These maps, etched out by numerous Alzheimer's disease susceptibility gene candidates are generated by Kegg pathways from the Kanehisa laboratories with thanks and are subject to their copyright conditions: Genes are enhanced by

Pathway Search Result YELLOW genes have been associated with Alzheimer's disease: Red componds are among those relevant to Alzheimer's disease. For a previous version, including Alzheimer's disease susceptibility genes also related to the herpes simplex life cycle, see this page

Pathway Search Result

Cholesterol and lipoproteins pathway APP is included as an honorary lipoprotein receptor for these reasons: It binds to APOE and cholesterol, and to LRP1. As with other lipoprotein receptors it is capped on the extracellular side by the lipoprotein receptor accessory protein, LRPAP1. Other lipoprotein receptors are also cleaved by gamma-secretase, and share intracellular domain binding partner's (Fe65 proteins and MAPK8IP1).Ref NB Alzheimer's genes are coded red in this figure

Following object(s) was/were not found Lipoprotein related: APOC1 APOC2 APOC4 APOD LPA LRP1B LRP8 LRPAP1 VLDLR ....................... ACAN ADAM12 ADAM9 AGBL4 AGER AHSG ALB ANGPT4 ANK3 APBA1 ARID1B ATF7 ATP8A1 ATXN1 BAT1 BCAM BCHE BIN1 BLMH C10orf112 C11orf30 C12orf41 cpd:C13391 cpd:C15610red C1orf49 C21orf55 C21orf63 C6ORF155 CALHM1 CAND1 CDC2 CDKN2BAS CECR2 CELF2 CETP CHD4 CHRFAM7A CLSTN2 CNTN5 COL25A1 CRP CTNND2 CUGBP2 DAB1 DCHS2 DEFB122 DFNB31 DISC1 DNMBP DOPEY2 DSC1 DYRK1A EBF3 ECE1 ELAVL4 ENTPD7 ESR2 FAM113B FAM63A FMMD4A FRMD6 FTO cpd:C16046 GBP2 GOLM1 GRN HBG2 hCG2039140 HFE HLA-A2 HNT HPCAL1 IREB2 KCDT12 KCNH7 KIF18B KLF5 LOC388458 LOC439999 LOC729993 LPAR5 LRRTM3 LSM14A MAL2 MCM3AP MCPH1 MEF2A MMEL2 MPHOSPH1 MS4A4A MS4A4E MS4A6A MSRA MT-COI MT-DLOOP MT-haplo MT-L2 MT-RNR1 NCAPD2 NEDD9 NGB NINJ2 NP NQO1 NR1H2 NR3A ODZ3 OPCML OPRS1 PAX2 PCDH11X PCGF5 PCMTD1 PDLIM5 PGBD1 PKP2P1 POU2F1 PPM1H PPP1R11 PRND PRSS7 PRUNE2 RALGPS2 RCAN1 RFTN1 RGSL2 S100B SAMSN1 SASH1 SCN2A SEPT3 SERPINA3 SH3PXD2A SHISA9 SORCS1 SORCS2 SORCS3 SORL1 STH SYN3 TAPBPL TARDBP TET1 TFCP2 THEM5 TMEM63C TNK1 TRIM15 TRPC4AP TTLL7 TTR UBD VSNL1 WWC1 ZNF155 ZNF224 ZNF225

hsa01100 Metabolic pathways - Homo sapiens (human) (80) (No pathway available) 

cpd:C00018 Pyridoxal phosphate
cpd:C00019 S-Adenosyl-L-methionine
cpd:C00025 L-Glutamate
cpd:C00031 D-Glucose
cpd:C00051 Glutathione
cpd:C00072 Ascorbate
cpd:C00078 L-Tryptophan
cpd:C00155 L-Homocysteine
cpd:C00187 Cholesterol
cpd:C00250 Pyridoxal
cpd:C00253 Nicotinate
cpd:C00376 Retinal
cpd:C00378 Thiamine
cpd:C00422 Triacylglycerol
cpd:C00473 Retinol
cpd:C00504 Folate
cpd:C00534 Pyridoxamine
cpd:C00535 Testosterone
cpd:C00951 Estradiol-17beta
cpd:C01717 4-Hydroxy-2-quinolinecarboxylic acid
cpd:C02094 beta-Carotene
cpd:C02477 alpha-Tocopherol
cpd:C03722 Quinolinate
cpd:C05441 Vitamin D2
cpd:C05443 Vitamin D3
cpd:C06427 (9Z,12Z,15Z)-Octadecatrienoic acid
hsa:27034 ACAD8; acyl-CoA dehydrogenase family, member 8
hsa:10554 AGPAT1; 1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha) (EC:2.3.1.51)
hsa:5832 ALDH18A1; aldehyde dehydrogenase 18 family, member A1 (EC:1.2.1.41 2.7.2.11)
hsa:217 ALDH2; aldehyde dehydrogenase 2 family (mitochondrial) (EC:1.2.1.3)
hsa:411 ARSB; arylsulfatase B (EC:3.1.6.12)
hsa:4508 ATP6; ATP synthase F0 subunit 6
hsa:4509 ATP8; ATP synthase F0 subunit 8
hsa:875 CBS; cystathionine-beta-synthase (EC:4.2.1.22)
hsa:1312 COMT; catechol-O-methyltransferase (EC:2.1.1.6)
hsa:4512 COX1; cytochrome c oxidase subunit I
hsa:1352 COX10; COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase (yeast) (EC:2.5.1.-)
hsa:1355 COX15; COX15 homolog, cytochrome c oxidase assembly protein (yeast)
hsa:4513 COX2; cytochrome c oxidase subunit II
hsa:4514 COX3; cytochrome c oxidase III
hsa:1588 CYP19A1; cytochrome P450, family 19, subfamily A, polypeptide 1 (EC:1.14.14.1)
hsa:4519 CYTB; cytochrome b
hsa:1621 DBH; dopamine beta-hydroxylase (dopamine beta-monooxygenase) (EC:1.14.17.1)
hsa:1718 DHCR24; 24-dehydrocholesterol reductase (EC:1.3.1.72)
hsa:1738 DLD; dihydrolipoamide dehydrogenase (EC:1.8.1.4)
hsa:1743 DLST; dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) (EC:2.3.1.61)
hsa:2224 FDPS; farnesyl diphosphate synthase (EC:2.5.1.1 2.5.1.10)
hsa:2597 GAPDH; glyceraldehyde-3-phosphate dehydrogenase (EC:1.2.1.12)
hsa:26330 GAPDHS; glyceraldehyde-3-phosphate dehydrogenase, spermatogenic (EC:1.2.1.12)
hsa:3156 HMGCR; 3-hydroxy-3-methylglutaryl-CoA reductase (EC:1.1.1.34)
hsa:3158 HMGCS2; 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) (EC:2.3.3.10)
hsa:3290 HSD11B1; hydroxysteroid (11-beta) dehydrogenase 1 (EC:1.1.1.146)
hsa:3990 LIPC; lipase, hepatic (EC:3.1.1.3)
hsa:4128 MAOA; monoamine oxidase A (EC:1.4.3.4)
hsa:25902 MTHFD1L; methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like (EC:6.3.4.3)
hsa:4524 MTHFR; methylenetetrahydrofolate reductase (NAD(P)H) (EC:1.5.1.20)
hsa:4548 MTR; 5-methyltetrahydrofolate-homocysteine methyltransferase (EC:2.1.1.13)
MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase belongs here 
hsa:10 NAT2; N-acetyltransferase 2 (arylamine N-acetyltransferase) (EC:2.3.1.5)
hsa:4535 ND1; NADH dehydrogenase, subunit 1 (complex I)
hsa:4536 ND2; MTND2
hsa:4537 ND3; NADH dehydrogenase, subunit 3 (complex I)
hsa:4538 ND4; NADH dehydrogenase, subunit 4 (complex I)
hsa:4539 ND4L; NADH dehydrogenase, subunit 4L (complex I)
hsa:4540 ND5; NADH dehydrogenase, subunit 5 (complex I)
hsa:4541 ND6; NADH dehydrogenase, subunit 6 (complex I)
hsa:349565 NMNAT3; nicotinamide nucleotide adenylyltransferase 3 (EC:2.7.7.1 2.7.7.18)
hsa:4842 NOS1; nitric oxide synthase 1 (neuronal) (EC:1.14.13.39)
hsa:4843 NOS2; nitric oxide synthase 2, inducible (EC:1.14.13.39)
hsa:4846 NOS3; nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39)
hsa:5009 OTC; ornithine carbamoyltransferase (EC:2.1.3.3)
hsa:5105 PCK1; phosphoenolpyruvate carboxykinase 1 (soluble) (EC:4.1.1.32)
hsa:50487 PLA2G3; phospholipase A2, group III (EC:3.1.1.4)
hsa:5409 PNMT; phenylethanolamine N-methyltransferase (EC:2.1.1.28)
hsa:5444 PON1; paraoxonase 1 (EC:3.1.1.2 3.1.8.1 3.1.1.81)
hsa:5445 PON2; paraoxonase 2 (EC:3.1.1.2 3.1.1.81)
hsa:5446 PON3; paraoxonase 3 (EC:3.1.1.2 3.1.8.1 3.1.1.81)
hsa:5743 PTGS2; prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1)
hsa:8879 SGPL1; sphingosine-1-phosphate lyase 1 (EC:4.1.2.27)
hsa:66008 TRAK2; trafficking protein, kinesin binding 2
hsa:64409 WBSCR17; Williams-Beuren syndrome chromosome region 17 (EC:2.4.1.41)

hsa05010 Alzheimer's disease - Homo sapiens (human) (32)



hsa:102 ADAM10; ADAM metallopeptidase domain 10 (EC:3.4.24.81)
hsa:322 APBB1; amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
hsa:51107 APH1A; anterior pharynx defective 1 homolog A (C. elegans)
hsa:348 APOE; apolipoprotein E
hsa:351 APP; amyloid beta (A4) precursor protein
hsa:4508 ATP6; ATP synthase F0 subunit 6
hsa:4509 ATP8; ATP synthase F0 subunit 8
hsa:23621 BACE1; beta-site APP-cleaving enzyme 1 (EC:3.4.23.46)
hsa:25825 BACE2; beta-site APP-cleaving enzyme 2 (EC:3.4.23.45)
hsa:1020 CDK5; cyclin-dependent kinase 5 (EC:2.7.11.22)
hsa:8851 CDK5R1; cyclin-dependent kinase 5, regulatory subunit 1 (p35)
hsa:4512 COX1; cytochrome c oxidase subunit I
hsa:4513 COX2; cytochrome c oxidase subunit II
hsa:4514 COX3; cytochrome c oxidase III
hsa:4519 CYTB; cytochrome b
hsa:355 FAS; Fas (TNF receptor superfamily, member 6)
hsa:2597 GAPDH; glyceraldehyde-3-phosphate dehydrogenase (EC:1.2.1.12)
hsa:2904 GRIN2B; glutamate receptor, ionotropic, N-methyl D-aspartate 2B
hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26)
hsa:3416 IDE; insulin-degrading enzyme (EC:3.4.24.56)
hsa:3553 IL1B; interleukin 1, beta
hsa:4023 LPL; lipoprotein lipase (EC:3.1.1.34)
hsa:4035 LRP1; low density lipoprotein receptor-related protein 1
hsa:4137 MAPT; microtubule-associated protein tau
hsa:4311 MME; membrane metallo-endopeptidase (EC:3.4.24.11)
hsa:23385 NCSTN; nicastrin
hsa:4842 NOS1; nitric oxide synthase 1 (neuronal) (EC:1.14.13.39)
hsa:5663 PSEN1; presenilin 1 (EC:3.4.23.-)
hsa:5664 PSEN2; presenilin 2 (Alzheimer disease 4)
hsa:55851 PSENEN; presenilin enhancer 2 homolog (C. elegans)
hsa:6622 SNCA; synuclein, alpha (non A4 component of amyloid precursor)
hsa:7124 TNF; tumor necrosis factor
APH1B APBB2 and APBB3 also belong here
hsa05200 Pathways in cancer - Homo sapiens (human) (27)



cpd:C00187 Cholesterol
cpd:C00535 Testosterone
cpd:C00951 Estradiol-17beta
hsa:367 AR; androgen receptor
hsa:613 BCR; breakpoint cluster region (EC:2.7.11.1)
hsa:29119 CTNNA3; catenin (cadherin-associated protein), alpha 3
hsa:1612 DAPK1; death-associated protein kinase 1 (EC:2.7.11.1)
hsa:355 FAS; Fas (TNF receptor superfamily, member 6)
hsa:2246 FGF1; fibroblast growth factor 1 (acidic)
hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26)
hsa:2950 GSTP1; glutathione S-transferase pi 1 (EC:2.5.1.18)
hsa:3479 IGF1; insulin-like growth factor 1 (somatomedin C)
hsa:3569 IL6; interleukin 6 (interferon, beta 2)
hsa:3576 IL8; interleukin 8
hsa:4312 MMP1; matrix metallopeptidase 1 (interstitial collagenase) (EC:3.4.24.7)
hsa:4843 NOS2; nitric oxide synthase 2, inducible (EC:1.14.13.39)
hsa:4914 NTRK1; neurotrophic tyrosine kinase, receptor, type 1 (EC:2.7.10.1)
hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
hsa:5468 PPARG; peroxisome proliferator-activated receptor gamma
hsa:5743 PTGS2; prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1)
hsa:861 RUNX1; runt-related transcription factor 1
hsa:6256 RXRA; retinoid X receptor, alpha
hsa:6655 SOS2; son of sevenless homolog 2 (Drosophila)
hsa:7040 TGFB1; transforming growth factor, beta 1
hsa:7157 TP53; tumor protein p53
hsa:7186 TRAF2; TNF receptor-associated factor 2
hsa:7422 VEGFA; vascular endothelial growth factor A

hsa04977 Vitamin digestion and absorption - Homo sapiens (human) (22)



cpd:C00018 Pyridoxal phosphate
cpd:C00072 Ascorbate
cpd:C00162 Fatty acid
cpd:C00187 Cholesterol
cpd:C00250 Pyridoxal
cpd:C00376 Retinal
cpd:C00378 Thiamine
cpd:C00422 Triacylglycerol
cpd:C00473 Retinol
cpd:C00504 Folate
cpd:C00534 Pyridoxamine
cpd:C02075 Retinyl ester
cpd:C02094 beta-Carotene
cpd:C02477 alpha-Tocopherol
cpd:C02530 Cholesterol ester
cpd:C05377 Menadione
cpd:C05443 Vitamin D3
cpd:C05776 Vitamin B12
hsa:335 APOA1; apolipoprotein A-I
hsa:337 APOA4; apolipoprotein A-IV
hsa:8029 CUBN; cubilin (intrinsic factor-cobalamin receptor)
hsa:9227 LRAT; lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase) (EC:2.3.1.135)

hsa05323 Rheumatoid arthritis - Homo sapiens (human) (19)



cpd:C05443 Vitamin D3
hsa:6347 CCL2; chemokine (C-C motif) ligand 2
hsa:6348 CCL3; chemokine (C-C motif) ligand 3
hsa:942 CD86; CD86 molecule
hsa:1435 CSF1; colony stimulating factor 1 (macrophage) (EC:2.7.10.1)
hsa:3123 HLA-DRB1; major histocompatibility complex, class II, DR beta 1
hsa:3383 ICAM1; intercellular adhesion molecule 1
hsa:3606 IL18; interleukin 18 (interferon-gamma-inducing factor)
hsa:3552 IL1A; interleukin 1, alpha
hsa:3553 IL1B; interleukin 1, beta
hsa:3569 IL6; interleukin 6 (interferon, beta 2)
hsa:3576 IL8; interleukin 8
hsa:4312 MMP1; matrix metallopeptidase 1 (interstitial collagenase) (EC:3.4.24.7)
hsa:4314 MMP3; matrix metallopeptidase 3 (stromelysin 1, progelatinase) (EC:3.4.24.17)
hsa:7040 TGFB1; transforming growth factor, beta 1
hsa:7097 TLR2; toll-like receptor 2
hsa:7099 TLR4; toll-like receptor 4
hsa:7124 TNF; tumor necrosis factor
hsa:7422 VEGFA; vascular endothelial growth factor A

hsa04010 MAPK signaling pathway - Homo sapiens (human) (18)



hsa:627 BDNF; brain-derived neurotrophic factor
hsa:783 CACNB2; calcium channel, voltage-dependent, beta 2 subunit
hsa:929 CD14; CD14 molecule
hsa:355 FAS; Fas (TNF receptor superfamily, member 6)
hsa:2246 FGF1; fibroblast growth factor 1 (acidic)
hsa:3304 HSPA1B; heat shock 70kDa protein 1B
hsa:3552 IL1A; interleukin 1, alpha
hsa:3553 IL1B; interleukin 1, beta
hsa:9479 MAPK8IP1; mitogen-activated protein kinase 8 interacting protein 1
hsa:4137 MAPT; microtubule-associated protein tau
hsa:4914 NTRK1; neurotrophic tyrosine kinase, receptor, type 1 (EC:2.7.10.1)
hsa:4915 NTRK2; neurotrophic tyrosine kinase, receptor, type 2 (EC:2.7.10.1)
hsa:50487 PLA2G3; phospholipase A2, group III (EC:3.1.1.4)
hsa:6655 SOS2; son of sevenless homolog 2 (Drosophila)
hsa:7040 TGFB1; transforming growth factor, beta 1
hsa:7124 TNF; tumor necrosis factor
hsa:7157 TP53; tumor protein p53
hsa:7186 TRAF2; TNF receptor-associated factor 2

hsa05012 Parkinson's disease - Homo sapiens (human) (17)



hsa:4508 ATP6; ATP synthase F0 subunit 6
hsa:4509 ATP8; ATP synthase F0 subunit 8
hsa:4512 COX1; cytochrome c oxidase subunit I
hsa:4513 COX2; cytochrome c oxidase subunit II
hsa:4514 COX3; cytochrome c oxidase III
hsa:4519 CYTB; cytochrome b
hsa:27429 HTRA2; HtrA serine peptidase 2 (EC:3.4.21.108)
hsa:120892 LRRK2; leucine-rich repeat kinase 2 (EC:2.7.11.1)
hsa:4535 ND1; NADH dehydrogenase, subunit 1 (complex I)
hsa:4536 ND2; MTND2
hsa:4537 ND3; NADH dehydrogenase, subunit 3 (complex I)
hsa:4538 ND4; NADH dehydrogenase, subunit 4 (complex I)
hsa:4539 ND4L; NADH dehydrogenase, subunit 4L (complex I)
hsa:4540 ND5; NADH dehydrogenase, subunit 5 (complex I)
hsa:4541 ND6; NADH dehydrogenase, subunit 6 (complex I)
hsa:6622 SNCA; synuclein, alpha (non A4 component of amyloid precursor)
hsa:7345 UCHL1; ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) (EC:3.4.19.12)

hsa05152 Tuberculosis - Homo sapiens (human) (17)



hsa:929 CD14; CD14 molecule
hsa:1378 CR1; complement component (3b/4b) receptor 1 (Knops blood group)
hsa:1509 CTSD; cathepsin D (EC:3.4.23.5)
hsa:1520 CTSS; cathepsin S (EC:3.4.22.27)
hsa:2207 FCER1G; Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
hsa:3123 HLA-DRB1; major histocompatibility complex, class II, DR beta 1
hsa:3586 IL10; interleukin 10
hsa:3606 IL18; interleukin 18 (interferon-gamma-inducing factor)
hsa:3552 IL1A; interleukin 1, alpha
hsa:3553 IL1B; interleukin 1, beta
hsa:3569 IL6; interleukin 6 (interferon, beta 2)
hsa:4843 NOS2; nitric oxide synthase 2, inducible (EC:1.14.13.39)
hsa:7040 TGFB1; transforming growth factor, beta 1
hsa:7097 TLR2; toll-like receptor 2
hsa:7099 TLR4; toll-like receptor 4
hsa:7124 TNF; tumor necrosis factor
hsa:7421 VDR; vitamin D (1,25- dihydroxyvitamin D3) receptor

hsa05142 Chagas disease (American trypanosomiasis) - Homo sapiens (human) (17)



hsa:1636 ACE; angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 (EC:3.4.15.1)
hsa:6347 CCL2; chemokine (C-C motif) ligand 2
hsa:6348 CCL3; chemokine (C-C motif) ligand 3
hsa:355 FAS; Fas (TNF receptor superfamily, member 6)
hsa:2767 GNA11; guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
hsa:3586 IL10; interleukin 10
hsa:3553 IL1B; interleukin 1, beta
hsa:3569 IL6; interleukin 6 (interferon, beta 2)
hsa:3576 IL8; interleukin 8
hsa:4843 NOS2; nitric oxide synthase 2, inducible (EC:1.14.13.39)
hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
hsa:5521 PPP2R2B; protein phosphatase 2, regulatory subunit B, beta (EC:3.1.3.16)
hsa:5054 SERPINE1; serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
hsa:7040 TGFB1; transforming growth factor, beta 1
hsa:7097 TLR2; toll-like receptor 2
hsa:7099 TLR4; toll-like receptor 4
hsa:7124 TNF; tumor necrosis factor

hsa05164 Influenza A - Homo sapiens (human) (17)



hsa:6347 CCL2; chemokine (C-C motif) ligand 2
hsa:5610 EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2 (EC:2.7.11.1 2.7.10.2)
hsa:355 FAS; Fas (TNF receptor superfamily, member 6)
hsa:2224 FDPS; farnesyl diphosphate synthase (EC:2.5.1.1 2.5.1.10)
hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26)
hsa:3123 HLA-DRB1; major histocompatibility complex, class II, DR beta 1
hsa:3304 HSPA1B; heat shock 70kDa protein 1B
hsa:3383 ICAM1; intercellular adhesion molecule 1
hsa:3606 IL18; interleukin 18 (interferon-gamma-inducing factor)
hsa:3552 IL1A; interleukin 1, alpha
hsa:3553 IL1B; interleukin 1, beta
hsa:90865 IL33; interleukin 33
hsa:3569 IL6; interleukin 6 (interferon, beta 2)
hsa:3576 IL8; interleukin 8
hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
hsa:7099 TLR4; toll-like receptor 4
hsa:7124 TNF; tumor necrosis factor

hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human) (16)



cpd:C00025 L-Glutamate
cpd:C16025 Ghrelin
hsa:153 ADRB1; adrenergic, beta-1-, receptor
hsa:154 ADRB2; adrenergic, beta-2-, receptor, surface
hsa:1136 CHRNA3; cholinergic receptor, nicotinic, alpha 3 (neuronal)
hsa:1137 CHRNA4; cholinergic receptor, nicotinic, alpha 4 (neuronal)
hsa:1139 CHRNA7; cholinergic receptor, nicotinic, alpha 7 (neuronal)
hsa:1141 CHRNB2; cholinergic receptor, nicotinic, beta 2 (neuronal)
hsa:2492 FSHR; follicle stimulating hormone receptor
hsa:2904 GRIN2B; glutamate receptor, ionotropic, N-methyl D-aspartate 2B
hsa:116443 GRIN3A; glutamate receptor, ionotropic, N-methyl-D-aspartate 3A
hsa:3362 HTR6; 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled
hsa:3363 HTR7; 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled
hsa:3973 LHCGR; luteinizing hormone/choriogonadotropin receptor
hsa:4158 MC2R; melanocortin 2 receptor (adrenocorticotropic hormone)
hsa:10886 NPFFR2; neuropeptide FF receptor 2

hsa05202 Transcriptional misregulation in cancer - Homo sapiens (human) (16)



hsa:904 CCNT1; cyclin T1
hsa:929 CD14; CD14 molecule
hsa:942 CD86; CD86 molecule
hsa:3087 HHEX; hematopoietically expressed homeobox
hsa:3479 IGF1; insulin-like growth factor 1 (somatomedin C)
hsa:3569 IL6; interleukin 6 (interferon, beta 2)
hsa:3576 IL8; interleukin 8
hsa:4314 MMP3; matrix metallopeptidase 3 (stromelysin 1, progelatinase) (EC:3.4.24.17)
hsa:4353 MPO; myeloperoxidase (EC:1.11.2.2)
hsa:4914 NTRK1; neurotrophic tyrosine kinase, receptor, type 1 (EC:2.7.10.1)
hsa:5327 PLAT; plasminogen activator, tissue (EC:3.4.21.68)
hsa:5328 PLAU; plasminogen activator, urokinase (EC:3.4.21.73)
hsa:5468 PPARG; peroxisome proliferator-activated receptor gamma
hsa:861 RUNX1; runt-related transcription factor 1
hsa:6256 RXRA; retinoid X receptor, alpha
hsa:7157 TP53; tumor protein p53

hsa00190 Oxidative phosphorylation - Homo sapiens (human) (15)



hsa:4508 ATP6; ATP synthase F0 subunit 6
hsa:4509 ATP8; ATP synthase F0 subunit 8
hsa:4512 COX1; cytochrome c oxidase subunit I
hsa:1352 COX10; COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase (yeast) (EC:2.5.1.-)
hsa:1355 COX15; COX15 homolog, cytochrome c oxidase assembly protein (yeast)
hsa:4513 COX2; cytochrome c oxidase subunit II
hsa:4514 COX3; cytochrome c oxidase III
hsa:4519 CYTB; cytochrome b
hsa:4535 ND1; NADH dehydrogenase, subunit 1 (complex I)
hsa:4536 ND2; MTND2
hsa:4537 ND3; NADH dehydrogenase, subunit 3 (complex I)
hsa:4538 ND4; NADH dehydrogenase, subunit 4 (complex I)
hsa:4539 ND4L; NADH dehydrogenase, subunit 4L (complex I)
hsa:4540 ND5; NADH dehydrogenase, subunit 5 (complex I)
hsa:4541 ND6; NADH dehydrogenase, subunit 6 (complex I)

hsa05144 Malaria - Homo sapiens (human) (14)



hsa:6347 CCL2; chemokine (C-C motif) ligand 2
hsa:948 CD36; CD36 molecule (thrombospondin receptor)
hsa:1378 CR1; complement component (3b/4b) receptor 1 (Knops blood group)
hsa:3383 ICAM1; intercellular adhesion molecule 1
hsa:3586 IL10; interleukin 10
hsa:3606 IL18; interleukin 18 (interferon-gamma-inducing factor)
hsa:3553 IL1B; interleukin 1, beta
hsa:3569 IL6; interleukin 6 (interferon, beta 2)
hsa:3576 IL8; interleukin 8
hsa:4035 LRP1; low density lipoprotein receptor-related protein 1
hsa:7040 TGFB1; transforming growth factor, beta 1
hsa:7097 TLR2; toll-like receptor 2
hsa:7099 TLR4; toll-like receptor 4
hsa:7124 TNF; tumor necrosis factor

hsa04060 Cytokine-cytokine receptor interaction - Homo sapiens (human) (14)



hsa:6347 CCL2; chemokine (C-C motif) ligand 2
hsa:6348 CCL3; chemokine (C-C motif) ligand 3
hsa:729230 CCR2; chemokine (C-C motif) receptor 2
hsa:1435 CSF1; colony stimulating factor 1 (macrophage) (EC:2.7.10.1)
hsa:355 FAS; Fas (TNF receptor superfamily, member 6)
hsa:3586 IL10; interleukin 10
hsa:3606 IL18; interleukin 18 (interferon-gamma-inducing factor)
hsa:3552 IL1A; interleukin 1, alpha
hsa:3553 IL1B; interleukin 1, beta
IL1RN belongs here
hsa:3569 IL6; interleukin 6 (interferon, beta 2)
hsa:3576 IL8; interleukin 8
hsa:7040 TGFB1; transforming growth factor, beta 1
hsa:7124 TNF; tumor necrosis factor
hsa:7422 VEGFA; vascular endothelial growth factor A

hsa05016 Huntington's disease - Homo sapiens (human) (14)



cpd:C00025 L-Glutamate
hsa:4508 ATP6; ATP synthase F0 subunit 6
hsa:4509 ATP8; ATP synthase F0 subunit 8
hsa:627 BDNF; brain-derived neurotrophic factor
hsa:4512 COX1; cytochrome c oxidase subunit I
hsa:4513 COX2; cytochrome c oxidase subunit II
hsa:4514 COX3; cytochrome c oxidase III
hsa:4519 CYTB; cytochrome b
hsa:2876 GPX1; glutathione peroxidase 1 (EC:1.11.1.9)
hsa:2904 GRIN2B; glutamate receptor, ionotropic, N-methyl D-aspartate 2B
hsa:5468 PPARG; peroxisome proliferator-activated receptor gamma
hsa:6648 SOD2; superoxide dismutase 2, mitochondrial (EC:1.15.1.1)
hsa:7019 TFAM; transcription factor A, mitochondrial
hsa:7157 TP53; tumor protein p53

hsa03320 PPAR signaling pathway - Homo sapiens (human) (13)



hsa:335 APOA1; apolipoprotein A-I
hsa:116519 APOA5; apolipoprotein A-V
hsa:345 APOC3; apolipoprotein C-III
hsa:948 CD36; CD36 molecule (thrombospondin receptor)
hsa:3158 HMGCS2; 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) (EC:2.3.3.10)
hsa:4023 LPL; lipoprotein lipase (EC:3.1.1.34)
hsa:4312 MMP1; matrix metallopeptidase 1 (interstitial collagenase) (EC:3.4.24.7)
hsa:4973 OLR1; oxidized low density lipoprotein (lectin-like) receptor 1
hsa:5105 PCK1; phosphoenolpyruvate carboxykinase 1 (soluble) (EC:4.1.1.32)
hsa:5360 PLTP; phospholipid transfer protein
hsa:5465 PPARA; peroxisome proliferator-activated receptor alpha
hsa:5468 PPARG; peroxisome proliferator-activated receptor gamma
hsa:6256 RXRA; retinoid X receptor, alpha

hsa05146 Amoebiasis - Homo sapiens (human) (13)



hsa:929 CD14; CD14 molecule
hsa:1301 COL11A1; collagen, type XI, alpha 1
hsa:2767 GNA11; guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
hsa:3586 IL10; interleukin 10
hsa:3553 IL1B; interleukin 1, beta
hsa:3569 IL6; interleukin 6 (interferon, beta 2)
hsa:3576 IL8; interleukin 8
hsa:4843 NOS2; nitric oxide synthase 2, inducible (EC:1.14.13.39)
hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
hsa:7040 TGFB1; transforming growth factor, beta 1
hsa:7097 TLR2; toll-like receptor 2
hsa:7099 TLR4; toll-like receptor 4
hsa:7124 TNF; tumor necrosis factor

hsa05168 Herpes simplex infection - Homo sapiens (human) (12)



hsa:6347 CCL2; chemokine (C-C motif) ligand 2
hsa:5610 EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2 (EC:2.7.11.1 2.7.10.2)
hsa:355 FAS; Fas (TNF receptor superfamily, member 6)
hsa:3123 HLA-DRB1; major histocompatibility complex, class II, DR beta 1
hsa:3553 IL1B; interleukin 1, beta
hsa:3569 IL6; interleukin 6 (interferon, beta 2)
hsa:5819 PVRL2; poliovirus receptor-related 2 (herpesvirus entry mediator B)
hsa:6891 TAP2; transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
hsa:7097 TLR2; toll-like receptor 2
hsa:7124 TNF; tumor necrosis factor
hsa:7157 TP53; tumor protein p53
hsa:7186 TRAF2; TNF receptor-associated factor 2

hsa05162 Measles - Homo sapiens (human) (12)



hsa:5610 EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2 (EC:2.7.11.1 2.7.10.2)
hsa:355 FAS; Fas (TNF receptor superfamily, member 6)
hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26)
hsa:3304 HSPA1B; heat shock 70kDa protein 1B
hsa:3552 IL1A; interleukin 1, alpha
hsa:3553 IL1B; interleukin 1, beta
hsa:3569 IL6; interleukin 6 (interferon, beta 2)
hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
hsa:7097 TLR2; toll-like receptor 2
hsa:7099 TLR4; toll-like receptor 4
hsa:7157 TP53; tumor protein p53
hsa:7161 TP73; tumor protein p73

hsa05133 Pertussis - Homo sapiens (human) (12)



cpd:C00253 Nicotinate
hsa:720 C4A; complement component 4A (Rodgers blood group)
hsa:721 C4B; complement component 4B (Chido blood group)
hsa:929 CD14; CD14 molecule
hsa:3586 IL10; interleukin 10
hsa:3552 IL1A; interleukin 1, alpha
hsa:3553 IL1B; interleukin 1, beta
hsa:3569 IL6; interleukin 6 (interferon, beta 2)
hsa:3576 IL8; interleukin 8
hsa:4843 NOS2; nitric oxide synthase 2, inducible (EC:1.14.13.39)
hsa:7099 TLR4; toll-like receptor 4
hsa:7124 TNF; tumor necrosis factor

hsa05160 Hepatitis C - Homo sapiens (human) (12)



hsa:5610 EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2 (EC:2.7.11.1 2.7.10.2)
hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26)
hsa:3576 IL8; interleukin 8
hsa:3949 LDLR; low density lipoprotein receptor
hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
hsa:5465 PPARA; peroxisome proliferator-activated receptor alpha
hsa:5521 PPP2R2B; protein phosphatase 2, regulatory subunit B, beta (EC:3.1.3.16)
hsa:6256 RXRA; retinoid X receptor, alpha
hsa:6655 SOS2; son of sevenless homolog 2 (Drosophila)
hsa:7124 TNF; tumor necrosis factor
hsa:7157 TP53; tumor protein p53
hsa:7186 TRAF2; TNF receptor-associated factor 2

hsa04640 Hematopoietic cell lineage - Homo sapiens (human) (11)



hsa:929 CD14; CD14 molecule
hsa:945 CD33; CD33 molecule
hsa:948 CD36; CD36 molecule (thrombospondin receptor)
hsa:1378 CR1; complement component (3b/4b) receptor 1 (Knops blood group)
hsa:1435 CSF1; colony stimulating factor 1 (macrophage) (EC:2.7.10.1)
hsa:3123 HLA-DRB1; major histocompatibility complex, class II, DR beta 1
hsa:3552 IL1A; interleukin 1, alpha
hsa:3553 IL1B; interleukin 1, beta
hsa:3569 IL6; interleukin 6 (interferon, beta 2)
hsa:4311 MME; membrane metallo-endopeptidase (EC:3.4.24.11)
hsa:7124 TNF; tumor necrosis factor

hsa04610 Complement and coagulation cascades - Homo sapiens (human) (11)



hsa:2 A2M; alpha-2-macroglobulin
hsa:720 C4A; complement component 4A (Rodgers blood group)
hsa:721 C4B; complement component 4B (Chido blood group)
hsa:3075 CFH; complement factor H (EC:4.2.1.2)
hsa:1378 CR1; complement component (3b/4b) receptor 1 (Knops blood group)
hsa:2162 F13A1; coagulation factor XIII, A1 polypeptide (EC:2.3.2.13)
hsa:5327 PLAT; plasminogen activator, tissue (EC:3.4.21.68)
hsa:5328 PLAU; plasminogen activator, urokinase (EC:3.4.21.73)
hsa:5265 SERPINA1; serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
hsa:5054 SERPINE1; serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
hsa:5345 SERPINF2; serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2
CLU Clusterin belongs here 

hsa05145 Toxoplasmosis - Homo sapiens (human) (11)



hsa:3123 HLA-DRB1; major histocompatibility complex, class II, DR beta 1
hsa:3304 HSPA1B; heat shock 70kDa protein 1B
hsa:3586 IL10; interleukin 10
hsa:3949 LDLR; low density lipoprotein receptor
hsa:4843 NOS2; nitric oxide synthase 2, inducible (EC:1.14.13.39)
hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
hsa:50487 PLA2G3; phospholipase A2, group III (EC:3.1.1.4)
hsa:7040 TGFB1; transforming growth factor, beta 1
hsa:7097 TLR2; toll-like receptor 2
hsa:7099 TLR4; toll-like receptor 4
hsa:7124 TNF; tumor necrosis factor

hsa05140 Leishmaniasis - Homo sapiens (human) (11)



hsa:1378 CR1; complement component (3b/4b) receptor 1 (Knops blood group)
hsa:3123 HLA-DRB1; major histocompatibility complex, class II, DR beta 1
hsa:3586 IL10; interleukin 10
hsa:3552 IL1A; interleukin 1, alpha
hsa:3553 IL1B; interleukin 1, beta
hsa:4843 NOS2; nitric oxide synthase 2, inducible (EC:1.14.13.39)
hsa:5743 PTGS2; prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1)
hsa:7040 TGFB1; transforming growth factor, beta 1
hsa:7097 TLR2; toll-like receptor 2
hsa:7099 TLR4; toll-like receptor 4
hsa:7124 TNF; tumor necrosis factor

hsa05134 Legionellosis - Homo sapiens (human) (11)



hsa:929 CD14; CD14 molecule
hsa:1378 CR1; complement component (3b/4b) receptor 1 (Knops blood group)
hsa:3304 HSPA1B; heat shock 70kDa protein 1B
hsa:3606 IL18; interleukin 18 (interferon-gamma-inducing factor)
hsa:3553 IL1B; interleukin 1, beta
hsa:3569 IL6; interleukin 6 (interferon, beta 2)
hsa:3576 IL8; interleukin 8
hsa:7097 TLR2; toll-like receptor 2
hsa:7099 TLR4; toll-like receptor 4
hsa:7124 TNF; tumor necrosis factor
hsa:7415 VCP; valosin containing protein

hsa02010 ABC transporters - Homo sapiens (human) (11)



cpd:C00025 L-Glutamate
cpd:C00031 D-Glucose
cpd:C00051 Glutathione
cpd:C00378 Thiamine
cpd:C05776 Vitamin B12
hsa:19 ABCA1; ATP-binding cassette, sub-family A (ABC1), member 1
hsa:20 ABCA2; ATP-binding cassette, sub-family A (ABC1), member 2
hsa:10347 ABCA7; ATP-binding cassette, sub-family A (ABC1), member 7
hsa:1244 ABCC2; ATP-binding cassette, sub-family C (CFTR/MRP), member 2
hsa:9619 ABCG1; ATP-binding cassette, sub-family G (WHITE), member 1
hsa:6891 TAP2; transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)

hsa04722 Neurotrophin signaling pathway - Homo sapiens (human) (11)



hsa:627 BDNF; brain-derived neurotrophic factor
hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26)
hsa:4914 NTRK1; neurotrophic tyrosine kinase, receptor, type 1 (EC:2.7.10.1)
hsa:4915 NTRK2; neurotrophic tyrosine kinase, receptor, type 2 (EC:2.7.10.1)
hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
hsa:5663 PSEN1; presenilin 1 (EC:3.4.23.-)
hsa:5664 PSEN2; presenilin 2 (Alzheimer disease 4)
hsa:6655 SOS2; son of sevenless homolog 2 (Drosophila)
hsa:7157 TP53; tumor protein p53
hsa:7161 TP73; tumor protein p73
hsa:7534 YWHAZ; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide

hsa04380 Osteoclast differentiation - Homo sapiens (human) (10)



hsa:1435 CSF1; colony stimulating factor 1 (macrophage) (EC:2.7.10.1)
hsa:9846 GAB2; GRB2-associated binding protein 2
hsa:3552 IL1A; interleukin 1, alpha
hsa:3553 IL1B; interleukin 1, beta
hsa:3932 LCK; lymphocyte-specific protein tyrosine kinase (EC:2.7.10.2)
hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
hsa:5468 PPARG; peroxisome proliferator-activated receptor gamma
hsa:7040 TGFB1; transforming growth factor, beta 1
hsa:7124 TNF; tumor necrosis factor
hsa:7186 TRAF2; TNF receptor-associated factor 2

hsa05132 Salmonella infection - Homo sapiens (human) (10)



hsa:6348 CCL3; chemokine (C-C motif) ligand 3
hsa:929 CD14; CD14 molecule
hsa:3606 IL18; interleukin 18 (interferon-gamma-inducing factor)
hsa:3552 IL1A; interleukin 1, alpha
hsa:3553 IL1B; interleukin 1, beta
hsa:3569 IL6; interleukin 6 (interferon, beta 2)
hsa:3576 IL8; interleukin 8
hsa:3831 KLC1; kinesin light chain 1
hsa:4843 NOS2; nitric oxide synthase 2, inducible (EC:1.14.13.39)
hsa:7099 TLR4; toll-like receptor 4

hsa05166 HTLV-I infection - Homo sapiens (human) (10)



hsa:2224 FDPS; farnesyl diphosphate synthase (EC:2.5.1.1 2.5.1.10)
hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26)
hsa:3123 HLA-DRB1; major histocompatibility complex, class II, DR beta 1
hsa:3383 ICAM1; intercellular adhesion molecule 1
hsa:3569 IL6; interleukin 6 (interferon, beta 2)
hsa:3932 LCK; lymphocyte-specific protein tyrosine kinase (EC:2.7.10.2)
hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
hsa:7040 TGFB1; transforming growth factor, beta 1
hsa:7124 TNF; tumor necrosis factor
hsa:7157 TP53; tumor protein p53

hsa04726 Serotonergic synapse - Homo sapiens (human) (10)



cpd:C00078 L-Tryptophan
hsa:351 APP; amyloid beta (A4) precursor protein
hsa:2784 GNB3; guanine nucleotide binding protein (G protein), beta polypeptide 3
hsa:3362 HTR6; 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled
hsa:3363 HTR7; 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled
hsa:3763 KCNJ6; potassium inwardly-rectifying channel, subfamily J, member 6
hsa:4128 MAOA; monoamine oxidase A (EC:1.4.3.4)
hsa:50487 PLA2G3; phospholipase A2, group III (EC:3.1.1.4)
hsa:5743 PTGS2; prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1)
hsa:6532 SLC6A4; solute carrier family 6 (neurotransmitter transporter, serotonin), member 4

hsa04975 Fat digestion and absorption - Homo sapiens (human) (10)



cpd:C00162 Fatty acid
cpd:C00187 Cholesterol
cpd:C00422 Triacylglycerol
cpd:C02530 Cholesterol ester
hsa:19 ABCA1; ATP-binding cassette, sub-family A (ABC1), member 1
hsa:10554 AGPAT1; 1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha) (EC:2.3.1.51)
hsa:335 APOA1; apolipoprotein A-I
hsa:337 APOA4; apolipoprotein A-IV
hsa:948 CD36; CD36 molecule (thrombospondin receptor)
hsa:50487 PLA2G3; phospholipase A2, group III (EC:3.1.1.4)

hsa04620 Toll-like receptor signaling pathway - Homo sapiens (human) (10)



hsa:6348 CCL3; chemokine (C-C motif) ligand 3
hsa:929 CD14; CD14 molecule
hsa:942 CD86; CD86 molecule
hsa:3553 IL1B; interleukin 1, beta
hsa:3569 IL6; interleukin 6 (interferon, beta 2)
hsa:3576 IL8; interleukin 8
hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
hsa:7097 TLR2; toll-like receptor 2
hsa:7099 TLR4; toll-like receptor 4
hsa:7124 TNF; tumor necrosis factor

hsa04145 Phagosome - Homo sapiens (human) (10)



hsa:929 CD14; CD14 molecule
hsa:948 CD36; CD36 molecule (thrombospondin receptor)
hsa:1520 CTSS; cathepsin S (EC:3.4.22.27)
hsa:3123 HLA-DRB1; major histocompatibility complex, class II, DR beta 1
hsa:4353 MPO; myeloperoxidase (EC:1.11.2.2)
hsa:4842 NOS1; nitric oxide synthase 1 (neuronal) (EC:1.14.13.39)
hsa:4973 OLR1; oxidized low density lipoprotein (lectin-like) receptor 1
hsa:6891 TAP2; transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
hsa:7097 TLR2; toll-like receptor 2
hsa:7099 TLR4; toll-like receptor 4

hsa05169 Epstein-Barr virus infection - Homo sapiens (human) (10)



hsa:5610 EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2 (EC:2.7.11.1 2.7.10.2)
hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26)
hsa:3123 HLA-DRB1; major histocompatibility complex, class II, DR beta 1
hsa:3304 HSPA1B; heat shock 70kDa protein 1B
hsa:3383 ICAM1; intercellular adhesion molecule 1
hsa:3586 IL10; interleukin 10
hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
hsa:7157 TP53; tumor protein p53
hsa:7186 TRAF2; TNF receptor-associated factor 2
hsa:7534 YWHAZ; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide

hsa04020 Calcium signaling pathway - Homo sapiens (human) (10)



hsa:153 ADRB1; adrenergic, beta-1-, receptor
hsa:154 ADRB2; adrenergic, beta-2-, receptor, surface
hsa:1139 CHRNA7; cholinergic receptor, nicotinic, alpha 7 (neuronal)
hsa:2767 GNA11; guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
hsa:3362 HTR6; 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled
hsa:3363 HTR7; 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled
hsa:3973 LHCGR; luteinizing hormone/choriogonadotropin receptor
hsa:4842 NOS1; nitric oxide synthase 1 (neuronal) (EC:1.14.13.39)
hsa:4843 NOS2; nitric oxide synthase 2, inducible (EC:1.14.13.39)
hsa:4846 NOS3; nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39)

hsa04976 Bile secretion - Homo sapiens (human) (9)



cpd:C00031 D-Glucose
cpd:C00051 Glutathione
cpd:C00187 Cholesterol
cpd:C00504 Folate
cpd:C02530 Cholesterol ester
hsa:1244 ABCC2; ATP-binding cassette, sub-family C (CFTR/MRP), member 2
hsa:3156 HMGCR; 3-hydroxy-3-methylglutaryl-CoA reductase (EC:1.1.1.34)
hsa:3949 LDLR; low density lipoprotein receptor
hsa:6256 RXRA; retinoid X receptor, alpha

hsa00330 Arginine and proline metabolism - Homo sapiens (human) (9)



cpd:C00019 S-Adenosyl-L-methionine
cpd:C00025 L-Glutamate
hsa:5832 ALDH18A1; aldehyde dehydrogenase 18 family, member A1 (EC:1.2.1.41 2.7.2.11)
hsa:217 ALDH2; aldehyde dehydrogenase 2 family (mitochondrial) (EC:1.2.1.3)
hsa:4128 MAOA; monoamine oxidase A (EC:1.4.3.4)
hsa:4842 NOS1; nitric oxide synthase 1 (neuronal) (EC:1.14.13.39)
hsa:4843 NOS2; nitric oxide synthase 2, inducible (EC:1.14.13.39)
hsa:4846 NOS3; nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39)
hsa:5009 OTC; ornithine carbamoyltransferase (EC:2.1.3.3)

hsa05143 African trypanosomiasis - Homo sapiens (human) (9)



cpd:C00078 L-Tryptophan
hsa:335 APOA1; apolipoprotein A-I
hsa:355 FAS; Fas (TNF receptor superfamily, member 6)
hsa:3383 ICAM1; intercellular adhesion molecule 1
hsa:3586 IL10; interleukin 10
hsa:3606 IL18; interleukin 18 (interferon-gamma-inducing factor)
hsa:3553 IL1B; interleukin 1, beta
hsa:3569 IL6; interleukin 6 (interferon, beta 2)
hsa:7124 TNF; tumor necrosis factor

hsa04144 Endocytosis - Homo sapiens (human) (9)



cpd:C00504 Folate
hsa:153 ADRB1; adrenergic, beta-1-, receptor
hsa:154 ADRB2; adrenergic, beta-2-, receptor, surface
hsa:857 CAV1; caveolin 1, caveolae protein, 22kDa
hsa:1785 DNM2; dynamin 2 (EC:3.6.5.5)
hsa:3304 HSPA1B; heat shock 70kDa protein 1B
hsa:3949 LDLR; low density lipoprotein receptor
hsa:4914 NTRK1; neurotrophic tyrosine kinase, receptor, type 1 (EC:2.7.10.1)
hsa:7040 TGFB1; transforming growth factor, beta 1
PICALM phosphatidylinositol binding clathrin assembly protein belongs here 

hsa04621 NOD-like receptor signaling pathway - Homo sapiens (human) (9)



hsa:22900 CARD8; caspase recruitment domain family, member 8
hsa:6347 CCL2; chemokine (C-C motif) ligand 2
hsa:3606 IL18; interleukin 18 (interferon-gamma-inducing factor)
hsa:3553 IL1B; interleukin 1, beta
hsa:3569 IL6; interleukin 6 (interferon, beta 2)
hsa:3576 IL8; interleukin 8
hsa:4210 MEFV; Mediterranean fever
hsa:22861 NLRP1; NLR family, pyrin domain containing 1
hsa:7124 TNF; tumor necrosis factor

hsa04725 Cholinergic synapse - Homo sapiens (human) (9)



hsa:1103 CHAT; choline O-acetyltransferase (EC:2.3.1.6)
hsa:1136 CHRNA3; cholinergic receptor, nicotinic, alpha 3 (neuronal)
hsa:1137 CHRNA4; cholinergic receptor, nicotinic, alpha 4 (neuronal)
hsa:1139 CHRNA7; cholinergic receptor, nicotinic, alpha 7 (neuronal)
hsa:1141 CHRNB2; cholinergic receptor, nicotinic, beta 2 (neuronal)
hsa:2767 GNA11; guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
hsa:2784 GNB3; guanine nucleotide binding protein (G protein), beta polypeptide 3
hsa:3763 KCNJ6; potassium inwardly-rectifying channel, subfamily J, member 6
hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha)

hsa00480 Glutathione metabolism - Homo sapiens (human) (9)



cpd:C00025 L-Glutamate
cpd:C00051 Glutathione
cpd:C00072 Ascorbate
hsa:2876 GPX1; glutathione peroxidase 1 (EC:1.11.1.9)
hsa:2944 GSTM1; glutathione S-transferase mu 1 (EC:2.5.1.18)
hsa:2947 GSTM3; glutathione S-transferase mu 3 (brain) (EC:2.5.1.18)
hsa:9446 GSTO1; glutathione S-transferase omega 1 (EC:2.5.1.18 1.8.5.1 1.20.4.2)
hsa:2950 GSTP1; glutathione S-transferase pi 1 (EC:2.5.1.18)
hsa:2952 GSTT1; glutathione S-transferase theta 1 (EC:2.5.1.18)

hsa05215 Prostate cancer - Homo sapiens (human) (9)



cpd:C00535 Testosterone
cpd:C00951 Estradiol-17beta
hsa:367 AR; androgen receptor
hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26)
hsa:2950 GSTP1; glutathione S-transferase pi 1 (EC:2.5.1.18)
hsa:3479 IGF1; insulin-like growth factor 1 (somatomedin C)
hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
hsa:6655 SOS2; son of sevenless homolog 2 (Drosophila)
hsa:7157 TP53; tumor protein p53

hsa04142 Lysosome - Homo sapiens (human) (8)



hsa:20 ABCA2; ATP-binding cassette, sub-family A (ABC1), member 2
hsa:410 ARSA; arylsulfatase A (EC:3.1.6.8)
hsa:411 ARSB; arylsulfatase B (EC:3.1.6.12)
hsa:1509 CTSD; cathepsin D (EC:3.4.23.5)
hsa:1520 CTSS; cathepsin S (EC:3.4.22.27)
hsa:3988 LIPA; lipase A, lysosomal acid, cholesterol esterase (EC:3.1.1.13)
hsa:4864 NPC1; Niemann-Pick disease, type C1
hsa:10577 NPC2; Niemann-Pick disease, type C2

hsa04210 Apoptosis - Homo sapiens (human) (8)



hsa:355 FAS; Fas (TNF receptor superfamily, member 6)
hsa:3552 IL1A; interleukin 1, alpha
hsa:3553 IL1B; interleukin 1, beta
hsa:4914 NTRK1; neurotrophic tyrosine kinase, receptor, type 1 (EC:2.7.10.1)
hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
hsa:7124 TNF; tumor necrosis factor
hsa:7157 TP53; tumor protein p53
hsa:7186 TRAF2; TNF receptor-associated factor 2

hsa04062 Chemokine signaling pathway - Homo sapiens (human) (8)



hsa:6347 CCL2; chemokine (C-C motif) ligand 2
hsa:6348 CCL3; chemokine (C-C motif) ligand 3
hsa:729230 CCR2; chemokine (C-C motif) receptor 2
hsa:2784 GNB3; guanine nucleotide binding protein (G protein), beta polypeptide 3
hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26)
hsa:3576 IL8; interleukin 8
hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
hsa:6655 SOS2; son of sevenless homolog 2 (Drosophila)

hsa05034 Alcoholism - Homo sapiens (human) (8)



cpd:C00025 L-Glutamate
hsa:627 BDNF; brain-derived neurotrophic factor
hsa:2784 GNB3; guanine nucleotide binding protein (G protein), beta polypeptide 3
hsa:2904 GRIN2B; glutamate receptor, ionotropic, N-methyl D-aspartate 2B
hsa:116443 GRIN3A; glutamate receptor, ionotropic, N-methyl-D-aspartate 3A
hsa:4128 MAOA; monoamine oxidase A (EC:1.4.3.4)
hsa:4915 NTRK2; neurotrophic tyrosine kinase, receptor, type 2 (EC:2.7.10.1)
hsa:6655 SOS2; son of sevenless homolog 2 (Drosophila)

hsa04141 Protein processing in endoplasmic reticulum - Homo sapiens (human) (8)



hsa:5610 EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2 (EC:2.7.11.1 2.7.10.2)
hsa:3304 HSPA1B; heat shock 70kDa protein 1B
hsa:3309 HSPA5; heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
hsa:4780 NFE2L2; nuclear factor (erythroid-derived 2)-like 2
hsa:6400 SEL1L; sel-1 suppressor of lin-12-like (C. elegans)
hsa:7186 TRAF2; TNF receptor-associated factor 2
hsa:29979 UBQLN1; ubiquilin 1
hsa:7415 VCP; valosin containing protein

hsa05322 Systemic lupus erythematosus - Homo sapiens (human) (8)



hsa:720 C4A; complement component 4A (Rodgers blood group)
hsa:721 C4B; complement component 4B (Chido blood group)
hsa:942 CD86; CD86 molecule
hsa:2904 GRIN2B; glutamate receptor, ionotropic, N-methyl D-aspartate 2B
hsa:3123 HLA-DRB1; major histocompatibility complex, class II, DR beta 1
hsa:3586 IL10; interleukin 10
hsa:6741 SSB; Sjogren syndrome antigen B (autoantigen La)
hsa:7124 TNF; tumor necrosis factor

hsa04510 Focal adhesion - Homo sapiens (human) (8)



hsa:857 CAV1; caveolin 1, caveolae protein, 22kDa
hsa:1301 COL11A1; collagen, type XI, alpha 1
hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26)
hsa:3479 IGF1; insulin-like growth factor 1 (somatomedin C)
hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
hsa:5649 RELN; reelin
hsa:6655 SOS2; son of sevenless homolog 2 (Drosophila)
hsa:7422 VEGFA; vascular endothelial growth factor A

hsa04650 Natural killer cell mediated cytotoxicity - Homo sapiens (human) (8)



hsa:355 FAS; Fas (TNF receptor superfamily, member 6)
hsa:2207 FCER1G; Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
hsa:3383 ICAM1; intercellular adhesion molecule 1
hsa:3932 LCK; lymphocyte-specific protein tyrosine kinase (EC:2.7.10.2)
hsa:100507436 MICA; MHC class I polypeptide-related sequence A
hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
hsa:6655 SOS2; son of sevenless homolog 2 (Drosophila)
hsa:7124 TNF; tumor necrosis factor

hsa00970 Aminoacyl-tRNA biosynthesis - Homo sapiens (human) (8)



cpd:C00025 L-Glutamate
cpd:C00078 L-Tryptophan
hsa:4563 TRNG; tRNA-Gly
hsa:4564 TRNH; tRNA-His
hsa:4572 TRNQ; tRNA-Gln
hsa:4573 TRNR; tRNA-Arg
hsa:4575 TRNS2; tRNA-Ser
hsa:4576 TRNT; tRNA-Thr

hsa04664 Fc epsilon RI signaling pathway - Homo sapiens (human) (7)



hsa:2207 FCER1G; Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
hsa:9846 GAB2; GRB2-associated binding protein 2
hsa:2206 MS4A2; membrane-spanning 4-domains, subfamily A, member 2
hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
hsa:50487 PLA2G3; phospholipase A2, group III (EC:3.1.1.4)
hsa:6655 SOS2; son of sevenless homolog 2 (Drosophila)
hsa:7124 TNF; tumor necrosis factor

hsa05014 Amyotrophic lateral sclerosis (ALS) - Homo sapiens (human) (7)



cpd:C00025 L-Glutamate
hsa:2876 GPX1; glutathione peroxidase 1 (EC:1.11.1.9)
hsa:2904 GRIN2B; glutamate receptor, ionotropic, N-methyl D-aspartate 2B
hsa:4842 NOS1; nitric oxide synthase 1 (neuronal) (EC:1.14.13.39)
hsa:7124 TNF; tumor necrosis factor
hsa:10452 TOMM40; translocase of outer mitochondrial membrane 40 homolog (yeast)
hsa:7157 TP53; tumor protein p53

hsa04910 Insulin signaling pathway - Homo sapiens (human) (7)



cpd:C00031 D-Glucose
hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26)
hsa:5105 PCK1; phosphoenolpyruvate carboxykinase 1 (soluble) (EC:4.1.1.32)
hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
hsa:5506 PPP1R3A; protein phosphatase 1, regulatory subunit 3A (EC:3.1.3.16)
hsa:6655 SOS2; son of sevenless homolog 2 (Drosophila)
hsa:6720 SREBF1; sterol regulatory element binding transcription factor 1

hsa05030 Cocaine addiction - Homo sapiens (human) (7)



cpd:C00025 L-Glutamate
hsa:627 BDNF; brain-derived neurotrophic factor
hsa:1020 CDK5; cyclin-dependent kinase 5 (EC:2.7.11.22)
hsa:8851 CDK5R1; cyclin-dependent kinase 5, regulatory subunit 1 (p35)
hsa:2904 GRIN2B; glutamate receptor, ionotropic, N-methyl D-aspartate 2B
hsa:116443 GRIN3A; glutamate receptor, ionotropic, N-methyl-D-aspartate 3A
hsa:4128 MAOA; monoamine oxidase A (EC:1.4.3.4)

hsa05410 Hypertrophic cardiomyopathy (HCM) - Homo sapiens (human) (7)



hsa:1636 ACE; angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 (EC:3.4.15.1)
hsa:783 CACNB2; calcium channel, voltage-dependent, beta 2 subunit
hsa:3479 IGF1; insulin-like growth factor 1 (somatomedin C)
hsa:3569 IL6; interleukin 6 (interferon, beta 2)
hsa:4000 LMNA; lamin A/C
hsa:7040 TGFB1; transforming growth factor, beta 1
hsa:7124 TNF; tumor necrosis factor

hsa05332 Graft-versus-host disease - Homo sapiens (human) (7)



hsa:942 CD86; CD86 molecule
hsa:355 FAS; Fas (TNF receptor superfamily, member 6)
hsa:3123 HLA-DRB1; major histocompatibility complex, class II, DR beta 1
hsa:3552 IL1A; interleukin 1, alpha
hsa:3553 IL1B; interleukin 1, beta
hsa:3569 IL6; interleukin 6 (interferon, beta 2)
hsa:7124 TNF; tumor necrosis factor

hsa04728 Dopaminergic synapse - Homo sapiens (human) (7)



hsa:1312 COMT; catechol-O-methyltransferase (EC:2.1.1.6)
hsa:2784 GNB3; guanine nucleotide binding protein (G protein), beta polypeptide 3
hsa:2904 GRIN2B; glutamate receptor, ionotropic, N-methyl D-aspartate 2B
hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26)
hsa:3763 KCNJ6; potassium inwardly-rectifying channel, subfamily J, member 6
hsa:4128 MAOA; monoamine oxidase A (EC:1.4.3.4)
hsa:5521 PPP2R2B; protein phosphatase 2, regulatory subunit B, beta (EC:3.1.3.16)

hsa05220 Chronic myeloid leukemia - Homo sapiens (human) (7)



hsa:613 BCR; breakpoint cluster region (EC:2.7.11.1)
hsa:9846 GAB2; GRB2-associated binding protein 2
hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
hsa:861 RUNX1; runt-related transcription factor 1
hsa:6655 SOS2; son of sevenless homolog 2 (Drosophila)
hsa:7040 TGFB1; transforming growth factor, beta 1
hsa:7157 TP53; tumor protein p53

hsa04920 Adipocytokine signaling pathway - Homo sapiens (human) (7)



cpd:C00162 Fatty acid
hsa:948 CD36; CD36 molecule (thrombospondin receptor)
hsa:5105 PCK1; phosphoenolpyruvate carboxykinase 1 (soluble) (EC:4.1.1.32)
hsa:5465 PPARA; peroxisome proliferator-activated receptor alpha
hsa:6256 RXRA; retinoid X receptor, alpha
hsa:7124 TNF; tumor necrosis factor
hsa:7186 TRAF2; TNF receptor-associated factor 2

hsa00100 Steroid biosynthesis - Homo sapiens (human) (7)



cpd:C00187 Cholesterol
cpd:C02530 Cholesterol ester
cpd:C05441 Vitamin D2
cpd:C05443 Vitamin D3
hsa:1718 DHCR24; 24-dehydrocholesterol reductase (EC:1.3.1.72)
hsa:3988 LIPA; lipase A, lysosomal acid, cholesterol esterase (EC:3.1.1.13)
hsa:6646 SOAT1; sterol O-acyltransferase 1 (EC:2.3.1.26)

hsa00010 Glycolysis / Gluconeogenesis - Homo sapiens (human) (6)



cpd:C00031 D-Glucose
hsa:217 ALDH2; aldehyde dehydrogenase 2 family (mitochondrial) (EC:1.2.1.3)
hsa:1738 DLD; dihydrolipoamide dehydrogenase (EC:1.8.1.4)
hsa:2597 GAPDH; glyceraldehyde-3-phosphate dehydrogenase (EC:1.2.1.12)
hsa:26330 GAPDHS; glyceraldehyde-3-phosphate dehydrogenase, spermatogenic (EC:1.2.1.12)
hsa:5105 PCK1; phosphoenolpyruvate carboxykinase 1 (soluble) (EC:4.1.1.32)

hsa05033 Nicotine addiction - Homo sapiens (human) (6)



cpd:C00025 L-Glutamate
hsa:1137 CHRNA4; cholinergic receptor, nicotinic, alpha 4 (neuronal)
hsa:1139 CHRNA7; cholinergic receptor, nicotinic, alpha 7 (neuronal)
hsa:1141 CHRNB2; cholinergic receptor, nicotinic, beta 2 (neuronal)
hsa:2904 GRIN2B; glutamate receptor, ionotropic, N-methyl D-aspartate 2B
hsa:116443 GRIN3A; glutamate receptor, ionotropic, N-methyl-D-aspartate 3A

hsa04612 Antigen processing and presentation - Homo sapiens (human) (6)



hsa:1520 CTSS; cathepsin S (EC:3.4.22.27)
hsa:3123 HLA-DRB1; major histocompatibility complex, class II, DR beta 1
hsa:3304 HSPA1B; heat shock 70kDa protein 1B
hsa:3309 HSPA5; heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
hsa:6891 TAP2; transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
hsa:7124 TNF; tumor necrosis factor

hsa04940 Type I diabetes mellitus - Homo sapiens (human) (6)



hsa:942 CD86; CD86 molecule
hsa:355 FAS; Fas (TNF receptor superfamily, member 6)
hsa:3123 HLA-DRB1; major histocompatibility complex, class II, DR beta 1
hsa:3552 IL1A; interleukin 1, alpha
hsa:3553 IL1B; interleukin 1, beta
hsa:7124 TNF; tumor necrosis factor

hsa05222 Small cell lung cancer - Homo sapiens (human) (6)



hsa:4843 NOS2; nitric oxide synthase 2, inducible (EC:1.14.13.39)
hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
hsa:5743 PTGS2; prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1)
hsa:6256 RXRA; retinoid X receptor, alpha
hsa:7157 TP53; tumor protein p53
hsa:7186 TRAF2; TNF receptor-associated factor 2

hsa00982 Drug metabolism - cytochrome P450 - Homo sapiens (human) (6)



hsa:2944 GSTM1; glutathione S-transferase mu 1 (EC:2.5.1.18)
hsa:2947 GSTM3; glutathione S-transferase mu 3 (brain) (EC:2.5.1.18)
hsa:9446 GSTO1; glutathione S-transferase omega 1 (EC:2.5.1.18 1.8.5.1 1.20.4.2)
hsa:2950 GSTP1; glutathione S-transferase pi 1 (EC:2.5.1.18)
hsa:2952 GSTT1; glutathione S-transferase theta 1 (EC:2.5.1.18)
hsa:4128 MAOA; monoamine oxidase A (EC:1.4.3.4)

hsa05020 Prion diseases - Homo sapiens (human) (6)



hsa:3309 HSPA5; heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
hsa:3552 IL1A; interleukin 1, alpha
hsa:3553 IL1B; interleukin 1, beta
hsa:3569 IL6; interleukin 6 (interferon, beta 2)
hsa:4685 NCAM2; neural cell adhesion molecule 2
hsa:5621 PRNP; prion protein

hsa05414 Dilated cardiomyopathy - Homo sapiens (human) (6)



hsa:153 ADRB1; adrenergic, beta-1-, receptor
hsa:783 CACNB2; calcium channel, voltage-dependent, beta 2 subunit
hsa:3479 IGF1; insulin-like growth factor 1 (somatomedin C)
hsa:4000 LMNA; lamin A/C
hsa:7040 TGFB1; transforming growth factor, beta 1
hsa:7124 TNF; tumor necrosis factor

hsa05416 Viral myocarditis - Homo sapiens (human) (6)



hsa:857 CAV1; caveolin 1, caveolae protein, 22kDa
hsa:942 CD86; CD86 molecule
hsa:3123 HLA-DRB1; major histocompatibility complex, class II, DR beta 1
hsa:3383 ICAM1; intercellular adhesion molecule 1
hsa:8735 MYH13; myosin, heavy chain 13, skeletal muscle
hsa:4626 MYH8; myosin, heavy chain 8, skeletal muscle, perinatal

hsa04660 T cell receptor signaling pathway - Homo sapiens (human) (6)



hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26)
hsa:3586 IL10; interleukin 10
hsa:3932 LCK; lymphocyte-specific protein tyrosine kinase (EC:2.7.10.2)
hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
hsa:6655 SOS2; son of sevenless homolog 2 (Drosophila)
hsa:7124 TNF; tumor necrosis factor

hsa00140 Steroid hormone biosynthesis - Homo sapiens (human) (6)



cpd:C00187 Cholesterol
cpd:C00535 Testosterone
cpd:C00951 Estradiol-17beta
hsa:1312 COMT; catechol-O-methyltransferase (EC:2.1.1.6)
hsa:1588 CYP19A1; cytochrome P450, family 19, subfamily A, polypeptide 1 (EC:1.14.14.1)
hsa:3290 HSD11B1; hydroxysteroid (11-beta) dehydrogenase 1 (EC:1.1.1.146)

hsa05150 Staphylococcus aureus infection - Homo sapiens (human) (6)



hsa:720 C4A; complement component 4A (Rodgers blood group)
hsa:721 C4B; complement component 4B (Chido blood group)
hsa:3075 CFH; complement factor H (EC:4.2.1.2)
hsa:3123 HLA-DRB1; major histocompatibility complex, class II, DR beta 1
hsa:3383 ICAM1; intercellular adhesion molecule 1
hsa:3586 IL10; interleukin 10

hsa00980 Metabolism of xenobiotics by cytochrome P450 - Homo sapiens (human) (6)



hsa:2944 GSTM1; glutathione S-transferase mu 1 (EC:2.5.1.18)
hsa:2947 GSTM3; glutathione S-transferase mu 3 (brain) (EC:2.5.1.18)
hsa:9446 GSTO1; glutathione S-transferase omega 1 (EC:2.5.1.18 1.8.5.1 1.20.4.2)
hsa:2950 GSTP1; glutathione S-transferase pi 1 (EC:2.5.1.18)
hsa:2952 GSTT1; glutathione S-transferase theta 1 (EC:2.5.1.18)
hsa:3290 HSD11B1; hydroxysteroid (11-beta) dehydrogenase 1 (EC:1.1.1.146)

hsa00561 Glycerolipid metabolism - Homo sapiens (human) (6)



cpd:C00162 Fatty acid
cpd:C00422 Triacylglycerol
hsa:10554 AGPAT1; 1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha) (EC:2.3.1.51)
hsa:217 ALDH2; aldehyde dehydrogenase 2 family (mitochondrial) (EC:1.2.1.3)
hsa:3990 LIPC; lipase, hepatic (EC:3.1.1.3)
hsa:4023 LPL; lipoprotein lipase (EC:3.1.1.34)

hsa05330 Allograft rejection - Homo sapiens (human) (5)



hsa:942 CD86; CD86 molecule
hsa:355 FAS; Fas (TNF receptor superfamily, member 6)
hsa:3123 HLA-DRB1; major histocompatibility complex, class II, DR beta 1
hsa:3586 IL10; interleukin 10
hsa:7124 TNF; tumor necrosis factor

hsa04370 VEGF signaling pathway - Homo sapiens (human) (5)



hsa:4846 NOS3; nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39)
hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
hsa:50487 PLA2G3; phospholipase A2, group III (EC:3.1.1.4)
hsa:5743 PTGS2; prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1)
hsa:7422 VEGFA; vascular endothelial growth factor A

hsa05031 Amphetamine addiction - Homo sapiens (human) (5)



cpd:C00025 L-Glutamate
hsa:23237 ARC; activity-regulated cytoskeleton-associated protein
hsa:2904 GRIN2B; glutamate receptor, ionotropic, N-methyl D-aspartate 2B
hsa:116443 GRIN3A; glutamate receptor, ionotropic, N-methyl-D-aspartate 3A
hsa:4128 MAOA; monoamine oxidase A (EC:1.4.3.4)

hsa04514 Cell adhesion molecules (CAMs) - Homo sapiens (human) (5)



hsa:942 CD86; CD86 molecule
hsa:3123 HLA-DRB1; major histocompatibility complex, class II, DR beta 1
hsa:3383 ICAM1; intercellular adhesion molecule 1
hsa:4685 NCAM2; neural cell adhesion molecule 2
hsa:5819 PVRL2; poliovirus receptor-related 2 (herpesvirus entry mediator B)

hsa04310 Wnt signaling pathway - Homo sapiens (human) (5)



hsa:22943 DKK1; dickkopf 1 homolog (Xenopus laevis)
hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26)
hsa:4040 LRP6; low density lipoprotein receptor-related protein 6
hsa:5663 PSEN1; presenilin 1 (EC:3.4.23.-)
hsa:7157 TP53; tumor protein p53

hsa04978 Mineral absorption - Homo sapiens (human) (5)



cpd:C00031 D-Glucose
cpd:C00078 L-Tryptophan
hsa:3162 HMOX1; heme oxygenase (decycling) 1 (EC:1.14.99.3)
hsa:7018 TF; transferrin
hsa:7421 VDR; vitamin D (1,25- dihydroxyvitamin D3) receptor

hsa04110 Cell cycle - Homo sapiens (human) (5)



hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26)
hsa:5933 RBL1; retinoblastoma-like 1 (p107)
hsa:7040 TGFB1; transforming growth factor, beta 1
hsa:7157 TP53; tumor protein p53
hsa:7534 YWHAZ; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide

hsa04623 Cytosolic DNA-sensing pathway - Homo sapiens (human) (5)



hsa:3606 IL18; interleukin 18 (interferon-gamma-inducing factor)
hsa:3553 IL1B; interleukin 1, beta
hsa:90865 IL33; interleukin 33
hsa:3569 IL6; interleukin 6 (interferon, beta 2)
hsa:81030 ZBP1; Z-DNA binding protein 1

hsa04330 Notch signaling pathway - Homo sapiens (human) (5)



hsa:51107 APH1A; anterior pharynx defective 1 homolog A (C. elegans)
hsa:23385 NCSTN; nicastrin
hsa:5663 PSEN1; presenilin 1 (EC:3.4.23.-)
hsa:5664 PSEN2; presenilin 2 (Alzheimer disease 4)
hsa:55851 PSENEN; presenilin enhancer 2 homolog (C. elegans)

hsa04360 Axon guidance - Homo sapiens (human) (5)



hsa:1020 CDK5; cyclin-dependent kinase 5 (EC:2.7.11.22)
hsa:1808 DPYSL2; dihydropyrimidinase-like 2
hsa:1946 EFNA5; ephrin-A5
hsa:2041 EPHA1; EPH receptor A1 (EC:2.7.10.1)
hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26)

hsa00270 Cysteine and methionine metabolism - Homo sapiens (human) (5)



cpd:C00019 S-Adenosyl-L-methionine
cpd:C00051 Glutathione
cpd:C00155 L-Homocysteine
hsa:875 CBS; cystathionine-beta-synthase (EC:4.2.1.22)
hsa:4548 MTR; 5-methyltetrahydrofolate-homocysteine methyltransferase (EC:2.1.1.13)
MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase belongs here 

hsa00380 Tryptophan metabolism - Homo sapiens (human) (5)



cpd:C00078 L-Tryptophan
cpd:C01717 4-Hydroxy-2-quinolinecarboxylic acid
cpd:C03722 Quinolinate
hsa:217 ALDH2; aldehyde dehydrogenase 2 family (mitochondrial) (EC:1.2.1.3)
hsa:4128 MAOA; monoamine oxidase A (EC:1.4.3.4)

hsa05213 Endometrial cancer - Homo sapiens (human) (5)



hsa:29119 CTNNA3; catenin (cadherin-associated protein), alpha 3
hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26)
hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
hsa:6655 SOS2; son of sevenless homolog 2 (Drosophila)
hsa:7157 TP53; tumor protein p53

hsa00830 Retinol metabolism - Homo sapiens (human) (5)



cpd:C00376 Retinal
cpd:C00473 Retinol
cpd:C02075 Retinyl ester
cpd:C02094 beta-Carotene
hsa:9227 LRAT; lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase) (EC:2.3.1.135)

hsa05219 Bladder cancer - Homo sapiens (human) (5)



hsa:1612 DAPK1; death-associated protein kinase 1 (EC:2.7.11.1)
hsa:3576 IL8; interleukin 8
hsa:4312 MMP1; matrix metallopeptidase 1 (interstitial collagenase) (EC:3.4.24.7)
hsa:7157 TP53; tumor protein p53
hsa:7422 VEGFA; vascular endothelial growth factor A

hsa04530 Tight junction - Homo sapiens (human) (5)



hsa:29119 CTNNA3; catenin (cadherin-associated protein), alpha 3
hsa:9863 MAGI2; membrane associated guanylate kinase, WW and PDZ domain containing 2
hsa:8735 MYH13; myosin, heavy chain 13, skeletal muscle
hsa:4626 MYH8; myosin, heavy chain 8, skeletal muscle, perinatal
hsa:5521 PPP2R2B; protein phosphatase 2, regulatory subunit B, beta (EC:3.1.3.16)

hsa04672 Intestinal immune network for IgA production - Homo sapiens (human) (5)



hsa:942 CD86; CD86 molecule
hsa:3123 HLA-DRB1; major histocompatibility complex, class II, DR beta 1
hsa:3586 IL10; interleukin 10
hsa:3569 IL6; interleukin 6 (interferon, beta 2)
hsa:7040 TGFB1; transforming growth factor, beta 1

hsa05100 Bacterial invasion of epithelial cells - Homo sapiens (human) (5)



hsa:857 CAV1; caveolin 1, caveolae protein, 22kDa
hsa:23607 CD2AP; CD2-associated protein
hsa:29119 CTNNA3; catenin (cadherin-associated protein), alpha 3
hsa:1785 DNM2; dynamin 2 (EC:3.6.5.5)
hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha)

hsa05310 Asthma - Homo sapiens (human) (5)



hsa:2207 FCER1G; Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
hsa:3123 HLA-DRB1; major histocompatibility complex, class II, DR beta 1
hsa:3586 IL10; interleukin 10
hsa:2206 MS4A2; membrane-spanning 4-domains, subfamily A, member 2
hsa:7124 TNF; tumor necrosis factor

hsa04730 Long-term depression - Homo sapiens (human) (5)



cpd:C00025 L-Glutamate
hsa:2767 GNA11; guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
hsa:3479 IGF1; insulin-like growth factor 1 (somatomedin C)
hsa:4842 NOS1; nitric oxide synthase 1 (neuronal) (EC:1.14.13.39)
hsa:50487 PLA2G3; phospholipase A2, group III (EC:3.1.1.4)

hsa04260 Cardiac muscle contraction - Homo sapiens (human) (5)



hsa:783 CACNB2; calcium channel, voltage-dependent, beta 2 subunit
hsa:4512 COX1; cytochrome c oxidase subunit I
hsa:4513 COX2; cytochrome c oxidase subunit II
hsa:4514 COX3; cytochrome c oxidase III
hsa:4519 CYTB; cytochrome b

hsa04724 Glutamatergic synapse - Homo sapiens (human) (5)



cpd:C00025 L-Glutamate
hsa:2784 GNB3; guanine nucleotide binding protein (G protein), beta polypeptide 3
hsa:2904 GRIN2B; glutamate receptor, ionotropic, N-methyl D-aspartate 2B
hsa:116443 GRIN3A; glutamate receptor, ionotropic, N-methyl-D-aspartate 3A
hsa:50487 PLA2G3; phospholipase A2, group III (EC:3.1.1.4)

hsa04115 p53 signaling pathway - Homo sapiens (human) (5)



hsa:355 FAS; Fas (TNF receptor superfamily, member 6)
hsa:3479 IGF1; insulin-like growth factor 1 (somatomedin C)
hsa:5054 SERPINE1; serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
hsa:7157 TP53; tumor protein p53
hsa:7161 TP73; tumor protein p73

hsa04810 Regulation of actin cytoskeleton - Homo sapiens (human) (4)



hsa:929 CD14; CD14 molecule
hsa:2246 FGF1; fibroblast growth factor 1 (acidic)
hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
hsa:6655 SOS2; son of sevenless homolog 2 (Drosophila)

hsa00670 One carbon pool by folate - Homo sapiens (human) (4)



cpd:C00504 Folate
hsa:25902 MTHFD1L; methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like (EC:6.3.4.3)
hsa:4524 MTHFR; methylenetetrahydrofolate reductase (NAD(P)H) (EC:1.5.1.20)
hsa:4548 MTR; 5-methyltetrahydrofolate-homocysteine methyltransferase (EC:2.1.1.13)
MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase belongs here 

hsa04540 Gap junction - Homo sapiens (human) (4)



cpd:C00025 L-Glutamate
hsa:153 ADRB1; adrenergic, beta-1-, receptor
hsa:2767 GNA11; guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
hsa:6655 SOS2; son of sevenless homolog 2 (Drosophila)

hsa05210 Colorectal cancer - Homo sapiens (human) (4)



hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26)
hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
hsa:7040 TGFB1; transforming growth factor, beta 1
hsa:7157 TP53; tumor protein p53

hsa05223 Non-small cell lung cancer - Homo sapiens (human) (4)



hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
hsa:6256 RXRA; retinoid X receptor, alpha
hsa:6655 SOS2; son of sevenless homolog 2 (Drosophila)
hsa:7157 TP53; tumor protein p53

hsa00280 Valine, leucine and isoleucine degradation - Homo sapiens (human) (4)



hsa:27034 ACAD8; acyl-CoA dehydrogenase family, member 8
hsa:217 ALDH2; aldehyde dehydrogenase 2 family (mitochondrial) (EC:1.2.1.3)
hsa:1738 DLD; dihydrolipoamide dehydrogenase (EC:1.8.1.4)
hsa:3158 HMGCS2; 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) (EC:2.3.3.10)

hsa04723 Retrograde endocannabinoid signaling - Homo sapiens (human) (4)



cpd:C00025 L-Glutamate
hsa:2784 GNB3; guanine nucleotide binding protein (G protein), beta polypeptide 3
hsa:3763 KCNJ6; potassium inwardly-rectifying channel, subfamily J, member 6
hsa:5743 PTGS2; prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1)

hsa04512 ECM-receptor interaction - Homo sapiens (human) (4)



hsa:948 CD36; CD36 molecule (thrombospondin receptor)
hsa:1301 COL11A1; collagen, type XI, alpha 1
hsa:3339 HSPG2; heparan sulfate proteoglycan 2
hsa:5649 RELN; reelin

hsa05320 Autoimmune thyroid disease - Homo sapiens (human) (4)



hsa:942 CD86; CD86 molecule
hsa:355 FAS; Fas (TNF receptor superfamily, member 6)
hsa:3123 HLA-DRB1; major histocompatibility complex, class II, DR beta 1
hsa:3586 IL10; interleukin 10

hsa00260 Glycine, serine and threonine metabolism - Homo sapiens (human) (4)



cpd:C00078 L-Tryptophan
hsa:875 CBS; cystathionine-beta-synthase (EC:4.2.1.22)
hsa:1738 DLD; dihydrolipoamide dehydrogenase (EC:1.8.1.4)
hsa:4128 MAOA; monoamine oxidase A (EC:1.4.3.4)

hsa05211 Renal cell carcinoma - Homo sapiens (human) (4)



hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
hsa:6655 SOS2; son of sevenless homolog 2 (Drosophila)
hsa:7040 TGFB1; transforming growth factor, beta 1
hsa:7422 VEGFA; vascular endothelial growth factor A

hsa05218 Melanoma - Homo sapiens (human) (4)



hsa:2246 FGF1; fibroblast growth factor 1 (acidic)
hsa:3479 IGF1; insulin-like growth factor 1 (somatomedin C)
hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
hsa:7157 TP53; tumor protein p53

hsa05216 Thyroid cancer - Homo sapiens (human) (4)



hsa:4914 NTRK1; neurotrophic tyrosine kinase, receptor, type 1 (EC:2.7.10.1)
hsa:5468 PPARG; peroxisome proliferator-activated receptor gamma
hsa:6256 RXRA; retinoid X receptor, alpha
hsa:7157 TP53; tumor protein p53

hsa04974 Protein digestion and absorption - Homo sapiens (human) (4)



cpd:C00025 L-Glutamate
cpd:C00078 L-Tryptophan
hsa:1301 COL11A1; collagen, type XI, alpha 1
hsa:4311 MME; membrane metallo-endopeptidase (EC:3.4.24.11)

hsa04727 GABAergic synapse - Homo sapiens (human) (4)



cpd:C00025 L-Glutamate
hsa:2784 GNB3; guanine nucleotide binding protein (G protein), beta polypeptide 3
hsa:3763 KCNJ6; potassium inwardly-rectifying channel, subfamily J, member 6
hsa:66008 TRAK2; trafficking protein, kinesin binding 2

hsa05214 Glioma - Homo sapiens (human) (4)



hsa:3479 IGF1; insulin-like growth factor 1 (somatomedin C)
hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
hsa:6655 SOS2; son of sevenless homolog 2 (Drosophila)
hsa:7157 TP53; tumor protein p53

hsa04970 Salivary secretion - Homo sapiens (human) (4)



hsa:153 ADRB1; adrenergic, beta-1-, receptor
hsa:154 ADRB2; adrenergic, beta-2-, receptor, surface
hsa:1471 CST3; cystatin C
hsa:4842 NOS1; nitric oxide synthase 1 (neuronal) (EC:1.14.13.39)

hsa04622 RIG-I-like receptor signaling pathway - Homo sapiens (human) (4)



hsa:3576 IL8; interleukin 8
hsa:5300 PIN1; peptidylprolyl cis/trans isomerase, NIMA-interacting 1 (EC:5.2.1.8)
hsa:7124 TNF; tumor necrosis factor
hsa:7186 TRAF2; TNF receptor-associated factor 2

hsa04630 Jak-STAT signaling pathway - Homo sapiens (human) (4)



hsa:3586 IL10; interleukin 10
hsa:3569 IL6; interleukin 6 (interferon, beta 2)
hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
hsa:6655 SOS2; son of sevenless homolog 2 (Drosophila)

hsa00350 Tyrosine metabolism - Homo sapiens (human) (4)



hsa:1312 COMT; catechol-O-methyltransferase (EC:2.1.1.6)
hsa:1621 DBH; dopamine beta-hydroxylase (dopamine beta-monooxygenase) (EC:1.14.17.1)
hsa:4128 MAOA; monoamine oxidase A (EC:1.4.3.4)
hsa:5409 PNMT; phenylethanolamine N-methyltransferase (EC:2.1.1.28)

hsa04930 Type II diabetes mellitus - Homo sapiens (human) (4)



cpd:C00031 D-Glucose
cpd:C00162 Fatty acid
hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
hsa:7124 TNF; tumor necrosis factor

hsa00120 Primary bile acid biosynthesis - Homo sapiens (human) (4)



cpd:C00187 Cholesterol
cpd:C13550 Cerebrosterol
hsa:9023 CH25H; cholesterol 25-hydroxylase (EC:1.14.99.38)
hsa:10858 CYP46A1; cytochrome P450, family 46, subfamily A, polypeptide 1 (EC:1.14.13.98)

hsa05212 Pancreatic cancer - Homo sapiens (human) (4)



hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
hsa:7040 TGFB1; transforming growth factor, beta 1
hsa:7157 TP53; tumor protein p53
hsa:7422 VEGFA; vascular endothelial growth factor A

hsa04961 Endocrine and other factor-regulated calcium reabsorption - Homo sapiens (human) (4)



cpd:C00951 Estradiol-17beta
hsa:1785 DNM2; dynamin 2 (EC:3.6.5.5)
hsa:2099 ESR1; estrogen receptor 1
hsa:7421 VDR; vitamin D (1,25- dihydroxyvitamin D3) receptor

hsa00860 Porphyrin and chlorophyll metabolism - Homo sapiens (human) (4)



cpd:C00025 L-Glutamate
hsa:1352 COX10; COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase (yeast) (EC:2.5.1.-)
hsa:1355 COX15; COX15 homolog, cytochrome c oxidase assembly protein (yeast)
hsa:3162 HMOX1; heme oxygenase (decycling) 1 (EC:1.14.99.3)

hsa04614 Renin-angiotensin system - Homo sapiens (human) (3)



hsa:1636 ACE; angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 (EC:3.4.15.1)
hsa:183 AGT; angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
hsa:4311 MME; membrane metallo-endopeptidase (EC:3.4.24.11)

hsa04150 mTOR signaling pathway - Homo sapiens (human) (3)



hsa:3479 IGF1; insulin-like growth factor 1 (somatomedin C)
hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
hsa:7422 VEGFA; vascular endothelial growth factor A

hsa00750 Vitamin B6 metabolism - Homo sapiens (human) (3)



cpd:C00018 Pyridoxal phosphate
cpd:C00250 Pyridoxal
cpd:C00534 Pyridoxamine

hsa04912 GnRH signaling pathway - Homo sapiens (human) (3)



hsa:2767 GNA11; guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
hsa:50487 PLA2G3; phospholipase A2, group III (EC:3.1.1.4)
hsa:6655 SOS2; son of sevenless homolog 2 (Drosophila)

hsa00590 Arachidonic acid metabolism - Homo sapiens (human) (3)



hsa:2876 GPX1; glutathione peroxidase 1 (EC:1.11.1.9)
hsa:50487 PLA2G3; phospholipase A2, group III (EC:3.1.1.4)
hsa:5743 PTGS2; prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1)

hsa00340 Histidine metabolism - Homo sapiens (human) (3)



cpd:C00025 L-Glutamate
hsa:217 ALDH2; aldehyde dehydrogenase 2 family (mitochondrial) (EC:1.2.1.3)
hsa:4128 MAOA; monoamine oxidase A (EC:1.4.3.4)

hsa05221 Acute myeloid leukemia - Homo sapiens (human) (3)



hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
hsa:861 RUNX1; runt-related transcription factor 1
hsa:6655 SOS2; son of sevenless homolog 2 (Drosophila)

hsa05130 Pathogenic Escherichia coli infection - Homo sapiens (human) (3)



hsa:929 CD14; CD14 molecule
hsa:7099 TLR4; toll-like receptor 4
hsa:7534 YWHAZ; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide

hsa00900 Terpenoid backbone biosynthesis - Homo sapiens (human) (3)



hsa:2224 FDPS; farnesyl diphosphate synthase (EC:2.5.1.1 2.5.1.10)
hsa:3156 HMGCR; 3-hydroxy-3-methylglutaryl-CoA reductase (EC:1.1.1.34)
hsa:3158 HMGCS2; 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) (EC:2.3.3.10)

hsa04340 Hedgehog signaling pathway - Homo sapiens (human) (3)



cpd:C00187 Cholesterol
hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26)
hsa:4036 LRP2; low density lipoprotein receptor-related protein 2

hsa05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) - Homo sapiens (human) (3)



hsa:783 CACNB2; calcium channel, voltage-dependent, beta 2 subunit
hsa:29119 CTNNA3; catenin (cadherin-associated protein), alpha 3
hsa:4000 LMNA; lamin A/C

hsa00620 Pyruvate metabolism - Homo sapiens (human) (3)



hsa:217 ALDH2; aldehyde dehydrogenase 2 family (mitochondrial) (EC:1.2.1.3)
hsa:1738 DLD; dihydrolipoamide dehydrogenase (EC:1.8.1.4)
hsa:5105 PCK1; phosphoenolpyruvate carboxykinase 1 (soluble) (EC:4.1.1.32)

hsa05120 Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human) (3)



hsa:102 ADAM10; ADAM metallopeptidase domain 10 (EC:3.4.24.81)
hsa:1445 CSK; c-src tyrosine kinase (EC:2.7.10.2)
hsa:3576 IL8; interleukin 8

hsa04012 ErbB signaling pathway - Homo sapiens (human) (3)



hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26)
hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
hsa:6655 SOS2; son of sevenless homolog 2 (Drosophila)

hsa04350 TGF-beta signaling pathway - Homo sapiens (human) (3)



hsa:5933 RBL1; retinoblastoma-like 1 (p107)
hsa:7040 TGFB1; transforming growth factor, beta 1
hsa:7124 TNF; tumor necrosis factor

hsa00020 Citrate cycle (TCA cycle) - Homo sapiens (human) (3)



hsa:1738 DLD; dihydrolipoamide dehydrogenase (EC:1.8.1.4)
hsa:1743 DLST; dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) (EC:2.3.1.61)
hsa:5105 PCK1; phosphoenolpyruvate carboxykinase 1 (soluble) (EC:4.1.1.32)

hsa04666 Fc gamma R-mediated phagocytosis - Homo sapiens (human) (3)



hsa:1785 DNM2; dynamin 2 (EC:3.6.5.5)
hsa:9846 GAB2; GRB2-associated binding protein 2
hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha)

hsa00564 Glycerophospholipid metabolism - Homo sapiens (human) (3)



hsa:10554 AGPAT1; 1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha) (EC:2.3.1.51)
hsa:1103 CHAT; choline O-acetyltransferase (EC:2.3.1.6)
hsa:50487 PLA2G3; phospholipase A2, group III (EC:3.1.1.4)

hsa01040 Biosynthesis of unsaturated fatty acids - Homo sapiens (human) (3)



cpd:C06427 (9Z,12Z,15Z)-Octadecatrienoic acid
cpd:C06429 (4Z,7Z,10Z,13Z,16Z,19Z)-Docosahexaenoic acid
hsa:9200 PTPLA; protein tyrosine phosphatase-like (proline instead of catalytic arginine), member A

hsa00760 Nicotinate and nicotinamide metabolism - Homo sapiens (human) (3)



cpd:C00253 Nicotinate
cpd:C03722 Quinolinate
hsa:349565 NMNAT3; nicotinamide nucleotide adenylyltransferase 3 (EC:2.7.7.1 2.7.7.18)

hsa04670 Leukocyte transendothelial migration - Homo sapiens (human) (3)



hsa:29119 CTNNA3; catenin (cadherin-associated protein), alpha 3
hsa:3383 ICAM1; intercellular adhesion molecule 1
hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha)

hsa04662 B cell receptor signaling pathway - Homo sapiens (human) (3)



hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26)
hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
hsa:6655 SOS2; son of sevenless homolog 2 (Drosophila)

hsa04114 Oocyte meiosis - Homo sapiens (human) (3)



hsa:367 AR; androgen receptor
hsa:3479 IGF1; insulin-like growth factor 1 (somatomedin C)
hsa:7534 YWHAZ; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide

hsa05217 Basal cell carcinoma - Homo sapiens (human) (3)



cpd:C00187 Cholesterol
hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26)
hsa:7157 TP53; tumor protein p53

hsa04270 Vascular smooth muscle contraction - Homo sapiens (human) (3)



hsa:2767 GNA11; guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
hsa:157855 KCNU1; potassium channel, subfamily U, member 1
hsa:50487 PLA2G3; phospholipase A2, group III (EC:3.1.1.4)

hsa00592 alpha-Linolenic acid metabolism - Homo sapiens (human) (2)



cpd:C06427 (9Z,12Z,15Z)-Octadecatrienoic acid
hsa:50487 PLA2G3; phospholipase A2, group III (EC:3.1.1.4)

hsa04122 Sulfur relay system - Homo sapiens (human) (2)



cpd:C00019 S-Adenosyl-L-methionine
cpd:C00378 Thiamine

hsa04964 Proximal tubule bicarbonate reclamation - Homo sapiens (human) (2)



cpd:C00025 L-Glutamate
hsa:5105 PCK1; phosphoenolpyruvate carboxykinase 1 (soluble) (EC:4.1.1.32)

hsa03030 DNA replication - Homo sapiens (human) (2)



hsa:5981 RFC1; replication factor C (activator 1) 1, 145kDa
hsa:5983 RFC3; replication factor C (activator 1) 3, 38kDa

hsa04973 Carbohydrate digestion and absorption - Homo sapiens (human) (2)



cpd:C00031 D-Glucose
hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha)

hsa00650 Butanoate metabolism - Homo sapiens (human) (2)



cpd:C00025 L-Glutamate
hsa:3158 HMGCS2; 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) (EC:2.3.3.10)

hsa00600 Sphingolipid metabolism - Homo sapiens (human) (2)



hsa:410 ARSA; arylsulfatase A (EC:3.1.6.8)
hsa:8879 SGPL1; sphingosine-1-phosphate lyase 1 (EC:4.1.2.27)

hsa04520 Adherens junction - Homo sapiens (human) (2)



hsa:29119 CTNNA3; catenin (cadherin-associated protein), alpha 3
hsa:5819 PVRL2; poliovirus receptor-related 2 (herpesvirus entry mediator B)

hsa04720 Long-term potentiation - Homo sapiens (human) (2)



cpd:C00025 L-Glutamate
hsa:2904 GRIN2B; glutamate receptor, ionotropic, N-methyl D-aspartate 2B

hsa04960 Aldosterone-regulated sodium reabsorption - Homo sapiens (human) (2)



hsa:3479 IGF1; insulin-like growth factor 1 (somatomedin C)
hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha)

hsa04721 Synaptic vesicle cycle - Homo sapiens (human) (2)



cpd:C00025 L-Glutamate
hsa:1785 DNM2; dynamin 2 (EC:3.6.5.5)

hsa03430 Mismatch repair - Homo sapiens (human) (2)



hsa:5981 RFC1; replication factor C (activator 1) 1, 145kDa
hsa:5983 RFC3; replication factor C (activator 1) 3, 38kDa

hsa05340 Primary immunodeficiency - Homo sapiens (human) (2)



hsa:3932 LCK; lymphocyte-specific protein tyrosine kinase (EC:2.7.10.2)
hsa:6891 TAP2; transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)

hsa03420 Nucleotide excision repair - Homo sapiens (human) (2)



hsa:5981 RFC1; replication factor C (activator 1) 1, 145kDa
hsa:5983 RFC3; replication factor C (activator 1) 3, 38kDa

hsa00071 Fatty acid metabolism - Homo sapiens (human) (2)



cpd:C00162 Fatty acid
hsa:217 ALDH2; aldehyde dehydrogenase 2 family (mitochondrial) (EC:1.2.1.3)

hsa04914 Progesterone-mediated oocyte maturation - Homo sapiens (human) (2)



hsa:3479 IGF1; insulin-like growth factor 1 (somatomedin C)
hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha)

hsa00062 Fatty acid elongation - Homo sapiens (human) (2)



cpd:C00162 Fatty acid
hsa:9200 PTPLA; protein tyrosine phosphatase-like (proline instead of catalytic arginine), member A

hsa05032 Morphine addiction - Homo sapiens (human) (2)



hsa:2784 GNB3; guanine nucleotide binding protein (G protein), beta polypeptide 3
hsa:3763 KCNJ6; potassium inwardly-rectifying channel, subfamily J, member 6

hsa00524 Butirosin and neomycin biosynthesis - Homo sapiens (human) (2)

cpd:C00025 L-Glutamate
cpd:C00031 D-Glucose

hsa04742 Taste transduction - Homo sapiens (human) (2)

cpd:C00025 L-Glutamate
hsa:2784 GNB3; guanine nucleotide binding protein (G protein), beta polypeptide 3

hsa04146 Peroxisome - Homo sapiens (human) (2)



hsa:4843 NOS2; nitric oxide synthase 2, inducible (EC:1.14.13.39)
hsa:6648 SOD2; superoxide dismutase 2, mitochondrial (EC:1.15.1.1)

hsa03410 Base excision repair - Homo sapiens (human) (2)



hsa:4968 OGG1; 8-oxoguanine DNA glycosylase (EC:4.2.99.18)
hsa:142 PARP1; poly (ADP-ribose) polymerase 1 (EC:2.4.2.30)

hsa00310 Lysine degradation - Homo sapiens (human) (2)



hsa:217 ALDH2; aldehyde dehydrogenase 2 family (mitochondrial) (EC:1.2.1.3)
hsa:1743 DLST; dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) (EC:2.3.1.61)

hsa03040 Spliceosome - Homo sapiens (human) (2)



hsa:51503 CWC15; CWC15 spliceosome-associated protein homolog (S. cerevisiae)
hsa:3304 HSPA1B; heat shock 70kDa protein 1B

hsa00053 Ascorbate and aldarate metabolism - Homo sapiens (human) (2)



cpd:C00072 Ascorbate
hsa:217 ALDH2; aldehyde dehydrogenase 2 family (mitochondrial) (EC:1.2.1.3)

hsa00410 beta-Alanine metabolism - Homo sapiens (human) (2)



cpd:C03722 Quinolinate
hsa:217 ALDH2; aldehyde dehydrogenase 2 family (mitochondrial) (EC:1.2.1.3)

hsa00052 Galactose metabolism - Homo sapiens (human) (1)

cpd:C00031 D-Glucose

hsa00983 Drug metabolism - other enzymes - Homo sapiens (human) (1)

hsa:10 NAT2; N-acetyltransferase 2 (arylamine N-acetyltransferase) (EC:2.3.1.5)

hsa00360 Phenylalanine metabolism - Homo sapiens (human) (1)

hsa:4128 MAOA; monoamine oxidase A (EC:1.4.3.4)

hsa00430 Taurine and hypotaurine metabolism - Homo sapiens (human) (1)

cpd:C00025 L-Glutamate

hsa04744 Phototransduction - Homo sapiens (human) (1)

cpd:C00376 Retinal

hsa00520 Amino sugar and nucleotide sugar metabolism - Homo sapiens (human) (1)

cpd:C00031 D-Glucose

hsa00030 Pentose phosphate pathway - Homo sapiens (human) (1)

cpd:C00031 D-Glucose

hsa00640 Propanoate metabolism - Homo sapiens (human) (1)

hsa:217 ALDH2; aldehyde dehydrogenase 2 family (mitochondrial) (EC:1.2.1.3)

hsa00630 Glyoxylate and dicarboxylate metabolism - Homo sapiens (human) (1)

cpd:C00025 L-Glutamate

hsa03013 RNA transport - Homo sapiens (human) (1)

hsa:7329 UBE2I; ubiquitin-conjugating enzyme E2I (EC:6.3.2.19)

hsa05131 Shigellosis - Homo sapiens (human) (1)

hsa:3576 IL8; interleukin 8

hsa00400 Phenylalanine, tyrosine and tryptophan biosynthesis - Homo sapiens (human) (1)

cpd:C00078 L-Tryptophan

hsa00230 Purine metabolism - Homo sapiens (human) (1)

hsa:5152 PDE9A; phosphodiesterase 9A (EC:3.1.4.35)

hsa00512 Mucin type O-Glycan biosynthesis - Homo sapiens (human) (1)

hsa:64409 WBSCR17; Williams-Beuren syndrome chromosome region 17 (EC:2.4.1.41)

hsa03060 Protein export - Homo sapiens (human) (1)

hsa:3309 HSPA5; heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)

hsa00250 Alanine, aspartate and glutamate metabolism - Homo sapiens (human) (1)

cpd:C00025 L-Glutamate

hsa00790 Folate biosynthesis - Homo sapiens (human) (1)

cpd:C00504 Folate

hsa00040 Pentose and glucuronate interconversions - Homo sapiens (human) (1)

hsa:217 ALDH2; aldehyde dehydrogenase 2 family (mitochondrial) (EC:1.2.1.3)

hsa00514 Other types of O-glycan biosynthesis - Homo sapiens (human) (1)

hsa:10585 POMT1; protein-O-mannosyltransferase 1 (EC:2.4.1.109)

hsa00072 Synthesis and degradation of ketone bodies - Homo sapiens (human) (1)

hsa:3158 HMGCS2; 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) (EC:2.3.3.10)

hsa04120 Ubiquitin mediated proteolysis - Homo sapiens (human) (1)

hsa:7329 UBE2I; ubiquitin-conjugating enzyme E2I (EC:6.3.2.19)

hsa04710 Circadian rhythm - mammal - Homo sapiens (human) (1)

hsa:4862 NPAS2; neuronal PAS domain protein 2

hsa04070 Phosphatidylinositol signaling system - Homo sapiens (human) (1)

hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha)

hsa00730 Thiamine metabolism - Homo sapiens (human) (1)

cpd:C00378 Thiamine

hsa00500 Starch and sucrose metabolism - Homo sapiens (human) (1)

cpd:C00031 D-Glucose

hsa00591 Linoleic acid metabolism - Homo sapiens (human) (1)

hsa:50487 PLA2G3; phospholipase A2, group III (EC:3.1.1.4)

hsa00232 Caffeine metabolism - Homo sapiens (human) (1)

hsa:10 NAT2; N-acetyltransferase 2 (arylamine N-acetyltransferase) (EC:2.3.1.5)

hsa04972 Pancreatic secretion - Homo sapiens (human) (1)

hsa:50487 PLA2G3; phospholipase A2, group III (EC:3.1.1.4)

hsa00450 Selenocompound metabolism - Homo sapiens (human) (1)

hsa:4548 MTR; 5-methyltetrahydrofolate-homocysteine methyltransferase (EC:2.1.1.13)
MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase belongs here 

hsa00130 Ubiquinone and other terpenoid-quinone biosynthesis - Homo sapiens (human) (1)

cpd:C02477 alpha-Tocopherol

hsa03015 mRNA surveillance pathway - Homo sapiens (human) (1)

hsa:5521 PPP2R2B; protein phosphatase 2, regulatory subunit B, beta (EC:3.1.3.16)

hsa00920 Sulfur metabolism - Homo sapiens (human) (1)

cpd:C00155 L-Homocysteine

hsa04971 Gastric acid secretion - Homo sapiens (human) (1)

hsa:6750 SST; somatostatin

hsa00565 Ether lipid metabolism - Homo sapiens (human) (1)

hsa:50487 PLA2G3; phospholipase A2, group III (EC:3.1.1.4)

hsa04950 Maturity onset diabetes of the young - Homo sapiens (human) (1)

hsa:3087 HHEX; hematopoietically expressed homeobox

hsa00531 Glycosaminoglycan degradation - Homo sapiens (human) (1)

hsa:411 ARSB; arylsulfatase B (EC:3.1.6.12)

hsa04320 Dorso-ventral axis formation - Homo sapiens (human) (1)

hsa:6655 SOS2; son of sevenless homolog 2 (Drosophila)

hsa00471 D-Glutamine and D-glutamate metabolism - Homo sapiens (human) (1)

cpd:C00025 L-Glutamate

hsa04916 Melanogenesis - Homo sapiens (human) (1)

hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26)

sss