If you know of other direct interactions,
(or corrections) please
with Pubmed ID, gene symbol/accession number and viral interacting
protein. Thank you.
Viral proteins CORE, E1, E2, P7: NS2 NS3 NS4A NS4B , NS5A, NS5B ,
F protein
Many of these genes are the subject of bulk siRNA studies Li
et al, 2009 , and from a review by De
Chassey et al, 2008 and are also derived from the Hepatitis
C Virus Protein Interaction Database (HCVpro)
Kwofie
et al, 2011 to which new interactions have been added.
AADAC arylacetamide deacetylase: Viral production reduced by AADAC
knockdown in JFH-1/Huh7.5 cells Nourbakhsh
et al, 2013
AAK1 AP2 associated kinase 1: AAK1 and GAK regulate HCV assembly
by stimulating binding of the µ subunit of AP-2, AP2M1, to
HCV core protein Neveu
et al, 2014 .
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 : ABCA1-stimulation
inhibits viral cell entry Bocchetta
et al, 2014
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 :
siRNA knockdown decreases infection Li
et al, 2009
ABHD2 abhydrolase domain containing 2: siRNA knockdown decreases
infection Li
et al, 2009
ACY3 aspartoacylase (aminocyclase) 3: Binds to and cleaves CORE
protein Tsirulnikov
et al, 2012
ADAMTS4 ADAM metallopeptidase with thrombospondin type 1 motif,
4: siRNA knockdown decreases infection Li
et al, 2009
ADAR adenosine deaminase, RNA-specific: interacts with viral 5'
terminal untranslated RNA Li
et al, 2014
AEBP1 adipocyte enhancer binding protein 1: interacts with NS3
protein De
Chassey et al, 2008
ADI1 acireductone dioxygenase 1:physical interaction between MMP14and
ADI1 led to suppression of HCV infection. This inhibitory effect
could be reversed by ADI1 overexpression.Chang
et al, 2015.
ADK adenosine kinase: inolved in the antiviral activity of ribavirin.Mori
et al, 2013
AGO1– argonaute RISC catalytic component 1: miR-122 recruits
Ago1 and AGO2 to the 5'-UTR of the internal ribosome entry site
Conrad
et al, 2013
AGO2 – argonaute RISC catalytic component 2: see AGO1
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3: siRNA knockdown
decreases infection Li
et al, 2009
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member
8) interacts with F protein Huang
et al, 2005
AHNAK AHNAK nucleoprotein interacts with NS5A protein Ahn
et al, 2004
AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog
1 interacts with NS5A protein Randall
et al, 2007
AICDA activation-induced cytidine deaminase: activated by the
viris via NFKB1 Endo
et al, 2007
ALAD aminolevulinate dehydratase: siRNA knockdown decreases infection
Li
et al, 2009
ALDH1A1 aldehyde dehydrogenase 1 family, member A1: (retinaldehyde
dehydrogenase) upregulated in in HCV replicon-harboring cells Koike
et al, 2012
ALG13 asparagine-linked glycosylation 13 homolog (S. cerevisiae)
(Ex CXorf45) interacts with NS3 protein De
Chassey et al, 2008
AKT1 v-akt murine thymoma viral oncogene homolog 1 interacts with
NS5A protein Randall
et al, 2007
AMMECR1L AMME chromosomal region gene 1-like: siRNA knockdown
decreases infection Li
et al, 2009
ANGPTL3 – angiopoietin-like 3: HCV core represses expression
via loss of HNF-1a binding activity and blockage of LXR/RXR transactivation
Foka
et al, 2013
ANXA5 annexin A5: Component of the viral replication complex Park
et al, 2013
AP1GBP1: AP1 gamma subunit binding protein 1: siRNA knockdown
decreases infection Li
et al, 2009
AP3B1: adaptor-related protein complex 3, beta 1 subunit: siRNA
knockdown decreases infection Li
et al, 2009
APAF1 apoptotic peptidase activating factor 1 : Core-expressing
apoptotic cells indicated a significant increase in the level of
Apaf-1, coinciding with caspase-9 activation Meyer
et al, 2005
APC2 adenomatosis polyposis coli 2: siRNA knockdown decreases
infection Li
et al, 2009
APH1A Gamma secretase (APH1A, PSEN1, PSEN2, PSENEN, NCSTN) cleaves
the viral receptor LDLR and SDC2 Lleó
and Saura, 2011
APLP2: amyloid beta (A4) precursor-like protein 2: siRNA knockdown
decreases infection Li
et al, 2009
AP2M1 mediator of HCV clathrin-dependent endocytosis (siRNA study)
Coller
et al, 2009
APOA1 apolipoprotein A-I interacts with NS5A protein Shi
et al, 2002
ATF6B activating transcription factor 6 beta (CREBL1) interacts
with NS4B protein Tong
et al, 2002
ATG4B autophagy related 4B, cysteine peptidase : autophagy related
: autophagy proteins (Beclin-1, Atg4B, Atg5, and Atg12) are proviral
factors required for translation of incoming HCV RNA and for initiation
of HCV replication Dreux
et al, 2009
ATG5 autophagy related 5 :autophagy related : autophagy proteins
(Beclin-1, Atg4B, Atg5, and Atg12) are proviral factors required
for translation of incoming HCV RNA and for initiation of HCV replication
Dreux
et al, 2009 interacts with NS5B Guévin
et al, 2010
ATG7 ATG7 autophagy related 7 homolog (S. cerevisiae) knockdown
decreases release of viral particles Tanida
et al, 2009
ATG12 autophagy related 12: autophagy related : autophagy proteins
(Beclin-1, Atg4B, Atg5, and Atg12) are proviral factors required
for translation of incoming HCV RNA and for initiation of HCV replication
Dreux
et al, 2009
ATM ataxia telangiectasia mutated required for viral RNA replication
Ariumi
et al, 2008
ATP (adenosine triphosphate): cells involved in viral RNA replication
consume ATP reducing cytoplasmic ATP levels Ando
et al, 2012
ATP10D ATPase, class V, type 10D : siRNA knockdown decreases infection
Li
et al, 2009
ATP11A ATPase, class VI, type 11A : siRNA knockdown increases
infection Li
et al, 2009
ATP6V0A1 A TPase, H+ transporting, lysosomal V0 subunit a1: mediator
of HCV clathrin-dependent endocytosis (siRNA study) Coller
et al, 2009
ATXN2 – ataxin 2: stress granule component distributed to
the HCV production factory Ariumi
et al, 2011
AZGP1 alpha-2-glycoprotein 1, zinc-binding interacts with F protein
Huang et al, 2005
BAX BCL2-associated X protein: HCV infection induces apoptosis
of the host cell through a Bax-triggered, mitochondrion-mediated,
caspase 3-dependent pathway in in Huh7.5 cells Deng
et al, 2008
BAD BCL2-associated agonist of cell death: The core protein releases
cytochrome c from isolated mitochondria when complemented with Bad
Mohd-Ismail
et al, 2009
BAGE2: B melanoma antigen family, member 2: siRNA knockdown decreases
infection Li
et al, 2009
BECN1 beclin-1 knockdown decreases release of viral particles
Tanida
et al, 2009 autophagy related : autophagy proteins (Beclin-1,
Atg4B, Atg5, and Atg12) are proviral factors required for translation
of incoming HCV RNA and for initiation of HCV replication Dreux
et al, 2009
BEND5 BEN domain containing 5 (C1orf165) interacts with NS3 protein
De
Chassey et al, 2008
BEND7 BEN domain containing 7 (C10orf30) interacts with NS5A protein
De
Chassey et al, 2008
BID BH3 interacting domain death agonist Calpains activated by
HCV proteins degrade Bid Simonin
et al, 2009
BIK BCL2-interacting killer (apoptosis-inducing): BIK is essential
for HCV replication and NS5B induces BIK expression in hepatocytes
Aweya
et al, 2015.
BIN1 bridging integrator 1 interacts with NS5A protein Zech
et al, 2003
BMP7 bone morphogenetic protein 7 suppresses viral replication
Sakamoto
et al, 2007
BRF1: BRF1 homolog, subunit of RNA polymerase III transcription
initiation factor IIB: siRNA knockdown decreases infection Li
et al, 2009
BROX BRO1 domain and CAAX motif containing knockdown suppressees
infectivity Ariumi
et al, 2011
BRUNOL6: bruno-like 6, RNA binding protein (Drosophila): siRNA
knockdown decreases infection Li
et al, 2009
BST2 bone marrow stromal cell antigen 2 : Restricts viral production
Amet
et al, 2013
BZRAP1 benzodiazapine receptor (peripheral) associated protein
1 interacts with NS3 protein De
Chassey et al, 2008
C1orf94 chromosome 1 open reading frame 94 interacts with NS3
protein De
Chassey et al, 2008
C1QBP complement component 1, q subcomponent binding protein interacts
with CORE protein Kittlesen
et al, 2000
C3 complement component 3: The NS5A protein downregulates C3 promoter
activity Mazumdar
et al, 2011
C4A complement component 4A (Rodgers blood group) : Gamma chain
cleaved by the viral NS3/4A Protease Mawatari
et al, 2013
CASP9 caspase 9: Core-expressing apoptotic cells indicated a significant
increase in the level of Apaf-1, which coincides with caspase-9
activation Meyer
et al, 2005
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence
mediator of HCV clathrin-dependent endocytosis (siRNA study) Coller
et al, 2009
CCDC8: coiled-coil domain containing 8 (CCDC21) : siRNA knockdown
decreases infection Li
et al, 2009
CD2AP CD2-associated protein: interacts with the viral NS5A protein
and a candidate for a role in NS5A-mediated perturbation of EGFR
trafficking Igloi
et al, 2015
CD36 co-receptor for hepatitis C virus E1 protein attachment Cheng
et al, 2016.
CCDC37 coiled-coil domain containing 37 interacts with NS3 protein
De
Chassey et al, 2008
CCDC66 coiled-coil domain containing 66 interacts with NS3 protein
De
Chassey et al, 2008
CCDC86 coiled-coil domain containing 86 (ex MGC2574) interacts
with NS5A protein Ahn
et al, 2004
CCHCR1 coiled-coil alpha-helical rod protein 1 interacts with
NS3 protein De
Chassey et al, 2008
CCL2 chemokine (C-C motif) ligand 2 (MCP-1) core and NS5A increase
promoter activities of MCP-1 and RANTES Soo
et al, 2002
CCL3 Chemokines secreted by infected hepatocytes are mainly associated
with the T-helper cell response and include CCL3 (macrophage inflammatory
protein-1 alpha), CCL4 (MIP-1 beta), CCL5 (RANTES), CXCL10 (interferon-gamma-inducible
protein-10; IP-10), CXCL11 (interferon-inducible T-cell alpha chemoattractant;
I-TAC), and CXCL9 (monokine induced by interferon gamma; Mig) which
recruit T cells expressing either CCR5 or CXCR3 chemokine receptors
Larubia
et al, 2008
CCL5 chemokine (C-C motif) ligand 5 (RANTES) E2 binding to CD81
increases CCL5 release and promotes CCR5 internalisation Natterman
et al, 2004 See Larubia
et al, 2008
CCL17 chemokine (C-C motif) ligand 17: The virus induces expression
of CCL17 and CCL22, attracting T cells to infection sites Riezu-Boj
et al, 2011
CCL20 chemokine (C-C motif) ligand 20: chemokine (C-C motif) ligand
20 : Expression reduced by the CORE protein in hepatocytes Nguyen
et al, 2006
CCL21 chemokine (C-C motif) ligand 22 : Modifies lymphocyte recruitment
in infection
Bonacchi et al,2003 Expression of CCL21 in lymphoid areas and
CCR7 in T lymphocytes up-regulated in infected patients Bonacchi
et al, 2003
CCL22 The virus induces expression of CCL17 and CCL22, attracting
T cells to infection sites Riezu-Boj
et al, 2011
CCL26 chemokine (C-C motif) ligand 26: siRNA knockdown decreases
infection Li
et al, 2009
CCPG1: cell cycle progression 1: siRNA knockdown decreases infection
Li
et al, 2009
CCR1 chemokine (C-C motif) receptor 1 : Blood mRNA levels of CCR1,
CCR2, CCR3, and CCR5 in patients with minimal histological manifestations
of chronic HCV-infection lower than in patients with more marked
lesions Zhdanov
et al, 2008
CCR2 chemokine (C-C motif) receptor 2 the G190A polymorphism in
the first transmembrane domain of CCR2 was under-represented in
patients who had cleared the hepatitis C virus spontaneously Mascheretti
et al, 2004 see also Zhdanov
et al, 2008
CCR5 chemokine (C-C motif) receptor 5: E2 binding to CD81 increases
CCL5 release and promotes CCR5 internalisation Natterman
et al, 2004
CCR7 chemokine (C-C motif) receptor 7: expression of CCL21 in
lymphoid areas and CCR7 in T lymphocytes up-regulated in infected
patients Bonacchi
et al, 2003
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) binds to
NS5B Inoue
et al, 2011
CD1A HCV core andNS3 proteins inhibit the expression of CD1A,
CD1B and DC-SIGN (CD209) during monocyte differentiation to dendritic
cells ,and increase macrophage markers (CD14 and HLA-DR) and PD-L1
(CD274) expression Tu
et al, 2012
CD14 monocyte differentiation antigen CD14 see Tu
et al, 2012
CD33 CD33 molecule (SIGLEC family) CD33(+) mononuclear cells co-cultured
with HCV-infected hepatocytes, or with the core protein, suppress
autologous T cell responses.Tacke
et al, 2011: In hepatitis infected livers, Kupffer cell/macrophage
activation is indicated by increased CD163 and CD33 expression Dolganiuc
et al, 2007.
CD40 TNF receptor superfamily member 5: CD40 and its ligand CD40LG
inhibit viral replication Rau
et al, 2013
CD44 CD44 molecule (Indian blood group): Involved, with TLR2 in
the induction of chemokine IP10 (CXCL10) by infection Abe
et al, 2012
CD55 CD55 molecule, decay accelerating factor for complement (Cromer
blood group) : Transgenic mice conditionally expressing the HCV
core protein develop inflammation, steatosis, and fibrosis which
are reduced by administration of CD55 Chang
et al, 2009
CD59 complement regulatory protein: incorporated into the virion
Amet
et al, 2011
CD274 The virus acts as a ligand for TLR2 on human Kuppfer cells
, which then secrete interleukin IL1B , TNF-alpha (TNF) , and IL10
and up-regulate cell surface CD274 : (PD-L1) Tu
et al, 2010.
CDCA3 cell division cycle associated 3: siRNA knockdown decreases
infection Li
et al, 2009
CDC6: cell division cycle 6 homolog (S. cerevisiae): siRNA knockdown
decreases infection Li
et al, 2009
CDC23 cell division cycle 23, yeast, homolog: interacts with NS3
protein De
Chassey et al, 2008
CDC42 mediator of HCV clathrin-dependent endocytosis (siRNA study)
Coller
et al, 2009
CDH1: cadherin 1, type 1, E-cadherin (epithelial): siRNA knockdown
decreases infection Li
et al, 2009
CDK1 cyclin-dependent kinase 1: interacts with NS5A protein Arima
et al, 2001
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35) binds
to the viral genome Luo,
1999
CDK6 cyclin-dependent kinase 6: interacts with NS5A protein Randall
et al, 2007
CDKL5: cyclin-dependent kinase-like 5: siRNA knockdown decreases
infection Li
et al, 2009
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1): interacts
with CORE protein Wang
et al, 2000
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1): The CORE
protein stabilises p27(Kip1) which inhibits T cell proliferation
Yao
et al, 2003.
CDKN2A cyclin-dependent kinase inhibitor 2A: Core protein down-regulates
CDKN2A (p16) levels of p16, resulting in inactivation of RB1 and
subsequent activation of E2F1, an effect mediated via up-regulation
of DNA methyltransferases DNMT1 and DNMT3B in hepatoctes Park
et al, 2011
CELA3A chymotrypsin-like elastase family, member 3A: binds to
core protein Zhang
et al, 2009
CELSR2 cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo
homolog, Drosophila): interacts with NS3 protein De
Chassey et al, 2008
CH25H cholesterol 25-hydroxylase: 25-hydroxycholesterol and its
synthesizing enzyme CH25H inhibit HCV infection at a post-entry
stage via suppressing the maturation of transcription factor SREBPs
that regulate lipid biosynthesis Xiang
et al, 2015.
CHKA: choline kinase alpha: siRNA knockdown decreases infection
Li
et al, 2009
CHMP4B charged multivesicular body protein 4B: binds to CORE protein
Ariumi
et al, 2011
COL4A3BP collagen, type IV, alpha 3 (Goodpasture antigen) binding
protein (also functions as a ceramide transfer protein) Controls
viral secretion from the Golgi Bishé
et al, 2012
CR1 complement component (3b/4b) receptor 1 (Knops blood group)
:plays a general role in the clearance of antibody bound pathogens:
expression of erythrocyte CR1 is related to immune complex quantity
and the severity of liver disease in hepatitis C virus infection
Kanto
et al, 1996. Also part of a viral receptor complex on B cells
Wang
et al, 2016
CR2 complement C3d receptor 2 : Complement system: Involved in
the association of the virus to B cells. complement proteins C1,
C2, and C3 , and to a lesser extent C4 are required to activate
this binding. The binding complex mainly involved CR2 (complement
receptor 2), CD19, CD20 = MS4A1, and CD81; CR1 was involved but
had lower binding activity Wang
et al, 2016.
CRABP1 cellular retinoic acid binding protein I: interacts with
NS5A protein Ahn
et al, 2004
CTAGE6: CTAGE family, member 6: siRNA knockdown decreases infection
Li
et al, 2009
CTGF: connective tissue growth factor: siRNA knockdown decreases
infection Li
et al, 2009
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa: beta-Catenin-mediated
transcriptional activity is elevated by NS5A protein Park
et al, 2009
CXCR4 CXCL12 and its receptor CXCR4 involved in the recruitment
of immune cells during infection Wald
et al, 2004
CXorf22 chromosome X open reading frame 22: siRNA knockdown decreases
infection Li
et al, 2009
CYBA: cytochrome b-245, alpha polypeptide: siRNA knockdown decreases
infection Li
et al, 2009
CYCS cytochrome c, somatic: mitochondrial cytochrome C released
by BAX activation by the virus Deng
et al, 2008
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1(aryl
hydrocarbon hydroxylase): NS5A suppresses CYP1A1 protein and enzyme
activity induced by the arylhydrocarbon receptor (AHR) ligand, 2,3,7,8-tetrachlorodibenzo-p-dioxin
Anderson
et al, 2006
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6 (coumarin
7-hydroxylase): Molecular mimicry by a viral protein and autoantibody
in viral hepatitis Kammer
et al, 1999
CYP2A7 cytochrome P450, family 2, subfamily A, polypeptide 7:
Molecular mimicry by a viral protein and autoantibody in viral hepatitis
Kammer
et al, 1999
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6:
Molecular mimicry by a viral protein and autoantibody in viral hepatitis
Dalekos
et al, 1999
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 Molecular
mimicry by a viral protein and autoantibody in viral hepatitis Rigamonti
et al, 2009
CYP4A22: cytochrome P450, family 4, subfamily A, polypeptide 22:
siRNA knockdown decreases infection Li
et al, 2009
DACT3: dapper, antagonist of beta-catenin, homolog 3 (Xenopus
laevis): siRNA knockdown decreases infection Li
et al, 2009
DBNDD1: dysbindin (dystrobrevin binding protein 1) domain containing
1: siRNA knockdown decreases infection Li
et al, 2009
DCAF6 DDB1 and CUL4 associated factor 6 (ex IQWD1) : interacts
with NS3 protein De
Chassey et al, 2008
DDB1 damage-specific DNA binding protein 1, 127kDa: substrate
of NS3/4A protease required for viral replication
DDOST dolichyl-diphosphooligosaccharide--protein glycosyltransferase:
siRNA knockdown decreases infection Li
et al, 2009
DDX3X DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked interacts
with core protein Sun
et al, 2010 : siRNA knockdown decreases infection Li
et al, 2009
DDX3Y DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked interacts
with CORE protein De
Chassey et al, 2008
DDX5 DEAD (Asp-Glu-Ala-Asp) box polypeptide 5 binds to CORE, NS5B
De
Chassey et al, 2008
DDX6 DEAD (Asp-Glu-Ala-Asp) box polypeptide 6 (RCK/p54) regulates
viral translation Scheller
et al, 2009
DDX25 – DEAD (Asp-Glu-Ala-Asp) box helicase 25: Component
of the viral replication complex Park
et al, 2013
DDX58 (RIG-1 viral DNA sensor) binds to the polyuridine motif
of the HCV genome 3' non-translated region Saito
et al, 2008
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like: inhibits
viral replication Grünvogel
et al, 2015
DEAF1 deformed epidermal autoregulatory factor 1 (Drosophila)
interacts with NS3 protein De
Chassey et al, 2008
DEFA5: defensin, alpha 5, Paneth cell-specific : siRNA knockdown
decreases infection Li
et al, 2009
DEFB126: defensin, beta 126DEFB126: defensin, beta 126: siRNA
knockdown decreases infection Li
et al, 2009
DGAT1 diacylglycerol O-acyltransferase 1 required for viral particle
formation Herker
et al, 2010 : siRNA knockdown decreases infection Li
et al, 2009
DHCR7 7-dehydrocholesterol reductase: knockout or inhibition reduces
steady-state HCV protein expression and viral genomic RNA Rodgers
et al, 2012.
DHCR24 24-dehydrocholesterol reductase (seladin) an antibody to
DHCR24 has antiviral activity both in vitro and in vivo in mice
Satoh
et al, 2011 : Upregulated by infection: Saito
et al, 2012
DHRS12: dehydrogenase/reductase (SDR family) member 12: siRNA
knockdown decreases infection Li
et al, 2009
DHX9 DEAH (Asp-Glu-Ala-His) box polypeptide 9: RNA helicase A
involved in viral RNA replication Isken
et al, 2007
DICER1 dicer 1, ribonuclease type III interacts with CORE protein
Wang
et al, 2006
DIO3: deiodinase, iodothyronine, type III: siRNA knockdown decreases
infection Li
et al, 2009
DLAT dihydrolipoamide S-acetyltransferase interacts with NS3
protein De
Chassey et al, 2008
DLG1 – discs, large homolog 1 : The HCV core protein, expressed
in Huh7 and MDCK cells, disrupted apicobasal polarity and decreased
the expression of the polarity protein Dlg1 and the PI phosphatase
INPPL1 Awad
et al, 2013
DLGAP4: discs, large (Drosophila) homolog-associated protein 4:
siRNA knockdown decreases infection Li
et al, 200
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 interacts with
NS5A protein De
Chassey et al, 2008
DNAJB1: DnaJ (Hsp40) homolog, subfamily B, member 1: siRNA knockdown
decreases infection Li
et al, 200
DNM2 dynamin complexes with occludin and plays a role in HCV entry
Liu
et al, 2010
DNMT1 DNA (cytosine-5-)-methyltransferase 1: and DNMT3B DNA (cytosine-5-)-methyltransferase
3 beta: Knockdown inhibits replication in Huh7.5.1 cells Chen
et al, 2013
DOCK3: dedicator of cytokinesis 3: siRNA knockdown decreases infection
Li
et al, 200
DUSP1 dual specificity phosphatase 1 : Suppression inhibits hepatitis
C virus replication Choi
et al, 2015.
E2F2: E2F transcription factor 2: siRNA knockdown decreases infection
Li
et al, 200
ECI1 (aka DDI) enoyl-CoA delta isomerase 1 Required for viral
replication Rasmussen
et al, 2011
EDEM1 ER degradation enhancer, mannosidase alpha-like 1: EDEM1
and EDEM3 increase the ubiquitylation of HCV envelope proteins via
physical interaction. EDEM1/EDEM3 knockdown increases the half-life
of the HCV E2 protein Saeed
et al, 2011
EDEM3 ER degradation enhancer, mannosidase alpha-like 3 ""
EEF1A1 eukaryotic translation elongation factor 1 alpha 1: interacts
with NS3 protein De
Chassey et al, 2008
EFEMP1 EGF containing fibulin-like extracellular matrix protein
1 binds to NS3, NS5A De
Chassey et al, 2008
EFEMP2 EGF containing fibulin-like extracellular matrix protein
2: interacts with NS3 protein De
Chassey et al, 2008
EFTUD2 elongation factor Tu GTP binding domain containing 2: exerts
antiviral activity via its downstream regulators RIG-I and MDA5
by gene splicing to activate IRF3 Zhu
et al, 2015
EGR1 early growth response 1 activated by CORE protein Lee
et al, 2001
EIF1 eukaryotic translation initiation factor 1 interacts with
NS3 protein De
Chassey et al, 2008
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase
2 (PKR) binds to E2, NS5A De
Chassey et al, 2008
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase
3 (PERK) interacts with E2 protein Pavio
et al, 2003
EIF2B3 eukaryotic translation initiation factor 2B, subunit 3
gamma, 58kDa: RNA silencing (EIF2B3, SSB or VAPA) inhibits the replication
and expression of HCV in Huh7 cells Wang
et al, 2012
EIF2C1 eukaryotic translation initiation factor 2C, (argonaute
AGO1) The virus uses host cellular RNAi machinery, including miRNA-122,
Ago1-4, and Dicer proteins for replication and viral genome translation
in Huh7 cells
Berezhna et al, 2011
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha,
35kDa, binds to ires Kim
et al, 2011
EIF3A: eukaryotic translation initiation factor 3, subunit A:
EIF3 binds to ires and is involved in viral RNA translation Cai
et al, 2010 : EIF3 is a 13 subunit complex Zhou
et al 2008 consisting of:- EIF3A EIF3B EIF3C EIF3D EIF3E EIF3F
EIF3G EIF3H EIF3I EIF3J EIF3K EIF3L EIF3M
EIF4A2 eukaryotic translation initiation factor 4A2 interacts
with NS5B protein Kyono
et al, 2002
EIF4E eukaryotic translation initiation factor 4E: Phosphorylated
by NS5A George
et al, 2011
EIF4EBP1 overexpression of eukaryotic translation initiation factor
4E-binding protein 1 increases cap-independent viral translation
and viral RNA abundance Ishida
et al, 2007
EIF4ENIF1 eukaryotic translation initiation factor 4E nuclear
import factor 1 interacts with NS3 protein De
Chassey et al, 2008
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog
2, neuro/glioblastoma derived oncogene homolog (avian): involved
in the carcinogenic effects of the viral non-structural protein
NS3P Bahnassi
et al, 2005
ERC1 ELKS/RAB6-interacting/CAST family member 1 interacts with
NS3 protein Hidajat
et al, 2005
ERC2: ELKS/RAB6-interacting/CAST family member 2: siRNA knockdown
decreases infection Li
et al, 2009
ERCC5: excision repair cross-complementing rodent repair deficiency,
complementation group 5 (xeroderma pigmentosum, complementation
group G (Cockayne syndrome)): siRNA knockdown decreases infection
Li
et al, 2009
ERN1 endoplasmic reticulum to nucleus signaling 1 NS4B induces
activating transcription factor (ATF6) and inositol-requiring enzyme
1 (ERN1) resulting in XBP1 splicing Zheng
et al, 2005
Endosomal Sorting Complex Required for Transport (ESCRT) Machinery
interactions: Diverse viral proteins bind to CHMP1A CHMP4B HGS SLC9A6
VPS4A Barouch-Bentov
et al, 2016
17ß-estradiol inhibits the production of infectious
viral particles Hayashida
et al, 2010
ETF1: eukaryotic translation termination factor 1: siRNA knockdown
decreases infection Li
et al, 2009
Ethanol increases HCV replication via upregulation of TNRC6A and
HSP90 in human hepatoma cells Bukong
et al, 2012
EWSR1 Ewing sarcoma breakpoint region 1 binds to internal ribosomal
entry site.Lu
et al, 2004 : siRNA knockdown decreases infection Li
et al, 2009
EXOC3L4 exocyst complex component 3-like 4 (C14orf173) interacts
with NS3 protein De
Chassey et al, 2008
EZR – ezrin: HCV E2 protein induces rapid ezrin phosphorylation
and its cellular redistribution with F-actin via spleen tyrosine
kinase (SYK): Bukong
et al, 2013
FADD Fas (TNFRSF6)-associated via death domain interacts with
CORE protein Zhu
et al, 2001
FAM120B family with sequence similarity 120B interacts with NS3
protein De
Chassey et al, 2008
FAM65A family with sequence similarity 65, member A interacts
with NS3 protein De
Chassey et al, 2008
FAM116A family with sequence similarity 116, member A: siRNA knockdown
decreases infection Li
et al, 2009
FAM178A (C10orf6) family with sequence similarity 178, member
A interacts with NS3 protein De
Chassey et al, 2008
FAM206A family with sequence similarity 206, member A (C9orf6)
interacts with NS5A protein Ahn
et al, 2004
FAS Fas (TNF receptor superfamily, member 6) interacts with CORE
protein Moorman
et al, 2003
FASN fatty acid synthase: HCV-induced production of fatty acids
and neutral lipids is provided by an increase in FASN abundance
and activity, allow HCV propagation without transporting FASN to
the replication complexes Nasheri
et al, 2013.
FAU: Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously
expressed (fox derived); ribosomal protein S30: siRNA knockdown
decreases infection Li
et al, 2009
FCGRT: Fc fragment of IgG, receptor, transporter, alpha: siRNA
knockdown decreases infection Li
et al, 2009
FCN2 ficolin (collagen/fibrinogen domain containing lectin) 2:
neutralized and inhibited initial attachment and infection of HCV
by binding to the HCV envelope surface glycoproteins E1 and E2 Zhao
et al, 2014
FER1L3: fer-1-like 3, myoferlin (C. elegans): siRNA knockdown
decreases infection Li
et al, 2009
FOS FBJ murine osteosarcoma viral oncogene homolog (c-fos) Regulates
viral propagation Kang
et al, 2011
FOXA2 forkhead box A2: HCV infection of human hepatocytes blocks
insulin-induced FoxO1 translocation from the nucleus to the cytoplasm
and reduces accumulation of FoxA2 in the nucleus Banerjee
et al, 2010 siRNA knockdown decreases infection Li
et al, 2009
FOXE3 forkhead box E3: siRNA knockdown decreases infection Li
et al, 2009
FOXO1 forkhead box O1: HCV infection of human hepatocytes blocks
insulin-induced FoxO1 translocation from the nucleus to the cytoplasm
and reduces accumulation of FoxA2 in the nucleus Banerjee
et al, 2010
FRMPD3: FERM and PDZ domain containing 3: siRNA knockdown decreases
infection Li
et al, 2009
FRMPD4 FERM and PDZ domain containing 4 interacts with NS3 protein
De
Chassey et al, 2008
FRS3 fibroblast growth factor receptor substrate 3: interacts
with NS3 protein De
Chassey et al, 2008
FDFT1 farnesyl-diphosphate farnesyltransferase 1: knockdown impairs
HCV replication in subgenomic replicon and HCV cell culture derived
infected cells Park
et al, 2014
GAB1 GRB2-associated binding protein 1: Complexes with NS5A He
et al, 2002
GAK cyclin G associated kinase: AAK1 and GAK regulate HCV assembly
by stimulating binding of the µ subunit of AP-2, AP2M1, to
HCV core protein Neveu
et al, 2014 .
GAPDH glyceraldehyde-3-phosphate dehydrogenase interacts with
CORE protein De
Chassey et al, 2008
GBF1 golgi brefeldin A resistant guanine nucleotide exchange factor
1: Supports viral replication Zhang
et al, 2012
GBP1 guanylate binding protein 1, interferon-inducible siRNA knockdown
increases replication Itsui
et al, 2006
GBP2 guanylate binding protein 2, interferon-inducible interacts
with NS3 protein De
Chassey et al, 2008
GCAT glycine C-acetyltransferase : siRNA knockdown decreases infection
Li
et al, 2009
GEMIN5 gem (nuclear organelle) associated protein 5 binds to ires
Pacheco
et al, 2009
GOLM1 golgi membrane protein 1 (GP73) : Cellular viral production
enhanced when GOLM1 was overexpressed, and inhibited by GOLM1 silencing
Hu
et al, 2014
GOLPH3 golgi phosphoprotein 3 (coat-protein): Silencing GOLPH3
or MYO18A reduces HCV virion secretion Bishé
et al, 2012
GSK3A glycogen synthase kinase 3 alpha interacts with NS5A protein
Randall
et al, 2007
GSK3B glycogen synthase kinase 3 beta interacts with NS5A protein
Randall
et al, 2007
GTF3A: general transcription factor IIIA: siRNA knockdown decreases
infection Li
et al, 2009
GUCY1A2: guanylate cyclase 1, soluble, alpha 2: siRNA knockdown
decreases infection Li
et al, 2009
H19 H19, imprinted maternally expressed transcript (non-protein
coding) interacts with p7 protein Huang
et al, 2005
HAMP hepcidin antimicrobial peptide : HCV core protein up-regulates
HAMP gene transcription via a complex signaling network that requires
both SMAD/BMP and STAT3 pathways and CK2 involvement Foka
et al, 2014.
HAO1 hydroxyacid oxidase (glycolate oxidase) 1 interacts with
NS5B protein Lan
et al, 2003
HBEGF heparin-binding EGF-like growth factor: The CORE protein
activates Akt1 via the Ras/PI(3)K pathway by autocrine secretion
of HBEGF. Nakamura et al, 2011
RSF1 remodeling and spacing factor 1 (HBXAP) interacts with CORE
protein Chen
et al, 2003
HCCS: holocytochrome c synthase (cytochrome c heme-lyase): siRNA
knockdown decreases infection Li
et al, 2009
HLA-A major histocompatibility complex, class I, A interacts with
CORE protein Natterman
et al, 2005
HLA-A2 recognises epitopesderived from HCV nonstructural proteins
(NS) 3 and 5B (NS3(1406-1415) and NS5B(2594-2602)). Wölk
et al, 2012
HLA-E major histocompatibility complex, class I, E interacts with
CORE protein Natterman
et al, 2005
HM13 histocompatibility (minor) 13 part of a signal peptidase
that processes the hepatitis C virus core protein Weihofen
et al, 2002
HMGB1 high mobility group box 1 is released from infected cells
and blocks infection Jung
et al, 2011
Pharmacological epistasis between inhibitors of the sterol synthesis
or prenylation pathway which block viral replication Owens
et al, 2010 involving HMGCR, FDPS FPPS , SQLS, SQLE, LSS, CYP51A1
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase : Inhibition disrupts
viral replication Ye
et al, 2003
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) Cestatin
inhibits this enzyme and blocks viral replication Peng
et al, 2011 Component of the viral replication complex Park
et al, 2013
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
Cestatin inhibits this enzyme and blocks viral replication Peng
et al, 2011
HMOX1 heme oxygenase (decycling) 1: Lucidone suppressesviral replication
via Nrf2-mediated (NFE2L2) heme oxygenase-1 induction Chen
et al, 2013.
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) binds
to the viral genome Gontarek
et al, 1999
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) binds to
core protein Lee
et al, 2011
HNRNPK heterogeneous nuclear ribonucleoprotein K binds to CORE
and NS3 De
Chassey et al, 2008 : siRNA knockdown increases infection Li
et al, 2009
HNRNPL heterogeneous nuclear ribonucleoprotein L: interacts with
viral 5' terminal untranslated RNA Li
et al, 2014
HRAS coinfection of at embryo fibroblast cells with HRAS and the
core protein became transformed and exhibited rapid proliferation,
anchor-independent growth, and tumor formation in athymic nude mice
Ray
et al, 1996
HRC: histidine rich calcium binding protein: siRNA knockdown decreases
infection Li
et al, 2009
HSPA1A heat shock 70kDa protein 1A : Interacts with NS5A Lim
et al, 2012
HSPA8 heat shock 70kDa protein 8: binds to NS5A: intracellular
infectious virion assembly impaired by knockdown Khachatoorian
et al, 2014.
PRMT1 protein arginine methyltransferase 1 (ex HRMT1L2) interacts
with NS3 protein Rho
et al, 2001
HOXB13 homeobox B13: siRNA knockdown decreases infection Li
et al, 2009
HSD17B13: hydroxysteroid (17-beta) dehydrogenase 13: siRNA knockdown
decreases infection Li
et al, 2009
HSPA1A heat shock 70kDa protein 1A (hsp72) interacts with NS5A
Chen
et al, 2010 : siRNA knockdown decreases infection Li
et al, 2009
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
promoter activated by NS2 von
dem Bussche et al, 2010
HSPA12A heat shock protein family A (Hsp70) member 12A: Viral
E2 protein induced production of several heat shock proteins including
HSPD1, HSP12A and HSPE1 in human primary thyrocytes Hammerstad
et al, 2016
HSPB1 heat shock 27kDa protein 1 (hsp27) binds to NS5A Choi
et al, 2004
HSPD1 heat shock 60kDa protein 1 (chaperonin) interacts with CORE
protein Kang
et al, 2005
HSPE1 heat shock protein family E (Hsp10) member 1 : Viral E2
protein induced production of several heat shock proteins including
HSPD1, HSP12A and HSPE1 in human primary thyrocytes Hammerstad
et al, 2016
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1: blocks
viral induced apoptosis Lee
et al, 2008
IDO1 indoleamine 2,3-dioxygenase 1: Upregulated by infection in
Huh7 liver cells and in infected patients Larrea
et al, 2007
IFI6 interferon, alpha-inducible protein 6: siRNA knockdown increases
replication Itsui
et al, 2006
IFI27 interferon, alpha-inducible protein 27: siRNA knockdown
increases replication Itsui
et al, 2006
IFIH1 interferon induced with helicase C domain 1 senses viral
RNA Qu
and Lemon, 2010
IFIT1 interferon-induced protein with tetratricopeptide repeats
1: inhibits viral replication Raychoudhuri
et al, 2011
IFITM1 interferon induced transmembrane protein 1 (9-27): inhibits
viral replication Raychoudhuri
et al, 2011
IFITM2 interferon induced transmembrane protein 2: IFITM1, IFITM2,
and IFITM3 Inhibit Hepatitis C Virus Entry Narayana
et al, 2015 .
IFITM3: interferon induced transmembrane protein 3 (1-8U) : siRNA
knockdown decreases infection Li
et al, 2009
IFNA1 interferon, alpha 1 : suppresses viral infection via activation
of numerous effector genes Fusco
et al, 2013
IFNG interferon gamma: Upregulated in natural killer cells by
infection Farag
et al, 2011
IGF2 insulin-like growth factor 2 (somatomedin A) activated by
CORE protein via EGR1 and SP1 Lee
et al, 2001
IFNA1 Interferon alpha1: ALG10, BCHE, DPP4, GCKR, GUCY1B3, MYST1,
PPP3CB, PDIP1, SLC27A2 enable IFN-a-mediated suppression of the
virus in hepatoma cells Fusco
et al, 2013
IFNA2 interferon, alpha 2: Polymorphism associated with infection
Tena-Tomás
et al, 2008
IFNAR1 interferon (alpha, beta and omega) receptor 1: expression
necessary for vciral responses to interferon alpha Datta
et al, 2011
IFNAR2 interferon (alpha, beta and omega) receptor 2: Liver expression
predicts repsonse to interferon alpha Fujiwara
et al, 2004
IFNB1 interferon, beta 1, fibroblast: DDX3 dependent induction
prevented by the core protein Oshiumi
et al, 2010
IFNL2 interferon, lambda (previously IL28A interleukin 28A 2)
: IL28A and IL29 are up-regulated in infected patients, induce antiviral
genes and inhibit viral replication Diegelmann
et al, 2010.
IFNL3 (previuosly IL28B interleukin 28B) interferon, lambda 3
: Hepatic expressions of viral sensors and modulators is modified
by IL28B polymorphisms in infected patients Asahina
et al, 2011
IFNL4 interferon lambda 4 (gene/pseudogene) :Recombinant IFNL4
is antiviral against HCV and coronaviruses Hamming
et al, 2013.
IGF2BP1 insulin-like growth factor 2 mRNA binding protein 1 enhances
viral translation Weinlich
et al, 2009
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2: knockdown
stimulates the release and/or egress of HCV particles without affecting
virus assembly Chatel-Chaix
et al, 2013
IGFBP6 insulin-like growth factor binding protein 6: siRNA knockdown
increases infection Li
et al, 2009
IGF2BP2 – insulin-like growth factor 2 mRNA binding protein
2: knockdown stimulates release and/or egress of HCV particles without
affecting viral assembly Chatel-Chaix
et al, 2013
IGLL1 immunoglobulin lambda-like polypeptide 1interacts
with NS5A protein De
Chassey et al, 2008
IGSF8 immunoglobulin superfamily, member 8: inhibits infection
via interaction with CD81 Rocha-Perugini
et al, 2008
IGSF11: immunoglobulin superfamily, member 11: siRNA knockdown
decreases infection Li
et al, 2009
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells,
kinase beta: interacts with the core protein Joo
et al, 2005
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells,
kinase gamma: The IKK complex is involved in the effects or pkr
on NFKB1 activation Bonnet
et al, 2006
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells,
kinase epsilon interacts with NS3 protein Otsuka
et al, 2005
IL1A interleukin 1, alpha: IL1A , EGF, and HGF suppress the antiviral
activity of interferons in primary monkey hepatic cells Takahara
et al, 1999
IL1B interleukin 1, beta: The virus acts as a ligand for TLR2
on human Kuppfer cells , which then secrete IL1B , TNF-alpha (TNF)
, and IL10 and up-regulate cell surface CD274 (PD-L1) Tu
et al, 2010.
IL2 interleukin 2: HCV E2 protein inhibits IL2 secretion via PRKCB
in peripheral blood mononuclear cells Petrovic
et al, 2011
IL4 interleukin 4 (B-cell growth factor 1): serum levels elevated
in infected patients Reiser
et al, 1997
IL4RA interleukin 4 receptor: polymorphism associates with viral
hepatitis Goncharova
et al, 2005
IL5 Interleukin 5 interleukin 5 (colony-stimulating factor, eosinophil):
IL4, IL5 and IL10 are secreted by Th2 cells (involved in activation
of B lymphocytes and in neutralising antibody production Kráslová
et al, 2003.
IL6 interleukin 6 (interferon, beta 2): The core protein activates
STAT3 in monocytes/macrophages/dendritic cells via an IL6 pathway
Tacke
et al, 2011
IL7R interleukin 7 receptor (CD127) : Reduced expression in CD4(+)
and CD8(+) T lymphocytes associated with viral persistence Golden-Mason
et al, 2006
IL10 interleukin 10: The virus acts as a ligand for TLR2 on human
Kuppfer cells , which then secrete IL1B , TNF-alpha (TNF) , and
IL10 and up-regulate cell surface CD274 : (PD-L1) Tu
et al, 2010.
IL11 interleukin 11: demonstrates beneficial effects in infected
patients with hepatic inflammation and advanced liver disease
IL12A interleukin 12A (natural killer cell stimulatory factor
1, cytotoxic lymphocyte maturation factor 1, p35) The E2 protein
nhibites IFN-gamma production by IL12 activated natural killer cells
Crotta
et al, 2010
IL12B interleukin 12B (natural killer cell stimulatory factor
2, cytotoxic lymphocyte maturation factor 2, p40): The E2 protein
nhibites IFN-gamma production by IL12 activated natural killer cells
Crotta
et al, 2010: Polymorphism affects infection Hegazy
et al, 2008
IL13 interleukin 13 Inreased secretion by T cells in infection
Inoue
et al, 2006
IL15 interleukin 15: produced by macrophages and various other
cells in response to environmental stimuli and infectious agents
Kirman
et al, 1998
IL16 interleukin 16: Polymorphism affects hepatitis infection
Kimball
et al, 2006 : attracts CD4+ cells to sites of inflammation and
plays a role in the interaction of dendritic cells, T cells and
B cells.
IL17A IL17B Alloantigen presentation by monocytes isolated from
HCV-infected patients results in impaired production of interleukin
17 by naive CD4(+) T cells in the presence of TLR ligands
Chung et al, 2010.
IL17RB interleukin 17 receptor B : siRNA knockdown increases infection
Li
et al, 2009
IL18 interleukin 18 (interferon-gamma-inducing factor) : Serum
levels increased in viral hepatitis Sharma
et al, 2009
IL23A interleukin 23, alpha subunit p19 increases in the numbers
of IFNG -producing, HCV-specific CD8+ cells in mice Matsui
et al, 2004
IL32 interleukin 32 involved in viral-associated liver inflammation/fibrosis:
without antiviral effects Moschen
et al, 2011
ILF2 interleukin enhancer binding factor 2, 45kD binds to core
protein Lee
et al, 2011
ILF3 interleukin enhancer binding factor 3, 90kDa involved in
viral RNA replication Isken
et al, 2007
ILVBL: ilvB (bacterial acetolactate synthase)-like: siRNA knockdown
decreases infection Li
et al, 2009
IMP4: IMP4, U3 small nucleolar ribonucleoprotein, homolog (yeast):
siRNA knockdown decreases infection Li
et al, 2009
IMPDH1IMP (inosine 5'-monophosphate) dehydrogenase 1 : siRNA knockdown
increases infection Li
et al, 2009
INF2 inverted formin, FH2 and WH2 domain containing C14orf73:
chromosome 14 open reading frame 73: siRNA knockdown decreases infection
Li
et al, 2009
INO80E INO80 complex subunit E (ex CCDC95) interacts with NS3
protein De
Chassey et al, 2008
INPPL1 – inositol polyphosphate phosphatase-like 1: The
HCV core protein, expressed in Huh7 and MDCK cells, disrupted apicobasal
polarity and decreased the expression of the polarity protein Dlg1
and the PI phosphatase INPPL1 Awad
et al, 2013
IQCB1 IQ motif containing B1: siRNA knockdown decreases infection
Li
et al, 2009
IRF5 – interferon regulatory factor 5: IRF1 and IRF5 control
interferon-independent signaling events leading to anti-HCV responses
Nandakumar
et al, 2013
IRF9 interferon regulatory factor 9: inhibits viral replication
Poat
et al , 2010
IRGM immunity-related GTPase family, M: siRNA knockdown impairs
Measles virus, Hepatitis C virusand human immunodeficiency virus-1-induced
autophagy and viral particle production Grégoire
et al, 2011
IRS1 insulin receptor substrate 1: infection in vitro triggers
endoplasmic reticulum stress and downregulates IRS1 and 2 via upregulation
of SOCS3 Ahmed
et al, 2014
ISG15 interferon-induced 15 kDa protein ISG15 ubiquitin-like modifier
promotes viral production in vitro Chen
et al, 2010 but influences HSV replication in both a positive
and negative manner Domingues
et al, 2015
ISLR immunoglobulin superfamily containing leucine-rich repeat
interacts with p7 protein Huang
et al, 2005
ITGA7: integrin, alpha 7 : siRNA knockdown decreases infection
Li
et al, 2009
ITGB1 integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated
antigen 1; alpha polypeptide) interacts with E2 protein De
Chassey et al, 2008
LARP1 – La ribonucleoprotein domain family, member 1: knockdown
stimulates release and/or egress of HCV particles without affecting
viral assembly Chatel-Chaix
et al, 2013
LCK lymphocyte-specific protein tyrosine kinase interacts with
NS5A protein MacDonald
et al, 2005
LRRC7 leucine rich repeat containing 7 interacts with NS3 protein
De
Chassey et al, 2008
LRRCC1 leucine rich repeat and coiled-coil domain containing 1
interacts with NS3 protein De
Chassey et al, 2008
LRRTM1 leucine rich repeat transmembrane neuronal 1 interacts
with CORE protein De
Chassey et al, 2008
LSM1 LSM1 homolog, U6 small nuclear RNA associated: LSM1-7 bind
to Translation/Replication Regulatory Signals in the HCV 5' and
3' untranslated regions. Scheller
et al, 2009
LSM2 LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LSM3 LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LSM7 LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LTA lymphotoxin alpha: TNF-a, TNF-ß (LTA) , TWEAK and LIGHT
promote HCV entry via NFKB mediated activation of myosin light chain
kinase (MYLK3) and disruption of tight junctions Fletcher
et al, 2016
LTBP4 latent transforming growth factor beta binding protein 4
interacts with CORE, NS3 De
Chassey et al, 2008
LTB lymphotoxin beta (TNF superfamily, member 3): Induced by NS5B
in Huh7 cells Simonin
et al, 2013
LTBR lymphotoxin beta receptor (TNFR superfamily, member 3) binds
to core protein Matsumoto
et al, 1997
LTC4S: leukotriene C4 synthase: siRNA knockdown decreases infection
Li
et al, 2009
LYN v-yes-1 Yamaguchi sarcoma viral related oncogene homolog interacts
with NS5A protein MacDonald
et al, 2005
LZTS2 leucine zipper, putative tumor suppressor 2 interacts with
NS3 protein De
Chassey et al, 2008
MAF v-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian):
binds to NS3 protein preventing nrf2 (NFE2L2) entry to the nucleus
Carvajal-Yepes
et al, 2011
MAGED1 melanoma antigen family D, 1 interacts with CORE and NS3
proteins De
Chassey et al, 2008
MAP2K1 mitogen-activated protein kinase kinase 1 (MEK1) Involved
in viral replication Gretton
et al, 2010
MAP2K5 mitogen-activated protein kinase kinase 5 (MEK5) : activated
hepatitis C non-enveloped capsid-like particles Katsarou
et al, 2011
MAP3K11 mitogen-activated protein kinase kinase kinase 11 (mixed
lineage kinase 3): NS5A inhibits MAP3K11 to block apoptosis Amako
et al, 2013
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase
3: binds to core protein Ngo
et al, 2013
MAP2K5 mitogen-activated protein kinase kinase 5: Expression suppresses
HCV infection Lee
et al, 2014.
MAP2K7 mitogen-activated protein kinase kinase 7: involved in
viral replication (siRNA study) Ng
et al, 2007
MAP4: microtubule-associated protein 4: siRNA knockdown decreases
infection Li
et al, 2009
MAPK1 mitogen-activated protein kinase 1 (ERK) Involved in the
neurotoxic effects of viral infection Paulino
et al, 2011 : siRNA knockdown decreases infection Li
et al, 2009
MAPK7 mitogen-activated protein kinase 7 interacts with NS3 protein
De
Chassey et al, 2008
MAPK8 mitogen-activated protein kinase 8 (JNK1) HCV infection
activates JNK via increased mitochondrial reactive oxygen species
production, resulting in decreased FoxO1 phosphorylation and nuclear
accumulation Deng
et al, 2011
MAPK9 mitogen-activated protein kinase 9: MAPK8 and 9 (JNK1 and
JNK2) restrict HCV replication Kim
et al, 2013
MAPK12 mitogen-activated protein kinase 12 interacts with NS5A
protein Randall
et al, 2007
MARK3: MAP/microtubule affinity-regulating kinase 3: siRNA knockdown
decreases infection Li
et al, 2009
MASP2 mannan-binding lectin serine peptidase 2 binds to E2 protein
Brown
et al, 2010
MAVS mitochondrial antiviral signaling protein cleaved by the
NS3-4A serine protease Meylan
et al, 2005
MBL2 mannose-binding lectin (protein C) 2, soluble binds to E2
protein Brown
et al, 2010
MGP matrix Gla protein interacts with NS5A protein Ahn
et al, 2004
MIR16-1 MicroRna 16-1: Increased miR-16 expression induced by
hepatitis C virus infection promotes liver fibrosis through downregulation
of hepatocyte growth factor and Smad7 Zhu
et al, 2015.
MIR21 – microRNA 21: HCV-induced miR-21 produces immune
evasion by targets MyD88 and IRAK1 Chen
et al, 2013.
MIR27A microRNA 27a: Inhibits viral replication in human hepatoma
cells Shirasaki
et al, 2013
MIR107 microrna 107: HCV-induced downregulation of MIR449A and
MIR107 regulate CCL2 expression by activation of the IL6-mediated
signaling cascade Sarma
et al, 2014
MIR130A microRNA 130a: inhibits HCV replication/production by
restoring host innate immune responses and/or downregulating pro-HCV
miR-122 Li
et al, 2014
MIR155 microRNA155: regulates interferon production in natural
killer cells via Tim-3 signalling in chronic hepatitis C virus infection
Cheng
et al, 2015.
MIR181C inhibits HCV replication by directly binding with HCV
E1 and NS5A sequences Mukherjee
et al, 2014
MIR196A1 microRNA 196a-1 : inhibits HCV expression in HCV replicon
cell lines (genotype 1b) and in J6/JFH1 (genotype 2a) HCV cell culture
system Hou
et al, 2010.
MIR194-1 MIR194-2 inhibits HCV entry by targeting CD81 receptor
Mekky
et al, 2015
MIR449A microRNA 449a: HCV-induced changes in MIR449A and MIR107
regulate CCL2 expression by activation of the IL6-mediated signaling
cascade Sarma
et al, 2014
MIR942 MicroRNA942: mediates Hepatitis C Virus-Induced Apoptosis
via Regulation of ISG12a Yang
et al, 2014.
Extracellular levels of miR-122, MIR34A
and to a lesser extent miR-16 (Renamed to GDE1 glycerophosphodiester
phosphodiesterase 1) increase following infection in vitro Cermelli
et al, 2011
MIR146A The impact of chronic hepatitis C infection on cholesterol
metabolism in PBMCs is associated with microRNA-146a expression.Sidorkiewicz
et al, 2016
MIRLET7B microRNA let-7b: Regulates viral replication Cheng
et al, 2012
MKNK1 MAP kinase interacting serine/threonine kinase 1: Facilitates
viral entry Kim
et al, 2013
MYLK3 myosin light chain kinase 3 TNF-a, LTA, TWEAK and LIGHT
promote HCV entry via NFKB mediated activation of myosin light chain
kinase (MYLK3) and disruption of tight junctions Fletcher
et al, 2016
MLLT1: myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog,
Drosophila); translocated to, 1: siRNA knockdown decreases infection
Li
et al, 2009
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog,
Drosophila); translocated to, 4: interacts with NS3 protein De
Chassey et al, 2008
MLXIPL: MLX interacting protein-like: siRNA knockdown decreases
infection Li
et al, 2009
MMP3 MMP3 expression decreased after core protein treatment and
increased in NS3/4A-stimulated macrophages Fan
et al, 2015
MMP14 matrix metallopeptidase 14 (membrane-inserted): Overexpression
in Huh7.5 cells suppressed cell entry of HCV pseudoparticles as
well as HCV infection Chang
et al, 2015.
NFE2 nuclear factor (erythroid-derived 2), 45kDa : interacts with
NS5A protein De
Chassey et al, 2008
NFE2L2 nuclear factor (erythroid-derived 2)-like 2 MAF binds to
NS3 protein preventing NFE2L2 nuclear entry Carvajal-Yepes
et al, 2011
NFKB1 nuclear factor of kappa light polypeptide gene enhancer
in B-cells 1: activated by NS2 Oem
et al, 2008
NFKB2 nuclear factor of kappa light polypeptide gene enhancer
in B-cells 2 (p49/p100): involved in viral replication (siRNA study)
Ng
et al, 2007
NFKBIA nuclear factor of kappa light polypeptide gene enhancer
in B-cells inhibitor, alpha: Inhibits CHUK, RELA and NFKB1 and interacts
with many other viral-related proteins NCBI
interactions
NLRP3 NLR family, pyrin domain containing 3:: HCV exploits the
NLRP3-inflammasome to activate SREBPs and host lipid metabolism
leading to liver disease pathogenesis McRae
et al, 2015
NMT1: N-myristoyltransferase 1: siRNA knockdown decreases infection
Li
et al, 2009
NOC4L: nucleolar complex associated 4 homolog (S. cerevisiae):
siRNA knockdown decreases infection Li
et al, 2009
NOL1: nucleolar protein 1, 120kDa: siRNA knockdown decreases infection
Li
et al, 2009
NOL5A: nucleolar protein 5A (56kDa with KKE/D repeat): siRNA knockdown
decreases infection Li
et al, 2009
NOL6: nucleolar protein family 6 (RNA-associated): siRNA knockdown
decreases infection Li
et al, 2009
NOP5 NOP58: nucleolar protein NOP5/NOP58: siRNA knockdown decreases
infection Li
et al, 2009
Nordihydroguaiaretic acid, a lipid lowering agent, reduces viral
replication and secretion,decreased sterol regulatory element binding
protein (SREBP) activation and enhancing expression of genes involved
in ß-oxidation Syed
and Siddiqui, 2011
NOS1AP: nitric oxide synthase 1 (neuronal) adaptor protein: siRNA
knockdown decreases infection Li
et al, 2009
NR1H3 Liver X receptor alpha: core protein enhances the binding
of LXRalpha/RXRalpha to LXR-response elements in the presence but
not the absence of PA28gamma Moriishi
et al, 2007
NR4A1 nuclear receptor subfamily 4, group A, member 1: (nurr77)
CORE, E1, E2, NS2, NS4A, NS5B De
Chassey et al, 2008
NT5C 5', 3'-nucleotidase, cytosolic: Viral NS3 interacts with
and inhibits cytosolic 5'(3')-deoxyribonucleotidase Fang
et al, 2013.
NUAK2 NUAK family, SNF1-like kinase, 2: (SNARK) involved in viral
replication (siRNA study) Ng
et al, 2007 : siRNA knockdown decreases infection Li
et al, 2009
PABPC1 poly(A) binding protein, cytoplasmic 1: stress granule
component distributed to the HCV production factory Ariumi
et al, 2011
PABPN1 : poly(A) binding protein, nuclear 1 interacts with CORE
protein De
Chassey et al, 2008
PACSIN1 protein kinase C and casein kinase substrate in neurons
1 : Expression suppresses HCV infection Lee
et al, 2014.
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1: siRNA knockdown
increases viral RNA and protein abundance in established replicon
cell lines Ishida
et al, 2007
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4 interacts with
CORE protein De
Chassey et al, 2008
PARK2 parkinson protein 2, E3 ubiquitin protein ligase (parkin):
HCV infection stimulates Parkin and PINK1 gene expression, induced
perinuclear mitochondrial clustering , and promoted mitochondrial
translocation of Parkin Kim
et al, 2013
PARP4 poly (ADP-ribose) polymerase family, member 4 interacts
with NS3 protein De
Chassey et al, 2008
PARP11 poly (ADP-ribose) polymerase family, member 11: poly (ADP-ribose)
polymerase family, member 11: siRNA knockdown decreases infection
Li
et al, 2009
PATL1 protein associated with topoisomerase II homolog 1 (yeast):
regulates viral translation Scheller
et al, 2009
PC – pyruvate carboxylase : Component of the viral replication
complex Park
et al, 2013 interacts with viral NS5A Yim
et al, 2013
PCBP2 poly(rC) binding protein 2 interacts with the viral genome
Fukushi
et al, 2001
PCYT2 phosphate cytidylyltransferase 2, ethanolamine interacts
with NS3 protein De
Chassey et al, 2008
PDCD1 programmed cell death 1: HCV core treatment of monoctytes
and macrophages from infected subjects at baseline increases PDCD1
expression that correlated with IL12 inhibition.Zhang
et al, 2011
PDCD6IP programmed cell death 6 interacting protein (Alix) knockdown
suppressees infectivity Ariumi
et al, 2011
PCSK9 proprotein convertase subtilisin/kexin type 9: Negatively
regulates viral replication Sved
et al, 2013
PDE4DIP phosphodiesterase 4D interacting protein (myomegalin)
interacts with NS3 protein De
Chassey et al, 2008
PDK1 pyruvate dehydrogenase kinase, isozyme 1: IFN-alpha does
not activate PRK2 (PKN2) or its upstream kinase PDK1 in infected
cells Kim
et al, 2009
PDK3 pyruvate dehydrogenase kinase 3 : HCV infection increases
c-Myc, HIF-1a, PDK1, and PDK3 levels in human liver: protein and
mRNA expression levels of PHGDH, PSAT1, and PSPHJung
et al, 2016.
PIK3C2B – phosphatidylinositol-4-phosphate 3-kinase, catalytic
subunit type 2 beta: knockdown represses viral full-genome replication
in human hepatocellular carcinoma cells Maehama
et al, 2013
PIK3C3 phosphoinositide-3-kinase, class 3 (vps34) complexes with
NS4B together with rab5 Su
et al, 2011
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
interacts with NS5A protein Street
et al, 2004
PIK4CA phosphatidylinositol 4-kinase, catalytic, alpha interacts
with NS5A protein Ahn
et al, 2004
PIN1 prolyl isomerase required for propagation Lim
et al, 2011
PINK1 PTEN induced putative kinase 1: HCV infection stimulates
Parkin and PINK1 gene expression Kim
et al, 2013
PITX1 paired-like homeodomain 1: interacts with NS5A protein
Ghosh et al, 2003
PLA1A phospholipase A1 member A: involved in Hepatitis C Virus
Assembly through NS2 Complex Formation Guo
et al, 2014.
PLA2G4C phospholipase A2, group IVC (cytosolic, calcium-independent):
involved in viral replication and assembly Xu
et al, 2012
PLB1 phospholipase B1 : siRNA knockdown decreases infection Li
et al, 2009
PLCG1 phospholipase C gamma 1: SYK interacts with NS5A which downregulates
SYK phosphorylation of PLCG1 Inubishi
et al, 2008
PLEKHA8 pleckstrin homology domain containing, family A (phosphoinositide
binding specific) member 8 (fapp2): depletion attenuated HCV infectivity
and impeded HCV RNA synthesis: Khan
e al, 2014
PLIN3 perilipin 3 : targets the NS5A-complexed RNA genome from
the replicon complex to the lipid droplet Ploen
et al, 2013.
PLK1 Polo like kinase phosphorylates NS5A Chen
et al, 2010 PLK1 Regulates interferon production by MAVS via
dissociation of MACS/TRAF3 Vitour
et al, 2009
Saturated (lauric, myristic, and palmitic) and Monounsaturated
(Oleic) fatty acids increase viral replication Kapadia
and Chisari, 2005 Malondialdehde, a lipid peroxidation product
generated by arachidonic acid inhibits viral replication an
effect reversed by Vitamin E Huang
et al, 2007
PPARD – peroxisome proliferator-activated receptor delta:
PPARD antagonists inhibit viral replication Ban
et al, 2013
PPARG peroxisome proliferator-activated receptor gamma activated
by NS5A Kim
et al, 2009
PPIA peptidylprolyl isomerase A (cyclophilin A) binds to NS5A
Waller
et al, 2010 : siRNA knockdown decreases infection Li
et al, 2009
PPIB peptidylprolyl isomerase B (cyclophilin B) interacts with
NS5B protein Watashi
et al, 2005
PPP1R13L protein phosphatase 1, regulatory (inhibitor) subunit
13 like interacts with NS5A protein De
Chassey et al, 2008
PPP2R1A: protein phosphatase 2 (formerly 2A), regulatory subunit
A , alpha isoform: siRNA knockdown decreases infection Li
et al, 2009
PPTC7: PTC7 protein phosphatase homolog (S. cerevisiae): siRNA
knockdown decreases infection Li
et al, 2009
PRKACA protein kinase, cAMP-dependent, catalytic, alpha interacts
with NS3 protein Borowski
et al, 1996
PRKRA protein kinase, interferon-inducible double stranded RNA
dependent activator: overexpression of the hepatitis C virus (HCV)
core protein inhibited the translation of a reporter mRNA harboring
the PRKRA 5' UTR Lai
et al, 2015
PRKRIP1: PRKR interacting protein 1 (IL11 inducible): siRNA knockdown
decreases infection Li
et al, 2009
RAB7L1 RAB7, member RAS oncogene family-like 1 mediator of HCV
clathrin-dependent endocytosis (siRNA study) Coller
et al, 2009
RAB10: RAB10, member RAS oncogene family: siRNA knockdown decreases
infection Li
et al, 2009
RAB11A: RAB11A, member RAS oncogene family: siRNA knockdown decreases
infection Li
et al, 2009
RAB14 member RAS oncogene family interacts with F protein Huang
et al, 2005
RAB18 – RAB18, member RAS oncogene family: Binds to NS5A
Salloum
et al, 2013
RAB32, member RAS oncogene family: required for the assembly of
HCV. Pham
et al, 2016
RABEP1 rabaptin, RAB GTPase binding effector protein 1 interacts
with NS3 protein De
Chassey et al, 2008
RABEPK Rab9 effector protein with kelch motifs : Rab9 effector
protein with kelch motifs: siRNA knockdown decreases infection Li
et al, 2009
RAC1: ras-related C3 botulinum toxin substrate 1 (rho family,
small GTP binding protein Rac1): siRNA knockdown decreases infection
Li
et al, 2009
RACGAP1 Rac GTPase activating protein : interacts with the viral
protein NS5B Wu
et al,2014
RAF1 v-raf-1 murine leukemia viral oncogene homolog 1 interacts
with NS5A protein Bürckstümmer
et al, 2006 : siRNA knockdown decreases infection Li
et al, 2009
IPO5 Importin 5 (RANBP5) interacts with NS5A protein Chung
et al, 2000
RARRES3 retinoic acid receptor responder (tazarotene induced)
3 (RIG1) responsible for the induction of IFN-ß and TRAIL
and apoptosis of primary human hepatocytes in response to HCV infection
Yang
et al, 2011.
RPA1 replication protein A1, 70kDa: NS5A and cellular replication
protein A functionally cooperate as a processivity factor to stimulate
HCV replication Mani
et al, 2015
RPAIN RPA interacting protein : siRNA knockdown decreases infection
Li
et al, 2009
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member
1 interacts with F protein Huang
et al, 2005
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen
activator inhibitor type 1- pai-1), member 1 binds to internal ribosomal
entry site.Lu
et al, 2004
SERPINF2 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin,
pigment epithelium derived factor), member 2 interacts with NS3
protein Drouet
et al, 1999
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member
1 interacts with NS3 protein Drouet
et al, 1999
SIK2 salt-inducible kinase 2: siRNA knockdown decreases infection
Li
et al, 2009
SLC6A8: solute carrier family 6 (neurotransmitter transporter,
creatine), member 8 : siRNA knockdown decreases infection Li
et al, 2009
SLC6A12 solute carrier family 6 (neurotransmitter transporter,
betaine/GABA), member 12 Plays a role in viral entry Satoh
et al, 2011
SLC10A1 solute carrier family 10 member 1 ( sodium/bile acid cotransporter):
mediates HCV infection of hepatocytes and is relevant for cell-to-cell
transmission
SLC11A1: solute carrier family 11 (proton-coupled divalent metal
ion transporters), member 1 : siRNA knockdown decreases infection
Li
et al, 2009
SLC12A4 solute carrier family 12 (potassium/chloride transporters)involved
in viral replication (siRNA study) Ng
et al, 2007
SLC12A5 solute carrier family 12 (potassium-chloride transporter)
involved in viral replication (siRNA study) Ng
et al, 2007
SLC22A7 solute carrier family 22 (organic anion transporter),
member 7 interacts with CORE protein Kang
et al, 2005
SLC24A6 solute carrier family 24 (sodium/potassium/calcium exchanger),
member 6: siRNA knockdown decreases infection Li
et al, 2009
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine
nucleotide translocator), member 5 interacts with core protein Tripathi
et al, 2010
SLC31A2 solute carrier family 31 (copper transporters), member
2 interacts with CORE protein De
Chassey et al, 2008
SLCO1B7 solute carrier organic anion transporter family, member
1B7 (non-functional)
SMAD4 SMAD family member 4: Expression increased by the core protein
and involved in viral regulation of hepcidin Foka
et al, 2014
SMAD5: SMAD family member 5: siRNA knockdown decreases infection
Li
et al, 2009
SMAD6: SMAD family member 6: siRNA knockdown decreases infection
Li
et al, 2009
SMAD7 SMAD family member 7 :Increased miR-16 expression induced
by hepatitis C virus infection promotes liver fibrosis through downregulation
of hepatocyte growth factor and Smad7 Zhu
et al, 2015.
SMARCD3: SWI/SNF related, matrix associated, actin dependent regulator
of chromatin, subfamily d, member 3: siRNA knockdown decreases infection
Li
et al, 2009
SMEK2 SMEK homolog 2, suppressor of mek1 (Dictyostelium) interacts
with E2 protein De
Chassey et al, 2008
SMURF1: SMAD specific E3 ubiquitin protein ligase 1 : siRNA knockdown
decreases infection Li
et al, 2009
SOCS1 suppressor of cytokine signaling 1: expression increased
by the core protein in monocytes and macrophages Zhang
et al, 2011
SOCS3 suppressor of cytokine signaling 3 suppresses viral replication
via mtor Shao
et al, 2010
SORBS2 sorbin and SH3 domain containing 2 interacts with NS5A
protein De
Chassey et al, 2008
SORBS3 sorbin and SH3 domain containing 3 (viexin) interacts with
NS5A protein De
Chassey et al, 2008
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
hepatic expression increased in response to HCV Infection in the
Chimeric SCID-beige/Alb-uPA Mouse Walters
et al, 2006
SOS1 son of sevenless homolog 1 (Drosophila) : NS5A may compete
with Sos for binding to Grb2 Tan
et al, 1999 (GRB2 binds to SOS1 and SOS2)
SOS2 son of sevenless homolog 2 (Drosophila): NS5A binds to grb2
may compete with Sos for binding to Grb2 Tan
et al, 1999
SPCS1 signal peptidase complex subunit 1 homolog (S. cerevisiae)
: siRNA knockdown decreases infection Li
et al, 2009
SPCS2 signal peptidase complex subunit 2 homolog (S. cerevisiae)
: siRNA knockdown decreases infection Li
et al, 2009
SPCS3 signal peptidase complex subunit 3 homolog (S. cerevisiae)
: siRNA knockdown decreases infection Li
et al, 2009
SPDEF: SAM pointed domain containing ets transcription factor:
siRNA knockdown decreases infection Li
et al, 2009
SPOCK3 sparc/osteonectin, cwcv and kazal-like domains proteoglycan
(testican) 3 interacts with NS3 protein De
Chassey et al, 2008
SPICE1 spindle and centriole associated protein 1 (ex CCDC52)
interacts with NS3 protein De
Chassey et al, 2008
SPON1 spondin 1, extracellular matrix protein interacts with NS3
protein De
Chassey et al, 2008
SPPL2A peptidase-like 2A part of a signal peptidase that processes
the hepatitis C virus core protein Weihofen
et al, 2002
SPPL2B signal peptide peptidase-like 2B part of a signal peptidase
that processes the hepatitis C virus core protein Weihofen
et al, 2002
SPPL3 part of a signal peptidase that processes the hepatitis
C virus core protein Weihofen
et al, 2002
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
required for complex formation between viral proteins NS5A and NS5B.Pfannkuche
et al, 2011
SREBF2 sterol regulatory element binding transcription factor
2: Regulates many of the sterol pathway enzymes involved in viral
replication Owens
et al, 2010
SRCAP Snf2-related CREBBP activator protein interacts with NS5A
protein Ghosh
et al, 2000
SRFBP1: serum response factor binding protein 1: siRNA knockdown
decreases infection Li
et al, 2009
SPCS1 signal peptidase complex subunit 1 homolog: Participates
in viral assembly via interaction with E2 and NS2 proteins Suzuki
et al, 2013
SQSTM1 (p62) sequestosome 1: strong accumulation of p62 protein
levels in the monocytes cultured in the presence of HCV-positive
serum Granato
et al, 2015
SRI sorcin : siRNA knockdown decreases infection Li
et al, 2009
SRPX2 sushi-repeat containing protein, X-linked 2 interacts with
NS3 protein De
Chassey et al, 2008
SRRM2 serine/arginine repetitive matrix 2 : siRNA knockdown decreases
infection Li
et al, 2009
SRRT Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6: (ARS2)
interacts with NS3 protein De
Chassey et al, 2008
SSR4 signal sequence receptor, delta (translocon-associated protein
delta) interacts with p7 protein Huang
et al, 2005
SSX2IP synovial sarcoma, X breakpoint 2 interacting protein interacts
with NS3 protein De
Chassey et al, 2008
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 interacts
with F protein Huang
et al, 2005
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 :
serum levels of ST6Gal I , a BACE1 substrate, in hepatitis C patients
was correlates with hepatic inflammation Kitazume
et al, 2009.
STAT1 signal transducer and activator of transcription 1, 91kDa:
interacts with CORE protein Lin
et al, 2005
STAT2 signal transducer and activator of transcription 2, 113kDa:
higher expression levels of STAT1, STAT2 and STAT5 are seen in liver
tissue from HCV patients Bautista
et al, 2007
STAT3 signal transducer and activator of transcription 3 (acute-phase
response factor) : Interacts with CORE and NS3 proteins De
Chassey et al, 2008 : siRNA knockdown decreases infection Li
et al, 2009
STAT5A signal transducer and activator of transcription 5A: higher
expression levels of STAT1, STAT2 and STAT5 are seen in liver tissue
from HCV patients Bautista
et al, 2007
STAU1 staufen, RNA binding protein, homolog 1 (Drosophila) mediator
of HCV clathrin-dependent endocytosis (siRNA study) Coller
et al, 2009
STIM2 stromal interaction molecule 2 : siRNA knockdown decreases
infection Li
et al, 2009
STRBP spermatid perinuclear RNA binding protein binds to the viral
p7 protein Huang
et al, 2005
STMN2: stathmin-like 2: siRNA knockdown decreases infection Li
et al, 2009
STOM stomatin: Interacts with the viral RNA polymerase Kim
et al, 2014
STRAP serine/threonine kinase receptor associated protein binds
to internal ribosomal entry site.Lu
et al, 2004
STRBP spermatid perinuclear RNA binding protein interacts with
p7 protein Huang
et al, 2005
STX2: syntaxin 2: siRNA knockdown decreases infection Li
et al, 2009
SUMO1 small ubiquitin-like modifier 1: depletion prevents lipid
droplet accumulation and HCV replication Akil
et al, 2015.
SURF1: surfeit 1: siRNA knockdown decreases infection Li
et al, 2009
SUV420H1: suppressor of variegation 4-20 homolog 1 (Drosophila):
siRNA knockdown decreases infection Li
et al, 2009
SUZ12: suppressor of zeste 12 homolog (Drosophila) : siRNA knockdown
decreases infection Li
et al, 2009
SVEP1 sushi, von Willebrand factor type A, EGF and pentraxin domain
containing 1 interacts with NS3 protein De
Chassey et al, 2008
SYK spleen tyrosine kinase interacts with NS5A which downregulates
SYK phosphorylation of PLCG1 Inubishi
et al, 2008
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
enhances ires function Park
et al, 2011
SYNE1 spectrin repeat containing, nuclear envelope 1 interacts
with NS3 protein De
Chassey et al, 2008
TICAM1 toll-like receptor adaptor molecule 1 (TRIF) interacts
with NS3 protein Ferreon
et al, 2005
TJP1 tight junction protein 1: involved in the early steps of
HCV infection Park
et al, 2013
TLR2 toll receptor recognises NS3 Beauvillain
et al, 2010 The virus acts as a ligand for TLR2 on human Kuppfer
cells , which then secrete interleukin Interleukin-1beta (IL1B)
, TNF-alpha (TNF) , and IL10 and up-regulate cell surface CD274
: (PD-L1) Tu
et al, 2010.
TNF The virus acts as a ligand for TLR2 on human Kuppfer cells
, which then secrete interleukin IL1B , TNF-alpha (TNF) , and IL10
and up-regulate cell surface CD274 : (PD-L1) Tu
et al, 2010.
TNFR1 tumor necrosis factor receptor superfamily, member 1A :Core
protein associates with a TNF-R1-TRADD-TRAF2 signalling complex
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
interacts with CORE protein Zhu
et al, 2001
TNFRSF1B tumor necrosis factor receptor superfamily member 1B:
the viral -induced endothelial inflammatory response depends on
the functional expression of TNFRSF1B Pircher
et al, 2014
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a
(DR4) : The virus sensitizes host cells to TRAIL-induced apoptosis
by up-regulating TRAIL receptors, death receptor 4 (DR4) and death
receptor 5 (TNFRSF10B) Deng
et al, 2012.
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
:see Deng
et al, 2012
TNFRSF18: tumor necrosis factor receptor superfamily, member 18
: siRNA knockdown increases infection Li
et al, 2009
TNFRSF21 – tumor necrosis factor receptor superfamily, member
21: Component of the viral replication complex Park
et al, 2013
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
( TRAIL) : Donregulated by infection in hepatic natural killer cells
Varchetta
et al, 2012
TNFSF12 tumor necrosis factor superfamily member 12 (TWEAK): TNF-a,
TNF-ß (LTA) , TWEAK and LIGHT promote HCV entry via NFKB mediated
activation of myosin light chain kinase (MYLK3) and disruption of
tight junctions Fletcher
et al, 2016
TNFSF14 tumor necrosis factor superfamily member 14 (LIGHT):TNF-a,
LTA, TWEAK and LIGHT promote HCV entry via NFKB mediated activation
of myosin light chain kinase (MYLK3) and disruption of tight junctions
Fletcher
et al, 2016
TNK1 tyrosine kinase, non-receptor, 1 : Plays a role in the interferon
antiviral response: TNK1 abundance is inversely correlated to viral
replication efficiency Ooi
et al, 2014
TNRC6A – trinucleotide repeat containing 6A :Ethanol increases
HCV replication via upregulation of TNRC6A and HSP90 in human hepatoma
cells Bukong
et al, 2012
TOP1: topoisomerase (DNA) I: siRNA knockdown decreases infection
Li
et al, 2009
TP73 tumor protein p73 interacts with CORE protein Alisi
et al, 2003
TPM4: tropomyosin 4: siRNA knockdown decreases infection Li
et al, 2009
TRADD TNFRSF1A-associated via death domain Core protein associates
with a TNF-R1-TRADD-TRAF2 signalling complex
TRAF2 TNF receptor-associated factor 2: interacts with NS5A protein
Park
et al,2002
TRAF3 TNF receptor-associated factor 3: PLK1 Regulates interferon
production by MAVS via dissociation of MACS/TRAF3 Vitour
et al, 2009
TRAF6 TNF receptor-associated factor 6 :dominant negative TRAF2
or TRAF6 significantly block NFKB1 pathway activation by the core
protein Yoshida
et al, 2001
TRAF3IP1 binds to internal ribosomal entry site.Lu
et al, 2004
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation
protein, beta polypeptide interacts with CORE protein Aoki
et al, 2000
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation
protein, epsilon polypeptide interacts with the core protein , releasing
BAX, activating the mitochondrial apoptosis programme (activation
of VDAC1 and release of mitochondrial cytochrome C (CYCS) ) Lee
et al, 2007 Plays an important role in antiviral MAVS/RIG-1
signalling (RNA viruses) Liu
et al, 2012
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation
protein, zeta polypeptide interacts with CORE protein Aoki
et al, 2000
YY1 transcription factor interacts with CORE protein Mai
et al, 2006
Gene Expression Profiling Indicates the Roles of Host Oxidative
Stress, Apoptosis, Lipid Metabolism, and Intracellular Transport Genes
in the Replication of Hepatitis C Virus Blackham
et al, 2010
Genes modifying replication or secretion (siRNA study ) ABLIM3
CYP1A1 DDX3X RAB27A RAB27B RAB33B RAB40B TXNIP
Proteomic Analysis of Hepatitis C Virus (HCV) Core Protein
Transfection and Host Regulator PA28gamma Knockout in HCV Pathogenesis:
A Network-Based Study.Tripathi
et al, 2012