Host proteins used by Candida
Albicans during its life cycle.
If you know of other direct interactions,
(or corrections) please
with Pubmed ID, gene symbol/accession number and viral interacting
protein. Thank you.
ADAM17 ADAM metallopeptidase domain 17 (Tace) : VAMP3, ADAM17
and STX4 incolved in the movement of TNF to the phagosomal cup during
C.Albicans phagocytosis Murray
et al, 2005
AKT1 v-akt murine thymoma viral oncogene homolog 1 : Fungal secreted
aspartyl proteases induced Akt activation and phosphorylation of
IKBa, which mediates translocation of NFKB1 into the nucleus in
monocytes Pietrella
et al, 2010.
ALOX5 arachidonate 5-lipoxygenase: macrophages infected with Candida
albicans, Aspergillus flavus or Aspergillus fumigatus or treated
with Curdlan, a selective agonist of pattern recognition receptor
for fungi Dectin-1, displays increased expression of ALOX5, ALOX15
and PTGS2 Karnam
et al, 2015.
APOBEC3F apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like
3F: Candida albicans enhanced the production of the CCR5-interacting
chemokines CCL3, CCL4, and CCL5, and stimulates the production of
interferon-a and the restriction factors APOBEC3G, APOBEC3F, and
tetherin (BST2) in macrophages Rodriguez
et al, 2013.
APOE – apolipoprotein E: C.albicans growth enhanced in ApoE
-/- plasma: depletion of lipoproteins from plasma resulted in a
significant seven- to tenfold increase in C. albicans growth Vonk
et al, 2004
APOH apolipoprotein H: reduces Kupffer cell Candida albicans phagocytosis
index and killing score Gomes
et al 2002
APP amyloid precursor protein: beta-amyloid is an antimicrobial
peptide with activity against C.Albicans Socsia
et al, 2010
Arachidonic acid: During infection, arachidonic acid is released
from host phospholipids, leading to the production of host and yeast
derived prostaglandin E(2) . This stimulates yeast hyphal formation,
is immunomodulatory and causes cell damage during infection Ells
et al, 2012.
AREG amphiregulin: peptides derived from HBEGF, amphiregulin,
hepatocyte growth factor, PDGF-A and PDGF-B, as well as various
FGFs are antimicrobial and antifungal Malmsten
et al, 2007
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta: Protein levels
increased in infected mouse macrophages Martínez-Solano
et al, 2006
ATG5 autophagy related 5: Disruption of host autophagy in vitro
by RNA interference against ATG5 decreased the phagocytosis of C.
albicans Nicola
et al, 2012
ATG7 autophagy related 7 : Lack of ATG7 attenuates host resistance
against Candida Kanayama
et al, 2015
BCL10 B-cell CLL/lymphoma 10: hyphae stimulation induces CARD9
association with Bcl10, an adaptor protein that functions downstream
of CARD9 and is also involved in C. albicans-induced NF-kappaB activation
Bi
et al, 2010
BDKRB1 bradykinin receptor B1: Kininogen degrading secreted aspartyl
proteases from C.Albicans produve bradykinins capable of stimulating
BDKRB1 and -2 Rapala-Kozik
et al, 2010
BST2 bone marrow stromal cell antigen 2 (Tetherin): Candida albicans
enhanced the production of the CCR5-interacting chemokines CCL3,
CCL4, and CCL5, and stimulates the production of interferon-a and
the restriction factors APOBEC3G, APOBEC3F, and tetherin (BST2)
in macrophages Rodriguez
et al, 2013.
BTK Bruton agammaglobulinemia tyrosine kinase: BTK and Vav1 contribute
to Dectin1-dependent phagocytosis of Candida albicans in macrophages
Strijbis
et al, 2013
C3 – complement component 3: Fungal Pra1 binds to fluid-phase
C3 and blocks cleavage of C3 to C3a and C3b Luo
et al, 2010
C4BPA – complement component 4 binding protein, alpha: Binds
to C.Albicans Pra 1 Luo
et al, 2011
C5 complement component 5: C5a is a critical mediator in human
blood during C. albicans infection.Hünniger
et al, 2014
CALCA calcitonin-related polypeptide alpha: Procalcitonin decreased
both phagocytic and candidacidal activity of polymorphonuclear leukocytes
Pincíková
et al, 2005
CARD9 caspase recruitment domain family member: mediates Dectin-1-induced
ERK activation by linking Ras-GRF1 to H-Ras for antifungal immunity
Jia et al, 2014.
CASP1 – caspase 1, apoptosis-related cysteine peptidase:
Sap2 and Sap6 fungal proteins trigger IL1B and IL18 production through
inflammasome activation, via NLRP3 and caspase-1 activation in monocyte-derived
macrophages and dendritic cells Pietrella
et al, 2013
CASP3 caspase 3: CASP3 and CASP9 involved in C.albicans induced
apoptosis in oral epithelial cells Villar
et al, 2012
CASP8 caspase 8, apoptosis-related cysteine peptidase : A strong
requirement for CR3 and caspase-8 also was found for NLRP3-dependent
IL-1ß production in response to heat-killed C. albicans Ganesan
et al, 2008.
CASP9 caspase 9: CASP3 and CASP9 involved in C.albicans induced
apoptosis in oral epithelial cells Villar
et al, 2012
CCL3, CCL4,TNF, IL8 and CD83 upregulated by C.Albicans in monocytes:
RGS1, RGS2, RGS16, DSCR1, CXCL2, EGR3, FLT4, and TNFAIP6 were also
up-regulated in response to C. albicans, whereas CCR2 and NCF2 were
among the genes down-regulated Barker
et al, 2005
CCL5 chemokine (C-C motif) ligand 5 : Candida albicans enhanced
the production of the CCR5-interacting chemokines CCL3, CCL4, and
CCL5, and stimulates the production of interferon-a and the restriction
factors APOBEC3G, APOBEC3F, and tetherin (BST2) in macrophages Rodriguez
et al, 2013.
CCL18 chemokine (C-C motif) ligand 18 : selectively down-regulated
in dendritic cells during the maturation process induced by LPS,
TNF, CD40 ligand, Staphylococcus aureus Cowan I, Candida albicans,
and influenza virus.
CCL20 has antimicrobial effects on Escherichia coli, Pseudomonas
aeruginosa, Moraxella catarrhalis, Streptococcus pyogenes, Enterococcus
faecium, Staphylococcus aureus, and Candida albicans: CXCl2/growth-related
ß (Groß), CXCL10/IP-10, CXCL11/I-TAC, CXCL12/SDF-1a,
CCL11/eotaxin, and CCL13/MCP-4 also demonstrated low anti-C. albicans
activityYang
et al, 2003.
CCL28 chemokine (C-C motif) ligand 28 : CCL28 has potent antimicrobial
activity against Candida albicans, Gram-negative bacteria, and Gram-positive
bacteria Hieshima
et al, 2003.
CCR1, CCR5, CCR7, and CXCR5 chemokine receptor upregulated in
human monocytes exposed to C.Albicans: IL15, IL13RA1, and CD14 were
suppressed during the 18-h exposure to C. albicansKim
et al, 2005
CD5 – CD5 molecule: the CD5 ectodomain binds to and aggregates
fungal cells (Schizosaccharomyces pombe, Candida albicans, and Cryptococcus
neoformans) but not to Gram-negative (Escherichia coli) or Gram-positive
(Staphylococcus aureus) bacteria Vera
et al, 2009.
CD28:mice are incapable of resistance to reinfection. in CD86
or CD28-deficient mice Montagnoli
et al, 2002
CD33 My9, a monoclonal antibody to CD33 binds to C.Albicans (antigen
mimicry) Mayer
et al, 1990
CD36 – CD36 molecule (thrombospondin receptor): SCARF1 and
CD36, mediate host defense against Cryptococcus neoformans and Candida
albicans Means
et al, 2009
CD40 CD40 molecule, TNF receptor superfamily member 5 : absence
of CD40/CD40LG interactions results in increased susceptibility
to disseminated infection with C. albicans through decreased NO-dependent
killing of Candida by macrophages Netea
et al, 2002.
CD47: cd47-/- mice on a C57BL/6 background showed significantly
increased morbidity and mortality following Candida albicans infection
Navarathna
et al, 2015
CD69 up-regulation splenic B and T cells of C57Bl/6 mice after
administration of lipopolysaccharide or microbial immunosuppressive/mitogenic
proteins produced by C. albicans Vilanova
et al, 1996
CD80 Dendritic cells stimulated by C. albicans and A. fumigatus
induced DC maturation by increasing CD80 and CD86 co-stimulatory
molecules Fidan
et al, 2014
CD83 upregulated in THP-1 cells in response to C.Albicans Barker
et al, 2005
CD86: mice are incapable of resistance to reinfection. in CD86
or CD28-deficient mice Montagnoli
et al, 2002 Farnesol (secreted by C.Albicans) enhanced the expression
of activation markers on monocytes (CD86 and HLA-DR) and neutrophils
(CEACAM8 and ITGAM): CD1a, CD83, CD86, and CD80 were significantly
reduced Leonhardt
et al, 2015
CD207 (langerin) binds to a variety of Candida and Saccharomyces
species and weakly to cryptocci
De Jong et al, 2010
CDC42 cell division cycle 42: Expression of dominant-negative
Rac1 or Cdc42 eliminated C albicans- mediated ERK phosphorylation
and phagocytosis and granule migration toward the ingested microbes
Zhong
et al, 2003
CDH1 – cadherin 1, type 1, E-cadherin (epithelial): Fungal
Als3 required for C. albicans to bind to multiple host cell surface
proteins, including N-cadherin on endothelial cells and E-cadherin
on oral epithelial cells Phan
et al, 2007.
CDH2 – cadherin 2, type 1, N-cadherin (neuronal): mediates
endocytosis of Candida albicans by endothelial cells Phan
et al, 2005
CEBPB CCAAT/enhancer binding protein (C/EBP), beta: defective
production of bioactive IL12 and the impaired Th1 responses of C/EBPbeta-deficient
mice to Candida albicans infection Gorgoni
et al, 2002
CERS3 ceramide synthase 3: Mutant skin in CRES3 knockout mice
is prone to Candida albicans infection Jennemann
et al, 2012
CFHR1 complement factor H-related 1: Binds to C.Albicans Meri
et al, 2013
CFL1 cofilin 1 (non-muscle) : PTEN directly activates the actin
depolymerization factor cofilin-1 during PGE2-mediated inhibition
of phagocytosis of fungi Serezani
et al , 2012.
CHGA chromogranin A: Peptide derivatives have antifungal activity
(See
Refseq)
CHI3L1 chitinase 3 like 1: Promotes C.Albicans killing Gao
and Yu, 2015
CLEC4D C-type lectin domain family 4 member D (Dectin 3): Dectin-3
and Dectin-2 form a heterodimeric pattern-recognition receptor for
host defense against fungal infection Zhu
et al, 2013
CLEC4E C-type lectin domain family 4 member E: essential component
of the innate immune response to Candida albicans Wells
et al, 2008
CLEC6A C-type lectin domain family 6 member A (Dectin 2) : pattern
recognition receptor for fungi that couples with the Fc receptor
gamma chain to induce innate immune responses Sato
et al, 2006.
CLEC7A – C-type lectin domain family 7, member A (Dectin
1) : binds fungal glucans and induces innate immune responses to
fungal pathogens Adams
et al, 2008.
CLTA clathrin, light chain A : host E-cadherin, clathrin, dynamin
and cortactin accumulate at sites of C. albicans internalization
Moreno-Ruiz
et al, 2009
COLEC11 – collectin sub-family member 11: complex formation
between recombinant collectin-11 and recombinant MASP-2 on Candida
albicans leads to deposition of C4b Ma
et al, 2013
Copper: C.Albicans has a copper uptake system and host copper
levels modify its ability to deal with superoxide radicals Li
et al,2015
CRP C-reactive protein, pentraxin-related: associated with fungal
biofilms Nett
et al, 2015
CSF2 colony stimulating factor 2 (granulocyte-macrophage): epithelial
expression stimulated by C.Albicans Schaller
et al, 2002
CSF3 colony stimulating factor 3: 3 days after Candida infection
increased numbers of granulocyte-macrophage and macrophage progenitors
were observed in the bone marrow of CSF3-deficient mice Basu
et al, 2000
CSF1R colony stimulating factor 1 receptor : Downregulated during
monocytes to iDC differentiation by farnesol ( a compound secreted
by C.Albicans) Leonhardt
et al, 2015
CTLA4 cytotoxic T-lymphocyte-associated protein : IDO activity
was induced at sites of infection as well as in dendritic cells
and effector neutrophils via IFNG and CTLA4-dependent mechanisms
Bozza et al, 2005.
CTTN cortactin: host E-cadherin, clathrin, dynamin and cortactin
accumulate at sites of C. albicans internalization Moreno-Ruiz
et al, 2009
CXCL13 chemokine (C-X-C motif) ligand 13 : The prophylactic provision
of micafungin prior to Candida albicans infection was characterized
by an increase in the proinflammatory cytokines CXCL13 and SPP1
Fuchs
et al, 2016
CX3CR1 chemokine (C-X3-C motif) receptor 1(Fractalkine receptor):
CX3CR1-dependent renal macrophage survival promotes Candida control
and host survival Lionakis
et al, 2013.
CXCL10 (IP10): Candida albicans induced IL4, CCL22, IFN-gamma
and IP10 secretion in peripheral blood mononuclear cells Kanda
et al, 2002
DEFB4A – defensin, beta 4A: C. albicans induces upregulation
of DEFB4A and DEFB103B in polymorphonuclear leukocytes Steubesand
et al, 2009
DEFB103B – defensin, beta 103B: C. albicans induces upregulation
of DEFB4A and DEFB103B in polymorphonuclear leukocytes Steubesand
et al, 2009
DEFB114 defensin beta 114: antimicrobial against C.Albicans Yu
et al, 2013
DMBT1 – deleted in malignant brain tumors 1: inhibits Candida
albicans-induced complement activation Reichhardt
et al, 2012
DNM2 dynamin 2: host E-cadherin, clathrin, dynamin and cortactin
accumulate at sites of C. albicans internalization Moreno-Ruiz
et al, 2009
DSG2 desmoglein 2 Levels of occludin, E-cadherin, and desmoglein-2
reduced by C.Albicans in human intestinal epithelial monolayers
Frank
and Hostetter, 2007
EEA1 – early endosome antigen 1L : C. albicans-containing
endosomes transiently acquir early endosomal marker EEA1 Zhao
and Villar, 2011
EGFR – epidermal growth factor receptor: EGFR and ERBB2
signaling mediate epithelial cell invasion by Candida albicans during
oropharyngeal infection Zhu
et al, 2012.
EIF3F eukaryotic translation initiation factor 3 subunit F: Protein
levels decreased in infected mouse macrophages Martínez-Solano
et al, 2006
ERBB2 – v-erb-b2 erythroblastic leukemia viral oncogene
homolog 2, neuro/glioblastoma derived oncogene homolog (avian):
EGFR and ERBB2 signaling mediate epithelial cell invasion by Candida
albicans during oropharyngeal infection Zhu
et al, 2012.
F2 coagulation factor II (thrombin): activated by Candida proteinases
Kaminishi
et al, 1994
F2R coagulation factor II (thrombin) receptor: Inflammation was
promoted by F2R and F2RL1 activation in response to Candida Moretti
et al, 2008
F2RL1 coagulation factor II (thrombin) receptor-like 1 : Inflammation
was promoted by F2R and F2RL1 activation in response to Candida
Moretti
et al, 2008
F10 coagulation factor X: converted to the active form (Xa) by
both Candida and Pseudomonas proteinases Kaminishi
et al, 1994
F12 coagulation factor XII (Hageman factor): high-molecular-mass
kininogen (KNG1), F12 ) and prekallikrein (PPK) - adhere to candidal
cells Seweryn
et al, 2015
FAS Fas-FasLG interactions are involved in host defense against
lethal infection with Candida albicans Netea
et al, 1999
FASLG Fas ligand (TNF superfamily, member 6): Candida albicans
up-regulates the Fas-L expression in liver Natural Killer and Natural
Killer T cells Renna
et al, 2015.
FCAR antibodies directed to either FcgammaRI (CD64) or FCAR (CD89)
on human PMNL effectively enhanced both phagocytosis and killing
of C. albicans in vitro van
Spriel et al 1999
FCER1G Fc receptor, IgE, high affinity I, gamma polypeptide :
CLEC6A pattern recognition receptor for fungi couples with the Fc
receptor gamma chain to induce innate immune responses Sato
et al, 2006.
FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64):
FcgammaRI initiates potent anti-C. albicans immunity van
Spriel et al, 2001
FCGR3A Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
and FCGR3B: Innate immune receptors such as CD16, as well as the
adhesion marker NCAM1 (CD56) or immunoreceptor tyrosine-based activating
motif (ITAM)-bearing receptors such as NCR1 (CD335) and KLRK1 (CD314)
were down-regulated on natural killer (NK) cells after interaction
with C.Albicans Voight
et al, 2014.
FOS – FBJ murine osteosarcoma viral oncogene homolog : C.
albicans activates NF-kappaB and AP-1 (FOS)in OE21 cells Steubesand
et al, 2009
FUT7 fucosyltransferase 7 (alpha (1,3) fucosyltransferase): the
phagocytic activity in FUT7 -/- mice was significantly reduced Bartunková
et al, 2000.
GAL galanin/GMAP prepropeptide: GMAP has growth-inhibiting activity
against C. albicans and inhibits the budded-to-hyphal-form transition
Rauch
et al, 2007
GAPDH glyceraldehyde-3-phosphate dehydrogenase :a peptide derived
from human GAPDH has antimicrobial activity Swidergall
and , Ernst 2014
GAST Gastrin: stimulates neutrophil function, including C.Albicans
ingestion De
la Fuente et al, 1993
Glutathione: Candida albicans lacks the ability to survive within
its mammalian host in the absence of endogenous glutathione biosynthesis
Desai
et al, 2011
GSK3B glycogen synthase kinase 3 beta : infection of macrophages
with C. albicans, A. flavus, and A. fumigatus induced robust activation
of WNT5A signaling and increased expression of PIAS-1 and SOCS-1
and GSK3B phosphorylation Trinath
et al, 2014.
GUSB glucuronidase, beta :Released by macrophages, with MPO, in
response to C.Albicans Maródi
et al, 1991
Haemin and hemoglobin (HBA1 HBA2 HBB HBD HBE1 HBG1 HBG2) are used
by C.Albicans to scavenge host iron Weissman
et al, 2008 Haptoglobin (HP) or myoglobin (MB) may also be used
Han,
2005
HAMP hepcidin antimicrobial peptide: induced by heat-killed Candida
albicans Armitage
et al, 2011
HBEGF heparin-binding EGF-like growth factor: peptides derived
from HBEGF, amphiregulin, hepatocyte growth factor, PDGF-A and PDGF-B,
as well as various FGFs are antimicrobial and antifungal Malmsten
et al, 2007
HGF hepatocyte growth factor (hepapoietin A; scatter factor):
peptides derived from HBEGF, amphiregulin, hepatocyte growth factor,
PDGF-A and PDGF-B, as well as various FGFs are antimicrobial and
antifungal Malmsten
et al, 2007
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix
transcription factor): pharmacologic activation of colonic Hif1a
induces LL-37 expression and results in a significant reduction
of C. albicans GI colonization in mice Fan
et al, 2015
HLA-DRB1 T cell epitopes of Candida albicans secretory aspartyl
proteinase 2 bind to HLA-DRB1 Tongchusak
et al, 2008
HMOX1 heme oxygenase 1: cell wall beta-glucan from C. albicans
stimulates pulmonary HMOX1 Inoue
et al, 2009
HRAS Harvey rat sarcoma viral oncogene homolog: CARD9 mediates
Dectin-1-induced ERK activation by linking Ras-GRF1 to H-Ras for
antifungal immunity
Jia et al, 2014.
HSPA1A heat shock protein family A (Hsp70) member 1A : Downregulated
in macrophages by C.Albicans Kitahara
et al, 2015
HSPA5 heat shock protein family A (Hsp70) member 5 : Protein levels
increased in infected mouse macrophages Martínez-Solano
et al, 2006
HSPA8 heat shock protein family A (Hsp70) member 8 : Protein levels
decreased in infected mouse macrophages Martínez-Solano
et al, 2006
HSPA9 heat shock protein family A (Hsp70) member 9: Protein levels
decreased in infected mouse macrophages Martínez-Solano
et al, 2006
HSPD1 heat shock protein family D (Hsp60) member 1: Protein levels
decreased in infected mouse macrophages Martínez-Solano
et al, 2006
HSP90B1 – heat shock protein 90kDa beta (Grp94), member
1: The fungal invasin Als3 binds to HSP90B1,expressed on the surface
of brain endothelial cells
Liu et al, 2011
HTN3 – histatin 3: Salivary protein that binds to C. albicans
spheroplasts Xu
et al, 1999
HVCN1 hydrogen voltage gated channel 1: HVCN1 deficient mice exhibited
more severe lung inflammation after intranasal Candida albicans
infection than WT mice Okochi
et al, 2015
IDO1 indoleamine 2,3-dioxygenase 1 : IL-22 and IDO1 are crucial
in balancing resistance with tolerance to Candida infection De
Luca et al, 2015
IFIH1 interferon induced, with helicase C domain 1: involved in
the host defense against Candida infections Jaeger
et al, 2015.
IFNAR1 interferon (alpha, beta and omega) receptor 1 : C.Albicans
invasiveness is protected in IFNAR1 knockout mice Majer
et al, 2012.
IFNB1 interferon, beta 1, fibroblast: Dectin-1-induced IFN-ß
production , by C. Albicans, required the tyrosine kinase Syk and
the transcription factor IRF5 del
Fresno et al, 2013
IFNG interferon, gamma: Candida albicans induced IL4, CCL22, IFN-gamma
and IP10 secretion in peripheral blood mononuclear cells Kanda
et al, 2002
IGF1 insulin like growth factor 1: IGFI augmented the Polymorphonuclear
neutrophilic leukocyte phagocytosis of both immunoglobulin G-opsonized
Staphylococcus aureus and complement-opsonized Candida albicans
Bjerknes
and Aarskog, 1995
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells,
kinase beta: Involved in fungal activation of chemokine expression
in endothelial cells Müller
et al, 2007
IL1A interleukin 1 alpha: IL1A and IL1B are crucial for host defense
against disseminated candidiasis Vonk
et al, 2006
IL1B – interleukin 1, beta: Sap2 and Sap6 fungal proteins
trigger IL1B and IL18 production through inflammasome activation,
via NLRP3 and caspase-1 activation in monocyte-derived macrophages
and dendritic cells Pietrella
et al, 2013
IL1RN interleukin 1 receptor antagonist: NLRP3 Inflammasome Activity
during Candida Infection Is Negatively Regulated by IL-22 via Activation
of NLRC4 and IL-1Ra Borghi
et al, 2015
IL3- interleukin 3: IL-3 up-modulates MR, Dectin-1, and DC-SIGN,
thus allowing more efficient fungal uptake/phagocytosis in macrophages
Cardone
et al, 2014.
IL4 interleukin 4 : Candida albicans induced IL4, CCL22, IFN-gamma
and IP10 secretion in peripheral blood mononuclear cells Kanda
et al, 2002
IL6 interleukin 6: Candida albicans PLM increased the mRNA expressions
and secretions of proinflammatory cytokines (IL6) and chemokines
(IL8) in THP-1 cells Chen
et al, 2011
IL10 interleukin 10: Fungal chitin dampens inflammation through
IL10 induction mediated by NOD2 and TLR9 activation Wagener
et al, 2014
IL12A IL12B Interleukin 12 (dimer) induced by Candida albicans
or Saccharomyces cerevisiae Biondo
et al, 2012
IL13 may play an important immunoregulatory role against C. albicans
Katsifa
et al, 2011.
IL15 genes encoding IL15, the IL13RA1, and CD14 were suppressed
during the 18-h exposure to C. albicans normal human monocytes Kim
et al, 2005
IL13RA1 interleukin 13 receptor subunit alpha 1: genes encoding
IL15, the IL13RA1, and CD14 were suppressed during the 18-h exposure
to C. albicans normal human monocytes Kim
et al, 2005
IL17A – interleukin 17A: induces artificial nutrient starvation
conditions in Candida albicans Zelante
et al, 2012 IL-17 pathway regulates antifungal immunity through
upregulation of proinflammatory cytokines, including IL6, and neutrophil-recruiting
chemokines (e.g., CXCL1 and CXCL5), and antimicrobial peptides Conti
and Gaffen, 2015
IL17RC interleukin 17 receptor C: required for in vivo IL-17-dependent
responses during oral mucosal infections caused by Candida albicans
Ho
et al, 2015
IL18 – interleukin 18 (interferon-gamma-inducing factor):
Sap2 and Sap6 fungal proteins trigger IL1B and IL18 production through
inflammasome activation, via NLRP3 and caspase-1 activation in monocyte-derived
macrophages and dendritic cells Pietrella
et al, 2013
IL22 interleukin 22 : IL-22 and IDO1 are crucial in balancing
resistance with tolerance to Candida infection De
Luca et al, 2015
IL33 interleukin 33: IL-33 Enhances Host Tolerance to Candida
albicans Kidney Infections through Induction of IL-13 Production
by CD4+ T Cells Tran
et al, 2015
IL34 interleukin 34 : Suppresses Candida albicans Induced TNFa
Production in M1 Macrophages by Downregulating Expression of Dectin-1
and TLR2 Xu
et al, 2015.
IL36RN interleukin 36 receptor antagonist: Reduces Candida-Induced
Th17 Responses van
de Veerdonk et al, 2012.
IL37 interleukin 37: interferes with the innate protective anti-Candida
host response by reducing the production of proinflammatory cytokines
and suppressing neutrophil recruitment in response to Candida van
de Veerdonk et al, 2015
IL1F10 interleukin 1 family member 10 (theta): (IL38) inhibits
Candida-induced Th17 cytokine production via IL1RL2 (interleukin
1 receptor-like 2) van
de Veerdonk et al, 2012.
INPP5D inositol polyphosphate-5-phosphatase D: endogenous INPP5D
relocated to live or heat-killed Candida albicans-containing phagosomes
in a Dectin-1-dependent manner in GM-CSF-derived bone marrow cells
Blanco-Menéndez
et al, 2015
IRAK1 interleukin 1 receptor associated kinase : C. albicans-induced
endothelial NF-B-dependent gene expression requires IRAK1 and MyD88
Müller
et al, 2007
IRAK4 interleukin 1 receptor associated kinase 4 : infection of
macrophages with C. albicans, A. flavus, or A. fumigatus abrogated
the expression of the TLR signaling adaptors, IRAK1, IRAK4 and MyD88
Trinath
et al, 2014.
IRF1 interferon regulatory factor 1 : mice lacking TLR7 or IRF1
were hypersusceptible to systemic C. albicans infection Biondo
et al, 2012
IRF5 interferon regulatory factor 5 : Dectin-1-induced IFN-ß
production , by C. Albicans, required the tyrosine kinase Syk and
the transcription factor IRF5 del
Fresno et al, 2013
ITGAM – integrin, alpha M (complement component 3 receptor
3 subunit): ITGAM/ITGB2 is the principal adhesion receptor on leukocytes
for Candida albicans Forsyth
et al, 1998
ITGB2 – integrin, beta 2 (complement component 3 receptor
3 and 4 subunit): ITGAM/ITGB2 is the principal adhesion receptor
on leukocytes for Candida albicans Forsyth
et al, 1998
ITGAX ITGAX integrin subunit alpha X : Secreted aspartic protease
2 of Candida albicans inactivates factor H and the macrophage factor
H-receptors CR3 (ITGAM/ITGB2 dimer ) and CR4 (ITGAX/ITGB2dimer )
Svoboda
et al, 2015.
KLKB1 kallikrein B1: high-molecular-mass kininogen (KNG1), F12
,and prekallikrein - adhere to candidal cells Seweryn
et al, 2015
KLRK1 killer cell lectin-like receptor subfamily K, member : Innate
immune receptors such as CD16, as well as the adhesion marker NCAM1
(CD56) or immunoreceptor tyrosine-based activating motif (ITAM)-bearing
receptors such as NCR1 (CD335) and KLRK1 (CD314) were down-regulated
on natural killer (NK) cells after interaction with C.Albicans Voight
et al, 2014.
KNG1 kininogen 1: high-molecular-mass kininogen (KNG1), F12 )
and prekallikrein (PPK) - adhere to candidal cells Seweryn
et al, 2015
lactosylceramide: Cryptococcus neoformans, Candida albicans, and
other fungi bind specifically to lactosylceramide Jimenez-Lucho
et al, 1990
LGALS3 – lectin, galactoside-binding, soluble, 3: induces
death of Candida species expressing specific beta-1,2-linked mannans
Cohatsu
et al, 2006.
LCN2 lipocalin 2: enhanced sensitivity of LCN2(-/-) mice to both
intracellular (Listeria monocytogenes) and extracellular (Candida
albicans and Staphylococcus aureus) pathogens Liu
et al, 2013
LTA lymphotoxin alpha: TNF and LTA are critical to the stimulation
of effector cells that leads to elimination of Candida from abscesses
Vonk
et al, 2002
LTF – lactotransferrin: fungicidal effect on Candida albicans
Nikawa
et al, 1993
MALT1 MALT1 paracaspase: Engagement of Dectin-1 by fungal ß-glucans
leads to subsequent association of the Syk tyrosine kinase inducing
the assembly of a scaffold consisting of CARD9, BCL10, and MALT1
Hara
and Saito, 2009
MAP1LC3A microtubule associated protein 1 light chain 3 alpha:
Dectin-1-dependent MAP1LC3A recruitment to phagosomes enhances fungicidal
activity in macrophages Tam
et al, 2014.
MAP2K1 mitogen-activated protein kinase kinase 1: activated by
C.Albicans Liu
et al, 2015
MAP3K7 mitogen-activated protein kinase kinase kinase 7: TRAF6
and MAP3K7 play essential roles in C-type lectin receptor signaling
in response to Candida albicans infection .Gorjestaniet
al, 2012.
MAPK1 mitogen-activated protein kinase 1: Induced by C.Albicans
in human polymorphonuclear neutrophils Zhong
et al, 2003
MAPK3 mitogen-activated protein kinase : Candida albicans induces
PTGS2 expression and prostaglandin E2 production in synovial fibroblasts
through an extracellular-regulated kinase 1/2 dependent pathway
Lee
et al, 2009.
MAPK8 mitogen-activated protein kinase 8 : activated by C.Albicans
Liu
et al, 2015
MARCO macrophage receptor with collagenous structure: MARCO participates
in the uptake of both zymosan and C. albicans by CpG-ODN-pretreated,
but not untreated macrophages in mice Józefowski
et al, 2012
MASP2 – mannan-binding lectin serine peptidase 2: complex
formation between recombinant collectin-11 and recombinant MASP-2
on Candida albicans leads to deposition of C4b Ma
et al, 2013
MBL2 mannose-binding lectin (protein C) 2, soluble: binds to C.Albicans
van
Asbeck et al, 2008
MDK – midkine (neurite growth-promoting factor 2): has fungicidal
activity against Candida albicans and Candida parapsilosis Nordin
et al, 2012
MMP2 matrix metallopeptidase 2: activated by C.Albicans in human
oral epithelial cells Claveau
et al, 2004.
MMP9 matrix metallopeptidase 9: activated by C.Albicans in human
oral epithelial cells Claveau
et al, 2004.
MPO myeloperoxidase: MPO knockout mice were primarily susceptible
to C. albicans infection Suzuki,
2002
MRC1 mannose receptor, C type 1 (CD206): Mediates C.Albicans entry
in human dendritic cells Donini
et al, 2007
MSR1 macrophage scavenger receptor 1 : involved in both the binding
and phagocytosis of S. cerevisiae and Candida albicans Wang
et al, 2010
MTA2 metastasis associated 1 family member 2 :MTA2, IL2 and IL4
increase upon stimulation with C. albicans in mouse bone marrow
derived dendritic cells Tierney
et al, 2012
MTOR mechanistic target of rapamycin (serine/threonine kinase):
Protection against epithelial damage during Candida albicans infection
is mediated by PI3K/Akt and MTOR signaling Moyes
et al, 2014.
MYD88 myeloid differentiation primary response 88: C. albicans-induced
endothelial NF-B-dependent gene expression requires IRAK1 and MyD88
Müller
et al, 2007
NCR1 N-acetyl-neuraminic acid: C. albicans is coated with sialic
acids. N-acetyl-neuraminic acids are alpha2,6- and alpha2,3-linked
Soares
et al, 2000
NCAM1 neural cell adhesion molecule 1 : Innate immune receptors
such as CD16, as well as the adhesion marker NCAM1 (CD56) or immunoreceptor
tyrosine-based activating motif (ITAM)-bearing receptors such as
NCR1 (CD335) and KLRK1 (CD314) were down-regulated on natural killer
(NK) cells after interaction with C.Albicans Voight
et al, 2014.
NCR1 natural cytotoxicity triggering receptor 1: Innate immune
receptors such as CD16, as well as the adhesion marker NCAM1 (CD56)
or immunoreceptor tyrosine-based activating motif (ITAM)-bearing
receptors such as NCR1 (CD335) and KLRK1 (CD314) were down-regulated
on natural killer (NK) cells after interaction with C.Albicans Voight
et al, 2014.
NFKB1 – nuclear factor of kappa light polypeptide gene enhancer
in B-cells 1: C. albicans activates NF-kappaB and AP-1 (FOS) in
OE21 cells Steubesand
et al, 2009
NFKBIA nuclear factor of kappa light polypeptide gene enhancer
in B-cells inhibitor, alpha: Involved in fungal activation of chemokine
expression in endothelial cells Müller
et al, 2007
NLRC4 NLR family, CARD domain containing 4: mucosal expression
of NLRP3 and NLRC4 is induced by Candida infection Tomalka
et al, 2011
NLRP3 – NLR family, pyrin domain containing 3: Sap2 and
Sap6 fungal proteins trigger IL1B and IL18 production through inflammasome
activation, via NLRP3 and caspase-1 activation in monocyte-derived
macrophages and dendritic cells Pietrella
et al, 2013
NLRP10 NLR family, pyrin domain containing 10 : essential for
protective antifungal adaptive immunity against Candida albicans
Joly
et al, 2012.
NOD2 nucleotide binding oligomerization domain containing : Fungal
chitin dampens inflammation through IL10 induction mediated by NOD2
and TLR9 activation Wagener
et al, 2014
NOA1 nitric oxide associated 1: Downregulated in macrophages by
C.Albicans Kitahara
et al, 2015
NOS2 nitric oxide synthase 2, inducible : macrophage NOS2 suppressed
by C.Albicans Schröppel
et al, 2001
NPY neuropeptide Y: PYY and NPY stimulate macrophage function,
including C.Albicans ingestion De
la Fuente et al, 1993
NR5A2 nuclear receptor subfamily 5 group A member 2: Mice with
NR5A2 -deficient macrophages are highly susceptible to gastrointestinal
and systemic Candida albicans infection
OCLN occludin: Levels of occludin, E-cadherin, and desmoglein-2
reduced by C.Albicans in human intestinal epithelial monolayers
Frank
and Hostetter, 2007.
Oestrogen: a fungal estrogen-binding protein binds mammalian estrogens
with high affinity Madani
et al, 1994
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1 Induced by C.Albicans
in human polymorphonuclear neutrophils Zhong
et al, 2003
PARP1 poly(ADP-ribose) polymerase 1: involved in C.albicans induced
apoptosis in oral epithelial cells Villar
et al, 2012
PDGFA platelet-derived growth factor alpha polypeptide, and PDGFB
: peptides derived from HBEGF, amphiregulin, hepatocyte growth factor,
PDGF-A and PDGF-B, as well as various FGFs are antimicrobial and
antifungal Malmsten
et al, 2007
PDIA3 protein disulfide isomerase family A member 3: Protein levels
decreased in infected mouse macrophages Martínez-Solano
et al, 2006
PGLYRP2 peptidoglycan recognition protein: suppresses colony-forming
units of Candida albicans in vitro. PGLYRP3 and PGLYRP4 induced
by C.Albicans in corneal epithelial cells Hua
et al, 2015
PENK proenkephalin: Met-enkephalin, Leu-enkephalin, and beta-endorphin
reduced the expression of vimentin filaments in human monocytes
and their phagocytic activity versus C.Albicans Prieto
et al, 1989,
PIAS1 protein inhibitor of activated STAT 1: infection of macrophages
with C. albicans, A. flavus, and A. fumigatus induced robust activation
of WNT5A signaling and increased expression of PIAS-1 and SOCS-1
Trinath
et al, 2014.
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic
subunit alpha: activated by C.Albicans Liu
et al, 2015
PLA2G4A phospholipase A2 group IVA: activated by C.Albicans in
alveolar macrophages Parti
et al, 2010
Polyamines: Host putrescine required for hyphae formation Herrero
et al, 1999 and the fungus possesses a spermidine uptake system
(DUR31) Meyer
et al, 2012
POMC – proopiomelanocortin: Precursor for multiple peptides
including alpha-MSH which has antifungal effects versus C.Albicans
Catania
et al, 2006
PPARG peroxisome proliferator-activated receptor gamma : pioglitazone-treated
mice were strongly protected against lethal Ca challengeMajer
et al, 2012.
PRKCA protein kinase C, alpha: involved in phagocytosis of complement-opsonized
Candida albicans Ma
et al, 2015
PRKCD protein kinase C, delta: Candida albicans-induced cytokine
production was blocked in Prkcd(-/-) cells, and Prkcd(-/-) mice
were highly susceptible to fungal infection Strasser
et al, 2012.
PSMB8 proteasome subunit beta 8: Inhibition of this immunoproteosome
component results in increased susceptibility to systemic candidiasis
Mundt
et al, 2016
PTAFR platelet-activating factor receptor: activation of the PAF
pathway is crucial for PUVA-induced immune suppression (as measured
by suppression of delayed type hypersensitivity to Candida albicans)
Wolf
et al, 2006
PTEN phosphatase and tensin homolog : PTEN directly activates
the actin depolymerization factor cofilin-1 during PGE2-mediated
inhibition of phagocytosis of fungi Serezani
et al , 2012.
PTGER2 prostaglandin E receptor 2: Prostaglandin E2 suppressed
fungal phagocytosis and F-actin formation through the PGE(2) receptors
PTGER2 and EP4 Serezani
et al , 2012
PTGER4 prostaglandin E receptor 4 : Prostaglandin E2 suppressed
fungal phagocytosis and F-actin formation through the PGE(2) receptors
PTGER2 and EP4 Serezani
et al , 2012
PTGIR prostaglandin I2 (prostacyclin) receptor (IP) : Expression
increased in C.Albicans treated macrophages Suram
et al, 2015
PTK2 protein tyrosine kinase 2: Activated by C.Albicans in keratinocytes
Shi
et al, 2009
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H
synthase and cyclooxygenase) : macrophages infected with Candida
albicans, Aspergillus flavus or Aspergillus fumigatus or treated
with Curdlan, a selective agonist of pattern recognition receptor
for fungi Dectin-1, displays increased expression of ALOX5, ALOX15
and PTGS2 Karnam
et al, 2015.
PTPN11 protein tyrosine phosphatase, non-receptor type 11: dendritic
cell-derived PTPN11 was crucial for the induction of interleukin
1ß (IL-1ß), IL-6 and IL-23 and anti-fungal responses
of the TH17 subset of helper T cells in controlling infection with
Candida albicans Deng
et al, 2015.
PTX3 pentraxin 3 : upregulated by C.Albicans in mouse bone marrow-derived
macrophages and bone marrow-derived dendritic cells Tierney
et al, 2012
PYY peptide YY: PYY and NPY stimulate macrophage function, including
C.Albicans ingestion De
la Fuente et al, 1993
RAB5A RAB5A, member RAS oncogene family: recruited to phagosomes
containing C. albicans Okai
et al, 2015
RAB7A, member RAS oncogene family: recruited to phagosomes containing
C. albicans Okai
et al, 2015
RAB14 RAB14, member RAS oncogene family: Phagosomes containing
live C. albicans cells became transiently Rab14 positive within
2 min following engulfment Okai
et al, 2015
RAB27A RAB27A, member RAS oncogene family: Serum-treated Candida
albicans triggers neutrophil extracellular trap formation in a reactive
oxygen species -dependent manner, and Rab27a-knockdown inhibits
this process Kawakami
et al, 2014
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small
GTP binding protein Rac1): Expression of dominant-negative Rac1
or Cdc42 eliminated C albicans- mediated ERK phosphorylation and
phagocytosis and granule migration toward the ingested microbes
Zhong
et al, 2003
RASGRF1 Ras protein specific guanine nucleotide releasing factor
1: CARD9 mediates Dectin-1-induced ERK activation by linking Ras-GRF1
to H-Ras for antifungal immunity
Jia et al, 2014.
RNASE7 ribonuclease, RNase A family, 7: defends against C.Albicans
independently of RNASE activity Swidergall
and , Ernst 2014
RORC RAR-related orphan receptor C: Impairment of immunity to
Candida and Mycobacterium in humans with bi-allelic RORC mutations
Okada
et al, 2015
RPL7L1 : interacts with C.Albicans in macrophages (as do NOA1
HSPA1A C3 and LUM) Kitahara
et al, 2015
RUBCN RUN domain and cysteine-rich domain containing, Beclin 1-interacting
protein: Has a Negative Effect on Host Antifungal Activity Yang
et al, 2012
S100A8 S100 calcium binding protein A8 Calprotectin (S100A8/S100A9
dimer) has antifungal activity Cederlund
et al, 2010
S100A12 S100 calcium binding protein A12: has antifungal activity
against Candida albicans, C. krusei, C. glabrata and C. tropicalis
Cunden
et al, 2016
SCAF11 SR-related CTD-associated factor 1 (caspase 11): caspase-1
and caspase-11 connect the canonical and noncanonical pathways of
inflammasome activation in response to C. albicans S-aspartyl proteases
Gabrielli
et al, 2015.
SCARF1 – scavenger receptor class F, member 1: SCARF1 and
CD36, mediate host defense against Cryptococcus neoformans and Candida
albicans Means
et al, 2009
SELPLG selectin P ligand: epithelial expression stimulated by
C.Albicans Schaller
et al, 2002
SEPT7 septin 7: accumulates with N-cadherin and actin microfilaments
around C. albicans as it was endocytosed by endothelial cells Phan
et al, 2013
Serotonin: 5-HT treatment of C. albicans significantly affected
hyphal extension suggesting an antifungal effect Mayr
et al, 2005
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase,
antitrypsin), member 1: cleaved by a fungal secreted aspartyl proteinase
Gogol
et al, 2015
SFTPD surfactant protein D: inhibited phagocytosis of C. albicans
by alveolar macrophages van
Rozendaal et al, 2000
SIGIRR single immunoglobulin and toll-interleukin 1 receptor (TIR)
domain: Inflammatory pathology and susceptibility to infection were
higher in SIGIRR (-/-) mice Bozza
et al, 2008
SIGLEC7 sialic acid binding Ig-like lectin 7: Binds to C.Albicans
Varchetta
et al, 2012
SLC11A1 solute carrier family 11 (proton-coupled divalent metal
ion transporter), member 1 (nramp1): recruited from tertiary granules
to the phagosomal membrane on phagocytosis of C.Albicans Canonne-Hergaux
et al, 2002
SLPI secretory leukocyte peptidase inhibitor: has fungicidal activity
toward metabolically active A. fumigatus conidia and C. albicans
yeast cells Tomee
et al, 1997;
SOCS1 suppressor of cytokine signaling 1: enhances the maturation
and antifungal immunity of dendritic cells in response to Candida
albicans Shi
et al, 2015
SOCS3 suppressor of cytokine signaling 3 : regulated in human
monocytes exposed to C.Albicans: up-regulated at 4 to 6 h and remained
elevated throughout the 18-h time courseKim
et al, 2005
Sphingolipids: Candida albicans was susceptible to sphinganine,
sphingosine, dimethylsphingosine, and to a lesser degree, stearylamine
Bibel
et al, 1993 and to phytosphingosine Veerman
et al, 2010
SPP1 secreted phosphoprotein 1: The prophylactic provision of
micafungin prior to Candida albicans infection was characterized
by an increase in the proinflammatory cytokines CXCL13 and SPP1
Fuchs
et al, 2016
SPTLC2 serine palmitoyltransferase, long chain base subunit 2:
Sptlc2-/- DC2.4 cells exhibited a stark defect in phagocytosis,
were unable to bind fungal particles and failed to form a normal
phagocytic cup to engulf C. albicans .
SQSTM1 involved in the autophagy and chemokine response to C.Albicans
(=p62 in this paper) Kanayama
et al, 2015
STATH statherin salivary protein that induces transition of hyphae
to yeast Leito
et al, 2009
STX4 syntaxin 4: VAMP3, ADAM17 and STX4 incolved in the movement
of TNF to the phagosomal cup during C.Albicans phagocytosis Murray
et al, 2005
SYK spleen tyrosine kinase : ß-glucans and Candida albicans
induced Syk phosphorylation, and Syk inhibition significantly decreased
ß-glucan-induced chemokine secretion from Intestinal epithelial
cells Cohen-Kedar
et al, 2014.
TAC1 tachykinin precursor 1: Substance P has antifungal properties
Kowalska
et al, 2002
TFPI antimicrobial against the gram-negative bacteria Escherichia
coli and Pseudomonas aeruginosa, gram-positive Bacillus subtilis
and Staphylococcus aureus, as well as the fungi Candida albicans
and Candida parapsilosis Papareddy
et al, 2010
TFRC transferrin receptor : regulated in human monocytes exposed
to C.Albicans: up-regulated at 4 to 6 h and remained elevated throughout
the 18-h time courseKim
et al, 2005
TGFB1 transforming growth factor beta 1: hepcidin induction by
heat-killed Candida albicans hyphae was IL-6-independent, but partially
TGF-ß-dependent Armitage
et al, 2011
THBS1 thrombospondin 1: enhances the early innate immune response
against C. albicans and promotes activation of inflammatory macrophages
(NOS1, IL6, TNF-a, IL10), release of the chemokines MIP-2, CCL2
MIP-1a, and RANTES, and CXCR2-driven polymorphonuclear leukocytes
recruitment Martin-Manso
et al, 2012
TICAM1 toll-like receptor adaptor molecule 1: Functional yet balanced
reactivity to Candida albicans requires TICAM1, MyD88, and IDO-dependent
inhibition of RORC De
Luca et al, 2007.
TIMP1 TIMP metallopeptidase inhibitor 1: Cell fractions of Candida
albicans, C. parapsilosis Cp2, Candida glabrata reference strain,
and Candida krusei fragmented TIMP1 (28 kDa) to a 24-kDa species
Pärnänen
et al, 2011
TLR2 toll-like receptor 2 :TLR2 and TLR4, acting via the adapter
protein MyD88, signal responses to Cryptococcus neoformans, Aspergillus
fumigatus and Candida albicans in vitro Levitz,
2004
TLR3 C. albicans-induced CXCL8/IL-8 expression in endothelial
cells is mediated by TLR3 rather than TLR2 and TLR4 Müller
et al, 2007
TLR4 toll-like receptor 4 : TLR2 and TLR4, acting via the adapter
protein MyD88, signal responses to Cryptococcus neoformans, Aspergillus
fumigatus and Candida albicans in vitro Levitz,
2004
TLR6 toll-like receptor 6 : recognition of C. albicans by TLR6
modulated the balance between Th1 and Th2 cytokines Netea
et al, 2008
TLR7 toll-like receptor 7: partially required for the induction
of IL12A/IL12B by Candida albicans or Saccharomyces cerevisiae Biondo
et al, 2012
TLR9 Toll-like receptor 9: TLR9 recruitment to the macrophage
phagosomal membrane is a conserved feature of fungi of distinct
phylogenetic origins, including Candida albicans, Saccharomyces
cerevisiae, Malassezia furfur, and Cryptococcus neoformans Kasperkovitz
et al, 2011 .
TRAF6 TNF receptor associated factor 6: TRAF6 and MAP3K7 play
essential roles in C-type lectin receptor signaling in response
to Candida albicans infection .Gorjestaniet
al, 2012.
UBASH3A ubiquitin associated and SH3 domain containing A: Functional
inactivation leads to profound resistance to systemic infection
by C. albicans Naseem
et al, 2015
UBASH3B ubiquitin associated and SH3 domain containing B: Functional
inactivation leads to profound resistance to systemic infection
by C. albicans Naseem
et al, 2015
VAMP3 vesicle associated membrane protein 3: VAMP3, ADAM17 (Tace)
and STX4 incolved in the movement of TNF to the phagosomal cup during
C.Albicans phagocytosis Murray
et al, 2005
VAV1 vav guanine nucleotide exchange factor 1: BTK and Vav1 contribute
to Dectin1-dependent phagocytosis of Candida albicans in macrophages
Strijbis
et al, 2013
VAV3 vav guanine nucleotide exchange factor 3: Vav1,3-deficient
mice have increased susceptibility to systemic candidiasis Li
et al, 2011
VIP vasoactive intestinal polypeptide : stimulates macrophage
function, including C.Albicans ingestion De
la Fuente et al, 1993
VSIG4 V-set and immunoglobulin domain containing 4: involved in
phagocytosis of complement-opsonized Candida albicans Ma
et al, 2015
WASL Wiskott-Aldrich syndrome-like: Involved in fungal endocytosis
in human endothelial cells Shintaku
et al, 2013
WNT5A wingless-type MMTV integration site family member 5A : infection
of macrophages with C. albicans, A. flavus, and A. fumigatus induced
robust activation of WNT5A signaling and increased expression of
PIAS-1 and SOCS-1 and GSK3B phosphorylation Trinath
et al, 2014.
XIAP X-linked inhibitor of apoptosis: Xiap(-/-) mice became highly
vulnerable toCandida albicans infection Hsieh
et al, 2014.
Candida albicans induces pro-inflammatory and anti-apoptotic
signals in macrophages as revealed by quantitative proteomics and
phosphoproteomics Reales-Calderón
et al, 2013
Sub-proteomic study on macrophage response to Candida albicans
unravels new proteins involved in the host defense against the fungus
Reales-Calderón
et al, 2012
Proteomics of RAW 264.7 macrophages upon interaction with
heat-inactivated Candida albicans cells unravel an anti-inflammatory
response Reales-Calderón
et al, 2009
Candida albicans Triggers Activation of Distinct Signaling
Pathways to Establish a Proinflammatory Gene Expression Program in
Primary Human Endothelial Cells Müller
et al, 2007
The Fungal Quorum-Sensing Molecule Farnesol Activates Innate
Immune Cells but Suppresses Cellular Adaptive Immunity Leonhardt
et al, 2015(Farnesol is a quorum-sensing molecule produced
by C.Albicans)
Effects of farnesol on gene expression in dendritic cells