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Host proteins used by Cryptococcus Neoformans during its life cycle.

If you know of other direct interactions, (or corrections) please with Pubmed ID, gene symbol/accession number and viral interacting protein. Thank you.

 

  1. ATG2A autophagy related 2A: Atg2a, Atg5, Atg9a, Atg12 and MAP1LC3A (LC3) RNA silencing in murine RAW264.7 macrophages decreases C.Neoformans uptake or replication Qin et al, 2011
  2. ATG5 autophagy related 5 : ATG5-knockout bone marrow-derived macrophages had decreased fungistatic activity against C. neoformans when activated. In contrast, nonactivated ATG5-knockout BMMs restricted C. neoformans growth Nicola et al, 2012
  3. ATG9A autophagy related 9A: Atg2a, Atg5, Atg9a, Atg12 and LC3 RNA silencing in murine RAW264.7 macrophages decreases C.Neoformans uptake or replication Qin et al, 2011
  4. BTK Bruton tyrosine kinase: Higher infection in BTK mutant mice Szymczak et al, 2013
  5. CARD9 caspase recruitment domain family member 9: CARD9 KO mice are susceptible to C. neoformans infection Yamamoto et al, 2014
  6. CASP1 Caspase 1: Internalized Cryptococcus neoformans activates CASP1 and CASP8 inflammasomes Chen et al, 2015
  7. CASP8Caspase 8: Internalized Cryptococcus neoformans activates CASP1 and CASP8 inflammasomes Chen et al, 2015
  8. CAV1 caveolin 1 : plays an essential role in C. neoformans traversal of the blood-brain barrier.Long et al, 2012
  9. CCL1 C-C motif chemokine ligand 1(P500; SISe; TCA3; I-309; SCYA1): plays a role in protection against Cryptococcus neoformans in the lungs and brains of infected mice Doyle and Murphy,1999
  10. CCL2 C-C motif chemokine ligand 2: (HC11; MCAF; MCP1; MCP-1; SCYA2; GDCF-2; SMC-CF; HSMCR30) C. neoformans induces CCL2 release from monocytes Levitz et al, 1997
  11. CCL3 C-C motif chemokine ligand 3 (MIP1A; SCYA3; G0S19-1; LD78ALPHA; MIP-1-alpha): required for the efferent phase of pulmonary cell-mediated immunity to infection Huffnagle et al, 1997.
  12. CCL4 C-C motif chemokine ligand 4: Cryptococcus neoformans induces CCL3 and CCL4 in human microglia Goldman et al, 2001
  13. CCL5 C-C motif chemokine ligand 5: CCL3,4 and 5 expression and/or release increased in infected human peripheral blood mononuclear cells Huang and Levitz, 2000
  14. CCL7 promotes the development of robust immunity to cryptococcal infection Qiu et al, 2012.
  15. CCR2 mediates dendritic cell recruitment to infected mice lungs Osterholzer et al, 2008
  16. CCR4 promotes resolution of the endoplasmic reticulum stress response during host temperature adaptation in Cryptococcus neoformans Havel et al, 2008.
  17. CCR5 and CCR2 are required for leukocyte recruitment and for other aspects of immune response development and innate imunity to C. neoformans Huffnagle et al, 2000.
  18. CD5 molecule : CD5 ectodomain binds to and aggregates fungal cells (Schizosaccharomyces pombe, Candida albicans, and Cryptococcus neoformans) but not to Gram-negative (Escherichia coli) or Gram-positive (Staphylococcus aureus) bacteria Vera et al, 2009
  19. CD14 Fungal glucuronoxylomannan binds to CD14 in human A549 alveolar cells inducing interleukin-8 production Barbosa et al, 2014
  20. CD36 molecule: SCARF1 and CD36, mediate host defense against C.neoformans and Candida albicans Means et al, 2009
  21. CD44 molecule (Indian blood group) : involved in infection of brain microvascular endothelial cells Jong et al, 2008.
  22. CD209 (DC-sign) Cryptococcus neoformans glycoantigens are captured by multiple lectin receptors including MRC1 (CD206) and CD209 and presented by dendritic cells Mansour et al 2006
  23. CDC42 cell division cycle 4: Cryptococcus activates RhoA, Rac1, and Cdc42, and this isrequired for cryptococcal transmigration across human brain microvascular endothelial cells Kim et al, 2012
  24. CFL1 Cofilin: the dephosphorylated form of cofilin increases during cryptococcal adherence to human brain microvascular endothelial cells Chen et al, 2003
  25. CHRNA7 blood brain barrier injury significantly reduced in CHRNA7(-/-) mice infected with C. neoformans Zhang et al, 2015
  26. CLEC4D C-type lectin domain family 4 member D: The anticryptococcal activity of murine dendritic cells relates to CLEC4D Hole et al, 2016
  27. CLEC6A C-type lectin domain family 6 member A: (Dectin-2) may oppose the Th2 response and IL-4-dependent mucin production in the lungs after infection with C. neoformans Nakamura et al, 2015
  28. CLEC7A C-type lectin domain family 7 member A (Dectin 1): fungal beta-(1,3)-glucan interacts with host receptors Dectin-1 and ITGAM/ITGB2.Giles et al, 2009:
  29. CR1 complement component 3b/4b receptor 1 (Knops blood group): Macrophages bind and phagocytose opsonized C. neoformans via three major complement receptors CR1, ITGB2/ITGAM , and ITGB2/ITGAX Levitz, 2002
  30. CSF2 colony stimulating factor 2 (gm-csf) : IL2 and CSF2 are capable of stimulating human peripheral blood mononuclear cells-mediated antifungal activity Collins and Bancroft, 1992
  31. CYSLTR1 cysteinyl leukotriene receptor 1: Brain entry receptor: ALOX5 (5-lipoxygenase) and PLA2G4A (cytosolic phospholipase a2) also play a role in brain entry Zhu et al, 2016
  32. DYRK3 dual specificity tyrosine phosphorylation regulated kinase 3: involved in infection of brain microvascular endothelial cells Huang et al, 2011
  33. EZR ezrin: C. neoformans activates RhoGTPases and subsequently FAK, ezrin, and PRKCA to promote traversal across human brain microvascular endothelial cells monolayer Kim et al, 2012.
  34. FAS Fas cell surface death receptor: capsular polysaccharides, galactoxylomannan and glucuronoxylomannan from C.Neoformans induce macrophage apoptosis via FAS/FASLG Villena et al, 2008
  35. FASLG Fas ligand:"" Villena et al, 2008
  36. FN1 fibronectin: cleaved by a fungal protease Rodrigues et al, 2003
  37. FPR2 formyl peptide receptor 2:Lung expression induced by infection in mice Colby et al, 2016
  38. FYN FYN proto-oncogene, Src family tyrosine kinase :Src family kinases, Fyn and Lyn, redundantly mediate anticryptococcal activity through the activation of PI3K and ERK1/2, which in turn facilitates killing by inducing the polarization of perforin-containing granules to the NK cell-cryptococcal synapse.Oykhman et al, 2013
  39. GABARAPL2 GABA type A receptor associated protein like 2 (atg8): RNA silencing reduces infection in mice Hu et al, 2008
  40. GNLY Granulysin: Possesses antifungal activity Ma et al, 2002
  41. GPR34 impaired immune response in GPR34-deficient mice infected with Cryptococcus neoformans Preissler et al, 2015
  42. ICAM1 C. neoformans infection led to enhanced expression of adhesion molecules macrophage 1 antigen (ITGAM) on neutrophils and ICAM1 on brain endothelial cells Zhang et al, 2016
  43. IFNAR1 interferon alpha and beta receptor subunit 1: defects of IFNAR1 led to improved clearance of infection with C. neoformans and enhanced synthesis of IFNG and the IL4-dependent production of mucin Sato et al, 2015
  44. IFNG interferon, gamma: promotes phagocytosis of Cryptococcus neoformans by murine macrophages Ikeda-Dantsuji et al, 2015.
  45. IL1B interleukin 1 beta: secretion activated by infection Chen et al, 2015
  46. IL2 interleukin 2 : IL2 and CSF2 are capable of stimulating human peripheral blood mononuclear cells-mediated antifungal activity Collins and Bancroft, 1992
  47. IL8: Fungal glucuronoxylomannan binds to CD14 in human A549 alveolar cells inducing interleukin-8 production Barbosa et al, 2014
  48. IL13 induces disease-promoting type 2 cytokines, alternatively activated macrophages and allergic inflammation during pulmonary infection of mice with Cryptococcus neoformans Müller et al, 2007 .
  49. IL17A interleukin 17A: enhances host defense against cryptococcal lung infection via leukocyte recruitment, activation, and IFNG production Murdock et al, 2014.
  50. ITGAM integrin subunit alpha M: Macrophages bind and phagocytose opsonized C. neoformans via three major complement receptors CR1, ITGB2/ITGAM , and ITGB2/ITGAX Levitz, 2002
  51. ITGAX integrin subunit alpha X :Macrophages bind and phagocytose opsonized C. neoformans via three major complement receptors CR1, ITGB2/ITGAM , and ITGB2/ITGAX Levitz, 2002
  52. ITGB2 integrin subunit beta 2: Macrophages bind and phagocytose opsonized C. neoformans via three major complement receptors CR1, ITGB2/ITGAM , and ITGB2/ITGAX Levitz, 2002
  53. LYN proto-oncogene, Src family tyrosine kinase: Fyn and Lyn, redundantly mediate anticryptococcal activity through the activation of PI3K and ERK1/2, which in turn facilitates killing by inducing the polarization of perforin-containing granules to the NK cell-cryptococcal synapse.Oykhman et al, 2013
  54. MAP1LC3A microtubule associated protein 1 light chain 3 alpha: Atg2a, Atg5, Atg9a, Atg12 and MAP1LC3A (LC3) RNA silencing in murine RAW264.7 macrophages decreases C.Neoformans uptake or replication Qin et al, 2011
  55. MBL2 mannose binding lectin 2 : Addition of MBL2 to MBL2 deficient serum increased the deposition of C4 and C3b and enhanced the uptake of C. albicans, C. parapsilosis and acapsular C. neoformans by polymorphonuclear cells van Asbeck et al, 2008
  56. MMP3 matrix metallopeptidase 3: significant increases of MMP3 and MMP12 mRNA levels and MMP12 zymographic activities in response to C. neoformans but not C. gattii infection in mice Supasorn et al, 2016
  57. MMP12 matrix metallopeptidase 12: significant increases of MMP3 and MMP12 mRNA levels and MMP12 zymographic activities in response to C. neoformans but not C. gattii infection in mice Supasorn et al, 2016
  58. MRC1 mannose receptor, C type 1: Cryptococcus neoformans glycoantigens are captured by multiple lectin receptors including MRC1 (CD206) and CD209 and presented by dendritic cells Mansour et al 2006
  59. MSR1 macrophage scavenger receptor 1: modulates the immune response to pulmonary Cryptococcus neoformans infection Qiu et al, 2013.
  60. NLRP3 NLR family, pyrin domain containing 3: Cryptococcus neoformans activates the NLRP3 inflammasome Guo et al, 2014.
  61. NOS2 nitric oxide synthase 2 : upregulated in granulomas composed of T cells (CD4+ and CD8+) and macrophages (CD11b/c+) by infection in rats Goldman et al, 1996
  62. PLAU plasminogen activator, urokinase: Induction of brain microvascular endothelial cell urokinase expression by C.Neoformans facilitates blood-brain barrier invasion Stie and Fox, 2012.
  63. PLG plasminogen:interacts with surface molecules on Cryptococcus neoformans Ikeda and Ichikawa, 2014
  64. PRDX1 peroxiredoxin I: PRDX1 and S100A10 regulated during invasion of human umbilical vein endothelial cells by C. neoformans Wang et al, 2011
  65. PRF1 perforin: NK cells use perforin for anticryptococcal activity Wiseman et al, 2007.
  66. PRKCA protein kinase C alpha: C. neoformans activates RhoGTPases and subsequently FAK, ezrin, and PRKCA to promote traversal across human brain microvascular endothelial cells monolayer Kim et al, 2012.
  67. PTK2 protein tyrosine kinase 2 (FAK): C. neoformans activates RhoGTPases and subsequently FAK, ezrin, and PRKCA to promote traversal across human brain microvascular endothelial cells monolayer Kim et al, 2012.
  68. PTX3 pentraxin 3:upregulated in the brain of mice infected with Candida albicans or Cryptococcus neoformans Polentarutti et al, 2000.
  69. RAB5A, member RAS oncogene family: Live cryptococci, but not heat-killed pathogens or inert targets, induce the premature removal of the early phagosome markers Rab5 and Rab11 Smith et al, 2015
  70. RAB11 Live cryptococci, but not heat-killed pathogens or inert targets, induce the premature removal of the early phagosome markers Rab5 and Rab11 Smith et al, 2015
  71. RAC1 C.neoformans phospholipase B1 activates host cell Rac1 to cross the blood-brain barrier Maruvada et al, 2012.
  72. RHOA ras homolog family member A: Cryptococcus activates RhoA, Rac1, and Cdc42, and this isrequired for cryptococcal transmigration across human brain microvascular endothelial cells Kim et al, 2012
  73. S1PR2 sphingosine-1-phosphate receptor 2: extracellular S1P enhances the phagocytosis of C. neoformans by alveolar macrophages via S1PR2 McQuiston et al, 2012
  74. S100A8/S100A9 = calprotectin : Cytoplasmic antifungal peptide Mambula et al, 2000
  75. S100A10: S100 calcium binding protein A10: downregulation inhibits the phagocytosis of Cryptococcus neoformans by murine brain microvascular endothelial cells Chen et al, 2011
  76. SCARF1 scavenger receptor class F member 1: SCARF1 and CD36, mediate host defense against Cryptococcus neoformans and Candida albicans Means et al, 2009
  77. SFTPD surfactant protein D: facilitates Cryptococcus neoformans infection Geunes-Boyer et al, 2012.
  78. STAT1 required for macrophage kiling of the pathogen Wager et al, 2015
  79. TF transferrin has antifungal activity Shiraishi and Arai, 1979
  80. TLR1 agonists of TLR1/2, TLR3, TLR4 and TLR9 receptors stimulate C.Neoformans phagocytosis by microglia Redlich et al, 2013..
  81. TLR2 agonists of TLR1/2, TLR3, TLR4 and TLR9 receptors stimulate C.Neoformans phagocytosis by microglia Redlich et al, 2013
  82. TLR3 agonists of TLR1/2, TLR3, TLR4 and TLR9 receptors stimulate C.Neoformans phagocytosis by microglia Redlich et al, 2013.
  83. TLR4 agonists of TLR1/2, TLR3, TLR4 and TLR9 receptors stimulate C.Neoformans phagocytosis by microglia Redlich et al, 2013..
  84. TLR9 modultes antifungal activity Kasperkovitz et al, 2011
  85. TYROBP TYRO protein tyrosine kinase binding protein (DAP12): inhibits pulmonary immune responses to Cryptococcus neoformans Heung and Hohl, 2016 .

Bulk experiments

Cryptococcus neoformans promotes its transmigration into the central nervous system by inducing molecular and cellular changes in brain endothelial cells Vu et al, 2013.

Modulated proteins : ANXA2 CALU FGA FGB GOT2 HBA1 HBB HIST1H2BK HIST1H3F HIST2H4B HLA-A IMMT KPNB1 LDHA PDIA3 PGAM1 PGK1 PPIA RCN1 RPN1 RPN2 S100A10 TAGLN2 VDAC1 VDAC2 (and translocation of HMGB1)

Cryptococcus inositol utilization modulates the host protective immune response during brain infection Liu et al, 2014.

Significant differentially expressed genes involved in neurological disorder and cell death networks in the wild type or the itr1a itr3c mutant infected mouse brain

ABCA2 ABCA5 ABCB1 ABHD12 ACHE ACOT11 ACTB ACTN2 ACVR1B ADAM22 ADCK3 ADORA1 AEBP1 AFF1 AGTPBP1 AGXT2L1 AHCY AK1 ALX4 ANKRD11 ANO3 APBA2 APLP1 APOD APOE AQP4 ARAF ARFGEF2 ARHGEF1 ARHGEF9 ARMCX3 ARNTL ARPP19 ARPP21 ASCL1 ATF2 ATP13A2 ATP1A3 ATP1B2 ATP2A2 ATP2B1 ATP2B2 ATP2C1 ATP5C1 ATP5L ATP5O ATP6V1B2 ATP6V1E1 ATXN1 ATXN10 ATXN3 B2M BAG1 BAIAP2 BCAS1 BCL2 BCL2L1 BCL6 BDNF BHLHE40 BMPR1A BRSK1 C10orf2 C4A C4B CA12 CA2 CA8 CACNA1A CACNA1G CACNA2D1 CACNB4 CACNG2 CALR CAMK2A CAMK2B CAMK4 CAMTA1 CAPNS1 CAPZB CASP12 CBLN1 CCDC88C CD74 CDH2 CDKN1A CDON CDS1 CECR2 CEP63 CFLAR CHGA CHRM1 CHRNA2 CHRNB2 CIRBP CIT CKB CLCN3 CLU CNP CNR1 CNTFR CNTN1 COL18A1 COMT COPE COX5B COX7B CPLX1 CPLX2 CPNE5 CREB1 CREB3L1 CREBBP CRYM CTIF CTSA CTSB CTSD CTSS CX3CL1 CYC1 CYP51A1 DBP DGKB DICER1 DIRAS2 DLG2 DLG4 DNM1L Dst DTNA DYRK1A E2F5 EEF1A2 EFNB3 EGLN2 EGR1 EGR2 EGR3 EGR4 EIF3E EIF3K ELAVL2 ELOVL1 EML1 ENO2 EP300 EPHA7 ERRFI1 ETS2 ETV1 F3 FABP7 FAIM2 FAM107A FAS FBXW7 FCGR1A FDFT1 FGF12 FGFR3 FKBP1A FKBP8 FKRP FKTN FLNA FLRT2 FMOD FMR1 FOS FOSB FOXG1 FOXN3 FOXO1 FOXP1 FRAT1 FTH1 GAA GABBR1 GABRA1 GABRA2 GABRA4 GABRB2 GABRB3 GABRD GAD2 GAN GAPDH GDA GFAP GIGYF2 GJB6 GLRX GNAL GNAO1 GNAQ Gnas GNG3 GNG7 GPD1 GPI GPR56 GRIA2 GRIA3 GRID2 GRIK2 GRIN1 GRM1 GRM3 GRM5 GSK3A GSK3B GZMB H3F3A H3F3B HAP1 HCN2 HERPUD1 HEXB HINT1 HIP1 HIPK1 HK2 HLA-B HMGB1 HMGCR HMGCS2 HMOX1 HNRNPU HOMER1 HRH1 HSP90AA1 HSPA8 HSPG2 ICAM5 ID3 IDS IER5 IFT57 IGBP1 IGF1 IGF2 IGF2R IGFBP5 IL1R1 IL1RN ITPR1 IVNS1ABP JUNB KCNA1 KCNAB2 KCNC2 KCND2 KCNJ10 KCNK3 KCNN3 KCTD13 KDM6A KIF1B KLF6 LAMA2 LAMA4 LAMP1 LAPTM4B LCN2 LDHA LDHB LMO4 LPAR1 LRG1 LRP1 LRP6 LRP8 LRPAP1 LRRK2 MAG MAL2 MAN1A1 MAP1B MAP2K1 MAPK8 MAPK8IP1 MAPK8IP2 MBNL2 MBP MDH1 MDM4 MEF2C MEN1 MERTK MFN2 MLF2 MOG MPDZ MT1E MT1H MT3 MYCN MYO5A MYT1L NAB1 NAP1L5 NAPA NAPB NBEA NCF1 NCS1 NDE1 NDRG1 NDRG2 NDST3 NDUFS2 NEFL NEUROD1 NF1 NFIA NFIB NFKBIA NGFR NIN NOTCH2 NPAS3 NPAS4 NPTX1 NR1D1 NR4A1 NR4A2 NRCAM NREP NRGN NRXN1 NTSR2 OPRL1 ORC4 OSBPL8 OXR1 P4HB PAFAH1B1 PCDH7 PDE10A PDE1B PDS5B PEA15 PEBP1 PEG3 PFKM PGK1 PINK1 PITPNM1 PKM PLCB1 PLCB4 PLK2 PLP1 POR PPIA PPP1CB PPP1R1B PPP1R9B PPP3CA PRDX2 PRDX6 PRG4 PRKACA PRKCB PRNP PRRT2 PSAP PSAT1 PSMB6 PSMB8 PTEN PTK2B PTPN5 PTPN9 PVALB RAB3A RAB5A RALA RAP1GAP RAPGEF2 RASD2 RBFOX1 RBPJ RHOBTB3,RHOG RIN2 RNF10 RNF170 ROCK2 RORA RPL13A RPL15 RPL17 RPL3 RPL31 RPS3 RPS4X RPS6KA3 RPSA RREB1 RTN1 RTN4 RYR1 RYR3 S1PR1 SCAMP5 SCD2 SCN1A SCN2A SCN2B SCN4B SCN8A SCOC SDC4 SDHB SEPP1 SERPINA3 SERPINE1 SERPINI1 SETX SGK1 SH3PXD2A SHC3 SLC17A7 SLC18A2 SLC1A2 SLC1A3 SLC2A1 SLC32A1 SLC6A3 SLC6A4 SLIT2 SLMAP SMPD1 SMTN SNAP25 SNCA SNCB SNX2 SORL1 SOX2 SOX9 SP3 SPOCK3 SPTBN2 SRGAP3 STARD10 STAT1 STMN1 SUCLA2 SUMO3 SV2A SYN1 SYNE1 TAF4 TARDBP TESC TF TFAM TFAP2B TGFA TGM1 TGM2 THY1 TLR4 TMEFF1 TMSB4X TNFRSF1A TNFSF10 TOP1 TPI1 TRAK2 TRPM7 TSC22D3 TTBK2 TTL TUBA1A TUBB4A TUBB4B TWSG1 UBE3A UCHL1 UCP2 UGCG UGT8 ULK2 UNC13C UQCRC1 USP2 USP36 VAMP1 VAMP2 VLDLR VPS13A VPS33A VSNL1 WNK1 XIAP YWHAB YWHAE ZBTB16 ZBTB44 ZFP932 ZIC1 ZIC5 ZNF592

Significant differentially expressed genes involved in cell viability and survival, proinflammatory response and cell mediated immunity networks in the wild type or the itr1a itr3c mutant infected mouse brain

ACER2 ACTB ADAMTS1 ADIPOR2 AFF1 AGO2 AGT AHNAK ALCAM ANLN ANXA3 ANXA7 APC APLN APOE ARG1 ATF3 B2M BCL3 BCL6 BDNF BIRC6 BNIP3 BTG2 C1QA C3 C3AR1 C4A/C4B CA2 CALM1 CAPG CAV1 CCL13 CCL2 CCL24 Ccl6 CCL7 CCNG1 CCR1 CCR5 CD14 CD274 CD300LF CD44 CD74 CD86 CDK2AP1 CDKN1A CEBPD CFB CFH CIITA CLEC6A CLEC7A CLU CNN3 COL4A1 CSF1 CSF2RB CTSB CTSS CX3CL1 CXCL10 Cxcl12 CXCL16 CXCL9 CYBA CYBB DAB2 DDX58 DGKB DUSP1 DUSP6 EDNRB EGR1 EGR2 EGR3 EIF2AK2 EIF3E ENTPD1 ETV6 EZR F10 FADS2 FAS FAT1 FCER1G FCGR1A FCGR2A FCGR2B FCGR3A FGFR2 FKBP5 FLT4 FN1 FOS FTH1 FYB GFAP GUCY1A3 GZMB HBB Hbb-b2 HCK HIVEP2 HLA-B HLA-DQA1 HLA-DQB1 HLA-DRA HLA-E HLF HMGCR HMOX1 HPSE HRH3 ICAM1 ICOSLG IFI27 IFI30 IFIH1 IFNG IGFBP5 IGFBP7 Igtp IKZF1 IL10RA IL12RB1 IL16 IL17RB IL18BP IL1RN IL2RB IL4R IRF1 IRF2 IRF8 IRF9 IRGM ITGAM ITGAX ITGB1 ITGB2 JAK2 JAK3 JUNB JUND KCNA1 KDR KIF1B KLF5 LANCL2 LAPTM4B LCN2 LCP1 LCP2 LGALS3 LGALS9 LGMN LINGO1 LRRK2 LYN LYZ1 LYZ2 MAN2A1 MAP2K1 MAPK8IP1 MBD2 MBP MCAM MCL1 MERTK MFGE8 MICAL2 MIF MKI67 MMP14 MSN MSR1 MT1E MT1H Mx1/Mx2 MYC MYD88 MYH10 MYH11 NAMPT NCF4 NCKAP1L NFKBIA NOD1 NOTCH2 NOV NPY NR3C1 NR4A1 NR4A2 NR4A3 NRN1 OSMR P2RY12 P4HB PARP14 PCSK1 PDIA3 PDK4 PENK PGLYRP1 PIK3IP1 PLAC8 PLAUR PML PNP POMC PPAT PPP3R1 PRDX6 PRKCB PSAP PTN PTPN5 PTPRC PTPRN RAC2 Retnla RHOJ RIPK1 RPS6 RSAD2 RUNX1 RXRG S100A11 S1PR1 SCD SELL SELP SERPINI1 SGK1 SHC3 SLC16A1 SLC1A2 SLC1A3 SLC22A8 SLC2A1 SLC31A1 SOCS1 SOCS3 SOX10 SPARC SPI1 SPP1 SST STAT1 STAT2 STAT3 TAPBP TGM1 TGM2 THBD THEMIS2 TIMP1 TLR4 TNFRSF1A TNFRSF9 TNFSF10 TOP2A TRAF3 TRIM21 TUBA4A TUBB3 TUBB4A TUBB6 TXNIP UNC5B VAV1 VCAM1 VGF VIM VTN VWF XDH ZBTB16 ZEB1 ZFP36 ZNF207

Significant differentially expressed genes involved in interferon gamma and tumor necrosis factor alpha networks in the wild type or the itr1a itr3c mutant infected mouse brain

ABCA2 ABCB1B ABCC1 ABCC3 ABCD2 ABCG2 ABLIM3 ABR ABTB2 ACADM ACE ACER2 ACOX1 ACSL1 ACTB ADAM8 ADAM9 ADAMTS1 ADAMTS5 ADCY8 ADCY9 ADD1 ADIPOQ ADIPOR2 ADM ADORA2A ADRA1A ADRA2C ADRB3 AEBP1 AFF1 AGER AGO2 AGT AGTR1 AGXT2L1 AHNAK AIF1 AK2 ALAD ALAS2 ALCAM ALDH1A2 Aldh1a7 ALDH2 ALDH3A1 ALDOC ALOX12B ALOX5 ALPL ANGPT1 ANGPT2 ANGPTL4 ANKRD13A ANLN ANXA11 ANXA3 ANXA7 AOC3 APC APLN APLP2 APOBEC1 APOBEC3B APOC2 APOD APOE APPL2 AQP1 AQP7 ARC ARF4 ARFGEF2 ARG1 ARHGAP5 ARHGDIB ARL4A ARPC1B ARPP19 ARRDC2 ARRDC3 ARSB ASAP1 ASGR1 ASPG ASS1 ATF3 ATP1A1 ATP1A2 ATP1A3 ATP2A2 ATP2B2 ATP5B ATXN3 AVPR1A B2M B4GALT1 BAALC BACH2 BAX BAZ1A BBS1 BCKDHA BCKDHB BCL2A1 BCL2L13 BCL3 BCL6 BDNF BGN BHLHE40 BID BIRC2 BIRC3 BIRC6 BMP2K BMP4 BMPR1A BNIP3 BST2 BTG1 BTG2 BUB1B C10orf10 C11orf82 C1QA C1QB C1QC C1R C1S C2 C21orf33 C3 C3AR1 C4A C4B CA2 CABLES1 CADM3 CALM1 CAMK2A CAMKK1 CAP2 CAPG CASP1 CASP12 CASP4 CASP6 CASP7 CAT CAV1 CCK CCL1 CCL13 CCL2 CCL20 CCL24 CCL27 CCL3L1/CCL3L3 CCL4 CCL5 CCL6 CCL7 CCL8 CCL9 CCNG1 CCR1 CCR2 CCR4 CCR5 CCR8 CD14 CD180 CD247 CD274 CD28 CD300LF CD3E CD4 CD40 CD40LG CD44 CD5 CD53 CD68 CD69 CD74 CD80 CD82 CD83 CD86 CDC25C CDC42EP1 CDH13 CDH2 CDK2AP1 CDK5R2 CDKN1A CDKN2C CDO1 CEBPD CELF1 CFB CFD CFH CFLAR CFP CH25H CHD5 CHGA CHPF CHST2 CHST4 CIB2 CIDEC CIITA CLDN11 CLEC2D CLEC4E CLEC5A CLEC6A CLEC7A CLIC1 CLIC4 Clu CMPK2 CNN3 CNTN4 COL1A2 COL4A1 COL5A3 CORO2B COTL1 CP CPLX2 CPT1A CPT2 CRADD CREM CROT CRYAB CRYM CSF1 CSF1R CSF2 CSF2RB CST7 Ctla2a/Ctla2b CTLA4 CTNNB1 CTSB CTSC CTSD CTSF CTSS CTSZ CX3CL1 CX3CR1 CXCL10 Cxcl12 CXCL13 CXCL16 CXCL2 CXCL6 CXCL9 CXCR2 CXCR3 CYBA CYBB CYLD CYP1A1 CYP1B1 CYP2E1 CYP7B1 CYTH3 CYTIP DAB2 DACT3 DAG1 DAXX DBI DBP DBT DCLK1 DCN DDIT4 DDX58 DGKB DGKZ DHRS3 DHX58 DIRAS2 DKK3 DLG4 DLGAP3 DNAH8 DNAJB11 DNMT1 DPP4 DUSP1 DUSP14 DUSP2 DUSP5 DUSP6 EBI3 ECH1 EDN1 EDN3 EDNRB Eef1a1 EEF1G EFNA1 EFNB2 EFNB3 EGFR EGR1 EGR2 EGR3 EGR4 EID1 EIF2AK2 EIF3E EIF4A2 EIF4B EIF4G3 ELAVL3 ELMO2 EML1 EMP1 EMP2 ENPP3 ENTPD1 ENTPD5 EPB41L1 EPB49 ERAP1 ERCC1 ERG ERRFI1 ESM1 ESRRA ETV6 EZR F10 F2RL1 F3 FABP1 FABP4 FABP7 FADS2 FAM107A FARP1 FAS FASLG FAT1 FAT2 FBL FBXO32 FCER1G FCER2 FCGR1A FCGR2A FCGR2B FCGR3A FCGRT FERMT3 FGF10 FGF2 FGFR2 FGFRL1 FGL2 FKBP5 FLNC FLT4 FMO1 FMOD FN1 FNBP1 FOS FOSB FOXO4 FPR1 FSCN1 FSTL1 FSTL4 FTH1 FTL FUT4 FYB GAB1 GAS5 GAS7 GATM GBP2 GBP5 Gbp6 (includes others) GCLM GFAP Ggta1 GHR GIT1 GJB1 GJB6 GLG1 GLIPR2 GLUL Gm12250 GNA13 GNAI1 GNAO1 GNB4 GNL1 GOSR2 GPD1 GPNMB GPR126 GPR176 GPR182 GPR37 GPRC5B GRIA1 GRM4 GRN Gsta4 GSTM2 GSTT1 GUCY1A3 GUSB GZMB H19 HAL HAPLN1 HBA1 HBA2 HBB Hbb-b2 HCAR2 HCK HCLS1 HCN2 HEBP1 HELZ2 HERC1 HES1 HEXB HEYL HIF1A HIF3A HIPK3 HIVEP1 HIVEP2 HK2 HK3 HLA-B HLA-C HLA-DMB HLA-DQA1 HLA-DQB1 HLA-DRA HLA-E HLA-F HLF HMGB1 HMGCR HMGCS1 HMGN2 HMOX1 HNRNPF HNRPDL HOMER1 HPGD HPGDS HPRT1 HPSE HRH3 HSD11B1 HSPA2 HTRA1 HUWE1 ICAM1 ICOSLG ID1 IDH2 IDO1 IER2 IFI202B IFI204 Ifi204 (includes others) IFI27 IFI27L2 IFI30 IFI35 IFI44 IFI44L Ifi47 IFIH1 IFIT1B IFIT2 IFIT3 IFITM1 Ifitm2 IFNAR2 IFNG IFNGR2 IGFBP5 IGFBP6 IGFBP7 Igtp Iigp1 IKBKE IKZF1 IL10 IL10RA IL12B IL12RB1 IL13RA1 IL15RA IL16 IL17RB IL17RD IL18 IL18BP IL1B IL1R1 IL1RN IL21 IL21R IL2RA IL2RB IL4R IL6 INHBA Ins1 IRF1 IRF2 IRF5 IRF7 IRF8 IRF9 IRGM ISG15 ISG20 ITGA4 ITGAL ITGAM ITGAX ITGB1 ITGB2 ITGB4 ITGB6 ITGB7 ITM2A ITPR1 JAK2 JAK3 JUNB JUND KALRN KAT6B KCNA1 KCNJ1 KCNJ10 KCNK3 KDR KIAA1549L KIF1B KIF20A KIT KITLG KLF10 KLF15 KLF5 KLF9 KRT23 KYNU LAIR1 LAMP3 LANCL2 LAP3 LAPTM4B LAPTM5 LCAT LCN2 LCP1 LCP2 LDB2 LEP LGALS12 LGALS3 LGALS3BP LGALS9 LGMN LIF LIFR LILRB4 LINGO1 LITAF LOX LPL LRRC8C LRRK2 LTB LTBP4 LUZP2 LXN LY6A LY6E LY86 LY9 LYN LYVE1 Lyz1/Lyz2 Macf1 MAFB MAFK MAL MALAT1 MAN1C1 MAN2A1 MAP1A MAP1B MAP2K1 MAP2K3 MAP3K14 MAP4 MAP4K4 MAP7 MAPK8IP1 MAPKAP1 MARCKSL1 MBD2 MBP MCAM MCL1 MCM3 MEFV MEOX1 MEOX2 MERTK METRN MEX3B MFGE8 MFSD2A MGP MICAL2 MID1IP1 MIDN MIF MILR1 MKI67 MKX MLKL MMP13 MMP14 MMP15 MMP16 MMP28 MMP7 MMP8 MMP9 MPC1 MPEG1 MRC1 MS4A6A Ms4a6c MSN MSR1 MT1E MT1H MUC4 MVP Mx1/Mx2 MXD1 MYC MYD88 MYH10 MYH11 MYH14 MYO9B NAAA NAGLU NAIP NAMPT NAV1 NCAM1 NCAN NCF1 NCF2 NCF4 NCKAP1L NCL NCOA2 NEDD9 NEUROD6 NEXN NFATC2 NFKB1 NFKB2 NFKBIA NFKBIE NFKBIZ NFRKB NIPAL4 NLRC5 NLRP3 NME3 NNAT NNMT NOD1 NOD2 NOS2 NOTCH2 NOV NPAS4 NPC2 NPM1 NPM3 NPPA Nppb NPPC NPY NQO1 NR1D1 NR3C1 NR3C2 NR4A1 NR4A2 NR4A3 NREP NRN1 NRP1 NRXN2 NTN1 NUAK1 NUAK2 OAS1 OAS2 OAS3 OASL OCLN OGN OLFML2B OLR1 OSGIN1 OSMR P2RY12 P2RY6 P4HB PABPC1 PACSIN1 PAFAH2 PAQR7 PARD3 PARP10 PARP12 PARP14 PARP9 PC PCBP2 PCDH15 PCDH7 PCK1 PCK2 PCP4 PCSK1 PCSK6 PDCD1 PDE10A PDE2A PDE8B PDGFA PDGFRA PDIA3 PDK4 PDPN PDZD2 PECAM1 PEG10 PENK PER3 PGLYRP1 PHF15 PIGR PIK3AP1 PIK3IP1 PKMYT1 PLA1A PLA2G16 PLA2G3 PLA2G4A PLA2G5 PLA2G7 PLAC8 PLAU PLAUR PLCE1 PLCL1 PLEK PLIN1 PLIN4 PLK3 PLLP PLSCR1 PLTP PLXNA3 PML PNP PNPLA2 PODXL POLA2 POMC POMT1 PPAP2A PPAP2B PPARA PPARD PPARG PPARGC1A PPAT PPM1K PPP1R12C PPP1R3C PPP3R1 PRDX6 PREX1 PRKCB PRKCD PRLR PROS1 PRRC2A PRRC2B PRSS23 PSAP PSAT1 PSD2 PSD3 PSMA2 PSMB10 PSMB8 PSMB9 PSME1 PSME2 PTEN PTGDS PTGS2 PTN PTPLB PTPN5 PTPRC PTPRN PTX3 PXDN PXMP2 PYCARD R3HDM1 RAB32 RAB3C RAB6B RAC2 RALGDS RANBP3 RANBP9 RAPGEF2 RARRES2 RASD1 RASL10B RBFOX1 RBM3 RBMX2 RCAN1 RCAN2 RCN3 REL RELB RETN RETLNA RFTN1 RFX5 RGS1 RGS10 RGS14 RGS16 RGS2 RGS20 RGS4 RGS5 RGS7 RHOB RHOJ RHOU RIPK1 RIPK2 RNASE2 RNASE4 RND3 RNF149 ROBO1 RPH3A RPL3 RPS12 RPS19 RPS24 RPS4X RPS6 RPS6KB1 RRBP1 RRM2 RSAD2 RTP4 RUNX1 RUNX2 RXRG S100A11 S100A8 S1PR1 SAMD4A SAMD9L SAMHD1 SASH1 SBNO2 SCAMP1 SCD SCD2 SCG2 SCN4B SCNN1A SCNN1B SCNN1G SCUBE1 SDC2 SDC4 SELE SELL SELP SELPLG SEMA3C SEMA6D SEPP1 SERINC3 SERPINA3 SERPINA3G SERPINB9 SERPINE2 SERPINF1 SERPINF2 SERPING1 SERPINI1 SGK1 SHANK1 Shank3 SHC3 SHH SIGLEC1 SLC12A5 SLC14A1 SLC15A3 SLC16A1 SLC1A2 SLC1A3 SLC1A4 SLC20A1 SLC22A8 SLC2A1 SLC31A1 SLC33A1 SLC4A1 SLC5A11 SLC5A8 SLC6A11 SLC6A15 SLC6A6 SLC7A5 SLC7A8 Slco1a4 Slfn1 SLFN12L Slfn2 SLIT2 SLITRK2 SMAD3 SMO SMOX SMPD1 SMPD2 SMPDL3A SMURF1 SMURF2 SNCG SND1 SOCS1 SOCS3 SOD1 SORBS1 SORL1 SOX10 SOX8 SP1 SP110 SP3 SPAG9 SPARC SPARCL1 SPHK1 SPI1 SPP1 SPRY2 SPTBN2 SQSTM1 SRGN SRSF10 SSR2 SSR3 SST ST3GAL5 ST3GAL6 ST6GAL1 STARD3 STAT1 STAT2 STAT3 STAT4 STEAP4 STMN1 SULT2A1 SV2B SYN1 SYNJ2 SYTL1 TAGLN2 TAP1 TAP2 TAPBP TBC1D30 TBR1 TBX21 TBXAS1 TDRD7 TEK TF TFEC TFPI TGFBI TGM1 TGM2 TGTP1 THBD THBS4 THEMIS2 THY1 TIMELESS TIMP1 TIMP2 TIMP4 TJP1 TLR2 TLR4 TLR7 TLR8 TM4SF1 TMEM173 TMSB4X TNF TNFAIP2 TNFAIP3 TNFAIP8 TNFRSF11A TNFRSF18 TNFRSF1A TNFRSF1B TNFRSF4 TNFRSF9 TNFSF10 TNFSF13B TNFSF15 TNIP1 TNN TOP2A TPD52L2 TPT1 TRADD TRAF1 TRAF2 TRAF3 TRAF6 TRAFD1 TREM2 TREML2 TRIM21 TRIM25 TRIM30A TSC22D3 TTBK1 TUBA4A TUBB3 TUBB4A TUBB6 TULP4 TWIST2 TXNIP TYK2 TYRO3 UBA7 UBD UBE2L6 UCP1 UCP2 UGT8 UNC13A UNC5B USP18 USP2 VASP VAV1 VCAM1 VGF VIM VIPR2 VTN VWA5A VWF WHSC1 WIPF3 WISP1 WLS WNK1 WNK2 WNT5A WNT7A WTAP WWC1 XAF1 XDH ZBP1 ZBTB16 ZC3H12A ZC3HAV1 ZEB1 ZFP36 ZIC1 ZNF207 ZNF217 ZNF365 ZNF804A

Macrophage mitochondrial and stress response to ingestion of Cryptococcus neoformans.Coelho et al, 2015

Upregulated at 2hr

1810011O10RIK 9230105E10RIK A630033H20RIK BHLHE40 CCL2 CCL7 CTLA2B E330009J07RIK EGR2 EMP1 FOSL1 GAS5 GLIPR1 GPRC5A HMGB1 ID2 ITGA5 JUNB LIMA1 MAFF MIR186 MIR297B MUP2 OLFR804 PDGFB PHLDA1 PLK3 RGS1 RHOB SERPINE1 SH3PXD2A SNORA41 SNORA69 TMEM65
Downregulated at 2hr CLEC2D

Upregulated at 24hr: ACSBG1 ANKRD37 ANXA2 APOLD1 APPL2 ARRB1 ARRDC3 ARSB BHLHE40 BNIP3 CCNG2 CD5 CHST11 CISH DDIT4 ECHDC3 EGLN1 EMP1 ENO2 ERO1L F10 FABP4 FBXO36 FLRT2 GATSL3 GBE1 GLIPR2 GLRX GM2A GM5617 GRHPR HIGD1A HMOX1 HYAL1 ID2 IER3 IGF2BP2 IL13RA1 IL1R2 LRP2BP MTSS1 MXI1 NAGLU NAT6 NDRG1 NIACR1 NOS2 OLFR50 P4HA1 P4HA2 P4HB PGM2 PITPNC1 PLAU PLOD2 PPP1R3B PRELID2 PTGES RIPK2 SDC3 SELENBP1 SELENBP2 SERPINE1 SLC2A1 SLC2A3 SLC39A10 TGFB3 TIPARP TMSB10 TNFRSF9 ZC3H6

Downregulated 24hrs: APEX1 BRCA1 CHAF1B DHX9 EXO1 HELLS I FT74 MAT2A MBOAT1 PGD SAMD9L SFPQ SHMT1 SLC7A11 SNHG1 SNHG1 SNORD52 SRRT SRSF1 UHRF1 WDHD1 WDR76

Upregulated at 24hrs vs 2hrs post-infection: ABTB1 ACSBG1 ACYP1 AI413582 AKT3 ALDH1L2 ALDOC AMDHD2 AMHR2 AMN1 AMZ2 ANGPTL6 ANKRD37 ANKRD55 AP3M2 APPL2 AQP9 ARHGEF12 ARHGEF3 ARL2 ARL5C ARRB1 ARRDC3 B4GALT3 BC016495 BCAP31 BNIP3 BNIP3 BOLA1 BPHL BTBD2 CARF CBR4 CCDC111 CCDC130 CCDC28B CCNG2 CCR5 CD37 CD47 CD5 CD74 CDA CDK2AP2 CDK5RAP3 CDKN1B CEACAM16 CETN4 CHAC1 CHCHD5 CIR1 CISH CLEC2D CLK3 COASY COQ9 CRYZ CSPRS CXCL2 CYP4F13 DDIT3 DDIT4 DDX58 DEFB25 DGKG DGUOK DLG4 DPEP2 DTWD1 DUS2L DUSP10 DYX1C1 EBI3 ECHDC3 EGLN1 EIF4EBP1 ELAC1 ENO2 ENTPD1 ERO1L ETV4 EXPI EZH1 FAM114A1 FAM162A FAM195B FAM71F2 FBXL20 FBXO36 FGF11 FKBP7 FLT3L GADD45A GATSL3 GBE1 GDPD3 GLIPR2 GLRX GM11428 GM2A GM5617 GM7609 GM7609 GM807 GM885 GM9856 GRCC10 GRHPR GSTM4 GTPBP2 GUCA1A GYS1 H1F0 H2-KE6 H2-OA H2-OB H2-Q6 H2-Q8 HBP1 HCST HEMK1 HERPUD1 HK2 HSPB11 HYAL1 HYI IER3 IGF2BP2 IGFBP6 IL13RA1 IL15 IL23A INSIG2 IQCG IRF2 ISG20 ISOC2B ITGA9 JHDM1D KAZALD1 KCTD13 KDM5B KHNYN KLK8 LIX1 LPIN1 LPP LRP2BP LRRC20 LRRC61 LSR LYSMD1 LYSMD1 MAPK1IP1 MARCH11 MFGE8 MPND MST1 MXI1 MXI1 NAGA NAGLU NAPB NAT6 NAT9 NDRG1 NENF NFU1 NIACR1 NOS2 NUDT16 NUDT8 NUPR1 OLFR368 OTUB2 P4HA1 P4HA2 P4HB PAFAH1B3 PARD6A PCTP PDE6D PFKP PGM2 PHF21A PHOSPHO2 PIM1 PIM2 PITPNC1 PLOD2 POLD4 POLK POLR3GL PPAPDC1B PPARD PPFIBP2 PPM1J PPP1R15A PPP1R3B PRDX5 PRELID2 PTGER2 PTGES PTGS2 PXMP4 PYCR1 RAB40C RABAC1 RAD9 RASSF4 RDH14 REEP6 RFESD RHBDD1 RINL RND1 RNF113A1 RNF157 RRAS RWDD3 SAMSN1 SCNM1 SDC3 SELENBP1 SELENBP2 SERTAD3 SESN2 SFT2D2 SIL1 SLC2A3 SLC30A9 SLC37A4 SLPI SOAT2 SPATA1 SPATA24 SPATA6 SQRDL SRA1 ST3GAL6 ST8SIA4 STAT2 SUV420H2 SYNGAP1 TAP1 TCP11L2 TGFB3 THAP3 THRA TICAM2 TMCO6 TMED4 TMEM140 TMEM206 TMEM218 TMSB10 TNFAIP8L2 TNFRSF9 TOR2A TRAPPC6A TRIB3 TRMT112 TRP53INP1 TSC22D3 TSPO TXNIP USE1 VDR VEGFA WDR54 YPEL3 YPEL5 ZC3H6 ZKSCAN14

Downregulated at 24hr vs 2hrs post infection: AKAP8 ANKRD32 AVEN BC005537 BC067068 BCLAF1 BLNK BOP1 C330027C09RIK C79407 CCDC86 CCDC99 CCL2 CCL7 CCNB1 CCNF CDC25A CDK12 CENPI CHEK1 CIRH1A CLSPN CORO1C CPEB2 CYP51 D230037D09RIK DDX3X DGCR8 DHX33 DHX9 DKC1 DNAJA1 DNAJC9 E2F3 EEF1E1 EID3 EIF3J EWSR1 EXO1 EXOSC9 FAM82A1 FASN FASTKD3 FOXR2 FUS GAS2L3 GAS5 GAS7 GCLC GM2022 GM5662 GMNN GNAT3 GPATCH4 GPS2 GRWD1 GSG2 HELLS HMGB1 HMGCR HPGDS IDI1 IDI1 ITGA5 KBTBD8 KTI12 LIMA1 LPHN2 LRPPRC MAP2K3 MAT2A MBOAT1 MCM2 MCM3 MCM4 MCM5 MFSD7B MIR17 MIR17HG MIR18 MIR1956 MIR24-1 MRC1 MS4A6C NASP NFKBID NFYC NFYC NKRF NMD3 NUF2 NUFIP2 NUP153 NUP43 PAXIP1 PCNA PCNA PDGFB PDLIM7 PDSS1 PGD PIK3R1 PMM2 POLE2 POP1 PPIL5 PPP2R1B PPRC1 PRIM1 PSPC1 PURB PUS7 REV1 RHOJ RIPK1 ROCK2 RPL23A RPS12 SERPINB8 SFPQ SHMT1 SLBP SLBP SLC23A2 SLC25A32 SLC30A1 SLC7A11 SMC2 SMEK1 SNHG1 SNHG1 SNHG1 SNHG1 SNHG8 SNORA20 SNORA21 SNORA21 SNORA23 SNORA26 SNORA28 SNORA3 SNORA3 SNORA31 SNORA41 SNORA61 SNORA69 SNORA73A SNORA73B SNORA74A SNORA7A SNORD14C SNORD14C SNORD14E SNORD16A SNORD22 SNORD52 SNORD58B SNORD68 SNORD87 SNORD95 SPTLC1 SRSF1 SRSF2 SRSF3 SRSF6 SRXN1 TACC3 TAF1D TAF1D TAF1D TAF1D TAF1D TAF1D TFRC THOC4 TLR7 TM4SF19

 

Infectious Diseases / Bacteria / Viruses news headlines provided courtesy of Medical News Today.

 

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Last update: January 4, 2017