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Other interactomes Host pathogen interactomes for Bornavirus; Candida albicans; Chlamydia Pneumoniae ; Cryptococcus Neoformans; Ebola virus; Epstein-Barr virus; Helicobacter pylori; Hepatitis C virus;Herpes simplex (HSV-1); HERV-W; HIV-1, Human Protein Interaction Database (NCBI); Human cytomegalovirus; Influenza A virus; Porphyromonas Gingivalis; Toxoplasma Gondii; Trypanosoma Cruzi : KEGG pathway analysis of these interactomes can be accessed here Medical News today Lyme disease

 

Host genes and proteins used by Borrelia burgdorferi during its life cycle.

If you know of other interactions, (or corrections) please with Pubmed ID, gene symbol/accession number and interacting protein. Thank you.

KEGG pathway interactome analysis

  1. A2M alpha-2-macroglobulin: Expression modified by B.Burgdorferi but not B. afzelii or B. garinii in fibroblasts Geca et al, 2012
  2. ACAN aggrecan: degraded by a Borrelia protease Russell and Johnson, 2013
  3. ACTR2 ARP2 actin-related protein 2 homolog : phagocytosis of Borrelia burgdorferi by primary human macrophages is controlled by CDC42 and Rac1 and involves recruitment of Wiskott-Aldrich syndrome protein and the Arp2/3 complex Linder et al, 2001
  4. ACTR3 ARP3 actin-related protein 3 homolog: phagocytosis of Borrelia burgdorferi by primary human macrophages is controlled by CDC42 and Rac1 and involves recruitment of Wiskott-Aldrich syndrome protein and the Arp2/3 complex Linder et al, 2001
  5. ADM adrenomedullin: B. burgdorferi increases the production of adrenomedullin, which negatively regulates the B. burgdorferi-stimulated inflammatory response Marre et al, 2010
  6. Adrenaline and noradrenaline bind to the spirochete Scheckelhoff et al, 2007
  7. AKT1 v-akt murine thymoma viral oncogene homolog 1 : B. burgdorferi activation of MyD88 or TLR3/TRIF signaling resulted in increased activity of AKT1 and PI3K in bone marrow derived macrophages Shin et al, 2009.
  8. ALOX5 arachidonate 5-lipoxygenase: ALOX5 and ALOX5AP mRNA induced in joints of Lyme arthritis-susceptible C3H/HeJ mice infected with Borrelia burgdorferi, leukotriene B(4) was produced Blaho et al, 2011
  9. ALOX5AP arachidonate 5-lipoxygenase-activating protein: ALOX5 and ALOX5AP mRNA induced in joints of Lyme arthritis-susceptible C3H/HeJ mice infected with Borrelia burgdorferi, leukotriene B(4) was produced Blaho et al, 2011
  10. AP3B1 adaptor related protein complex 3 beta 1 subunit : required for trafficking TLR2 purified ligands or Borrelia burgdorferi, to LAMP-1 lysosomal compartments
  11. APOB prevents the proinflammatory activity of Borrelia OspA and E. coli LPS in macrophages: APOA1, APOE2 and APOE3 are also effective but less so Bas et al, 2010
  12. APP amyloid beta (A4) precursor protein: Borrelia burgdorferi spirochetes and LPS induce beta-amyloid deposition and tau phosphorylation in mammalian glial and neuronal cells in vitro Miklossy et al, 2006
  13. ATG7 autophagy related 7 : ATG7-deficient mice that were intra-articular injected with Borrelia spirochetes displayed increased joint swelling, cell influx, and enhanced interleukin-1ß and interleukin-6 production by inflamed synovial tissue Buffen et al, 2016
  14. BCAN Brevican: degraded by a Borrelia protease Russell and Johnson, 2013
  15. BGN Biglycan: degraded by a Borrelia protease Russell and Johnson, 2013
  16. BMP2 bone morphogenetic protein 2: binds to borrelia CRASP1 protein Hallström et al, 2010
  17. BPI bactericidal/permeability-increasing protein : B. burgdorferi are killed by elastase, LL-37, BPI, and human neutrophil peptide-1 (DEFA1) Lusitani et al, 2002
  18. CAMP cathelicidin antimicrobial peptide (LL37) B. burgdorferi are killed by elastase, CAMP , BPI, and human neutrophil peptide-1 (DEFA1) Lusitani et al, 2002
  19. C1Q complement component 1, q subcomponent: Complement C1 ( C1QA C1QB, C1QC) bactericidal activity diminished in properdin-deficient sera as well as in a C1q- or C4-deficient serum van Dam et al, 1997
  20. C3 complement component 3: C3, C6, and the terminal complement complex are deposited on the spirochete Kraiczy et al, 2001
  21. C4 complement component 4 (C4A C4B) : complement components C3, C4 and C6 are deposited on the surface of Borrelia isolates VS116 and Bv9, and the membrane attack complex ( C5b, C6, C7, and C8) forms on their surface Schwab et al, 2013
  22. C4BPA complement component 4 binding protein, alpha: Binds to B.burgdorferi Pietikäinen et al, 2010
  23. C5 complement component 5 : Binds to the spirochete Kochi et al, 1991
  24. C6 complement component 6: C3, C6, and TCC are deposited on the spirochete Kraiczy et al, 2001
  25. C7 – complement component 7: Borrelial CspA binds the human terminal complement components C7 and C9 and blocks assembly and membrane insertion of the terminal complement complex Hallström et al, 2013
  26. C8A and C8B: complement component 8 antibody-sensitized borreliae bind C3, C8 and C9 Kochi et al, 1991
  27. C9 – complement component 9: Borrelial CspA binds the human terminal complement components C7 and C9 and blocks assembly and membrane insertion of the terminal complement complex Hallström et al, 2013
  28. CASP1 caspase 1, apoptosis-related cysteine peptidase : Borrelia species induce inflammasome activation and IL17 production via caspase-1-Oosting et al, 2011.
  29. CASP3 caspase 3 apoptosis-related cysteine peptidase : CASP3 dependent apoptosis activated by the spirochete in oligodendrocytes Ramesh et al, 2012
  30. CCL1 chemokine (C-C motif) ligand 1 : CCL1, CCL2 and CCL5 and CXCL1 induced by exposing chondrocytes to Borrelia protein BbHtrA in vitro Russell et al, 2013
  31. CCL2 – chemokine (C-C motif) ligand 2: Live B. burgdorferi induced elevated levels of IL6, IL8 and CCL2 in human Schwann cell and dorsal root ganglion cultures Ramesh et al, 2013
  32. CCL3 chemokine (C-C motif) ligand 3: IL6 and IL8, CCL2 (MCP-1), CCL3 (MIP-1alpha), CCL4 (MIP-1beta) and CCL5 (RANTES) released from cultured microglia by B. burgdorferi Myers et al, 2009
  33. CCL4 chemokine (C-C motif) ligand 4 : released from cultured microglia by B. burgdorferi Myers et al, 2009
  34. CCL5 chemokine (C-C motif) ligand 5: CCL1, CCL2 and CCL5 and CXCL1 induced by exposing chondrocytes to Borrelia protein BbHtrA in vitro Russell et al, 2013
  35. CCL7 chemokine (C-C motif) ligand 7 : B. burgdorferi and IFN-gamma (in primary human endothelial cells ) synergistically increase the expression of chemokines. , of which CCL7, CCL8, CX3CL1, CXCL9, CXCL10, and CXCL11 attract T lymphocytes, and CXCL2 is specific for neutrophils Dame et al, 2007.
  36. CCL8 chemokine (C-C motif) ligand 8 : see above Dame et al, 2007.
  37. CCL12 IFN-gamma and B. burgdorferi (in murine macrophages) synergistically induced chemoattractants for mononuclear cells (CXCL9, CXCL10, CXCL11, CXCL16, and CCL12) and decreased those for neutrophils (CXCL1, CXCL2, and CXCL3). IFN-gamma and B. burgdorferi also synergistically enhanced secretion of CXCL9 and CXCL10 by murine cardiac endothelial cells Sabino et al, 2011
  38. CCR2 CCR2(-/-) mice (C3H/HeJ strain) have severe inflammation but a decreased B. burgdorferi burden compared to wild type mice both at peak disease and during resolution Montgomery et al, 2007
  39. CCR7 chemokine (C-C motif) receptor 7 ; upregulated in immune dendritic cells by infection Love et al, 2014
  40. CD1A CD1B CD1C molecules: Borrelia burgdorferi triggers the appearance of group 1 CD1 proteins (CD1a, CD1b and CD1c) on human myeloid dendritic cells Yakimchuk et al, 2011
  41. CD1D molecule CD1d deficiency impairs murine host defense against the spirochete Kumar et al, 2000
  42. CD14 molecule: Induction of pro- and anti-inflammatory cytokines (IL1B, IL6, IL10) by Borrelia burgdorferi lipoproteins in monocytes is mediated by CD14 Giambartolomei et al, 1999.
  43. CD28 molecule: IL-4 production by T cells in B. burgdorferi-infected BALB/c mice is dependent upon CD86/CD28 interaction Shanafelt et al, 1998
  44. CD28 expression by mouse mast cells is modulated by lipopolysaccharide and outer surface protein A lipoprotein from Borrelia burgdorferi Marietta et al, 1997.
  45. CD40 CD40 molecule, TNF receptor superfamily member 5 : OspA of neuroinvasive Borrelia, but not of a non-neuroinvasive strain, binds to CD40 Pulzova et al, 2011
  46. CD59 CD59 molecule, complement regulatory protein : Serum-resistant strains of Borrelia burgdorferi express a CD59-like complement inhibitory molecule Pausa et al, 2003.
  47. CD69 molecule : T cell activation markers CD25 (IL2RA) , CD69 and CD71 (TFRC) induced by B.Burgdorferi outer surface protein C Salazar et al, 2005
  48. CD80 molecule: combined CD80/CD86 blockade resulted in preferential expansion of IFN-gamma-producing T cells in B. burgdorferi infection Shanafelt et al, 1998
  49. CD83 molecule : upregulated in immune dendritic cells by infection Love et al, 2014
  50. CD86 molecule: in the presence of Borrelia burgdorferi, synovial Vdelta1 T cells from Lyme arthritis synovial fluid potently induce maturation of DC, including production of IL-12, and increased surface expression of CD40 and CD86 Collins et al, 2005
  51. CD163L1 CD163 molecule-like : acts as a hybrid pattern recognition receptor and TCR coreceptor, and interacts with Leptospira spp. and Borrelia burgdorferi, but not with Escherichia coli or Staphylococcus aureus Hsu et al, 2015 .
  52. CDC42 cell division cycle 42: phagocytosis of Borrelia burgdorferi by primary human macrophages is controlled by CDC42 and Rac1 and involves recruitment of Wiskott-Aldrich syndrome protein and the Arp2/3 complex Linder et al, 2001
  53. CDH1 cadherin 1, type 1, E-cadherin (epithelial) : partially degraded by a Borrelia protease Russell and Johnson, 2013
  54. CEBPB CCAAT/enhancer binding protein (C/EBP), beta: Induced by spirochete infection in mouse macrophages Gautam et al, 2012
  55. CFB complement factor B: Expression modified by B.Burgdorferi but not B. afzelii or B. garinii in fibroblasts Geca et al, 2012
  56. CFH – complement factor H: binds to Borrelia burgdorferi Meri et al, 2013
  57. CFHR1 complement factor H-related 1: binds to 3 borrelial surface proteins (CRASP-3, -4, and -5) Haupt et al, 2007
  58. CFHR2 – complement factor H-related 2: ligand of Borrelia CRASP-4 Hammerschmidt et al, 2012
  59. CFHR5 complement factor H-related 5: ligand of Borrelia CRASP-4 Hammerschmidt et al, 2012
  60. CFP complement factor properdin: bactericidal activity diminished in properdin-deficient sera as well as in a C1q- or C4-deficient serum van Dam et al, 1997
  61. CHUK conserved helix-loop-helix ubiquitous kinase: B. burgdorferi induces nuclear translocation of NF-kappa B and a transient increase in the expression of its inhibitor I kappa B-alpha (CHUK) (human endothelial cells, keratinocytes, and fibroblasts).
  62. CSF2 colony stimulating factor 2 (granulocyte-macrophage): Release from Peripheral blood mononuclear cells stimulated by the spirochete Peripheral blood mononuclear cells Schempp et al, 1993
  63. COL1A1 collagen, type I, alpha 1: Borrelia protein CRASP-1 binds to human collagen types I (COL1A1/COL1A2, III (COL3A1) , and IV (COL4A1 to 4A6 ) Hallström et al, 2010
  64. COL6A1 collagen, type VI, alpha 1 (heterodimerises with COL6A2 and COL6A3) binds to the borrelia BBA33 lipoprotein Zhi et al, 2015
  65. CX3CL1 chemokine (C-X3-C motif) ligand 1 (fractalkine) : B. burgdorferi and IFN-gamma (in primary human endothelial cells ) synergistically increase the expression of chemokines. , of which CCL7, CCL8, CX3CL1, CXCL9, CXCL10, and CXCL11 attract T lymphocytes, and CXCL2 is specific for neutrophils Dame et al, 2007.
  66. CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha): CCL1, CCL2 and CCL5 and CXCL1 induced by exposing chondrocytes to Borrelia protein BbHtrA in vitro Russell et al, 2013
  67. CXCL2 B. burgdorferi and IFN-gamma (in primary human endothelial cells ) synergistically increase the expression of chemokines. , of which CCL7, CCL8, CX3CL1, CXCL9, CXCL10, and CXCL11 attract T lymphocytes, and CXCL2 is specific for neutrophils Dame et al, 2007.
  68. CXCL3 chemokine (C-X-C motif) ligand 3 :IFN-gamma and B. burgdorferi (in murine macrophages) synergistically induced chemoattractants for mononuclear cells (CXCL9, CXCL10, CXCL11, CXCL16, and CCL12) and decreased those for neutrophils (CXCL1, CXCL2, and CXCL3). IFN-gamma and B. burgdorferi also synergistically enhanced secretion of CXCL9 and CXCL10 by murine cardiac endothelial cells Sabino et al, 2011
  69. CXCL8 chemokine (C-X-C motif) ligand 8: heat-killed and sonicated bacteria release CCL2, IL6, and CXCL8 from oligodendrocytes Parthasarathy et al, 2013
  70. CXCL9 chemokine (C-X-C motif) ligand 9 : see Dame et al, 2007.
  71. CXCL10 chemokine (C-X-C motif) ligand 10 : see Dame et al, 2007.
  72. CXCL11 chemokine (C-X-C motif) ligand 11 : see Dame et al, 2007.
  73. CXCL13 Levels correlate with spirochetal load in Lyme neuroborreliosis Narayan et al, 2005
  74. CXCL16 Chemokine (C-X-C motif) ligand 16: IFN-gamma and B. burgdorferi (in murine macrophages) synergistically induced chemoattractants for mononuclear cells (CXCL9, CXCL10, CXCL11, CXCL16, and CCL12) and decreased those for neutrophils (CXCL1, CXCL2, and CXCL3). Sabino et al, 2011
  75. CXCR3 chemokine (C-X-C motif) receptor 3: After ingesting B. burgdorferi, Kupffer cells induce chemokine receptor CXCR3-dependent clustering of invariant natural killer T cells Lee et al, 2010.
  76. Cholesterol: spirochetes can acquire cholesterol from plasma membranes of epithelial cells Crowley et al, 2013.
  77. Chondroitin-6-sulfate: Borrelia burgdorferi surface-located membrane protein binds to chondroitin-6-sulfate Yang et al, 2015
  78. CRH corticotropin releasing hormone: upregulated by infection of astrocytes Ramesh et al, 2008
  79. DAAM1 dishevelled associated activator of morphogenesis 1 : Regulates filopodia formation and phagocytic uptake of Borrelia burgdorferi by primary human macrophages Hoffmann et al, 2014
  80. DCN Decorin: supports the attachment of B. burgdorferi Guo et al, 1995.degraded by a Borrelia protease Russell and Johnson, 2013
  81. DEFA1 defensin, alpha 1: B. burgdorferi are killed by elastase, CAMP , BPI, and human neutrophil peptide-1 (DEFA1) Lusitani et al, 2002
  82. DIAPH1 diaphanous-related formin 1: regulates phagocytosis of Borrelia burgdorferi by human macrophages Naj et al, 2013.
  83. ELANE elastase, neutrophil expressed: B. burgdorferi are killed by elastase, LL-37, bactericidal/permeability-increasing protein, and human neutrophil peptide-1 Lusitani et al, 2002
  84. FAM19A1 family with sequence similarity 19 (chemokine (C-C motif)-like), member A1 : upregulated by infection of astrocytes Ramesh et al, 2008
  85. FAS Fas cell surface death receptor: . B.burgdorferi increases Fas expression on CD3+ T lymphocytes Grygorczuk et al, 2010
  86. FASLG Fas ligand (TNF superfamily, member 6): deficiency impairs host inflammatory response against infection with the spirochete Shi et al, 2006.
  87. FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide : Increased pathogen burden in knockout mice Belperron et al, 2014
  88. FMNL1 – formin-like 1: regulates phagocytosis of Borrelia burgdorferi by human macrophages Naj et al, 2013.
  89. FN1 – fibronectin 1: binds to Borrelia spirochaetes Probert & Johnson, 1998
  90. galactocerebroside: adheres to the spirochete: a glycolipid component of myelin that could act as a receptor for B. burgdorferi in oligodendroglia and in Schwann cells Garcia-Monco & Benach, 1997
    1. Also binds to glucosylceramide and lactosylceramide Masuzawa, 1997
  91. FSTL1 follistatin-like 1: induced by B. burgdorferi infection and required for the development of Lyme arthritis in mice Campfield et al, 2014
  92. Glycosaminoglycans : Borrelia adhesins and others bind to glycosaminoglycans: Lin et al, 2014 including heparan sulfate, heparin chondroitin sulfate and dermatan sulfate Parveen et al, 1999 Fischer et al, 2003 Glycosaminoglycans are in turn bound to diverse proeoglycan receptors (Decorin , biglycan, brevican, testican, syndecan, bikunin, fibromodulin, lumican, aggrecan, versican, neurocan, perlecan et al ) although the relationship of each to Borrelia binding remains to be tested) See Wikipedia
  93. Glycosphingolipids: Live Borrelia burgdorferi binds to to galactocerebroside, lactosylceramide, and ceramide trihexoside and to the disialoganglioside GD1a and the trisialoganglioside GT1b but not to gangliosides GM1, GD1b, GM2, and GM3 and not to asialo GM1 Backenson et al, 1995.
  94. HAMP hepcidin antimicrobial peptide: intact and sonicated B burgdorferi induced hepcidin expression in cultured mouse bone marrrow macrophages Koening et al, 2009
  95. Histamine : Spirochetes and spirochetal sonicates release histamine from basophils Benach et al, 1986
  96. HLA-DRB1 Treatment-resistant Lyme arthritis is associated with immune reactivity to outer surface protein A (OspA) of Borrelia burgdorferi, the agent of Lyme disease, and the major histocompatibility complex class II allele DRB1*0401 Gross et al, 1998.
  97. HLA-DRB5: DRB1*0401, 0101, 0404, 0405, DRB5*0101, DRB1*0402, and 0102) showed strong to weak binding of the Borrelia peptide OspA163-175 Steere et al, 2006
  98. HSPD1 heat shock 60kDa protein 1 (chaperonin): Molecular mimicry: Antibodies to the spirochete flagellin cross react with HSPD1 Dai et al, 1993
  99. ICAM1 intercellular adhesion molecule 1: induced by exposing chondrocytes to Borrelia protein BbHtrA in vitro Russell et al, 2013
  100. ICAM2 intercellular adhesion molecule 2 :ICAM2 and VCAM1 upregulated and NCAM1 mRNA downregulated by the Geho strain of spirochete in synovial cells Singh et al, 2006
  101. IDO1 indoleamine 2,3-dioxygenase 1: activated by infection in immune cells Love et al, 2014
  102. IFNA1 – interferon, alpha 1: human PBMCs initiate a type I IFN response to B. burgdorferi via TLR7 and 9, inducing IFNA1,IFNB1 and IRF7 Petzke et al, 2009
  103. IFNB1 – interferon, beta 1, fibroblast: human PBMCs initiate a type I IFN response to B. burgdorferi via TLR7 and 9, inducing IFNA1,IFNB1 and IRF7 Petzke et al, 2009
  104. IFNG – interferon, gamma: Different spirochaete strains variably upregulate IFNG production Anguita et al, 2001
  105. IFNL1 interferon, lambda 1: Released from peripheral blood cells by the spirochete Krupna-Gaylord et al, 2014
  106. IFNAR1 interferon (alpha, beta and omega) receptor 1: Bone marrow-derived macrophages induce IFN-responsive genes following B. burgdorferi stimulation, and this expression required a functional type I IFN receptor Miller et al, 2008
  107. IFNGR1 – interferon gamma receptor 1: administration of B. burgdorferi-immune sera to IFN-gammaR-deficient mice infected with B. burgdorferi N40 causes spirochete clearance Anguita et al, 2001.
  108. IL1B – interleukin 1, beta: activated by infection in human peripheral blood mononuclear cells Miller et al, 1992
  109. IL1RN – interleukin 1 receptor antagonist: reduces the IL1B, LPS-, and B. burgdorferi-induced IL8 synthesis in human peripheral blood mononuclear cells Porat et al, 1992
  110. IL2 Interleukin 2: IFNG and IL2 stimulated by the spirochete in Borrelia burgdorferi -specific T cell lines Pride et al, 1998
  111. IL2RA interleukin 2 receptor, alpha : T cell activation markers CD25 (IL2RA) , CD69 and CD71 (TFRC) induced by B.Burgdorferi outer surface protein C Salazar et al, 2005
  112. IL4 interleukin 4: regulates spirochete growth Keane-Myers and Nickell, 1995
  113. IL5 Interleukin 5: suppression of both IL-4 and IL-5 prior to the feeding of B. burgdorferi-infected ticks significantly decreased spirochete load in target organs such as joint, bladder, heart, and skin of the Lyme disease-susceptible host Zeidner et al, 2008.
  114. IL6 interleukin 6 (interferon, beta 2): TLR1, TLR2 and MYD88 involved in IL6, IL8, and TNF-alpha increases induced by B.Burgdorferi in human monocytes Dennis et al, 2009
  115. IL8 interleukin 8: TLR1, TLR2 and MYD88 involved in IL6, IL8, and TNF-alpha increases induced by B.Burgdorferi in human monocytes Dennis et al, 2009
  116. IL9 Interleukin 9: Stimulated by the spirochete in macrophages Gautam et al, 2011
  117. IL10 Interleukin 10: Induction of pro- and anti-inflammatory cytokines (IL1B, IL6, IL10) by Borrelia burgdorferi lipoproteins in monocytes is mediated by CD14 Giambartolomei et al, 1999.
  118. IL12 Interleukin 12 ( heterodimer of IL12A and IL12B) stimulation of PBMC with live Borrelia, increases the production of IL-12 and IFN-gamma, IL1B, TNF, IL6 and IL10 Janský et al, 2003.
  119. IL17A interleukin 17A : Borrelia species induce inflammasome activation and IL17 production via caspase-1-Oosting et al, 2011.
  120. IL18 Interleukin 18: generated in response to live spirochetes in peripheral blood mononuclear cells Salazar et al, 2009.
  121. IL22 interleukin 22 : secreted by peripheral blood mononuclear cells exposed to live Borrelia burgdorferi Bachmann et al, 2010
  122. IL23 Interleukin 23: (heterodimer of IL23A and IL12B) Borrelia NapA protein induces the expression of IL23 in neutrophils and monocytes, and the expression of IL6, IL1B, and transforming growth factor beta (TGF-ß) in monocytes, via TLR2 Codolo et al, 2010.
  123. IRAK4 interleukin-1 receptor-associated kinase 4: Cytokine response to purified borrelia burgdorferi RNA is mpaired in human monocytes naturally deficient in IRAK-4 Cervantes et al, 2013
  124. IRF3 interferon regulatory factor 3: induced by sonicated bacteria, by the lipoprotein OspA, and by factors released into the medium during culture of B. burgdorferi Miller et al, 2010.
  125. IRF7 – interferon regulatory factor 7: human PBMCs initiate a type I IFN response to B. burgdorferi via TLR7 and 9, inducing IFNA1,IFNB1 and IRF7 Petzke et al, 2009
  126. ITGA2B – integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41): B. burgdorferi binding to human platelets is mediated by ITGA2B/ITGB3 Coburn et al, 1993
  127. ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor): BB0172, a Borrelia burgdorferi outer membrane protein binds integrin a3ß1 Wood et al, 2013.
  128. ITGA5 – integrin, alpha 5 (fibronectin receptor, alpha polypeptide): B. burgdorferi recognizes ITGA5/ITGB3and ITGA5/ITGB1 Coburn et al, 1998
  129. ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) : deficiency associated with heightened heart B. burgdorferi burden relative to wild type mice Guerau-de-Arellano et al, 2005.
  130. ITGAM – integrin, alpha M (complement component 3 receptor 3 subunit): ITGAM/ITGB2 acts as a receptor for spirochetes in nonimmune phagocytosis Cinco et al, 1997
  131. ITGAX integrin, alpha X (complement component 3 receptor 4 subunit; CD11c ): ITGAX knockout mice, but not ITGAM-/- mice, developed aggravated Lyme carditis after exposure to B. burgdorferi Guerau-de-Arellano et al, 2005.
  132. ITGB1 – integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12): B. burgdorferi recognizes ITGA5/ITGB3and ITGA5/ITGB1 Coburn et al, 1998
  133. ITGB2 – integrin, beta 2 (complement component 3 receptor 3 and 4 subunit): ITGAM/ITGB2 acts as a receptor for spirochetes in nonimmune phagocytosis Cinco et al, 1997
  134. ITGB3 – integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) : B. burgdorferi binding to human platelets is mediated by ITGA2B/ITGB3 Coburn et al, 1993
  135. JAK3 Janus kinase 3: Inhibition prevents effects of the spirochete on metalloprotease activity Behera et al, 2004.
  136. KIR2DL3 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3 : upregulated by infection of astrocytes Ramesh et al, 2008
  137. LBP lipopolysaccharide binding protein : LBP or soluble CD14 sensitizes TLR-expressing cells to nanogram levels of a synthetic lipopeptide or the Borrelia OspA lipoprotein agonist Ranoa et al, 2013
  138. MAPK1 mitogen-activated protein kinase 1: activated by Borrelia lipoproteins in astrocytes Ramesh and Philipp, 2005.
  139. MAPK3 mitogen-activated protein kinase 3: activated by Borrelia lipoproteins in astrocytes Ramesh and Philipp, 2005.
  140. MAPK8 mitogen-activated protein kinase 8 (JNK): controls TNF production and TLR-mediated macrophage responses to Borrelia burgdorferi Izadi et al, 2007
  141. MAP2K1 mitogen-activated protein kinase kinase 1: Involved in the spirochete indiced secretion of IL8 from macrophage-like THP-1 cells Sadik et al, 2008
  142. MAP2K3 mitogen-activated protein kinase kinase 3 (MKK3) Mice deficient for MKK3 develop a lower Th1 response and exhibit an impaired ability to produce proinflammatory cytokines upon infection with the spirochete Hedrick et al, 2006
  143. MAPK14 – mitogen-activated protein kinase 14: regulates activation of NF-kappaB in response to spirochetal lysate stimulation of phagocytic cells Olson et al, 2007
  144. MAPT – microtubule-associated protein tau: Borrelia burgdorferi spirochetes and LPS induce beta-amyloid deposition and tau phosphorylation in mammalian glial and neuronal cells in vitro Miklossy et al, 2006
  145. MARCO macrophage receptor with collagenous structure: involved in Borrelia phagocytosis by bone marrow-derived macrophages Petnicki-Ocwieja et al, 2013
  146. MIR146A microRNA 146a: Peritoneal macrophages from B6 miR-146a-/- mice show enhanced phagocytosis of B. burgdorferi Lochhead et al, 2014.
  147. MME membrane metallo-endopeptidase (CD10 / neprilysin) : Picomolar concentrations of OspA induce surface markers associated with neutrophil activation: increased MME and ITGAM (CD11b) expression and decreased Selectin L expression Morrison et al, 1997
  148. MMP1 – matrix metallopeptidase 1 (interstitial collagenase): induced in chondrocyte cultures infected with Borrelia burgdorferi Lin et al, 2001
  149. MMP3 – matrix metallopeptidase 3 (stromelysin 1, progelatinase): induced in chondrocyte cultures infected with Borrelia burgdorferi Lin et al, 2001
  150. MMP9 – matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase): secretion induced via TLR2 in human and murine monocytic cells stimulated with Borrelia burgdorferi Gebbia et al, 2004.
  151. MMP13 matrix metallopeptidase 13 (collagenase 3) : B. burgdorferi infection induces MMP-1, -3, -13, and -19 transcription from primary human chondrocyte cells Behera et al, 2005
  152. MMP19 matrix metallopeptidase 19: B. burgdorferi infection induces MMP-1, -3, -13, and -19 transcription from primary human chondrocyte cells Behera et al, 2005
  153. MRC1 mannose receptor, C type 1: adheres to the spirochaete in monocyte-derived macrophages Cinco et al, 2001
  154. MX1 myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 : IFN-a protein and IRF7, MX1, and OAS1 transcripts induced by endosomal delivery of B. burgdorferi DNA, RNA, or whole-cell lysate in human peripheral blood mononuclear cells Love et al, 2014
  155. MYD88 myeloid differentiation primary response 88: TLR1, TLR2 and MYD88 involved in IL6, IL8, and TNF-alpha increases induced by B.Burgdorferi in human monocytes Dennis et al, 2009
  156. NCAM1 neural cell adhesion molecule 1: ICAM2 and VCAM1 upregulated and NCAM1 mRNA downregulated by the Geho strain of spirochete in synovial cells Singh et al, 2006
  157. NCAN Neurocan: degraded by a Borrelia protease Russell and Johnson, 2013
  158. NFKB1 – nuclear factor of kappa light polypeptide gene enhancer in B-cells 1: activated in response to spirochetal lysate stimulation of phagocytic cells Olson et al, 2007
  159. NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha : Induced by spirochete infection in mouse macrophages Gautam et al, 2012
  160. NOD2 – nucleotide-binding oligomerization domain containing 2: Upregulated by the spirochete in astrocytes Sterka et al, 2006
  161. NOS2 nitric oxide synthase 2, inducible: borrelia increased NOS2 expression in Kupffer cells that peaked at 6 hours and was still evident 22 h after infection Marangoni et al, 2006.
  162. OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa : IFN-a protein and IRF7, MX1, and OAS1 transcripts induced by endosomal delivery of B. burgdorferi DNA, RNA, or whole-cell lysate in human peripheral blood mononuclear cells Love et al, 2014
  163. P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6 : upregulated by infection of astrocytes Ramesh et al, 2008
  164. PECAM1 platelet/endothelial cell adhesion molecule 1: Expression increased dowmstream of Borrelia activation of CD40 Pulzova et al, 2011
  165. PLAU – plasminogen activator, urokinase: stimulation of monocytic cells with B. burgdorferi induces production and secretion of PLAU , shortly followed by its physiological inhibitor, plasminogen activator inhibitor-2 (SERPINB2) Haile et al, 2006.
  166. PLAUR – plasminogen activator, urokinase receptor : Expression and release stimulated by the spirochaete in monocytes Coleman et al, 2001
  167. PLG – plasminogen: B. burgdorferi binds human plasmin(ogen)-via its outer cell surface lipoprotein A Fuchs et al, 1994
    1. plasmin-coated B. burgdorferi degrades fibronectin, laminin, and vitronectin Coleman et al, 1999
  168. PTGER2 – prostaglandin E receptor 2 (subtype EP2), 53kDa: B. burgdorferi induces mRNA and protein expression of PTGER2 and PTGER4 in murine microglia Rasley et al, 2004
  169. PTGER4 – prostaglandin E receptor 4 (subtype EP4): B. burgdorferi induces mRNA and protein expression of PTGER2 and PTGER4 in murine microglia Rasley et al, 2004
  170. PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) up-regulated in murine B cells by B. burgdorferi Blaho et al, 2009
  171. PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) : up-regulated in murine B cells by B. burgdorferi Blaho et al, 2009
  172. Purines: The spirochete lacks the enzymes required for de novo synthesis of purines and depends on host purines and pyrimidines for DNA and RNA synthesis: It encodes transporters for hypoxanthine, adenine, and guanine Jain et al, 2012
  173. PYCARD PYD and CARD domain containing (ASC): PYCARD/caspase-1-driven IL1B is crucial for induction of B. burgdorferi-induced murine Lyme arthritis Oosting et al, 2012
  174. Quinolinic acid: CSF levels significantly elevated in B burgdorferi infection Halperin & Heyes, 1992
  175. RAC1 as-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1): phagocytosis of Borrelia burgdorferi by primary human macrophages is controlled by CDC42 and Rac1 and involves recruitment of Wiskott-Aldrich syndrome protein and the Arp2/3 complex Linder et al, 2001
  176. RELA – v-rel avian reticuloendotheliosis viral oncogene homolog A: Phosphorylation increased by B. burgdorferi lysates in phagocytic cells Olson et al, 2007
  177. RPS6KA5 – ribosomal protein S6 kinase, 90kDa, polypeptide 5: siRNA repression results in reduced RelA phosphorylation and a decrease in TNF production in response to B. burgdorferi lysates in phagocytic cells Olson et al, 2007.
  178. S100A8 S100 calcium binding protein A8: Calprotectin (S100A8+S100A9) inhibits the growth of spirochetes through chelation of the essential cation, Zinc Lusitani et al, 2003.
  179. SELE – selectin E: expression increased by infection in endothelial cells Burns et al, 1997
  180. SELL selectin L: Picomolar concentrations of OspA induce surface markers associated with neutrophil activation: increased MME and ITGAM (CD11b) expression and decreased Selectin L expression Morrison et al, 1997
  181. SERPINB2 – serpin peptidase inhibitor, clade B (ovalbumin), member 2: stimulation of monocytic cells with B. burgdorferi induces production and secretion of PLAU , shortly followed by its physiological inhibitor, plasminogen activator inhibitor-2 (SERPINB2) Haile et al, 2006.
  182. SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1: Inhibits Borrelia burgdorferi-bound fibrinolytic enzymes Perides et al, 1996
  183. SERPINF2 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2: Inhibits Borrelia burgdorferi-bound fibrinolytic enzymes Perides et al, 1996
  184. SOCS1 suppressor of cytokine signaling 1 : B. burgdorferi or lipidated outer surface protein A (L-OspA) increase their SOCS1/SOCS3 mRNA and protein expression in mouse J774 macrophages incubated with IL-10 Dennis et al, 2006
  185. SOCS3 suppressor of cytokine signaling 3 : See above Dennis et al, 2006
  186. SRC SRC proto-oncogene, non-receptor tyrosine kinase: Required for cellular invasion Wu et al, 2011
  187. STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) B. burgdorferi infection induces phosphorylation and nuclear translocation of STAT3 and STAT6 in primary human chondrocytes Behera et al, 2004.
  188. STAT6 signal transducer and activator of transcription 6, interleukin-4 induced: B. burgdorferi infection induces phosphorylation and nuclear translocation of STAT3 and STAT6 in primary human chondrocytes Behera et al, 2004.
  189. TAC1 – tachykinin, precursor 1: substance P augments B. burgdorferi-induced mRNA and protein expression of PTGER2 and PTGER4 in murine microglia Rasley et al, 2004
  190. TACR1 tachykinin receptor 1 (expressed on microglia) : elevations in inflammatory cytokine production and decreases in the production of an immunosuppressive cytokine, in response to Neisseria meningitidis or Borrelia burgdorferi are attenuated in mice genetically deficient in the expression of the TACR1 or in mice treated with a specific TACR1antagonist Chauhan et al, 2008
  191. TF transferrin: an outer membrane protein (28 kDa) from B. burgdorferi B31 binds transferrin Carroll et al, 1996
  192. TFRC transferrin receptor: T cell activation markers CD25 (IL2RA) , CD69 and CD71 (TFRC) induced by B.Burgdorferi outer surface protein C Salazar et al, 2005
  193. TGFB1 transforming growth factor, beta 1: Borrelia NapA induces the expression of IL23 in neutrophils and monocytes, as well as the expression of IL6, IL1ß, and TGFB1 in monocytes, via TLR2 Codolo et al, 2010
  194. TICAM1 – toll-like receptor adaptor molecule 1: mediates Toll-like receptor 2-dependent inflammatory responses to Borrelia burgdorferi. Petnicki-Ocwieja et al, 2013
  195. TICAM2 toll-like receptor adaptor molecule 2: Induced by spirochete infection in mouse macrophages Gautam et al, 2012
  196. TLR1 toll-like receptor 1, TLR1, TLR2 and MYD88 involved in IL6, IL8, and TNF-alpha increases induced by B.Burgdorferi in human monocytes Dennis et al, 200 phagocytosis of B. burgdorferi by microglia enhances the expression of TLR1, -2, -4and -5 Bernardino et al, 2008.
  197. TLR2 toll-like receptor 2: TLR1, TLR2 and MYD88 involved in IL6, IL8, and TNF-alpha increases induced by B.Burgdorferi in human monocytes Dennis et al, 2009
  198. TLR3 toll-like receptor 3: B. burgdorferi activation of MyD88 or TLR3/TRIF signaling resulted in increased activity of AKT1 and PI3K in bone marrow derived macrophages Shin et al, 2009.
  199. TLR4 toll-like receptor 4: phagocytosis of B. burgdorferi by microglia enhances the expression of TLR1, -2, -4and -5 Bernardino et al, 2008.
  200. TLR5 – toll-like receptor 5: downregulated by Borrelia lipoproteins in human monocytes. Cabral et al, 2006
  201. TLR6– toll-like receptor 6: functional interaction between TLR2 and TLR6 in the cellular response to Borrelia OspA-L in human dermal endothelial cells Bulut et al, 2001
  202. TLR7 – toll-like receptor 7: human PBMCs initiate a type I IFN response to B. burgdorferi via TLR7 and 9 Petzke et al, 2009
  203. TLR8 toll-like receptor 8 : Intracellular receptors TLR7, TLR8 and TLR9 and the NLR receptor NOD2 represent a major recognition system of Borrelia Oosting et al, 2014.
  204. TLR9 – toll-like receptor 9: human PBMCs initiate a type I IFN response to B. burgdorferi via TLR7 and 9 Petzke et al, 2009
  205. TNF tumor necrosis factor: TLR1, TLR2 and MYD88 involved in IL6, IL8, and TNF-alpha increases induced by B.Burgdorferi in human monocytes Dennis et al, 2009
  206. TNFAIP3 tumor necrosis factor, alpha-induced protein 3 : : Induced by spirochete infection in mouse macrophages Gautam et al, 2012
  207. TOLLIP toll interacting protein: involved in toll receptor responses to spirochete ligands in human dermal endothelial cells Bullut et al, 2001
  208. TP53 tumor protein p53: B. burgdorferi increases p53 protein levels in a human oligodendrocyte cell line Parthasarathy and Philipp , 2014
  209. TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase: known target of miR-146a involved in NF-KB activation, dysregulated in resting and B. burgdorferi-stimulated B6 miR-146a-/- macrophages, and related to elevated IL1B, IL6 and CXCL1 production Lochhead et al, 2014
  210. VCAM1 vascular cell adhesion molecule 1 : ICAM2 and VCAM1 upregulated and NCAM1 mRNA downregulated by the Geho strain of spirochete in synovial cells Singh et al, 2006
  211. VCAN Versican: degraded by a Borrelia protease Russell and Johnson, 2013
  212. VEGFA vascular endothelial growth factor A : found at increased levels at the site of inoculation of B. burgdorferi in skin Antonara et al, 2010
  213. VSIG4 V-set and immunoglobulin domain containing 4: Expression modified by B.Burgdorferi but not B. afzelii or B. garinii in fibroblasts Geca et al, 2012
  214. VTN Vitronectin: plasmin-coated B. burgdorferi degrades fibronectin, laminin, and vitronectin Coleman et al, 1999
  215. WAS Wiskott-Aldrich syndrome: phagocytosis of Borrelia burgdorferi by primary human macrophages is controlled by CDC42 and Rac1 and involves recruitment of Wiskott-Aldrich syndrome protein and the Arp2/3 complex Linder et al, 2001

 

Bulk experiments

Interleukin-10 alters effector functions of multiple genes induced by Borrelia burgdorferi in macrophages to regulate Lyme disease inflammation Gautam et al, 2011.

Selected upregulated gene transcripts in macrophages 4 h after exposure to live B. burgdorferi which were downregulated in the presence of added exogenous IL-10:

ACSL1 ARHGEF3 ARL5C C3 CARD15 CCL2 CCL5 CD83 CDC42EP2 CFLAR CISH COX17 CSF1 CXCL10 CXCL2 CYBB DENR DTX4 EGR2 EIF5 GADD45B GBP2 GPR109A HIVEP3 ICAM1 IFRD1 IL6 IRAK2 JAG1 JUNB MAFF MALT1 MARCO MSR1 NAF1 NFKB1 NFKBIE NR4A1 PARP14 PLK2 PNRC1 PPFIBP2 PTPRI PVR SDC4 SLC11A2 STX11 TLR2 TNF TRAF1 URAH ZC3H12A

Selected upregulated gene transcripts in macrophages 4 h after exposure to live B. burgdorferi which were potentiated in the presence of added exogenous IL-10

1200016E24RIK 1810022K09RIK 5730508B09RIK ADAMTS1 ADORA2B ARC ATF3 BCL3 CAR13 CASP1 CCL4 CCL9 CCRN4L CD40 DGAT2 DUSP1 E2F5 FCGR2B FCGR3 HCK HIF1A IER3 IKBKE IL10 IL1B IL1RN KLF7 MAP4K4 MCOLN2 MESDC1 MGEA6 MITF MMP13 MRPL52 MXD1 NDRG1 NFE2L2 NFIL3 PDE4B PIK3R5 PIM1 PIM3 PLEK PTGS2 RAB12 RGL1 RNF149 SAA1 SAA3 SAMSN1 SDE2 SLC16A1 SOD2 STAT3 SUSD6 SYT10 TET2 TMA16 TMEM23 TNFAIP3 TNFRSF9 TNIP3 UGCG ZFAND5

Selected upregulated gene transcripts in macrophages 24 h after exposure to live Borrelia burgdorferi which were potentiated in the presence of added exogenous IL-10

5730508B09RIK ARHGEF3 BCL3 BSTI CCL12 CCL2 CCL4 CCL7 CCL9 CCRN4L CD244 CHPF CLEC4A2 CLEC4A3 CLEC4B1 CSF2RB1 D3UCLA1 DRAM1 DUSP2 ENSMUST00000094405 FCGR1 FOS FPR1 FRAG1 GLRX HTRA1 IFITM2 IL1B IL4RA LCN2 LRRC25 MARCKS MDM4 MMP13 MRPL52 NFKBIA P4HB PDE4B PTPRJ RGL1 RHOQ RNF149 SAA1 SDC4 SLC28A2 TMEM176B URAH WFDC17ZFP36

Selected upregulated gene transcripts in macrophages 24 h after exposure to live Borrelia burgdorferi which were downregulated in the presence of added exogenous IL-10

ARL5C ASS1 BIRC3 BST2 C3 CAR13 CCDC50 CCL5 CD40 CD47 CDC42EP2 CLEC4E CP CRYM CXCL2 CYB5B CYBB DGAT2 DGKH DHX58 EHD1 ELL2 EMR1 ENSMUST00000073378 FABP4 FAS GBP4 GPR84 IER3 IFI202B IRAK3 IRF7 IRG1 ISG15 LCP2 MARCO MMP9 MS4A11 MS4A6B MS4A6C MS4A6D NR4A1 OAS1A OAS2 PPFIBP2 PTGS2 RAB32 RASA4 RASSF4 SAA3 SH3BP5 SLC11A2 SLC31A2 SLPI SOD2 SP100 SYK TLR1 TLR2 TNF TNFAIP3 TRAF1 USP18 WNT6 ZC3H12C

Microarray Analyses of Inflammation Response of Human Dermal Fibroblasts to Different Strains of Borrelia burgdorferi Sensu Stricto PlosOne Schramm et al, 2012

Upregulated genes

ADAM17 BASP1 BIRC3 CFLAR COL8A1 CXCL1 CYP1B1 DNAJA1 FGF7 GJA1 HIF1A IFIH1 IKBA IL12A IL13 IL15 IL3 IL6 IL8 IL9 IRF1 ITGA1 JUN LAMA1 LOC387763 MFAP3 MMP1 MMP12 MMP3 NBN NFKB1 NFKB2 NNMT OAS2 PTX3 REL RELB SNCA SOCS1 SOCS5 SOD2 STAT1 STAT2 TNFRSF6 TNFSF10

Downregulated genes:-

ABCB6 ACTG2 ADH1C AGT ANXA2 APC ASAH2 ASB3 BAP1 BGLAP CAPG CAT CERCAM CKAP5 CKB CLU CNN2 CORO1B CORO1C CORO2A CPE CRAT CRYAB DPT EGR1 EPHX2 EXOSC10 FABP5 FAM129B FASN FBN2 FER1L3 FKBP1B FUCA1 FUT1 G6PD GGT2 GOT1 GSTM1 H6PD HOPX HOXD10 HSPA4 HSPA4L HSPB2 HSPB3 ITGA3 ITGA4 ITGA6 KRT86 LEFTY2 LTBP2 LTBP4 MAGEB1 MAZ MFAP5 MFI2 MGST2 MMP16 MTA1 NAB2 NDUFA3 NME3 NR1D1 NUDT1 ODC1 PFDN1 PGHD PKBP38 PLAC9 POLD1 POLD4 PPIE PPIH PPP2R1A PPPR31 PRKCZ RBM3 SLC20A1 SLIT3 STMN1 SULT1E1 TAGLN TFDP1 TK1 TOP1 TRAP1 TSGA14 TUBA1B TYMS UPA VGLL3

The Borrelia burgdorferi integrin ligand P66 affects gene expression by human cells in culture. LaFrance et al, 2011

Selected Genes belonging to significantly differentially expressed KEGG pathways in Ea.hy926 cells infected with p66+ versus delta p66 B. burgdorferi bacteria

ACTB ACTN4 ARHGEF1 CACNB3 CACNG1 CACNG4 CACNG5 CEACAM1 F2RL3 GSN HSPA1A IL11RA MAPK14 MAPK8 MYL6 NOS2 PIK3CG PIK3R2 PIK3R3 PLA2G2 PLA2G5 PPP1R12 PRKCB1 PTK2 RAC1 RAPGEF2 ROCK1 STAT1 STAT4 STAT6 TAOK2 TNIP1 VAV2

Genes significantly differentially expressed in 293 and 293+avß3 cells infected with p66+ versus delta p66 bacteria

ACTB ALG14 COL11A1 COLL5A1 COLL9A1 CTNNB1 EMID2 ERK5 FGFR2 HAPLN3 JAK2 LAMA4 MAN1A2 MAP3K5 MGAT1 PCDHB4 PPP1CB SCYE1 SOS1 STAT5B THBS2 TLN1 TNFSF11 ULBP1 VAV2

Microglia are mediators of Borrelia burgdorferi-induced apoptosis in SH-SY5Y neuronal cells. Myers et al, 2009 Molecules associated with TREM1 signaling in microglia co-cultured in the presence of B. burgdorferi for 5 days.

Upregulated:- CASP1 CCL2 CCL7 CD40 CD86 CSF2 FCGR2B ICAM1 IL6 IL8 IL18 ITGB1 JAK2 NFKB1 NFKB2 NOD2 TLR2 TNF TREM1 Downregulated:- IL10 PLCG2 TLR8

SY cells co-cultured with B.burgdorferi

UP: AKT1 GADD45B CDKN2A DRAM Down: ATM BCL2 BCL2L1 HIPK2 MED1THBS1

SY cells co-cultured with B.burgdorferi and microglia:-

UP: AKT1 BCL2L1 CDK2 CDKN1A CDKN2A FASN PTEN Down: AKT3 BAX GSK3B MAPK14 PMAIP1

IFN-gamma alters the response of Borrelia burgdorferi-activated endothelium to favor chronic inflammation Dame et al, 2007

Upregulated (Borrelia alone)

ADCY6 AGTRAP ALDH2 ALG8 ALKBH4 ANAPC1 ANAPC4 ANKRD40 APIP AQR ARHGAP1 ARHGAP11A ARHGAP19 ARMC7 ASB18 ASB8 ATP5F1 BAZ1B BET1 BLVRB BTD C19orf2 CASP8 CD300LD CDK2AP1 CEP76 CIAO1 CKAP5 CLEC10A CLYBL CMC1 CNIH4 COG4 CPNE3 CRAT CRYGS CUL4A DARS DCAF7 DCP2 DEXI DGCR8 DIRAS2 DNA2 DPAGT1 EAPP ELMOD2 ERAP1 FAM195A FAM199X FBXO21 FBXO4 FBXW8 FGFR1OP2 FIBP FPGS FUT4 GALNT4 GDF3 GGH GNS GPAA1 GPAT2 GPR179 GPR52 GPSM2 GTF3C5 HDGF HIST1H2AC HPS3 HS6ST1 HTR1D IL12A IL1R1 IL20RA IMPA1 IRF2BP1 JPH1 KCNK12 KLHDC8B KLHL36 KLHL4 LCOR LCORL LHX1 LRIG2 LTA4H LYPLA1 MAP3K13 MBNL3 MCCC2 MRPL1 MRPL35 MRPL51 MRPS33 MRS2 MYL4 NDUFB4 NEDD1 NME4 NUDT16 NUDT7 OGFOD1 OSGEPL1 OTUB2 PARD6B PARN PARS2 PAXIP1 PCYOX1 PDCD6IP PELP1 PGD PGP PHB2 PLDN POLDIP2 POLE2 POU6F2 PPA2 PPP1R7 PPP3CB PRR5 QDPR RAB9B RGS18 RNASEL RWDD2B S100A1 SACM1L SESN1 SIGMAR1 SLC35A5 SNCA SRI STX18 SUFU TGDS TMCO1 TMEM179 TMEM209 TMX4 TRAM1 TRAT1 TYW1 USP46 WARS WDR12 WDR67 WDSUB1 WIPI1 XPO1 XRCC5

Downregulated (Borrelia alone)

ACSBG1 ADIG ADRM1 ANKRD56 APLN ARID5A ARL5B ATF3 ATG16L2 C16orf80 CABP1 CCDC121 CCDC9 CCNL1 CCNL2 CD274 CD3EAP CDK12 CHD2 CLDN3 CLK4 COTL1 CTLA4 CTSL1P3 CUBN CXCR4 CYLC2 CYP27B1 DDX50 DLX3 DMTF1 DNAJC12 DTNBP1 DUSP3 DUSP4 EGR4 ETS2 ETV3 F10 FAHD1 FZD3 GADD45B GCH1 GHITM GK5 GLUD1 GNG4 GPER GPR132 GPR183 GPR4 GPX2 GRB7 GSPT2 HFM1 HIP1R HSP90AA1 IER5 IER5L IFNA5 ING3 IRS2 ISG15 ISG20 ITSN1 KDM6B KLHL2 KLRC2 KRT15 LHX3 LONRF3 LRRC15 MAFG MAFK MC3R MED11 MEF2D METTL6 MST1R MUC1 MYO6 NACA NDUFS5 NEK8 NFKBIA NFKBIE NKX2-5 NLE1 NNAT NPNT NR1D2 NR4A2 NRG3 NXF1 OMG PER1 PFKP PLAUR PLD5 PLK2 PNRC1 PPP1R11 PQBP1 PRKCSH PRPF6 PRSS46 PRTG PSD PVR PWWP2B RAMP2 RGS9 RGS9BP RNF183 RORA RPL4 RPS19BP1 SCEL SCN3A SCN4B SERTAD1 SERTAD4 SF1 SFTPB SHISA6 SLC2A5 SLC3A2 SORCS1 SQSTM1 TDP2 TEX14 TGIF1 TINF2 TMEM63B TNFAIP3 TNFRSF10B TPD52L2 TRA2B UBC VPS37B VSTM2L WNK1 ZC3H11A ZCCHC14 ZFAND2A ZFC3H1

Interleukin-10 Alters Effector Functions of Multiple Genes Induced by Borrelia burgdorferi in Macrophages To Regulate Lyme Disease Inflammation Gautam et al, 2011

Modified genes AARS AATK ABCA8B ABCC5 ABCG1 ABI1 ABI2 ABI3 ABO ABPB ACOD1 ACOT7 ACP2 ACSL1 ACTA2 ACTG2 ADA ADAMTS4 ADCY7 ADCY9 ADFP ADH1 ADIPOQ ADRBK1 AFP AFP AHNAK AK2 AKAP13 ALDOB ALOX5 AMD2 AMICA1 ANGPT2 ANKH ANKLE1 ANKMY2 ANKRD37 ANKRD57 ANXA8 AOAH AP1S2 AP2B1 APBBL1P APOA1 APOC2 APOL2 APS32 ARHGAP11A ARHGAP12 ARHGAP25 ARHGAP6 ARHGEF10L ARHGEF40 ARHGEF6 ARID5A ARID5B ARL4C ARL4C ARL4D ARL5B ARRB1 ARRDC3 ARRDC4 ASAHL ASF1B ASF1B ATAD2 ATAD5 ATBF1 ATF7IP ATP13A2 ATP2A2 ATP2B1 ATP2C1 ATP6V1H ATPBD4 AURKA AURKB AURKB AXUD1 BAZ1A BCAT1 BCL11B BCL2 BCL2A1B BCL2A1B BCL2A1C BCL2L11 BIRC3 BIRC5 BLM BLNK BMP2K BRCA1 BRIP1 BRK1 BST1 BUB1 BUB1B BZW2 C15ORF23 CACNA2D CACNG2 CADM1 CALR CAPN11 CAR10 CAR2 CARD14 CASC5 CASP1 CASP2 CASP4 CASP4 CASP9 CATSPER2 CATSPERG2 CBWD1 CBX5 CBX8 CCAR1 CCDC86 CCDC92 CCDC93 CCL3 CCL3 CCL7 CCL8 CCNA2 CCNB1 CCNB2 CCND1 CCND1 CCNF CCRL2 CCRL2 CCSER1 CCT4 CD14 CD274 CD274 CD28 CD300LG CD300LG CD302 CD46 CD5 CD83 CD95 CDC20 CDC25B CDC25B CDC6 CDC6 CDCA2 CDCA3 CDCA5 CDCA7 CDCA8 CDK1 CDKN1A CDKN2C CDKN2C CDKN2C CDKN3 CDT1 CDX4 CEBPB CEBPB CEBPD CENPA CENPA CENPE CENPF CENPF CENPH CENPK CENPL CENPN CENPO CENPQ CEP55 CEP55 CFB CFLAR CGNL1 CHD2 CHMP4B CHST11 CHST3 CHST7 CHTF18 CIAS1 CK137956 CKAP2 CLCN5 CLCNKA CLDND1 CLEC10A CLEC10A CLEC4E CLEC4N CLEC7A CLIC4 CLN5 CNIH2 CNN3 CNOT10 CNR2 CPD CPD CPD CPNE8 CPT1A CPT1A CREB3L2 CREG2 CRIP2 CROCC CRSP6 CRYGD CSF2 CSF2RB2 CSF3R CSG2RB1 CSK1B CSK2 CSNK1A1 CSRP1 CSTB CTDSP2 CTH CTLA2A CTNNB1 CTSH CTSL CUL5 CX3CR1 CXCL4 CXCR3 CXCR3 CXCR4 CYNND2 CYP2B19 CYTIP2 DDIT3 DDT DDX24 DDX58 DEPDC1 DEPDC1B DEPDC1B DFNA5 DFNA5H DFNA5H DGKH DGKH DHFR DIAP2 DIP3B DNA2L DNAJC9 DND1 DOK2 DPEP2 DRAM1 DSCC1 DSCR1 DST DTL DTL DTX1 DUSP1 DUSP18 DUSP2 DUSP6 DUSP6 DUT E2F1 E2F2 E2F2 E2F7 E2F8 E2F8 EBI3 ECT2 EDN1 EDN1 EFR3B EGR2 EIF1A EIF2C4 EIF2C4 EIF4G2 EIF5 EIF5B ELL2 ELP4 EML4 EMR1 ENC1 ENDOD1 EP300 EPB4 EPHA4 EPIM ESD ESPL1 ETS2 ETV3 EVL EXO1 EXO3CL4 EYA3 EZH2 FABP4 FAM102B FAM13A FAM19A3 FAM20C FAM64A FANCA FANCA FANCI FAS FASTKD5 FBN1 FBXO27 FBXO39 FBXO5 FCGR2B FCGR3A FGD2 FIGLM1 FITM2 FLNB FMNL3 FNBP1L FOLR2 FOXM1 FOXM1 FOXP1 FPR FTH1 FUS FYB FYCO1 GABRB2 GADD45B GALNT14 GANC GAPDH GAS2L3 GAS5 GAS5 GAS6 GAS7 GATA5 GBE1 GBP1 GBP1 GBP2 GBP4 GCH1 GCH1 GDAP10 GDF15 GDF15 GGPS1 GGTA1 GH GIMAP5 GINM1 GJA1 GJA4 GLCCI1 GLCCI1 GLIS2 GLRX Gm6105 GMFG GMNN GMNN GNA12 GNA12 GNG11 GNG12 GNGT2 GPR162 GPR84 GPR85 GPR85 GPSM2 GPX7 GRN GSAP GSBS GSE1 GSG2 GSK3B GSN GSTA3 GTF2IRD1 GTLF3B GVIN1 GVIN1 GYS2 H1F0 H28 H2AFB3 H2AFV H2AFV H2AFX H3F3A HAL HAL HAVCR2 HCK HDAC5 HELLS HELZ2 HHEX HIP1 HIST1H1D HIST1H2A1 HIST1H2AD HIST1H2AE HIST1H2AE HIST2H2AC HIST3H2A HIST4H4 HIST4H4 HIST4H4 HIST4H4 HIST4H4 HISTIH1B HISTIH1C HISTIH1E HJURP HK2 HK2 HMGB1L1 HMGB2 HMGB3 HMGCR HMGN2P24 HMHA1 HMOX1 HMX2 HNRPA0 HNRPA2B1 HNT HOXB1 HOXD3 HRH2 HSD17B7 HSP90B1 HSPA4L HSPA5 HSPD1 HTRA1 ICAM1 ICOSL ID1 ID2 IDH3A IDO2 IER5L IFI204 IFI27 IFI44 IFIT1 IFIT1 IFITM2 IFITM5 IFRD1 IGH IGH-6 IGHM IGJ IGSF6 IGSF6 IKBKE IL12B IL17RD IL1A IL1RL1 IL1RN IL1RN IL20 IL3RA1 IL4RA IL6 IMPAD1 INCENP INPP5D INTS6 IQCE IQGAP3 IQSEC1 IRAK2 IRAK3 IRF2BP2 ITGA6 ITPR2 JAK2 JAK2 JMJD3 JSK1 JUNB JUNDM2 KBTBD11 KBTBD11 KCNA1 KCNAB2 KCNK16 KCNMB1 KCTD12 KIAA0101 KIAA0513 KIAA0513 KIAA0586 KIF11 KIF13B KIF14 KIF18A KIF18B KIF1A KIF1A KIF20A KIF20B KIF21B KIF22 KIF22 KIF23 KIF4A KIFC3 KIFC5C KITL KITLG KLC4 KPNA2 KPNA3 KRT78 KSR2 LAMC1 LARS2 LASS6 LBR LCK LCN6 LCP1 LDHA LDLRAP1 LGALS3BP LGALS9 LIG1 LILRB4 LIN54 LLPH LMAN1 LMBRD1 LMNB2 LMO4 LMO4 LNPEP LOCKD LPIN1 LPIN3 LRG1 LRMP LRRC18 LRRC25 LRRC54 LRRC8D LSP1 LSR LSR LYL1 LYN MACROD1 MAD2L1 MAF MAFF MAN2B1 MAP3K12 MAP3K8 MAPKAPK2 MAPRE2 MARCKSL1 MARCKSL1 MASTL MBD1 MBNL1 MCM10 MCM6 MCM7 MDM1 MED12L MED22 MED7 MEFV MELK MEX3B MFAP31 MFAP31 MFHAS1 MGST1 MGST3 MICAL1 MICAL1 MIER1 MIF MIF-PS3 MIPOL1 MITF MLLT11 MMAA MMD MMD MMS19L MNAB MND1 MOGAT1 MOS MPZL1 MRPL1 MS4A4C MS4A6D MS4A7 MSR1 MSRB2 MT1 MT2 MTMR14 MVM3 MVM6 MVP MYBL2 MYH14 MYNN MYO1E MYO1F MYO6 N4BP3 NAA25 NADK NANOS1 NCAPD2 NCAPD2 NCAPD3 NCAPG NCAPG2 NCAPH NCAPH2 NCK2 NCOA3 NCOA6IP NDST1 NEIL3 NEK2 NEK6 NES NETO1 NEURL1B NFIC NFKB1 NFKB2 NFKBIA NFKBIB NFKBIB NFKBIL2 NFKBIZ NFKBIZ NIMA NOL5 NOL5A NOLA1 NOS2 NOTCH2 NOTCH2 NR1H3 NRM NSL1 NSMCE4A NT5DC3 NTNG1 NUCKS1 NUF2 NUMA1 NUP188 NUSAP1 OAS1F OAS3 OASL1 OASL2 ODC1 ODF4 OFR1403 OLFR137 OLFR139 OLFR1416 OLFR195 OLFR201 OLFR22-PS1 OLFR284=1 OLFR430 OLFR476 OLFR491 OLFR619 OLFR678 OLFR711 OLFR955 OPCML OPHN1 OPN3 OSBPL3 OSBPL9 OSGIN1 OSGIN2 OSGIN2 OTUD1 P2RX7 P2RY10 P2RY2 P2RY5 PA2G4 PAF1 PAK2 PALD1 PAOX PAQR7 PARP14 PASK PBEF1 PBK PBN2 PBX1 PCAF PCDHB15 PCDHGA9 PCNA PCNT PDE10A PDIA6 PDPR PDXK PDZD4 PDZPH1 PFGFB PFKFB3 PFKFB3 PGAM1 PGK1 PGR PHF11 PHF11D PIGT PIK3R5 PILRA PILRB PILRB2 PIP5K1B PITPNC1 PLAGL2 PLAGL2 PLAU PLAUR PLAUR PLEKHA2 PLEKHG3 PLK1 PLSCR1 POLD1 POLE POT1B POU2F2 PPAP2A PPIL5 PPL PPM1H PPP4R2 PRC1 PRDM1 PRDX1 PRDX1 PRDX5 PREPL PRKCC PROCR PROCR PRPF40A PRR3 PRSS27 PSCDBP PSCDBP PSD3 PSMD10 PSMD11 PSME2B PSME2B PSRC1 PTBP2 PTCD12 PTCHD1 PTGER4 PTGER4 PTGS1 PTPN13 PTPN14 PTPN14 PTPN18 PTPRM PTPRO PTPRO PTTG1 PURG PVRL1 PVRL1 PVRL3 RAB10 RAB11FIP1 RAB11FIP1 RAB11FIP1 RAB19 RAB19 RAB20 RAB31 RAB32 RAB39 RAB44 RAC2 RAC3 RACGAP1 RAD21 RAD51 RAD51AP1 RAF1 RALGDS RALGDS RAP2A RAPGEF2 RAPGEF2 RASA3 RASGEF1B RASGRP3 RASGRP3 RASSF3 RASSF4 RBL1 RBM25 RBM48 RCBTB2 RCHY1 RCN3 RCSD1 RDM1 RELB RFC5 RFFL RGS12 RGS18 RGS2 RGS2 RHBDF2 RHOA RHOD RHOJ RHOQ RILPL2 RIN2 RIOK3 RIOK3 RIPK2 RKHD3 RNASE10 RNASE4 RND1 RND1 RND3 RND3 RNF139 RNF150 RPA1 RPA2 RRBP1 RRM2 RRS1 RSAD4 RTBDN RTF1 RTP4 RWDD4A S1PR1 SAMD4 SAMHD1 SAMSN1 SCD2 SCN4A SCUBE1 SECTM1 SEPT11 SERINC3 SERPINA3G SESN1 SETD5 SF3B1 SFPQ SFRS10 SFRS11 SGCG SGOL1 SGOL2 SGSH SGSH SH3PXD2A SHCBP1 SHH SIGLEC1 SKA1 SKA3 SLA SLAMF9 SLBP SLC11A1 SLC14A2 SLC15A3 SLC16A1 SLC16A3 SLC17A5 SLC25A24 SLC26A11 SLC26A4 SLC28A2 SLC2A1 SLC2A6 SLC2A6 SLC31A1 SLC31A2 SLC37A2 SLC37A3 SLC39A12 SLC40A1 SLC45A4 SLC7A11 SLC7A11 SLC7A7 SLC9A6 SLFN SLFN2 SLPI SMAD3 SMC2 SMC4 SMG5 SMIM3 SNAI2 SNX10 SNX2 SNX24 SNX25 SNX27 SNX7 SNX8 SOC24 SOCS1 SOCS3 SOCS3 SPATA20 SPATS1 SPC25 SPG5 SPN SPPL2C SPPL3 SPRRL1 SPRY1 SPRY2 SPRYD7 SQSTM1 SRD5A2L2 SRPR SSX2IP SSX9 ST15 ST8SIA4 ST8SIA4 STAP1 STARD8 STARD9 STCH STFA1 STK17B STK38L STMN1 STNO SUN2 SUSD3 SWAP70 SYNCRIP SYNJ2 T2BP TACC1 TAF9B TASP1 TBC1D14 TBC1D9B TCF19 TCF19 TCF7L2 TCOF1 TDP2 TERF1 TET2 TF TFDP2 TFRC TGFB3 TGFB3 TGFBR2 THBD THOC2 TIMELESS TIMM17A TK1 TLR1 TLR5 TLR7 TLR8 TM9SF4 TMA16 TMCC3 TMEM123 TMEM154 TMEM154 TMEM158 TMEM198 TMEM239 TMEM260 TMEM37 TMEM86A TMPO TNFAIP2 TNFRSF1B TNFRSF1B TNFRSF22 TNIP1 TNIP1 TNNI2 TNS1 TOB2 TOP2A TOR3A TOR3A TPBG TPBG TPR TPX2 TREM1 TREM2 TREML1 TRERF1 TREX1 TREX1 TRIB1 TRIM25 TRIM30 TRIM47 TRIM65 TRIP10 TRIP11 TRP53BP1 TRP53I5 TRP63 TRP73 TRPC7 TSC22D3 TSC22D3 TSHZ2 TSPAN17 TSPAN2 TSPAN6 TSPAN7 TTBK2 TTC7A TTM2 TTYH3 TUBA1 TUBE1 TXNIP TXNRD1 TYKI TYMS UBAP2L UBE1X UBE2A UBE2S UBE2S UBE2T UNC5B UNE2Q2 UNG URHF1 USP1 USP18 USP34 UST UTP11L UTRN VAV1 VCPIP1 VEGFA VIL2 VMN1R90 VOPP1 WAC WASPIP WBP1 WDHD1 WFDC17 WFDC5 WFIKKN2 WHSC1 WRB XIST XYLT2 YWHAQ ZBTB4 ZC3H12C ZFHC1B ZFHX3 ZFP106 ZFP207 ZFP263 ZFP352 ZFP36 ZFP367 ZFP414 ZFP53 ZFP710 ZFP90 ZFPM1 ZMYM3 ZNF367 ZNRF1 ZRANB3 ZWILCH

Borrelia burgdorferi Induces TLR1 and TLR2 in Human Microgliaand Peripheral Blood Monocytes but Differentially RegulatesHLA-Class II Expression Cassiani-Ingoni et al, 2006

Upregulated in microglia: CCR7 CXCL12 IL1R2 MARCO NFKB2 TLR2 Downregulated in microglia: CXCL13 HLA-DQB1 PGDS TREM2

Up in monocytes: CCR2 CCR7 CD44 CXCL13 MARCO SOCS3 TLR2 TREM1

Gene expression changes in monocytes and microglia following stimulation with B. burgdorferi. A2M ABCB1 ABCC5 ABCG2 ACTA2 ADA ADAM28 ADCY9 ADM ADORA2A AK3 ALDOC ANKH ANPEP ARG2 ASRGL1 ATF5 ATIC ATP1B1 AXL BAIAP2 BBOX1 BCKDHB BCL3 BCL7C BHC80 BPAG1 C16ORF62 C16orf7 C1QB C1QR1 C3 CALD1 CAV1 CCBP2 CCND1 CCR2 CCR7 CD2BP2 CD44 CD74 CDA CDC42EP2 CDW52 CES1 CFLAR CLC CLCN4 CLECSF13 CLTC CORO2B CRIP1 CRYM CSPG2 CSRP2 CTPS CX3CR1 CXCL12 CXCL13 CYP39A1 DBN1 DF DIPA DKK3 DOK4 DPEP1 DPP4 DTNA DTNB DTR E2IG4 EDNRA EDNRB EEG1 EFNB2 EGFR EHD1 EIF4A1 EML3 EMR1 EMR2 EPAS1 EPS8 ERO1L ETV5 FAM12A FARP1 FBP1 FCAR FCER1A FCN1 FGF18 FOXM1 FPRL1 FRS3 G0S2 GABARAPL3 GAL3ST-4 GAP43 GCLC GH1 GK GNA15 GNG11 GPR126 GPRC5B GPRK6 GRM1 GYPA GYS1 HADHSC HBA1 HBB HCA112 HCAP-G HCK HLA-DMA HLA-DPA1 HLA-DPB1 HLA-DQA1 HLA-DQB1 HLA-DQB2 HLA-DRB3 HMBS HS3ST2 HSD17B2 HSPA6 IGF1 IGHG3 IGL@ IGLJ3 IGSF4 IKBKE IL13RA2 IL1R2 IMP-2 IMP3 ING1 INPP4B IQSEC1 IRAK3 IRX5 ITGA4 ITGB1 JAG1 KCNJ15 KCNMA1 KDM4B KHDRBS3 KIAA0233 KIAA1199 KIF20A KIF23 KIF25 LALP1 LAMB3 LAMC1 LAMP3 LCP1 LEF1 LEP LGMN LILRA3 LILRB1 LILRB2 LILRB3 LIMCH1 LIMK2 LIPA LIR9 LR8 LY9 MAC30 MAGEA12 MAOA MAP4K1 MARCO MDK MEF2C MERTK MET MGC27165 MGC29643 MGST2 MHC2TA MIF MLF1 MMP14 MOBP MPO MRC1 MRC2 MS4A3 MSCP MSR1 NALP2 NAP1L2 NBEAL2 NDRG1 NEFH NF1 NFKB2 NFKBIA NR2E1 NR2F2 NS3TP2 ODZ4 P2RY6 PBF PBP PDE11A PDE9A PELI2 PFKFB4 PGDS PHYH PID1 PKD2L1 PKM2 PLAC4 PLEKHC1 PLP2 PLTP PON2 POU2AF1 PPAP2B PRF1 PRKACB PRKCSH PROS1 PSMB8 PTGIR PTN PTPN1 PTPN2 PTRF PVRL2 QPRT R3HDM4 RAB27A RBM10 RC3 RDC1 RDHL RGS1 RHOBTB1 RIS1 RNASE4 RNASEP1 RNF128 RRAS RTP801 RUVBL1 RXRA S100A12 S100A9 SAA2 SAMD4 SDC1 SDF2L1 SEMA4C SEMA4F SEPP1 SERPINA1 SERPINB2 SERPINE1 SH3BP5 SHQ1 SIAT4A SIGLEC8 SLC11A1 SLC16A10 SLC21A11 SLC22A17 SLC25A22 SLC25A5 SLC28A1 SLC2A14 SLC2A3 SLC35E1 SLC50A1 SMP3 SNX7 SOCS3 SOD2 SOGA1 STMN1 SULT1C1 T1A2 TBC1D16 TCL6 TGFB2 THBS1 TIMM17A TIMP1 TLR2 TM4SF10 TNC TNFAIP3 TNFRSF1B TNFRSF8 TNIP1 TPI1 TREM1 TREM2 TRG@ TRIM2 "TRIP10 VEGF VEGF VEGF WNT5A ZFP36L1 TSC2 VPS45A WSX1 ZNF395 ZYX

Down in monocytes: CX3CR1 HLA-DMA HLA-DPA1 HLA-DPB1 HLA-DQA1 HLA-DQB1 HLA-DQB2 HLA-DRB3 IL1R2 MHC-II-TA TREM2

Diseases associated with Borrelia Burgdorferi

 

 
 
     

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Last update: October 12, 2016