 NOTCH2 NRCAM NUAK2 OAT OSBPL10 PDE4D PDLIM3 PERP PHF16 PLEKHC1 PRKACB PRKCA PTGER4 PTPN13 PTPN3 RAI14 RAP2A RCN2 RGPD5 RGS2 RPS6KA5 RYBP S100A10 SAMSN1 SCARB2 SDC1 SLC12A6 SLC1A4 SLC23A2 SNCAIP SOX4 ST3GAL6 STAT4 STK17B STK39 SV2B TESC THRAP2 TMEM22 TREM1 TRIB1 TRIO TXNDC5 TXNIP UGT8 UST ZCCHC11 ZFAND6

Upregulated ABCC4 ACSM3 ACTN1 AIF1 AIM2 ALOX5 ATP7A B4GALT6 BIN1 BIRC3 BIRC4BP C14orf105 CAPG CASK CCL3 CCL4 CCL5 CCND2 CD24 CD244 CD52 CEBPD CHL1 CHST12 CHST7 CKAP4 COL5A1 CRIM1 CRYZ CSRP2 CST3 CTNND1 CTSS CYBB CYP7B1 DBNDD2 DDR1 DDX58 DMD DNAPTP6 DTNB DUSP10 DUSP5 EGLN3 EIF2AK2 ENDOD1 ENPP2 ETV5 EXTL2 FAM13A1 FLJ20035 FLJ36166 FLNB FTH1 FXYD2 GABBR1 GAS2 GAS7 GNPTAB GPC4 GSTM3 HERC5 HERC6 HOXB2 HPCAL1 ID2 IFI27 IFI44 IFI6 IFIH1 IFIT1 IFIT5 IFNA2 IGHM IL17RB IPCEF1 ITGAM KCNK1 KCNN3 KIAA1217 KRAS LGALS8 LIPG LMO3 LOC54103 LST1 LTA LTB MAPKAP1 MARCH3 MCTP1 MCTP2 ME1 MLSTD1 MMP7 MNDA MT2A MX2 MYO1E MYO6 NEFH NFIB NID1 NMI NOL3 NTRK2 OAS1 OAS3 OASL OSR2 OXTR P2RY5 PARD3 PARP12 PBX3 PDCD1LG2 PDLIM2 PDLIM4 PEG10 PHLDA1 PIAS2 PILRA PIR PLA1A PLAC8 PLSCR1 PPFIA4 PTAFR PTGS1 RAB13 RAP2B RAPGEF5 RB1 RCBTB2 RGC32 RIN3 S100A4 S100A6 SCHIP1 SELL SEMA6A SLC1A1 SLC7A11 SMAD3 SNX10 SPRY1 SPTLC2 ST3GAL5 STAG3 STAT1 STEAP1 SYNE2 TBX21 TMEM23 TMEM45A TNF TNFAIP2 TNFAIP8 TNFRSF21 TNFSF10 TNFSF11 TNFSF13 TNFSF14 UGCG UPP1 YES1 ZNF318 ZNF83

Epstein–Barr virus transcription factor Zta acts through distal regulatory elements to directly control cellular gene expression Ramasubramanyan et al, 2015

Misregulated genes during the viral lytic replication cycle

Upregulated: A2M A4GALT ABCA12 ABCA13 ABCA2 ABCA9 ABCC2 ABCC4 ACCN2 ACO1 ACTA1 ACTG2 ACTL8 ACTN1 ACTN2 ACVR1C ACVR2A ADAM11 ADAMTS14 ADAMTS17 ADAMTS18 ADAMTS3 ADAMTS6 ADAMTS9 ADAMTSL1 ADAMTSL3 ADAT3 ADCY1 ADCY9 ADIPOQ ADNP2 ADPRHL1 AFAP1 AGAP1 AGAP11 AGPAT9 AGTR1 AHNAK AHR AKAP10 AKR7L AKT3 ALB ALDH1A2 ALDH1A3 ALDH8A1 ALK ALPP ALPPL2 AMACR AMBN AMIGO1 AMPD3 ANK3 ANKRD12 ANKRD20A4 ANKRD20A9P ANKRD22 ANKRD26P1 ANKRD30A ANKRD30B ANKRD30BP2 ANKRD34C ANKRD5 ANKRD6 ANKS1B ANO1 ANO3 ANO5 ANTXR2 ANXA1 ANXA2 AOX1 APAF1 APBA2 APC APC2 APOB APOL4 APP ARHGAP20 ARHGAP21 ARHGAP23 ARHGAP26 ARHGAP28 ARHGAP29 ARHGAP31 ARHGAP5 ARHGEF10 ARHGEF12 ARHGEF3 ARID3B ARID4A ARID5B ARL13B ARL5B ARNT2 ARRB1 ARRDC4 ASB5 ASH1L ASXL3 ASZ1 ATAD3C ATAD5 ATCAY ATF3 ATF7IP2 ATG9B ATL2 ATP10B ATP11A ATP13A3 ATP6V0A4 ATP7A ATP8B1 ATP8B4 ATP9A ATXN1 B3GNT2 B3GNT4 B3GNT5 B3GNT9 BAG3 BAG4 BAI3 BAIAP2 BAIAP2L1 BAZ2B BBS5 BBX BCAR1 BCAR3 BCAS1 BCL2A1 BDKRB1 BDNF-AS1 BEGAIN BEST2 BFSP1 BIN1 BIVM BMPR1B BMPR2 BNC2 BNIP3 BNIPL BPIFC BRCA2 BRIP1 BROX BSND BTBD11 BTBD7 BTNL8 BVES C10orf118 C10orf12 C10orf137 C10orf58 C11orf74 C12orf53 C12orf69 C14orf118 C14orf55 C15orf55 C16orf73 C17orf104 C17orf85 C18orf1 C18orf25 C18orf54 C19orf29-AS1 C19orf40 C1orf106 C1orf126 C1orf127 C1orf130 C1orf186 C1orf198 C1orf200 C1orf226 C1orf229 C1orf51 C1orf63 C1QTNF3-AMACR C1QTNF6 C2 C20orf112 C20orf152 C20orf194 C20orf26 C20orf94 C21orf7 C2CD2 C2orf91 C3orf38 C3orf58 C3orf64 C4orf26 C4orf49 C5orf27 C5orf41 C6 C6orf99 C7orf53 C7orf58 C7orf60 C8orf84 C9orf25 C9orf30-TMEFF1 C9orf43 CA12 CACNA1C CACNA1D CACNA1G CACNA1H CACNA1S CACNA2D4 CACNB2 CALCRL CAMK2B CAMSAP2 CAND2 CAPN2 CAPN3 CARD6 CASC5 CASKIN1 CASP14 CASP3 CASP8 CASS4 CASZ1 CATSPERG CCDC103 CCDC135 CCDC136 CCDC141 CCDC150 CCDC155 CCDC168 CCDC9 CCNT1 CCNYL1 CCRN4L CD109 CD14 CD164L2 CD200R1 CD200R1L CD209 CD2AP CD59 CD68 CD9 CDC42BPB CDCA2 CDH1 CDH23 CDHR3 CDK12 CDK5R1 CDKN2AIP CDKN2B CDON CDS1 CENPL CEP128 CEP97 CERS6 CETP CFH CFTR CHAF1B CHL1 CHM CHRNA3 CHRNB2 CHST3 CILP CLCA2 CLCN4 CLEC2B CLEC4A CLIC5 CLIP1 CLOCK CMBL CMYA5 CNR2 CNTF CNTN5 CNTNAP1 CNTNAP2 CNTNAP3 CNTNAP3B COL11A1 COL12A1 COL1A2 COL2A1 COL3A1 COL4A1 COL5A1 COL5A2 COL6A5 COL6A6 COL9A1 COLEC11 CORIN CORO2A CPA4 CPD CPEB2 CPEB3 CPEB4 CPLX3 CPM CPNE6 CR2 CRABP2 CRB2 CRCP CRIM1 CRKL CRMP1 CROT CRTC3 CRY2 CRYGS CRYM CSMD1 CSMD3 CSNK1G1 CSRNP2 CTAGE10P CTAGE4 CTAGE6P CTBP2 CTDSPL2 CTNNA1 CTSK CTSW CUBN CUZD1 CX3CR1 CXADRP2 CYFIP1 CYP19A1 CYP1B1 CYP2C9 CYP3A4 CYP3A5 DAAM1 DAB2IP DAPK1 DCC DCDC5 DCHS1 DCHS2 DCLRE1A DCLRE1B DCP1A DCT DCUN1D3 DDHD2 DDI2 DDX12P DDX60 DDX60L DENND1B DENND4C DENND5A DGKB DHCR24 DIAPH3 DIP2B DIP2C DISC1 DKK4 DLC1 DLG3 DLGAP2 DLL1 DLX2 DMBT1 DMD DMRT1 DMXL2 DNA2 DNAH10 DNAH12 DNAH14 DNAH17 DNAH3 DNAH5 DNAH6 DNAH7 DNAH8 DNER DOCK1 DOCK10 DOCK3 DOCK4 DOCK5 DOCK7 DPF1 DPF3 DPP8 DPY19L2 DPY19L2P2 DPYSL3 DRP2 DSE DSG1 DSG2 DSG3 DSG4 DSP DST DSTNP2 DTNA DUSP16 DUSP19 DUSP5 DUSP6 DUSP8 DYNC2H1 DZIP1 E2F7 EBF2 EBF3 EBF4 EDAR EDN1 EDNRB EEF1E1-MUTED EFCAB5 EFNB2 EFR3B EGF EGR1 EGR2 EIF2C2 EIF2C3 ELMOD1 EML1 EML5 EMP1 EMR1 EMR2 ENC1 ENPP1 ENPP2 ENPP5 ENPP6 EP300 EPB41L1 EPB41L2 EPB41L5 EPHA4 EPHA7 EPHB3 EPHX1 EPM2AIP1 EPS8 ERBB3 ERBB4 ERC1 ERC2 ERCC6L EREG ERVFRD-1 ESCO2 ESR2 ESRG ESRRG ETS2 ETV5 EVI5 EXOC6B F13B F5 F8 FAM105A FAM114A1 FAM115A FAM115C FAM135B FAM13A FAM13B FAM154B FAM169A FAM169B FAM171A1 FAM172A FAM174B FAM179A FAM184B FAM189A1 FAM190B FAM27A FAM46B FAM46C FAM53A FAM63B FAM65C FAM83C FAM90A13 FAM90A14 FAM90A7P FAM91A1 FAN1 FANCB FARP1 FAT2 FAT4 FBLN1 FBN1 FBN2 FBXL17 FBXO28 FBXO32 FBXW4P1 FCER1G FCGR2A FCHO2 FEM1C FER FER1L6 FERMT1 FERMT2 FGD4 FGD6 FGF14 FGF18 FGF5 FGFR1 FHDC1 FHL2 FILIP1 FLJ25758 FLJ34690 FLJ36000 FLRT3 FLT1 FMN1 FN1 FNBP1L FNDC1 FOS FOSB FOSL2 FOXD4L1 FOXD4L3 FOXD4L6 FOXL1 FOXP2 FRAS1 FREM2 FRK FRMD4A FRMD4B FRMD6 FRMPD1 FRS2 FRY FSCN1 FSIP1 FUT9 FYB FZD1 FZD10 GAB2 GABBR2 GABRA1 GABRB2 GABRG1 GADD45B GALNT6 GAN GATA3 GATM GATSL2 GBP1 GBP2 GBP4 GBP5 GCM1 GDAP1L1 GDF2 GDF5 GDF9 GFAP GFPT2 GGT7 GHRL GJA1 GLDC GNN GNRH1 GOLGA6C GOLGA7B GOLGA8DP GOLGA8E GPAM GPATCH2 GPATCH8 GPC4 GPC6 GPR125 GPR126 GPR158 GPR176 GPR183 GPR19 GPR3 GPR56 GPR68 GPR75 GPR83 GPR87 GPRC5C GRB10 GREB1 GRHL1 GRIN2A GRIN2D GRM4 GRM5 GSG1 GTF2IRD2 GTF3C4 GUCY1A3 H1F0 HAL HAPLN3 HAS2 HAUS6 HAVCR2 HCFC2 HECTD2 HECW2 HEG1 HELZ HERC2P3 HES6 HHLA2 HIST1H2BJ HIST1H2BO HIST1H3D HIST1H4K HIST2H2AA3 HIST2H2AA4 HIST2H2BE HIST2H2BF HIVEP1 HMCN1 HNRPLL HOMER1 HOXB7 HPSE HS3ST2 HS6ST3 HSD17B13 HSP90AB2P HSPA12A HSPA1A HSPA1B HSPA6 HSPB1 HSPC072 HUNK HYDIN IAPP ICA1L IDI2-AS1 IER3 IER5L IFFO2 IGF1R IGSF1 IGSF10 IGSF3 IKZF5 IL11 IL15RA IL17RC IL18R1 IL18RAP IL1R1 IL1RAP IL5RA IL6R IMPG2 INMT INPP5F INSL5 INTS6 IPCEF1 IPW IQCG IQGAP2 IRAK2 IRF4 IRF6 IRX4 ISLR2 ITCH ITGA2 ITGA6 ITGAM ITGAV ITGB8 ITIH3 ITK ITM2C JAG1 JAK2 JAM3 JHDM1D JMJD1C KAL1 KALRN KANK1 KAZN KCNH1 KCNH3 KCNJ10 KCNK1 KCNK10 KCNK2 KCNMA1 KCNQ4 KCNS1 KCNV2 KCP KDELC1 KDM4D KDM5A KDM5B KDR KGFLP1 KIAA0232 KIAA0319 KIAA0368 KIAA0513 KIAA0825 KIAA0889 KIAA0895 KIAA0907 KIAA0947 KIAA1107 KIAA1199 KIAA1239 KIAA1244 KIAA1328 KIAA1522 KIAA1549 KIAA1671 KIAA1804 KIAA2018 KIDINS220 KIF16B KIF18A KIF1B KIF26B KIF5A KIF5C KIF9 KIFC3 KIRREL3 KLB KLF5 KLF9 KLHL11 KLHL15 KLHL20 KLHL28 KLHL3 KLHL31 KLHL7 KLHL7-AS1 KLK2 KLLN KMO KRBA2 KRT18 KRT8 LAMA1 LAMA2 LAMA3 LAMB1 LAMB2 LAMC1 LAMP5 LAPTM4B LATS1 LCA5 LCTL LDHAL6B LEPR LGR4 LHFPL2 LHX1 LIFR LILRA6 LIMD1 LIN52 LIN9 LINC00115 LINC00174 LINC00346 LIPH LMLN LMOD3 LNPEP LNX1 LOC100128164 LOC100128288 LOC100129269 LOC100129617 LOC100129931 LOC100130950 LOC100133612 LOC100188947 LOC100216545 LOC100271836 LOC100272216 LOC100288181 LOC100289211 LOC100289361 LOC100505576 LOC100507043 LOC100507062 LOC100507401 LOC158696 LOC219347 LOC255512 LOC256880 LOC283624 LOC283663 LOC284412 LOC285696 LOC338817 LOC339166 LOC349196 LOC375010 LOC392196 LOC641298 LOC642846 LOC643201 LOC643406 LOC643955 LOC644669 LOC644714 LOC644961 LOC646214 LOC648987 LOC652276 LOC653061 LOC653075 LOC678655 LOC728323 LOC728407 LOC728537 LOC729444 LOC729513 LOC730101 LOC91948 LONRF2 LOX LPAR1 LPCAT2 LPGAT1 LPHN2 LPHN3 LPIN2 LPIN3 LPL LPP LPPR4 LRP2 LRP4 LRP5L LRP6 LRRC31 LRRC49 LRRC70 LRRC8B LRRC8C LRRC8E LRRK2 LSAMP LTBP2 LTBP3 LTN1 LUZP1 LYST LZTFL1 MACF1 MACROD2 MAGI1 MALL MAML1 MAP1B MAP3K2 MAP3K8 MAP6 MAP7 MAP7D2 MAP9 MB MBD5 MBOAT1 MCART6 MCC MCF2L2 MCM10 MECOM MED12L MED13 MED13L MEFV MEGF9 MERTK MESTIT1 MET METTL16 METTL21C MEX3D MFAP3L MFSD4 MGAM MGAT4A MGC16142 MGC16275 MIB1 MICAL2 MICALCL MICALL1 MID1 MITF MLC1 MLK7-AS1 MLKL MMP25 MMP9 MOB3B MOBP MPDZ MPP7 MRAS MRC1 MRGPRX3 MRVI1 MS4A14 MTBP MTMR10 MTRNR2L1 MTRNR2L10 MTRNR2L2 MTRNR2L3 MTRNR2L4 MTRNR2L5 MTRNR2L6 MTRNR2L8 MTSS1 MUC20 MUC4 MURC MX2 MXD1 MYADM MYBPC2 MYBPH MYH10 MYH11 MYH15 MYH3 MYH8 MYLK2 MYO10 MYO1B MYO3B MYO5B MYO5C MYO6 MYOM1 MYOZ3 MYT1 N4BP2L1 NAAA NAALAD2 NALCN NANOG NAV2 NAV3 NBEAL1 NBPF1 NBPF10 NBPF11 NBPF14 NBPF22P NCEH1 NCF2 NCKAP5L NDST3 NEB NEBL NEDD4 NEDD9 NEFH NEFL NEFM NEK11 NFASC NFATC2 NFIA NFIC NFIX NFKBIZ NHLH1 NHLRC2 NHSL1 NID1 NINL NKIRAS1 NLRC4 NLRP2 NLRP7 NOS1 NOTCH2 NOTCH3 NPAS3 NPAS4 NPHP1 NPR3 NR3C2 NR4A3 NR5A2 NRCAM NRIP1 NRP2 NRXN1 NSUN4 NT5E NTRK2 NUSAP1 NWD1 OCLN ODZ2 ODZ3 ODZ4 OLFML2B OPRK1 OR2B6 OR2C1 OR51I1 OR5AU1 ORC1 ORM1 OSBPL1A OSMR OSR2 OTOGL OTUD6B OTUD7B OVGP1 PADI2 PADI3 PAK6 PALM2 PAPPA PAPSS2 PAQR5 PAQR7 PARD3 PARD3B PARP14 PAX3 PAX6 PCDH1 PCDH15 PCDH17 PCDH19 PCDH8 PCSK5 PCSK6 PDE10A PDE11A PDE1B PDE1C PDE3A PDE4D PDE4DIP PDE5A PDGFRB PDYN PDZD2 PDZK1 PDZK1P1 PDZRN3 PEG10 PEG3 PELI2 PEX5L PFN2 PGAP1 PGM2L1 PGM5P2 PHACTR2 PHLDB2 PHOSPHO1 PI15 PIEZO2 PIK3R3 PION PITX1 PIWIL2 PIWIL3 PKD2 PKHD1 PKIB PKNOX1 PLA2G4C PLA2G4D PLA2G4E PLAC2 PLAT PLAUR PLCB4 PLCD4 PLCE1 PLCH1 PLCL1 PLD1 PLD6 PLEKHA5 PLEKHH2 PLEKHM3 PLIN2 PLK2 PLS1 PLXDC1 PLXNA4 POLG2 POLR2A POTEE POTEF POTEM POU6F1 PPAP2B PPAPDC1B PPARA PPARG PPM1E PPM1H PPP1R12A PPP1R1B PPP1R9A PPP4R1L PRDM1 PRDM7 PRICKLE2 PRKAB2 PRKACB PRKAR2A PRKCH PRKD1 PRKG1 PROS1 PROX1 PRPH PRR15L PRRG4 PRRT2 PRTG PRUNE2 PSD3 PSTPIP1 PSTPIP2 PTCH1 PTCHD4 PTGER3 PTGFR PTGIS PTGS2 PTPN12 PTPN13 PTPN14 PTPN21 PTPN3 PTPRB PTPRD PTPRF PTPRH PTPRK PTPRT PTPRZ1 PTRF QKI RAB11FIP1 RAB15 RAB3B RABGEF1 RAD54B RAI14 RAP1GAP RAPGEF4 RASA3 RASAL2 RASD2 RASGRF2 RASL11A RASSF8 RB1CC1 RBAK RBL1 RBM12 RBM15 RBM20 RBM27 RBM43 RBM48 RBMS1 RBMS3 RC3H2 RDH16 RDX RECK REV3L REXO1L1 RFPL1-AS1 RFPL3-AS1 RFPL4A RFTN2 RGL1 RGNEF RGPD1 RGPD4 RGPD5 RGS12 RGS2 RGS4 RGS5 RGS9 RHBG RHOBTB3 RHPN2 RIC8B RICTOR RIMBP2 RIMS1 RIMS4 RIN2 RLF RMRP RNF103-CHMP3 RNF11 RNF144A RNF157 RNF169 RNF2 RNF219 RNF43 RNPC3 ROBO2 ROR2 RORA ROS1 RPPH1 RRAGC RSAD2 RSBN1 RSPH3 RUNDC3B RXFP1 RYR2 RYR3 S1PR3 SALL4 SASH1 SBSN SCAI SCAPER SCARA5 SCARB2 SCARNA2 SCEL SCG5 SCIMP SCN1A SCN2A SCN3A SCN3B SCN7A SCN8A SCN9A SDC4 SDSL SECISBP2 SECTM1 SEMA3B SEMA3D SEMA4D SEMA5A SEMA5B SEMA6D SEMA7A SEMG1 SERHL2 SERPINA9 SERPINB6 SERPINB8 SERPINF1 SERTAD1 SETBP1 SFN SFRP1 SGIP1 SGK1 SGK3 SGMS2 SGOL2 SH3BGRL2 SH3D19 SH3KBP1 SH3PXD2A SH3YL1 SHISA2 SHROOM2 SHROOM3 SHROOM4 SI SIGLEC1 SIK2 SIRPA SKIL SLAMF7 SLC12A7 SLC12A8 SLC15A1 SLC16A4 SLC18A2 SLC1A2 SLC1A3 SLC22A1 SLC26A4 SLC26A7 SLC26A9 SLC27A2 SLC28A3 SLC31A2 SLC34A2 SLC35D2 SLC35F1 SLC37A2 SLC39A12 SLC41A2 SLC45A3 SLC47A1 SLC4A10 SLC4A4 SLC4A7 SLC5A1 SLC5A5 SLC6A14 SLC6A4 SLC6A7 SLC7A14 SLC7A2 SLC9A1 SLC9A2 SLIT1 SLITRK3 SLITRK6 SLK SMA5 SMAD7 SMO SMURF1 SMURF2 SMYD4 SNAI1 SNORA67 SNTB2 SNX16 SNX29 SNX9 SORBS1 SORBS2 SORL1 SORT1 SOX5 SOX6 SP4 SPAG1 SPAG5-AS1 SPARCL1 SPATS2L SPDYE8P SPINK5 SPIRE1 SPNS2 SPOCD1 SPOCK1 SPON1 SPOPL SPP1 SPRED1 SPTA1 SPTY2D1 SRC SRCRB4D SRGAP1 ST8SIA1 STAT5A STC1 STEAP2 STEAP3 STK31 STMN2 STON1 STON2 STRN STXBP4 STXBP5 STXBP5L SULF1 SV2B SVEP1 SVIL SWT1 SYNJ1 SYNJ2BP SYNM SYNPO2 SYT1 SYT11 SYT12 SYTL2 SYTL3 TAF3 TAF5 TANC2 TAOK1 TAS1R1 TBC1D10A TBC1D9 TBCCD1 TBX18 TCHH TDRD7 TET1 TET2 TEX14 TEX29 TFCP2L1 TFEC TGFB2 TGFBR2 TGFBR3 TGIF2-C20ORF24 TGM2 THAP1 THAP2 THBD THBS1 THBS2 THNSL2 THRA THRB THSD1 THSD4 THSD7A TIAM1 TIAM2 TIGD3 TIMP3 TIPARP TJP1 TLL1 TLR2 TMC5 TMCC3 TMEM136 TMEM212 TMEM236 TMEM55A TMEM56 TMX2-CTNND1 TNFAIP3 TNFRSF10D TNFRSF1B TNFSF15 TNKS TNN TNNT1 TNPO1 TNRC6B TNRC6C TNXB TOB2 TPPP TRAF3IP1 TRAK2 TRIM2 TRIM24 TRIM53P TRIM55 TRIM68 TRIM69 TROVE2 TRPC1 TRPM6 TRPM8 TSG1 TSHZ2 TSPAN13 TTC39B TTC39C TTF2 TUFT1 TUSC5 TYW1B UBN2 UCP3 UGT2A3 UHMK1 ULK2 UNC13C UNC5C UNC79 UNC80 USH2A USP17 USP17L2 USP17L6P USP29 USP31 USP37 USP38 USP49 USP6 USP8 UST UTS2D VANGL1 VANGL2 VAV3 VCAN VCPIP1 VEZF1 VPS13B VRK2 VWA5A VWA7 VWF WASL WDFY3 WDR52 WDR76 WDR78 WDR96 WDSUB1 WFIKKN1 WFIKKN2 WHAMMP2 WHAMMP3 WNK3 WNT2 WT1 WWC2 WWC3 WWTR1 XIRP2 XKR3 XKR8 XRN1 YAP1 YPEL2 YPEL4 ZAK ZBTB11 ZBTB37 ZBTB38 ZBTB41 ZBTB43 ZBTB8B ZC3H12C ZCCHC14 ZDBF2 ZEB1 ZEB2 ZFP2 ZFP82 ZFYVE20 ZFYVE9 ZIC3 ZKSCAN5 ZNF12 ZNF136 ZNF14 ZNF143 ZNF148 ZNF155 ZNF160 ZNF165 ZNF20 ZNF233 ZNF234 ZNF267 ZNF28 ZNF280B ZNF286B ZNF292 ZNF317 ZNF323 ZNF333 ZNF34 ZNF35 ZNF383 ZNF430 ZNF432 ZNF433 ZNF438 ZNF440 ZNF441 ZNF460 ZNF468 ZNF471 ZNF473 ZNF486 ZNF510 ZNF521 ZNF525 ZNF541 ZNF551 ZNF556 ZNF567 ZNF57 ZNF570 ZNF571 ZNF606 ZNF610 ZNF614 ZNF615 ZNF616 ZNF618 ZNF626 ZNF627 ZNF654 ZNF669 ZNF670 ZNF699 ZNF701 ZNF702P ZNF704 ZNF705A ZNF705D ZNF714 ZNF77 ZNF791 ZNF8 ZNF80 ZNF813 ZNF831 ZNF844 ZNF845 ZNF850 ZNF876P ZNF92 ZNF93 ZNRD1-AS1 ZPLD1 ZRANB1 ZSCAN12P1 ZYG11A

Downregulated: ABCA7 ABP1 ACAP3 ACAT2 ACE ADAM1 ADAMTS13 ADCY5 ADI1 AGER AGMO AGPAT4 AGPAT4-IT1 AGXT2L2 AHNAK2 AHRR AICDA AIFM2 AIM2 AK1 AKR1C3 ALDH1A1 ALDH1L1 ALKBH2 AMT ANKRD13B ANKRD13D ANKRD36BP2 ANKRD65 ANXA6 ANXA9 AOC3 AP3B2 APOBEC3H APOLD1 ARHGAP27 ARHGAP30 ARHGAP9 ARHGEF18 ARL1 ARMCX3 ARVCF ASAP3 ATHL1 ATP6V0B ATP6V1C2 ATP6V1G2 ATP8A2 AZGP1P1 B4GALT3 BAIAP3 BAX BCAS4 BCAT2 BCL2L1 BCL3 BCRP2 BEST3 BFSP2 BIK BLCAP BMP3 BTG2 BTN3A1 BTN3A2 BTN3A3 C10orf10 C11orf9 C11orf92 C14orf1 C14orf149 C14orf159 C15orf37 C16orf48 C16orf86 C17orf65 C17orf72 C19orf10 C19orf38 C2orf63 C2orf74 C3orf32 C4B C6orf223 C7orf23 C7orf50 C8orf44-SGK3 C8orf73 C8ORFK29 C9orf129 C9orf174 C9orf9 C9orf95 CA11 CACNB1 CACNB3 CALR CAMK2N1 CAMP CAPN10 CARD16 CASP1 CBLN1 CBX7 CCDC24 CCDC74A CCDC78 CCM2 CCRL2 CCS CD22 CD27 CD37 CD38 CD3E CD40 CD48 CD52 CD72 CD79A CD79B CD86 CDC25B CDH15 CDK18 CDK2AP2 CDKN1A CDNF CECR1 CEND1 CHRNA2 CKB CLDN15 CNPY2 CNPY3 CNR1 COL18A1 COL9A3 COMT COQ10A CPNE2 CPNE5 CPT1B CRELD1 CRELD2 CRHBP CROCC CRYBB1 CSTA CYB561D2 CYBA CYP1A1 CYP2E1 CYP39A1 CYP4F12 CYP4F2 CYSLTR1 DAPL1 DBI DBN1 DGKA DHRS12 DKKL1 DNAH1 DNAJB11 DNAJC28 DNHD1 DNLZ DNM1 DPYSL4 DUSP26 EBI3 EGFL7 EGFL8 EGFR EHBP1L1 EMP3 ENO3 EPHB4 EPM2A EVI2B EXD3 EXOC3L4 FABP6 FADS2 FAIM3 FAM113A FAM129C FAM160B2 FAM210B FAM213B FAM43A FAM65A FAM86C1 FAM86C2P FAM86HP FAM89B FAM9B FBLN5 FBRSL1 FBXL19 FBXW12 FCGR2B FCRL1 FCRLA FGD2 FGFRL1 FKBP11 FKBP2 FLI1 FLJ10038 FLJ10661 FLJ39653 FLJ41484 FLT3LG FSTL3 GABARAPL1 GABBR1 GBAP1 GBGT1 GCET2 GDF11 GDPD3 GGT5 GH1 GIMAP2 GIMAP4 GJB4 GLB1L2 GLI1 GLRX GLT8D1 GLTPD1 GMPPA GMPPB GNG7 GPC1 GPR162 GPR173 GPR35 GPSM1 GPSM3 GRAP GRIN2C GRINA GSDMB HCG4 HDAC7 HES7 HLA-DMB HLA-DOA HM13 HMGCS1 HOOK2 HPSE2 HSD17B14 HSD17B6 HSD17B7P2 HSF4 HVCN1 ICAM2 ID3 IFI27L2 IFI6 IGDCC3 IGFBP2 IGFLR1 IGLL1 IKBKE IL12RB1 IL16 IL21R IL23A IL32 IL7R INHBC INHBE INO80B-WBP1 ISG20 ISYNA1 ITGAD ITGB2 ITGB7 JAG2 JAGN1 JSRP1 KATNAL2 KCNN4 KCTD17 KIAA0284 KLF13 KLRK1 KRBA1 KRI1 LAPTM5 LDHD LDLRAP1 LEFTY2 LHFP LIME1 LINC00263 LINC00494 LIPI LITAF LOC100128881 LOC100129196 LOC100131067 LOC100131096 LOC100131733 LOC100287177 LOC100293534 LOC100422737 LOC100499227 LOC100505622 LOC100505746 LOC100506649 LOC100507003 LOC100507217 LOC100507501 LOC146880 LOC148413 LOC282997 LOC283693 LOC283710 LOC283888 LOC375190 LOC400236 LOC400604 LOC401431 LOC619207 LOC653566 LOC728392 LOC728743 LOC729683 LOC79015 LPAR2 LPAR5 LPPR2 LRCH4 LRG1 LRRC14B LRRC24 LRRC56 LSS LST1 LTB LTBP4 LY6E LY86 MAMDC4 MANF MAP3K11 MAP3K12 MCEE MEIS1 METAP1D MEX3A MFAP4 MFI2-AS1 MFSD3 MGC39372 MIR17HG MOCOS MST1 MST1P2 MSTO1 MTERFD3 MTSS1L MUC16 MVD MYC MYL5 MYLK MYO9B MZB1 NARFL NAT14 NBEAL2 NCF4 NDRG4 NEAT1 NECAB3 NFAM1 NFATC4 NGFR NINJ1 NLRP1 NME3 NOX4 NOXA1 NPAS1 NPHP3-ACAD11 NRL NUDT16 NUDT9P1 NUMA1 NYNRIN OR13A1 ORAI2 ORMDL3 OSBP2 OSTC P2RY8 PACSIN1 PBXIP1 PCBP4 PCGF2 PCSK4 PCSK9 PCYOX1L PCYT2 PDCD4 PDIA6 PDLIM3 PEAR1 PEMT PFDN2 PI16 PILRA PILRB PKD1 PLA2G2D PLA2G4B PLD4 PLEKHG4B PLEKHH3 PLXND1 PORCN PPCDC PPIB PPM1K PPM1M PPM1N PRAF2 PRICKLE4 PRKCG PSEN2 PSMA8 PTPN22 PUS1 PVRIG PXDNL PYHIN1 RAG1 RAG2 RASGEF1A RASGRF1 RASGRP2 RASIP1 RASL10B RBM14-RBM4 RBM24 RCSD1 REXO2 RFX1 RHBDF2 RHPN1 RNASEK-C17ORF49 RNF144B RRBP1 RTN4R RWDD2B S100A13 S100A4 S1PR4 SDF2L1 SDR39U1 SEC11C SEC61A1 SEC61B SELS SEMA4A SEMA6C SERF1A SH2D3A SH2D3C SIT1 SLAMF6 SLC22A5 SLC23A1 SLC25A27 SLC27A3 SLC29A2 SLC2A4 SLC2A6 SLC30A2 SLC38A10 SLC39A11 SLC39A7 SLC43A2 SLC44A2 SLC50A1 SLC6A16 SMTN SNED1 SNX15 SOCS1 SOHLH2 SOWAHD SPATA20 SPI1 SPINK2 SPINT1 SPIRE2 SPN SPPL2B SPRR2E SPTBN2 SREBF1 SRPRB SSPO SSR2 ST3GAL5 ST6GALNAC4 ST6GALNAC6 STARD5 SUSD2 SUSD3 SYP SYT5 SYTL1 SYVN1 TAC3 TAPBPL TAS1R3 TBC1D10C TBKBP1 TCF7 TCL6 TENC1 TFEB TFPT THBS3 THRSP TIAF1 TIE1 TLR9 TM7SF2 TMC8 TMCC2 TMED2 TMEM129 TMEM150A TMEM198 TMEM205 TMEM38A TMEM52 TMPRSS13 TNFRSF13C TNFRSF17 TNFRSF25 TNFRSF6B TNFSF8 TNK2 TNS4 TP53I3 TP53INP1 TPCN1 TRIM46 TSC22D4 TSPAN15 TSPAN4 TTC21A TUBB2B UBE2J1 UCP2 UNC13D USHBP1 USP32P1 USP32P2 VIPR2 VPREB1 WBSCR17 XPA XRCC6BP1 YJEFN3 ZDHHC11 ZMIZ2 ZNF362 ZNF37BP ZNF385A ZNF485 ZNF692 ZSCAN30

KEGG genes in the Epstein-Barr virus infection pathway

Flu / Cold / SARS news headlines provided courtesy of Medical News Today.

 

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Last update: September 12, 2017

 

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