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Host proteins used by Candida Albicans during its life cycle.

If you know of other direct interactions, (or corrections) please with Pubmed ID, gene symbol/accession number and viral interacting protein. Thank you.

 

  1. ADAM17 ADAM metallopeptidase domain 17 (Tace) : VAMP3, ADAM17 and STX4 incolved in the movement of TNF to the phagosomal cup during C.Albicans phagocytosis Murray et al, 2005
  2. AKT1 v-akt murine thymoma viral oncogene homolog 1 : Fungal secreted aspartyl proteases induced Akt activation and phosphorylation of IKBa, which mediates translocation of NFKB1 into the nucleus in monocytes Pietrella et al, 2010.
  3. ALOX5 arachidonate 5-lipoxygenase: macrophages infected with Candida albicans, Aspergillus flavus or Aspergillus fumigatus or treated with Curdlan, a selective agonist of pattern recognition receptor for fungi Dectin-1, displays increased expression of ALOX5, ALOX15 and PTGS2 Karnam et al, 2015.
  4. ALOX15 arachidonate 15-lipoxygenase : see Karnam et al, 2015.
  5. ANXA1 Annexin 1: Protein levels increased in infected mouse macrophages Martínez-Solano et al, 2006
  6. APOBEC3F apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F: Candida albicans enhanced the production of the CCR5-interacting chemokines CCL3, CCL4, and CCL5, and stimulates the production of interferon-a and the restriction factors APOBEC3G, APOBEC3F, and tetherin (BST2) in macrophages Rodriguez et al, 2013.
  7. APOE – apolipoprotein E: C.albicans growth enhanced in ApoE -/- plasma: depletion of lipoproteins from plasma resulted in a significant seven- to tenfold increase in C. albicans growth Vonk et al, 2004
  8. APOH apolipoprotein H: reduces Kupffer cell Candida albicans phagocytosis index and killing score Gomes et al 2002
  9. APP amyloid precursor protein: beta-amyloid is an antimicrobial peptide with activity against C.Albicans Socsia et al, 2010
  10. Arachidonic acid: During infection, arachidonic acid is released from host phospholipids, leading to the production of host and yeast derived prostaglandin E(2) . This stimulates yeast hyphal formation, is immunomodulatory and causes cell damage during infection Ells et al, 2012.
  11. AREG amphiregulin: peptides derived from HBEGF, amphiregulin, hepatocyte growth factor, PDGF-A and PDGF-B, as well as various FGFs are antimicrobial and antifungal Malmsten et al, 2007
  12. ARHGDIB Rho GDP dissociation inhibitor (GDI) beta: Protein levels increased in infected mouse macrophages Martínez-Solano et al, 2006
  13. ATG5 autophagy related 5: Disruption of host autophagy in vitro by RNA interference against ATG5 decreased the phagocytosis of C. albicans Nicola et al, 2012
  14. ATG7 autophagy related 7 : Lack of ATG7 attenuates host resistance against Candida Kanayama et al, 2015
  15. BCL10 B-cell CLL/lymphoma 10: hyphae stimulation induces CARD9 association with Bcl10, an adaptor protein that functions downstream of CARD9 and is also involved in C. albicans-induced NF-kappaB activation Bi et al, 2010
  16. BDKRB1 bradykinin receptor B1: Kininogen degrading secreted aspartyl proteases from C.Albicans produve bradykinins capable of stimulating BDKRB1 and -2 Rapala-Kozik et al, 2010
  17. BDKRB2 bradykinin receptor B2: Rapala-Kozik et al, 2010
  18. BST2 bone marrow stromal cell antigen 2 (Tetherin): Candida albicans enhanced the production of the CCR5-interacting chemokines CCL3, CCL4, and CCL5, and stimulates the production of interferon-a and the restriction factors APOBEC3G, APOBEC3F, and tetherin (BST2) in macrophages Rodriguez et al, 2013.
  19. BTK Bruton agammaglobulinemia tyrosine kinase: BTK and Vav1 contribute to Dectin1-dependent phagocytosis of Candida albicans in macrophages Strijbis et al, 2013
  20. C3 – complement component 3: Fungal Pra1 binds to fluid-phase C3 and blocks cleavage of C3 to C3a and C3b Luo et al, 2010
  21. C4BPA – complement component 4 binding protein, alpha: Binds to C.Albicans Pra 1 Luo et al, 2011
  22. C5 complement component 5: C5a is a critical mediator in human blood during C. albicans infection.Hünniger et al, 2014
  23. CALCA calcitonin-related polypeptide alpha: Procalcitonin decreased both phagocytic and candidacidal activity of polymorphonuclear leukocytes Pincíková et al, 2005
  24. CAMP cathelicidin antimicrobial peptide: defends against C.Albicans Swidergall and , Ernst 2014
  25. CARD9 caspase recruitment domain family member: mediates Dectin-1-induced ERK activation by linking Ras-GRF1 to H-Ras for antifungal immunity Jia et al, 2014.
  26. CASP1 – caspase 1, apoptosis-related cysteine peptidase: Sap2 and Sap6 fungal proteins trigger IL1B and IL18 production through inflammasome activation, via NLRP3 and caspase-1 activation in monocyte-derived macrophages and dendritic cells Pietrella et al, 2013
  27. CASP3 caspase 3: CASP3 and CASP9 involved in C.albicans induced apoptosis in oral epithelial cells Villar et al, 2012
  28. CASP8 caspase 8, apoptosis-related cysteine peptidase : A strong requirement for CR3 and caspase-8 also was found for NLRP3-dependent IL-1ß production in response to heat-killed C. albicans Ganesan et al, 2008.
  29. CASP9 caspase 9: CASP3 and CASP9 involved in C.albicans induced apoptosis in oral epithelial cells Villar et al, 2012
  30. CCL3, CCL4,TNF, IL8 and CD83 upregulated by C.Albicans in monocytes: RGS1, RGS2, RGS16, DSCR1, CXCL2, EGR3, FLT4, and TNFAIP6 were also up-regulated in response to C. albicans, whereas CCR2 and NCF2 were among the genes down-regulated Barker et al, 2005
  31. CCL5 chemokine (C-C motif) ligand 5 : Candida albicans enhanced the production of the CCR5-interacting chemokines CCL3, CCL4, and CCL5, and stimulates the production of interferon-a and the restriction factors APOBEC3G, APOBEC3F, and tetherin (BST2) in macrophages Rodriguez et al, 2013.
  32. CCL18 chemokine (C-C motif) ligand 18 : selectively down-regulated in dendritic cells during the maturation process induced by LPS, TNF, CD40 ligand, Staphylococcus aureus Cowan I, Candida albicans, and influenza virus.
  33. CCL20 has antimicrobial effects on Escherichia coli, Pseudomonas aeruginosa, Moraxella catarrhalis, Streptococcus pyogenes, Enterococcus faecium, Staphylococcus aureus, and Candida albicans: CXCl2/growth-related ß (Groß), CXCL10/IP-10, CXCL11/I-TAC, CXCL12/SDF-1a, CCL11/eotaxin, and CCL13/MCP-4 also demonstrated low anti-C. albicans activityYang et al, 2003.
  34. CCL21 epithelial expression stimulated by C.Albicans Schaller et al, 2002
  35. CCL28 chemokine (C-C motif) ligand 28 : CCL28 has potent antimicrobial activity against Candida albicans, Gram-negative bacteria, and Gram-positive bacteria Hieshima et al, 2003.
  36. CCR1, CCR5, CCR7, and CXCR5 chemokine receptor upregulated in human monocytes exposed to C.Albicans: IL15, IL13RA1, and CD14 were suppressed during the 18-h exposure to C. albicansKim et al, 2005
  37. CD5 – CD5 molecule: the CD5 ectodomain binds to and aggregates fungal cells (Schizosaccharomyces pombe, Candida albicans, and Cryptococcus neoformans) but not to Gram-negative (Escherichia coli) or Gram-positive (Staphylococcus aureus) bacteria Vera et al, 2009.
  38. CD28:mice are incapable of resistance to reinfection. in CD86 or CD28-deficient mice Montagnoli et al, 2002
  39. CD33 My9, a monoclonal antibody to CD33 binds to C.Albicans (antigen mimicry) Mayer et al, 1990
  40. CD36 – CD36 molecule (thrombospondin receptor): SCARF1 and CD36, mediate host defense against Cryptococcus neoformans and Candida albicans Means et al, 2009
  41. CD37 CD37-/- mice are better protected from fungal infection van Spriel et al, 2009
  42. CD40 CD40 molecule, TNF receptor superfamily member 5 : absence of CD40/CD40LG interactions results in increased susceptibility to disseminated infection with C. albicans through decreased NO-dependent killing of Candida by macrophages Netea et al, 2002.
  43. CD40LG CD40 ligand Netea et al, 2002.
  44. CD47: cd47-/- mice on a C57BL/6 background showed significantly increased morbidity and mortality following Candida albicans infection Navarathna et al, 2015
  45. CD69 up-regulation splenic B and T cells of C57Bl/6 mice after administration of lipopolysaccharide or microbial immunosuppressive/mitogenic proteins produced by C. albicans Vilanova et al, 1996
  46. CD80 Dendritic cells stimulated by C. albicans and A. fumigatus induced DC maturation by increasing CD80 and CD86 co-stimulatory molecules Fidan et al, 2014
  47. CD82 actively recruited to phagosomes containing Candida albicans Artavanis-Tsakonas et al, 2011
  48. CD83 upregulated in THP-1 cells in response to C.Albicans Barker et al, 2005
  49. CD86: mice are incapable of resistance to reinfection. in CD86 or CD28-deficient mice Montagnoli et al, 2002 Farnesol (secreted by C.Albicans) enhanced the expression of activation markers on monocytes (CD86 and HLA-DR) and neutrophils (CEACAM8 and ITGAM): CD1a, CD83, CD86, and CD80 were significantly reduced Leonhardt et al, 2015
  50. CD207 (langerin) binds to a variety of Candida and Saccharomyces species and weakly to cryptocci De Jong et al, 2010
  51. CD209 (DC-SIGN): C.Albicans is a ligand Bloem et al, 2014
  52. CDC42 cell division cycle 42: Expression of dominant-negative Rac1 or Cdc42 eliminated C albicans- mediated ERK phosphorylation and phagocytosis and granule migration toward the ingested microbes Zhong et al, 2003
  53. CDH1 – cadherin 1, type 1, E-cadherin (epithelial): Fungal Als3 required for C. albicans to bind to multiple host cell surface proteins, including N-cadherin on endothelial cells and E-cadherin on oral epithelial cells Phan et al, 2007.
  54. CDH2 – cadherin 2, type 1, N-cadherin (neuronal): mediates endocytosis of Candida albicans by endothelial cells Phan et al, 2005
  55. CEBPB CCAAT/enhancer binding protein (C/EBP), beta: defective production of bioactive IL12 and the impaired Th1 responses of C/EBPbeta-deficient mice to Candida albicans infection Gorgoni et al, 2002
  56. CERS3 ceramide synthase 3: Mutant skin in CRES3 knockout mice is prone to Candida albicans infection Jennemann et al, 2012
  57. CFH – complement factor H: Binds to C.Albicans Meri et al, 2013
  58. CFHR1 complement factor H-related 1: Binds to C.Albicans Meri et al, 2013
  59. CFL1 cofilin 1 (non-muscle) : PTEN directly activates the actin depolymerization factor cofilin-1 during PGE2-mediated inhibition of phagocytosis of fungi Serezani et al , 2012.
  60. CHGA chromogranin A: Peptide derivatives have antifungal activity (See Refseq)
  61. CHI3L1 chitinase 3 like 1: Promotes C.Albicans killing Gao and Yu, 2015
  62. CLEC4D C-type lectin domain family 4 member D (Dectin 3): Dectin-3 and Dectin-2 form a heterodimeric pattern-recognition receptor for host defense against fungal infection Zhu et al, 2013
  63. CLEC4E C-type lectin domain family 4 member E: essential component of the innate immune response to Candida albicans Wells et al, 2008
  64. CLEC6A C-type lectin domain family 6 member A (Dectin 2) : pattern recognition receptor for fungi that couples with the Fc receptor gamma chain to induce innate immune responses Sato et al, 2006.
  65. CLEC7A – C-type lectin domain family 7, member A (Dectin 1) : binds fungal glucans and induces innate immune responses to fungal pathogens Adams et al, 2008.
  66. CLTA clathrin, light chain A : host E-cadherin, clathrin, dynamin and cortactin accumulate at sites of C. albicans internalization Moreno-Ruiz et al, 2009
  67. CLTC clathrin, heavy chain (Hc): Moreno-Ruiz et al, 2009
  68. COLEC11 – collectin sub-family member 11: complex formation between recombinant collectin-11 and recombinant MASP-2 on Candida albicans leads to deposition of C4b Ma et al, 2013
  69. Copper: C.Albicans has a copper uptake system and host copper levels modify its ability to deal with superoxide radicals Li et al,2015
  70. CRP C-reactive protein, pentraxin-related: associated with fungal biofilms Nett et al, 2015
  71. CSF2 colony stimulating factor 2 (granulocyte-macrophage): epithelial expression stimulated by C.Albicans Schaller et al, 2002
  72. CSF3 colony stimulating factor 3: 3 days after Candida infection increased numbers of granulocyte-macrophage and macrophage progenitors were observed in the bone marrow of CSF3-deficient mice Basu et al, 2000
  73. CSF1R colony stimulating factor 1 receptor : Downregulated during monocytes to iDC differentiation by farnesol ( a compound secreted by C.Albicans) Leonhardt et al, 2015
  74. CSTA cystatin A: Cleaved by Candida aspartic proteinase Tsushima et al, 1994
  75. CTLA4 cytotoxic T-lymphocyte-associated protein : IDO activity was induced at sites of infection as well as in dendritic cells and effector neutrophils via IFNG and CTLA4-dependent mechanisms Bozza et al, 2005.
  76. CTTN cortactin: host E-cadherin, clathrin, dynamin and cortactin accumulate at sites of C. albicans internalization Moreno-Ruiz et al, 2009
  77. CTSD cathepsin D: Phagosomal traffic controlled by C.Albicans Fernández-Arenas et al, 2009
  78. CXCL13 chemokine (C-X-C motif) ligand 13 : The prophylactic provision of micafungin prior to Candida albicans infection was characterized by an increase in the proinflammatory cytokines CXCL13 and SPP1 Fuchs et al, 2016
  79. CX3CR1 chemokine (C-X3-C motif) receptor 1(Fractalkine receptor): CX3CR1-dependent renal macrophage survival promotes Candida control and host survival Lionakis et al, 2013.
  80. CXCL10 (IP10): Candida albicans induced IL4, CCL22, IFN-gamma and IP10 secretion in peripheral blood mononuclear cells Kanda et al, 2002
  81. CXCL14 chemokine (C-X-C motif) ligand 14 : Antifungal chemokine Maerki et al, 2009
  82. CXCR3 chemokine (C-X-C motif) receptor 3: CXCR3-expressing natural killer cells contribute to fungal eradication in mouse corneas Romagnoli et al, 2004.
  83. CXCR4 chemokine (C-X-C motif) receptor 4 : increased CCR7/CXCR4 and decreased CCR5 expression in C.albicans infected dendritic cells Romagnoli et al, 2004.
  84. CYCS cytochrome c, somatic: involved, with CASP3 and CASP9 in C.albicans induced apoptosis in oral epithelial cells Villar et al, 2012
  85. DCD dermcidin antifungal peptide Cipáková et al, 2006
  86. DEFA1 defensin alpha 1: defends against C.Albicans Swidergall and , Ernst 2014
  87. DEFA5 defensin alpha 5 antifungal peptide Porter et al, 1997
  88. DEFB1 DEFB2 DEFB3 defensin beta 1,2,3 defend against C.Albicans Swidergall and , Ernst 2014
  89. DEFB4A – defensin, beta 4A: C. albicans induces upregulation of DEFB4A and DEFB103B in polymorphonuclear leukocytes Steubesand et al, 2009
  90. DEFB103B – defensin, beta 103B: C. albicans induces upregulation of DEFB4A and DEFB103B in polymorphonuclear leukocytes Steubesand et al, 2009
  91. DEFB114 defensin beta 114: antimicrobial against C.Albicans Yu et al, 2013
  92. DMBT1 – deleted in malignant brain tumors 1: inhibits Candida albicans-induced complement activation Reichhardt et al, 2012
  93. DNM2 dynamin 2: host E-cadherin, clathrin, dynamin and cortactin accumulate at sites of C. albicans internalization Moreno-Ruiz et al, 2009
  94. DSG2 desmoglein 2 Levels of occludin, E-cadherin, and desmoglein-2 reduced by C.Albicans in human intestinal epithelial monolayers Frank and Hostetter, 2007
  95. EEA1 – early endosome antigen 1L : C. albicans-containing endosomes transiently acquir early endosomal marker EEA1 Zhao and Villar, 2011
  96. EDN1 endothelin 1: Cleaved by a fungal aspartyl protease Tsushima and Mine, 1995
  97. EGFR – epidermal growth factor receptor: EGFR and ERBB2 signaling mediate epithelial cell invasion by Candida albicans during oropharyngeal infection Zhu et al, 2012.
  98. EIF3F eukaryotic translation initiation factor 3 subunit F: Protein levels decreased in infected mouse macrophages Martínez-Solano et al, 2006
  99. ERBB2 – v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian): EGFR and ERBB2 signaling mediate epithelial cell invasion by Candida albicans during oropharyngeal infection Zhu et al, 2012.
  100. F2 coagulation factor II (thrombin): activated by Candida proteinases Kaminishi et al, 1994
  101. F2R coagulation factor II (thrombin) receptor: Inflammation was promoted by F2R and F2RL1 activation in response to Candida Moretti et al, 2008
  102. F2RL1 coagulation factor II (thrombin) receptor-like 1 : Inflammation was promoted by F2R and F2RL1 activation in response to Candida Moretti et al, 2008
  103. F10 coagulation factor X: converted to the active form (Xa) by both Candida and Pseudomonas proteinases Kaminishi et al, 1994
  104. F12 coagulation factor XII (Hageman factor): high-molecular-mass kininogen (KNG1), F12 ) and prekallikrein (PPK) - adhere to candidal cells Seweryn et al, 2015
  105. FAS Fas-FasLG interactions are involved in host defense against lethal infection with Candida albicans Netea et al, 1999
  106. FASLG Fas ligand (TNF superfamily, member 6): Candida albicans up-regulates the Fas-L expression in liver Natural Killer and Natural Killer T cells Renna et al, 2015.
  107. FCAR antibodies directed to either FcgammaRI (CD64) or FCAR (CD89) on human PMNL effectively enhanced both phagocytosis and killing of C. albicans in vitro van Spriel et al 1999
  108. FCER1G Fc receptor, IgE, high affinity I, gamma polypeptide : CLEC6A pattern recognition receptor for fungi couples with the Fc receptor gamma chain to induce innate immune responses Sato et al, 2006.
  109. FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64): FcgammaRI initiates potent anti-C. albicans immunity van Spriel et al, 2001
  110. FCGR3A Fc fragment of IgG, low affinity IIIa, receptor (CD16a) and FCGR3B: Innate immune receptors such as CD16, as well as the adhesion marker NCAM1 (CD56) or immunoreceptor tyrosine-based activating motif (ITAM)-bearing receptors such as NCR1 (CD335) and KLRK1 (CD314) were down-regulated on natural killer (NK) cells after interaction with C.Albicans Voight et al, 2014.
  111. FHL1 four and a half LIM domains 1: Binds to C. albicans Gpm1p Poltermann et al, 2007
  112. FN1 – fibronectin 1: binds to a fungal adhesin Penn and Klotz, 1994
  113. gamma secretase to do
  114. FOS – FBJ murine osteosarcoma viral oncogene homolog : C. albicans activates NF-kappaB and AP-1 (FOS)in OE21 cells Steubesand et al, 2009
  115. FUT7 fucosyltransferase 7 (alpha (1,3) fucosyltransferase): the phagocytic activity in FUT7 -/- mice was significantly reduced Bartunková et al, 2000.
  116. GAL galanin/GMAP prepropeptide: GMAP has growth-inhibiting activity against C. albicans and inhibits the budded-to-hyphal-form transition Rauch et al, 2007
  117. GAPDH glyceraldehyde-3-phosphate dehydrogenase :a peptide derived from human GAPDH has antimicrobial activity Swidergall and , Ernst 2014
  118. GAST Gastrin: stimulates neutrophil function, including C.Albicans ingestion De la Fuente et al, 1993
  119. GCG – glucagon: stimulates hyphal formation Zelada et al, 1996
  120. Glucose: Fungal dependence on host glucose Ene et al, 2012
  121. Glutathione: Candida albicans lacks the ability to survive within its mammalian host in the absence of endogenous glutathione biosynthesis Desai et al, 2011
  122. GSK3B glycogen synthase kinase 3 beta : infection of macrophages with C. albicans, A. flavus, and A. fumigatus induced robust activation of WNT5A signaling and increased expression of PIAS-1 and SOCS-1 and GSK3B phosphorylation Trinath et al, 2014.
  123. GUSB glucuronidase, beta :Released by macrophages, with MPO, in response to C.Albicans Maródi et al, 1991
  124. Haemin and hemoglobin (HBA1 HBA2 HBB HBD HBE1 HBG1 HBG2) are used by C.Albicans to scavenge host iron Weissman et al, 2008 Haptoglobin (HP) or myoglobin (MB) may also be used Han, 2005
  125. HAMP hepcidin antimicrobial peptide: induced by heat-killed Candida albicans Armitage et al, 2011
  126. HBEGF heparin-binding EGF-like growth factor: peptides derived from HBEGF, amphiregulin, hepatocyte growth factor, PDGF-A and PDGF-B, as well as various FGFs are antimicrobial and antifungal Malmsten et al, 2007
  127. HGF hepatocyte growth factor (hepapoietin A; scatter factor): peptides derived from HBEGF, amphiregulin, hepatocyte growth factor, PDGF-A and PDGF-B, as well as various FGFs are antimicrobial and antifungal Malmsten et al, 2007
  128. HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor): pharmacologic activation of colonic Hif1a induces LL-37 expression and results in a significant reduction of C. albicans GI colonization in mice Fan et al, 2015
  129. HLA-DRB1 T cell epitopes of Candida albicans secretory aspartyl proteinase 2 bind to HLA-DRB1 Tongchusak et al, 2008
  130. HMOX1 heme oxygenase 1: cell wall beta-glucan from C. albicans stimulates pulmonary HMOX1 Inoue et al, 2009
  131. HRAS Harvey rat sarcoma viral oncogene homolog: CARD9 mediates Dectin-1-induced ERK activation by linking Ras-GRF1 to H-Ras for antifungal immunity Jia et al, 2014.
  132. HSPA1A heat shock protein family A (Hsp70) member 1A : Downregulated in macrophages by C.Albicans Kitahara et al, 2015
  133. HSPA5 heat shock protein family A (Hsp70) member 5 : Protein levels increased in infected mouse macrophages Martínez-Solano et al, 2006
  134. HSPA8 heat shock protein family A (Hsp70) member 8 : Protein levels decreased in infected mouse macrophages Martínez-Solano et al, 2006
  135. HSPA9 heat shock protein family A (Hsp70) member 9: Protein levels decreased in infected mouse macrophages Martínez-Solano et al, 2006
  136. HSPD1 heat shock protein family D (Hsp60) member 1: Protein levels decreased in infected mouse macrophages Martínez-Solano et al, 2006
  137. HSP90B1 – heat shock protein 90kDa beta (Grp94), member 1: The fungal invasin Als3 binds to HSP90B1,expressed on the surface of brain endothelial cells Liu et al, 2011
  138. HTN1 histatin 1: candidacidal peptide Driscoll et al, 1995
  139. HTN3 – histatin 3: Salivary protein that binds to C. albicans spheroplasts Xu et al, 1999
  140. HVCN1 hydrogen voltage gated channel 1: HVCN1 deficient mice exhibited more severe lung inflammation after intranasal Candida albicans infection than WT mice Okochi et al, 2015
  141. IDO1 indoleamine 2,3-dioxygenase 1 : IL-22 and IDO1 are crucial in balancing resistance with tolerance to Candida infection De Luca et al, 2015
  142. IFIH1 interferon induced, with helicase C domain 1: involved in the host defense against Candida infections Jaeger et al, 2015.
  143. IFNAR1 interferon (alpha, beta and omega) receptor 1 : C.Albicans invasiveness is protected in IFNAR1 knockout mice Majer et al, 2012.
  144. IFNB1 interferon, beta 1, fibroblast: Dectin-1-induced IFN-ß production , by C. Albicans, required the tyrosine kinase Syk and the transcription factor IRF5 del Fresno et al, 2013
  145. IFNG interferon, gamma: Candida albicans induced IL4, CCL22, IFN-gamma and IP10 secretion in peripheral blood mononuclear cells Kanda et al, 2002
  146. IGF1 insulin like growth factor 1: IGFI augmented the Polymorphonuclear neutrophilic leukocyte phagocytosis of both immunoglobulin G-opsonized Staphylococcus aureus and complement-opsonized Candida albicans Bjerknes and Aarskog, 1995
  147. IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta: Involved in fungal activation of chemokine expression in endothelial cells Müller et al, 2007
  148. IL1A interleukin 1 alpha: IL1A and IL1B are crucial for host defense against disseminated candidiasis Vonk et al, 2006
  149. IL1B – interleukin 1, beta: Sap2 and Sap6 fungal proteins trigger IL1B and IL18 production through inflammasome activation, via NLRP3 and caspase-1 activation in monocyte-derived macrophages and dendritic cells Pietrella et al, 2013
  150. IL1RN interleukin 1 receptor antagonist: NLRP3 Inflammasome Activity during Candida Infection Is Negatively Regulated by IL-22 via Activation of NLRC4 and IL-1Ra Borghi et al, 2015
  151. IL2 – interleukin 2 : Binds to C.Albicans Zanetta et al, 1998
  152. IL3- interleukin 3: IL-3 up-modulates MR, Dectin-1, and DC-SIGN, thus allowing more efficient fungal uptake/phagocytosis in macrophages Cardone et al, 2014.
  153. IL4 interleukin 4 : Candida albicans induced IL4, CCL22, IFN-gamma and IP10 secretion in peripheral blood mononuclear cells Kanda et al, 2002
  154. IL6 interleukin 6: Candida albicans PLM increased the mRNA expressions and secretions of proinflammatory cytokines (IL6) and chemokines (IL8) in THP-1 cells Chen et al, 2011
  155. IL10 interleukin 10: Fungal chitin dampens inflammation through IL10 induction mediated by NOD2 and TLR9 activation Wagener et al, 2014
  156. IL12A IL12B Interleukin 12 (dimer) induced by Candida albicans or Saccharomyces cerevisiae Biondo et al, 2012
  157. IL13 may play an important immunoregulatory role against C. albicans Katsifa et al, 2011.
  158. IL15 genes encoding IL15, the IL13RA1, and CD14 were suppressed during the 18-h exposure to C. albicans normal human monocytes Kim et al, 2005
  159. IL13RA1 interleukin 13 receptor subunit alpha 1: genes encoding IL15, the IL13RA1, and CD14 were suppressed during the 18-h exposure to C. albicans normal human monocytes Kim et al, 2005
  160. IL17A – interleukin 17A: induces artificial nutrient starvation conditions in Candida albicans Zelante et al, 2012 IL-17 pathway regulates antifungal immunity through upregulation of proinflammatory cytokines, including IL6, and neutrophil-recruiting chemokines (e.g., CXCL1 and CXCL5), and antimicrobial peptides Conti and Gaffen, 2015
  161. IL17RC interleukin 17 receptor C: required for in vivo IL-17-dependent responses during oral mucosal infections caused by Candida albicans Ho et al, 2015
  162. IL18 – interleukin 18 (interferon-gamma-inducing factor): Sap2 and Sap6 fungal proteins trigger IL1B and IL18 production through inflammasome activation, via NLRP3 and caspase-1 activation in monocyte-derived macrophages and dendritic cells Pietrella et al, 2013
  163. IL22 interleukin 22 : IL-22 and IDO1 are crucial in balancing resistance with tolerance to Candida infection De Luca et al, 2015
  164. IL33 interleukin 33: IL-33 Enhances Host Tolerance to Candida albicans Kidney Infections through Induction of IL-13 Production by CD4+ T Cells Tran et al, 2015
  165. IL34 interleukin 34 : Suppresses Candida albicans Induced TNFa Production in M1 Macrophages by Downregulating Expression of Dectin-1 and TLR2 Xu et al, 2015.
  166. IL36RN interleukin 36 receptor antagonist: Reduces Candida-Induced Th17 Responses van de Veerdonk et al, 2012.
  167. IL37 interleukin 37: interferes with the innate protective anti-Candida host response by reducing the production of proinflammatory cytokines and suppressing neutrophil recruitment in response to Candida van de Veerdonk et al, 2015
  168. IL1F10 interleukin 1 family member 10 (theta): (IL38) inhibits Candida-induced Th17 cytokine production via IL1RL2 (interleukin 1 receptor-like 2) van de Veerdonk et al, 2012.
  169. INPP5D inositol polyphosphate-5-phosphatase D: endogenous INPP5D relocated to live or heat-killed Candida albicans-containing phagosomes in a Dectin-1-dependent manner in GM-CSF-derived bone marrow cells Blanco-Menéndez et al, 2015
  170. IRAK1 interleukin 1 receptor associated kinase : C. albicans-induced endothelial NF-B-dependent gene expression requires IRAK1 and MyD88 Müller et al, 2007
  171. IRAK4 interleukin 1 receptor associated kinase 4 : infection of macrophages with C. albicans, A. flavus, or A. fumigatus abrogated the expression of the TLR signaling adaptors, IRAK1, IRAK4 and MyD88 Trinath et al, 2014.
  172. IRF1 interferon regulatory factor 1 : mice lacking TLR7 or IRF1 were hypersusceptible to systemic C. albicans infection Biondo et al, 2012
  173. IRF5 interferon regulatory factor 5 : Dectin-1-induced IFN-ß production , by C. Albicans, required the tyrosine kinase Syk and the transcription factor IRF5 del Fresno et al, 2013
  174. Iron Host iron is an essntial nutrient for C.Albicans Ramanan and Wang, 2002
  175. ITGAM – integrin, alpha M (complement component 3 receptor 3 subunit): ITGAM/ITGB2 is the principal adhesion receptor on leukocytes for Candida albicans Forsyth et al, 1998
  176. ITGB2 – integrin, beta 2 (complement component 3 receptor 3 and 4 subunit): ITGAM/ITGB2 is the principal adhesion receptor on leukocytes for Candida albicans Forsyth et al, 1998
  177. ITGAX ITGAX integrin subunit alpha X : Secreted aspartic protease 2 of Candida albicans inactivates factor H and the macrophage factor H-receptors CR3 (ITGAM/ITGB2 dimer ) and CR4 (ITGAX/ITGB2dimer ) Svoboda et al, 2015.
  178. KLKB1 kallikrein B1: high-molecular-mass kininogen (KNG1), F12 ,and prekallikrein - adhere to candidal cells Seweryn et al, 2015
  179. KLRK1 killer cell lectin-like receptor subfamily K, member : Innate immune receptors such as CD16, as well as the adhesion marker NCAM1 (CD56) or immunoreceptor tyrosine-based activating motif (ITAM)-bearing receptors such as NCR1 (CD335) and KLRK1 (CD314) were down-regulated on natural killer (NK) cells after interaction with C.Albicans Voight et al, 2014.
  180. KNG1 kininogen 1: high-molecular-mass kininogen (KNG1), F12 ) and prekallikrein (PPK) - adhere to candidal cells Seweryn et al, 2015
  181. lactosylceramide: Cryptococcus neoformans, Candida albicans, and other fungi bind specifically to lactosylceramide Jimenez-Lucho et al, 1990
  182. LAMA5 laminin subunit alpha 5: degraded by Candida proteinases Pärnänen et al, 2009
  183. LAMB3 laminin subunit beta 3: degraded by Candida proteinases Pärnänen et al, 2008
  184. LAMP1 lysosomal-associated membrane protein : Phagosomal exit controlled by C.Albicans Fernández-Arenas et al, 2009
  185. LCN2 – lipocalin 2: Knockout reduces resistance to C.Albicans and bacterial pathogens in mice Liu et al, 2013
  186. LCP1 lymphocyte cytosolic protein 1 (L-plastin) : Protein levels increased in infected mouse macrophages Martínez-Solano et al, 2006
  187. LEP Leptin: circulating leptin levels reduced post-infection in rats Rodríguez-Galán et al, 2010
  188. LGALS3 – lectin, galactoside-binding, soluble, 3: induces death of Candida species expressing specific beta-1,2-linked mannans Cohatsu et al, 2006.
  189. LCN2 lipocalin 2: enhanced sensitivity of LCN2(-/-) mice to both intracellular (Listeria monocytogenes) and extracellular (Candida albicans and Staphylococcus aureus) pathogens Liu et al, 2013
  190. LTA lymphotoxin alpha: TNF and LTA are critical to the stimulation of effector cells that leads to elimination of Candida from abscesses Vonk et al, 2002
  191. LTF – lactotransferrin: fungicidal effect on Candida albicans Nikawa et al, 1993
  192. LYZ – lysozyme: fungicidal effect on Candida albicans Samaranayake et al, 1997
  193. MALT1 MALT1 paracaspase: Engagement of Dectin-1 by fungal ß-glucans leads to subsequent association of the Syk tyrosine kinase inducing the assembly of a scaffold consisting of CARD9, BCL10, and MALT1 Hara and Saito, 2009
  194. MAP1LC3A microtubule associated protein 1 light chain 3 alpha: Dectin-1-dependent MAP1LC3A recruitment to phagosomes enhances fungicidal activity in macrophages Tam et al, 2014.
  195. MAP2K1 mitogen-activated protein kinase kinase 1: activated by C.Albicans Liu et al, 2015
  196. MAP3K7 mitogen-activated protein kinase kinase kinase 7: TRAF6 and MAP3K7 play essential roles in C-type lectin receptor signaling in response to Candida albicans infection .Gorjestaniet al, 2012.
  197. MAPK1 mitogen-activated protein kinase 1: Induced by C.Albicans in human polymorphonuclear neutrophils Zhong et al, 2003
  198. MAPK3 mitogen-activated protein kinase : Candida albicans induces PTGS2 expression and prostaglandin E2 production in synovial fibroblasts through an extracellular-regulated kinase 1/2 dependent pathway Lee et al, 2009.
  199. MAPK8 mitogen-activated protein kinase 8 : activated by C.Albicans Liu et al, 2015
  200. MARCO macrophage receptor with collagenous structure: MARCO participates in the uptake of both zymosan and C. albicans by CpG-ODN-pretreated, but not untreated macrophages in mice Józefowski et al, 2012
  201. MASP2 – mannan-binding lectin serine peptidase 2: complex formation between recombinant collectin-11 and recombinant MASP-2 on Candida albicans leads to deposition of C4b Ma et al, 2013
  202. MBL2 mannose-binding lectin (protein C) 2, soluble: binds to C.Albicans van Asbeck et al, 2008
  203. MDK – midkine (neurite growth-promoting factor 2): has fungicidal activity against Candida albicans and Candida parapsilosis Nordin et al, 2012
  204. MMP2 matrix metallopeptidase 2: activated by C.Albicans in human oral epithelial cells Claveau et al, 2004.
  205. MMP9 matrix metallopeptidase 9: activated by C.Albicans in human oral epithelial cells Claveau et al, 2004.
  206. MPO myeloperoxidase: MPO knockout mice were primarily susceptible to C. albicans infection Suzuki, 2002
  207. MRC1 mannose receptor, C type 1 (CD206): Mediates C.Albicans entry in human dendritic cells Donini et al, 2007
  208. MSR1 macrophage scavenger receptor 1 : involved in both the binding and phagocytosis of S. cerevisiae and Candida albicans Wang et al, 2010
  209. MTA2 metastasis associated 1 family member 2 :MTA2, IL2 and IL4 increase upon stimulation with C. albicans in mouse bone marrow derived dendritic cells Tierney et al, 2012
  210. MTOR mechanistic target of rapamycin (serine/threonine kinase): Protection against epithelial damage during Candida albicans infection is mediated by PI3K/Akt and MTOR signaling Moyes et al, 2014.
  211. MYD88 myeloid differentiation primary response 88: C. albicans-induced endothelial NF-B-dependent gene expression requires IRAK1 and MyD88 Müller et al, 2007
  212. MUC7 – mucin 7, secreted: Binds to C.Albicans Hoffman and Haidaris, 1993
  213. NADPH oxidase: Comprised of CYBA CYBB NCF1 NCF2 NCF4 Involved in C.Albicans killing Gazendam et al, 2014
  214. NCR1 N-acetyl-neuraminic acid: C. albicans is coated with sialic acids. N-acetyl-neuraminic acids are alpha2,6- and alpha2,3-linked Soares et al, 2000
  215. NCAM1 neural cell adhesion molecule 1 : Innate immune receptors such as CD16, as well as the adhesion marker NCAM1 (CD56) or immunoreceptor tyrosine-based activating motif (ITAM)-bearing receptors such as NCR1 (CD335) and KLRK1 (CD314) were down-regulated on natural killer (NK) cells after interaction with C.Albicans Voight et al, 2014.
  216. NCR1 natural cytotoxicity triggering receptor 1: Innate immune receptors such as CD16, as well as the adhesion marker NCAM1 (CD56) or immunoreceptor tyrosine-based activating motif (ITAM)-bearing receptors such as NCR1 (CD335) and KLRK1 (CD314) were down-regulated on natural killer (NK) cells after interaction with C.Albicans Voight et al, 2014.
  217. NFKB1 – nuclear factor of kappa light polypeptide gene enhancer in B-cells 1: C. albicans activates NF-kappaB and AP-1 (FOS) in OE21 cells Steubesand et al, 2009
  218. NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha: Involved in fungal activation of chemokine expression in endothelial cells Müller et al, 2007
  219. NID1 nidogen 1: binds to C.Albicans. López-Ribot et al, 1994
  220. NLRC4 NLR family, CARD domain containing 4: mucosal expression of NLRP3 and NLRC4 is induced by Candida infection Tomalka et al, 2011
  221. NLRP3 – NLR family, pyrin domain containing 3: Sap2 and Sap6 fungal proteins trigger IL1B and IL18 production through inflammasome activation, via NLRP3 and caspase-1 activation in monocyte-derived macrophages and dendritic cells Pietrella et al, 2013
  222. NLRP10 NLR family, pyrin domain containing 10 : essential for protective antifungal adaptive immunity against Candida albicans Joly et al, 2012.
  223. NOD2 nucleotide binding oligomerization domain containing : Fungal chitin dampens inflammation through IL10 induction mediated by NOD2 and TLR9 activation Wagener et al, 2014
  224. NOA1 nitric oxide associated 1: Downregulated in macrophages by C.Albicans Kitahara et al, 2015
  225. NOS2 nitric oxide synthase 2, inducible : macrophage NOS2 suppressed by C.Albicans Schröppel et al, 2001
  226. NPY neuropeptide Y: PYY and NPY stimulate macrophage function, including C.Albicans ingestion De la Fuente et al, 1993
  227. NR5A2 nuclear receptor subfamily 5 group A member 2: Mice with NR5A2 -deficient macrophages are highly susceptible to gastrointestinal and systemic Candida albicans infection
  228. OCLN occludin: Levels of occludin, E-cadherin, and desmoglein-2 reduced by C.Albicans in human intestinal epithelial monolayers Frank and Hostetter, 2007.
  229. Oestrogen: a fungal estrogen-binding protein binds mammalian estrogens with high affinity Madani et al, 1994
  230. PAK1 p21 protein (Cdc42/Rac)-activated kinase 1 Induced by C.Albicans in human polymorphonuclear neutrophils Zhong et al, 2003
  231. PARP1 poly(ADP-ribose) polymerase 1: involved in C.albicans induced apoptosis in oral epithelial cells Villar et al, 2012
  232. PDGFA platelet-derived growth factor alpha polypeptide, and PDGFB : peptides derived from HBEGF, amphiregulin, hepatocyte growth factor, PDGF-A and PDGF-B, as well as various FGFs are antimicrobial and antifungal Malmsten et al, 2007
  233. PDIA3 protein disulfide isomerase family A member 3: Protein levels decreased in infected mouse macrophages Martínez-Solano et al, 2006
  234. PGLYRP2 peptidoglycan recognition protein: suppresses colony-forming units of Candida albicans in vitro. PGLYRP3 and PGLYRP4 induced by C.Albicans in corneal epithelial cells Hua et al, 2015
  235. PENK proenkephalin: Met-enkephalin, Leu-enkephalin, and beta-endorphin reduced the expression of vimentin filaments in human monocytes and their phagocytic activity versus C.Albicans Prieto et al, 1989,
  236. PIAS1 protein inhibitor of activated STAT 1: infection of macrophages with C. albicans, A. flavus, and A. fumigatus induced robust activation of WNT5A signaling and increased expression of PIAS-1 and SOCS-1 Trinath et al, 2014.
  237. PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha: activated by C.Albicans Liu et al, 2015
  238. PLA2G4A phospholipase A2 group IVA: activated by C.Albicans in alveolar macrophages Parti et al, 2010
  239. PLG – plasminogen: binds to fungal Pra1 Luo et al, 2009
  240. Polyamines: Host putrescine required for hyphae formation Herrero et al, 1999 and the fungus possesses a spermidine uptake system (DUR31) Meyer et al, 2012
  241. POMC – proopiomelanocortin: Precursor for multiple peptides including alpha-MSH which has antifungal effects versus C.Albicans Catania et al, 2006
  242. PPARG peroxisome proliferator-activated receptor gamma : pioglitazone-treated mice were strongly protected against lethal Ca challengeMajer et al, 2012.
  243. PPBP pro-platelet basic protein antifungal protein Kwakman et al, 2011
  244. PRF1 Perforin has antifungal activity Voight et al, 2014.
  245. PRKCA protein kinase C, alpha: involved in phagocytosis of complement-opsonized Candida albicans Ma et al, 2015
  246. PRKCD protein kinase C, delta: Candida albicans-induced cytokine production was blocked in Prkcd(-/-) cells, and Prkcd(-/-) mice were highly susceptible to fungal infection Strasser et al, 2012.
  247. PSMB8 proteasome subunit beta 8: Inhibition of this immunoproteosome component results in increased susceptibility to systemic candidiasis Mundt et al, 2016
  248. PTAFR platelet-activating factor receptor: activation of the PAF pathway is crucial for PUVA-induced immune suppression (as measured by suppression of delayed type hypersensitivity to Candida albicans) Wolf et al, 2006
  249. PTEN phosphatase and tensin homolog : PTEN directly activates the actin depolymerization factor cofilin-1 during PGE2-mediated inhibition of phagocytosis of fungi Serezani et al , 2012.
  250. PTGER2 prostaglandin E receptor 2: Prostaglandin E2 suppressed fungal phagocytosis and F-actin formation through the PGE(2) receptors PTGER2 and EP4 Serezani et al , 2012
  251. PTGER4 prostaglandin E receptor 4 : Prostaglandin E2 suppressed fungal phagocytosis and F-actin formation through the PGE(2) receptors PTGER2 and EP4 Serezani et al , 2012
  252. PTGIR prostaglandin I2 (prostacyclin) receptor (IP) : Expression increased in C.Albicans treated macrophages Suram et al, 2015
  253. PTK2 protein tyrosine kinase 2: Activated by C.Albicans in keratinocytes Shi et al, 2009
  254. PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) : macrophages infected with Candida albicans, Aspergillus flavus or Aspergillus fumigatus or treated with Curdlan, a selective agonist of pattern recognition receptor for fungi Dectin-1, displays increased expression of ALOX5, ALOX15 and PTGS2 Karnam et al, 2015.
  255. PTPN11 protein tyrosine phosphatase, non-receptor type 11: dendritic cell-derived PTPN11 was crucial for the induction of interleukin 1ß (IL-1ß), IL-6 and IL-23 and anti-fungal responses of the TH17 subset of helper T cells in controlling infection with Candida albicans Deng et al, 2015.
  256. PTX3 pentraxin 3 : upregulated by C.Albicans in mouse bone marrow-derived macrophages and bone marrow-derived dendritic cells Tierney et al, 2012
  257. PYY peptide YY: PYY and NPY stimulate macrophage function, including C.Albicans ingestion De la Fuente et al, 1993
  258. RAB5A RAB5A, member RAS oncogene family: recruited to phagosomes containing C. albicans Okai et al, 2015
  259. RAB7A, member RAS oncogene family: recruited to phagosomes containing C. albicans Okai et al, 2015
  260. RAB14 RAB14, member RAS oncogene family: Phagosomes containing live C. albicans cells became transiently Rab14 positive within 2 min following engulfment Okai et al, 2015
  261. RAB27A RAB27A, member RAS oncogene family: Serum-treated Candida albicans triggers neutrophil extracellular trap formation in a reactive oxygen species -dependent manner, and Rab27a-knockdown inhibits this process Kawakami et al, 2014
  262. RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1): Expression of dominant-negative Rac1 or Cdc42 eliminated C albicans- mediated ERK phosphorylation and phagocytosis and granule migration toward the ingested microbes Zhong et al, 2003
  263. RASGRF1 Ras protein specific guanine nucleotide releasing factor 1: CARD9 mediates Dectin-1-induced ERK activation by linking Ras-GRF1 to H-Ras for antifungal immunity Jia et al, 2014.
  264. RNASE7 ribonuclease, RNase A family, 7: defends against C.Albicans independently of RNASE activity Swidergall and , Ernst 2014
  265. RORC RAR-related orphan receptor C: Impairment of immunity to Candida and Mycobacterium in humans with bi-allelic RORC mutations Okada et al, 2015
  266. RPL7L1 : interacts with C.Albicans in macrophages (as do NOA1
    HSPA1A C3 and LUM) Kitahara et al, 2015
  267. RUBCN RUN domain and cysteine-rich domain containing, Beclin 1-interacting protein: Has a Negative Effect on Host Antifungal Activity Yang et al, 2012
  268. S100A8 S100 calcium binding protein A8 Calprotectin (S100A8/S100A9 dimer) has antifungal activity Cederlund et al, 2010
  269. S100A9 S100 calcium binding protein A9 (calgranulin) : Cederlund et al, 2010
  270. S100A12 S100 calcium binding protein A12: has antifungal activity against Candida albicans, C. krusei, C. glabrata and C. tropicalis Cunden et al, 2016
  271. SCAF11 SR-related CTD-associated factor 1 (caspase 11): caspase-1 and caspase-11 connect the canonical and noncanonical pathways of inflammasome activation in response to C. albicans S-aspartyl proteases Gabrielli et al, 2015.
  272. SCARF1 – scavenger receptor class F, member 1: SCARF1 and CD36, mediate host defense against Cryptococcus neoformans and Candida albicans Means et al, 2009
  273. SELPLG selectin P ligand: epithelial expression stimulated by C.Albicans Schaller et al, 2002
  274. SEPT7 septin 7: accumulates with N-cadherin and actin microfilaments around C. albicans as it was endocytosed by endothelial cells Phan et al, 2013
  275. Serotonin: 5-HT treatment of C. albicans significantly affected hyphal extension suggesting an antifungal effect Mayr et al, 2005
  276. SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1: cleaved by a fungal secreted aspartyl proteinase Gogol et al, 2015
  277. SFTPD surfactant protein D: inhibited phagocytosis of C. albicans by alveolar macrophages van Rozendaal et al, 2000
  278. SIGIRR single immunoglobulin and toll-interleukin 1 receptor (TIR) domain: Inflammatory pathology and susceptibility to infection were higher in SIGIRR (-/-) mice Bozza et al, 2008
  279. SIGLEC7 sialic acid binding Ig-like lectin 7: Binds to C.Albicans Varchetta et al, 2012
  280. SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1 (nramp1): recruited from tertiary granules to the phagosomal membrane on phagocytosis of C.Albicans Canonne-Hergaux et al, 2002
  281. SLPI secretory leukocyte peptidase inhibitor: has fungicidal activity toward metabolically active A. fumigatus conidia and C. albicans yeast cells Tomee et al, 1997;
  282. SOCS1 suppressor of cytokine signaling 1: enhances the maturation and antifungal immunity of dendritic cells in response to Candida albicans Shi et al, 2015
  283. SOCS3 suppressor of cytokine signaling 3 : regulated in human monocytes exposed to C.Albicans: up-regulated at 4 to 6 h and remained elevated throughout the 18-h time courseKim et al, 2005
  284. Sphingolipids: Candida albicans was susceptible to sphinganine, sphingosine, dimethylsphingosine, and to a lesser degree, stearylamine Bibel et al, 1993 and to phytosphingosine Veerman et al, 2010
  285. SPP1 secreted phosphoprotein 1: The prophylactic provision of micafungin prior to Candida albicans infection was characterized by an increase in the proinflammatory cytokines CXCL13 and SPP1 Fuchs et al, 2016
  286. SPTLC2 serine palmitoyltransferase, long chain base subunit 2: Sptlc2-/- DC2.4 cells exhibited a stark defect in phagocytosis, were unable to bind fungal particles and failed to form a normal phagocytic cup to engulf C. albicans .
  287. SQSTM1 involved in the autophagy and chemokine response to C.Albicans (=p62 in this paper) Kanayama et al, 2015
  288. STATH statherin salivary protein that induces transition of hyphae to yeast Leito et al, 2009
  289. STX4 syntaxin 4: VAMP3, ADAM17 and STX4 incolved in the movement of TNF to the phagosomal cup during C.Albicans phagocytosis Murray et al, 2005
  290. SYK spleen tyrosine kinase : ß-glucans and Candida albicans induced Syk phosphorylation, and Syk inhibition significantly decreased ß-glucan-induced chemokine secretion from Intestinal epithelial cells Cohen-Kedar et al, 2014.
  291. TAC1 tachykinin precursor 1: Substance P has antifungal properties Kowalska et al, 2002
  292. TFPI antimicrobial against the gram-negative bacteria Escherichia coli and Pseudomonas aeruginosa, gram-positive Bacillus subtilis and Staphylococcus aureus, as well as the fungi Candida albicans and Candida parapsilosis Papareddy et al, 2010
  293. TFRC transferrin receptor : regulated in human monocytes exposed to C.Albicans: up-regulated at 4 to 6 h and remained elevated throughout the 18-h time courseKim et al, 2005
  294. TGFB1 transforming growth factor beta 1: hepcidin induction by heat-killed Candida albicans hyphae was IL-6-independent, but partially TGF-ß-dependent Armitage et al, 2011
  295. THBS1 thrombospondin 1: enhances the early innate immune response against C. albicans and promotes activation of inflammatory macrophages (NOS1, IL6, TNF-a, IL10), release of the chemokines MIP-2, CCL2 MIP-1a, and RANTES, and CXCR2-driven polymorphonuclear leukocytes recruitment Martin-Manso et al, 2012
  296. thromboxane B2 significantly enhanced serum-induced germination by C. albicans Noverr and Huffnagle, 2004.
  297. TICAM1 toll-like receptor adaptor molecule 1: Functional yet balanced reactivity to Candida albicans requires TICAM1, MyD88, and IDO-dependent inhibition of RORC De Luca et al, 2007.
  298. TIMP1 TIMP metallopeptidase inhibitor 1: Cell fractions of Candida albicans, C. parapsilosis Cp2, Candida glabrata reference strain, and Candida krusei fragmented TIMP1 (28 kDa) to a 24-kDa species Pärnänen et al, 2011
  299. TLR2 toll-like receptor 2 :TLR2 and TLR4, acting via the adapter protein MyD88, signal responses to Cryptococcus neoformans, Aspergillus fumigatus and Candida albicans in vitro Levitz, 2004
  300. TLR3 C. albicans-induced CXCL8/IL-8 expression in endothelial cells is mediated by TLR3 rather than TLR2 and TLR4 Müller et al, 2007
  301. TLR4 toll-like receptor 4 : TLR2 and TLR4, acting via the adapter protein MyD88, signal responses to Cryptococcus neoformans, Aspergillus fumigatus and Candida albicans in vitro Levitz, 2004
  302. TLR6 toll-like receptor 6 : recognition of C. albicans by TLR6 modulated the balance between Th1 and Th2 cytokines Netea et al, 2008
  303. TLR7 toll-like receptor 7: partially required for the induction of IL12A/IL12B by Candida albicans or Saccharomyces cerevisiae Biondo et al, 2012
  304. TLR9 Toll-like receptor 9: TLR9 recruitment to the macrophage phagosomal membrane is a conserved feature of fungi of distinct phylogenetic origins, including Candida albicans, Saccharomyces cerevisiae, Malassezia furfur, and Cryptococcus neoformans Kasperkovitz et al, 2011 .
  305. TNC tenascin C: Binds to C. albicans cell wall materials López-Ribot et al, 1999
  306. TNF The Candida albicans phospholipomannan induces in vitro production of TNF from human and murine macrophages Jouault et al, 1994.
  307. TNFSF18 tumor necrosis factor superfamily member 18: during fungal infection, TNFSF18/TNFRSF18 interaction modulates TLR-4 and TLR-2 expression Vecchiarelli et al, 2009
  308. TNFRSF18 tumor necrosis factor receptor superfamily member 18 : during fungal infection, TNFSF18/TNFRSF18 interaction modulates TLR-4 and TLR-2 expression Vecchiarelli et al, 2009
  309. TPM3 tropomyosin 3 : Protein levels increased in infected mouse macrophages Martínez-Solano et al, 2006
  310. TRAF6 TNF receptor associated factor 6: TRAF6 and MAP3K7 play essential roles in C-type lectin receptor signaling in response to Candida albicans infection .Gorjestaniet al, 2012.
  311. UBASH3A ubiquitin associated and SH3 domain containing A: Functional inactivation leads to profound resistance to systemic infection by C. albicans Naseem et al, 2015
  312. UBASH3B ubiquitin associated and SH3 domain containing B: Functional inactivation leads to profound resistance to systemic infection by C. albicans Naseem et al, 2015
  313. VAMP3 vesicle associated membrane protein 3: VAMP3, ADAM17 (Tace) and STX4 incolved in the movement of TNF to the phagosomal cup during C.Albicans phagocytosis Murray et al, 2005
  314. VAV1 vav guanine nucleotide exchange factor 1: BTK and Vav1 contribute to Dectin1-dependent phagocytosis of Candida albicans in macrophages Strijbis et al, 2013
  315. VAV3 vav guanine nucleotide exchange factor 3: Vav1,3-deficient mice have increased susceptibility to systemic candidiasis Li et al, 2011
  316. VIP vasoactive intestinal polypeptide : stimulates macrophage function, including C.Albicans ingestion De la Fuente et al, 1993
  317. VSIG4 V-set and immunoglobulin domain containing 4: involved in phagocytosis of complement-opsonized Candida albicans Ma et al, 2015
  318. VTN – vitronectin: binds to C. albicans Limper and Standing, 1994
  319. WASL Wiskott-Aldrich syndrome-like: Involved in fungal endocytosis in human endothelial cells Shintaku et al, 2013
  320. WNT5A wingless-type MMTV integration site family member 5A : infection of macrophages with C. albicans, A. flavus, and A. fumigatus induced robust activation of WNT5A signaling and increased expression of PIAS-1 and SOCS-1 and GSK3B phosphorylation Trinath et al, 2014.
  321. XIAP X-linked inhibitor of apoptosis: Xiap(-/-) mice became highly vulnerable toCandida albicans infection Hsieh et al, 2014.
  322. ZC3H12A zinc finger CCCH-type containing 12A (MCPIP1): ZC3H12A haploinsufficient mice showed enhanced resistance to disseminated Candida albicans infection Garg et al, 2015\
  323. Zinc scavenged by C.Albicans Citiulo et al, 2012
  324. Candida albicans can use use propionate and valerate as carbon sources and is able to detoxify propionyl-CoA Otzen et al, 2014.
  325. Candida permeases take up Arginine Proline Methionine Leucine Valine Isoleucine Phenylalanine Tryptophan Threonine Tyrosine citrulline Kraidlova et al, 2011

Delta-9-tetrahydrocannabinol decreases the efficacy of the memory immune response to candida infection Blumstein et al, 2014

Polymorphisms associated with Candida Albicans infection. (CCL3, CCL4, CCL20, CXCL2, CXCL8, CXCL10, CCR1, and CCR2) Loeffler et al, 2010

Fungal Immune Evasion in a Model Host–Pathogen Interaction: Candida albicans Versus Macrophages

 

Bulk experiments

Functional genomics identifies type I interferon pathway as central for host defense against Candida albicans.Smeekens et al, 2013

Candida-response signature: ADAR APOL3 C20orf18 CCL8 CD38 CD40 CHMP5 CXCL10 CXCL9 DDX58 DNAPTP6 DYNLT1 EIF2AK2 EPSTI1 FAM46A FAS FBXO6 FLJ11000 FLJ11286 FLJ20035 FTSJD2 G1P3 GBP1 GBP2 GBP4 GBP5 GZMB HAPLN3 HERC5 HERC6 IFI27 IFI35 IFI44 IFI44L IFI6 IFIH1 IFIT2 IFIT3 IFIT5 IFITM1 IFITM2 IFITM3 IFNG IRF1 IRF7 IRF8 ISG15 ISG20 KIAA1618 LAG3 LAMP3 LAP3 LBA1 LFNG LGALS9 LGP2 LINCR LTA LY6E MX1 NCOA7 OAS1 OAS2 OAS3 PARP10 PARP12 PARP14 PARP9 PHF11 PRF1 PRIC285 PSMB8 PSMB9 RGC32 RSAD2 RTP4 SAMD9L SOCS1 SP110 STAT1 STAT2 STOM TAP1 TMEM126B TNFSF10 TNFSF13B TRAFD1 TRIM21 TRIM22 TRIM5 UBE2L6 WARS XAF1 XRN1 ZBP1

Candida albicans Shaving to Profile Human Serum Proteins on Hyphal Surface Marín et al, 2015.

Human proteins of complement and coagulation pathways and serpins identified on the surface of C. albicans after incubation with human serum. A2M APOH C1QA C1QB C1QC C1R C1RL C1S C2 C3 C4A C4B C4BPA C4BPB C5 C6 C7 C8A C8B C8G C9 CFB CFD CFH CFI CFP CLU COLEC11 CPB2 F10 F12 F13A F13B F2 F5 F7 F9 FCN2 FCN3 FGA FGB FGG FN1 GP5 GPLD1 HABP2 HBB HCF2 HPA HRG KLKB1 KNG1 MASP2 PLG PROC PROS1 SERPINA1 SERPINA3 SERPINA4 SERPINA5 SERPINA6 SERPINA7 SERPINA8 SERPINA10 SERPINC1 SERPIND1 SERPINF1 SERPINF2 SERPING1 SERPINA10 SERPING1 VTN VWF

Human proteins not involved in complement and coagulation pathways identified on C. albicans surface after incubation with10% human serum

A1BG ACTB ACTBL2 ACTC1 ACTN1 AFM AGF AGT AHSG ALB AMBP ANK1 ANTXR2 APMAP APOA1 APOA2 APOA4 APOA5 APOB APOC1 APOC2 APOC3 APOC4 APOE APOF APOL1 APOM ARF3 BPIFB1 BTD CD14 CD5L CDH5 CETP CNDP1 COLEC10 CP CPN1 CPN2 CTSG ECM1 EEF1A1 EEF2 EFEMP1 EPB42 EPB72 FBLN1 FERMT3 FETUB FLN GAPDH GC GPX3 GSN HBA2 HIST1H2AH HIST1H2BK HIST1H4 HP HPR HPX HRNR HSP90B HSPA1L HSPA2 HSPA5 HSPA6 HSPA8 IGFALS IGHA1 IGHA2 IGHD IGHG1 IGHG2 IGHG3 IGHG4 IGHM IGJ IGKC IGLC1 IGLC2 IGLL5 ITGA2B ITGB3 ITIH1 ITIH2 ITIH3 ITIH4 KRT1 KRT10 KRT2 KRT6B KRT9 LBP LCAT LGALS3BP LPA LRG1 LUM MST1 PCL1 PF4 PFN1 PGRPL PLEK PLPT PON1 PON3 PRDX6 PRG4 QSOX1 RAP1BL RBP4 RPL8 SAA4 SEPP1 SERPINA3 SERPINA4 SERPINA6 SERPINA7 SERPINF1 SHBG SLC4A1 SPP2 SPTA SPTB TALDO1 TF TGM2 THBS1 TLN1 TSKU TTR TUBA4A TUBB VCL YWHAQ YWHAZ

New signaling pathways govern the host response to C. albicans infection in various niches. Liu et al, 2015

Upregulated in epithelial &/or endothelial cells (at least 1 time point): AGT APP CD40LG CHUK CREB1 CSF1 CSF2 CXCL12 EDN1 EGF ERBB2 F2 FGF2 FOXO1 GSM HGF HIF1A IFNG IGF1 IKBKG IL15 IL17A IL1A IL1B IL3 IL4 IL5 IL6 MAPK1 MAPK14 MAPK3 MAPK8 MYD88 NEDD9 NFKB1 NOTCH1 NUPR1 PDGFB PDX1 PPRC1 RAF1 RELA STAT3 STAT4 STAT6 SYVN1 TCR TGFB1 TICAM1 TLR3 TNF TNFSF11 TP53 TREM1 VEGFA

Down-regulated in epithelial &/or endothelial cells: COL18A1 CSF1 F2 IGG complex IL1A NKX2-3 RELA TNF VEGF complex

Mis-regulated PDGF and NEDD9 pathway targets in endothelial or epithelial cells (PDGFRB and NEDD9 mediate C.Albicans endocytosis) ACKR3 ADM ADRB2 ANKRD37 ATF3 BHLHE40 BMP2 BMP4 BNIP3 CCL2 CCL20 CEBPB CEBPD CTGF CXCL2 CXCL8 DDIT4 DUSP1 DUSP5 DUSP6 EDN1 EGR1 EGR2 ERRFI1 ETS2 F3 FOS FOSL1 FOXC2 GDF15 GDNF GEM GJA1 HBEGF IER3 INHBA JUN JUNB KLF10 LIF NFIL1 NFIL3 NR4A1 NR4A3 PIM1 PPARD PPP1R15A PPP1R3B PTGS2 RGS2 RHOB SLC2A1 SLC2A2 SLC2A3 SOCS3 STC1 VEGFA ZFP36

PDGF BB and NEDD9 are activated during disseminated candidiasis: misregulated target genes. ALOXE3 ATF3 BCL3 BHLHE40 CCL2 CD44 CEBPB CTGF CYR61 DDIT4 DUSP1 DUSP5 EDN1 EGR1 ELF3 ERRFI1 F3 FABP1 FOS GADD45A GDF15 IER2 IER3 IL1B JUNB KLF10 KLF6 LIF MCL1 MKNK2 MMP9 MYC NAMPT NR4A1 PCK1 PIM1 PLAC8 PLIN2 RGS2 RHOB RND3 SERPINE1 SGK1 SOCS3 TNFAIP3 TRIB1 TXNIP ZFP36

PDGF-target genes are induced during clinical episodes of vaginal candidiasis. BCL3
BHLHE40 BRAP CBX4 CD44 CEBPB CTGF DBNDD1 DUSP5 DUSP6 EDN1 EGR1 EGR2 F3 FOS IL1B IL8 JUNB NAMPT NR4A1 NR4A2 NR4A3 PHLDA1 PIN1 PLAU PPP1R15A RND3 SGK1 SLC2A3 SLCO1A2 SOCS3 SRF SYK THBS1 TNFAIP3 TRIB1

Integrated inference and evaluation of host-fungi interaction networks Remmele et al, 2015.

Host-pathogen PPI subnetworks between mouse and C.Albicans.

APP ATP4B AXL BMX CD4 CDH1 CDK5 COL14A1 COL7A1 CORO1A CTNNB1 DSP EGFR EPHA1 EPHA2 EPHA8 EPHB3 EPHB4 FERT2 FN1 ICAM1 IL1B INPPL1 ITGA4 ITGB5 JUP KIT LAMA4 LGALS1 LMO7 MERTK MLLT4 NLGN3 OLR1 PCDHA4 PDGFRA PDPK1 PKP4 PRKCE PSEN1 PXN RET RHOA ROCK1 SHC1 SLC7A11 SRC SYK TEK TNC TYRO3 VCAM1 VTN

Candida albicans induces pro-inflammatory and anti-apoptotic signals in macrophages as revealed by quantitative proteomics and phosphoproteomics Reales-Calderón et al, 2013

Differentially abundant proteins in macrophages during C. albicans interaction ABCC3 ACAA2 ACADM ACADVL BANF1 BPHL CAR2 CCDC127 CCDC167 CD14 CD36 CDV3 CKAP5 COA5 COQ9 CPOX CSF1R DHRSX ERLIN2 FABP4 FDX1 GLUT1 GOLGA2 HDHD3 HINT2 HMGCR KRT76 LAS1L LILRB4 MCL1 MPEG1 MPRPL4 MRPL21 MRPL22 MRPL23 MRPL32 MRPL44 MRPL51 MRPS21 NEMF NIP37 NONO OCIAD1 PDAP1 PEX11B PMPCB PRAF2 PYCR1 PYCR2 RETSAT RPF4 RTN4 SEC31B SELS SMDT1 SMPD4 SON SSRP1 TIMM23 TMEM33 TMX3 TOP2B TOR1AIP1 TYROBP UBA5 UBXN1 VCPIP1 VIM

Macrophage phosphopeptides that significantly increased in abundance in response to C. albicans A2APV2 A2RTL5 AAAT AGFG1 AMPD2 AP3D1 APBB1IP ARHGEF2 ARHGEF6 ARHGEF7 ATP6V0A2 ATXN2L BAT2 BAT2D BCKDK BCLAF1 BRF1 C20ORF30 C4ORF3 CBX8 CCDC88B CCNY CD2AP CD44 CDK4 CLASP1 COPA CSDA CYBA DDX21 DDX24 DDX24 DNAJC5 DOCK2 DOCK7 DOK1 EBAG9 EEF2 EHBP1L1 EIF3B EIF4G1 EPB41L2 EVI2B FAM82A2 FAM83H FCGR1 FIP1 FIP1L1 FMNL2 GALNT7 GOLGA5 HIST1H1C HIST1H1D HMGN1 HMHA1 HN1 HNRNPH1 INPP5D JUN KIF22 LARP1 LARP4B LCP1 LEMD3 LIMA1 LMNA LNP LRRFIP1 LSM14A MAN1 MAP4K6 MARCKSL1 MBP MCOLN1 MED24 MEF2C MSR1 MYBBP1A MYO5A MYO9B NCBP1 NCL NCOA3 NFATC2 NOP56 NP95 NPM1 NUCB1 NUCKS1 NUDT5 NVL PBXIP1 PGRMC1 PHKA2 PKN1 PLCB3 PLEKHO2 PPHLN1 PRPF4B PSEN1 PSMF1 PTPN6 PTPRA RAB7A RALY RANBP2 RBL1 RBM14 RFC1 RSRC2 RTN4 SAP30 SASH3 SCAMP3 SCN10A SERBP1 SFRS9 SGPP1 SLC16A1 SLC1A5 SLC35C2 SLC43A2 SLIRP SNAP23 SPP1 SRRM2 SSR1 SSR3 STMN1 STT3B STX4 TBC1 TBC1D10B TBC1D15 TCOF1 THRAP3 TMEM230 TMPO TMX1 TNS3 TOMM70A TOP2B TRAM1 TREX2 TRIM65 TUBGCP2 TWF2 UFL1 USP10 VAMP4 VASP YBX1 ZFP106 ZFR

Sub-proteomic study on macrophage response to Candida albicans unravels new proteins involved in the host defense against the fungus Reales-Calderón et al, 2012

Differentially abundant proteins of cytosolic, membrane and nuclear enriched fractions ACTB EEF2 EPRS HIST1H1A HNRPH1 HSP90B1 HSPA5 HSPD1 IMMT ISYNA1 LCP1 LGALS3 NAPA PDIA1 PDIA3 PDIA6 PITPNA PPIA PRDX1 PTGES3 PTPN6 UQCRC1 VIM

Proteomics of RAW 264.7 macrophages upon interaction with heat-inactivated Candida albicans cells unravel an anti-inflammatory response Reales-Calderón et al, 2009

ACTB ADSS2 ANXA1 ARHGDIB CAPG CCT8 CLIC1 EEF2 IF4A1 ENO1 ERP29 FTL1 HSPA9A IDH1 OXCT1 P4HB PKM2 PSMA1 RAN TPI TPM5 VIM YWHAZ

Candida albicans Triggers Activation of Distinct Signaling Pathways to Establish a Proinflammatory Gene Expression Program in Primary Human Endothelial Cells Müller et al, 2007

Upregulated:- CXADR CCL2 CCL20 CD24 CD69 CD74 CX3CL1 CXCL1 CXCL2 CXCL3 CXCL5 CXCL8 CXCR7 F3 ICAM1 VCAM1 KLF4, ZFP36 ZNF151 LIN28A

Expression of genes encoding innate host defense molecules in normal human monocytes in response to Candida albicans Kim et al, 2005.

Misregulated genes: ADORA2A ADORA2B BCL2A1 CCL13 CCL18 CCL2 CCL20 CCL4 CCR1 CCR2 CCR5 CCR7 CD14 CD80 CD83 CSF1 CSF2 CXCL1 CXCL3 CXCR5 GJB2 GJB3 HSP90AB1 HSPA2 HSPA8 HSPD1 HSPE1 ICAM1 IL13RA1 IL15 IL1A IL1B IL1RN IL23A IL6R IL8 LIF MT1G MT1H MT1L MT2A PECAM1 PTGS2 SOCS3 TFRC TNF XIAP

The Fungal Quorum-Sensing Molecule Farnesol Activates Innate Immune Cells but Suppresses Cellular Adaptive Immunity Leonhardt et al, 2015 (Farnesol is a quorum-sensing molecule produced by C.Albicans)

Effects of farnesol on gene expression in dendritic cells

Upregulated CCL2 CCL24 CCL26 CCL26 CCL7 CCL8 CCR1 CD14 CD1D CD300A CD300LF CD68 CD82 CR1 IL17RB

Downregulated AMICA1 CCL1 CCL19 CCL5 CD1A CD1E CD40 CD70 CLEC10A CLEC1A CLEC4A CSF2RA CXCL1 CXCL9 HLA-DQA1 HLA-DQB HLA-DRB3 HLA-DRB4 IL13RA1 IL15 IL1RAP IL28A IL28B IL29 MMP12 MMP25 SOCS2

Cytosolic Phospholipase A2a and Eicosanoids Regulate Expression of Genes in Macrophages Involved in Host Defense and Inflammation Suram et al, 2013

Genes increased by C. albicans in wild type resident mouse peritoneal macrophages ABCA1 ABL2 ACAP2 ACP5 ADAMTS9 ADM ADORA2A ADORA2B AFF4 AGPAT9 AGPAT9 AHR AI504432 AK4 AKAP2 AKAP2 ALCAM ANKRD33B ANKRD33B ANKRD37 APBB3 APOL8 ARC AREG ARHGAP26 ARID5A ARL4A ARL4A ARL5B ARL5B ARL5B ARL5B ARL5B ARRDC4 ASB4 ASB4 ASNS ATF3 ATF4 BASP1 BC031781 BCL2A1B BCL2A1C BCL2L11 BHLHE40 BLCAP BMP2 BMP6 BNIP3 C87414 CAR13 CBLN3 CCL2 CCL3 CCL4 CCL7 CCL7 CCNF CCNG2 CCNO CCR1 CCRL2 CCRL2 CCRN4L CD244 CD24A CD80 CD83 CD86 CDKN1A CFLAR CFLAR CFLAR CFLAR CGREF1 CHAC1 CHAF1B CHST11 CHST11 CISH CLIC4 CLIC4 CLK4 COQ10B COQ10B COQ10B CPEB4 CREM CREM CREM CREM CREM CRY1 CRYBA4 CSF2 CSF3 CSRNP1 CSRNP1 CSRNP1 CTH CUEDC1 CXCL1 CXCL2 CXCL3 CXCR7 CYTIP DDIT4 DENR DGKG DNAHC2 DOT1L DPYS DUSP1 DUSP10 DUSP14 DUSP14 DUSP16 DUSP16 DUSP2 DUSP4 DUSP8 EAF1 EDIL3 EDN1 EEA1 EFNB2 EFNB2 EGLN3 EGR1 EGR2 EGR3 EID3 EIF1A EIF2C2 EIF2C2 EIF4E ELL2 EML1 EML1 EMP1 ENO2 ENO2 EPHA2 EPHA4 EPHA4 ERDR1 EREG ERO1L ERO1L ERRFI1 EXT1 F2R F3 F3 FABP3 FAM107B FAM107B FAM107B FAM110C FAM110C FAM162A FAM162A FAM198B FAM46C FAM78B FBXO30 FBXO30 FEM1B FEM1B FEM1C FEM1C FERMT2 FHAD1 FLRT3 FLRT3 FOSL1 FST FZD8 GABPB1 GADD45B GADD45B GADD45G GCH1 GCNT2 GDF15 GEM GFPT1 GFPT1 GFPT1 GJA1 GJA1 GLS2 GM129 GM15247 GM15247 GM15645 GM5662 GM6377 GM6742 GPR35 GPR35 GPRC5A GRASP GZMB HAVCR2 HBEGF HDC HECW2 HES1 HIGD1A HIVEP2 HIVEP3 HK1 HK1 HK1 HK1 HK2 HOMER1 HSD17B12 HSPA4L HSPA4L HSPA4L HSPA4L HTRA4 ID1 ID1 ID2 ID2 ID3 IER3 IFI205 IFRD1 IFRD1 IGF2BP1 IL10 IL17RA IL17RA IL1A IL1A IL1B IL1F6 IL1RN IL1RN IL23A IL6 IMPACT INHBA INHBB IRF4 ISG15 ITGAV ITGAV ITGAV ITGB3 JARID2 JARID2 JMJD6 JSRP1 JUNB JUNB KCTD12 KCTD12 KCTD4 KCTD4 KCTD6 KDELR3 KDM6B LDHA LFNG LIN54 LMNB1 LONRF3 LOXL2 LOXL2 LPAR1 LRP8 MACROD2 MAFF MAFK MALT1 MALT1 MAP3K2 MAPK15 MARCKSL1 MARCKSL1 MBD1 MCL1 MCM10 MDM2 MED13 MID1 MMP13 MMP3 MPZL1 MRPL52 MT2 MTHFD1L MTHFD2 MTMR7 MTMR7 MXD1 MXD1 MXI1 MYC MYC MYO1B NDRG1 NFKB1 NFKB1 NFKB1 NFKB1 NFKBIB NFKBID NIACR1 NKTR NPY NR4A1 NR4A2 NR4A3 NRG1 NUFIP1 OAF ODC1 ODC1 OLFR291 OLR1 OSGIN2 OSM OSM P2RY2 P2RY2 P4HA2 PABPC4 PABPC4 PBX1 PBX1 PCDHB4 PCF11 PCF11 PDE10A PDPN PDPN PENK PFKFB3 PFKFB3 PFKFB3 PFKP PGK1 PHLDA1 PHLDB1 PIGA PIGA PIM3 PITPNC1 PLA2G4A PLA2G4A PLA2G5 PLAGL1 PLAU PLAU PLAUR PLAUR PLCL1 PLCXD1 PLEK PLEK PLK2 PLK3 POU3F1 PPP1R15A PPP1R3B PPP1R3G PROCR PROK2 PROK2 PROSC PROSC PROZ PRR15 PSAT1 PTGES PTGS2 PTGS2 PTP4A1 PTP4A1 PTP4A1 PVR PVR PVR PVR QPCT RAB11FIP1 RAB11FIP1 RAB20 RAB44 RAB8B RAB8B RABGEF1 RAI14 RAI14 RAI14 RAI14 RALGAPA2 RALGDS RAMP3 RAPGEF2 RASGEF1B RCAN1 RCAN1 RCOR2 REL RELN RGS1 RLF RLF RLIM RND1 RSBN1 RSBN1 RUNX3 RYBP SAP30 SCX SDC4 SDC4 SEC24A SEMA6D SERPINA3F SERPINA3F SERPINE1 SESN2 SIAH2 SIPA1L1 SKIL SLA SLC15A3 SLC16A1 SLC16A3 SLC20A1 SLC25A25 SLC2A1 SLC38A1 SLC39A14 SLC3A2 SLC7A1 SLC7A11 SLC7A11 SLC7A11 SLC7A2 SLC7A5 SLCO2B1 SLFN2 SMAD7 SMCR8 SMCR8 SMOX SMOX SNX18 SOCS3 SPAG9 SPAG9 SPARCL1 SPHK1 SPHK1 SPRY2 SPTY2D1 SPTY2D1 SRGN SRXN1 SRXN1 SRXN1 ST3GAL1 ST6GALNAC4 ST6GALNAC4 STFA3 STK38L STX11 TES TGM2 TGM2 THAP2 THBS1 THBS1 THBS1 TMEM144 TMEM144 TMEM2 TMEM88 TMTC2 TNF TNFAIP3 TNFAIP6 TNFRSF12A TNFRSF9 TNFRSF9 TNFSF9 TPBG TPI1 TRAF1 TRAF5 TREM1 TREM1 TRIB3 TRIB3 TRIM25 TRIM69 TSPAN33 TTC39B TTC39B TUBB6 TXNRD1 UCK2 UCK2 UCP1 UNC13A UNC5B UQCRQ USP53 USP53 VASN VCAM1 VEGFA VEGFA VEGFA VEGFA VEGFA VEGFA ZBTB10 ZBTB7C ZC3H12A ZC3H12C ZC3HAV1L ZFAND5 ZFP131 ZFP36 ZFP36 ZFP36L1 ZFP36L1 ZFP558-PS ZFP655
Genes decreased by C. albicans in wild type resident mouse peritoneal macrophages

ABCD2 ABCG1 AHRR AKR1B10 ANGPTL4 APOBEC1 ARHGAP11A ARHGAP22 B3GNT8 BAHCC1 BC013712 BMF C85492 CALHM2 CASP2 CBX6 CCDC125 CD180 CD200R1 CD28 CEBPA CEP78 CHST14 DBT DENND2A DFNA5 DKK2 DNAJC28 DOCK8 EFCAB4A ENGASE ESPL1 ETAA1 EXOC3 FAM105A FAM110B FAM78A FGD4 FUT10 GAB3 GATC GPR155 GPR160 HMHA1 IDH1 IFIT3 IGF1 IIGP1 ITGA4 KCNJ10 KCTD12B LDLRAD3 LIPT2 LPCAT1 MAN2A2 MBLAC1 MBLAC2 MLH3 MRPL15 MS4A7 MXD4 MYO1F MZF1 NFAM1 NFIC NUAK1 OXA1L PCTP PGAP1 PGM2L1 PHLDA3 PILRB2 PLEKHG3 PPARGC1B PSTK PYGB RAB3A RIN2 RNF144B SEPHS2 SERPINB8 SESN1 SLC43A2 SNX27 STX17 TMEM18 TMEM86A TRIM21 TRMT12 TRP53INP1 TRUB1 TSEN2 TTC30A1 TTC30B TXNIP USP18 WBSCR27 WRB XRCC6BP1 YPEL2 ZBTB8A ZFP61 ZFP710 ZFP94 ZFYVE28 ZKSCAN4


 

 

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Last update: October 10, 2016

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