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Parasites - American Trypanosomiasis (also known as Chagas Disease) (CDC) Parasite Host Cell Interaction 2D-PAGE database     Baron S, editor. Medical Microbiology. 4th edition. Galveston (TX): University of Texas Medical Branch at Galveston; 1996. Available from: NCBI Books Wikipedia
Ongoing clinical trails, worldwide, can be interrogated at ClinicalTrials.Gov a service of the US National Institutes of Health

 

 

Host genes and proteins used by Trypanosoma Cruzi during its life cycle.

If you know of other interactions, (or corrections) please with Pubmed ID, gene symbol/accession number and interacting protein. Thank you.

  1. A2M alpha-2-macroglobulin : A2M and PZP interact with T.Cruzi cruzipain Ramos et al, 2002
  2. ACE angiotensin I converting enzyme : The ACE inhibitor captopril increases the intensity of T. cruzi infection of human monocytes in vitro Coelho dos Santos et al, 2010.
  3. ADIPOQ adiponectin, C1Q and collagen domain containing : Increased expression of AKT1 CCND1, HEY1, HES5, IL1B, IFNG, IRS1, NOTCH1 TNF, CCL2, CCL5, CXCL10, MAPK1 (erk) , PIK3R1, RETN, TLR2 and TLR9 and decreased ADIPOQ, CAV1 and PPARG following infection of cultured adipocytes with T. cruzi Nagajyothi et al, 2008
  4. AKT1 AKT serine/threonine kinase 1: Increased expression of AKT1 CCND1, HEY1, HES5, IL1B, IFNG, IRS1, NOTCH1 TNF, CCL2, CCL5, CXCL10, MAPK1 (erk) , PIK3R1, RETN, TLR2 and TLR9 and decreased ADIPOQ, CAV1 and PPARG following infection of cultured adipocytes with T. cruzi Nagajyothi et al, 2008
  5. ALB albumin: Transferrin and albumin are taken up by T.cruzi intracellular amastigotes Batista et al, 2015.
  6. ALOX5 arachidonate 5-lipoxygenase: the acute phase of T.cruzi infection is attenuated in ALOX5-deficient mice Canavaci et al, 2014
  7. ANKFY1 ankyrin repeat and FYVE domain containing 1: ANKFY1, Pak1 and actin microfilaments, which participate in macropinosome formation, localize at T. cruzi entry sites Barrias et al, 2012.
  8. ANXA2 annexin A2 : ARF6 and Annexin A2 play a role in parasite cell invasion Teixeira et al, 2015
  9. APOA1 apolipoprotein A1: susceptible to cruzipain cleavage Miao et al, 2014
  10. ARF6 ADP ribosylation factor 6: ARF6 and Annexin A2 play a role in parasite cell invasion Teixeira et al, 2015
  11. ARG1 arginase 1:ARG1 CCL2 CCL5 CD4 CD8A CD68 IFNG IL4 IL6 IL10 ITGAX NOS2 PTPRC TNF cardiac expression increased 14 days post infection in mice Guerrero et al, 2015
  12. ATG5 autophagy related 5 : Lack of Atg5 or the reduced expression of Beclin1 limited parasite entry and reduced the association between T.Cruzi parastic vacuoles and the lysosomal marker Lamp-1 Romano et al, 2009
  13. BDKRB2 bradykinin receptor B2: pharmacological targeting of the C5a receptor (C5aR) or the bradykinin B2 receptor (B2R) inhibited plasma leakage in hamster cheek pouch topically exposed to tissue culture trypomastigotes Schmitz et al, 2014
  14. BECN1 Beclin 1: Lack of Atg5 or the reduced expression of Beclin1 limited parasite entry and reduced the association between T.Cruzi parastic vacuoles and the lysosomal marker Lamp-1 Romano et al, 2009Romano et al, 2009
  15. C5AR1 complement component 5a receptor 1 : pharmacological targeting of the C5a receptor (C5aR) or the bradykinin B2 receptor (B2R) inhibited plasma leakage in hamster cheek pouch topically exposed to tissue culture trypomastigotes Schmitz et al, 2014
  16. CAV1 Caveolin 1: Increased expression of AKT1 CCND1, HEY1, HES5, IL1B, IFNG, NOTCH1 TNF, CCL2, CCL5, CXCL10, MAPK1 (erk) TLR2 and TLR9 and decreased ADIPOQ and CAV1 following infection of cultured adipocytes with T. cruzi Nagajyothi et al, 2008
  17. CCL2 C-C motif chemokine ligand 2: CCL2 CCL5 ARG1 CD4 CD8A CD68 IFNG IL4 IL6 IL10 ITGAX NOS2 PTPRC TNF cardiac expression increased 14 days post infection in mice Guerrero et al, 2015
  18. CCND1 cyclin D1 Increased expression of AKT1 CCND1, HEY1, HES5, IL1B, IFNG, IRS1, NOTCH1 TNF, CCL2, CCL5, CXCL10, MAPK1 (erk) , PIK3R1, RETN, TLR2 and TLR9 and decreased ADIPOQ, CAV1 and PPARG following infection of cultured adipocytes with T. cruzi Nagajyothi et al, 2008
  19. CD8A: CCL2 CCL5 ARG1 CD4 CD8A CD68 IFNG IL4 IL6 IL10 ITGAX NOS2 PTPRC TNF cardiac expression increased 14 days post infection in mice Guerrero et al, 2015
  20. CD33 parasite-derived mucins bind to the mammalian acid-binding Tg-like lectin, Siglec-E (CD33) Nardy et al, 2013
  21. CD40 molecule : T. cruzi is able to induce the expression of CD40 in HL-1 murine cardiomyocytes increasing IL6 production Ayala et al, 2015.
  22. CD40LG CD40 ligand: T. cruzi trypomastigotes and tGPI-mucins are potent inducers of IL12 by human peripheral blood monocytes and this effect depends on CD40-CD40LG interaction and IFNG Abel et al, 2014.
  23. CD68: CCL2 CCL5 ARG1 CD4 CD8A CD68 IFNG IL4 IL6 IL10 ITGAX NOS2 PTPRC TNF cardiac expression increased 14 days post infection in mice Guerrero et al, 2015
  24. CD274: infection induces the expression of CD274 (PD-L1) and the production and expression of IL10 and TLR2 in dendritic cells da Costa et al, 2014.
  25. CDH1 cadherin 1: increased expression levels of CDH1 FOLR2 MRC1 PLA2G7 PSAP SEPP1 TREM2 in CD11b+ cells of infected mice PLA2G7 PSAP Cuervo et al, 2011
  26. CHAT choline O-acetyltransferase : A neurotrophic factor (PDNF) produced by T.cruzi binds NGF receptor TrkA, stimulates mRNA and protein expression of CHAT and vesicular acetylcholine transporterSLC18A3 Akpan et al, 2008
  27. CLASP1 cytoplasmic linker associated protein 1:inhibition of GSK3ß activity enhances T. cruzi entry in a CLASP1-dependent manner Zhao et al, 2013.
  28. CR1 complement component 3b/4b receptor 1 (Knops blood group) : A lower Trypanosoma cruzi phagocytic index and higher nitric oxide levels were characteristics of monocytes from Chagas disease patients . The impaired phagocytic capacity did not reflect on the levels of anti-T. cruzi IgG, but was detectable in the downregulation of Fc receptors, TLR and CR1 molecules Gomes et al, 2012
  29. CSF3 colony stimulating factor 3 : The levels of GATA4, MEF2C and desmin mRNA decreased in acutely infected mouse hearts, and were normalized or enhanced by CSF3 treatment González et al, 2013
  30. CTLA4 cytotoxic T-lymphocyte associated protein 4 : CTLA4, PDCD1, IL10, IFNG, and NOS2 genes induced during acute T. cruzi infection in BALB/c and C57BL/6 mice Dias et al, 2015.
  31. CX3CL1 (fractalkine) . T.cruzi upregulates CCL2 and CX3CL1 in cellular and mouse models of heart infection via parasite-derived neurotrophic factor (PDNF)/trans-sialidase with neurotrophic receptors TrkA and TrkC Salvador et al, 2014
  32. CXCL10: CCND1 cyclin D1: Increased expression of AKT1 CCND1, HEY1, HES5, IL1B, IFNG, IRS1, NOTCH1 TNF, CCL2, CCL5, CXCL10, MAPK1 (erk) , PIK3R1, RETN, TLR2 and TLR9 and decreased ADIPOQ, CAV1 and PPARG following infection of cultured adipocytes with T. cruzi Nagajyothi et al, 2008
  33. CYBA cytochrome b-245 alpha chain (p22phox): PTGS2, thromboxane synthase, inducible nitric oxide synthase (iNOS), p65 NFKB subunit (RELA) and p22phox of NAD(P)H oxidase (NOX) subunit expressions were increased in vessels of chagasic animals Silva et al, 2016.
  34. DEFA1 defensin alpha 1: kills the parasite, Madison et al, 2007
  35. EXOC4 exocyst complex component 4: EXOC4 and EXOC7 recruited to T. cruzi parasitophorous vacuoles and are required for host cell invasion Fernandes et al, 2015.
  36. EXOC7 exocyst complex component 7: EXOC4 and EXOC7 recruited to T. cruzi parasitophorous vacuoles and are required for host cell invasion Fernandes et al, 2015.
  37. FN1 fibronectin. degraded by T.Cruzi protease (cruzipain) Maida et al, 2014
  38. FOLR2 folate receptor beta: FOLR2 MRC1 PLA2G7 PSAP SEPP1 TREM2 in CD11b+ cells of infected mice PLA2G7 PSAP Cuervo et al, 2011
  39. GATA4 GATA binding protein 4: The levels of GATA4, MEF2C and desmin mRNA decreased in acutely infected mouse hearts, and were normalized or enhanced by CSF3 treatment González et al, 2013
  40. GNLY granulysin : delivers granzymes into three protozoan parasites (Trypanosoma cruzi, Toxoplasma gondii and Leishmania major) Dotiwala et al, 2016
  41. GSK3B glycogen synthase kinase 3 beta :inhibition of GSK3ß activity enhances T. cruzi entry in a CLASP1-dependent manner Zhao et al, 2013.
  42. GZMB granzyme B :GNLY and GzmB cause oxidative damage–mediated parasite programmed cell death Dotiwala et al, 2016
  43. HES5 hes family bHLH transcription factor 5 : Increased expression of AKT1 CCND1, HEY1, HES5, IL1B, IFNG, IRS1, NOTCH1 TNF, CCL2, CCL5, CXCL10, MAPK1 (erk) , PIK3R1, RETN, TLR2 and TLR9 and decreased ADIPOQ, CAV1 and PPARG following infection of cultured adipocytes with T. cruzi Nagajyothi et al, 2008
  44. HEY1 hes related family bHLH transcription factor with YRPW motif 1:Increased expression of AKT1 CCND1, HEY1, HES5, IL1B, IFNG, IRS1, NOTCH1 TNF, CCL2, CCL5, CXCL10, MAPK1 (erk) , PIK3R1, RETN, TLR2 and TLR9 and decreased ADIPOQ, CAV1 and PPARG following infection of cultured adipocytes with T. cruzi Nagajyothi et al, 2008
  45. HLA-DRB1 DRB1*0409 and DRB1*1503 alleles were significantly more prevalent in T.Cruzi seropositives García Borrás et al, 2009
  46. HPGDS hematopoietic prostaglandin D synthase:Ptges , Hpgds and Tbxas1 increased in heart tissue during the acute phase of T. cruzi infection in mice Guerrero et al, 2015
  47. IFNG interferon gamma: CCL2 CCL5 ARG1 CD4 CD8A CD68 IFNG IL4 IL6 IL10 ITGAX NOS2 PTPRC TNF cardiac expression increased 14 days post infection in mice Guerrero et al, 2015 IFNG promotes T.Cruzi invasion of astrocytes Silva et al, 2015
  48. IL1B Interleukin 1 beta: Increased expression of AKT1 CCND1, HEY1, HES5, IL1B, IFNG, NOTCH1 TNF, CCL2, CCL5, CXCL10, MAPK1 (erk) TLR2 and TLR9 and decreased ADIPOQ and CAV1 following infection of cultured adipocytes with T. cruzi Nagajyothi et al, 2008
  49. IL6 Interleukin 6: T. cruzi is able to induce the expression of CD40 in HL-1 murine cardiomyocytes increasing IL6 production Ayala et al, 2015.
  50. IL7 Interleukin 7: perturbed IL7/IL7R T cell signaling through STAT5 is a potential mechanism of T cell exhaustion in chronic T. cruzi infection Albareda et al, 2015.
  51. IL7R interleukin 7 receptor : perturbed IL7/IL7R T cell signaling through STAT5 is a potential mechanism of T cell exhaustion in chronic T. cruzi infection Albareda et al, 2015.
  52. IL10: CTLA4, PDCD1, IL10, IFNG, and NOS2 genes induced during acute T. cruzi infection in BALB/c and C57BL/6 mice Dias et al, 2015.
  53. IL12 T. cruzi trypomastigotes and tGPI-mucins are potent inducers of IL12 by human peripheral blood monocytes and this effect depends on CD40-CD40L interaction and IFNG Abel et al, 2014.
  54. IL17A IL17A and TNF expression increased in CD4-CD8- T cells from T. cruzi infected mice Lepletier et al, 2014
  55. IRS1 insulin receptor substrate 1: Increased expression of AKT1 CCND1, HEY1, HES5, IL1B, IFNG, IRS1, NOTCH1 TNF, CCL2, CCL5, CXCL10, MAPK1 (erk) , PIK3R1, RETN, TLR2 and TLR9 and decreased ADIPOQ, CAV1 and PPARG following infection of cultured adipocytes with T. cruzi Nagajyothi et al, 2008
  56. ITGAX integrin subunit alpha X: CCL2 CCL5 ARG1 CD4 CD8A CD68 IFNG IL4 IL6 IL10 ITGAX NOS2 PTPRC TNF cardiac expression increased 14 days post infection in mice Guerrero et al, 2015
  57. KIR2DL2 killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 2:KIR2DL2 and KIR2DS2 related to immunopathogenesis in Chagas diseaseAyo et al, 2015
  58. KIR2DS2 killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 2:KIR2DL2 and KIR2DS2 related to immunopathogenesis in Chagas diseaseAyo et al, 2015
  59. LDLR low density lipoprotein receptor: Trypanosoma cruzi uses LDLR for invasion Nagajyothi et al, 2011.
  60. LGALS1 galectin 1: Lgals1(-/-)) mice exhibited reduced mortality and lower parasite load in muscle tissue Poncini et al, 2015
  61. LGALS3 lectin, galactoside binding soluble 3 : Lack of Galectin-3 Prevents Cardiac Fibrosis and Effective Immune Responses in a Murine Model of Trypanosoma cruzi Infection Pineda et al, 2015
  62. MAP1LC3A microtubule associated protein 1 light chain 3 alpha (Lc3): the vacuole containing T. cruzi is decorated by this host cell autophagic protein Romano et al, 2009
  63. MAPK1 mitogen-activated protein kinase 1 : Increased expression of AKT1 CCND1, HEY1, HES5, IL1B, IFNG, IRS1, NOTCH1 TNF, CCL2, CCL5, CXCL10, MAPK1 (erk) , PIK3R1, RETN, TLR2 and TLR9 and decreased ADIPOQ, CAV1 and PPARG following infection of cultured adipocytes with T. cruzi Nagajyothi et al, 2008
  64. MEF2C myocyte enhancer factor 2C: The levels of GATA4, MEF2C and desmin mRNA decreased in acutely infected mouse hearts, and were normalized or enhanced by CSF3 treatment González et al, 2013
  65. MICA MHC class I polypeptide-related sequence A: MICA-129 polymorphism associated with the Severity of Chronic Chagas Heart Disease Ayo et al, 2015.
  66. MRC1 mannose receptor, C type 1: increased expression levels of CDH1 FOLR2 MRC1 PLA2G7 PSAP SEPP1 TREM2 in CD11b+ cells of infected mice PLA2G7 PSAP Cuervo et al, 2011
  67. NOS2 nitric oxide synthase 2 : PTGS2, thromboxane synthase, inducible nitric oxide synthase (iNOS), p65 NFKB subunit (RELA) and p22phox of NAD(P)H oxidase (NOX) subunit expressions were increased in vessels of chagasic animals Silva et al, 2016.
  68. NOTCH1: Increased expression of AKT1 CCND1, HEY1, HES5, IL1B, IFNG, IRS1, NOTCH1 TNF, CCL2, CCL5, CXCL10, MAPK1 (erk) , PIK3R1, RETN, TLR2 and TLR9 and decreased ADIPOQ, CAV1 and PPARG following infection of cultured adipocytes with T. cruzi Nagajyothi et al, 2008
  69. NTRK1 neurotrophic receptor tyrosine kinase 1: Trypanosoma cruzi highjacks TrkC to enter cardiomyocytes and cardiac fibroblasts and exploits TrkA (NTRK1) for cardioprotection against oxidative stress Aridgides et al, 2013.
  70. NTRK3 neurotrophic receptor tyrosine kinase 3; entry receptor for Trypanosoma cruzi in neural, glial, and epithelial cells Weinkauf et al, 2011
  71. ODC1 ornithine decarboxylase 1: Inhibition failed to modify infection in CHO cells but significantly decreased infection in Vero cells Vanrell et al, 2013
  72. PAK1 p21 (RAC1) activated kinase 1: ANKFY1, Pak1 and actin microfilaments, which participate in macropinosome formation, localize at T. cruzi entry sites Barrias et al, 2012.
  73. PDCD1 programmed cell death 1: CTLA4, PDCD1, IL10, IFNG, and NOS2 genes induced during acute T. cruzi infection in BALB/c and C57BL/6 mice Dias et al, 2015.
  74. PIK3R1 phosphoinositide-3-kinase regulatory subunit 1: Increased expression of AKT1 CCND1, HEY1, HES5, IL1B, IFNG, NOTCH1 TNF, CCL2, CCL5, CXCL10, MAPK1 (erk) , PIK3R1, RETN, TLR2 and TLR9 and decreased ADIPOQ and CAV1 following infection of cultured adipocytes with T. cruzi Nagajyothi et al, 2008
  75. PLA2G7 phospholipase A2 group VII: increased expression levels of CDH1 FOLR2 MRC1 PLA2G7 PSAP SEPP1 TREM2 in CD11b+ cells of infected mice PLA2G7 PSAP Cuervo et al, 2011
  76. PPARA peroxisome proliferator activated receptor alpha : PPARA and PPARG are involved in the in vitro polarization of macrophages isolated from T. cruzi-infected mice Penas et al, 2015.
  77. PPARG peroxisome proliferator activated receptor gamma : PPARA and PPARG are involved in the in vitro polarization of macrophages isolated from T. cruzi-infected mice Penas et al, 2015.
  78. PRF1 perforin 1: GNLY, PRF1 and GzmB kill the parasites Dotiwala et al, 2016.
  79. PROKR2 prokineticin receptor 2: Entry receptor in mammalian cells Khusal et al, 2015
  80. PSAP prosaposin: increased expression levels of CDH1 FOLR2 MRC1 PLA2G7 PSAP SEPP1 TREM2 in CD11b+ cells of infected mice PLA2G7 PSAP Cuervo et al, 2011
  81. PTGER2 prostaglandin E receptor 2: both, COX-2 and EP-2 signaling contribute significantly to the heart leukocyte infiltration and to the release of chemokines and inflammatory cytokines in the heart of T. cruzi infected mice Guerrero et al, 2015
  82. PTGES prostaglandin E synthase: . Ptges , Hpgds and Tbxas1 increased in heart tissue during the acute phase of T. cruzi infection in mice Guerrero et al, 2015
  83. PTGS2 prostaglandin-endoperoxide synthase 2 :PTGS2, thromboxane synthase, inducible nitric oxide synthase (iNOS), p65 NFKB subunit (RELA) and p22phox of NAD(P)H oxidase (NOX) subunit expressions were increased in vessels of chagasic animals Silva et al, 2016.
  84. PTK2 protein tyrosine kinase 2 (FAK): FAK and Src are involved in the invasion of cardiomyocytes by T. cruzi.Melo et al, 2014
  85. PTPRC protein tyrosine phosphatase, receptor type C: ARG1 CCL2 CCL5 CD4 CD8A CD68 IFNG IL4 IL6 IL10 ITGAX NOS2 PTPRC TNF cardiac expression increased 14 days post infection in mice Guerrero et al, 2015
  86. PZP Pregnacy zone protein, alpha-2-macroglobulin like: A2M and PZP interact with T.Cruzi cruzipain Ramos et al, 2002
  87. RELA RELA proto-oncogene, NF-kB subunit: PTGS2, thromboxane synthase, inducible nitric oxide synthase (iNOS), p65 NFKB subunit (RELA) and p22phox of NAD(P)H oxidase (NOX) subunit expressions were increased in vessels of chagasic animals Silva et al, 2016.
  88. RETN resistin: Increased expression of AKT1 CCND1, HEY1, HES5, IL1B, IFNG, IRS1, NOTCH1 TNF, CCL2, CCL5, CXCL10, MAPK1 (erk) , PIK3R1, RETN, TLR2 and TLR9 and decreased ADIPOQ, CAV1 and PPARG following infection of cultured adipocytes with T. cruzi Nagajyothi et al, 2008
  89. S1PR1 sphingosine-1-phosphate receptor 1: increased ed thymic expression of S1PR1 and S1PR3 in T. cruzi-infected mice Lepletier et al, 2014
  90. SEPP1 selenoprotein P, plasma, 1 : increased expression levels of CDH1 FOLR2 MRC1 PLA2G7 PSAP SEPP1 TREM2 in CD11b+ cells of infected mice PLA2G7 PSAP Cuervo et al, 2011
  91. SPHK1 sphingosine kinase 1: reduced thymic expression of SPHK1 and SPHK2 in T. cruzi-infected mice Lepletier et al, 2014
  92. SRC SRC proto-oncogene, non-receptor tyrosine kinase : FAK and Src are involved in the invasion of cardiomyocytes by T. cruzi.Melo et al, 2014
  93. STAT5A signal transducer and activator of transcription 5A: perturbed IL7/IL7R T cell signaling through STAT5 is a potential mechanism of T cell exhaustion in chronic T. cruzi infection Albareda et al, 2015.
  94. TBXA2R thromboxane A2 receptor. T. cruzi invades mice aorta endothelial cells and increases TXA2/TP receptor/NOX-derived superoxide formation Silva et al, 2016
  95. TBXAS1 thromboxane A synthase 1: PTGS2, thromboxane synthase, inducible nitric oxide synthase (iNOS), p65 NFKB subunit (RELA) and p22phox of NAD(P)H oxidase (NOX) subunit expressions were increased in vessels of chagasic animals Silva et al, 2016.
  96. TF transferrin: Transferrin and albumin are taken up by T.cruzi intracellular amastigotes Batista et al, 2015.
  97. TGFBR1 transforming growth factor beta receptor 1: T. cruzi attaches to, but cannot penetrate,epithelial cells expressing defective TGFBR1 or TGFBR2 Ming et al, 1995
  98. TGFBR2 transforming growth factor beta receptor 2: the co-localization of TGFBR2 with costameres is important in activating the TGFB1 signalling cascade, and T. cruzi-derived cytoskeleton disorganization could result in altered or low TGF-ß response in infected cardiomyocytes Calvet et al, 2016.
  99. TLR2 toll like receptor 2: infection induces the expression of CD274 (PD-L1) and the production and expression of IL10 and TLR2 in dendritic cells da Costa et al, 2014.
  100. TLR9: Increased expression of AKT1 CCND1, HEY1, HES5, IL1B, IFNG, IRS1, NOTCH1 TNF, CCL2, CCL5, CXCL10, MAPK1 (erk) , PIK3R1, RETN, TLR2 and TLR9 and decreased ADIPOQ, CAV1 and PPARG following infection of cultured adipocytes with T. cruzi Nagajyothi et al, 2008
  101. TNF tumor necrosis factor: serum TNF increased in infected mice Silva et al, 2016
  102. TREM2 triggering receptor expressed on myeloid cells 2 : Increased expression levels of CDH1 FOLR2 MRC1 PLA2G7 PSAP SEPP1 TREM2 in CD11b+ cells of infected mice PLA2G7 PSAP Cuervo et al, 2011
  103. VIP vasoactive intestinal peptide reduces the inflammatory profile in mice infected with Trypanosoma cruzi Higyno et al, 2015.

Bulk experiments

Early Regulation of Profibrotic Genes in Primary Human Cardiac Myocytes by Trypanosoma cruzi.Udoko et al, 2016

misregulated genes ACTA2 AGT AKT1 BCL2 BMP7 CAV1 CCL11 CCL2 CCL3 CCR2 CEBPB COL1A2 COL3A1 CTGF CXCR4 DCN EDN1 EGF ENG FASLG GREM1 HGF IFNG IL10 IL13 IL13RA2 IL1A IL1B IL4 IL5 ILK INHBE ITGA1 ITGA2 ITGA3 ITGAV ITGB1 ITGB3 ITGB5 ITGB6 ITGB8 JUN LOX LTBP1 MMP1 MMP13 MMP14 MMP2 MMP3 MMP8 MMP9 MYC NFKB1 PDGFA PDGFB PLAT PLAU PLG SERPINA1 SERPINE1 SERPINH1 SMAD2 SMAD3 SMAD4 SMAD6 SMAD7 SNAI1 SP1 STAT1 STAT6 TGFB1 TGFB2 TGFB3 TGFBR1 TGFBR2 TGIF1 TNF VEGFA

Early Trypanosoma cruzi Infection Reprograms Human Epithelial Cells Chiribao et al, 2014

Downregulated genes: ABCA11P ACAD11 ACOX3 ADRA2A AGBL1 ANK3 ARID5B ARMC9 BNC2 C1QTNF3 C1RL CA9 CCNA1 CDC42BPG CEBPA CEP290 CNR1 COX18 CXXC4 DHDDS DLC1 DNAJC21 EIF3H ELL2 ELP2 ERMAP FBXO36 FUBP1 GABPB2 GNAZ GRAMD4 GREM2 GSK3B HAUS5 HCFC1 KIAA1958 KRCC1 KRT19 LCLAT1 LGR6 LMLN LOC100505956 LOC100507100 LOC151009 LOC253039 LOC400604 LOC643401 LRRC20 LRRIQ1 MAP1A METTL7A MOBKL2B MTHFR MTR NAIP NCKAP5 NCRNA00174 NEBL NEK9 NFE2 NKX3-2 NUDT18 NYNRIN PAIP2B PCBD2 PCDH11Y PCM1 PCSK1 PDE1A PDE8B PDGFRB PLCXD3 PRKCB PSMD9 PTPLAD2 RAB3C RBM14 RBM43 RFX3 RGNEF SCAI SEC31B SIPA1L3 SIRT3 SLC24A3 SLC2A11 SORBS2 SPINK13 SYTL5 TFDP2 TMEM187 TRERF1 TRIM6 TRIM66 TRMT1L USP47 WDR60 ZBTB1 ZNF160 ZNF181

Upregulated genes: A1BG ABCA5 ABCC8 ABTB2 ACSM5 ADAMTS17 ADH6 AGBL4 AKT3 ANKRD33B ANKRD55 AREG ARHGAP20 ARHGEF15 B3GNT5 BCL2A1 BDKRB1 BEND7 BIRC2 BIRC3 BLNK BTN3A1 CADM3 CASQ2 CBR3 CCKBR CCL2 CCL20 CCL3 CCL8 CD96 CDC42EP2 CDHR3 CEACAM5 CEBPD CFB CFHR2 CLDN1 CNKSR1 CNTNAP2 CPA2 CREB3L3 CREB5 CRYBA2 CSF3 CST9L CTSS CXCL1 CXCL2 CXCL3 CYP3A5 CYP4F11 DDX58 DLGAP1 DMRT2 DNAH5 DNAJC6 DNHD1 DRD3 DUSP5 DUSP6 EFNA1 EGR1 EHF EID3 EIF4E ELOVL7 EPB41L5 ERBB2 EREG ESAM FAM131B FAM19A1 FAM27L FBXW10 FGF16 FGF17 FLG FLJ44715 FNDC7 FOSL1 FRMPD4 FSD2 G0S2 GATM GATS GBP3 GBX1 GCH1 GFPT2 GHR GIPC2 GLS GLTSCR1 GRK4 GUCY1A3 GYPE HAVCR2 HBEGF HBM HEATR7B2 HHIP HIST1H3I HIVEP3 HRASLS5 ICAM1 IER3 IER5 IFIH1 IFNA16 IGLL1 IL11 IL1A IL1B IL26 IL6 IL7 IL8 INHBA INSM2 IQCF1 IVL JSRP1 KBTBD3 KBTBD8 KCNB2 KCNE2 KCNJ14 KLF14 KLRF1 LCN2 LGALS9 LIF LILRB5 LIX1 LMO2 LOC100130691 LOC100505974 LOC100506123 LOC100506546 LOC100506983 LOC100507033 LOC100507203 LOC100507419 LOC283174 LOC387895 LOC401317 LOC441495 LOC643733 LOC644192 LOC646626 LRRC2 LRRC27 LRRC4C MAFF MAFIP MAP2K3 MAP3K8 MGC42157 MOV10L1 MT1B MT1G MT1L MT1X MX1 MYCT1 MYH8 NACC1 NAMPT NCOA7 NCRNA00246A NFATC1 NFKB1 NFKB2 NFKBIA NFKBIE NFKBIZ NFRKB NINJ1 NLN NPSA OLR1 P2RY8 PALM2-AKAP2 PANX1 PAQR6 PARP14 PCDH15 PCDHB6 PCSK6 PDZD9 PGBD5 PGF PHLDA1 PI3 PIH2 PIK3IP1 PLA2G2F PLA2G7 PMAIP1 PNCK PNMAL1 POM121L8P PP12613 PRKG1 PRO2949 PRSS36 PSG9 PTGS2 PTX3 RAMP2 RASD1 RBM46 RECQL RELB RGR RHO RNF148 RNF19B RNF8 RSAD2 RSPH6A RSPH9 SAA2 SAMD4A SAT1 SCML2 SCN4A SDC4 SEMA7A SEMG2 SERPINB8 SERTAD1 SHROOM2 SLC12A7 SLC26A10 SLC30A4 SLC8A2 SLC9A6 SLED1 SLFN5 SMAD3 SMOX SOD2 SOD2 SP100 SPEM1 SPP1 SPTBN4 SRG7 SRXN1 STATH STX11 SULT2A1 SULT2B1 SYCE2 SYNE1 TACR1 TANC2 TAPT1 TAS2R20 TCF15 TCL6 TEKT1 TIFA TMCC3 TMEM119 TMEM200A TMEM201 TMEM8A TMX4 TNF TNFAIP2 TNFAIP3 TNFAIP6 TNFSF14 TNIP1 TNIP3 TNR TPD52L3 TPPP3 TRAF3IP3 TSPYL5 UNC80 USP9Y WDR49 WFDC10A WNT10A WTAP XAF1 ZC3H12A ZC3H12C ZDHHC11 ZIM3 ZNF135 ZNF333 ZNF347 ZNF577 ZNF682 ZNF697

Gene network analysis during early infection of human coronary artery smooth muscle cells by Trypanosoma cruzi and Its gp83 ligand. Nde et al, 2010

ATF5 Sub-network interaction ATF5 BATF CCND3 CDC34 CEBPA CEBPB CEBPD CEBPG DISC1 E2F1 GABBR1 GABBR2 TAF1 TRIB3

FOSB Sub-network interaction: ATF2 ATF4 ATF7 BCL6 DDIT3 FOSB FOSL1 JUN JUNB JUND MAFB SMAD4 TAF1

LAMC1 sub-network interactome mobilized in cells by T. cruzi ATF71P BCL6 CCDC53 CD44 ITGA6 ITGB4 LAMA1 LAMA5 LAMB1 LAMB2 NID1 NID2 SNAPIN SV2A SV2B SV2C

THBS1 sub-network interactome mobilized in cells by T. cruzi CALR CD36 CD47 CFH COL1A1 COL2A1 COL3A1 COL5A1 COL7A1 CORO1A CTSG DCN DHFR ELA2 F2 FGA FN1 HRG ITGA3 ITGA4 ITGAV ITGB1 ITGB3 JAG1 KNG1 LAMB3 LRP1 LRP5 LTBP1 MMP2 MMP9 PDEA PDGFB PLG SCARB2 SCD4 SDC1 SDC2 SDC3 SPARC SPP1 TFPI TGFB1 TNFAIP6 TNFRSF1A TP53 TSC2 ZNF8

Delineation of Diverse Macrophage Activation Programs in Response to Intracellular Parasites and Cytokines Zhang et al, 2010

Upregulated: ABCC4 ABCG1 ACOT9 ACP2 ACTG1 ACTR3 ADA ADAM17 ADAM8 ADAMTS1 ADAR ADFP ADPGK AEN AFP AGFG1 AGPAT5 AGTRAP AIDA AIFM2 AIG1 AKR1B1 ALDH18A1 ALDH1B1 ALG8 ALKBH1 ANGPTL4 ANKFY1 ANKIB1 ANKRD37 ANXA1 ANXA4 AP3S1 APAF1 APOBEC3F APOD APP ARG2 ARHGAP11A ARHGDIB ARID5A ASCC3 ASF1B ATAD2 ATAD5 ATF3 ATF6 ATP10A ATP1B3 ATP6V0D2 ATP6V1B2 ATP7A ATP8A1 ATP8B2 ATXN7L1 AURKB B2M B4GALT5 BAK1 BASP1 BAT5 BAZ1A BBX BCL3 BID BIRC2 BIRC5 BLNK BLVRA BLZF1 BRIP1 C11orf31 C11orf82 C12orf30 C12orf45 C13orf27 C13orf3 C13orf31 C14orf106 C14orf138 C14orf156 C14orf21 C16orf57 C17orf71 C19orf28 C19orf66 C1orf38 C1orf52 C1R C21orf45 C21orf91 C3AR1 C3orf38 C4orf3 C4orf32 C4orf43 C4orf46 C6orf115 C6orf150 C7orf28B C7orf46 C9orf103 C9orf46 C9orf91 CA13 CA9 CACNG7 CACYBP CAPZA1 CAPZA2 CASP1 CASP4 CASP7 CASP8 CASP8AP2 CCDC109B CCDC86 CCL2 CCL5 CCL7 CCNA2 CCNB1 CCR1 CCR2 CCRL2 CD40 CD44 CD47 CD53 CD69 CD86 CDC2 CDC20 CDC27 CDC42SE2 CDC6 CDCA5 CDK4 CDKN1A CDT1 CEBPB CEBPD CENPI CENPJ CENPK CEP170 CEP55 CHCHD4 CHEK1 CHEK2 CKAP4 CKS1B CLDN23 CLIC4 CMPK2 CMTM7 CNDP2 COL3A1 COL4A1 COX10 CP CREB3L2 CRELD2 CREM CSF2RB CSTB CTLA4 CTPS CTSC CTSS CTTNBP2NL CX3CL1 CXCL1 CXCL16 CXCL2 CXCL9 CXorf26 CXorf38 CYB561D2 CYBA CYBB DAXX DBF4 DBNL DCK DDHD1 DDX10 DDX21 DDX39 DDX58 DERL3 DHX58 DIS3 DKK1 DNAI1 DNAJB11 DNAJC12 DNAJC13 DNMT1 DPH2 DPP3 DSCR3 DSE DTX3L DUT E2F3 ECE2 ECT2 EDEM1 EEF1E1 EFHD2 EGR2 EHD4 EIF1AX EIF2AK2 EIF2S1 EIF4E3 EME1 EMILIN2 EMP1 EMR1 ENOPH1 ENTPD1 EPPK1 EPSTI1 ERAP1 ERH ERO1L EXOSC3 EXOSC9 EZH2 F10 F2RL2 FABP5 FABP7 FAM100B FAM26F FAM71D FAM82A2 FAM96A FAM96B FANCA FANCB FAS FBN1 FBXO6 FCER1G FEN1 FGL2 FILIP1 FKBP11 FLT4 FMNL2 FMR1 FNDC3A FOS FOSL2 FOXK2 FPR1 FST FXYD5 FYB G3BP2 GADD45B GALNT7 GAR1 GATM GBP1 GBP4 GCA GDF3 GEMIN6 GINS1 GK GLA GLIPR1 GNA13 GNB4 GNL3 GOLGA3 GOLT1B GPM6A GPNMB GPR160 GPR65 GPR97 GRN GSDMD GSG2 GTF2B GTF2F1 GYG1 HAT1 HELLS HERC6 HIF1A HIRA HK2 HLA-DMA HLA-E HMGA1 HMGB2 HMGN3 HNRNPM HPSE HSPA13 HSPA14 HSPA1B HSPA5 HSPB8 HSPH1 HUS1 ICAM1 IER3 IFI16 IFI30 IFI35 IFI44L IFIH1 IFIT1 IFIT2 IFITM1 IFITM3 IFRD1 IGF2BP2 IGHG1 IGHM IGSF8 IKBKE IKZF1 IL12RB1 IL15 IL15RA IL18 IL18BP IL1A IL1B IL1RN IL2RB IL2RG IL33 IL4R IL6 INPP1 INTS12 IRF1 IRF7 IRF8 IRF9 IRX3 ISG15 ISG20 ITGAL ITGAM ITPRIPL2 JAK2 JUN KBTBD8 KIAA0101 KIAA1432 KIAA1524 KLF6 KLRG1 LAIR1 LAP3 LASS6 LCP2 LGALS1 LGALS3 LGALS3BP LGALS9 LGMN LIG1 LITAF LPXN LRRC59 LRRC8C LRTM1 LSM2 LSM3 LTV1 LY6E LYAR MAD2L1 MAFF MAK16 MAP1S MAP3K8 MCM2 MCM3 MCM4 MCM5 MCM6 MED10 MED18 MED21 MELK METRNL METTL11A MITD1 MITF MKI67 MLKL MMP14 MOCOS MORF4L2 MOV10 MPEG1 MPHOSPH6 MRPL13 MRPL27 MRPL32 MRPL40 MRPS18C MS4A6A MS4A7 MSN MSR1 MSX2 MT2A MTBP MTF1 MTHFD1L MTHFD2 MVP MX2 MYC MYD88 MYO1F MYOF N4BP1 NAMPT NASP NAT5 NAV2 NBN NCAPG NCAPH NCF2 NFAM1 NFIL3 NFKBIE NFKBIZ NGDN NHP2L1 NIPA2 NLRP3 NME2 NMI NMRAL1 NMT1 NOC3L NOC4L NOD1 NOL11 NOP2 NOSIP NP NPC2 NRCAM NRP2 NT5C3 NUDCD1 NUDT5 NUP205 NUP35 NUP37 NUP54 NUP62 NUP93 NUPL1 NXT1 OAS2 OAS3 OASL OBFC2A OGFR OPRL1 ORC6L OSMR OXCT1 P2RX7 P4HA1 PANX1 PARP11 PARP12 PARP14 PARP3 PARP9 PCGF5 PCNA PDE7B PDIA4 PDIA6 PDK3 PDPN PFDN4 PFKP PGAM1 PGD PGK1 PGM3 PGS1 PHF15 PIM1 PION PLA2G16 PLA2G4A PLA2G7 PLAC8 PLEK PLK4 PLOD2 PLOD3 PLSCR1 PMAIP1 PML PNO1 PNPT1 POLE POLR3D POLR3K POP4 PPA1 PPAPDC1B PPID PPP2R2A PPP2R3C PPP3CC PRDM1 PRDM4 PRIM2 PRKX PRMT7 PRPF31 PRR11 PSAT1 PSMA2 PSMA5 PSMA6 PSMA7 PSMB10 PSMB2 PSMB9 PSMD14 PSME1 PSME2 PSPC1 PTGS2 PTPN1 PTPN12 PTPN2 PTPN22 PTPRE PVR PVRL2 RAB20 RAB32 RAB5C RAB7L1 RAB8B RABL5 RAD18 RAD51 RAD51AP1 RAD54L RALB RANBP1 RAP2B RARS RBL1 RBM7 RCN1 RET RFC3 RFC4 RFC5 RFX2 RG9MTD2 RHBDF2 RHOC RILPL2 RIPK1 RIPK2 RNASEH2B RNF114 RNF115 RNF149 RNF19B RNPEP RPAP3 RPN1 RPS6KC1 RPUSD1 RRBP1 RRM2 RRP12 RSAD2 RTCD1 RTP4 S100A11 S100A6 S1PR2 SAMD9L SAMHD1 SAP30 SASS6 SCFD1 SCLT1 SDC3 SDCBP SDF2L1 SEC24D SEC61B SEMA4B SERPINA3 SERPINB9 SERPING1 SERPINH1 SETDB2 SGCB SGOL1 SH3PXD2B SHCBP1 SIAH2 SIRPA SLAMF8 SLC10A2 SLC11A1 SLC15A3 SLC1A3 SLC25A22 SLC25A4 SLC30A7 SLC31A1 SLC31A2 SLC39A14 SLC39A6 SLC43A3 SLC7A1 SLCO3A1 SLFN5 SLPI SMCHD1 SMCR8 SMPDL3B SNRPA1 SNRPD1 SNRPF SNX1 SNX5 SNX6 SOAT1 SOCS1 SOCS3 SOD2 SOX9 SP100 SP110 SPEF1 SPP1 SPRYD3 SQLE SRGAP2 SRGN SRXN1 ST6GALNAC4 STAMBP STAP2 STARD3NL STAT1 STAT2 STAT3 STEAP1 STEAP4 STRN STX11 STX7 SUV39H1 TANK TAP1 TAP2 TAPBP TBK1 TBL3 TCERG1 TCIRG1 TDG TFDP1 TFEC TGFBI TGIF1 TGM2 THBS1 TIFA TIMELESS TIMP1 TINF2 TIPARP TIPIN TLR1 TLR2 TLR3 TLR4 TMED10 TMEM106A TMEM165 TMEM170A TMEM173 TMEM184B TMEM194A TMEM199 TMEM50B TMEM51 TMEM67 TMSB10 TNF TNFAIP2 TNFAIP3 TNFRSF11A TNFRSF1A TNFRSF1B TNFSF13B TNFSF9 TNIP1 TOP2A TOR1AIP1 TOR3A TPD52 TPM4 TPST1 TRAFD1 TRAIP TRIM25 TRIM6 TSKU TSPO TSR1 TTC39B TUBA1B TUBB6 TXNDC11 TXNRD1 UBE2L6 UBFD1 UPP1 USP18 USP42 UTP18 UTP23 VCAN VIM VNN3 VPS29 VRK2 VTA1 VWA5A WARS WAS WBP5 WDHD1 WDR43 WDR74 WRN XAF1 XBP1 XDH XPO1 YARS YRDC YWHAG ZC3HAV1 ZCCHC10 ZCCHC2 ZFAND2A ZNF330 ZNFX1 ZRSR2 ZSCAN22 ZUFSP ZWILCH

Downregulated: A2LD1 AACS ABCA3 ABCB10 ABCB4 ABCB6 ABCB9 ABCC3 ABCD3 ABCG2 ABHD14B ABHD4 ABHD6 ABI3BP ABLIM1 ABLIM3 ABTB1 ACAA1 ACAA2 ACAD10 ACAD8 ACADM ACADSB ACADVL ACBD4 ACLY ACO1 ACOT11 ACOX1 ACP6 ACSL1 ACTR5 ACVR2A ACY1 ACYP1 ACYP2 ADAM23 ADAMTS10 ADCK2 ADCK5 ADCY9 ADD1 ADD3 ADI1 ADIPOR1 ADIPOR2 ADNP AES AGA AGAP1 AGAP3 AGFG2 AGL AGPAT2 AK3 AKAP11 AKAP13 AKAP8L AKAP9 AKR7A2 AKTIP ALAD ALDH1A1 ALDH3A2 ALDH5A1 ALDH6A1 ALDH9A1 ALKBH3 ALKBH7 ALS2CL AMFR AMMECR1L AMOTL1 ANAPC13 ANAPC2 ANAPC7 ANGEL1 ANGEL2 ANK3 ANKH ANKMY2 ANKRD10 ANKRD11 ANKRD13C ANKRD16 ANKRD46 ANKRD50 ANO10 ANP32A AOF1 AP2A1 AP4S1 APBB3 APC APCDD1 APEH APH1B APOA1BP APOE APPL2 AQP1 ARAP3 ARF5 ARFGEF1 ARFRP1 ARHGAP18 ARHGAP22 ARHGEF1 ARHGEF10L ARHGEF12 ARHGEF17 ARHGEF18 ARHGEF3 ARID2 ARIH2 ARL2BP ARL3 ARL4C ARL4D ARMC1 ARMCX5 ARNT ARPC5L ARRB1 ARRDC2 ARRDC3 ART4 ASB1 ASCC1 ASH1L ASNA1 ASNSD1 ASPSCR1 ATAD2B ATF2 ATG10 ATG16L1 ATG2A ATG9A ATP11C ATP1B1 ATP5A1 ATP5B ATP5C1 ATP5D ATP5H ATP5SL ATP6V0D1 ATP9B ATRNL1 ATXN10 ATXN2 B3GALTL B3GAT3 B3GNT1 BACE1 BACH2 BAMBI BAT2L BBS2 BBS9 BCAM BCAR1 BCAS3 BCAT2 BCKDHA BCKDHB BCKDK BCL2L1 BCR BDH2 BICD2 BIVM BLCAP BLOC1S1 BMP2 BNIP1 BNIP3L BOK BOLA3 BPGM BPHL BPTF BRD1 BRD3 BRD8 BRE BRF1 BRI3BP BRP44 BRPF3 BRWD1 BSDC1 BSG BTBD6 BTBD7 BTF3L4 BTRC C10orf104 C10orf119 C10orf58 C10orf84 C11orf54 C11orf60 C11orf67 C11orf68 C11orf71 C11orf75 C12orf10 C12orf41 C12orf57 C13orf37 C14orf102 C14orf147 C14orf2 C15orf17 C15orf61 C16orf13 C16orf14 C16orf58 C16orf68 C16orf72 C17orf39 C17orf58 C17orf61 C17orf63 C17orf90 C17orf95 C18orf19 C18orf22 C19orf2 C19orf36 C19orf42 C19orf43 C19orf50 C19orf63 C19orf70 C1orf122 C1orf124 C1orf128 C1orf156 C1orf198 C1orf2 C1orf26 C1orf43 C1orf53 C1orf63 C1orf91 C1orf93 C1QTNF7 C20orf108 C20orf11 C20orf112 C20orf27 C20orf30 C20orf74 C21orf33 C22orf13 C22orf39 C2orf28 C2orf42 C2orf43 C2orf76 C3orf10 C3orf23 C3orf33 C3orf63 C4orf29 C4orf34 C5orf13 C5orf24 C5orf33 C5orf34 C5orf51 C6orf120 C6orf130 C6orf136 C6orf225 C6orf57 C6orf64 C6orf72 C7orf10 C7orf41 C7orf47 C7orf59 C8orf4 C8orf40 C9orf125 C9orf126 C9orf150 C9orf16 C9orf21 C9orf23 C9orf69 CAB39L CABC1 CABLES2 CACNB3 CALHM2 CAMK1 CAMK2N1 CAMSAP1 CARHSP1 CASD1 CAST CAT CAV1 CAV2 CBS CBX7 CC2D2A CCBL1 CCDC104 CCDC111 CCDC28A CCDC59 CCDC6 CCDC85B CCDC91 CCNDBP1 CCNG2 CCNI CCNL2 CCNT1 CCNY CCS CD163 CD1D CD79A CD81 CD82 CD99 CD99L2 CDADC1 CDC25B CDC2L6 CDC37 CDC37L1 CDC42BPA CDC42BPB CDC42EP1 CDC42EP4 CDH2 CDIPT CDK10 CDK9 CDKN1B CDR2 CENPB CENPV CEP63 CERCAM CERK CFL2 CHAC2 CHCHD7 CHD2 CHD3 CHD4 CHD6 CHD7 CHDH CHKB CHM CIRBP CIT CITED2 CIZ1 CLCN3 CLCN4 CLDN12 CLIP3 CLK1 CLK2 CLK3 CLK4 CLOCK CLSTN1 CLU CMAH CMAS CMBL CNNM3 CNPY3 CNRIP1 COBLL1 COBRA1 COCH COG3 COG4 COL18A1 COL4A5 COMMD4 COPZ2 COQ2 COQ9 COX4I1 COX6C COX7A1 COX7A2L COX7C COX8A CPM CPOX CPSF1 CPT2 CRAT CREBBP CREBZF CREG1 CRIP2 CROT CRTC3 CRYZ CSAD CSDE1 CSGALNACT1 CSK CSNK1G2 CSNK1G3 CST3 CSTF2T CTBP1 CTCF CTDSP1 CTDSPL CTNNBIP1 CTR9 CTSF CTSH CUL3 CUL5 CUL7 CUX1 CXCL12 CXCR4 CXXC5 CYB5A CYB5D2 CYB5R3 CYBASC3 CYHR1 CYP2E1 CYP39A1 CYTH2 CYTSA D2HGDH DAG1 DALRD3 DAP DBP DBT DCI DCPS DCTN1 DCTN2 DCUN1D2 DCXR DDB1 DDB2 DDX3Y DDX6 DECR2 DEDD2 DENND4A DEPDC6 DEPDC7 DERA DGAT1 DGCR2 DGCR6 DGKA DGUOK DHRS1 DHRS11 DHX32 DHX36 DHX40 DICER1 DIP2A DIP2C DIRC2 DLC1 DLG1 DLGAP4 DMXL1 DMXL2 DNAJB12 DNAJB14 DNAJB2 DNAJC19 DNAJC30 DNAL4 DNM1 DNMBP DOCK6 DOCK8 DOCK9 DOK3 DOK4 DOLK DPH5 DPT DRG1 DSEL DVL1 DYM DYNC1LI2 DYNLRB1 DYNLT3 DYRK2 E4F1 EBPL ECH1 ECHDC3 ECHS1 ECM1 EEF1A1 EEF1D EEF2 EEF2K EFCAB4A EFNB2 EGLN1 EHMT1 EI24 EIF1 EIF2AK1 EIF2AK3 EIF2C2 EIF3C EIF3F EIF3H EIF4A2 EIF4B EIF4EBP2 EIF5 ELL3 ELMOD3 ELOVL5 EML3 EMP2 ENDOG ENOX2 ENTPD4 EPAS1 EPB41 EPC1 EPHX1 EPM2AIP1 EPS15L1 ERBB2IP ERCC5 ETFB ETFDH ETHE1 EVI5 EXOC3 EXOC6 F5 F8A1 FADS1 FAF2 FAH FAHD1 FAHD2A FAM102A FAM103A1 FAM104A FAM107B FAM108B1 FAM110B FAM116A FAM120B FAM126B FAM134A FAM134B FAM134C FAM149B1 FAM158A FAM160A2 FAM160B1 FAM168A FAM168B FAM173A FAM173B FAM177A1 FAM36A FAM3C FAM43A FAM50A FAM53B FAM54B FAM69A FAM73B FAM82B FAM8A1 FAM98C FANCE FASN FASTKD1 FAU FBLN1 FBLN5 FBXL12 FBXL20 FBXL3 FBXL4 FBXO11 FBXO21 FBXO22 FBXO25 FBXO3 FBXO38 FBXO8 FBXO9 FBXW2 FBXW4 FBXW5 FBXW8 FCGRT FCHO2 FCHSD2 FDX1 FECH FGFR1OP FGFR1OP2 FHOD1 FHOD3 FIG4 FIS1 FKBP4 FKBP8 FKBP9 FKTN FLOT2 FMOD FNBP1 FNBP1L FNTA FOXJ2 FOXN3 FOXO1 FOXO3 FOXP1 FPGT FRMD6 FTO FUT11 FYCO1 FZD1 FZD6 FZR1 GAB1 GABARAP GABARAPL1 GABARAPL2 GAK GALNT1 GALNT11 GALNT2 GAMT GAS6 GATC GBA2 GBAS GCAT GCDH GCHFR GDI1 GGA1 GGA2 GGH GGNBP2 GIGYF1 GIT2 GLE1 GLO1 GLRX5 GLT8D3 GLTSCR2 GLUD1 GLUL GM2A GMCL1 GMPS GNA11 GNA12 GNAS GNB2 GNPDA2 GOLGA7 GOLGB1 GPAM GPATCH1 GPBP1L1 GPR116 GPR155 GPS1 GPSM1 GPSN2 GPX1 GPX4 GRAMD1A GRAMD4 GRAP GRHPR GRK6 GRLF1 GRPEL2 GRTP1 GSN GSTA4 GSTK1 GSTT1 GTF2I GUF1 GULP1 GZF1 H2AFV H6PD HABP4 HACL1 HADH HADHA HAGH HAGHL HBA2 HBP1 HDAC10 HDAC4 HDAC5 HDAC6 HEBP1 HECA HECTD1 HECTD3 HELZ HEMK1 HERC1 HERC2 HERPUD1 HERPUD2 HES1 HEXIM1 HHEX HIBADH HIGD2A HINT2 HINT3 HIPK1 HIST1H2BC HIST2H2BE HLTF HMBS HMG20B HMGCL HMGCS2 HMGN1 HMHA1 HNMT HNRNPH3 HNRNPU HNRNPUL1 HP1BP3 HPGD HPS4 HPS5 HRAS HS6ST1 HSD17B10 HSD17B11 HSD17B4 HSDL1 HSF1 HSPA12A HYI IAH1 ICMT IDH1 IDH2 IDH3B IDH3G IDS IFNAR1 IFRD2 IFT140 IFT80 IGF1 IGFBP2 IGFBP3 IGFBP4 IL11RA IL6R IL7R ILK ILKAP ILVBL IMPAD1 INO80B INPP5K INSR IP6K2 IPO8 IQSEC1 IREB2 IRS1 ISCA1 ISCA2 ISCU ITCH ITFG3 ITGA8 ITGAE ITGB5 ITM2A ITPR2 IVD JMJD8 JTB KANK2 KATNB1 KBTBD7 KCMF1 KCTD15 KCTD2 KHK KIAA0114 KIAA0141 KIAA0232 KIAA0240 KIAA0430 KIAA0467 KIAA0564 KIAA0922 KIAA1012 KIAA1143 KIAA1219 KIAA1370 KIAA1430 KIAA1539 KIAA1609 KIAA2018 KIF1B KIF1C KIN KLC4 KLF12 KLF3 KLF9 KLHDC2 KLHDC5 KLHL12 KLHL13 KLHL2 KLHL22 KLHL24 KLHL7 KLHL9 KMO KPNA1 KPTN KRCC1 KRR1 KYNU LACTB LACTB2 LAMB2 LANCL1 LDB1 LDLRAD3 LDLRAP1 LEAP2 LEMD2 LETMD1 LGR4 LIAS LIMCH1 LIMK2 LIMS2 LIN7C LLGL2 LMBR1 LMBRD1 LMCD1 LOXL1 LPCAT3 LPGAT1 LPHN2 LPIN1 LRBA LRIG1 LRIG2 LRP4 LRP6 LRRC57 LRRC58 LRRC8A LRRCC1 LSM14B LTBP2 LTBP3 LTBP4 LYRM2 LYRM4 LYRM5 MACF1 MACROD1 MADD MAF1 MAGI3 MAK10 MALAT1 MAN1A1 MAN2A2 MAN2B1 MANBAL MAOB MAP1LC3A MAP1LC3B MAP2K2 MAP2K5 MAP2K6 MAP3K1 MAP3K12 MAP3K4 MAP3K5 MAP3K7IP3 MAP4K2 MAP4K5 MAPK1 MAPK3 MAPK8 MAPKAP1 MARCH2 MARCH3 MARCH6 MARCH7 MARCH8 MARVELD1 MAST3 MBD6 MBNL1 MCAT MCCC1 MCRS1 ME1 MECP2 MED12 MED16 MEIS1 MEMO1 MEN1 MEPCE METTL7A MFAP1 MFAP5 MFF MFHAS1 MFNG MFSD6 MGAT4B MGEA5 MGLL MGP MGST3 MIB2 MICAL1 MICALL1 MICALL2 MID1IP1 MIF4GD MKNK2 MKRN1 MLH3 MLL3 MLL5 MLLT4 MLYCD MMD MMD2 MMGT1 MN1 MORC4 MORF4L1 MOSC2 MPDZ MPHOSPH8 MPND MPP6 MPPE1 MPRIP MPST MPV17 MRM1 MRPL24 MRPL30 MRPL48 MRPL9 MSL1 MSL2 MSRA MSRB2 MTERFD3 MTFR1 MTIF2 MTIF3 MTMR3 MTX3 MUM1 MUS81 MUT MUTED MUTYH MXD4 MXI1 MXRA8 MYH9 MYL6 MYL6B MYL9 MYLIP MYO18A MYO1B MYO1C MYO6 MYST1 MYST4 N4BP2L1 N6AMT1 NADSYN1 NAGA NANP NAP1L4 NAP1L5 NAPRT1 NARF NARG2 NAT12 NAV1 NBEAL1 NBR1 NCOA4 NCOR2 NCRNA00094 NCRNA00153 NDFIP1 NDRG3 NDST1 NDUFA2 NDUFA3 NDUFA4 NDUFA6 NDUFA7 NDUFAF2 NDUFB10 NDUFB11 NDUFS2 NDUFS7 NDUFS8 NDUFV1 NEDD4 NEK9 NELF NF2 NFIA NFIB NFIC NFS1 NICN1 NIPBL NIPSNAP1 NISCH NIT2 NKIRAS1 NLK NME3 NME4 NNT NOTCH3 NPTXR NR1D1 NR1D2 NR1H4 NR2C2 NR2F2 NR2F6 NR3C1 NRP1 NSUN4 NT5C3L NT5DC1 NUAK1 NUBPL NUCB1 NUDT16 NUDT16L1 NUDT21 NUDT3 NUDT4 NUDT6 NUMA1 NXF1 NXT2 OAZ1 OAZ2 OBFC1 OBFC2B OCEL1 ODZ3 OMA1 ORAI1 ORAI2 ORC5L ORMDL1 ORMDL3 OSBPL2 OSBPL5 OSBPL9 OSGEPL1 OTUD5 OXR1 PABPC1 PABPC4 PAF1 PAFAH1B1 PAICS PAIP2 PALLD PANK3 PAPOLG PAPSS1 PAPSS2 PARK7 PARP1 PATZ1 PBLD PBX1 PCBD1 PCBD2 PCBP4 PCCB PCIF1 PCMTD1 PCMTD2 PCNP PCNT PCYOX1 PCYOX1L PCYT1A PCYT2 PDCD2L PDCD4 PDCD6IP PDDC1 PDE7A PDF PDGFA PDHA1 PDHB PDK2 PDLIM2 PDPK1 PDSS2 PDZD8 PEPD PERP PET112L PEX1 PEX19 PEX26 PEX5 PEX7 PFDN5 PFKM PFN1 PGAP1 PGM2L1 PGP PGRMC1 PGRMC2 PHB2 PHF1 PHF13 PHF17 PHKB PHKG2 PHLDA3 PHLDB2 PHLPP PHPT1 PHYH PI4KA PIAS3 PIGP PIGX PIK3C3 PIK3R4 PINK1 PIP5K1C PJA1 PJA2 PKD1 PKD2 PKNOX1 PKP4 PLD3 PLEKHA1 PLEKHG2 PLEKHG3 PLSCR4 PLXNB2 PLXND1 PMF1 PMM1 PMVK PNKD POGZ POLG POLG2 POLR2I POLR2L POLR3G POLR3GL POMGNT1 POPDC3 POU2F1 POU6F1 PPAP2B PPAPDC2 PPARA PPCDC PPIL2 PPM1A PPM1B PPM1D PPM1F PPM1M PPOX PPP1CB PPP2R5A PPP2R5C PPP2R5D PPP2R5E PPP3CA PPTC7 PQBP1 PQLC1 PRCC PRDM2 PRDX2 PREPL PRKAB1 PRKAB2 PRKACB PRKAG1 PRKD3 PRKDC PRKRA PRKRIR PRMT2 PRPF39 PRPF8 PRPS2 PRPSAP1 PRPSAP2 PRSS1 PSEN2 PSENEN PTEN PTGES3 PTGFRN PTMS PTP4A2 PTP4A3 PTPLB PTPN11 PTPN14 PTPN3 PTPRB PTRF PTS PTTG1IP PUM1 PUM2 PURA PXMP3 PXMP4 PYGL PYROXD1 QDPR R3HDM2 RAB11B RAB1B RAB22A RAB33B RAB34 RAB3GAP1 RAB40B RAB5B RABAC1 RABEP2 RAF1 RALBP1 RALGPS2 RANBP10 RAPGEF1 RB1CC1 RBAK RBL2 RBM4B RBM5 RBMS3 RBMX RC3H2 RCAN2 RCAN3 RCCD1 RCHY1 RCN3 RCOR3 RDH10 RDH11 RDX RECK REEP3 RELL1 RERE RETSAT RFK RFWD2 RFX7 RFXAP RGL2 RGP1 RGS3 RHBDF1 RHOT2 RIC8A RIC8B RIN3 RIOK3 RMI1 RMND5A RMND5B RNASE1 RNASE4 RNF10 RNF11 RNF123 RNF130 RNF139 RNF145 RNF146 RNF166 RNF167 RNF169 RNF2 RNF40 RNF44 RNF5 RNPEPL1 ROGDI RP9 RPL18A RPL22 RPL5 RPL9 RPRD1A RPS15 RPS27 RPS9 RPUSD3 RRAGA RSC1A1 RSRC2 RUFY1 RXRB RYK S100A16 SACM1L SAFB2 SBK1 SBNO1 SC5DL SCAP SCAPER SCARA3 SCARB1 SCP2 SDF4 SDR39U1 SEC14L2 SEC16A SEC22C SEC24C SEC62 SELENBP1 SEMA3G SEMA5A SEMA6A SEPP1 SEPX1 SERAC1 SERINC1 SERINC3 SERTAD2 SESN1 SESN3 SETD2 SFRS18 SFRS2IP SFRS5 SFRS6 SFRS8 SFT2D3 SFXN2 SGMS1 SGPP1 SH2B1 SH3BGRL2 SH3BP5 SH3D19 SH3GLB2 SH3TC2 SH3YL1 SIAH1 SIDT2 SIGMAR1 SIPA1L1 SIPA1L2 SIRT1 SIRT3 SIRT5 SIRT7 SKI SKP1 SLC12A2 SLC14A1 SLC15A4 SLC16A7 SLC17A5 SLC20A2 SLC22A23 SLC22A4 SLC25A1 SLC25A10 SLC25A11 SLC25A16 SLC25A23 SLC25A3 SLC25A37 SLC25A39 SLC26A11 SLC27A4 SLC35A1 SLC35B3 SLC35E3 SLC36A2 SLC37A4 SLC39A3 SLC46A1 SLC46A3 SLC48A1 SLC4A2 SLC9A3R1 SLC9A6 SLTM SMAD4 SMAD7 SMARCA2 SMARCC2 SMARCD2 SMC6 SMEK2 SMUG1 SMURF2 SNAP47 SNAPIN SNN SNRK SNRNP200 SNRNP25 SNRNP48 SNRNP70 SNX21 SNX29 SNX30 SNX9 SOCS5 SOCS7 SOD1 SORD SORL1 SORT1 SOX18 SP1 SP3 SPAG7 SPATA7 SPIN1 SPOP SPOPL SPTA1 SPTAN1 SPTBN1 SREBF1 SREBF2 SRI SSBP3 SSFA2 SSH2 SSPN ST3GAL2 STAG1 STAG2 STARD10 STARD4 STARD9 STAT5B STIM1 STK25 STK38 STRADB STRN4 STUB1 STXBP6 STYX SUDS3 SULT1C2 SUOX SURF1 SUV420H1 SUV420H2 SVIL SYF2 SYNJ2BP SYNPO2 TACC1 TAF10 TAF13 TAOK1 TBC1D12 TBC1D17 TBC1D4 TBC1D5 TBC1D8 TBC1D9B TBCE TBCEL TBL1X TCEA3 TCEAL1 TCEAL8 TCEB2 TCF25 TCF7 TCP11L2 TCTA TCTEX1D2 TEF TENC1 TERF2IP TESK1 TEX261 TF TFAM TFB2M TFDP2 TGFBR1 TGFBR3 TGFBRAP1 TH1L THAP4 TIMP2 TK2 TLCD1 TLE2 TM9SF3 TMC6 TMCO3 TMEM106B TMEM115 TMEM134 TMEM135 TMEM14C TMEM150 TMEM160 TMEM18 TMEM19 TMEM204 TMEM205 TMEM218 TMEM30A TMEM42 TMEM5 TMEM57 TMEM63A TMEM64 TMEM66 TMEM80 TNIK TNK2 TNKS1BP1 TNPO3 TNRC6B TNRC6C TNS1 TNXB TOB1 TOM1L2 TOP2B TP53BP2 TPCN1 TPD52L1 TPP1 TPPP TPRG1L TPRKB TRAF3IP1 TRAK1 TRAK2 TRAPPC5 TRIM11 TRIM23 TRIM28 TRIM41 TRIP6 TRRAP TSC22D1 TSC22D3 TSEN34 TSHZ1 TSHZ2 TSN TSPAN12 TSPAN32 TSPAN9 TSPYL1 TSPYL2 TSPYL4 TST TTC14 TTC28 TTC3 TTC4 TTC7A TTC8 TTLL7 TTPAL TTYH3 TULP3 TULP4 TUSC4 TXNDC15 TXNDC16 TXNIP TXNL4A TXNRD2 UBAC1 UBAC2 UBAP2 UBE2B UBE2D2 UBE2E2 UBE2E3 UBE2G1 UBE2H UBE2L3 UBE2O UBE2Q2 UBE3B UBL3 UBLCP1 UBP1 UBR2 UBR3 UBTF UBXN1 UBXN2A UBXN6 UCK1 ULK1 ULK2 UNC119B UNC45A UNC84A UNC84B UNK UNKL UPF3A UQCRC1 UQCRC2 UQCRH UROD UROS USE1 USF2 USP2 USP20 USP24 USP3 USP30 USP4 USP45 USP48 USP7 VAMP1 VAMP2 VAMP4 VAMP8 VANGL1 VEGFB VGLL4 VKORC1 VPS11 VPS13B VPS24 VPS28 VPS39 VPS41 VTI1B VWF WASL WBP2 WDR23 WDR26 WDR40A WDR45 WDR45L WDR51B WDR5B WDR6 WDR7 WDSUB1 WDTC1 WFDC1 WIPF2 WNT2 WWP1 XAB2 XPA XPC XPO7 XPR1 YAF2 YIPF4 YPEL3 YPEL5 YTHDF3 ZADH2 ZBTB20 ZBTB22 ZBTB24 ZBTB39 ZBTB4 ZBTB44 ZBTB9 ZC3H10 ZC3H11A ZC3H8 ZCCHC14 ZCCHC24 ZDHHC4 ZDHHC9 ZEB1 ZFAND1 ZFAND2B ZFAND6 ZFP36L1 ZFYVE21 ZFYVE27 ZHX3 ZMAT1 ZMAT3 ZMIZ1 ZMYM2 ZMYND11 ZNF12 ZNF148 ZNF187 ZNF219 ZNF238 ZNF250 ZNF260 ZNF275 ZNF318 ZNF329 ZNF367 ZNF398 ZNF445 ZNF496 ZNF512B ZNF592 ZNF598 ZNF623 ZNF652 ZNF653 ZNF740 ZNF747 ZNF768 ZNF770 ZNF827 ZNF862 ZNHIT2 ZNRF2 ZNRF3 ZSWIM7 ZYG11B ZZEF1

Trypanosoma cruzi Infection Induces a Global Host Cell Response in Cardiomyocytes Manque et al.2011

Misreguklated genes: 1600029D21RIK ABCA1 ABCG2 ACADM ACTB ADAM10 ADARB1 AHNAK ALDH1A1 AMPD3 ANGPTL4 ANLN ANXA1 ANXA3 APCDD1 APOBEC2 ARHB ARHGAP21 ARHJ ARL5A ART3 ATP11A ATP2A2 ATP5C1 ATP6AP2 BBP BC033609 BCKDHB BCL3 BDNF BGN BID BIRC5 BMP4 BMPR1A BRD1 C1D C1QR1 C330007P06RIK C330027C09RIK CAT CAV CCDC80 CCDC90B CCL2 CCL3 CCL5 CCL7 CCNB1 CCNG1 CCNI CCRN4L CCT7 CD164 CD44 CDC20 CEBPB CEBPD CISH CITED2 CLCA1 CLGN CLU CNN3 COL15A1 COL1A1 COL1A2 COL3A1 COL5A2 COL8A1 COPB2 COPS2 COX8A CPE CPEB2 CRCT1 CRIP1 CSF2 CSF3 CST3 CTSS CUGBP2 CXCL1 CXCL10 CXCL2 CXCL5 CYB5 CYP1B1 CYR61 DAG1 DNAJC3 DTR DUSP6 EIF4G2 EIF5A ELN EMP1 ENPP2 EPB4.1L1 EPRS F2R FABP3 FARSL FBLN2 FBN1 FGFR1 FHOS2 FKBP4 FMR1 FOSL1 G1P2 GABPA GADD45B GAS1 GBP2 GCH GHR GJA1 GLO1 GPR177 GPX7 GRP58 GTL2 GTL3 GUCY1B3 GYG1 H2AFV H2-T10 H2-T17 HDHD2 HIATL1 HIST1H2AB HMGN2 ICAM1 IDB2 IDE IDH1 IER3 IER5 IFI202B IFI204 IFIH1 IFIT1 IFIT2 IFIT3 IFNAR2 IGFBP2 IGFBP4 IGFBP5 IGTP IIGP2 IKEN CDNA 1190002N15 GENE IL11RA2 IL1A IL1B IL6 IMMP1 IMMT IQGAP1 IRF1 IRF5 IRF7 IRG1 ITFG1 ITGA5 ITM2A IVNS1ABP JUNB KDT1 KIF20A KIF5B KLF13 KPNA2 KRAS2 KRT1-19 KRT2-5 LAMB1-1 LATS2 LCN2 LIMS1 LIN7C LNX1 LONP2 LOX LRRFIP1 LTA4H LYZS MACF1 MADH1 MADH4 MATR3 MGLAP MKI67 MRPL16 MRPL49 MT1 MT2 MX2 MYH6 MYL1 MYL4 NAP1L1 NARS NCOA4 NDE1 NDEL1 NDN NDR2 NDUFB2 NDUFB4 NEDD4 NEDD9 NFKB2 NFKBIA NGFB NID2 NME3 NPN3 NR3C1 NUSAP1 OGN OSBPL1A OXCT P4HA1 PAIP2 PCID2 PCOLCE PDK3 PDLIM3 PDPN PECI PEG3 PFTK1 PHF17 PHLDA1 PHTF2 PIP5K1A PKP4 PLAUR PLS3 PMP22 PMPCB PON2 POSTN PPAP2A PPP1CB PROCR PRR13 PSAT1 PSMB5 PSME4 PTDSS1 PTGES PTGIS PTGS2 PTX3 PYGB RAD21 RBM18 RBP1 RELB RGS16 RIKEN CDNA 1110067D22 GENE RIKEN CDNA 1810030O07 GENE RIKEN CDNA 2810417H13 GENE RIKEN CDNA 3230401D17 GENE RNASE4 RYR2 SAA3 SAR1B SC4MOL SDFR1 SDPR SEC23A SELE SELP SEPT7 SERPINB1A SERPINE1 SERPINF1 SFRS1 SGCE SGCG SH3BGRL SLC38A4 SLMAP SMARCA2 SMC2L1 SMFN SNAP91 SOCS3 SORBS1 SPG21 SPRR1A SPS2 SSB SSPN STAG2 STMN1 STRAP STRN STS SYCP3 TCF21 TFDP1 TGFB1 TGFB3 THBD THBS2 THY1 TIMP1 TM2D2 TMCO1 TMED2 TMED7 TMEM59 TMEM97 TNFAIP3 TNFRSF6 TNIP1 TOP2A TOP2B TOPBP1 TRAM1 TRIM59 TSPYL4 TXNDC1 TYMS UBE2E1 USMG4 USP1 USP18 VAMP5 WTAP WWC1 YIPF5 YTHDF2 ZFP162 ZFP265 ZFP62 ZFP644

Regulation of the extracellular matrix interactome by Trypanosoma cruzi Cardenas et al, 2010

ECM interactome of early Trypanosoma cruzi infection ACHE APCS APP ATF7IP ATXNL2 BCAM BMP1 BTBD10 C3 CALR CCDC53 CD36 CD47 CFH COL1A1 COL3A1 COL5A1 COL6A1 COL7A1 CORO1A CSNK1A1 CSNK2A2 CTSG CUBN CYHR1 DAG1 DCN DHFR ELA2 ELN F2 FCGR2A FGA FN1 GEMIN4 HRG HSPG2 IGFBP5 ITGA1 ITGA2 ITGA3 ITGA4 ITGAV ITGB1 ITGB3 JAG1 KNG1 LAMA1 LAMA2 LAMA3 LAMA5 LAMB1 LAMB2 LAMB3 LAMC1 LAMC2 LAMC3 LGALS3 LGALS3BP LIM2 LRP1 LRP5 MATN2 MEP1A MMP2 MMP9 MUC7 MYOC NID1 NID2 NT5E ONECUT1 PDE1A PDGFB PLAT PLG PTPRF RPSA SAA1 SAA2 SCARB2 SIP1 SMAD2 SNAPIN SPARC SPP1 SUFU SV2A TFPI TGFB1 THBS1 TMPRSS6 TNFAIP6 TNFRSF11B TSC2 ZNF512B ZNF8

Transcriptomic alterations in Trypanosoma cruzi-infected cardiac myocytes Coeli dos Santos Goldenberg,2009

Upregulated ANKFY1 APOL9A ARHGEF2 AXUD1 BATF BOLA3 BST2 CCL5 CCL7 CKLF CKLFSF6 COMMD9 CRCT1 CRIPT CXCL1 CXCL10 CXCL16 DLP2 EEF1A1 EHD1 EIF5A GBP2 GPC1 GTPBP8 H2-D1 H2-T10 HSCB IFI204 IFIH1 IFIT1 IFIT3 IL13RA1 KCNMB1 LGALS3 BP MAFK MLANA NBL1 NCOA1 NMI NOL8 NPN3 NUPL1 OASL1 OLFR149 PAIP2B PAPPA PARP11 PARP14 PCDH19 PDDC1 PER1 PLEC1 PNPT1 POLR3 K PROCR PSMB8 PSMD3 RARSL RFC3 RIN1 RIPK2 ROD1 RSAD2 RWDD4A SAA3 SERPINA1A SLC10A2 SLC30A4 SPIRE1 SUCLA2 TAPBP TIMP1 TOR3A TREX1 TRIM30 UBN1 UBTF V1RA1 ZC3HDC1

Downregulated ACTN2 ADAMTS5 ANLN AQP1 AQP4 ARBP ARF4 BIRC1B BIRC5 BRP44L C1QA CALM1 CCDC80 CD109 CDH11 CNN1 COL4A2 COL6A1 CPE CTSS CXCL12 DOCK7 DRP2 DSCR1 DSCR1L1 DSTN ELN ETFDH FBLN5 FBN1 FKBP7 FST GJA1 GJC1 ITFG1 ITGA8 ITM2A JPH2 KCNE4 LAMC1 LYZS LZP-S MAD2L1 MCEE MDH1 MFAP4 MMP12 MMP23 MPV17 MYH10 MYH11 MYL2 NDUFS8 NID2 NIT1 NKX2-3 NUTF2 OLFR749 PCOLCE2 PMP22 POLA1 POLD4 PPP4R1 PRDX4 PRSS11 PSAP RHOA SDHB SLC1A6 SLC25A26 SORBS2 ST5 STAU2 TGFB2 TIMP3 TPARL TXNDC12 TXNDC16 WISP2 ZFP292

Cytokine-dependent and–independent gene expression changes and cell cycle block revealed in Trypanosoma cruzi-infected host cells by comparative mRNA profiling Costales et al, 2009

Upregulated: ADAR ADPRHL2 ANGPTL4 APOBEC3F APOBEC3G APOL1 APOL2 APOL3 APOL6 ATF3 ATP10A AVPI1 AXUD1 B3GNT2 B4GALT5 BAG1 BATF2 BCL2L13 BIRC4BP BRIP1 BST2 BTN3A1 BTN3A2 C17orf27 C1orf38 C20orf18 C4orf20 CARKL CASP1 CASP4 CASP7 CCDC75 CCDC86 CCL5 CCND3 CD274 CD55 CFB CH25H CHMP1B CNP COP1 DDX58 DTX3L EBF EHD4 EIF2AK2 ELF1 ENO2 EPSTI1 ESM1 FAM111A FAM46A FBXO6 FGF1 FGF2 FLJ11286 FLJ14213 FLJ20035 FLJ20647 FLJ31033 FLJ35390 FLJ36874 FMNL2 FMR1 FNDC3A FZD4 FZD8 G1P2 GBP1 GBP3 GMPR GOLPH2 GPRC5A GRM3 HERC5 HERC6 HES4 HIP1R HIST1H2AI HIST1H2AJ HK2 HLA-B HLA-C HLA-E HLA-F HLXB9 IBRDC3 ICAM3 IER2 IER3 IFI16 IFI27 IFI35 IFI44 IFI44L IFI6 IFIH1 IFIT1 IFIT2 IFIT3 IFIT5 IFITM1 IFNB1 IL11 IL15 IL15RA IL17RE IL6 IL7R IRF1 IRF7 ISG20 ISGF3G ITGA2 ITPR3 KIAA0082 KIAA1618 KIAA1754 KLF4 LAIR2 LAP3 LBA1 LGALS3BP LGALS9 LGP2 LOC126520 LOC129607 LOC283761 LOC400368 LOC400740 LOC440424 LOC441046 LOC441109 LRRC54 LY6E LYSMD2 MASTL MGC26356 MLKL MOV10 MSX1 MT1M MTMR3 MX1 MX2 MYD88 N4BP1 NCF2 NEDD1 NEF3 NMI NOD27 NP NR4A2 NT5C3 NUDCD1 OAS1 OAS2 OAS3 OASL OGFR PANK2 PARP10 PARP12 PARP14 PARP9 PBEF1 PCDH17 PFKFB3 PHACTR4 PHF11 PLAUR PLEKHA4 PLSCR1 PLXNA2 PMAIP1 PML PNPT1 PODXL PPM1K PRIC285 PRKD2 PRP2 PSMB8 PSMB9 PSME1 PTGS2 RAB27B RARRES3 RHEBL1 RICTOR RIN2 RIPK1 RIS1 RNF149 RSAD2 RSPO3 RTP4 SAMD9 SAMD9L SAMHD1 SECTM1 SIM2 SIPA1L3 SIX1 SLC15A3 SLC24A4 SLC25A22 SLC25A28 SLC7A5 SLFN5 SMARCA5 SP100 SP110 SPATA13 SPP1 SPSB1 SPTLC2 SSH2 STAMBPL1 STAT1 STAT2 STC1 STIM1 SYTL3 TAP1 TAP2 TDRD7 TGIF THBD TLR3 TMEM140 TMEM62 TNFAIP6 TNFSF10 TNFSF13B TREX1 TRIM14 TRIM21 TRIM22 TRIM25 TRIM26 TRIM38 TRIM5 TRIM56 TSNARE1 UBE1L UBE2L6 UNC93B1 USP18 WARS WDR71 XIST XRN1 ZBTB7A ZC3HAV1 ZCCHC2 ZFYVE26 ZNFX1

Downregulated ABCB6 ACO1 ADAMTS15 ADAMTS5 ADPN AFF3 ANK3 ARID5B ARMC9 ATXN1 BCL2L14 C11orf34 C21orf57 C4orf18 CASD1 CCDC75 CERK CIRBP CLN8 CYP51A1 DEPDC6 DIP13B DSCR1L1 EBF ELP4 f FAM101B FDPS FHL1 FKHL18 FLJ13576 FLJ37798 FN1 FNBP1L FZD2 GLS GREM2 HCFC1R1 HGF HMCN1 HMGCR HNRPA0 HTR2B INSIG1 KIAA0114 KRTAP1-5 LGR5 LMOD1 LOC116349 LOC134145 LOC221362 LOC285550 LOC389129 LOC440449 LOC441311 LPIN1 LUM MAF MCART1 MEOX2 METTL7A MGC52110 MYT1 NPM1 NT5DC2 OMA1 PBX1 PCDH9 PDE1A PDE4DIP PELI2 PHLDB2 PKP4 PPP2R2D PRKCA PRRT1 PRSS12 PSCDBP PTPN11 RAB40B RHOBTB1 RPIB9 SC4MOL SCD SESN3 SLC16A9 SLC7A11 SPATA7 STXBP4 TBL1XR1 TCF7L2 TDP1 THBS1 TLE4 TMEM107 TMEM35 TNFRSF10D TNFRSF11B TOX TP53INP1 TRPC6 TSLP WIG1

Trypanosoma cruzi triggers an early type I IFN response in vivo at the site of intradermal infection.Chessler et al, 2009

Genes down-regulated in skin from BALB/c mice after injection of: control versus Trypanosoma cruzi (strain Brazil).

ABCA1 ABTB2 ADH7 ADIPOR1 ADRA2B AGFG1 ALS2 ALS2CL ANK2 APOLD1 ARAP3 ARHGEF6 ARMCX2 ASPRV1 ASTN1 ATOH8 ATP6AP2 ATP8B4 BAG2 BBOX1 BCL6 BTBD3 C10orf120 C14orf119 C15orf43 C17orf28 C17orf70 C1QC C7orf73 C8orf42 CALB1 CALCRL CBFA2T3 CCR7 CD247 CD34 CD53 CD72 CD74 CDH9 CDYL2 CEP97 CERS6 CHCHD6 CHD7 CHIC1 CHML CHRNB4 CLPS CMA1 CSTA CTF1 CX3CL1 CYLC2 CYTL1 DDN DHX58 DNAH17 DTX3 DUSP23 DZIP1 EDA EDARADD EDNRB EIF2B4 EIF2C3 EMX1 EN2 EPHA5 EPHB3 ERBB2 FAM101B FAM102A FAM63B FARSB FAT1 FBXL16 FNTB FXR2 FXYD6 GAB2 GABRG3 GCGR GDF3 GGT5 GHRH GIPC1 GPR110 GTF2I HCK HES5 HLA-DQA1 HS2ST1 HTRA3 ICMT IHH ILDR1 INSC IRG1 ITGB5 KLRG1 LOC100288869 LOC388630 LRP1 LRP3 MBTD1 MDGA1 MEIG1 MFN1 MGRN1 MYLK3 NES NFE2L2 NOVA1 NPC2 NPNT OPRK1 OTOA PADI6 PARVA PAWR PCIF1 PCYT2 PDE3B PDE5A PDZD4 PDZRN4 PHF21A PIWIL4 POLR3F POU2AF1 PPP1R1A PPP6R2 PRKAB2 PRRX1 PSMD3 PTK7 PTPLA PXMP4 RAB13 RAB21 RAI1 RASSF7 RB1 RGS13 RGS5 RGS9BP RNF157 RWDD2B SATB1 SCG3 SCML4 SCNN1A SEMA4A SEMA4C SEMA6A SEMA6C SERINC2 SERPINA6 SIAH1 SLC12A8 SLC25A37 SLC30A8 SLC35F1 SLC4A3 SLC6A11 SPAG17 SPOCK1 STAU1 STIM1 STYXL1 TCF21 TEP1 TFAP2C TM6SF1 TMCO5A TMEM151A TMEM37 TNS3 TOMM34 TPD52L1 TPO TPPP3 TPSB2 TRIM7 UNC13B UNC5A USP25 USP7 UTF1 VAT1L VGLL1 VRTN WNT5B WWC2 YTHDF1 ZBTB43 ZFYVE28 ZIC2 ZNF474

> Genes up-regulated in skin from BALB/c mice after injection of: control versus Trypanosoma cruzi (strain Brazil). ACTR8 ADAMTS14 ALG14 ARHGAP6 ARL14 ATG12 AXIN2 BCAR3 BLNK BMF C1QTNF3 C20orf160 CBLL1 CCDC110 CCDC28A CCL22 CCNG2 CD40LG CD79B CDC42EP3 CDK3 CEACAM19 CNR1 CNST COL14A1 CSF3R CTCFL CYB561 DARS2 DCTN4 DDAH1 DDX24 DLEU7 DNAJC3 DSCR3 DSG4 EIF2C2 EIF4A2 ELN ETS2 EZH1 FAM102B FAM118A FAM32A FAM69A FBXO8 FCAMR FFAR1 FKBP1B FKBP6 GLYCAM1 GMEB2 GMFG HIST2H2BE HLA-G HOXD3 HRH1 HSD3B2 IDH3B IGF1 IGF2 INPP5A IQCE IRS4 ISM2 ITGAX KCNA1 KCNK9 KCNMB4 KCTD6 KDM5B KIAA1804 KLHL7 KRT72 KRT75 LRCH1 MAGEF1 MGAT1 MGST1 MMP17 MNS1 MYCT1 NAALADL2 NEBL NECAP1 NGLY1 NKX2-6 NR1D2 NRF1 OGFOD1 PATL1 PDGFRB PDZRN4 PGAP1 PKDREJ POLR1D POU2F1 PRDM14 PRIMA1 PRPH2 PTCH2 PTPN12 RAP2B S100A16 SCOC SLC25A37 SLC28A3 SLC38A3 SLIT2 SNX7 SOAT1 SOX10 ST3GAL1 ST6GALNAC5 STX18 STX8 SUGP1 SYNPR TACR1 TALDO1 TBCEL TMEM146 TMEM150A TMEM167B TTC29 TTLL7 WASF3 WDR45 WNT5A ZBTB24 ZDHHC15 ZNRF1

> Genes up-regulated in skin from BALB/c mice after injection of: control versus Trypanosoma cruzi (strain G). AADAT ACAA2 ACSL1 ADAMTS6 ADSL AFG3L2 AGA AHNAK ALPK2 ANKH ANTXR2 ANXA5 ANXA7 ARL10 ATP2B1 ATP5G3 ATP6V0D2 ATP6V1F AVEN BCL2L15 BLVRA C12orf12 C14orf45 C1orf43 C20orf85 C22orf28 C2orf43 C3orf80 C4orf51 C7orf57 CAMK1 CAPG CAPSL CCDC136 CCDC59 CD27 CD5 CD83 CDC16 CDC5L CDKN1C CNO CNPY2 COPS6 CTNNBL1 CTSW DENR DNAH11 DNAJC21 DUSP16 ECM1 EIF2S1 ENTPD1 EPHX1 ERLEC1 ETHE1 EXOSC5 EXT1 FABP1 FADS6 FAH FAM105B FAM124B FAM19A3 FAM36A FBXO6 FBXO7 FCF1 FFAR2 FKBPL GABARAPL1 GABPB2 GALR3 GANC GBP4 GFM2 GLIPR2 GPR83 GPRASP2 GPX1 HDGFRP3 HEY1 HNRPLL HOXA2 HS3ST1 HSD17B6 IER2 IFI35 IFT52 IKZF2 IL10 INTS12 INTS9 IRF6 ITGB1 ITGB8 KCNF1 KDM1B KERA KIAA1107 KIF5C KRTAP21-1 LAMC1 LCLAT1 LCP2 LSM10 LYRM7 MAF MAPKAPK3 MBD2 MDFIC MED8 METTL16 METTL20 MFNG MFSD4 MKI67IP MRPL19 MRPL21 MRPL55 MRPS10 MTHFS MXD3 MYC NDRG1 NDUFA8 NDUFB7 NHLRC2 NRP1 NSUN2 NT5E OMA1 PAM PANX1 PARD6G PCGF2 PCTP PDIA4 PFDN1 PHTF2 PLAGL1 PPM1L PPP1R14B PRAP1 PRG4 PRKCZ PROS1 PSTPIP2 PTER PTPN4 PVT1 RASGEF1B RBM8A REXO2 RNF217 RNH1 RORC RPS19BP1 RRAGD SAP18 SC5DL SCAMP1 SEC22B SELM SERAC1 SERHL2 SERPINF1 SFT2D2 SLA SLC22A15 SLC25A33 SMPDL3A SNED1 SOCS2 SSR1 STK38L SWAP70 TAGLN3 TBC1D4 TMEM11 TMEM154 TMEM158 TMEM185A TMEM65 TNFAIP8 TNFRSF13C TNFRSF18 TNFRSF4 TRIM45 TRMT6 TWSG1 UCHL3 UFL1 VTN XXYLT1 YWHAQ ZNF608 ZNF653 ZNF655 ZNF688

> Genes down-regulated in skin from BALB/c mice after injection of: control versus Trypanosoma cruzi (strain G). ABCD4 ABI2 ADAM29 AMOT ANXA1 ARAP1 ATP6V0A2 C17orf63 C9 CASC4 CCDC147 CEP112 CHST13 CLEC1A CLEC9A CLIP4 CMA1 CNTNAP4 COQ2 CORO6 CPEB2 CTNS CTSW CYFIP1 CYP11A1 DAPK3 DDX54 DHPS E2F3 EAF1 ETV1 FAM118B FAM160A1 FAM163A FBF1 FBXL4 GALNT10 GALP GBAS GHR GLTSCR1 GNG2 GPATCH3 GPR155 GPR173 GPR83 GUSB H6PD HDAC9 HGD HGS HTR3A IFNA13 IL12RB1 IL1RL1 ITPR3 KDELC2 LAP3 LAPTM5 LARGE LDLR LIPE LPCAT3 LRRC19 LRRC26 LUM LY6E LYPLAL1 MAPK8IP3 MAPKAP1 MBD2 MCOLN1 MED16 MLST8 MRAP MRPS25 MSR1 MTCH1 MTMR14 NAT1 NKG7 NUFIP1 NUPL2 P2RX7 PADI4 PHC3 PHLPP2 PI4KA POLM PPIA PRKAR2A PSMA2 PTGDS PTGIR PTGR1 RAB27A REG3A RGS18 RNF135 RORA SCARNA17 SCLY SEMA3E SEMA4D SERINC3 SF3A1 SFRP2 SLC25A13 SLC30A8 SNRPB2 SRD5A3 SRGAP3 STX2 TGFBRAP1 TM4SF5 TMEM150A TMEM67 TMPRSS11A TOX TRIM7 TRPC3 TRPC6 TTC23L UAP1 UBE2L3 VEGFC WAS ZIC5 ZYG11A

> Genes up-regulated in skin from 129S1 mice after injection of: control versus Trypanosoma cruzi (strain Y).

ABCA2 ABCA4 ABRA ADORA2B AIDA ALDH5A1 AMZ1 ARRDC4 ASPG BIRC7 BMP8B C17orf63 CAPN1 CD40 CLEC10A CLEC4G CNTN1 COL15A1 COL9A1 CPLX2 CRISPLD1 CRP CTU1 CXorf67 DPPA4 ENTPD1 EPHA10 ERN2 ESAM F2RL2 FAM170B FAM24A FAM43A FASN FBXL22 FBXO10 FOXJ2 GIF GNA15 GNPTG GPR143 GPR82 GRIN2C HHEX HNMT HPS6 IGFN1 IL23R INPP5J ITPKA IZUMO1 KATNAL2 KCNK7 KCNMB4 KIF13A KIF26B KIF5C KRT39 LRRC63 LY6G6C MDGA1 MED11 MEP1B MORN3 MOSC1 MSRB2 MYL9 NAF1 NBL1 NDUFS5 NEB NIPSNAP3A NPW NR6A1 NRN1L NRP1 OC90 PANX3 PARD6G PCLO PGLYRP4 PHEX PKHD1 PLA2G1B PLA2G4F PLCD3 PLIN5 PNPLA1 POU2F3 PRR15L PSMB11 PVRL4 RAPSN RARRES1 RASGRF1 RBM20 RBP7 RDH8 REPS1 RPRD1B RRS1 RTDR1 S100A11 S100A16 SCARA3 SDC4 SEMA6A SND1 SOHLH1 SRC SRY SYT5 TAAR9 TM4SF20 TMEM45B TNNI2 UBE2L3 UBQLN1 WFDC5 XCR1 ZAN ZDHHC1 ZER1 ZFP28 ZP3 ZSCAN29

> Genes down-regulated in skin from 129S1 mice after injection of: control versus Trypanosoma cruzi (strain Y).


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Last update: November 12, 2016