Enhanced links are provided by Diverse Kegg pathway analysis of GWAS and other networks
Virus Pathogen Resource: VIPR Ebolavirus CDC Center for diseases control Expasy Viral Zone      

UCSC Ebola Genome Portal

EDB Ebola database

Host pathogen interactomes for :Bornavirus; Borrelia Burgdorferi; Candida albicans; Chlamydia Pneumoniae ; Cryptococcus Neoformans; Epstein-Barr virus; Helicobacter pylori; Hepatitis C virus; Herpes simplex (HSV-1); HERV-W; HIV-1, Human Protein Interaction Database (NCBI); Human cytomegalovirus; Influenza A virus; Porphyromonas Gingivalis; Toxoplasma Gondii; Trypanosoma Cruzi : KEGG pathway analysis of these interactomes can be accessed here  

 

 

Host proteins used by the Ebolavirus during its life cycle.

If you know of other interactions, (or corrections) please with Pubmed ID, gene symbol/accession number and interacting protein. Thank you.

KEGG pathways for this interactome can be found HERE

  1. ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase: regulates viral replication Garcia et al, 2012
  2. ADAM17 ADAM metallopeptidase domain 17 (tace): cleaves the viral glycoprotein Dolnik et al, 2004
    1. This shed form binds and activates non-infected dendritic cells and macrophages and induces the secretion of pro- and anti-inflammatory cytokines TNF, IL1B, IL6, IL8, IL12B, IL1RN and IL10 Escudero-Pérez et al, 2014
  3. AHCY adenosylhomocysteinase: Inhibitors block viral replication Huggins et al, 1999
  4. AKT1 v-akt murine thymoma viral oncogene homolog 1 : inhibition inhibits entry of viral particles Saeed et al, 2008
  5. AP-2 (multimeric complex of AP2A1 AP2A2 AP2B1 AP2M1 AP2S1) viral entry requires the cargo recognition proteins Eps15 and DAB2 as well as the clathrin adaptor protein AP-2 Bhattacharyya et al, 2011.
  6. ARF1 ADP-ribosylation factor 1: involved in Ebolavirus virion formation Yamayoshi et al, 2010
  7. AXL AXL receptor tyrosine kinase: Involved in viral entry Shimojima et al, 2006
  8. BST2 bone marrow stromal cell antigen 2 (tetherin) : inhibits retroviral and filoviral ( Marburg virus and Ebola virus) particle release Jouvenet et al, 2009
  9. C1QBP mediates MBL-dependent enhancement of viral infection Brudner et al, 2013.
  10. Calcium: Intracellular calcium regulates viral budding Han and Harty, 2007
  11. CANX calnexin: involved in folding of the glycoproteins of many enveloped viruses, including the filoviruses Chang et al, 2013
  12. CASP8 caspase 8: downregulated in viral glycoprotein-expressing human umbilical vein endothelial cells Sheng et al, 2014
  13. CCL2 chemokine (C-C motif) ligand2 (MCP-1) : direct infection of human peripheral blood mononuclear cells results in the induction of MCP-1, MIP-1alpha, RANTES, and TNF-alpha as early as 24 h p.i. in response to live virus Gupta et al, 2001
  14. CCL3 chemokine (C-C motif) ligand 3 (MIP 1 alpha): Gupta et al, 2001
  15. CCL5 chemokine (C-C motif) ligand 5 : (RANTES) Gupta et al, 2001
  16. CD44 molecule (Indian blood group): increase in expression in mouse CD4(+) and CD8(+) T cells late in infection, preceding a dramatic rebound of lymphocyte numbers in the blood (after pronounced lyphocyte apoptosis) Bradfute et al, 2008.
  17. CD209 CD209 molecule (DC-SIGN) : C-type lectins DC-SIGN and L-SIGN mediate cellular entry by Ebola virus in cis and in trans Alvarez et al, 2002
  18. CFLAR CASP8 and FADD-like apoptosis regulator: downregulated in viral glycoprotein-expressing human umbilical vein endothelial cells Sheng et al, 2014
  19. CLEC4G C-type lectin domain family 4, member G : Viral receptor Domínguez-Soto et al, 2009
  20. CLEC4M C-type lectin domain family 4, member M (L-SIGN): C-type lectins DC-SIGN and L-SIGN mediate cellular entry by Ebola virus in cis and in trans Alvarez et al, 2002
  21. CLEC6A C-type lectin domain family 6, member A : candidate viral attachment factor Brudner et al, 2013
  22. CLTC clathrin, heavy chain (Hc): Ebola virus uses clathrin-mediated endocytosis as an entry pathway Bhattacharyya et al, 2010.
  23. CTBP1 C-terminal binding protein 1: Inhibition inhibits viral cellular entry Saeed et al, 2010
  24. CTSB: Cathepsins B and L activate Ebola but not Marburg virus glycoproteins for efficient entry into cell lines and macrophages Gnirss et al, 2012
  25. CTSL cathepsin L: Cathepsins B and L activate Ebola but not Marburg virus glycoproteins for efficient entry into cell lines and macrophages Gnirss et al, 2012
  26. Cyanovirin-N produced by cyanobacteria binds to the viral surface glycoprotein, GP1,2 and inhibits viral infectivity Barrientos et al, 2003.
  27. Cytokine storms: fatal outcome in infected humans associated with hypersecretion of numerous proinflammatory cytokines (IL1B, IL1RN, IL6, IL8, IL15 and IL16), chemokines and growth factors (CCL2, CCL3, CCL4, CCL11, CSF1, MIF, CXCL1, CXCL10) Wauquier et al, 2010
  28. DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 : viral entruy requires the cargo recognition proteins Eps15 and DAB2 as well as the clathrin adaptor protein AP-2 Bhattacharyya et al, 2011.
  29. DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1): downregulated in viral glycoprotein-expressing human umbilical vein endothelial cells Sheng et al, 2014
  30. DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58: VP35 blocks activation of IRF-3 induced by overexpression of RIG-I (DDX58),Cárdenas et al, 2006
  31. DICER1 dicer 1, ribonuclease type III viral VP30 interacts with Dicer independently of siRNA and with one Dicer partner, TARBP2, only in the presence of siRNA Fabozzi et al, 2011
  32. DNM2 dynamin 2: Involved in viral cellular entry Aleksandrowicz et al, 2011
  33. DYNLL1 dynein, light chain, LC8-type 1: Binds to viral VP35 Kubota et al, 2009
  34. EIF2A eukaryotic translation initiation factor 2A, 65kDa: phosphorylation of PKR and eIF-2alpha suppressed in cells expressing the VP35 protein Feng et al, 2007.
  35. EIF5A eukaryotic translation initiation factor 5A: activated EIF5A required for viral replication Olsen et al, 2016
  36. EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 (pkr): Inhibited by viral vp35 Feng et al, 2007
  37. EMILIN1 elastin microfibril interfacer 1 : Interacts with viral glycoprotein 1Veljkovic et al, 2015
  38. EMILIN2 elastin microfibril interfacer 2: ""
  39. EMILIN3 elastin microfibril interfacer 3:""
  40. EPS15 epidermal growth factor receptor pathway substrate 15: dominant-negative Eps15blocks infection Bhattacharyya et al, 2010
  41. EXT1 exostosin glycosyltransferase 1: siRNA knockdown of EXT1 impairs GP-mediated pseudoviral entry and that of infectious Ebolaand Marburb viruses in tissue cultured cells O'Hearn et al, 2015.
  42. F3 coagulation factor III (thromboplastin, tissue factor): plays an important role in triggering the hemorrhagic complications that characterize ebola virus infections Geisbert et al, 2003
  43. F7 coagulation factor VII (serum prothrombin conversion accelerator):Plasma levels decreased in infected monkeys from 1 days post-infection Geisbert et al, 2003
  44. FAM134B inhibits viral replication Chiramel et al, 2016
  45. FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b: the secreted viral glycoprotein interacts with neutrophils via CD16b Yang et al, 1998
  46. FCN1 Ficolin1: enhances viral replication Favier et al, 2016
  47. Fibrin deposition in infected monkeys from day 2 post-infection closely associated with the viral antigen (from fibrinogen(s) cleavage (FGA FGB FGG ) Geisbert et al, 2003
  48. FOLR1 folate receptor 1 (adult): cofactor for cellular entry for marburg and ebola viruses Chan et al, 2001
  49. FURIN furin (paired basic amino acid cleaving enzyme)I. processes the viral glycoprotein Volchkov et al, 1998
  50. GANAB glucosidase, alpha; neutral AB : Host cellular endoplasmic reticulum a-glucosidases I and II are essential for the maturation of viral glycosylated envelope proteins that use the calnexin mediated folding pathway (including Ebola) Chang et al, 2013. endoplasmic reticulum alpha glucosidases include GAA GABAB GANC and MOGS
  51. GAS6 growth arrest-specific 6 : Axl/Gas6, as well as other phosphatidylserine receptors, facilitate entry of dengue, West Nile, and Ebola viruses Morizono and Chen 2014.
  52. GBF1 golgi brefeldin A resistant guanine nucleotide exchange factor 1 : involved in Ebolavirus virion formation Yamayoshi et al, 2010
  53. GSK3B glycogen synthase kinase 3 beta: phosphorylates the antiviral protein ZC3HAV1 (active against HIV-1, Ebola, Marburg and Sindbis virus.) and GSK3B inhibition decreases its antiviral activity Sun et al, 2012
  54. KPNA5 karyopherin alpha 5 (importin alpha 6): Binds to viral VP24 Xu et al, 2014
  55. HAVCR1 hepatitis A virus cellular receptor 1 (Tim-1): phosphatidylserine binding residues of the TIM-1 IgV domain are critical for Ebola virus entry via direct interaction with phosphatidylserine on the viral envelope Moller-Tank et al, 2013.
  56. HAVCR2 hepatitis A virus cellular receptor 2: (Tim-3): TIM-1, TIM-3 and TIM-4 block the release of HIV-1, as well as that of murine leukemia virus and Ebola virus Li et al, 2014
  57. Heparan sulfate: heparan sulfate, heparin, and other related glycosaminoglycans , to different extents, can bind to and block GP-mediated viral entry and that of infectious filoviruses. O'Hearn et al, 2015.
  58. HMOX1 heme oxygenase (decycling) 1 : suppresses viral replication Hill-Batorski et al, 2013
  59. HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) : binds to viral vp24 Shabman et al, 2011
  60. HSPA8 Heat shock protein family A (Hsp70) member 8: interacts with the viral trailer Sztuba-Solinska et al, 2016
  61. ICAM1 Induction of the major histocompatibility complex class I family of genes, 2'-5'(A)N, interleukin-6 (IL-6), PKR, interferon (IFN)-regulatory factor-1, and intercellular adhesion molecule-1 (ICAM-1) by dsRNA in human umbilical vein endothelial cells is suppressed by infection with the filovirus Ebola-Zaire Harcourt et al, 1998
  62. IFITM1 interferon induced transmembrane protein 1 (also IFITM2 IFITM3) IFITM proteins restrict infection mediated by the entry glycoproteins (GP(1,2)) of Marburg and Ebola filoviruses Huang et al, 2011
  63. IFNA1 interferon, alpha 1 : Viral VP35 inhibits interferon alpha and beta production induced by TLR3 or TLR4 agonists Yen et al, 2014
  64. IFNB1 interferon, beta 1, fibroblast: Viral VP35 inhibits interferon alpha nd beta production induced by TLR3 or TLR4 agonists Yen et al, 2014
  65. IFNG interferon, gamma: High serum levels in infected patients Villinger et al, 1999
  66. IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon: binds to VP35 Prins et al, 2009
  67. IL1B interleukin 1, beta : The shed viral glycoprotein binds and activates non-infected dendritic cells and macrophages inducing the secretion of pro- and anti-inflammatory cytokines (TNF, IL1B, IL6, IL8, IL12B, and IL1RN, IL10) Escudero-Pérez et al, 2014.
  68. IL1RN Interleikin 1 receptor antagonist : Knockout enhances susceptibility to infection Hill-Batorski et al, 2015
  69. IL2 interleukin 2: High serum levels in infected patients Villinger et al, 1999
  70. IL4 interleukin 4 Increased levels of IL6, TNF-alpha, IFN-gamma, IL2, IL4, IL8, IL10, and GM-CSF were detected in infected monkeys Hutchinson et al, 2001
  71. IL6 interleukin 6: The shed viral glycoprotein binds and activates non-infected dendritic cells and macrophages inducing the secretion of pro- and anti-inflammatory cytokines (TNF, IL1B, IL6, IL8, IL12B, and IL1RN, IL10) Escudero-Pérez et al, 2014.
  72. IL8 interleukin 8 (CXCL8): The shed viral glycoprotein binds and activates non-infected dendritic cells and macrophages inducing the secretion of pro- and anti-inflammatory cytokines (TNF, IL1B, IL6, IL8, IL12B, and IL1RN, IL10) Escudero-Pérez et al, 2014.
  73. ILF3 interleukin enhancer binding factor 3, 90kDa : binds to viral VP35 Shabman et al, 2011
  74. IQGAP1 IQ motif containing GTPase activating protein 1: Binds to VP40 Lu et al, 2013
  75. IRF3 interferon regulatory factor 3: viral VP35 blocks virus-induced IRF-3 phosphorylation and subsequent IRF-3 dimerization and nuclear translocation Basler et al, 2003
  76. IRF7 interferon regulatory factor 7: viral VP35 interacts with IRF7, UBE2I and PIAS1 Chang et al, 2009
  77. ITCH Itchy E3 ubiquitin protein ligase: interacts with viral evp40 Han et al, 2016
  78. ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) : alpha(5)beta(1)-integrin is required for efficient infection by pseudovirions bearing the ebolavirus glycoprotein Schornberg et al, 2009.
  79. ITGAM integrin, alpha M (complement component 3 receptor 3 subunit): the secreted viral glycoprotein alters the physical linkage between FCGR3B and CR3 Kindzelskii et al, 2000.
  80. ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12): alpha(5)beta(1)-integrin is required for efficient infection by pseudovirions bearing the ebolavirus glycoprotein Schornberg et al, 2009.
  81. ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) : the secreted viral glycoprotein alters the physical linkage between FCGR3B and CR3 Kindzelskii et al, 2000.
  82. ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) : The viral glycoprotein downregulates ITGA5/ITGB3 in endothelial cells Sullivan et al, 2005
  83. KPNA1 karyopherin alpha 1 (importin alpha 5): The ability of hnRNP C1/C2 to bind KPNA1 is diminished in the presence of viral VP24, Shabman et al, 2011
  84. KPNA5 karyopherin alpha 5 (importin alpha 6): Viral VP24 inhibits interaction of phosphorylated STAT1 with karyopherins alpha1, alpha5, or alpha6 by binding within the P-STAT1 binding region of the karyopherins Reid et al, 2007
  85. KPNA6 karyopherin alpha 6 (importin alpha 7) : Viral VP24 inhibits interaction of phosphorylated STAT1 with karyopherins alpha1, alpha5, or alpha6 by binding within the P-STAT1 binding region of the karyopherins Reid et al, 2007
  86. MAP2K1 mitogen-activated protein kinase kinase 1 (MEK1) phosphorylated by infection in hepatocytes Kindrachuk et al, 2014
  87. MAP3K8 mitogen-activated protein kinase kinase kinase : activated by viral VP35 Gantke et al, 2013
  88. MAPK1 mitogen-activated protein kinase 1: VP24 blocks IFN-ß-stimulated phosphorylation of MAPK1 Halfmann et al, 2011
  89. MAPK8 mitogen-activated protein kinase 8: phosphorylated by infection in hepatocytes Kindrachuk et al, 2014
  90. MBL2 mannose-binding lectin (protein C) 2, soluble: shed viral glycoprotein activity is negated by addition of MBL2, a molecule known to interact with sugar arrays present on the surface of different microorganisms Escudero-Pérez et al, 2014.
  91. MERTK MER proto-oncogene, tyrosine kinase: expression of MERTK, integrin ITGA5, and NPC1 are required for viral glycoprotein-mediated transduction and infection of macrophages Dahlmann et al, 2015.
  92. MIR1246 microRNA 1246: microRNAs hsa-miR-1246, hsa-miR-320a and hsa-miR-196b-5p were induced in human umbilical vein endothelial cells following expression of the viral glycoprotein Sheng et al, 2014.
  93. MYD88 myeloid differentiation primary response 88 : viral particles trigger host responses through toll-like receptor pathway utilizing 2 distinct adaptors, MyD88 and TICAM1 (TRIF). Ayithan et al, 2014
  94. NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase: plays a role in viral budding and egress Yasuda et al, 2003
  95. NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 : activated by the virus in dendritic cells Martinez et al, 2007
  96. NPC1 Niemann-Pick disease, type C1 : Binds the viral glycoprotein Lee et al, 2013
  97. ORAI1 ORAI calcium release-activated calcium modulator 1: expression of matrix proteins from both filoviruses and arenaviruses triggers an increase in host cytoplasmic Ca2+ concentration by a mechanism that requires host Orai1 channels Han et al, 2015
  98. OSBPL1A oxysterol binding protein-like 1A (orp1L): RILP and ORP1L control Ebola virus infection at the level of late endosomal fusion van der Kant et al, 2013.
  99. PAK1 p21 protein (Cdc42/Rac)-activated kinase 1: Inhibition inhibits viral cellular entry Saeed et al, 2010
  100. PARP1 poly (ADP-ribose) polymerase 1: Cleaved during a necrotic (not apoptotic) pathway induced by the virus Olejnik et al, 2013
  101. PCSK5 proprotein convertase subtilisin/kexin type 5: Recombinant enzyme cleaves peptides from the viral glycoprotein Basak et al, 2001
  102. PCSK7 proprotein convertase subtilisin/kexin type 7 : Recombinant enzyme cleaves peptides from the viral glycoprotein Basak et al, 2001
  103. PDCD6IP programmed cell death 6 interacting protein (alix); : interacts with viral VP40 Han et al, 2015
  104. PDPK1 3-phosphoinositide dependent protein kinase 1: phosphorylated by infection in hepatocytes Kindrachuk et al, 2014
  105. Phosphatidylserine regulates the assembly and budding of the Ebola Virus Adu-Gyamfi et al, 2015.
  106. PIAS1 protein inhibitor of activated STAT, 1 : viral VP35 interacts with IRF7, UBE2I and PIAS1 Chang et al, 2009
  107. PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha): dominant negative inhibits entry of viral particles Saeed et al, 2008
  108. Phosphatidyl 4,5 diphosphate PI(4,5)P2 stabilises or induced VP40 oligomerisation Johnson et al, 2016
  109. PLAT plasminogen activator, tissue: Plasma levels increased in infected monkeys from 3 days post-infection Geisbert et al, 2003
  110. PLAU plasminogen activator, urokinase: Plasma levels increased in infected monkeys from 3 days post-infection Geisbert et al, 2003
  111. PRF1 perforin 1 (pore forming protein): clearance of Ebola virus is perforin-dependent Gupta et al, 2005
  112. PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit: Mouse embryonic fibroblasts lacking the AMPKa1 and AMPKa2 catalytic subunits were significantly less permissive to EBOV GP-mediated infection Kondratowicz et al, 2013
  113. PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit: Mouse embryonic fibroblasts lacking the AMPKa1 and AMPKa2 catalytic subunits were significantly less permissive to EBOV GP-mediated infection Kondratowicz et al, 2013
  114. PRKRA protein kinase, interferon-inducible double stranded RNA dependent activator : Viral VP35 directly interacts with Dicer partners TRBP and PRKRA Fabozzi et al, 2011
  115. PROC protein C (inactivator of coagulation factors Va and VIIIa): rapid decrease in plasma levels following ebola virus infections Geisbert et al, 2003
  116. PTPRC protein tyrosine phosphatase, receptor type, C: mice expressing reduced levels of this tyrosine phosphatase (aka CD45) are protected against EBOV, whereas wild-type, CD45-deficient, or enzymatically inactive CD45-expressing mice succumbed to infection Panchal et al, 2009.
  117. RAB1B RAB1B, member RAS oncogene family : involved in Ebolavirus virion formation Yamayoshi et al, 2010
  118. RAB7A, member RAS oncogene family: Ebolavirus particles co-localize with RAB7 Nanbo et al, 2010.
  119. RAB9A, member RAS oncogene family: required for viral replication Murray et al, 2005
  120. RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1): inhibition of PI3K, Akt, or Rac1 disrupted normal uptake of virus particles into cells Saeed et al, 2008
  121. RILP Rab interacting lysosomal protein: RILP and ORP1L control Ebola virus infection at the level of late endosomal fusion van der Kant et al, 2013.
  122. SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae): binds to viral vp24 Iwasa et al, 2011
  123. SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal : Required for infection Miller et al, 2012
  124. SNX5 sorting nexin 5: Ebolavirus particles co-localize with SNX5, a marker of macropinocytosis-specific endosomes (macropinosomes) Nanbo et al, 2010.
  125. SOCS1 suppressor of cytokine signaling 1 : activated by TLR4 signalling in infected cells Okumura et al, 2010
  126. Sphingomyelin: plasma membrane sphingomyelin is needed for infection Miller et al, 2012
  127. SRM spermidine synthase: knochdown reduces viral replication Olsen et al, 2016
  128. STAT1 signal transducer and activator of transcription 1, 91kDa : viral VP24 protein binds KPNA5 to inhibit phosphorylated STAT1 nuclear transport and render cells refractory to interferons Xu et al, 2014
  129. STIM1 stromal interaction molecule 1: suppression of STIM1 (which triggers Orai activation) and genetic inactivation or pharmacological blockade of Orai1 channels inhibits virus-like particle and infectious virus egress. Han et al, 2015
  130. TBK1 TANK-binding kinase 1: binds to VP35 Prins et al, 2009
  131. TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) : downregulated in viral glycoprotein-expressing human umbilical vein endothelial cells Sheng et al, 2014
  132. TGFB1 transforming growth factor, beta 1: Upregulated by infection in hepatocytes Kindrachuk et al, 2014
  133. TICAM1 toll-like receptor adaptor molecule 1: viral particles trigger host responses through toll-like receptor pathway utilizing 2 distinct adaptors, MyD88 and TICAM1 (TRIF). Ayithan et al, 2014
  134. TIMD4 T-cell immunoglobulin and mucin domain containing 4: TIM-1, TIM-3 and TIM-4 block the release of HIV-1, as well as that of murine leukemia virus and Ebola virus Li et al, 2014
  135. TLR4 toll-like receptor 4 : involved in the viral shed glycoprotein activation af dendritic cells and macrophages and secretion of pro- and anti-inflammatory cytokines TNF, IL1B, IL6, IL8, IL12B, IL1RN and IL10 Escudero-Pérez et al, 2014
  136. TNF tumor necrosis factor: direct infection of human peripheral blood mononuclear cells results in the induction of MCP-1, MIP-1alpha, RANTES, and TNF-alpha as early as 24 h p.i. in response to live virus Gupta et al, 2001
  137. TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 (Trail) : nRNA upregulation in CD4 and CD8 T cells on day 7 post-infection (related to lymphocyte death) Gupta et al, 2007
  138. TOP1 topoisomerase (DNA) I: binds to Ebola virus protein L Takahashi et al, 2013
  139. TPCN1 two pore segment channel 1: virus entry into host cells requires endosomal two-pore calcium channels Sakurai et al, 2015
  140. TPCN2 two pore segment channel 2 : virus entry into host cells requires endosomal two-pore calcium channels Sakurai et al, 2015
  141. TSG101 tumor susceptibility 101: Viral VP40 and tsg101 interaction involved in viral budding Licata et al, 2003
  142. TYRO3 TYRO3 protein tyrosine kinase: Involved in viral entry Shimojima et al, 2006
  143. UBE2I ubiquitin-conjugating enzyme E2I: viral VP35 interacts with IRF7, UBE2I and PIAS1 Chang et al, 2009
  144. VPS4A vacuolar protein sorting 4 homolog A (S. cerevisiae): viral VP40 can redirect VPS4, VPS28, and VPS37B from endosomes to the cell surface independently of TSG101 interaction Silvestri et al, 2007
  145. VPS4B vacuolar protein sorting 4 homolog B (S. cerevisiae) see above Silvestri et al, 2007 .
  146. ZC3HAV1 zinc finger CCCH-type, antiviral 1 : acts against the Ebola virus and Marburg virus Müller et al, 2007
  147. Zinc binds to the viral VP30 protein Modrof et al, 2003

    High throughput experiments

    The temporal program of peripheral blood gene expression in the response of nonhuman primates to Ebola hemorrhagic fever Rubins et al, 2007

    Whole-Genome Expression Profiling Reveals That Inhibition of Host Innate Immune Response Pathways by Ebola Virus Can Be Reversed by a Single Amino Acid Change in the VP35 Protein Hartman et al, 2008

    genes unique to cells infected with recEbo-VP35/WT virus.EBI3 MTND4L PXDNL RASSF1 SF1 SLC16A11
    genes unique to cells infected with recEbo-VP35/R312A virus.BIRC3 CCL5 DKFZP434D193 ENOSF1 EXOC8 FSIP2 GADD45GIP1 GMCL1 HELZ2 HERC5 IFI27 IFIH1 IFIT1 IFIT2 ISG15 ISGF3G KIAA1524 KRT17 MOBKL1A MX1 OAS1 OFD1 OR5QS1 OSTCP1 PLSCR1 PPFIBP1 RCHY1 REC8L1 SENP7 SLC43A3 STAT1 TAPT1 TLK1 TMSL2 TPT1P4 WDR51B ZFP90

    genes common to cells infected with both recEbo-VP35/WT and recEbo-VP35/R312A viruses. ARID1B DNAAF2 CENPQ CASP6 CAV2 CD184 CDC10 CFAP36 CML2 COX7A3 CTNNA1 DKFZP76181514 DOC1 DUSP6 FGFR10P FGG PPCS HIF1A HNRNPK HSPB1P2 IFP38 KIAA1604 LOC283970 LOC286177 LOC342405 LOC343363 LOC374744 LOC374811 LOC375172 LOC375528 LOC377296 LOC377524 LOC377527 LOC377653 LOC389974 LOC401028 LOC401900 LUC7A MRPL47 MRPS10 MTND4L N2N NARF OSBPL9 PCDH89 QDPR REEP2 RPL18AP4 RPL29P31 RPL9 RPLP1P5 SDC2 SEPT10 SFRS12 SLC19A2 SMN1 SNAP23 SNAPC1 STCH STXBP3 TADA3L TANK TM4SF1 TNXL

    Identification of novel cellular targets for therapeutic intervention against Ebola virus infection by siRNA screening Kolokoltsov et al, 2009.

    MAP kinase pathway genes: ALS2CR2 ERN2 MAP2K3 MAP3K10 MAP3K11 MAP3K12 MAP3K13 MAP3K2 MAP3K3 MAP3K4 MAP3K5 MAP3K7 MAP3K9 MAP4K2 MAPK10 MAPK12 MAPK13 MAPK8IP1 MAPK8IP2 MKNK1 MKNK2 STK4

    pi3 kinase signalling: AKT1 FRAP4 JAK1 JAK2 JAK3 MET PDGF PDGFRB PIK3C3 PIK3R1 PIK3R2 PIK3R4 PRKCD PRKCZ ROS1 TEK TYK2 TYRO3

    Calcium/calmodulin signalling: AKAP AKAP4 AKAP5 CALM2 CAMK1 CAMK1D CAMK1G CAMK1G CAMK2B CASK CDK7 CDK8 CDK9 ITPKA PRKAGA PRKAR1B TTN

    Identification of essential filovirion-associated host factors by serial proteomic analysis and RNAi screen Spurgers et al, 2010.

  • Host proteins identified in ebola virions by LC-MS/MS.
  • A2M ACTB ACTG1 ACTN1 ACTN4 ANXA2 ANXA4 ANXA5 ARF1 ARF6 ATP1A1 ATP5A1 CFL1 CLDN1 CLDN3 DCD DNAJB2 FAM125AGGT1 GGT3 GLUD2 GNB2 GNB2L1 GPC4 GRB2 HIST1H2BO HIST2H4A HLA-C HSP90AA1 HSP90AB1 HSPA1A HSPA1L HSPA5 HSPA8 HSPB1 ITGA3 KIAA1529 LDHA MLF2 NTRK1 PDIA4 PFN1 PKM2 PLG PLTP RAB11B RAB5C RAN RPL18 RPL3 RPL5 RPS6 TAGLN2 TRAP1 TSG101 TUBA1A UBC UBE2N VCP VIM VPS28 VTN YWHAG YWHAQ YWHAZ
  • Elucidation of the Ebola virus VP24 cellular interactome and disruption of virus biology through targeted inhibition of host-cell protein function García-Dorival et al, 2014
    • VP24 binding partners include:- ANP32A ANP32B ATP1A1 ATP2A2 BSG CAD CCAR2 CCT5 CCT7 CGGBP1 CHD4 COX5B DNAJA1 EHD4 EMD FAF2 GNB2 HIST1H1E HNRNPL HNRNPU HSP90AB1 HSPA1A HSPA8 KIAA1967 KPNA1 KPNA6 LMNB1 MYO5A PCNA PGRMC1 PHB PHGDH POM121C PRKCSH PRKDC RAB11A RAB7A RBBP4 RCC2 RCN2 RPL22 RPN1 RPN2 RPS17 RPS20 RPS27 RPS27L RPS3 SLC1A5 SLC25A3 SLC25A5 SLC3A2 SRPRB SSR3 SSR4 TCP1 TMED10 TRIM28 TUB1C TUBB TUFM UQRCH VDAC1 VDAC2 YME1L1
  • Functional genomics reveals the induction of inflammatory response and metalloproteinase gene expression during lethal Ebola virus infection Cilloniz et al, 2011.
    • Regulated genes in spleen samples of infected mice
    • C5AR1 CCL2 CCL7 CHI3L1 CLEC4D CLEC4E CSF2 CSF3 CSTA CXCL1 CXCL2 CXCL5 DHRS9 ENTPD3 GDF15 GPR84 GZMC HDC HP IL1F9 IL1R2 IL1RN IL6 IRG1 MMP3 MMP8 MMP9 MRGPRA2 MSR1 PTGS2 RETNLG SAA1 SAA3 SERPINE1 STEAP1 STFA2 TIMP1 TREM1 VCAN
    • genes associated with lethality 2810004N23RIK 4930557B21RIK 4931429I11RIK A530099J19RIK ADAM23 ADAMDEC1 ADORA2B ARG2 ARVCF ASPRV1 CD209B CDKN1A CILP CIRBP CLEC4D CLEC4E COL4A1 CP CPNE4 CREM CSF2RB CX3CR1 EDAR FCER2A FXYD2 GM6462 HSP90B1 HSPE1 IL13RA1 IL1RN KAZALD1 LIMCH1 LITAF LRRC4C MLC1 MMP19 MMP3 MSR1 NAIP1 PARK2 PARVA PCP4 PLA2G2D PTAFR RAET1A RBM9 RHOF RXRG SERPINH1 SHISA3 SHMT1 SOD2 STEAP4 TIMD4 TIMP1 TUBB6 ZC3H6



  • DNA Topoisomerase 1 Facilitates the Transcription and Replication of the Ebola Virus Genome: Takahashi et al, 2013
  • Proteins binding to Ebola virus protein L
  • ACTA1 AP2B1 ATAD3C ATP5C1 BAG2 BCLAF1 CAMSAP3 CAPRIN1 CCT7 CDC5L CHD4 CHD9 DDX18 DNAJA1 DNAJA2 DNAJA3 DYNLL1 EBNA1BP2 EIF2S3 EIF5B FBL GRSF1 H3F3A HIST1H1C HNRNPA0 HNRNPDL HNRNPF ILF3 LARP1 LUC7L LUC7L3 LYAR MAPKAPK2 MRPS35 MTDH NUTM2F PGAM5 PPP2R1A PPP2R2A PRDX1 PSIP1 PSMD6 PTBP3 RBM15 ROCK1 RRP1B RSL1D1 SEC61B SLC25A3 SNRNP200 SNRPB SNRPC SNRPE SRBD1 SRSF4 ST7 SYNCRIP TOP1 TOP2A TUBA1B TUBB4A TUBB6 TUFM VIM YTHDC2
  • Ebola virus modulates transforming growth factor ß signaling and cellular markers of mesenchyme-like transition in hepatocytes. Kindrachuk et al, 2014
    • Kinome responses to infection ARAF BAX BCL2 BID BRAF CDH1 CDK1 CDK4 CDKN1B CHUK EGFR FLT1 FOS GIT2 HCK JUN KIT LIMK1 LYN MAP2K2 MAP2K4 MDM2 MTOR NFATC2 PAK2 PAK4 PIK3R1 PRKACA PTEN PTK2 PTK2B PXN RELA RHOA RPS6KB1 SHC1 SHC3 SMAD1 SMAD2 STAT5B SYK TAB1 TGFBR1 TGFBR2 TRAF2 YWHAZ



 
     

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Last update: October 21, 2016