These maps, etched out by the host/pathogen T.Gondii interactome are generated by Kegg pathways from the Kanehisa laboratories with thanks and are subject to their copyright conditions: Genes are enhanced by CLICK on "SHOW ALL OBJECTS" TO SEE GENES Yellow represents host/pathogen interactions and red compounds or proteins are those used or donated by the pathogen.

Please cite: Toxoplasmosis and polygenic diseases: Extensive T.Gondii host/pathogen interactome enrichment in nine psychiatric or neurological disorders J.Pathogens, 2012

Pathway Search Result

Pathway Search Result

hsa01100 Metabolic pathways - Homo sapiens (human) (269) (No map available) 

cpd:C00002 ATP
cpd:C00018 Pyridoxal phosphate
cpd:C00031 D-Glucose
cpd:C00051 Glutathione
cpd:C00062 L-Arginine
cpd:C00064 L-Glutamine
cpd:C00065 L-Serine
cpd:C00077 L-Ornithine
cpd:C00078 L-Tryptophan
cpd:C00114 Choline
cpd:C00124 D-Galactose
cpd:C00134 Putrescine
cpd:C00147 Adenine
cpd:C00157 Phosphatidylcholine
cpd:C00159 D-Mannose
cpd:C00189 Ethanolamine
cpd:C00195 N-Acylsphingosine
cpd:C00212 Adenosine
cpd:C00214 Thymidine
cpd:C00219 Arachidonate
cpd:C00242 Guanine
cpd:C00243 Lactose
cpd:C00249 Hexadecanoic acid
cpd:C00262 Hypoxanthine
cpd:C00270 N-Acetylneuraminate
cpd:C00294 Inosine
cpd:C00299 Uridine
cpd:C00315 Spermidine
cpd:C00328 L-Kynurenine
cpd:C00338 Lipopolysaccharide
cpd:C00350 Phosphatidylethanolamine
cpd:C00355 3,4-Dihydroxy-L-phenylalanine
cpd:C00356 (S)-3-Hydroxy-3-methylglutaryl-CoA
cpd:C00385 Xanthine
cpd:C00387 Guanosine
cpd:C00475 Cytidine
cpd:C00504 Folate
cpd:C00535 Testosterone
cpd:C00547 L-Noradrenaline
cpd:C00584 Prostaglandin E2
cpd:C00725 Lipoate
cpd:C00750 Spermine
cpd:C00951 Estradiol-17beta
cpd:C01194 1-Phosphatidyl-D-myo-inositol
cpd:C01227 Dehydroepiandrosterone
cpd:C01598 Melatonin
cpd:C01673 Calcitriol
cpd:C01717 4-Hydroxy-2-quinolinecarboxylic acid
cpd:C01829 Thyroxine
cpd:C02165 Leukotriene B4
cpd:C02166 Leukotriene C4
cpd:C02477 alpha-Tocopherol
cpd:C02700 L-Formylkynurenine
cpd:C02737 Phosphatidylserine
cpd:C03758 Dopamine
cpd:C04598 2-Acetyl-1-alkyl-sn-glycero-3-phosphocholine
cpd:C05582 Homovanillate
cpd:C05951 Leukotriene D4
cpd:C05961 6-Keto-prostaglandin F1alpha
cpd:C05980 Cardiolipin
ec:5.3.3.12 L-dopachrome isomerase; dopachrome tautomerase; tyrosinase-related protein 2; TRP-1; TRP2; TRP-2; tyrosinase-related protein-2; dopachrome Delta7,Delta2-isomerase; dopachrome Delta-isomerase; dopachrome conversion factor; dopachrome isomerase; dopachrome oxidoreductase; dopachrome-rearranging enzyme; DCF; DCT; dopachrome keto-enol isomerase; L-dopachrome-methyl ester tautomerase
gl:G00063 IV3NeuAc,III3Fuc-nLc4Cer
hsa:33 ACADL; acyl-CoA dehydrogenase, long chain (EC:1.3.99.13)
hsa:37 ACADVL; acyl-CoA dehydrogenase, very long chain (EC:1.3.99.-)
hsa:38 ACAT1; acetyl-CoA acetyltransferase 1 (EC:2.3.1.9)
hsa:48 ACO1; aconitase 1, soluble (EC:4.2.1.3)
hsa:50 ACO2; aconitase 2, mitochondrial (EC:4.2.1.3)
hsa:51 ACOX1; acyl-CoA oxidase 1, palmitoyl (EC:1.3.3.6)
hsa:2180 ACSL1; acyl-CoA synthetase long-chain family member 1 (EC:6.2.1.3)
hsa:100 ADA; adenosine deaminase (EC:3.5.4.4)
hsa:132 ADK; adenosine kinase (EC:2.7.1.20)
hsa:84803 AGPAT9; 1-acylglycerol-3-phosphate O-acyltransferase 9 (EC:2.3.1.15)
hsa:204 AK2; adenylate kinase 2 (EC:2.7.4.3)
hsa:231 AKR1B1; aldo-keto reductase family 1, member B1 (aldose reductase) (EC:1.1.1.21)
hsa:8854 ALDH1A2; aldehyde dehydrogenase 1 family, member A2 (EC:1.2.1.36)
hsa:219 ALDH1B1; aldehyde dehydrogenase 1 family, member B1 (EC:1.2.1.3)
hsa:4329 ALDH6A1; aldehyde dehydrogenase 6 family, member A1 (EC:1.2.1.27 1.2.1.18)
hsa:501 ALDH7A1; aldehyde dehydrogenase 7 family, member A1 (EC:1.2.1.3 1.2.1.8 1.2.1.31)
hsa:223 ALDH9A1; aldehyde dehydrogenase 9 family, member A1 (EC:1.2.1.3 1.2.1.19 1.2.1.47)
hsa:226 ALDOA; aldolase A, fructose-bisphosphate (EC:4.1.2.13)
hsa:229 ALDOB; aldolase B, fructose-bisphosphate (EC:4.1.2.13)
hsa:56052 ALG1; asparagine-linked glycosylation 1, beta-1,4-mannosyltransferase homolog (S. cerevisiae) (EC:2.4.1.142)
hsa:239 ALOX12; arachidonate 12-lipoxygenase (EC:1.13.11.31)
hsa:246 ALOX15; arachidonate 15-lipoxygenase (EC:1.13.11.33)
hsa:240 ALOX5; arachidonate 5-lipoxygenase (EC:1.13.11.34)
hsa:270 AMPD1; adenosine monophosphate deaminase 1 (EC:3.5.4.6)
hsa:271 AMPD2; adenosine monophosphate deaminase 2 (EC:3.5.4.6)
hsa:272 AMPD3; adenosine monophosphate deaminase 3 (EC:3.5.4.6)
hsa:279 AMY2A; amylase, alpha 2A (pancreatic) (EC:3.2.1.1)
hsa:353 APRT; adenine phosphoribosyltransferase (EC:2.4.2.7)
hsa:383 ARG1; arginase, liver (EC:3.5.3.1)
hsa:384 ARG2; arginase, type II (EC:3.5.3.1)
hsa:411 ARSB; arylsulfatase B (EC:3.1.6.12)
hsa:445 ASS1; argininosuccinate synthase 1 (EC:6.3.4.5)
hsa:498 ATP5A1; ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle
hsa:513 ATP5D; ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit (EC:3.6.1.14)
hsa:516 ATP5G1; ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)
hsa:4508 ATP6; ATP synthase F0 subunit 6
hsa:535 ATP6V0A1; ATPase, H+ transporting, lysosomal V0 subunit a1 (EC:3.6.3.14)
hsa:533 ATP6V0B; ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b (EC:3.6.3.14)
hsa:245972 ATP6V0D2; ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2 (EC:3.6.3.14)
hsa:523 ATP6V1A; ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A (EC:3.6.3.14)
hsa:2583 B4GALNT1; beta-1,4-N-acetyl-galactosaminyl transferase 1 (EC:2.4.1.92)
hsa:683 BST1; bone marrow stromal cell antigen 1 (EC:3.2.2.5)
hsa:847 CAT; catalase (EC:1.11.1.6)
hsa:873 CBR1; carbonyl reductase 1 (EC:1.1.1.189 1.1.1.197 1.1.1.184)
hsa:883 CCBL1; cysteine conjugate-beta lyase, cytoplasmic (EC:2.6.1.64 2.6.1.7 4.4.1.13)
hsa:952 CD38; CD38 molecule (EC:3.2.2.5)
hsa:55748 CNDP2; CNDP dipeptidase 2 (metallopeptidase M20 family) (EC:3.4.13.18)
hsa:80347 COASY; CoA synthase (EC:2.7.7.3 2.7.1.24)
hsa:4514 COX3; cytochrome c oxidase III
hsa:1350 COX7C; cytochrome c oxidase subunit VIIc (EC:1.9.3.1)
hsa:1371 CPOX; coproporphyrinogen oxidase (EC:1.3.3.3)
hsa:1431 CS; citrate synthase (EC:2.3.3.1)
hsa:51380 CSAD; cysteine sulfinic acid decarboxylase (EC:4.1.1.29)
hsa:120227 CYP2R1; cytochrome P450, family 2, subfamily R, polypeptide 1 (EC:1.14.13.15)
hsa:4519 CYTB; cytochrome b
hsa:1603 DAD1; defender against cell death 1 (EC:2.4.1.119)
hsa:26007 DAK; dihydroxyacetone kinase 2 homolog (S. cerevisiae) (EC:2.7.1.29 4.6.1.15)
hsa:1633 DCK; deoxycytidine kinase (EC:2.7.1.74)
hsa:1638 DCT; dopachrome tautomerase (dopachrome delta-isomerase, tyrosine-related protein 2) (EC:5.3.3.12)
hsa:1635 DCTD; dCMP deaminase (EC:3.5.4.12)
hsa:1644 DDC; dopa decarboxylase (aromatic L-amino acid decarboxylase) (EC:4.1.1.28)
hsa:8525 DGKZ; diacylglycerol kinase, zeta (EC:2.7.1.107)
hsa:1716 DGUOK; deoxyguanosine kinase (EC:2.7.1.113)
hsa:9249 DHRS3; dehydrogenase/reductase (SDR family) member 3 (EC:1.1.1.300)
hsa:1788 DNMT3A; DNA (cytosine-5-)-methyltransferase 3 alpha (EC:2.1.1.37)
hsa:1789 DNMT3B; DNA (cytosine-5-)-methyltransferase 3 beta (EC:2.1.1.37)
hsa:8813 DPM1; dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit (EC:2.4.1.83)
hsa:1806 DPYD; dihydropyrimidine dehydrogenase (EC:1.3.1.2)
hsa:1892 ECHS1; enoyl CoA hydratase, short chain, 1, mitochondrial (EC:4.2.1.17)
hsa:2023 ENO1; enolase 1, (alpha) (EC:4.2.1.11)
hsa:5167 ENPP1; ectonucleotide pyrophosphatase/phosphodiesterase 1 (EC:3.1.4.1 3.6.1.9)
hsa:2184 FAH; fumarylacetoacetate hydrolase (fumarylacetoacetase) (EC:3.7.1.2)
hsa:2222 FDFT1; farnesyl-diphosphate farnesyltransferase 1 (EC:2.5.1.21)
hsa:2224 FDPS; farnesyl diphosphate synthase (EC:2.5.1.1 2.5.1.10)
hsa:8790 FPGT; fucose-1-phosphate guanylyltransferase (EC:2.7.7.30)
hsa:2538 G6PC; glucose-6-phosphatase, catalytic subunit (EC:3.1.3.9)
hsa:2591 GALNT3; UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3) (EC:2.4.1.41)
hsa:11226 GALNT6; UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 6 (GalNAc-T6) (EC:2.4.1.41)
hsa:2592 GALT; galactose-1-phosphate uridylyltransferase (EC:2.7.7.12)
hsa:2593 GAMT; guanidinoacetate N-methyltransferase (EC:2.1.1.2)
hsa:2597 GAPDH; glyceraldehyde-3-phosphate dehydrogenase (EC:1.2.1.12)
hsa:2643 GCH1; GTP cyclohydrolase 1 (EC:3.5.4.16)
hsa:2729 GCLC; glutamate-cysteine ligase, catalytic subunit (EC:6.3.2.2)
hsa:2730 GCLM; glutamate-cysteine ligase, modifier subunit (EC:6.3.2.2)
hsa:51301 GCNT4; glucosaminyl (N-acetyl) transferase 4, core 2 (EC:2.4.1.102)
hsa:2673 GFPT1; glutamine--fructose-6-phosphate transaminase 1 (EC:2.6.1.16)
hsa:2710 GK; glycerol kinase (EC:2.7.1.30)
hsa:2744 GLS; glutaminase (EC:3.5.1.2)
hsa:27165 GLS2; glutaminase 2 (liver, mitochondrial) (EC:3.5.1.2)
hsa:2752 GLUL; glutamate-ammonia ligase (EC:4.1.1.15 6.3.1.2)
hsa:10020 GNE; glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase (EC:5.1.3.14 2.7.1.60)
hsa:2821 GPI; glucose-6-phosphate isomerase (EC:5.3.1.9)
hsa:2937 GSS; glutathione synthetase (EC:6.3.2.3)
hsa:2990 GUSB; glucuronidase, beta (EC:3.2.1.31)
hsa:3030 HADHA; hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit (EC:4.2.1.17 1.1.1.211)
hsa:3074 HEXB; hexosaminidase B (beta polypeptide) (EC:3.2.1.52)
hsa:3098 HK1; hexokinase 1 (EC:2.7.1.1)
hsa:3099 HK2; hexokinase 2 (EC:2.7.1.1)
hsa:3101 HK3; hexokinase 3 (white cell) (EC:2.7.1.1)
hsa:3156 HMGCR; 3-hydroxy-3-methylglutaryl-CoA reductase (EC:1.1.1.34)
hsa:3157 HMGCS1; 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) (EC:2.3.3.10)
hsa:3158 HMGCS2; 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) (EC:2.3.3.10)
hsa:3251 HPRT1; hypoxanthine phosphoribosyltransferase 1 (EC:2.4.2.8)
hsa:10855 HPSE; heparanase
hsa:3028 HSD17B10; hydroxysteroid (17-beta) dehydrogenase 10 (EC:1.1.1.35 1.1.1.178)
hsa:3294 HSD17B2; hydroxysteroid (17-beta) dehydrogenase 2 (EC:1.1.1.62 1.1.1.63)
hsa:8630 HSD17B6; hydroxysteroid (17-beta) dehydrogenase 6 homolog (mouse) (EC:1.1.1.62 1.1.1.63 1.1.1.105)
hsa:3417 IDH1; isocitrate dehydrogenase 1 (NADP+), soluble (EC:1.1.1.42)
hsa:3418 IDH2; isocitrate dehydrogenase 2 (NADP+), mitochondrial (EC:1.1.1.42)
hsa:3421 IDH3G; isocitrate dehydrogenase 3 (NAD+) gamma (EC:1.1.1.41)
hsa:3620 IDO1; indoleamine 2,3-dioxygenase 1 (EC:1.13.11.52)
hsa:3613 IMPA2; inositol(myo)-1(or 4)-monophosphatase 2 (EC:3.1.3.25)
hsa:3633 INPP5B; inositol polyphosphate-5-phosphatase, 75kDa (EC:3.1.3.36)
hsa:27124 INPP5J; inositol polyphosphate-5-phosphatase J (EC:3.1.3.56)
hsa:3706 ITPKA; inositol-trisphosphate 3-kinase A (EC:2.7.1.127)
hsa:8942 KYNU; kynureninase (EC:3.7.1.3)
hsa:51056 LAP3; leucine aminopeptidase 3 (EC:3.4.11.5 3.4.11.1)
hsa:3939 LDHA; lactate dehydrogenase A (EC:1.1.1.27)
hsa:79888 LPCAT1; lysophosphatidylcholine acyltransferase 1 (EC:2.3.1.23 2.3.1.67)
hsa:254531 LPCAT4; lysophosphatidylcholine acyltransferase 4 (EC:2.3.1.51)
hsa:23175 LPIN1; lipin 1 (EC:3.1.3.4)
hsa:9663 LPIN2; lipin 2 (EC:3.1.3.4)
hsa:4048 LTA4H; leukotriene A4 hydrolase (EC:3.3.2.6)
hsa:4122 MAN2A2; mannosidase, alpha, class 2A, member 2 (EC:3.2.1.114)
hsa:4128 MAOA; monoamine oxidase A (EC:1.4.3.4)
hsa:4190 MDH1; malate dehydrogenase 1, NAD (soluble) (EC:1.1.1.37)
hsa:11343 MGLL; monoglyceride lipase (EC:3.1.1.23)
hsa:4507 MTAP; methylthioadenosine phosphorylase (EC:2.4.2.28)
hsa:4522 MTHFD1; methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase (EC:1.5.1.5 6.3.4.3 3.5.4.9)
hsa:25902 MTHFD1L; methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like (EC:6.3.4.3)
hsa:10797 MTHFD2; methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase (EC:3.5.4.9 1.5.1.15)
hsa:4597 MVD; mevalonate (diphospho) decarboxylase (EC:4.1.1.33)
hsa:93100 NAPRT1; nicotinate phosphoribosyltransferase domain containing 1 (EC:2.4.2.11)
hsa:4535 ND1; NADH dehydrogenase, subunit 1 (complex I)
hsa:4538 ND4; NADH dehydrogenase, subunit 4 (complex I)
hsa:3340 NDST1; N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 (EC:2.8.2.8)
hsa:4725 NDUFS5; NADH dehydrogenase (ubiquinone) Fe-S protein 5, 15kDa (NADH-coenzyme Q reductase)
hsa:374291 NDUFS7; NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase) (EC:1.6.5.3 1.6.99.3)
hsa:4731 NDUFV3; NADH dehydrogenase (ubiquinone) flavoprotein 3, 10kDa (EC:1.6.5.3)
hsa:4830 NME1; non-metastatic cells 1, protein (NM23A) expressed in (EC:2.7.4.6)
hsa:4831 NME2; non-metastatic cells 2, protein (NM23B) expressed in (EC:2.7.4.6 2.7.13.3)
hsa:4833 NME4; non-metastatic cells 4, protein expressed in (EC:2.7.4.6)
hsa:10201 NME6; non-metastatic cells 6, protein expressed in (nucleoside-diphosphate kinase) (EC:2.7.4.6)
hsa:4842 NOS1; nitric oxide synthase 1 (neuronal) (EC:1.14.13.39)
hsa:4843 NOS2; nitric oxide synthase 2, inducible (EC:1.14.13.39)
hsa:93034 NT5C1B; 5'-nucleotidase, cytosolic IB (EC:3.1.3.5)
hsa:4907 NT5E; 5'-nucleotidase, ecto (CD73) (EC:3.1.3.5)
hsa:5009 OTC; ornithine carbamoyltransferase (EC:2.1.3.3)
hsa:5048 PAFAH1B1; platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) (EC:3.1.1.47)
hsa:5096 PCCB; propionyl CoA carboxylase, beta polypeptide (EC:6.4.1.3)
hsa:5105 PCK1; phosphoenolpyruvate carboxykinase 1 (soluble) (EC:4.1.1.32)
hsa:5198 PFAS; phosphoribosylformylglycinamidine synthase (EC:6.3.5.3)
hsa:5211 PFKL; phosphofructokinase, liver (EC:2.7.1.11)
hsa:5214 PFKP; phosphofructokinase, platelet (EC:2.7.1.11)
hsa:5223 PGAM1; phosphoglycerate mutase 1 (brain) (EC:3.1.3.13 5.4.2.1 5.4.2.4)
hsa:5224 PGAM2; phosphoglycerate mutase 2 (muscle) (EC:3.1.3.13 5.4.2.1 5.4.2.4)
hsa:5230 PGK1; phosphoglycerate kinase 1 (EC:2.7.2.3)
hsa:25796 PGLS; 6-phosphogluconolactonase (EC:3.1.1.31)
hsa:55276 PGM2; phosphoglucomutase 2 (EC:5.4.2.2 5.4.2.7)
hsa:9489 PGS1; phosphatidylglycerophosphate synthase 1 (EC:2.7.8.5)
hsa:26227 PHGDH; phosphoglycerate dehydrogenase (EC:1.1.1.95)
hsa:84720 PIGO; phosphatidylinositol glycan anchor biosynthesis, class O
hsa:5289 PIK3C3; phosphoinositide-3-kinase, class 3 (EC:2.7.1.137)
hsa:5315 PKM2; pyruvate kinase, muscle (EC:2.7.1.40)
hsa:5321 PLA2G4A; phospholipase A2, group IVA (cytosolic, calcium-dependent) (EC:3.1.1.5 3.1.1.4)
hsa:5330 PLCB2; phospholipase C, beta 2 (EC:3.1.4.11)
hsa:5331 PLCB3; phospholipase C, beta 3 (phosphatidylinositol-specific) (EC:3.1.4.11)
hsa:5335 PLCG1; phospholipase C, gamma 1 (EC:3.1.4.11)
hsa:5337 PLD1; phospholipase D1, phosphatidylcholine-specific (EC:3.1.4.4)
hsa:4860 PNP; purine nucleoside phosphorylase (EC:2.4.2.1)
hsa:55163 PNPO; pyridoxamine 5'-phosphate oxidase (EC:1.4.3.5)
hsa:54107 POLE3; polymerase (DNA directed), epsilon 3 (p17 subunit) (EC:2.7.7.7)
hsa:25885 POLR1A; polymerase (RNA) I polypeptide A, 194kDa (EC:2.7.7.6)
hsa:84172 POLR1B; polymerase (RNA) I polypeptide B, 128kDa (EC:2.7.7.6)
hsa:9533 POLR1C; polymerase (RNA) I polypeptide C, 30kDa
hsa:51082 POLR1D; polymerase (RNA) I polypeptide D, 16kDa
hsa:64425 POLR1E; polymerase (RNA) I polypeptide E, 53kDa
hsa:51728 POLR3K; polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
hsa:5471 PPAT; phosphoribosyl pyrophosphate amidotransferase (EC:2.4.2.14)
hsa:5538 PPT1; palmitoyl-protein thioesterase 1 (EC:3.1.2.22)
hsa:9588 PRDX6; peroxiredoxin 6 (EC:1.11.1.9 1.11.1.15)
hsa:5557 PRIM1; primase, DNA, polypeptide 1 (49kDa) (EC:2.7.7.-)
hsa:9791 PTDSS1; phosphatidylserine synthase 1
hsa:9536 PTGES; prostaglandin E synthase (EC:5.3.99.3)
hsa:5743 PTGS2; prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1)
hsa:50700 RDH8; retinol dehydrogenase 8 (all-trans) (EC:1.1.1.300)
hsa:50484 RRM2B; ribonucleotide reductase M2 B (TP53 inducible) (EC:1.17.4.1)
hsa:8879 SGPL1; sphingosine-1-phosphate lyase 1 (EC:4.1.2.27)
hsa:6470 SHMT1; serine hydroxymethyltransferase 1 (soluble) (EC:2.1.2.1)
hsa:55512 SMPD3; sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II) (EC:3.1.4.12)
hsa:6713 SQLE; squalene epoxidase (EC:1.14.13.132)
hsa:6723 SRM; spermidine synthase (EC:2.5.1.16)
hsa:6480 ST6GAL1; ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 (EC:2.4.99.1)
hsa:8802 SUCLG1; succinate-CoA ligase, alpha subunit (EC:6.2.1.4 6.2.1.5)
hsa:6916 TBXAS1; thromboxane A synthase 1 (platelet) (EC:5.3.99.5)
hsa:6999 TDO2; tryptophan 2,3-dioxygenase (EC:1.13.11.11)
hsa:7054 TH; tyrosine hydroxylase (EC:1.14.16.2)
hsa:7083 TK1; thymidine kinase 1, soluble (EC:2.7.1.21)
hsa:7108 TM7SF2; transmembrane 7 superfamily member 2 (EC:1.3.1.70)
hsa:7167 TPI1; triosephosphate isomerase 1 (EC:5.3.1.1)
hsa:221830 TWISTNB; TWIST neighbor
hsa:1890 TYMP; thymidine phosphorylase (EC:2.4.2.4)
hsa:7298 TYMS; thymidylate synthetase (EC:2.1.1.45)
hsa:7372 UMPS; uridine monophosphate synthetase (EC:2.4.2.10 4.1.1.23)
hsa:7378 UPP1; uridine phosphorylase 1 (EC:2.4.2.3)
hsa:7498 XDH; xanthine dehydrogenase (EC:1.17.1.4 1.17.3.2)
hsa:64132 XYLT2; xylosyltransferase II (EC:2.4.2.26)

hsa04060 Cytokine-cytokine receptor interaction - Homo sapiens (human) (103)



hsa:650 BMP2; bone morphogenetic protein 2
hsa:6346 CCL1; chemokine (C-C motif) ligand 1
hsa:6356 CCL11; chemokine (C-C motif) ligand 11
hsa:6358 CCL14; chemokine (C-C motif) ligand 14
hsa:6361 CCL17; chemokine (C-C motif) ligand 17
hsa:6347 CCL2; chemokine (C-C motif) ligand 2
hsa:6364 CCL20; chemokine (C-C motif) ligand 20
hsa:6348 CCL3; chemokine (C-C motif) ligand 3
hsa:6351 CCL4; chemokine (C-C motif) ligand 4
hsa:6352 CCL5; chemokine (C-C motif) ligand 5
hsa:6354 CCL7; chemokine (C-C motif) ligand 7
hsa:6355 CCL8; chemokine (C-C motif) ligand 8
hsa:1230 CCR1; chemokine (C-C motif) receptor 1
hsa:729230 CCR2; chemokine (C-C motif) receptor 2
hsa:1232 CCR3; chemokine (C-C motif) receptor 3
hsa:1233 CCR4; chemokine (C-C motif) receptor 4
hsa:1234 CCR5; chemokine (C-C motif) receptor 5 (gene/pseudogene)
hsa:1235 CCR6; chemokine (C-C motif) receptor 6
hsa:1236 CCR7; chemokine (C-C motif) receptor 7
hsa:10803 CCR9; chemokine (C-C motif) receptor 9
hsa:958 CD40; CD40 molecule, TNF receptor superfamily member 5
hsa:959 CD40LG; CD40 ligand
hsa:1270 CNTF; ciliary neurotrophic factor
hsa:1435 CSF1; colony stimulating factor 1 (macrophage) (EC:2.7.10.1)
hsa:1437 CSF2; colony stimulating factor 2 (granulocyte-macrophage)
hsa:1439 CSF2RB; colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
hsa:1440 CSF3; colony stimulating factor 3 (granulocyte)
hsa:1489 CTF1; cardiotrophin 1
hsa:1524 CX3CR1; chemokine (C-X3-C motif) receptor 1
hsa:2919 CXCL1; chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
hsa:3627 CXCL10; chemokine (C-X-C motif) ligand 10
hsa:6373 CXCL11; chemokine (C-X-C motif) ligand 11
hsa:6387 CXCL12; chemokine (C-X-C motif) ligand 12
hsa:2920 CXCL2; chemokine (C-X-C motif) ligand 2
hsa:2921 CXCL3; chemokine (C-X-C motif) ligand 3
hsa:6374 CXCL5; chemokine (C-X-C motif) ligand 5
hsa:4283 CXCL9; chemokine (C-X-C motif) ligand 9
hsa:3579 CXCR2; chemokine (C-X-C motif) receptor 2
hsa:7852 CXCR4; chemokine (C-X-C motif) receptor 4
hsa:643 CXCR5; chemokine (C-X-C motif) receptor 5
hsa:355 FAS; Fas (TNF receptor superfamily, member 6)
hsa:2321 FLT1; fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) (EC:2.7.10.1)
hsa:3439 IFNA1; interferon, alpha 1
hsa:3443 IFNA6; interferon, alpha 6
hsa:3458 IFNG; interferon, gamma
hsa:3459 IFNGR1; interferon gamma receptor 1
hsa:3460 IFNGR2; interferon gamma receptor 2 (interferon gamma transducer 1)
hsa:3586 IL10; interleukin 10
hsa:3587 IL10RA; interleukin 10 receptor, alpha
hsa:3588 IL10RB; interleukin 10 receptor, beta
hsa:3589 IL11; interleukin 11
hsa:3590 IL11RA; interleukin 11 receptor, alpha
hsa:3592 IL12A; interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)
hsa:3593 IL12B; interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)
hsa:3595 IL12RB2; interleukin 12 receptor, beta 2
hsa:3596 IL13; interleukin 13
hsa:3600 IL15; interleukin 15
hsa:3601 IL15RA; interleukin 15 receptor, alpha
hsa:3605 IL17A; interleukin 17A
hsa:23765 IL17RA; interleukin 17 receptor A
hsa:3606 IL18; interleukin 18 (interferon-gamma-inducing factor)
hsa:8809 IL18R1; interleukin 18 receptor 1
hsa:3552 IL1A; interleukin 1, alpha
hsa:3553 IL1B; interleukin 1, beta
hsa:3558 IL2; interleukin 2
hsa:50616 IL22; interleukin 22
hsa:3559 IL2RA; interleukin 2 receptor, alpha
hsa:3560 IL2RB; interleukin 2 receptor, beta
hsa:3561 IL2RG; interleukin 2 receptor, gamma
hsa:3562 IL3; interleukin 3 (colony-stimulating factor, multiple)
hsa:3563 IL3RA; interleukin 3 receptor, alpha (low affinity)
hsa:3565 IL4; interleukin 4
hsa:3566 IL4R; interleukin 4 receptor
hsa:3567 IL5; interleukin 5 (colony-stimulating factor, eosinophil)
hsa:3569 IL6; interleukin 6 (interferon, beta 2)
hsa:3572 IL6ST; interleukin 6 signal transducer (gp130, oncostatin M receptor)
hsa:3574 IL7; interleukin 7
hsa:3575 IL7R; interleukin 7 receptor
hsa:3576 IL8; interleukin 8
hsa:3624 INHBA; inhibin, beta A
hsa:4254 KITLG; KIT ligand
hsa:3976 LIF; leukemia inhibitory factor
hsa:4049 LTA; lymphotoxin alpha (TNF superfamily, member 1)
hsa:4050 LTB; lymphotoxin beta (TNF superfamily, member 3)
hsa:5008 OSM; oncostatin M
hsa:5154 PDGFA; platelet-derived growth factor alpha polypeptide
hsa:5155 PDGFB; platelet-derived growth factor beta polypeptide
hsa:5196 PF4; platelet factor 4
hsa:5473 PPBP; pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
hsa:5617 PRL; prolactin
hsa:7040 TGFB1; transforming growth factor, beta 1
hsa:7046 TGFBR1; transforming growth factor, beta receptor 1 (EC:2.7.11.30)
hsa:7124 TNF; tumor necrosis factor
hsa:8792 TNFRSF11A; tumor necrosis factor receptor superfamily, member 11a, NFKB activator
hsa:51330 TNFRSF12A; tumor necrosis factor receptor superfamily, member 12A
hsa:8764 TNFRSF14; tumor necrosis factor receptor superfamily, member 14
hsa:7132 TNFRSF1A; tumor necrosis factor receptor superfamily, member 1A
hsa:7133 TNFRSF1B; tumor necrosis factor receptor superfamily, member 1B
hsa:7293 TNFRSF4; tumor necrosis factor receptor superfamily, member 4
hsa:3604 TNFRSF9; tumor necrosis factor receptor superfamily, member 9
hsa:8743 TNFSF10; tumor necrosis factor (ligand) superfamily, member 10
hsa:7292 TNFSF4; tumor necrosis factor (ligand) superfamily, member 4
hsa:85480 TSLP; thymic stromal lymphopoietin

hsa05200 Pathways in cancer - Homo sapiens (human) (94)



cpd:C00165 Diacylglycerol
cpd:C00535 Testosterone
cpd:C00951 Estradiol-17beta
cpd:C01227 Dehydroepiandrosterone
hsa:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1)
hsa:8313 AXIN2; axin 2
hsa:572 BAD; BCL2-associated agonist of cell death
hsa:581 BAX; BCL2-associated X protein
hsa:596 BCL2; B-cell CLL/lymphoma 2
hsa:637 BID; BH3 interacting domain death agonist
hsa:329 BIRC2; baculoviral IAP repeat containing 2
hsa:330 BIRC3; baculoviral IAP repeat containing 3
hsa:650 BMP2; bone morphogenetic protein 2
hsa:836 CASP3; caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56)
hsa:841 CASP8; caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61)
hsa:842 CASP9; caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62)
hsa:8030 CCDC6; coiled-coil domain containing 6
hsa:595 CCND1; cyclin D1
hsa:1017 CDK2; cyclin-dependent kinase 2 (EC:2.7.11.22)
hsa:1026 CDKN1A; cyclin-dependent kinase inhibitor 1A (p21, Cip1)
hsa:1027 CDKN1B; cyclin-dependent kinase inhibitor 1B (p27, Kip1)
hsa:1050 CEBPA; CCAAT/enhancer binding protein (C/EBP), alpha
hsa:1147 CHUK; conserved helix-loop-helix ubiquitous kinase (EC:2.7.11.10)
hsa:1287 COL4A5; collagen, type IV, alpha 5
hsa:1488 CTBP2; C-terminal binding protein 2
hsa:54205 CYCS; cytochrome c, somatic
hsa:2034 EPAS1; endothelial PAS domain protein 1
hsa:2064 ERBB2; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) (EC:2.7.10.1)
hsa:2113 ETS1; v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)
hsa:8772 FADD; Fas (TNFRSF6)-associated via death domain
hsa:355 FAS; Fas (TNF receptor superfamily, member 6)
hsa:2258 FGF13; fibroblast growth factor 13
hsa:2252 FGF7; fibroblast growth factor 7
hsa:2335 FN1; fibronectin 1
hsa:2353 FOS; FBJ murine osteosarcoma viral oncogene homolog
hsa:8322 FZD4; frizzled family receptor 4
hsa:8324 FZD7; frizzled family receptor 7
hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26)
hsa:64399 HHIP; hedgehog interacting protein
hsa:3091 HIF1A; hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
hsa:3326 HSP90AB1; heat shock protein 90kDa alpha (cytosolic), class B member 1
hsa:7184 HSP90B1; heat shock protein 90kDa beta (Grp94), member 1
hsa:3479 IGF1; insulin-like growth factor 1 (somatomedin C)
hsa:3569 IL6; interleukin 6 (interferon, beta 2)
hsa:3576 IL8; interleukin 8
hsa:3673 ITGA2; integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
hsa:3655 ITGA6; integrin, alpha 6
hsa:3688 ITGB1; integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
hsa:3716 JAK1; Janus kinase 1 (EC:2.7.10.2)
hsa:3725 JUN; jun proto-oncogene
hsa:3728 JUP; junction plakoglobin
hsa:4254 KITLG; KIT ligand
hsa:3910 LAMA4; laminin, alpha 4
hsa:3914 LAMB3; laminin, beta 3
hsa:5605 MAP2K2; mitogen-activated protein kinase kinase 2 (EC:2.7.12.2)
hsa:5594 MAPK1; mitogen-activated protein kinase 1 (EC:2.7.11.24)
hsa:5595 MAPK3; mitogen-activated protein kinase 3 (EC:2.7.11.24)
hsa:5601 MAPK9; mitogen-activated protein kinase 9 (EC:2.7.11.24)
hsa:4149 MAX; MYC associated factor X
hsa:4312 MMP1; matrix metallopeptidase 1 (interstitial collagenase) (EC:3.4.24.7)
hsa:4313 MMP2; matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24)
hsa:4318 MMP9; matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35)
hsa:2475 MTOR; mechanistic target of rapamycin (serine/threonine kinase) (EC:2.7.11.1)
hsa:4609 MYC; v-myc myelocytomatosis viral oncogene homolog (avian)
hsa:8031 NCOA4; nuclear receptor coactivator 4
hsa:4790 NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
hsa:4791 NFKB2; nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
hsa:4792 NFKBIA; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
hsa:4843 NOS2; nitric oxide synthase 2, inducible (EC:1.14.13.39)
hsa:5154 PDGFA; platelet-derived growth factor alpha polypeptide
hsa:5155 PDGFB; platelet-derived growth factor beta polypeptide
hsa:5228 PGF; placental growth factor
hsa:9063 PIAS2; protein inhibitor of activated STAT, 2
hsa:5290 PIK3CA; phosphoinositide-3-kinase, catalytic, alpha polypeptide (EC:2.7.11.1 2.7.1.153)
hsa:5291 PIK3CB; phosphoinositide-3-kinase, catalytic, beta polypeptide (EC:2.7.1.153)
hsa:5294 PIK3CG; phosphoinositide-3-kinase, catalytic, gamma polypeptide (EC:2.7.11.1 2.7.1.153)
hsa:5335 PLCG1; phospholipase C, gamma 1 (EC:3.1.4.11)
hsa:5337 PLD1; phospholipase D1, phosphatidylcholine-specific (EC:3.1.4.4)
hsa:5371 PML; promyelocytic leukemia
hsa:5467 PPARD; peroxisome proliferator-activated receptor delta
hsa:5468 PPARG; peroxisome proliferator-activated receptor gamma
hsa:5578 PRKCA; protein kinase C, alpha (EC:2.7.11.13)
hsa:5579 PRKCB; protein kinase C, beta (EC:2.7.11.13)
hsa:5743 PTGS2; prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1)
hsa:5970 RELA; v-rel reticuloendotheliosis viral oncogene homolog A (avian)
hsa:4087 SMAD2; SMAD family member 2
hsa:6772 STAT1; signal transducer and activator of transcription 1, 91kDa
hsa:6934 TCF7L2; transcription factor 7-like 2 (T-cell specific, HMG-box)
hsa:7040 TGFB1; transforming growth factor, beta 1
hsa:7046 TGFBR1; transforming growth factor, beta receptor 1 (EC:2.7.11.30)
hsa:7170 TPM3; tropomyosin 3
hsa:7185 TRAF1; TNF receptor-associated factor 1
hsa:7189 TRAF6; TNF receptor-associated factor 6, E3 ubiquitin protein ligase
hsa:7474 WNT5A; wingless-type MMTV integration site family, member 5A

hsa05166 HTLV-I infection - Homo sapiens (human) (85)



cpd:C00027 Hydrogen peroxide
cpd:C00238 Potassium cation
cpd:C00575 3',5'-Cyclic AMP
hsa:109 ADCY3; adenylate cyclase 3 (EC:4.6.1.1)
hsa:112 ADCY6; adenylate cyclase 6 (EC:4.6.1.1)
hsa:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1)
hsa:467 ATF3; activating transcription factor 3
hsa:472 ATM; ataxia telangiectasia mutated (EC:2.7.11.1)
hsa:581 BAX; BCL2-associated X protein
hsa:329 BIRC2; baculoviral IAP repeat containing 2
hsa:330 BIRC3; baculoviral IAP repeat containing 3
hsa:811 CALR; calreticulin
hsa:821 CANX; calnexin
hsa:595 CCND1; cyclin D1
hsa:958 CD40; CD40 molecule, TNF receptor superfamily member 5
hsa:1026 CDKN1A; cyclin-dependent kinase inhibitor 1A (p21, Cip1)
hsa:1147 CHUK; conserved helix-loop-helix ubiquitous kinase (EC:2.7.11.10)
hsa:1385 CREB1; cAMP responsive element binding protein 1
hsa:200186 CRTC2; CREB regulated transcription coactivator 2
hsa:1437 CSF2; colony stimulating factor 2 (granulocyte-macrophage)
hsa:1958 EGR1; early growth response 1
hsa:1959 EGR2; early growth response 2
hsa:2113 ETS1; v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)
hsa:2224 FDPS; farnesyl diphosphate synthase (EC:2.5.1.1 2.5.1.10)
hsa:2353 FOS; FBJ murine osteosarcoma viral oncogene homolog
hsa:8322 FZD4; frizzled family receptor 4
hsa:8324 FZD7; frizzled family receptor 7
hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26)
hsa:3105 HLA-A; major histocompatibility complex, class I, A
hsa:3107 HLA-C; major histocompatibility complex, class I, C
hsa:3109 HLA-DMB; major histocompatibility complex, class II, DM beta
hsa:3118 HLA-DQA2; major histocompatibility complex, class II, DQ alpha 2
hsa:3134 HLA-F; major histocompatibility complex, class I, F
hsa:3135 HLA-G; major histocompatibility complex, class I, G
hsa:3383 ICAM1; intercellular adhesion molecule 1
hsa:3600 IL15; interleukin 15
hsa:3601 IL15RA; interleukin 15 receptor, alpha
hsa:3558 IL2; interleukin 2
hsa:3559 IL2RA; interleukin 2 receptor, alpha
hsa:3560 IL2RB; interleukin 2 receptor, beta
hsa:3561 IL2RG; interleukin 2 receptor, gamma
hsa:3569 IL6; interleukin 6 (interferon, beta 2)
hsa:3683 ITGAL; integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
hsa:3689 ITGB2; integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
hsa:3716 JAK1; Janus kinase 1 (EC:2.7.10.2)
hsa:3718 JAK3; Janus kinase 3 (EC:2.7.10.2)
hsa:3725 JUN; jun proto-oncogene
hsa:3932 LCK; lymphocyte-specific protein tyrosine kinase (EC:2.7.10.2)
hsa:4049 LTA; lymphotoxin alpha (TNF superfamily, member 1)
hsa:6416 MAP2K4; mitogen-activated protein kinase kinase 4 (EC:2.7.12.2)
hsa:9020 MAP3K14; mitogen-activated protein kinase kinase kinase 14 (EC:2.7.11.25)
hsa:5601 MAPK9; mitogen-activated protein kinase 9 (EC:2.7.11.24)
hsa:4488 MSX2; msh homeobox 2
hsa:4609 MYC; v-myc myelocytomatosis viral oncogene homolog (avian)
hsa:4772 NFATC1; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
hsa:4790 NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
hsa:4791 NFKB2; nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
hsa:4792 NFKBIA; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
hsa:5111 PCNA; proliferating cell nuclear antigen
hsa:5154 PDGFA; platelet-derived growth factor alpha polypeptide
hsa:5155 PDGFB; platelet-derived growth factor beta polypeptide
hsa:5290 PIK3CA; phosphoinositide-3-kinase, catalytic, alpha polypeptide (EC:2.7.11.1 2.7.1.153)
hsa:5291 PIK3CB; phosphoinositide-3-kinase, catalytic, beta polypeptide (EC:2.7.1.153)
hsa:5294 PIK3CG; phosphoinositide-3-kinase, catalytic, gamma polypeptide (EC:2.7.11.1 2.7.1.153)
hsa:5423 POLB; polymerase (DNA directed), beta (EC:2.7.7.7)
hsa:54107 POLE3; polymerase (DNA directed), epsilon 3 (p17 subunit) (EC:2.7.7.7)
hsa:5530 PPP3CA; protein phosphatase 3, catalytic subunit, alpha isozyme (EC:3.1.3.16)
hsa:5532 PPP3CB; protein phosphatase 3, catalytic subunit, beta isozyme (EC:3.1.3.16)
hsa:5533 PPP3CC; protein phosphatase 3, catalytic subunit, gamma isozyme (EC:3.1.3.16)
hsa:5902 RANBP1; RAN binding protein 1
hsa:5970 RELA; v-rel reticuloendotheliosis viral oncogene homolog A (avian)
hsa:5971 RELB; v-rel reticuloendotheliosis viral oncogene homolog B
hsa:6237 RRAS; related RAS viral (r-ras) oncogene homolog
hsa:4087 SMAD2; SMAD family member 2
hsa:6722 SRF; serum response factor (c-fos serum response element-binding transcription factor)
hsa:9519 TBPL1; TBP-like 1
hsa:7040 TGFB1; transforming growth factor, beta 1
hsa:7046 TGFBR1; transforming growth factor, beta receptor 1 (EC:2.7.11.30)
hsa:7124 TNF; tumor necrosis factor
hsa:7132 TNFRSF1A; tumor necrosis factor receptor superfamily, member 1A
hsa:94241 TP53INP1; tumor protein p53 inducible nuclear protein 1
hsa:706 TSPO; translocator protein (18kDa)
hsa:7412 VCAM1; vascular cell adhesion molecule 1
hsa:7416 VDAC1; voltage-dependent anion channel 1
hsa:7474 WNT5A; wingless-type MMTV integration site family, member 5A

hsa05152 Tuberculosis - Homo sapiens (human) (80)



cpd:C00338 Lipopolysaccharide
cpd:C01194 1-Phosphatidyl-D-myo-inositol
cpd:C01673 Calcitriol
hsa:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1)
hsa:317 APAF1; apoptotic peptidase activating factor 1
hsa:535 ATP6V0A1; ATPase, H+ transporting, lysosomal V0 subunit a1 (EC:3.6.3.14)
hsa:533 ATP6V0B; ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b (EC:3.6.3.14)
hsa:245972 ATP6V0D2; ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2 (EC:3.6.3.14)
hsa:572 BAD; BCL2-associated agonist of cell death
hsa:581 BAX; BCL2-associated X protein
hsa:596 BCL2; B-cell CLL/lymphoma 2
hsa:637 BID; BH3 interacting domain death agonist
hsa:718 C3; complement component 3 (EC:3.4.21.43)
hsa:805 CALM2; calmodulin 2 (phosphorylase kinase, delta) (EC:2.7.11.19)
hsa:808 CALM3; calmodulin 3 (phosphorylase kinase, delta) (EC:2.7.11.19)
hsa:836 CASP3; caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56)
hsa:841 CASP8; caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61)
hsa:842 CASP9; caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62)
hsa:929 CD14; CD14 molecule
hsa:972 CD74; CD74 molecule, major histocompatibility complex, class II invariant chain
hsa:4261 CIITA; class II, major histocompatibility complex, transactivator
hsa:1378 CR1; complement component (3b/4b) receptor 1 (Knops blood group)
hsa:1385 CREB1; cAMP responsive element binding protein 1
hsa:1509 CTSD; cathepsin D (EC:3.4.23.5)
hsa:54205 CYCS; cytochrome c, somatic
hsa:8772 FADD; Fas (TNFRSF6)-associated via death domain
hsa:2209 FCGR1A; Fc fragment of IgG, high affinity Ia, receptor (CD64)
hsa:2213 FCGR2B; Fc fragment of IgG, low affinity IIb, receptor (CD32)
hsa:2214 FCGR3A; Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
hsa:2215 FCGR3B; Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
hsa:3109 HLA-DMB; major histocompatibility complex, class II, DM beta
hsa:3118 HLA-DQA2; major histocompatibility complex, class II, DQ alpha 2
hsa:3329 HSPD1; heat shock 60kDa protein 1 (chaperonin)
hsa:3439 IFNA1; interferon, alpha 1
hsa:3443 IFNA6; interferon, alpha 6
hsa:3458 IFNG; interferon, gamma
hsa:3459 IFNGR1; interferon gamma receptor 1
hsa:3460 IFNGR2; interferon gamma receptor 2 (interferon gamma transducer 1)
hsa:3586 IL10; interleukin 10
hsa:3587 IL10RA; interleukin 10 receptor, alpha
hsa:3588 IL10RB; interleukin 10 receptor, beta
hsa:3592 IL12A; interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)
hsa:3593 IL12B; interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)
hsa:3606 IL18; interleukin 18 (interferon-gamma-inducing factor)
hsa:3552 IL1A; interleukin 1, alpha
hsa:3553 IL1B; interleukin 1, beta
hsa:3569 IL6; interleukin 6 (interferon, beta 2)
hsa:51135 IRAK4; interleukin-1 receptor-associated kinase 4 (EC:2.7.11.1)
hsa:3684 ITGAM; integrin, alpha M (complement component 3 receptor 3 subunit)
hsa:3687 ITGAX; integrin, alpha X (complement component 3 receptor 4 subunit)
hsa:3689 ITGB2; integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
hsa:3716 JAK1; Janus kinase 1 (EC:2.7.10.2)
hsa:3717 JAK2; Janus kinase 2 (EC:2.7.10.2)
hsa:3916 LAMP1; lysosomal-associated membrane protein 1
hsa:5594 MAPK1; mitogen-activated protein kinase 1 (EC:2.7.11.24)
hsa:1432 MAPK14; mitogen-activated protein kinase 14 (EC:2.7.11.24)
hsa:5595 MAPK3; mitogen-activated protein kinase 3 (EC:2.7.11.24)
hsa:5601 MAPK9; mitogen-activated protein kinase 9 (EC:2.7.11.24)
hsa:4615 MYD88; myeloid differentiation primary response gene (88)
hsa:4790 NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
hsa:64127 NOD2; nucleotide-binding oligomerization domain containing 2
hsa:4843 NOS2; nitric oxide synthase 2, inducible (EC:1.14.13.39)
hsa:5289 PIK3C3; phosphoinositide-3-kinase, class 3 (EC:2.7.1.137)
hsa:5530 PPP3CA; protein phosphatase 3, catalytic subunit, alpha isozyme (EC:3.1.3.16)
hsa:5532 PPP3CB; protein phosphatase 3, catalytic subunit, beta isozyme (EC:3.1.3.16)
hsa:5533 PPP3CC; protein phosphatase 3, catalytic subunit, gamma isozyme (EC:3.1.3.16)
hsa:5534 PPP3R1; protein phosphatase 3, regulatory subunit B, alpha (EC:3.1.3.16)
hsa:5535 PPP3R2; protein phosphatase 3, regulatory subunit B, beta (EC:3.1.3.16)
hsa:5869 RAB5B; RAB5B, member RAS oncogene family
hsa:5970 RELA; v-rel reticuloendotheliosis viral oncogene homolog A (avian)
hsa:6772 STAT1; signal transducer and activator of transcription 1, 91kDa
hsa:7040 TGFB1; transforming growth factor, beta 1
hsa:7097 TLR2; toll-like receptor 2
hsa:7099 TLR4; toll-like receptor 4
hsa:54106 TLR9; toll-like receptor 9
hsa:7124 TNF; tumor necrosis factor
hsa:7132 TNFRSF1A; tumor necrosis factor receptor superfamily, member 1A
hsa:8717 TRADD; TNFRSF1A-associated via death domain
hsa:7189 TRAF6; TNF receptor-associated factor 6, E3 ubiquitin protein ligase
hsa:7421 VDR; vitamin D (1,25- dihydroxyvitamin D3) receptor

hsa04010 MAPK signaling pathway - Homo sapiens (human) (72)



cpd:C00165 Diacylglycerol
cpd:C00338 Lipopolysaccharide
cpd:C00575 3',5'-Cyclic AMP
hsa:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1)
hsa:8913 CACNA1G; calcium channel, voltage-dependent, T type, alpha 1G subunit
hsa:836 CASP3; caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56)
hsa:929 CD14; CD14 molecule
hsa:1147 CHUK; conserved helix-loop-helix ubiquitous kinase (EC:2.7.11.10)
hsa:1649 DDIT3; DNA-damage-inducible transcript 3
hsa:1843 DUSP1; dual specificity phosphatase 1 (EC:3.1.3.16 3.1.3.48)
hsa:11221 DUSP10; dual specificity phosphatase 10 (EC:3.1.3.16 3.1.3.48)
hsa:11072 DUSP14; dual specificity phosphatase 14 (EC:3.1.3.16 3.1.3.48)
hsa:1846 DUSP4; dual specificity phosphatase 4 (EC:3.1.3.16 3.1.3.48)
hsa:1847 DUSP5; dual specificity phosphatase 5 (EC:3.1.3.16 3.1.3.48)
hsa:1848 DUSP6; dual specificity phosphatase 6 (EC:3.1.3.16 3.1.3.48)
hsa:355 FAS; Fas (TNF receptor superfamily, member 6)
hsa:2258 FGF13; fibroblast growth factor 13
hsa:2252 FGF7; fibroblast growth factor 7
hsa:2317 FLNB; filamin B, beta
hsa:2353 FOS; FBJ murine osteosarcoma viral oncogene homolog
hsa:1647 GADD45A; growth arrest and DNA-damage-inducible, alpha
hsa:4616 GADD45B; growth arrest and DNA-damage-inducible, beta
hsa:2768 GNA12; guanine nucleotide binding protein (G protein) alpha 12
hsa:55970 GNG12; guanine nucleotide binding protein (G protein), gamma 12
hsa:3312 HSPA8; heat shock 70kDa protein 8
hsa:3315 HSPB1; heat shock 27kDa protein 1
hsa:3552 IL1A; interleukin 1, alpha
hsa:3553 IL1B; interleukin 1, beta
hsa:3725 JUN; jun proto-oncogene
hsa:5605 MAP2K2; mitogen-activated protein kinase kinase 2 (EC:2.7.12.2)
hsa:5606 MAP2K3; mitogen-activated protein kinase kinase 3 (EC:2.7.12.2)
hsa:6416 MAP2K4; mitogen-activated protein kinase kinase 4 (EC:2.7.12.2)
hsa:5608 MAP2K6; mitogen-activated protein kinase kinase 6 (EC:2.7.12.2)
hsa:9020 MAP3K14; mitogen-activated protein kinase kinase kinase 14 (EC:2.7.11.25)
hsa:4216 MAP3K4; mitogen-activated protein kinase kinase kinase 4 (EC:2.7.11.25)
hsa:4217 MAP3K5; mitogen-activated protein kinase kinase kinase 5 (EC:2.7.11.25)
hsa:6885 MAP3K7; mitogen-activated protein kinase kinase kinase 7 (EC:2.7.11.25)
hsa:1326 MAP3K8; mitogen-activated protein kinase kinase kinase 8 (EC:2.7.11.25)
hsa:5871 MAP4K2; mitogen-activated protein kinase kinase kinase kinase 2 (EC:2.7.11.1)
hsa:5594 MAPK1; mitogen-activated protein kinase 1 (EC:2.7.11.24)
hsa:1432 MAPK14; mitogen-activated protein kinase 14 (EC:2.7.11.24)
hsa:5595 MAPK3; mitogen-activated protein kinase 3 (EC:2.7.11.24)
hsa:5601 MAPK9; mitogen-activated protein kinase 9 (EC:2.7.11.24)
hsa:4149 MAX; MYC associated factor X
hsa:4609 MYC; v-myc myelocytomatosis viral oncogene homolog (avian)
hsa:4790 NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
hsa:4791 NFKB2; nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
hsa:3164 NR4A1; nuclear receptor subfamily 4, group A, member 1
hsa:5154 PDGFA; platelet-derived growth factor alpha polypeptide
hsa:5155 PDGFB; platelet-derived growth factor beta polypeptide
hsa:5321 PLA2G4A; phospholipase A2, group IVA (cytosolic, calcium-dependent) (EC:3.1.1.5 3.1.1.4)
hsa:5530 PPP3CA; protein phosphatase 3, catalytic subunit, alpha isozyme (EC:3.1.3.16)
hsa:5532 PPP3CB; protein phosphatase 3, catalytic subunit, beta isozyme (EC:3.1.3.16)
hsa:5533 PPP3CC; protein phosphatase 3, catalytic subunit, gamma isozyme (EC:3.1.3.16)
hsa:5534 PPP3R1; protein phosphatase 3, regulatory subunit B, alpha (EC:3.1.3.16)
hsa:5535 PPP3R2; protein phosphatase 3, regulatory subunit B, beta (EC:3.1.3.16)
hsa:5578 PRKCA; protein kinase C, alpha (EC:2.7.11.13)
hsa:5579 PRKCB; protein kinase C, beta (EC:2.7.11.13)
hsa:9693 RAPGEF2; Rap guanine nucleotide exchange factor (GEF) 2
hsa:25780 RASGRP3; RAS guanyl releasing protein 3 (calcium and DAG-regulated)
hsa:5970 RELA; v-rel reticuloendotheliosis viral oncogene homolog A (avian)
hsa:5971 RELB; v-rel reticuloendotheliosis viral oncogene homolog B
hsa:6237 RRAS; related RAS viral (r-ras) oncogene homolog
hsa:6722 SRF; serum response factor (c-fos serum response element-binding transcription factor)
hsa:3925 STMN1; stathmin 1
hsa:10454 TAB1; TGF-beta activated kinase 1/MAP3K7 binding protein 1
hsa:23118 TAB2; TGF-beta activated kinase 1/MAP3K7 binding protein 2
hsa:7040 TGFB1; transforming growth factor, beta 1
hsa:7046 TGFBR1; transforming growth factor, beta receptor 1 (EC:2.7.11.30)
hsa:7124 TNF; tumor necrosis factor
hsa:7132 TNFRSF1A; tumor necrosis factor receptor superfamily, member 1A
hsa:7189 TRAF6; TNF receptor-associated factor 6, E3 ubiquitin protein ligase

hsa05164 Influenza A - Homo sapiens (human) (69)



cpd:C00027 Hydrogen peroxide
hsa:60 ACTB; actin, beta
hsa:71 ACTG1; actin, gamma 1
hsa:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1)
hsa:834 CASP1; caspase 1, apoptosis-related cysteine peptidase (EC:3.4.22.36)
hsa:842 CASP9; caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62)
hsa:6347 CCL2; chemokine (C-C motif) ligand 2
hsa:6352 CCL5; chemokine (C-C motif) ligand 5
hsa:4261 CIITA; class II, major histocompatibility complex, transactivator
hsa:3627 CXCL10; chemokine (C-X-C motif) ligand 10
hsa:54205 CYCS; cytochrome c, somatic
hsa:355 FAS; Fas (TNF receptor superfamily, member 6)
hsa:2224 FDPS; farnesyl diphosphate synthase (EC:2.5.1.1 2.5.1.10)
hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26)
hsa:3109 HLA-DMB; major histocompatibility complex, class II, DM beta
hsa:3118 HLA-DQA2; major histocompatibility complex, class II, DQ alpha 2
hsa:3312 HSPA8; heat shock 70kDa protein 8
hsa:3383 ICAM1; intercellular adhesion molecule 1
hsa:3439 IFNA1; interferon, alpha 1
hsa:3443 IFNA6; interferon, alpha 6
hsa:3458 IFNG; interferon, gamma
hsa:3459 IFNGR1; interferon gamma receptor 1
hsa:3460 IFNGR2; interferon gamma receptor 2 (interferon gamma transducer 1)
hsa:3592 IL12A; interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)
hsa:3593 IL12B; interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)
hsa:3606 IL18; interleukin 18 (interferon-gamma-inducing factor)
hsa:3552 IL1A; interleukin 1, alpha
hsa:3553 IL1B; interleukin 1, beta
hsa:90865 IL33; interleukin 33
hsa:3569 IL6; interleukin 6 (interferon, beta 2)
hsa:3576 IL8; interleukin 8
hsa:51135 IRAK4; interleukin-1 receptor-associated kinase 4 (EC:2.7.11.1)
hsa:3716 JAK1; Janus kinase 1 (EC:2.7.10.2)
hsa:3717 JAK2; Janus kinase 2 (EC:2.7.10.2)
hsa:3725 JUN; jun proto-oncogene
hsa:5605 MAP2K2; mitogen-activated protein kinase kinase 2 (EC:2.7.12.2)
hsa:5606 MAP2K3; mitogen-activated protein kinase kinase 3 (EC:2.7.12.2)
hsa:6416 MAP2K4; mitogen-activated protein kinase kinase 4 (EC:2.7.12.2)
hsa:5608 MAP2K6; mitogen-activated protein kinase kinase 6 (EC:2.7.12.2)
hsa:5594 MAPK1; mitogen-activated protein kinase 1 (EC:2.7.11.24)
hsa:1432 MAPK14; mitogen-activated protein kinase 14 (EC:2.7.11.24)
hsa:5595 MAPK3; mitogen-activated protein kinase 3 (EC:2.7.11.24)
hsa:5601 MAPK9; mitogen-activated protein kinase 9 (EC:2.7.11.24)
hsa:4599 MX1; myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
hsa:4615 MYD88; myeloid differentiation primary response gene (88)
hsa:4790 NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
hsa:4792 NFKBIA; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
hsa:4793 NFKBIB; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
hsa:4939 OAS2; 2'-5'-oligoadenylate synthetase 2, 69/71kDa (EC:2.7.7.-)
hsa:5290 PIK3CA; phosphoinositide-3-kinase, catalytic, alpha polypeptide (EC:2.7.11.1 2.7.1.153)
hsa:5291 PIK3CB; phosphoinositide-3-kinase, catalytic, beta polypeptide (EC:2.7.1.153)
hsa:5294 PIK3CG; phosphoinositide-3-kinase, catalytic, gamma polypeptide (EC:2.7.11.1 2.7.1.153)
hsa:5371 PML; promyelocytic leukemia
hsa:5578 PRKCA; protein kinase C, alpha (EC:2.7.11.13)
hsa:5579 PRKCB; protein kinase C, beta (EC:2.7.11.13)
hsa:5644 PRSS1; protease, serine, 1 (trypsin 1) (EC:3.4.21.4)
hsa:5970 RELA; v-rel reticuloendotheliosis viral oncogene homolog A (avian)
hsa:6041 RNASEL; ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) (EC:3.1.26.- 3.1.27.-)
hsa:91543 RSAD2; radical S-adenosyl methionine domain containing 2
hsa:9021 SOCS3; suppressor of cytokine signaling 3
hsa:6772 STAT1; signal transducer and activator of transcription 1, 91kDa
hsa:6773 STAT2; signal transducer and activator of transcription 2, 113kDa
hsa:7099 TLR4; toll-like receptor 4
hsa:51284 TLR7; toll-like receptor 7
hsa:7124 TNF; tumor necrosis factor
hsa:7132 TNFRSF1A; tumor necrosis factor receptor superfamily, member 1A
hsa:8743 TNFSF10; tumor necrosis factor (ligand) superfamily, member 10
hsa:7297 TYK2; tyrosine kinase 2 (EC:2.7.10.2)
hsa:7416 VDAC1; voltage-dependent anion channel 1

hsa05145 Toxoplasmosis - Homo sapiens (human) (67)



cpd:C06314 Lipoxin A4
hsa:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1)
hsa:240 ALOX5; arachidonate 5-lipoxygenase (EC:1.13.11.34)
hsa:572 BAD; BCL2-associated agonist of cell death
hsa:596 BCL2; B-cell CLL/lymphoma 2
hsa:329 BIRC2; baculoviral IAP repeat containing 2
hsa:330 BIRC3; baculoviral IAP repeat containing 3
hsa:836 CASP3; caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56)
hsa:841 CASP8; caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61)
hsa:842 CASP9; caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62)
hsa:1234 CCR5; chemokine (C-C motif) receptor 5 (gene/pseudogene)
hsa:958 CD40; CD40 molecule, TNF receptor superfamily member 5
hsa:959 CD40LG; CD40 ligand
hsa:1147 CHUK; conserved helix-loop-helix ubiquitous kinase (EC:2.7.11.10)
hsa:4261 CIITA; class II, major histocompatibility complex, transactivator
hsa:54205 CYCS; cytochrome c, somatic
hsa:3109 HLA-DMB; major histocompatibility complex, class II, DM beta
hsa:3118 HLA-DQA2; major histocompatibility complex, class II, DQ alpha 2
hsa:3312 HSPA8; heat shock 70kDa protein 8
hsa:3458 IFNG; interferon, gamma
hsa:3459 IFNGR1; interferon gamma receptor 1
hsa:3460 IFNGR2; interferon gamma receptor 2 (interferon gamma transducer 1)
hsa:3586 IL10; interleukin 10
hsa:3587 IL10RA; interleukin 10 receptor, alpha
hsa:3588 IL10RB; interleukin 10 receptor, beta
hsa:3592 IL12A; interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)
hsa:3593 IL12B; interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)
hsa:51135 IRAK4; interleukin-1 receptor-associated kinase 4 (EC:2.7.11.1)
hsa:345611 IRGM; immunity-related GTPase family, M
hsa:3655 ITGA6; integrin, alpha 6
hsa:3688 ITGB1; integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
hsa:3716 JAK1; Janus kinase 1 (EC:2.7.10.2)
hsa:3717 JAK2; Janus kinase 2 (EC:2.7.10.2)
hsa:3910 LAMA4; laminin, alpha 4
hsa:3914 LAMB3; laminin, beta 3
hsa:3949 LDLR; low density lipoprotein receptor
hsa:23643 LY96; lymphocyte antigen 96
hsa:5606 MAP2K3; mitogen-activated protein kinase kinase 3 (EC:2.7.12.2)
hsa:5608 MAP2K6; mitogen-activated protein kinase kinase 6 (EC:2.7.12.2)
hsa:6885 MAP3K7; mitogen-activated protein kinase kinase kinase 7 (EC:2.7.11.25)
hsa:5594 MAPK1; mitogen-activated protein kinase 1 (EC:2.7.11.24)
hsa:1432 MAPK14; mitogen-activated protein kinase 14 (EC:2.7.11.24)
hsa:5595 MAPK3; mitogen-activated protein kinase 3 (EC:2.7.11.24)
hsa:5601 MAPK9; mitogen-activated protein kinase 9 (EC:2.7.11.24)
hsa:4615 MYD88; myeloid differentiation primary response gene (88)
hsa:4790 NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
hsa:4792 NFKBIA; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
hsa:4793 NFKBIB; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
hsa:4843 NOS2; nitric oxide synthase 2, inducible (EC:1.14.13.39)
hsa:5163 PDK1; pyruvate dehydrogenase kinase, isozyme 1 (EC:2.7.11.2)
hsa:5290 PIK3CA; phosphoinositide-3-kinase, catalytic, alpha polypeptide (EC:2.7.11.1 2.7.1.153)
hsa:5291 PIK3CB; phosphoinositide-3-kinase, catalytic, beta polypeptide (EC:2.7.1.153)
hsa:5294 PIK3CG; phosphoinositide-3-kinase, catalytic, gamma polypeptide (EC:2.7.11.1 2.7.1.153)
hsa:5321 PLA2G4A; phospholipase A2, group IVA (cytosolic, calcium-dependent) (EC:3.1.1.5 3.1.1.4)
hsa:10105 PPIF; peptidylprolyl isomerase F (EC:5.2.1.8)
hsa:5970 RELA; v-rel reticuloendotheliosis viral oncogene homolog A (avian)
hsa:8651 SOCS1; suppressor of cytokine signaling 1
hsa:6772 STAT1; signal transducer and activator of transcription 1, 91kDa
hsa:10454 TAB1; TGF-beta activated kinase 1/MAP3K7 binding protein 1
hsa:23118 TAB2; TGF-beta activated kinase 1/MAP3K7 binding protein 2
hsa:7040 TGFB1; transforming growth factor, beta 1
hsa:7097 TLR2; toll-like receptor 2
hsa:7099 TLR4; toll-like receptor 4
hsa:7124 TNF; tumor necrosis factor
hsa:7132 TNFRSF1A; tumor necrosis factor receptor superfamily, member 1A
hsa:7189 TRAF6; TNF receptor-associated factor 6, E3 ubiquitin protein ligase
hsa:7297 TYK2; tyrosine kinase 2 (EC:2.7.10.2)

hsa05168 Herpes simplex infection - Homo sapiens (human) (66)



hsa:718 C3; complement component 3 (EC:3.4.21.43)
hsa:727 C5; complement component 5
hsa:836 CASP3; caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56)
hsa:841 CASP8; caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61)
hsa:6347 CCL2; chemokine (C-C motif) ligand 2
hsa:6352 CCL5; chemokine (C-C motif) ligand 5
hsa:972 CD74; CD74 molecule, major histocompatibility complex, class II invariant chain
hsa:1017 CDK2; cyclin-dependent kinase 2 (EC:2.7.11.22)
hsa:54205 CYCS; cytochrome c, somatic
hsa:1936 EEF1D; eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
hsa:8772 FADD; Fas (TNFRSF6)-associated via death domain
hsa:355 FAS; Fas (TNF receptor superfamily, member 6)
hsa:2353 FOS; FBJ murine osteosarcoma viral oncogene homolog
hsa:29915 HCFC2; host cell factor C2
hsa:3105 HLA-A; major histocompatibility complex, class I, A
hsa:3107 HLA-C; major histocompatibility complex, class I, C
hsa:3109 HLA-DMB; major histocompatibility complex, class II, DM beta
hsa:3118 HLA-DQA2; major histocompatibility complex, class II, DQ alpha 2
hsa:3134 HLA-F; major histocompatibility complex, class I, F
hsa:3135 HLA-G; major histocompatibility complex, class I, G
hsa:3190 HNRNPK; heterogeneous nuclear ribonucleoprotein K
hsa:3434 IFIT1; interferon-induced protein with tetratricopeptide repeats 1
hsa:3439 IFNA1; interferon, alpha 1
hsa:3443 IFNA6; interferon, alpha 6
hsa:3458 IFNG; interferon, gamma
hsa:3459 IFNGR1; interferon gamma receptor 1
hsa:3460 IFNGR2; interferon gamma receptor 2 (interferon gamma transducer 1)
hsa:3592 IL12A; interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)
hsa:3593 IL12B; interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)
hsa:3600 IL15; interleukin 15
hsa:3553 IL1B; interleukin 1, beta
hsa:3569 IL6; interleukin 6 (interferon, beta 2)
hsa:3716 JAK1; Janus kinase 1 (EC:2.7.10.2)
hsa:3717 JAK2; Janus kinase 2 (EC:2.7.10.2)
hsa:3725 JUN; jun proto-oncogene
hsa:4049 LTA; lymphotoxin alpha (TNF superfamily, member 1)
hsa:6885 MAP3K7; mitogen-activated protein kinase kinase kinase 7 (EC:2.7.11.25)
hsa:5601 MAPK9; mitogen-activated protein kinase 9 (EC:2.7.11.24)
hsa:4615 MYD88; myeloid differentiation primary response gene (88)
hsa:4790 NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
hsa:4792 NFKBIA; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
hsa:4793 NFKBIB; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
hsa:4939 OAS2; 2'-5'-oligoadenylate synthetase 2, 69/71kDa (EC:2.7.7.-)
hsa:8864 PER2; period homolog 2 (Drosophila)
hsa:8863 PER3; period homolog 3 (Drosophila)
hsa:5371 PML; promyelocytic leukemia
hsa:5781 PTPN11; protein tyrosine phosphatase, non-receptor type 11 (EC:3.1.3.48)
hsa:5819 PVRL2; poliovirus receptor-related 2 (herpesvirus entry mediator B)
hsa:5970 RELA; v-rel reticuloendotheliosis viral oncogene homolog A (avian)
hsa:6041 RNASEL; ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) (EC:3.1.26.- 3.1.27.-)
hsa:9021 SOCS3; suppressor of cytokine signaling 3
hsa:6772 STAT1; signal transducer and activator of transcription 1, 91kDa
hsa:6773 STAT2; signal transducer and activator of transcription 2, 113kDa
hsa:10454 TAB1; TGF-beta activated kinase 1/MAP3K7 binding protein 1
hsa:23118 TAB2; TGF-beta activated kinase 1/MAP3K7 binding protein 2
hsa:6890 TAP1; transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
hsa:6891 TAP2; transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
hsa:9519 TBPL1; TBP-like 1
hsa:7097 TLR2; toll-like receptor 2
hsa:54106 TLR9; toll-like receptor 9
hsa:7124 TNF; tumor necrosis factor
hsa:8764 TNFRSF14; tumor necrosis factor receptor superfamily, member 14
hsa:7132 TNFRSF1A; tumor necrosis factor receptor superfamily, member 1A
hsa:7185 TRAF1; TNF receptor-associated factor 1
hsa:7189 TRAF6; TNF receptor-associated factor 6, E3 ubiquitin protein ligase
hsa:7297 TYK2; tyrosine kinase 2 (EC:2.7.10.2)

hsa05169 Epstein-Barr virus infection - Homo sapiens (human) (65)



hsa:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1)
hsa:596 BCL2; B-cell CLL/lymphoma 2
hsa:683 BST1; bone marrow stromal cell antigen 1 (EC:3.2.2.5)
hsa:952 CD38; CD38 molecule (EC:3.2.2.5)
hsa:958 CD40; CD40 molecule, TNF receptor superfamily member 5
hsa:960 CD44; CD44 molecule (Indian blood group)
hsa:1017 CDK2; cyclin-dependent kinase 2 (EC:2.7.11.22)
hsa:1026 CDKN1A; cyclin-dependent kinase inhibitor 1A (p21, Cip1)
hsa:1027 CDKN1B; cyclin-dependent kinase inhibitor 1B (p27, Kip1)
hsa:1147 CHUK; conserved helix-loop-helix ubiquitous kinase (EC:2.7.11.10)
hsa:2208 FCER2; Fc fragment of IgE, low affinity II, receptor for (CD23)
hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26)
hsa:10014 HDAC5; histone deacetylase 5 (EC:3.5.1.98)
hsa:3105 HLA-A; major histocompatibility complex, class I, A
hsa:3107 HLA-C; major histocompatibility complex, class I, C
hsa:3118 HLA-DQA2; major histocompatibility complex, class II, DQ alpha 2
hsa:3134 HLA-F; major histocompatibility complex, class I, F
hsa:3135 HLA-G; major histocompatibility complex, class I, G
hsa:3312 HSPA8; heat shock 70kDa protein 8
hsa:3315 HSPB1; heat shock 27kDa protein 1
hsa:3383 ICAM1; intercellular adhesion molecule 1
hsa:3458 IFNG; interferon, gamma
hsa:3586 IL10; interleukin 10
hsa:3587 IL10RA; interleukin 10 receptor, alpha
hsa:3588 IL10RB; interleukin 10 receptor, beta
hsa:3683 ITGAL; integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
hsa:3716 JAK1; Janus kinase 1 (EC:2.7.10.2)
hsa:3718 JAK3; Janus kinase 3 (EC:2.7.10.2)
hsa:3725 JUN; jun proto-oncogene
hsa:5606 MAP2K3; mitogen-activated protein kinase kinase 3 (EC:2.7.12.2)
hsa:6416 MAP2K4; mitogen-activated protein kinase kinase 4 (EC:2.7.12.2)
hsa:5608 MAP2K6; mitogen-activated protein kinase kinase 6 (EC:2.7.12.2)
hsa:9020 MAP3K14; mitogen-activated protein kinase kinase kinase 14 (EC:2.7.11.25)
hsa:6885 MAP3K7; mitogen-activated protein kinase kinase kinase 7 (EC:2.7.11.25)
hsa:1432 MAPK14; mitogen-activated protein kinase 14 (EC:2.7.11.24)
hsa:5601 MAPK9; mitogen-activated protein kinase 9 (EC:2.7.11.24)
hsa:4609 MYC; v-myc myelocytomatosis viral oncogene homolog (avian)
hsa:4734 NEDD4; neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase (EC:6.3.2.-)
hsa:4790 NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
hsa:4791 NFKB2; nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
hsa:4792 NFKBIA; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
hsa:4793 NFKBIB; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
hsa:5290 PIK3CA; phosphoinositide-3-kinase, catalytic, alpha polypeptide (EC:2.7.11.1 2.7.1.153)
hsa:5291 PIK3CB; phosphoinositide-3-kinase, catalytic, beta polypeptide (EC:2.7.1.153)
hsa:5294 PIK3CG; phosphoinositide-3-kinase, catalytic, gamma polypeptide (EC:2.7.11.1 2.7.1.153)
hsa:5335 PLCG1; phospholipase C, gamma 1 (EC:3.1.4.11)
hsa:9533 POLR1C; polymerase (RNA) I polypeptide C, 30kDa
hsa:51082 POLR1D; polymerase (RNA) I polypeptide D, 16kDa
hsa:55718 POLR3E; polymerase (RNA) III (DNA directed) polypeptide E (80kD)
hsa:51728 POLR3K; polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
hsa:10213 PSMD14; proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 (EC:3.1.2.15)
hsa:5970 RELA; v-rel reticuloendotheliosis viral oncogene homolog A (avian)
hsa:5971 RELB; v-rel reticuloendotheliosis viral oncogene homolog B
hsa:10454 TAB1; TGF-beta activated kinase 1/MAP3K7 binding protein 1
hsa:23118 TAB2; TGF-beta activated kinase 1/MAP3K7 binding protein 2
hsa:9519 TBPL1; TBP-like 1
hsa:7128 TNFAIP3; tumor necrosis factor, alpha-induced protein 3 (EC:3.4.19.12)
hsa:8717 TRADD; TNFRSF1A-associated via death domain
hsa:7185 TRAF1; TNF receptor-associated factor 1
hsa:7189 TRAF6; TNF receptor-associated factor 6, E3 ubiquitin protein ligase
hsa:7297 TYK2; tyrosine kinase 2 (EC:2.7.10.2)
hsa:7431 VIM; vimentin
hsa:7529 YWHAB; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide
hsa:7533 YWHAH; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide
hsa:10971 YWHAQ; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide

hsa04062 Chemokine signaling pathway - Homo sapiens (human) (64)



cpd:C00165 Diacylglycerol
cpd:C00575 3',5'-Cyclic AMP
hsa:109 ADCY3; adenylate cyclase 3 (EC:4.6.1.1)
hsa:112 ADCY6; adenylate cyclase 6 (EC:4.6.1.1)
hsa:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1)
hsa:9564 BCAR1; breast cancer anti-estrogen resistance 1
hsa:6346 CCL1; chemokine (C-C motif) ligand 1
hsa:6356 CCL11; chemokine (C-C motif) ligand 11
hsa:6358 CCL14; chemokine (C-C motif) ligand 14
hsa:6361 CCL17; chemokine (C-C motif) ligand 17
hsa:6347 CCL2; chemokine (C-C motif) ligand 2
hsa:6364 CCL20; chemokine (C-C motif) ligand 20
hsa:6348 CCL3; chemokine (C-C motif) ligand 3
hsa:6351 CCL4; chemokine (C-C motif) ligand 4
hsa:6352 CCL5; chemokine (C-C motif) ligand 5
hsa:6354 CCL7; chemokine (C-C motif) ligand 7
hsa:6355 CCL8; chemokine (C-C motif) ligand 8
hsa:1230 CCR1; chemokine (C-C motif) receptor 1
hsa:729230 CCR2; chemokine (C-C motif) receptor 2
hsa:1232 CCR3; chemokine (C-C motif) receptor 3
hsa:1233 CCR4; chemokine (C-C motif) receptor 4
hsa:1234 CCR5; chemokine (C-C motif) receptor 5 (gene/pseudogene)
hsa:1235 CCR6; chemokine (C-C motif) receptor 6
hsa:1236 CCR7; chemokine (C-C motif) receptor 7
hsa:10803 CCR9; chemokine (C-C motif) receptor 9
hsa:1147 CHUK; conserved helix-loop-helix ubiquitous kinase (EC:2.7.11.10)
hsa:1524 CX3CR1; chemokine (C-X3-C motif) receptor 1
hsa:2919 CXCL1; chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
hsa:3627 CXCL10; chemokine (C-X-C motif) ligand 10
hsa:6373 CXCL11; chemokine (C-X-C motif) ligand 11
hsa:6387 CXCL12; chemokine (C-X-C motif) ligand 12
hsa:2920 CXCL2; chemokine (C-X-C motif) ligand 2
hsa:2921 CXCL3; chemokine (C-X-C motif) ligand 3
hsa:6374 CXCL5; chemokine (C-X-C motif) ligand 5
hsa:4283 CXCL9; chemokine (C-X-C motif) ligand 9
hsa:3579 CXCR2; chemokine (C-X-C motif) receptor 2
hsa:7852 CXCR4; chemokine (C-X-C motif) receptor 4
hsa:643 CXCR5; chemokine (C-X-C motif) receptor 5
hsa:59345 GNB4; guanine nucleotide binding protein (G protein), beta polypeptide 4
hsa:55970 GNG12; guanine nucleotide binding protein (G protein), gamma 12
hsa:2793 GNGT2; guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2
hsa:2869 GRK5; G protein-coupled receptor kinase 5 (EC:2.7.11.16)
hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26)
hsa:3576 IL8; interleukin 8
hsa:3717 JAK2; Janus kinase 2 (EC:2.7.10.2)
hsa:3718 JAK3; Janus kinase 3 (EC:2.7.10.2)
hsa:5594 MAPK1; mitogen-activated protein kinase 1 (EC:2.7.11.24)
hsa:5595 MAPK3; mitogen-activated protein kinase 3 (EC:2.7.11.24)
hsa:4790 NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
hsa:4792 NFKBIA; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
hsa:4793 NFKBIB; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
hsa:5196 PF4; platelet factor 4
hsa:5290 PIK3CA; phosphoinositide-3-kinase, catalytic, alpha polypeptide (EC:2.7.11.1 2.7.1.153)
hsa:5291 PIK3CB; phosphoinositide-3-kinase, catalytic, beta polypeptide (EC:2.7.1.153)
hsa:5294 PIK3CG; phosphoinositide-3-kinase, catalytic, gamma polypeptide (EC:2.7.11.1 2.7.1.153)
hsa:5330 PLCB2; phospholipase C, beta 2 (EC:3.1.4.11)
hsa:5331 PLCB3; phospholipase C, beta 3 (phosphatidylinositol-specific) (EC:3.1.4.11)
hsa:5473 PPBP; pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
hsa:57580 PREX1; phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1
hsa:5579 PRKCB; protein kinase C, beta (EC:2.7.11.13)
hsa:2185 PTK2B; PTK2B protein tyrosine kinase 2 beta (EC:2.7.10.2)
hsa:5970 RELA; v-rel reticuloendotheliosis viral oncogene homolog A (avian)
hsa:6772 STAT1; signal transducer and activator of transcription 1, 91kDa
hsa:6773 STAT2; signal transducer and activator of transcription 2, 113kDa

hsa04380 Osteoclast differentiation - Homo sapiens (human) (61)



cpd:C00027 Hydrogen peroxide
hsa:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1)
hsa:29760 BLNK; B-cell linker
hsa:1147 CHUK; conserved helix-loop-helix ubiquitous kinase (EC:2.7.11.10)
hsa:1385 CREB1; cAMP responsive element binding protein 1
hsa:1435 CSF1; colony stimulating factor 1 (macrophage) (EC:2.7.10.1)
hsa:1536 CYBB; cytochrome b-245, beta polypeptide
hsa:2209 FCGR1A; Fc fragment of IgG, high affinity Ia, receptor (CD64)
hsa:2213 FCGR2B; Fc fragment of IgG, low affinity IIb, receptor (CD32)
hsa:2214 FCGR3A; Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
hsa:2215 FCGR3B; Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
hsa:2274 FHL2; four and a half LIM domains 2
hsa:2353 FOS; FBJ murine osteosarcoma viral oncogene homolog
hsa:2355 FOSL2; FOS-like antigen 2
hsa:2534 FYN; FYN oncogene related to SRC, FGR, YES (EC:2.7.10.2)
hsa:3458 IFNG; interferon, gamma
hsa:3459 IFNGR1; interferon gamma receptor 1
hsa:3460 IFNGR2; interferon gamma receptor 2 (interferon gamma transducer 1)
hsa:3552 IL1A; interleukin 1, alpha
hsa:3553 IL1B; interleukin 1, beta
hsa:3690 ITGB3; integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
hsa:3716 JAK1; Janus kinase 1 (EC:2.7.10.2)
hsa:3725 JUN; jun proto-oncogene
hsa:3726 JUNB; jun B proto-oncogene
hsa:3932 LCK; lymphocyte-specific protein tyrosine kinase (EC:2.7.10.2)
hsa:5608 MAP2K6; mitogen-activated protein kinase kinase 6 (EC:2.7.12.2)
hsa:9020 MAP3K14; mitogen-activated protein kinase kinase kinase 14 (EC:2.7.11.25)
hsa:6885 MAP3K7; mitogen-activated protein kinase kinase kinase 7 (EC:2.7.11.25)
hsa:5594 MAPK1; mitogen-activated protein kinase 1 (EC:2.7.11.24)
hsa:1432 MAPK14; mitogen-activated protein kinase 14 (EC:2.7.11.24)
hsa:5595 MAPK3; mitogen-activated protein kinase 3 (EC:2.7.11.24)
hsa:5601 MAPK9; mitogen-activated protein kinase 9 (EC:2.7.11.24)
hsa:4772 NFATC1; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
hsa:4790 NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
hsa:4791 NFKB2; nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
hsa:4792 NFKBIA; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
hsa:27035 NOX1; NADPH oxidase 1
hsa:5290 PIK3CA; phosphoinositide-3-kinase, catalytic, alpha polypeptide (EC:2.7.11.1 2.7.1.153)
hsa:5291 PIK3CB; phosphoinositide-3-kinase, catalytic, beta polypeptide (EC:2.7.1.153)
hsa:5294 PIK3CG; phosphoinositide-3-kinase, catalytic, gamma polypeptide (EC:2.7.11.1 2.7.1.153)
hsa:5468 PPARG; peroxisome proliferator-activated receptor gamma
hsa:5530 PPP3CA; protein phosphatase 3, catalytic subunit, alpha isozyme (EC:3.1.3.16)
hsa:5532 PPP3CB; protein phosphatase 3, catalytic subunit, beta isozyme (EC:3.1.3.16)
hsa:5533 PPP3CC; protein phosphatase 3, catalytic subunit, gamma isozyme (EC:3.1.3.16)
hsa:5970 RELA; v-rel reticuloendotheliosis viral oncogene homolog A (avian)
hsa:5971 RELB; v-rel reticuloendotheliosis viral oncogene homolog B
hsa:8651 SOCS1; suppressor of cytokine signaling 1
hsa:9021 SOCS3; suppressor of cytokine signaling 3
hsa:6772 STAT1; signal transducer and activator of transcription 1, 91kDa
hsa:6773 STAT2; signal transducer and activator of transcription 2, 113kDa
hsa:10454 TAB1; TGF-beta activated kinase 1/MAP3K7 binding protein 1
hsa:23118 TAB2; TGF-beta activated kinase 1/MAP3K7 binding protein 2
hsa:7006 TEC; tec protein tyrosine kinase (EC:2.7.10.2)
hsa:7040 TGFB1; transforming growth factor, beta 1
hsa:7046 TGFBR1; transforming growth factor, beta receptor 1 (EC:2.7.11.30)
hsa:7124 TNF; tumor necrosis factor
hsa:8792 TNFRSF11A; tumor necrosis factor receptor superfamily, member 11a, NFKB activator
hsa:7132 TNFRSF1A; tumor necrosis factor receptor superfamily, member 1A
hsa:7189 TRAF6; TNF receptor-associated factor 6, E3 ubiquitin protein ligase
hsa:54209 TREM2; triggering receptor expressed on myeloid cells 2
hsa:7297 TYK2; tyrosine kinase 2 (EC:2.7.10.2)

hsa04630 Jak-STAT signaling pathway - Homo sapiens (human) (59)



hsa:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1)
hsa:595 CCND1; cyclin D1
hsa:1270 CNTF; ciliary neurotrophic factor
hsa:1437 CSF2; colony stimulating factor 2 (granulocyte-macrophage)
hsa:1439 CSF2RB; colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
hsa:1440 CSF3; colony stimulating factor 3 (granulocyte)
hsa:1489 CTF1; cardiotrophin 1
hsa:3439 IFNA1; interferon, alpha 1
hsa:3443 IFNA6; interferon, alpha 6
hsa:3458 IFNG; interferon, gamma
hsa:3459 IFNGR1; interferon gamma receptor 1
hsa:3460 IFNGR2; interferon gamma receptor 2 (interferon gamma transducer 1)
hsa:3586 IL10; interleukin 10
hsa:3587 IL10RA; interleukin 10 receptor, alpha
hsa:3588 IL10RB; interleukin 10 receptor, beta
hsa:3589 IL11; interleukin 11
hsa:3590 IL11RA; interleukin 11 receptor, alpha
hsa:3592 IL12A; interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)
hsa:3593 IL12B; interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)
hsa:3595 IL12RB2; interleukin 12 receptor, beta 2
hsa:3596 IL13; interleukin 13
hsa:3600 IL15; interleukin 15
hsa:3601 IL15RA; interleukin 15 receptor, alpha
hsa:3558 IL2; interleukin 2
hsa:50616 IL22; interleukin 22
hsa:3559 IL2RA; interleukin 2 receptor, alpha
hsa:3560 IL2RB; interleukin 2 receptor, beta
hsa:3561 IL2RG; interleukin 2 receptor, gamma
hsa:3562 IL3; interleukin 3 (colony-stimulating factor, multiple)
hsa:3563 IL3RA; interleukin 3 receptor, alpha (low affinity)
hsa:3565 IL4; interleukin 4
hsa:3566 IL4R; interleukin 4 receptor
hsa:3567 IL5; interleukin 5 (colony-stimulating factor, eosinophil)
hsa:3569 IL6; interleukin 6 (interferon, beta 2)
hsa:3572 IL6ST; interleukin 6 signal transducer (gp130, oncostatin M receptor)
hsa:3574 IL7; interleukin 7
hsa:3575 IL7R; interleukin 7 receptor
hsa:3716 JAK1; Janus kinase 1 (EC:2.7.10.2)
hsa:3717 JAK2; Janus kinase 2 (EC:2.7.10.2)
hsa:3718 JAK3; Janus kinase 3 (EC:2.7.10.2)
hsa:3976 LIF; leukemia inhibitory factor
hsa:4609 MYC; v-myc myelocytomatosis viral oncogene homolog (avian)
hsa:5008 OSM; oncostatin M
hsa:9063 PIAS2; protein inhibitor of activated STAT, 2
hsa:5290 PIK3CA; phosphoinositide-3-kinase, catalytic, alpha polypeptide (EC:2.7.11.1 2.7.1.153)
hsa:5291 PIK3CB; phosphoinositide-3-kinase, catalytic, beta polypeptide (EC:2.7.1.153)
hsa:5294 PIK3CG; phosphoinositide-3-kinase, catalytic, gamma polypeptide (EC:2.7.11.1 2.7.1.153)
hsa:5292 PIM1; pim-1 oncogene (EC:2.7.11.1)
hsa:5617 PRL; prolactin
hsa:5781 PTPN11; protein tyrosine phosphatase, non-receptor type 11 (EC:3.1.3.48)
hsa:8651 SOCS1; suppressor of cytokine signaling 1
hsa:9021 SOCS3; suppressor of cytokine signaling 3
hsa:10253 SPRY2; sprouty homolog 2 (Drosophila)
hsa:6772 STAT1; signal transducer and activator of transcription 1, 91kDa
hsa:6773 STAT2; signal transducer and activator of transcription 2, 113kDa
hsa:6775 STAT4; signal transducer and activator of transcription 4
hsa:6778 STAT6; signal transducer and activator of transcription 6, interleukin-4 induced
hsa:85480 TSLP; thymic stromal lymphopoietin
hsa:7297 TYK2; tyrosine kinase 2 (EC:2.7.10.2)

hsa05162 Measles - Homo sapiens (human) (56)



hsa:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1)
hsa:595 CCND1; cyclin D1
hsa:940 CD28; CD28 molecule
hsa:1017 CDK2; cyclin-dependent kinase 2 (EC:2.7.11.22)
hsa:1027 CDKN1B; cyclin-dependent kinase inhibitor 1B (p27, Kip1)
hsa:1147 CHUK; conserved helix-loop-helix ubiquitous kinase (EC:2.7.11.10)
hsa:355 FAS; Fas (TNF receptor superfamily, member 6)
hsa:2213 FCGR2B; Fc fragment of IgG, low affinity IIb, receptor (CD32)
hsa:2534 FYN; FYN oncogene related to SRC, FGR, YES (EC:2.7.10.2)
hsa:10399 GNB2L1; guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26)
hsa:3312 HSPA8; heat shock 70kDa protein 8
hsa:3439 IFNA1; interferon, alpha 1
hsa:3443 IFNA6; interferon, alpha 6
hsa:3458 IFNG; interferon, gamma
hsa:3459 IFNGR1; interferon gamma receptor 1
hsa:3460 IFNGR2; interferon gamma receptor 2 (interferon gamma transducer 1)
hsa:3592 IL12A; interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)
hsa:3593 IL12B; interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)
hsa:3596 IL13; interleukin 13
hsa:3552 IL1A; interleukin 1, alpha
hsa:3553 IL1B; interleukin 1, beta
hsa:3558 IL2; interleukin 2
hsa:3559 IL2RA; interleukin 2 receptor, alpha
hsa:3560 IL2RB; interleukin 2 receptor, beta
hsa:3561 IL2RG; interleukin 2 receptor, gamma
hsa:3565 IL4; interleukin 4
hsa:3569 IL6; interleukin 6 (interferon, beta 2)
hsa:51135 IRAK4; interleukin-1 receptor-associated kinase 4 (EC:2.7.11.1)
hsa:3716 JAK1; Janus kinase 1 (EC:2.7.10.2)
hsa:3717 JAK2; Janus kinase 2 (EC:2.7.10.2)
hsa:3718 JAK3; Janus kinase 3 (EC:2.7.10.2)
hsa:6885 MAP3K7; mitogen-activated protein kinase kinase kinase 7 (EC:2.7.11.25)
hsa:4478 MSN; moesin
hsa:4599 MX1; myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
hsa:4615 MYD88; myeloid differentiation primary response gene (88)
hsa:4790 NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
hsa:4792 NFKBIA; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
hsa:4793 NFKBIB; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
hsa:4939 OAS2; 2'-5'-oligoadenylate synthetase 2, 69/71kDa (EC:2.7.7.-)
hsa:5290 PIK3CA; phosphoinositide-3-kinase, catalytic, alpha polypeptide (EC:2.7.11.1 2.7.1.153)
hsa:5291 PIK3CB; phosphoinositide-3-kinase, catalytic, beta polypeptide (EC:2.7.1.153)
hsa:5294 PIK3CG; phosphoinositide-3-kinase, catalytic, gamma polypeptide (EC:2.7.11.1 2.7.1.153)
hsa:5970 RELA; v-rel reticuloendotheliosis viral oncogene homolog A (avian)
hsa:6504 SLAMF1; signaling lymphocytic activation molecule family member 1
hsa:6772 STAT1; signal transducer and activator of transcription 1, 91kDa
hsa:6773 STAT2; signal transducer and activator of transcription 2, 113kDa
hsa:23118 TAB2; TGF-beta activated kinase 1/MAP3K7 binding protein 2
hsa:7097 TLR2; toll-like receptor 2
hsa:7099 TLR4; toll-like receptor 4
hsa:51284 TLR7; toll-like receptor 7
hsa:54106 TLR9; toll-like receptor 9
hsa:7128 TNFAIP3; tumor necrosis factor, alpha-induced protein 3 (EC:3.4.19.12)
hsa:8743 TNFSF10; tumor necrosis factor (ligand) superfamily, member 10
hsa:7189 TRAF6; TNF receptor-associated factor 6, E3 ubiquitin protein ligase
hsa:7297 TYK2; tyrosine kinase 2 (EC:2.7.10.2)

hsa04510 Focal adhesion - Homo sapiens (human) (56)



hsa:60 ACTB; actin, beta
hsa:71 ACTG1; actin, gamma 1
hsa:87 ACTN1; actinin, alpha 1
hsa:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1)
hsa:572 BAD; BCL2-associated agonist of cell death
hsa:9564 BCAR1; breast cancer anti-estrogen resistance 1
hsa:596 BCL2; B-cell CLL/lymphoma 2
hsa:329 BIRC2; baculoviral IAP repeat containing 2
hsa:330 BIRC3; baculoviral IAP repeat containing 3
hsa:824 CAPN2; calpain 2, (m/II) large subunit (EC:3.4.22.53)
hsa:857 CAV1; caveolin 1, caveolae protein, 22kDa
hsa:858 CAV2; caveolin 2
hsa:595 CCND1; cyclin D1
hsa:1277 COL1A1; collagen, type I, alpha 1
hsa:1278 COL1A2; collagen, type I, alpha 2
hsa:1280 COL2A1; collagen, type II, alpha 1
hsa:1287 COL4A5; collagen, type IV, alpha 5
hsa:1291 COL6A1; collagen, type VI, alpha 1
hsa:1293 COL6A3; collagen, type VI, alpha 3
hsa:2064 ERBB2; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) (EC:2.7.10.1)
hsa:2317 FLNB; filamin B, beta
hsa:2321 FLT1; fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) (EC:2.7.10.1)
hsa:2335 FN1; fibronectin 1
hsa:2534 FYN; FYN oncogene related to SRC, FGR, YES (EC:2.7.10.2)
hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26)
hsa:3479 IGF1; insulin-like growth factor 1 (somatomedin C)
hsa:3611 ILK; integrin-linked kinase (EC:2.7.11.1)
hsa:3673 ITGA2; integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
hsa:3676 ITGA4; integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
hsa:3678 ITGA5; integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
hsa:3655 ITGA6; integrin, alpha 6
hsa:8516 ITGA8; integrin, alpha 8
hsa:3680 ITGA9; integrin, alpha 9
hsa:3688 ITGB1; integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
hsa:3690 ITGB3; integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
hsa:3693 ITGB5; integrin, beta 5
hsa:3695 ITGB7; integrin, beta 7
hsa:3725 JUN; jun proto-oncogene
hsa:3910 LAMA4; laminin, alpha 4
hsa:3914 LAMB3; laminin, beta 3
hsa:5594 MAPK1; mitogen-activated protein kinase 1 (EC:2.7.11.24)
hsa:5595 MAPK3; mitogen-activated protein kinase 3 (EC:2.7.11.24)
hsa:5601 MAPK9; mitogen-activated protein kinase 9 (EC:2.7.11.24)
hsa:5154 PDGFA; platelet-derived growth factor alpha polypeptide
hsa:5155 PDGFB; platelet-derived growth factor beta polypeptide
hsa:5228 PGF; placental growth factor
hsa:5290 PIK3CA; phosphoinositide-3-kinase, catalytic, alpha polypeptide (EC:2.7.11.1 2.7.1.153)
hsa:5291 PIK3CB; phosphoinositide-3-kinase, catalytic, beta polypeptide (EC:2.7.1.153)
hsa:5294 PIK3CG; phosphoinositide-3-kinase, catalytic, gamma polypeptide (EC:2.7.11.1 2.7.1.153)
hsa:5578 PRKCA; protein kinase C, alpha (EC:2.7.11.13)
hsa:5579 PRKCB; protein kinase C, beta (EC:2.7.11.13)
hsa:6696 SPP1; secreted phosphoprotein 1
hsa:7057 THBS1; thrombospondin 1
hsa:3371 TNC; tenascin C
hsa:7414 VCL; vinculin
hsa:7791 ZYX; zyxin

hsa05146 Amoebiasis - Homo sapiens (human) (56)



cpd:C00027 Hydrogen peroxide
cpd:C00062 L-Arginine
cpd:C00165 Diacylglycerol
cpd:C00219 Arachidonate
cpd:C00533 Nitric oxide
cpd:C00575 3',5'-Cyclic AMP
cpd:C00584 Prostaglandin E2
cpd:C02737 Phosphatidylserine
hsa:87 ACTN1; actinin, alpha 1
hsa:383 ARG1; arginase, liver (EC:3.5.3.1)
hsa:384 ARG2; arginase, type II (EC:3.5.3.1)
hsa:731 C8A; complement component 8, alpha polypeptide
hsa:732 C8B; complement component 8, beta polypeptide
hsa:836 CASP3; caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56)
hsa:929 CD14; CD14 molecule
hsa:912 CD1D; CD1d molecule
hsa:1277 COL1A1; collagen, type I, alpha 1
hsa:1278 COL1A2; collagen, type I, alpha 2
hsa:1280 COL2A1; collagen, type II, alpha 1
hsa:1287 COL4A5; collagen, type IV, alpha 5
hsa:1437 CSF2; colony stimulating factor 2 (granulocyte-macrophage)
hsa:2919 CXCL1; chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
hsa:2335 FN1; fibronectin 1
hsa:3315 HSPB1; heat shock 27kDa protein 1
hsa:3458 IFNG; interferon, gamma
hsa:3586 IL10; interleukin 10
hsa:3592 IL12A; interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)
hsa:3593 IL12B; interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)
hsa:3553 IL1B; interleukin 1, beta
hsa:3569 IL6; interleukin 6 (interferon, beta 2)
hsa:3576 IL8; interleukin 8
hsa:3684 ITGAM; integrin, alpha M (complement component 3 receptor 3 subunit)
hsa:3689 ITGB2; integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
hsa:3910 LAMA4; laminin, alpha 4
hsa:3914 LAMB3; laminin, beta 3
hsa:4790 NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
hsa:4843 NOS2; nitric oxide synthase 2, inducible (EC:1.14.13.39)
hsa:5290 PIK3CA; phosphoinositide-3-kinase, catalytic, alpha polypeptide (EC:2.7.11.1 2.7.1.153)
hsa:5291 PIK3CB; phosphoinositide-3-kinase, catalytic, beta polypeptide (EC:2.7.1.153)
hsa:5294 PIK3CG; phosphoinositide-3-kinase, catalytic, gamma polypeptide (EC:2.7.11.1 2.7.1.153)
hsa:5330 PLCB2; phospholipase C, beta 2 (EC:3.1.4.11)
hsa:5331 PLCB3; phospholipase C, beta 3 (phosphatidylinositol-specific) (EC:3.1.4.11)
hsa:5578 PRKCA; protein kinase C, alpha (EC:2.7.11.13)
hsa:5579 PRKCB; protein kinase C, beta (EC:2.7.11.13)
hsa:5869 RAB5B; RAB5B, member RAS oncogene family
hsa:5970 RELA; v-rel reticuloendotheliosis viral oncogene homolog A (avian)
hsa:5275 SERPINB13; serpin peptidase inhibitor, clade B (ovalbumin), member 13
hsa:5055 SERPINB2; serpin peptidase inhibitor, clade B (ovalbumin), member 2
hsa:6317 SERPINB3; serpin peptidase inhibitor, clade B (ovalbumin), member 3
hsa:6318 SERPINB4; serpin peptidase inhibitor, clade B (ovalbumin), member 4
hsa:5272 SERPINB9; serpin peptidase inhibitor, clade B (ovalbumin), member 9
hsa:7040 TGFB1; transforming growth factor, beta 1
hsa:7097 TLR2; toll-like receptor 2
hsa:7099 TLR4; toll-like receptor 4
hsa:7124 TNF; tumor necrosis factor
hsa:7414 VCL; vinculin

hsa05142 Chagas disease (American trypanosomiasis) - Homo sapiens (human) (55)



cpd:C00062 L-Arginine
cpd:C00533 Nitric oxide
cpd:C00575 3',5'-Cyclic AMP
hsa:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1)
hsa:624 BDKRB2; bradykinin receptor B2
hsa:712 C1QA; complement component 1, q subcomponent, A chain
hsa:714 C1QC; complement component 1, q subcomponent, C chain
hsa:718 C3; complement component 3 (EC:3.4.21.43)
hsa:811 CALR; calreticulin
hsa:841 CASP8; caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61)
hsa:6347 CCL2; chemokine (C-C motif) ligand 2
hsa:6348 CCL3; chemokine (C-C motif) ligand 3
hsa:6352 CCL5; chemokine (C-C motif) ligand 5
hsa:8837 CFLAR; CASP8 and FADD-like apoptosis regulator
hsa:1147 CHUK; conserved helix-loop-helix ubiquitous kinase (EC:2.7.11.10)
hsa:8772 FADD; Fas (TNFRSF6)-associated via death domain
hsa:355 FAS; Fas (TNF receptor superfamily, member 6)
hsa:2353 FOS; FBJ murine osteosarcoma viral oncogene homolog
hsa:3458 IFNG; interferon, gamma
hsa:3459 IFNGR1; interferon gamma receptor 1
hsa:3460 IFNGR2; interferon gamma receptor 2 (interferon gamma transducer 1)
hsa:3586 IL10; interleukin 10
hsa:3592 IL12A; interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)
hsa:3593 IL12B; interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)
hsa:3553 IL1B; interleukin 1, beta
hsa:3558 IL2; interleukin 2
hsa:3569 IL6; interleukin 6 (interferon, beta 2)
hsa:3576 IL8; interleukin 8
hsa:51135 IRAK4; interleukin-1 receptor-associated kinase 4 (EC:2.7.11.1)
hsa:3725 JUN; jun proto-oncogene
hsa:6416 MAP2K4; mitogen-activated protein kinase kinase 4 (EC:2.7.12.2)
hsa:5594 MAPK1; mitogen-activated protein kinase 1 (EC:2.7.11.24)
hsa:1432 MAPK14; mitogen-activated protein kinase 14 (EC:2.7.11.24)
hsa:5595 MAPK3; mitogen-activated protein kinase 3 (EC:2.7.11.24)
hsa:5601 MAPK9; mitogen-activated protein kinase 9 (EC:2.7.11.24)
hsa:4615 MYD88; myeloid differentiation primary response gene (88)
hsa:4790 NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
hsa:4792 NFKBIA; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
hsa:4843 NOS2; nitric oxide synthase 2, inducible (EC:1.14.13.39)
hsa:5290 PIK3CA; phosphoinositide-3-kinase, catalytic, alpha polypeptide (EC:2.7.11.1 2.7.1.153)
hsa:5291 PIK3CB; phosphoinositide-3-kinase, catalytic, beta polypeptide (EC:2.7.1.153)
hsa:5294 PIK3CG; phosphoinositide-3-kinase, catalytic, gamma polypeptide (EC:2.7.11.1 2.7.1.153)
hsa:5330 PLCB2; phospholipase C, beta 2 (EC:3.1.4.11)
hsa:5331 PLCB3; phospholipase C, beta 3 (phosphatidylinositol-specific) (EC:3.1.4.11)
hsa:5970 RELA; v-rel reticuloendotheliosis viral oncogene homolog A (avian)
hsa:5054 SERPINE1; serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
hsa:4087 SMAD2; SMAD family member 2
hsa:7040 TGFB1; transforming growth factor, beta 1
hsa:7046 TGFBR1; transforming growth factor, beta receptor 1 (EC:2.7.11.30)
hsa:7097 TLR2; toll-like receptor 2
hsa:7099 TLR4; toll-like receptor 4
hsa:54106 TLR9; toll-like receptor 9
hsa:7124 TNF; tumor necrosis factor
hsa:7132 TNFRSF1A; tumor necrosis factor receptor superfamily, member 1A
hsa:7189 TRAF6; TNF receptor-associated factor 6, E3 ubiquitin protein ligase

hsa00230 Purine metabolism - Homo sapiens (human) (53)



cpd:C00002 ATP
cpd:C00064 L-Glutamine
cpd:C00147 Adenine
cpd:C00212 Adenosine
cpd:C00242 Guanine
cpd:C00262 Hypoxanthine
cpd:C00294 Inosine
cpd:C00385 Xanthine
cpd:C00387 Guanosine
cpd:C00575 3',5'-Cyclic AMP
hsa:100 ADA; adenosine deaminase (EC:3.5.4.4)
hsa:109 ADCY3; adenylate cyclase 3 (EC:4.6.1.1)
hsa:112 ADCY6; adenylate cyclase 6 (EC:4.6.1.1)
hsa:132 ADK; adenosine kinase (EC:2.7.1.20)
hsa:204 AK2; adenylate kinase 2 (EC:2.7.4.3)
hsa:270 AMPD1; adenosine monophosphate deaminase 1 (EC:3.5.4.6)
hsa:271 AMPD2; adenosine monophosphate deaminase 2 (EC:3.5.4.6)
hsa:272 AMPD3; adenosine monophosphate deaminase 3 (EC:3.5.4.6)
hsa:353 APRT; adenine phosphoribosyltransferase (EC:2.4.2.7)
hsa:1633 DCK; deoxycytidine kinase (EC:2.7.1.74)
hsa:1716 DGUOK; deoxyguanosine kinase (EC:2.7.1.113)
hsa:5167 ENPP1; ectonucleotide pyrophosphatase/phosphodiesterase 1 (EC:3.1.4.1 3.6.1.9)
hsa:2766 GMPR; guanosine monophosphate reductase (EC:1.7.1.7)
hsa:51292 GMPR2; guanosine monophosphate reductase 2 (EC:1.7.1.7)
hsa:374659 HDDC3; HD domain containing 3 (EC:3.1.7.2)
hsa:3251 HPRT1; hypoxanthine phosphoribosyltransferase 1 (EC:2.4.2.8)
hsa:4830 NME1; non-metastatic cells 1, protein (NM23A) expressed in (EC:2.7.4.6)
hsa:4831 NME2; non-metastatic cells 2, protein (NM23B) expressed in (EC:2.7.4.6 2.7.13.3)
hsa:4833 NME4; non-metastatic cells 4, protein expressed in (EC:2.7.4.6)
hsa:10201 NME6; non-metastatic cells 6, protein expressed in (nucleoside-diphosphate kinase) (EC:2.7.4.6)
hsa:93034 NT5C1B; 5'-nucleotidase, cytosolic IB (EC:3.1.3.5)
hsa:4907 NT5E; 5'-nucleotidase, ecto (CD73) (EC:3.1.3.5)
hsa:5137 PDE1C; phosphodiesterase 1C, calmodulin-dependent 70kDa (EC:3.1.4.17)
hsa:5138 PDE2A; phosphodiesterase 2A, cGMP-stimulated (EC:3.1.4.17)
hsa:5142 PDE4B; phosphodiesterase 4B, cAMP-specific (EC:3.1.4.17)
hsa:5152 PDE9A; phosphodiesterase 9A (EC:3.1.4.35)
hsa:5198 PFAS; phosphoribosylformylglycinamidine synthase (EC:6.3.5.3)
hsa:55276 PGM2; phosphoglucomutase 2 (EC:5.4.2.2 5.4.2.7)
hsa:5315 PKM2; pyruvate kinase, muscle (EC:2.7.1.40)
hsa:4860 PNP; purine nucleoside phosphorylase (EC:2.4.2.1)
hsa:54107 POLE3; polymerase (DNA directed), epsilon 3 (p17 subunit) (EC:2.7.7.7)
hsa:25885 POLR1A; polymerase (RNA) I polypeptide A, 194kDa (EC:2.7.7.6)
hsa:84172 POLR1B; polymerase (RNA) I polypeptide B, 128kDa (EC:2.7.7.6)
hsa:9533 POLR1C; polymerase (RNA) I polypeptide C, 30kDa
hsa:51082 POLR1D; polymerase (RNA) I polypeptide D, 16kDa
hsa:64425 POLR1E; polymerase (RNA) I polypeptide E, 53kDa
hsa:55718 POLR3E; polymerase (RNA) III (DNA directed) polypeptide E (80kD)
hsa:51728 POLR3K; polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
hsa:5471 PPAT; phosphoribosyl pyrophosphate amidotransferase (EC:2.4.2.14)
hsa:5557 PRIM1; primase, DNA, polypeptide 1 (49kDa) (EC:2.7.7.-)
hsa:50484 RRM2B; ribonucleotide reductase M2 B (TP53 inducible) (EC:1.17.4.1)
hsa:221830 TWISTNB; TWIST neighbor
hsa:7498 XDH; xanthine dehydrogenase (EC:1.17.1.4 1.17.3.2)

hsa05010 Alzheimer's disease - Homo sapiens (human) (52)



cpd:C00027 Hydrogen peroxide
cpd:C00533 Nitric oxide
hsa:102 ADAM10; ADAM metallopeptidase domain 10 (EC:3.4.24.81)
hsa:317 APAF1; apoptotic peptidase activating factor 1
hsa:322 APBB1; amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
hsa:348 APOE; apolipoprotein E
hsa:351 APP; amyloid beta (A4) precursor protein
hsa:498 ATP5A1; ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle
hsa:513 ATP5D; ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit (EC:3.6.1.14)
hsa:516 ATP5G1; ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)
hsa:4508 ATP6; ATP synthase F0 subunit 6
hsa:572 BAD; BCL2-associated agonist of cell death
hsa:637 BID; BH3 interacting domain death agonist
hsa:805 CALM2; calmodulin 2 (phosphorylase kinase, delta) (EC:2.7.11.19)
hsa:808 CALM3; calmodulin 3 (phosphorylase kinase, delta) (EC:2.7.11.19)
hsa:823 CAPN1; calpain 1, (mu/I) large subunit (EC:3.4.22.52)
hsa:824 CAPN2; calpain 2, (m/II) large subunit (EC:3.4.22.53)
hsa:836 CASP3; caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56)
hsa:840 CASP7; caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60)
hsa:841 CASP8; caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61)
hsa:842 CASP9; caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62)
hsa:4514 COX3; cytochrome c oxidase III
hsa:1350 COX7C; cytochrome c oxidase subunit VIIc (EC:1.9.3.1)
hsa:54205 CYCS; cytochrome c, somatic
hsa:4519 CYTB; cytochrome b
hsa:8772 FADD; Fas (TNFRSF6)-associated via death domain
hsa:355 FAS; Fas (TNF receptor superfamily, member 6)
hsa:2597 GAPDH; glyceraldehyde-3-phosphate dehydrogenase (EC:1.2.1.12)
hsa:2903 GRIN2A; glutamate receptor, ionotropic, N-methyl D-aspartate 2A
hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26)
hsa:3028 HSD17B10; hydroxysteroid (17-beta) dehydrogenase 10 (EC:1.1.1.35 1.1.1.178)
hsa:3553 IL1B; interleukin 1, beta
hsa:3708 ITPR1; inositol 1,4,5-trisphosphate receptor, type 1
hsa:4023 LPL; lipoprotein lipase (EC:3.1.1.34)
hsa:4035 LRP1; low density lipoprotein receptor-related protein 1
hsa:5594 MAPK1; mitogen-activated protein kinase 1 (EC:2.7.11.24)
hsa:5595 MAPK3; mitogen-activated protein kinase 3 (EC:2.7.11.24)
hsa:8883 NAE1; NEDD8 activating enzyme E1 subunit 1
hsa:4725 NDUFS5; NADH dehydrogenase (ubiquinone) Fe-S protein 5, 15kDa (NADH-coenzyme Q reductase)
hsa:374291 NDUFS7; NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase) (EC:1.6.5.3 1.6.99.3)
hsa:4731 NDUFV3; NADH dehydrogenase (ubiquinone) flavoprotein 3, 10kDa (EC:1.6.5.3)
hsa:4842 NOS1; nitric oxide synthase 1 (neuronal) (EC:1.14.13.39)
hsa:5330 PLCB2; phospholipase C, beta 2 (EC:3.1.4.11)
hsa:5331 PLCB3; phospholipase C, beta 3 (phosphatidylinositol-specific) (EC:3.1.4.11)
hsa:5530 PPP3CA; protein phosphatase 3, catalytic subunit, alpha isozyme (EC:3.1.3.16)
hsa:5532 PPP3CB; protein phosphatase 3, catalytic subunit, beta isozyme (EC:3.1.3.16)
hsa:5533 PPP3CC; protein phosphatase 3, catalytic subunit, gamma isozyme (EC:3.1.3.16)
hsa:5534 PPP3R1; protein phosphatase 3, regulatory subunit B, alpha (EC:3.1.3.16)
hsa:5535 PPP3R2; protein phosphatase 3, regulatory subunit B, beta (EC:3.1.3.16)
hsa:55851 PSENEN; presenilin enhancer 2 homolog (C. elegans)
hsa:7124 TNF; tumor necrosis factor
hsa:7132 TNFRSF1A; tumor necrosis factor receptor superfamily, member 1A

hsa05133 Pertussis - Homo sapiens (human) (52)



cpd:C00002 ATP
cpd:C00238 Potassium cation
cpd:C00338 Lipopolysaccharide
cpd:C00374 Heparin
cpd:C00575 3',5'-Cyclic AMP
hsa:712 C1QA; complement component 1, q subcomponent, A chain
hsa:714 C1QC; complement component 1, q subcomponent, C chain
hsa:715 C1R; complement component 1, r subcomponent (EC:3.4.21.41)
hsa:716 C1S; complement component 1, s subcomponent (EC:3.4.21.42)
hsa:718 C3; complement component 3 (EC:3.4.21.43)
hsa:720 C4A; complement component 4A (Rodgers blood group)
hsa:721 C4B; complement component 4B (Chido blood group)
hsa:722 C4BPA; complement component 4 binding protein, alpha
hsa:727 C5; complement component 5
hsa:805 CALM2; calmodulin 2 (phosphorylase kinase, delta) (EC:2.7.11.19)
hsa:808 CALM3; calmodulin 3 (phosphorylase kinase, delta) (EC:2.7.11.19)
hsa:834 CASP1; caspase 1, apoptosis-related cysteine peptidase (EC:3.4.22.36)
hsa:836 CASP3; caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56)
hsa:840 CASP7; caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60)
hsa:929 CD14; CD14 molecule
hsa:1072 CFL1; cofilin 1 (non-muscle)
hsa:6374 CXCL5; chemokine (C-X-C motif) ligand 5
hsa:2353 FOS; FBJ murine osteosarcoma viral oncogene homolog
hsa:3586 IL10; interleukin 10
hsa:3592 IL12A; interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)
hsa:3593 IL12B; interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)
hsa:3552 IL1A; interleukin 1, alpha
hsa:3553 IL1B; interleukin 1, beta
hsa:3569 IL6; interleukin 6 (interferon, beta 2)
hsa:3576 IL8; interleukin 8
hsa:51135 IRAK4; interleukin-1 receptor-associated kinase 4 (EC:2.7.11.1)
hsa:3659 IRF1; interferon regulatory factor 1
hsa:3394 IRF8; interferon regulatory factor 8
hsa:3678 ITGA5; integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
hsa:3684 ITGAM; integrin, alpha M (complement component 3 receptor 3 subunit)
hsa:3688 ITGB1; integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
hsa:3689 ITGB2; integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
hsa:3725 JUN; jun proto-oncogene
hsa:23643 LY96; lymphocyte antigen 96
hsa:5594 MAPK1; mitogen-activated protein kinase 1 (EC:2.7.11.24)
hsa:1432 MAPK14; mitogen-activated protein kinase 14 (EC:2.7.11.24)
hsa:5595 MAPK3; mitogen-activated protein kinase 3 (EC:2.7.11.24)
hsa:5601 MAPK9; mitogen-activated protein kinase 9 (EC:2.7.11.24)
hsa:4615 MYD88; myeloid differentiation primary response gene (88)
hsa:4790 NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
hsa:10392 NOD1; nucleotide-binding oligomerization domain containing 1
hsa:4843 NOS2; nitric oxide synthase 2, inducible (EC:1.14.13.39)
hsa:5970 RELA; v-rel reticuloendotheliosis viral oncogene homolog A (avian)
hsa:710 SERPING1; serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
hsa:7099 TLR4; toll-like receptor 4
hsa:7124 TNF; tumor necrosis factor
hsa:7189 TRAF6; TNF receptor-associated factor 6, E3 ubiquitin protein ligase

hsa04620 Toll-like receptor signaling pathway - Homo sapiens (human) (52)



hsa:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1)
hsa:841 CASP8; caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61)
hsa:6348 CCL3; chemokine (C-C motif) ligand 3
hsa:6351 CCL4; chemokine (C-C motif) ligand 4
hsa:6352 CCL5; chemokine (C-C motif) ligand 5
hsa:929 CD14; CD14 molecule
hsa:958 CD40; CD40 molecule, TNF receptor superfamily member 5
hsa:941 CD80; CD80 molecule
hsa:942 CD86; CD86 molecule
hsa:1147 CHUK; conserved helix-loop-helix ubiquitous kinase (EC:2.7.11.10)
hsa:3627 CXCL10; chemokine (C-X-C motif) ligand 10
hsa:6373 CXCL11; chemokine (C-X-C motif) ligand 11
hsa:4283 CXCL9; chemokine (C-X-C motif) ligand 9
hsa:8772 FADD; Fas (TNFRSF6)-associated via death domain
hsa:2353 FOS; FBJ murine osteosarcoma viral oncogene homolog
hsa:3439 IFNA1; interferon, alpha 1
hsa:3443 IFNA6; interferon, alpha 6
hsa:3592 IL12A; interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)
hsa:3593 IL12B; interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)
hsa:3553 IL1B; interleukin 1, beta
hsa:3569 IL6; interleukin 6 (interferon, beta 2)
hsa:3576 IL8; interleukin 8
hsa:51135 IRAK4; interleukin-1 receptor-associated kinase 4 (EC:2.7.11.1)
hsa:3725 JUN; jun proto-oncogene
hsa:23643 LY96; lymphocyte antigen 96
hsa:5605 MAP2K2; mitogen-activated protein kinase kinase 2 (EC:2.7.12.2)
hsa:5606 MAP2K3; mitogen-activated protein kinase kinase 3 (EC:2.7.12.2)
hsa:6416 MAP2K4; mitogen-activated protein kinase kinase 4 (EC:2.7.12.2)
hsa:5608 MAP2K6; mitogen-activated protein kinase kinase 6 (EC:2.7.12.2)
hsa:6885 MAP3K7; mitogen-activated protein kinase kinase kinase 7 (EC:2.7.11.25)
hsa:1326 MAP3K8; mitogen-activated protein kinase kinase kinase 8 (EC:2.7.11.25)
hsa:5594 MAPK1; mitogen-activated protein kinase 1 (EC:2.7.11.24)
hsa:1432 MAPK14; mitogen-activated protein kinase 14 (EC:2.7.11.24)
hsa:5595 MAPK3; mitogen-activated protein kinase 3 (EC:2.7.11.24)
hsa:5601 MAPK9; mitogen-activated protein kinase 9 (EC:2.7.11.24)
hsa:4615 MYD88; myeloid differentiation primary response gene (88)
hsa:4790 NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
hsa:4792 NFKBIA; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
hsa:5290 PIK3CA; phosphoinositide-3-kinase, catalytic, alpha polypeptide (EC:2.7.11.1 2.7.1.153)
hsa:5291 PIK3CB; phosphoinositide-3-kinase, catalytic, beta polypeptide (EC:2.7.1.153)
hsa:5294 PIK3CG; phosphoinositide-3-kinase, catalytic, gamma polypeptide (EC:2.7.11.1 2.7.1.153)
hsa:5970 RELA; v-rel reticuloendotheliosis viral oncogene homolog A (avian)
hsa:6696 SPP1; secreted phosphoprotein 1
hsa:6772 STAT1; signal transducer and activator of transcription 1, 91kDa
hsa:10454 TAB1; TGF-beta activated kinase 1/MAP3K7 binding protein 1
hsa:23118 TAB2; TGF-beta activated kinase 1/MAP3K7 binding protein 2
hsa:7097 TLR2; toll-like receptor 2
hsa:7099 TLR4; toll-like receptor 4
hsa:51284 TLR7; toll-like receptor 7
hsa:54106 TLR9; toll-like receptor 9
hsa:7124 TNF; tumor necrosis factor
hsa:7189 TRAF6; TNF receptor-associated factor 6, E3 ubiquitin protein ligase

hsa05202 Transcriptional misregulation in cancer - Homo sapiens (human) (52)



hsa:472 ATM; ataxia telangiectasia mutated (EC:2.7.11.1)
hsa:597 BCL2A1; BCL2-related protein A1
hsa:330 BIRC3; baculoviral IAP repeat containing 3
hsa:1236 CCR7; chemokine (C-C motif) receptor 7
hsa:929 CD14; CD14 molecule
hsa:958 CD40; CD40 molecule, TNF receptor superfamily member 5
hsa:942 CD86; CD86 molecule
hsa:1026 CDKN1A; cyclin-dependent kinase inhibitor 1A (p21, Cip1)
hsa:1027 CDKN1B; cyclin-dependent kinase inhibitor 1B (p27, Kip1)
hsa:1050 CEBPA; CCAAT/enhancer binding protein (C/EBP), alpha
hsa:1437 CSF2; colony stimulating factor 2 (granulocyte-macrophage)
hsa:1649 DDIT3; DNA-damage-inducible transcript 3
hsa:1848 DUSP6; dual specificity phosphatase 6 (EC:3.1.3.16 3.1.3.48)
hsa:1991 ELANE; elastase, neutrophil expressed (EC:3.4.21.37)
hsa:2115 ETV1; ets variant 1
hsa:2138 EYA1; eyes absent homolog 1 (Drosophila) (EC:3.1.3.48)
hsa:2209 FCGR1A; Fc fragment of IgG, high affinity Ia, receptor (CD64)
hsa:2321 FLT1; fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) (EC:2.7.10.1)
hsa:3002 GZMB; granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) (EC:3.4.21.79)
hsa:8350 HIST1H3A; histone cluster 1, H3a
hsa:8352 HIST1H3C; histone cluster 1, H3c
hsa:8357 HIST1H3H; histone cluster 1, H3h
hsa:8356 HIST1H3J; histone cluster 1, H3j
hsa:3248 HPGD; hydroxyprostaglandin dehydrogenase 15-(NAD) (EC:1.1.1.141)
hsa:3398 ID2; inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
hsa:3479 IGF1; insulin-like growth factor 1 (somatomedin C)
hsa:3486 IGFBP3; insulin-like growth factor binding protein 3
hsa:3560 IL2RB; interleukin 2 receptor, beta
hsa:3562 IL3; interleukin 3 (colony-stimulating factor, multiple)
hsa:3569 IL6; interleukin 6 (interferon, beta 2)
hsa:3576 IL8; interleukin 8
hsa:3684 ITGAM; integrin, alpha M (complement component 3 receptor 3 subunit)
hsa:3695 ITGB7; integrin, beta 7
hsa:3728 JUP; junction plakoglobin
hsa:4094 MAF; v-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian)
hsa:4149 MAX; MYC associated factor X
hsa:4314 MMP3; matrix metallopeptidase 3 (stromelysin 1, progelatinase) (EC:3.4.24.17)
hsa:4318 MMP9; matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35)
hsa:4609 MYC; v-myc myelocytomatosis viral oncogene homolog (avian)
hsa:4790 NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
hsa:8013 NR4A3; nuclear receptor subfamily 4, group A, member 3
hsa:5154 PDGFA; platelet-derived growth factor alpha polypeptide
hsa:5155 PDGFB; platelet-derived growth factor beta polypeptide
hsa:8864 PER2; period homolog 2 (Drosophila)
hsa:5328 PLAU; plasminogen activator, urokinase (EC:3.4.21.73)
hsa:5371 PML; promyelocytic leukemia
hsa:5468 PPARG; peroxisome proliferator-activated receptor gamma
hsa:171558 PTCRA; pre T-cell antigen receptor alpha
hsa:5966 REL; v-rel reticuloendotheliosis viral oncogene homolog (avian)
hsa:5970 RELA; v-rel reticuloendotheliosis viral oncogene homolog A (avian)
hsa:30012 TLX3; T-cell leukemia homeobox 3
hsa:7185 TRAF1; TNF receptor-associated factor 1

hsa05140 Leishmaniasis - Homo sapiens (human) (51)



cpd:C00195 N-Acylsphingosine
cpd:C00219 Arachidonate
cpd:C00533 Nitric oxide
cpd:C00584 Prostaglandin E2
cpd:C02737 Phosphatidylserine
hsa:718 C3; complement component 3 (EC:3.4.21.43)
hsa:1378 CR1; complement component (3b/4b) receptor 1 (Knops blood group)
hsa:2209 FCGR1A; Fc fragment of IgG, high affinity Ia, receptor (CD64)
hsa:2214 FCGR3A; Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
hsa:2215 FCGR3B; Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
hsa:2353 FOS; FBJ murine osteosarcoma viral oncogene homolog
hsa:3109 HLA-DMB; major histocompatibility complex, class II, DM beta
hsa:3118 HLA-DQA2; major histocompatibility complex, class II, DQ alpha 2
hsa:3458 IFNG; interferon, gamma
hsa:3459 IFNGR1; interferon gamma receptor 1
hsa:3460 IFNGR2; interferon gamma receptor 2 (interferon gamma transducer 1)
hsa:3586 IL10; interleukin 10
hsa:3592 IL12A; interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)
hsa:3593 IL12B; interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)
hsa:3552 IL1A; interleukin 1, alpha
hsa:3553 IL1B; interleukin 1, beta
hsa:3565 IL4; interleukin 4
hsa:51135 IRAK4; interleukin-1 receptor-associated kinase 4 (EC:2.7.11.1)
hsa:3676 ITGA4; integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
hsa:3684 ITGAM; integrin, alpha M (complement component 3 receptor 3 subunit)
hsa:3688 ITGB1; integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
hsa:3689 ITGB2; integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
hsa:3716 JAK1; Janus kinase 1 (EC:2.7.10.2)
hsa:3717 JAK2; Janus kinase 2 (EC:2.7.10.2)
hsa:3725 JUN; jun proto-oncogene
hsa:6885 MAP3K7; mitogen-activated protein kinase kinase kinase 7 (EC:2.7.11.25)
hsa:5594 MAPK1; mitogen-activated protein kinase 1 (EC:2.7.11.24)
hsa:1432 MAPK14; mitogen-activated protein kinase 14 (EC:2.7.11.24)
hsa:5595 MAPK3; mitogen-activated protein kinase 3 (EC:2.7.11.24)
hsa:65108 MARCKSL1; MARCKS-like 1
hsa:4615 MYD88; myeloid differentiation primary response gene (88)
hsa:4790 NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
hsa:4792 NFKBIA; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
hsa:4793 NFKBIB; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
hsa:4843 NOS2; nitric oxide synthase 2, inducible (EC:1.14.13.39)
hsa:5579 PRKCB; protein kinase C, beta (EC:2.7.11.13)
hsa:5743 PTGS2; prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1)
hsa:5970 RELA; v-rel reticuloendotheliosis viral oncogene homolog A (avian)
hsa:6772 STAT1; signal transducer and activator of transcription 1, 91kDa
hsa:10454 TAB1; TGF-beta activated kinase 1/MAP3K7 binding protein 1
hsa:23118 TAB2; TGF-beta activated kinase 1/MAP3K7 binding protein 2
hsa:7040 TGFB1; transforming growth factor, beta 1
hsa:7097 TLR2; toll-like receptor 2
hsa:7099 TLR4; toll-like receptor 4
hsa:7124 TNF; tumor necrosis factor
hsa:7189 TRAF6; TNF receptor-associated factor 6, E3 ubiquitin protein ligase

hsa04514 Cell adhesion molecules (CAMs) - Homo sapiens (human) (50)



hsa:214 ALCAM; activated leukocyte cell adhesion molecule
hsa:914 CD2; CD2 molecule
hsa:933 CD22; CD22 molecule
hsa:10666 CD226; CD226 molecule
hsa:29126 CD274; CD274 molecule
hsa:80381 CD276; CD276 molecule
hsa:940 CD28; CD28 molecule
hsa:920 CD4; CD4 molecule
hsa:958 CD40; CD40 molecule, TNF receptor superfamily member 5
hsa:959 CD40LG; CD40 ligand
hsa:941 CD80; CD80 molecule
hsa:942 CD86; CD86 molecule
hsa:4267 CD99; CD99 molecule
hsa:1013 CDH15; cadherin 15, type 1, M-cadherin (myotubule)
hsa:9076 CLDN1; claudin 1
hsa:1365 CLDN3; claudin 3
hsa:1272 CNTN1; contactin 1
hsa:1493 CTLA4; cytotoxic T-lymphocyte-associated protein 4
hsa:2734 GLG1; golgi glycoprotein 1
hsa:3105 HLA-A; major histocompatibility complex, class I, A
hsa:3107 HLA-C; major histocompatibility complex, class I, C
hsa:3109 HLA-DMB; major histocompatibility complex, class II, DM beta
hsa:3118 HLA-DQA2; major histocompatibility complex, class II, DQ alpha 2
hsa:3134 HLA-F; major histocompatibility complex, class I, F
hsa:3135 HLA-G; major histocompatibility complex, class I, G
hsa:3383 ICAM1; intercellular adhesion molecule 1
hsa:29851 ICOS; inducible T-cell co-stimulator
hsa:3676 ITGA4; integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
hsa:3655 ITGA6; integrin, alpha 6
hsa:8516 ITGA8; integrin, alpha 8
hsa:3680 ITGA9; integrin, alpha 9
hsa:3683 ITGAL; integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
hsa:3684 ITGAM; integrin, alpha M (complement component 3 receptor 3 subunit)
hsa:3688 ITGB1; integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
hsa:3689 ITGB2; integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
hsa:3695 ITGB7; integrin, beta 7
hsa:4099 MAG; myelin associated glycoprotein
hsa:4897 NRCAM; neuronal cell adhesion molecule
hsa:9379 NRXN2; neurexin 2
hsa:100506658 OCLN; occludin (EC:2.1.1.67)
hsa:5133 PDCD1; programmed cell death 1
hsa:80380 PDCD1LG2; programmed cell death 1 ligand 2
hsa:5817 PVR; poliovirus receptor
hsa:5819 PVRL2; poliovirus receptor-related 2 (herpesvirus entry mediator B)
hsa:6382 SDC1; syndecan 1
hsa:6383 SDC2; syndecan 2
hsa:9672 SDC3; syndecan 3
hsa:6385 SDC4; syndecan 4
hsa:7412 VCAM1; vascular cell adhesion molecule 1
hsa:1462 VCAN; versican

hsa04810 Regulation of actin cytoskeleton - Homo sapiens (human) (49)



cpd:C00338 Lipopolysaccharide
hsa:60 ACTB; actin, beta
hsa:71 ACTG1; actin, gamma 1
hsa:87 ACTN1; actinin, alpha 1
hsa:10552 ARPC1A; actin related protein 2/3 complex, subunit 1A, 41kDa
hsa:10095 ARPC1B; actin related protein 2/3 complex, subunit 1B, 41kDa
hsa:10109 ARPC2; actin related protein 2/3 complex, subunit 2, 34kDa
hsa:10094 ARPC3; actin related protein 2/3 complex, subunit 3, 21kDa
hsa:10093 ARPC4; actin related protein 2/3 complex, subunit 4, 20kDa
hsa:10092 ARPC5; actin related protein 2/3 complex, subunit 5, 16kDa
hsa:81873 ARPC5L; actin related protein 2/3 complex, subunit 5-like
hsa:9564 BCAR1; breast cancer anti-estrogen resistance 1
hsa:624 BDKRB2; bradykinin receptor B2
hsa:929 CD14; CD14 molecule
hsa:1072 CFL1; cofilin 1 (non-muscle)
hsa:2258 FGF13; fibroblast growth factor 13
hsa:2252 FGF7; fibroblast growth factor 7
hsa:2335 FN1; fibronectin 1
hsa:2768 GNA12; guanine nucleotide binding protein (G protein) alpha 12
hsa:55970 GNG12; guanine nucleotide binding protein (G protein), gamma 12
hsa:3630 INS; insulin
hsa:3673 ITGA2; integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
hsa:3676 ITGA4; integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
hsa:3678 ITGA5; integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
hsa:3655 ITGA6; integrin, alpha 6
hsa:8516 ITGA8; integrin, alpha 8
hsa:3680 ITGA9; integrin, alpha 9
hsa:3683 ITGAL; integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
hsa:3684 ITGAM; integrin, alpha M (complement component 3 receptor 3 subunit)
hsa:3687 ITGAX; integrin, alpha X (complement component 3 receptor 4 subunit)
hsa:3688 ITGB1; integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
hsa:3689 ITGB2; integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
hsa:3690 ITGB3; integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
hsa:3693 ITGB5; integrin, beta 5
hsa:3695 ITGB7; integrin, beta 7
hsa:5605 MAP2K2; mitogen-activated protein kinase kinase 2 (EC:2.7.12.2)
hsa:5594 MAPK1; mitogen-activated protein kinase 1 (EC:2.7.11.24)
hsa:5595 MAPK3; mitogen-activated protein kinase 3 (EC:2.7.11.24)
hsa:4478 MSN; moesin
hsa:4628 MYH10; myosin, heavy chain 10, non-muscle
hsa:4627 MYH9; myosin, heavy chain 9, non-muscle
hsa:3071 NCKAP1L; NCK-associated protein 1-like
hsa:5154 PDGFA; platelet-derived growth factor alpha polypeptide
hsa:5155 PDGFB; platelet-derived growth factor beta polypeptide
hsa:5290 PIK3CA; phosphoinositide-3-kinase, catalytic, alpha polypeptide (EC:2.7.11.1 2.7.1.153)
hsa:5291 PIK3CB; phosphoinositide-3-kinase, catalytic, beta polypeptide (EC:2.7.1.153)
hsa:5294 PIK3CG; phosphoinositide-3-kinase, catalytic, gamma polypeptide (EC:2.7.11.1 2.7.1.153)
hsa:6237 RRAS; related RAS viral (r-ras) oncogene homolog
hsa:7414 VCL; vinculin

hsa05132 Salmonella infection - Homo sapiens (human) (47)



cpd:C00062 L-Arginine
cpd:C00338 Lipopolysaccharide
cpd:C00533 Nitric oxide
hsa:60 ACTB; actin, beta
hsa:71 ACTG1; actin, gamma 1
hsa:10552 ARPC1A; actin related protein 2/3 complex, subunit 1A, 41kDa
hsa:10095 ARPC1B; actin related protein 2/3 complex, subunit 1B, 41kDa
hsa:10109 ARPC2; actin related protein 2/3 complex, subunit 2, 34kDa
hsa:10094 ARPC3; actin related protein 2/3 complex, subunit 3, 21kDa
hsa:10093 ARPC4; actin related protein 2/3 complex, subunit 4, 20kDa
hsa:10092 ARPC5; actin related protein 2/3 complex, subunit 5, 16kDa
hsa:81873 ARPC5L; actin related protein 2/3 complex, subunit 5-like
hsa:834 CASP1; caspase 1, apoptosis-related cysteine peptidase (EC:3.4.22.36)
hsa:6348 CCL3; chemokine (C-C motif) ligand 3
hsa:6351 CCL4; chemokine (C-C motif) ligand 4
hsa:929 CD14; CD14 molecule
hsa:1437 CSF2; colony stimulating factor 2 (granulocyte-macrophage)
hsa:2919 CXCL1; chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
hsa:2920 CXCL2; chemokine (C-X-C motif) ligand 2
hsa:2921 CXCL3; chemokine (C-X-C motif) ligand 3
hsa:1781 DYNC1I2; dynein, cytoplasmic 1, intermediate chain 2
hsa:2317 FLNB; filamin B, beta
hsa:2353 FOS; FBJ murine osteosarcoma viral oncogene homolog
hsa:3458 IFNG; interferon, gamma
hsa:3459 IFNGR1; interferon gamma receptor 1
hsa:3460 IFNGR2; interferon gamma receptor 2 (interferon gamma transducer 1)
hsa:3606 IL18; interleukin 18 (interferon-gamma-inducing factor)
hsa:3552 IL1A; interleukin 1, alpha
hsa:3553 IL1B; interleukin 1, beta
hsa:3569 IL6; interleukin 6 (interferon, beta 2)
hsa:3576 IL8; interleukin 8
hsa:3725 JUN; jun proto-oncogene
hsa:5594 MAPK1; mitogen-activated protein kinase 1 (EC:2.7.11.24)
hsa:1432 MAPK14; mitogen-activated protein kinase 14 (EC:2.7.11.24)
hsa:5595 MAPK3; mitogen-activated protein kinase 3 (EC:2.7.11.24)
hsa:5601 MAPK9; mitogen-activated protein kinase 9 (EC:2.7.11.24)
hsa:4615 MYD88; myeloid differentiation primary response gene (88)
hsa:4628 MYH10; myosin, heavy chain 10, non-muscle
hsa:4627 MYH9; myosin, heavy chain 9, non-muscle
hsa:4790 NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
hsa:4843 NOS2; nitric oxide synthase 2, inducible (EC:1.14.13.39)
hsa:5585 PKN1; protein kinase N1 (EC:2.7.11.13)
hsa:29941 PKN3; protein kinase N3 (EC:2.7.11.13)
hsa:5970 RELA; v-rel reticuloendotheliosis viral oncogene homolog A (avian)
hsa:391 RHOG; ras homolog family member G
hsa:7082 TJP1; tight junction protein 1 (zona occludens 1)
hsa:7099 TLR4; toll-like receptor 4

hsa04145 Phagosome - Homo sapiens (human) (47)



cpd:C00027 Hydrogen peroxide
cpd:C00533 Nitric oxide
hsa:60 ACTB; actin, beta
hsa:71 ACTG1; actin, gamma 1
hsa:535 ATP6V0A1; ATPase, H+ transporting, lysosomal V0 subunit a1 (EC:3.6.3.14)
hsa:533 ATP6V0B; ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b (EC:3.6.3.14)
hsa:245972 ATP6V0D2; ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2 (EC:3.6.3.14)
hsa:523 ATP6V1A; ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A (EC:3.6.3.14)
hsa:715 C1R; complement component 1, r subcomponent (EC:3.4.21.41)
hsa:718 C3; complement component 3 (EC:3.4.21.43)
hsa:811 CALR; calreticulin
hsa:821 CANX; calnexin
hsa:929 CD14; CD14 molecule
hsa:948 CD36; CD36 molecule (thrombospondin receptor)
hsa:81035 COLEC12; collectin sub-family member 12
hsa:1536 CYBB; cytochrome b-245, beta polypeptide
hsa:1781 DYNC1I2; dynein, cytoplasmic 1, intermediate chain 2
hsa:2209 FCGR1A; Fc fragment of IgG, high affinity Ia, receptor (CD64)
hsa:2213 FCGR2B; Fc fragment of IgG, low affinity IIb, receptor (CD32)
hsa:2214 FCGR3A; Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
hsa:2215 FCGR3B; Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
hsa:3105 HLA-A; major histocompatibility complex, class I, A
hsa:3107 HLA-C; major histocompatibility complex, class I, C
hsa:3109 HLA-DMB; major histocompatibility complex, class II, DM beta
hsa:3118 HLA-DQA2; major histocompatibility complex, class II, DQ alpha 2
hsa:3134 HLA-F; major histocompatibility complex, class I, F
hsa:3135 HLA-G; major histocompatibility complex, class I, G
hsa:3673 ITGA2; integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
hsa:3678 ITGA5; integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
hsa:3684 ITGAM; integrin, alpha M (complement component 3 receptor 3 subunit)
hsa:3688 ITGB1; integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
hsa:3689 ITGB2; integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
hsa:3690 ITGB3; integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
hsa:3693 ITGB5; integrin, beta 5
hsa:3916 LAMP1; lysosomal-associated membrane protein 1
hsa:4842 NOS1; nitric oxide synthase 1 (neuronal) (EC:1.14.13.39)
hsa:27035 NOX1; NADPH oxidase 1
hsa:4973 OLR1; oxidized low density lipoprotein (lectin-like) receptor 1
hsa:5289 PIK3C3; phosphoinositide-3-kinase, class 3 (EC:2.7.1.137)
hsa:5869 RAB5B; RAB5B, member RAS oncogene family
hsa:6890 TAP1; transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
hsa:6891 TAP2; transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
hsa:7037 TFRC; transferrin receptor (p90, CD71)
hsa:7057 THBS1; thrombospondin 1
hsa:7097 TLR2; toll-like receptor 2
hsa:7099 TLR4; toll-like receptor 4
hsa:81027 TUBB1; tubulin, beta 1 class VI

hsa04650 Natural killer cell mediated cytotoxicity - Homo sapiens (human) (46)



cpd:C00165 Diacylglycerol
hsa:637 BID; BH3 interacting domain death agonist
hsa:836 CASP3; caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56)
hsa:1437 CSF2; colony stimulating factor 2 (granulocyte-macrophage)
hsa:355 FAS; Fas (TNF receptor superfamily, member 6)
hsa:2214 FCGR3A; Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
hsa:2215 FCGR3B; Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
hsa:2534 FYN; FYN oncogene related to SRC, FGR, YES (EC:2.7.10.2)
hsa:3002 GZMB; granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) (EC:3.4.21.79)
hsa:3105 HLA-A; major histocompatibility complex, class I, A
hsa:3107 HLA-C; major histocompatibility complex, class I, C
hsa:3135 HLA-G; major histocompatibility complex, class I, G
hsa:3383 ICAM1; intercellular adhesion molecule 1
hsa:3439 IFNA1; interferon, alpha 1
hsa:3443 IFNA6; interferon, alpha 6
hsa:3458 IFNG; interferon, gamma
hsa:3459 IFNGR1; interferon gamma receptor 1
hsa:3460 IFNGR2; interferon gamma receptor 2 (interferon gamma transducer 1)
hsa:3683 ITGAL; integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
hsa:3689 ITGB2; integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
hsa:3824 KLRD1; killer cell lectin-like receptor subfamily D, member 1
hsa:22914 KLRK1; killer cell lectin-like receptor subfamily K, member 1
hsa:3932 LCK; lymphocyte-specific protein tyrosine kinase (EC:2.7.10.2)
hsa:5605 MAP2K2; mitogen-activated protein kinase kinase 2 (EC:2.7.12.2)
hsa:5594 MAPK1; mitogen-activated protein kinase 1 (EC:2.7.11.24)
hsa:5595 MAPK3; mitogen-activated protein kinase 3 (EC:2.7.11.24)
hsa:4772 NFATC1; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
hsa:5290 PIK3CA; phosphoinositide-3-kinase, catalytic, alpha polypeptide (EC:2.7.11.1 2.7.1.153)
hsa:5291 PIK3CB; phosphoinositide-3-kinase, catalytic, beta polypeptide (EC:2.7.1.153)
hsa:5294 PIK3CG; phosphoinositide-3-kinase, catalytic, gamma polypeptide (EC:2.7.11.1 2.7.1.153)
hsa:5335 PLCG1; phospholipase C, gamma 1 (EC:3.1.4.11)
hsa:5530 PPP3CA; protein phosphatase 3, catalytic subunit, alpha isozyme (EC:3.1.3.16)
hsa:5532 PPP3CB; protein phosphatase 3, catalytic subunit, beta isozyme (EC:3.1.3.16)
hsa:5533 PPP3CC; protein phosphatase 3, catalytic subunit, gamma isozyme (EC:3.1.3.16)
hsa:5534 PPP3R1; protein phosphatase 3, regulatory subunit B, alpha (EC:3.1.3.16)
hsa:5535 PPP3R2; protein phosphatase 3, regulatory subunit B, beta (EC:3.1.3.16)
hsa:5551 PRF1; perforin 1 (pore forming protein)
hsa:5578 PRKCA; protein kinase C, alpha (EC:2.7.11.13)
hsa:5579 PRKCB; protein kinase C, beta (EC:2.7.11.13)
hsa:2185 PTK2B; PTK2B protein tyrosine kinase 2 beta (EC:2.7.10.2)
hsa:5781 PTPN11; protein tyrosine phosphatase, non-receptor type 11 (EC:3.1.3.48)
hsa:6452 SH3BP2; SH3-domain binding protein 2
hsa:7124 TNF; tumor necrosis factor
hsa:8743 TNFSF10; tumor necrosis factor (ligand) superfamily, member 10
hsa:80329 ULBP1; UL16 binding protein 1
hsa:79465 ULBP3; UL16 binding protein 3

hsa04210 Apoptosis - Homo sapiens (human) (45)



hsa:9131 AIFM1; apoptosis-inducing factor, mitochondrion-associated, 1
hsa:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1)
hsa:317 APAF1; apoptotic peptidase activating factor 1
hsa:472 ATM; ataxia telangiectasia mutated (EC:2.7.11.1)
hsa:572 BAD; BCL2-associated agonist of cell death
hsa:581 BAX; BCL2-associated X protein
hsa:596 BCL2; B-cell CLL/lymphoma 2
hsa:637 BID; BH3 interacting domain death agonist
hsa:329 BIRC2; baculoviral IAP repeat containing 2
hsa:330 BIRC3; baculoviral IAP repeat containing 3
hsa:823 CAPN1; calpain 1, (mu/I) large subunit (EC:3.4.22.52)
hsa:824 CAPN2; calpain 2, (m/II) large subunit (EC:3.4.22.53)
hsa:836 CASP3; caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56)
hsa:840 CASP7; caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60)
hsa:841 CASP8; caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61)
hsa:842 CASP9; caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62)
hsa:8837 CFLAR; CASP8 and FADD-like apoptosis regulator
hsa:1147 CHUK; conserved helix-loop-helix ubiquitous kinase (EC:2.7.11.10)
hsa:1439 CSF2RB; colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
hsa:54205 CYCS; cytochrome c, somatic
hsa:8772 FADD; Fas (TNFRSF6)-associated via death domain
hsa:355 FAS; Fas (TNF receptor superfamily, member 6)
hsa:3552 IL1A; interleukin 1, alpha
hsa:3553 IL1B; interleukin 1, beta
hsa:3562 IL3; interleukin 3 (colony-stimulating factor, multiple)
hsa:3563 IL3RA; interleukin 3 receptor, alpha (low affinity)
hsa:51135 IRAK4; interleukin-1 receptor-associated kinase 4 (EC:2.7.11.1)
hsa:9020 MAP3K14; mitogen-activated protein kinase kinase kinase 14 (EC:2.7.11.25)
hsa:4615 MYD88; myeloid differentiation primary response gene (88)
hsa:4790 NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
hsa:4792 NFKBIA; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
hsa:5290 PIK3CA; phosphoinositide-3-kinase, catalytic, alpha polypeptide (EC:2.7.11.1 2.7.1.153)
hsa:5291 PIK3CB; phosphoinositide-3-kinase, catalytic, beta polypeptide (EC:2.7.1.153)
hsa:5294 PIK3CG; phosphoinositide-3-kinase, catalytic, gamma polypeptide (EC:2.7.11.1 2.7.1.153)
hsa:5530 PPP3CA; protein phosphatase 3, catalytic subunit, alpha isozyme (EC:3.1.3.16)
hsa:5532 PPP3CB; protein phosphatase 3, catalytic subunit, beta isozyme (EC:3.1.3.16)
hsa:5533 PPP3CC; protein phosphatase 3, catalytic subunit, gamma isozyme (EC:3.1.3.16)
hsa:5534 PPP3R1; protein phosphatase 3, regulatory subunit B, alpha (EC:3.1.3.16)
hsa:5535 PPP3R2; protein phosphatase 3, regulatory subunit B, beta (EC:3.1.3.16)
hsa:5575 PRKAR1B; protein kinase, cAMP-dependent, regulatory, type I, beta (EC:2.7.11.1)
hsa:5970 RELA; v-rel reticuloendotheliosis viral oncogene homolog A (avian)
hsa:7124 TNF; tumor necrosis factor
hsa:7132 TNFRSF1A; tumor necrosis factor receptor superfamily, member 1A
hsa:8743 TNFSF10; tumor necrosis factor (ligand) superfamily, member 10
hsa:8717 TRADD; TNFRSF1A-associated via death domain

hsa05322 Systemic lupus erythematosus - Homo sapiens (human) (45)



cpd:C00027 Hydrogen peroxide
cpd:C02737 Phosphatidylserine
hsa:87 ACTN1; actinin, alpha 1
hsa:712 C1QA; complement component 1, q subcomponent, A chain
hsa:714 C1QC; complement component 1, q subcomponent, C chain
hsa:715 C1R; complement component 1, r subcomponent (EC:3.4.21.41)
hsa:716 C1S; complement component 1, s subcomponent (EC:3.4.21.42)
hsa:718 C3; complement component 3 (EC:3.4.21.43)
hsa:720 C4A; complement component 4A (Rodgers blood group)
hsa:721 C4B; complement component 4B (Chido blood group)
hsa:727 C5; complement component 5
hsa:729 C6; complement component 6
hsa:730 C7; complement component 7
hsa:731 C8A; complement component 8, alpha polypeptide
hsa:732 C8B; complement component 8, beta polypeptide
hsa:940 CD28; CD28 molecule
hsa:958 CD40; CD40 molecule, TNF receptor superfamily member 5
hsa:959 CD40LG; CD40 ligand
hsa:941 CD80; CD80 molecule
hsa:942 CD86; CD86 molecule
hsa:1991 ELANE; elastase, neutrophil expressed (EC:3.4.21.37)
hsa:2209 FCGR1A; Fc fragment of IgG, high affinity Ia, receptor (CD64)
hsa:2213 FCGR2B; Fc fragment of IgG, low affinity IIb, receptor (CD32)
hsa:2214 FCGR3A; Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
hsa:2215 FCGR3B; Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
hsa:2903 GRIN2A; glutamate receptor, ionotropic, N-methyl D-aspartate 2A
hsa:3014 H2AFX; H2A histone family, member X
hsa:8335 HIST1H2AB; histone cluster 1, H2ab
hsa:8332 HIST1H2AL; histone cluster 1, H2al
hsa:8347 HIST1H2BC; histone cluster 1, H2bc
hsa:8344 HIST1H2BE; histone cluster 1, H2be
hsa:8350 HIST1H3A; histone cluster 1, H3a
hsa:8352 HIST1H3C; histone cluster 1, H3c
hsa:8357 HIST1H3H; histone cluster 1, H3h
hsa:8356 HIST1H3J; histone cluster 1, H3j
hsa:8294 HIST1H4I; histone cluster 1, H4i
hsa:8337 HIST2H2AA3; histone cluster 2, H2aa3
hsa:8370 HIST2H4A; histone cluster 2, H4a
hsa:3109 HLA-DMB; major histocompatibility complex, class II, DM beta
hsa:3118 HLA-DQA2; major histocompatibility complex, class II, DQ alpha 2
hsa:3458 IFNG; interferon, gamma
hsa:3586 IL10; interleukin 10
hsa:6741 SSB; Sjogren syndrome antigen B (autoantigen La)
hsa:7124 TNF; tumor necrosis factor
hsa:6737 TRIM21; tripartite motif containing 21

hsa04660 T cell receptor signaling pathway - Homo sapiens (human) (45)



cpd:C00165 Diacylglycerol
hsa:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1)
hsa:940 CD28; CD28 molecule
hsa:920 CD4; CD4 molecule
hsa:959 CD40LG; CD40 ligand
hsa:1147 CHUK; conserved helix-loop-helix ubiquitous kinase (EC:2.7.11.10)
hsa:1437 CSF2; colony stimulating factor 2 (granulocyte-macrophage)
hsa:1493 CTLA4; cytotoxic T-lymphocyte-associated protein 4
hsa:2353 FOS; FBJ murine osteosarcoma viral oncogene homolog
hsa:2534 FYN; FYN oncogene related to SRC, FGR, YES (EC:2.7.10.2)
hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26)
hsa:29851 ICOS; inducible T-cell co-stimulator
hsa:3458 IFNG; interferon, gamma
hsa:3586 IL10; interleukin 10
hsa:3558 IL2; interleukin 2
hsa:3565 IL4; interleukin 4
hsa:3567 IL5; interleukin 5 (colony-stimulating factor, eosinophil)
hsa:3725 JUN; jun proto-oncogene
hsa:3932 LCK; lymphocyte-specific protein tyrosine kinase (EC:2.7.10.2)
hsa:5605 MAP2K2; mitogen-activated protein kinase kinase 2 (EC:2.7.12.2)
hsa:9020 MAP3K14; mitogen-activated protein kinase kinase kinase 14 (EC:2.7.11.25)
hsa:6885 MAP3K7; mitogen-activated protein kinase kinase kinase 7 (EC:2.7.11.25)
hsa:1326 MAP3K8; mitogen-activated protein kinase kinase kinase 8 (EC:2.7.11.25)
hsa:5594 MAPK1; mitogen-activated protein kinase 1 (EC:2.7.11.24)
hsa:1432 MAPK14; mitogen-activated protein kinase 14 (EC:2.7.11.24)
hsa:5595 MAPK3; mitogen-activated protein kinase 3 (EC:2.7.11.24)
hsa:5601 MAPK9; mitogen-activated protein kinase 9 (EC:2.7.11.24)
hsa:4772 NFATC1; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
hsa:4790 NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
hsa:4792 NFKBIA; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
hsa:4793 NFKBIB; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
hsa:5133 PDCD1; programmed cell death 1
hsa:5163 PDK1; pyruvate dehydrogenase kinase, isozyme 1 (EC:2.7.11.2)
hsa:5290 PIK3CA; phosphoinositide-3-kinase, catalytic, alpha polypeptide (EC:2.7.11.1 2.7.1.153)
hsa:5291 PIK3CB; phosphoinositide-3-kinase, catalytic, beta polypeptide (EC:2.7.1.153)
hsa:5294 PIK3CG; phosphoinositide-3-kinase, catalytic, gamma polypeptide (EC:2.7.11.1 2.7.1.153)
hsa:5335 PLCG1; phospholipase C, gamma 1 (EC:3.1.4.11)
hsa:5530 PPP3CA; protein phosphatase 3, catalytic subunit, alpha isozyme (EC:3.1.3.16)
hsa:5532 PPP3CB; protein phosphatase 3, catalytic subunit, beta isozyme (EC:3.1.3.16)
hsa:5533 PPP3CC; protein phosphatase 3, catalytic subunit, gamma isozyme (EC:3.1.3.16)
hsa:5534 PPP3R1; protein phosphatase 3, regulatory subunit B, alpha (EC:3.1.3.16)
hsa:5535 PPP3R2; protein phosphatase 3, regulatory subunit B, beta (EC:3.1.3.16)
hsa:5970 RELA; v-rel reticuloendotheliosis viral oncogene homolog A (avian)
hsa:7006 TEC; tec protein tyrosine kinase (EC:2.7.10.2)
hsa:7124 TNF; tumor necrosis factor

hsa05323 Rheumatoid arthritis - Homo sapiens (human) (44)



cpd:C00584 Prostaglandin E2
hsa:535 ATP6V0A1; ATPase, H+ transporting, lysosomal V0 subunit a1 (EC:3.6.3.14)
hsa:533 ATP6V0B; ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b (EC:3.6.3.14)
hsa:245972 ATP6V0D2; ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2 (EC:3.6.3.14)
hsa:523 ATP6V1A; ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A (EC:3.6.3.14)
hsa:6347 CCL2; chemokine (C-C motif) ligand 2
hsa:6364 CCL20; chemokine (C-C motif) ligand 20
hsa:6348 CCL3; chemokine (C-C motif) ligand 3
hsa:6352 CCL5; chemokine (C-C motif) ligand 5
hsa:940 CD28; CD28 molecule
hsa:941 CD80; CD80 molecule
hsa:942 CD86; CD86 molecule
hsa:1435 CSF1; colony stimulating factor 1 (macrophage) (EC:2.7.10.1)
hsa:1437 CSF2; colony stimulating factor 2 (granulocyte-macrophage)
hsa:1493 CTLA4; cytotoxic T-lymphocyte-associated protein 4
hsa:2919 CXCL1; chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
hsa:6387 CXCL12; chemokine (C-X-C motif) ligand 12
hsa:6374 CXCL5; chemokine (C-X-C motif) ligand 5
hsa:2321 FLT1; fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) (EC:2.7.10.1)
hsa:2353 FOS; FBJ murine osteosarcoma viral oncogene homolog
hsa:3109 HLA-DMB; major histocompatibility complex, class II, DM beta
hsa:3118 HLA-DQA2; major histocompatibility complex, class II, DQ alpha 2
hsa:3383 ICAM1; intercellular adhesion molecule 1
hsa:3458 IFNG; interferon, gamma
hsa:3589 IL11; interleukin 11
hsa:3600 IL15; interleukin 15
hsa:3605 IL17A; interleukin 17A
hsa:3606 IL18; interleukin 18 (interferon-gamma-inducing factor)
hsa:3552 IL1A; interleukin 1, alpha
hsa:3553 IL1B; interleukin 1, beta
hsa:3569 IL6; interleukin 6 (interferon, beta 2)
hsa:3576 IL8; interleukin 8
hsa:3683 ITGAL; integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
hsa:3689 ITGB2; integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
hsa:3725 JUN; jun proto-oncogene
hsa:4050 LTB; lymphotoxin beta (TNF superfamily, member 3)
hsa:4312 MMP1; matrix metallopeptidase 1 (interstitial collagenase) (EC:3.4.24.7)
hsa:4314 MMP3; matrix metallopeptidase 3 (stromelysin 1, progelatinase) (EC:3.4.24.17)
hsa:5228 PGF; placental growth factor
hsa:7040 TGFB1; transforming growth factor, beta 1
hsa:7097 TLR2; toll-like receptor 2
hsa:7099 TLR4; toll-like receptor 4
hsa:7124 TNF; tumor necrosis factor
hsa:8792 TNFRSF11A; tumor necrosis factor receptor superfamily, member 11a, NFKB activator

hsa04020 Calcium signaling pathway - Homo sapiens (human) (44)



cpd:C00002 ATP
cpd:C00165 Diacylglycerol
cpd:C00575 3',5'-Cyclic AMP
cpd:C13050 Cyclic ADP-ribose
hsa:109 ADCY3; adenylate cyclase 3 (EC:4.6.1.1)
hsa:148 ADRA1A; adrenergic, alpha-1A-, receptor
hsa:155 ADRB3; adrenergic, beta-3-, receptor
hsa:493 ATP2B4; ATPase, Ca++ transporting, plasma membrane 4 (EC:3.6.3.8)
hsa:624 BDKRB2; bradykinin receptor B2
hsa:683 BST1; bone marrow stromal cell antigen 1 (EC:3.2.2.5)
hsa:8913 CACNA1G; calcium channel, voltage-dependent, T type, alpha 1G subunit
hsa:805 CALM2; calmodulin 2 (phosphorylase kinase, delta) (EC:2.7.11.19)
hsa:808 CALM3; calmodulin 3 (phosphorylase kinase, delta) (EC:2.7.11.19)
hsa:952 CD38; CD38 molecule (EC:3.2.2.5)
hsa:1812 DRD1; dopamine receptor D1
hsa:1816 DRD5; dopamine receptor D5
hsa:1910 EDNRB; endothelin receptor type B
hsa:2064 ERBB2; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) (EC:2.7.10.1)
hsa:2903 GRIN2A; glutamate receptor, ionotropic, N-methyl D-aspartate 2A
hsa:3706 ITPKA; inositol-trisphosphate 3-kinase A (EC:2.7.1.127)
hsa:3708 ITPR1; inositol 1,4,5-trisphosphate receptor, type 1
hsa:56413 LTB4R2; leukotriene B4 receptor 2
hsa:4842 NOS1; nitric oxide synthase 1 (neuronal) (EC:1.14.13.39)
hsa:4843 NOS2; nitric oxide synthase 2, inducible (EC:1.14.13.39)
hsa:9127 P2RX6; purinergic receptor P2X, ligand-gated ion channel, 6
hsa:5027 P2RX7; purinergic receptor P2X, ligand-gated ion channel, 7
hsa:5137 PDE1C; phosphodiesterase 1C, calmodulin-dependent 70kDa (EC:3.1.4.17)
hsa:5257 PHKB; phosphorylase kinase, beta (EC:2.7.11.19 2.7.1.38)
hsa:5330 PLCB2; phospholipase C, beta 2 (EC:3.1.4.11)
hsa:5331 PLCB3; phospholipase C, beta 3 (phosphatidylinositol-specific) (EC:3.1.4.11)
hsa:5335 PLCG1; phospholipase C, gamma 1 (EC:3.1.4.11)
hsa:5350 PLN; phospholamban
hsa:10105 PPIF; peptidylprolyl isomerase F (EC:5.2.1.8)
hsa:5530 PPP3CA; protein phosphatase 3, catalytic subunit, alpha isozyme (EC:3.1.3.16)
hsa:5532 PPP3CB; protein phosphatase 3, catalytic subunit, beta isozyme (EC:3.1.3.16)
hsa:5533 PPP3CC; protein phosphatase 3, catalytic subunit, gamma isozyme (EC:3.1.3.16)
hsa:5534 PPP3R1; protein phosphatase 3, regulatory subunit B, alpha (EC:3.1.3.16)
hsa:5535 PPP3R2; protein phosphatase 3, regulatory subunit B, beta (EC:3.1.3.16)
hsa:5578 PRKCA; protein kinase C, alpha (EC:2.7.11.13)
hsa:5579 PRKCB; protein kinase C, beta (EC:2.7.11.13)
hsa:5724 PTAFR; platelet-activating factor receptor
hsa:2185 PTK2B; PTK2B protein tyrosine kinase 2 beta (EC:2.7.10.2)
hsa:6870 TACR3; tachykinin receptor 3
hsa:7416 VDAC1; voltage-dependent anion channel 1

hsa04640 Hematopoietic cell lineage - Homo sapiens (human) (42)



hsa:929 CD14; CD14 molecule
hsa:912 CD1D; CD1d molecule
hsa:914 CD2; CD2 molecule
hsa:933 CD22; CD22 molecule
hsa:100133941 CD24; CD24 molecule
hsa:945 CD33; CD33 molecule
hsa:948 CD36; CD36 molecule (thrombospondin receptor)
hsa:952 CD38; CD38 molecule (EC:3.2.2.5)
hsa:920 CD4; CD4 molecule
hsa:960 CD44; CD44 molecule (Indian blood group)
hsa:1604 CD55; CD55 molecule, decay accelerating factor for complement (Cromer blood group)
hsa:966 CD59; CD59 molecule, complement regulatory protein
hsa:928 CD9; CD9 molecule
hsa:1378 CR1; complement component (3b/4b) receptor 1 (Knops blood group)
hsa:1435 CSF1; colony stimulating factor 1 (macrophage) (EC:2.7.10.1)
hsa:1437 CSF2; colony stimulating factor 2 (granulocyte-macrophage)
hsa:1440 CSF3; colony stimulating factor 3 (granulocyte)
hsa:2208 FCER2; Fc fragment of IgE, low affinity II, receptor for (CD23)
hsa:2209 FCGR1A; Fc fragment of IgG, high affinity Ia, receptor (CD64)
hsa:2811 GP1BA; glycoprotein Ib (platelet), alpha polypeptide
hsa:3589 IL11; interleukin 11
hsa:3590 IL11RA; interleukin 11 receptor, alpha
hsa:3552 IL1A; interleukin 1, alpha
hsa:3553 IL1B; interleukin 1, beta
hsa:3559 IL2RA; interleukin 2 receptor, alpha
hsa:3562 IL3; interleukin 3 (colony-stimulating factor, multiple)
hsa:3563 IL3RA; interleukin 3 receptor, alpha (low affinity)
hsa:3565 IL4; interleukin 4
hsa:3566 IL4R; interleukin 4 receptor
hsa:3567 IL5; interleukin 5 (colony-stimulating factor, eosinophil)
hsa:3569 IL6; interleukin 6 (interferon, beta 2)
hsa:3574 IL7; interleukin 7
hsa:3575 IL7R; interleukin 7 receptor
hsa:3673 ITGA2; integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
hsa:3676 ITGA4; integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
hsa:3678 ITGA5; integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
hsa:3655 ITGA6; integrin, alpha 6
hsa:3684 ITGAM; integrin, alpha M (complement component 3 receptor 3 subunit)
hsa:3690 ITGB3; integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
hsa:4254 KITLG; KIT ligand
hsa:7037 TFRC; transferrin receptor (p90, CD71)
hsa:7124 TNF; tumor necrosis factor

hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human) (42)



cpd:C00002 ATP
cpd:C00212 Adenosine
cpd:C00547 L-Noradrenaline
cpd:C00584 Prostaglandin E2
cpd:C01598 Melatonin
cpd:C01829 Thyroxine
cpd:C02165 Leukotriene B4
cpd:C02166 Leukotriene C4
cpd:C03758 Dopamine
cpd:C04598 2-Acetyl-1-alkyl-sn-glycero-3-phosphocholine
cpd:C05951 Leukotriene D4
cpd:C06314 Lipoxin A4
hsa:134 ADORA1; adenosine A1 receptor
hsa:148 ADRA1A; adrenergic, alpha-1A-, receptor
hsa:155 ADRB3; adrenergic, beta-3-, receptor
hsa:624 BDKRB2; bradykinin receptor B2
hsa:728 C5AR1; complement component 5a receptor 1
hsa:1812 DRD1; dopamine receptor D1
hsa:1813 DRD2; dopamine receptor D2
hsa:1814 DRD3; dopamine receptor D3
hsa:1815 DRD4; dopamine receptor D4
hsa:1816 DRD5; dopamine receptor D5
hsa:1910 EDNRB; endothelin receptor type B
hsa:2358 FPR2; formyl peptide receptor 2
hsa:2562 GABRB3; gamma-aminobutyric acid (GABA) A receptor, beta 3
hsa:2903 GRIN2A; glutamate receptor, ionotropic, N-methyl D-aspartate 2A
hsa:3352 HTR1D; 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled
hsa:56413 LTB4R2; leukotriene B4 receptor 2
hsa:9127 P2RX6; purinergic receptor P2X, ligand-gated ion channel, 6
hsa:5027 P2RX7; purinergic receptor P2X, ligand-gated ion channel, 7
hsa:5028 P2RY1; purinergic receptor P2Y, G-protein coupled, 1
hsa:9934 P2RY14; purinergic receptor P2Y, G-protein coupled, 14
hsa:5029 P2RY2; purinergic receptor P2Y, G-protein coupled, 2
hsa:5617 PRL; prolactin
hsa:2834 PRLHR; prolactin releasing hormone receptor
hsa:5644 PRSS1; protease, serine, 1 (trypsin 1) (EC:3.4.21.4)
hsa:5724 PTAFR; platelet-activating factor receptor
hsa:5734 PTGER4; prostaglandin E receptor 4 (subtype EP4)
hsa:1901 S1PR1; sphingosine-1-phosphate receptor 1
hsa:6870 TACR3; tachykinin receptor 3
hsa:706 TSPO; translocator protein (18kDa)
hsa:7434 VIPR2; vasoactive intestinal peptide receptor 2

hsa04144 Endocytosis - Homo sapiens (human) (42)



cpd:C00002 ATP
cpd:C00504 Folate
hsa:155 ADRB3; adrenergic, beta-3-, receptor
hsa:116987 AGAP1; ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
hsa:160 AP2A1; adaptor-related protein complex 2, alpha 1 subunit
hsa:382 ARF6; ADP-ribosylation factor 6
hsa:857 CAV1; caveolin 1, caveolae protein, 22kDa
hsa:858 CAV2; caveolin 2
hsa:1234 CCR5; chemokine (C-C motif) receptor 5 (gene/pseudogene)
hsa:27243 CHMP2A; charged multivesicular body protein 2A
hsa:92421 CHMP4C; charged multivesicular body protein 4C
hsa:1211 CLTA; clathrin, light chain A
hsa:3579 CXCR2; chemokine (C-X-C motif) receptor 2
hsa:7852 CXCR4; chemokine (C-X-C motif) receptor 4
hsa:1601 DAB2; disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
hsa:1759 DNM1; dynamin 1 (EC:3.6.5.5)
hsa:22905 EPN2; epsin 2
hsa:2321 FLT1; fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) (EC:2.7.10.1)
hsa:2350 FOLR2; folate receptor 2 (fetal)
hsa:2869 GRK5; G protein-coupled receptor kinase 5 (EC:2.7.11.16)
hsa:3105 HLA-A; major histocompatibility complex, class I, A
hsa:3107 HLA-C; major histocompatibility complex, class I, C
hsa:3134 HLA-F; major histocompatibility complex, class I, F
hsa:3135 HLA-G; major histocompatibility complex, class I, G
hsa:3312 HSPA8; heat shock 70kDa protein 8
hsa:3559 IL2RA; interleukin 2 receptor, alpha
hsa:3560 IL2RB; interleukin 2 receptor, beta
hsa:3561 IL2RG; interleukin 2 receptor, gamma
hsa:3949 LDLR; low density lipoprotein receptor
hsa:4734 NEDD4; neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase (EC:6.3.2.-)
hsa:84552 PARD6G; par-6 partitioning defective 6 homolog gamma (C. elegans)
hsa:5337 PLD1; phospholipase D1, phosphatidylcholine-specific (EC:3.1.4.4)
hsa:5371 PML; promyelocytic leukemia
hsa:26056 RAB11FIP5; RAB11 family interacting protein 5 (class I)
hsa:5869 RAB5B; RAB5B, member RAS oncogene family
hsa:4087 SMAD2; SMAD family member 2
hsa:7037 TFRC; transferrin receptor (p90, CD71)
hsa:7040 TGFB1; transforming growth factor, beta 1
hsa:7046 TGFBR1; transforming growth factor, beta receptor 1 (EC:2.7.11.30)
hsa:7189 TRAF6; TNF receptor-associated factor 6, E3 ubiquitin protein ligase
hsa:51160 VPS28; vacuolar protein sorting 28 homolog (S. cerevisiae)
hsa:11059 WWP1; WW domain containing E3 ubiquitin protein ligase 1

hsa05034 Alcoholism - Homo sapiens (human) (40)



cpd:C00027 Hydrogen peroxide
cpd:C00212 Adenosine
cpd:C00355 3,4-Dihydroxy-L-phenylalanine
cpd:C00575 3',5'-Cyclic AMP
cpd:C03758 Dopamine
hsa:1388 ATF6B; activating transcription factor 6 beta
hsa:805 CALM2; calmodulin 2 (phosphorylase kinase, delta) (EC:2.7.11.19)
hsa:808 CALM3; calmodulin 3 (phosphorylase kinase, delta) (EC:2.7.11.19)
hsa:1385 CREB1; cAMP responsive element binding protein 1
hsa:10488 CREB3; cAMP responsive element binding protein 3
hsa:9586 CREB5; cAMP responsive element binding protein 5
hsa:1644 DDC; dopa decarboxylase (aromatic L-amino acid decarboxylase) (EC:4.1.1.28)
hsa:1812 DRD1; dopamine receptor D1
hsa:1813 DRD2; dopamine receptor D2
hsa:59345 GNB4; guanine nucleotide binding protein (G protein), beta polypeptide 4
hsa:55970 GNG12; guanine nucleotide binding protein (G protein), gamma 12
hsa:2793 GNGT2; guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2
hsa:2903 GRIN2A; glutamate receptor, ionotropic, N-methyl D-aspartate 2A
hsa:3014 H2AFX; H2A histone family, member X
hsa:10014 HDAC5; histone deacetylase 5 (EC:3.5.1.98)
hsa:10013 HDAC6; histone deacetylase 6 (EC:3.5.1.98)
hsa:9734 HDAC9; histone deacetylase 9 (EC:3.5.1.98)
hsa:8335 HIST1H2AB; histone cluster 1, H2ab
hsa:8332 HIST1H2AL; histone cluster 1, H2al
hsa:8347 HIST1H2BC; histone cluster 1, H2bc
hsa:8344 HIST1H2BE; histone cluster 1, H2be
hsa:8350 HIST1H3A; histone cluster 1, H3a
hsa:8352 HIST1H3C; histone cluster 1, H3c
hsa:8357 HIST1H3H; histone cluster 1, H3h
hsa:8356 HIST1H3J; histone cluster 1, H3j
hsa:8294 HIST1H4I; histone cluster 1, H4i
hsa:8337 HIST2H2AA3; histone cluster 2, H2aa3
hsa:8370 HIST2H4A; histone cluster 2, H4a
hsa:4128 MAOA; monoamine oxidase A (EC:1.4.3.4)
hsa:5594 MAPK1; mitogen-activated protein kinase 1 (EC:2.7.11.24)
hsa:5595 MAPK3; mitogen-activated protein kinase 3 (EC:2.7.11.24)
hsa:4852 NPY; neuropeptide Y
hsa:5173 PDYN; prodynorphin
hsa:6531 SLC6A3; solute carrier family 6 (neurotransmitter transporter, dopamine), member 3
hsa:7054 TH; tyrosine hydroxylase (EC:1.14.16.2)

hsa04728 Dopaminergic synapse - Homo sapiens (human) (39)



cpd:C00165 Diacylglycerol
cpd:C00238 Potassium cation
cpd:C00355 3,4-Dihydroxy-L-phenylalanine
cpd:C00575 3',5'-Cyclic AMP
cpd:C03758 Dopamine
cpd:C05582 Homovanillate
hsa:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1)
hsa:1388 ATF6B; activating transcription factor 6 beta
hsa:805 CALM2; calmodulin 2 (phosphorylase kinase, delta) (EC:2.7.11.19)
hsa:808 CALM3; calmodulin 3 (phosphorylase kinase, delta) (EC:2.7.11.19)
hsa:1385 CREB1; cAMP responsive element binding protein 1
hsa:10488 CREB3; cAMP responsive element binding protein 3
hsa:9586 CREB5; cAMP responsive element binding protein 5
hsa:1644 DDC; dopa decarboxylase (aromatic L-amino acid decarboxylase) (EC:4.1.1.28)
hsa:1812 DRD1; dopamine receptor D1
hsa:1813 DRD2; dopamine receptor D2
hsa:1814 DRD3; dopamine receptor D3
hsa:1815 DRD4; dopamine receptor D4
hsa:1816 DRD5; dopamine receptor D5
hsa:2353 FOS; FBJ murine osteosarcoma viral oncogene homolog
hsa:59345 GNB4; guanine nucleotide binding protein (G protein), beta polypeptide 4
hsa:55970 GNG12; guanine nucleotide binding protein (G protein), gamma 12
hsa:2793 GNGT2; guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2
hsa:2903 GRIN2A; glutamate receptor, ionotropic, N-methyl D-aspartate 2A
hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26)
hsa:3708 ITPR1; inositol 1,4,5-trisphosphate receptor, type 1
hsa:3800 KIF5C; kinesin family member 5C
hsa:4128 MAOA; monoamine oxidase A (EC:1.4.3.4)
hsa:1432 MAPK14; mitogen-activated protein kinase 14 (EC:2.7.11.24)
hsa:5601 MAPK9; mitogen-activated protein kinase 9 (EC:2.7.11.24)
hsa:5330 PLCB2; phospholipase C, beta 2 (EC:3.1.4.11)
hsa:5331 PLCB3; phospholipase C, beta 3 (phosphatidylinositol-specific) (EC:3.1.4.11)
hsa:5530 PPP3CA; protein phosphatase 3, catalytic subunit, alpha isozyme (EC:3.1.3.16)
hsa:5532 PPP3CB; protein phosphatase 3, catalytic subunit, beta isozyme (EC:3.1.3.16)
hsa:5533 PPP3CC; protein phosphatase 3, catalytic subunit, gamma isozyme (EC:3.1.3.16)
hsa:5578 PRKCA; protein kinase C, alpha (EC:2.7.11.13)
hsa:5579 PRKCB; protein kinase C, beta (EC:2.7.11.13)
hsa:6531 SLC6A3; solute carrier family 6 (neurotransmitter transporter, dopamine), member 3
hsa:7054 TH; tyrosine hydroxylase (EC:1.14.16.2)

hsa05160 Hepatitis C - Homo sapiens (human) (39)



cpd:C00027 Hydrogen peroxide
hsa:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1)
hsa:572 BAD; BCL2-associated agonist of cell death
hsa:1026 CDKN1A; cyclin-dependent kinase inhibitor 1A (p21, Cip1)
hsa:1147 CHUK; conserved helix-loop-helix ubiquitous kinase (EC:2.7.11.10)
hsa:9076 CLDN1; claudin 1
hsa:1365 CLDN3; claudin 3
hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26)
hsa:3434 IFIT1; interferon-induced protein with tetratricopeptide repeats 1
hsa:3439 IFNA1; interferon, alpha 1
hsa:3443 IFNA6; interferon, alpha 6
hsa:3576 IL8; interleukin 8
hsa:3659 IRF1; interferon regulatory factor 1
hsa:3716 JAK1; Janus kinase 1 (EC:2.7.10.2)
hsa:3949 LDLR; low density lipoprotein receptor
hsa:5594 MAPK1; mitogen-activated protein kinase 1 (EC:2.7.11.24)
hsa:1432 MAPK14; mitogen-activated protein kinase 14 (EC:2.7.11.24)
hsa:5595 MAPK3; mitogen-activated protein kinase 3 (EC:2.7.11.24)
hsa:5601 MAPK9; mitogen-activated protein kinase 9 (EC:2.7.11.24)
hsa:4790 NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
hsa:4792 NFKBIA; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
hsa:4939 OAS2; 2'-5'-oligoadenylate synthetase 2, 69/71kDa (EC:2.7.7.-)
hsa:100506658 OCLN; occludin (EC:2.1.1.67)
hsa:5163 PDK1; pyruvate dehydrogenase kinase, isozyme 1 (EC:2.7.11.2)
hsa:9063 PIAS2; protein inhibitor of activated STAT, 2
hsa:5290 PIK3CA; phosphoinositide-3-kinase, catalytic, alpha polypeptide (EC:2.7.11.1 2.7.1.153)
hsa:5291 PIK3CB; phosphoinositide-3-kinase, catalytic, beta polypeptide (EC:2.7.1.153)
hsa:5294 PIK3CG; phosphoinositide-3-kinase, catalytic, gamma polypeptide (EC:2.7.11.1 2.7.1.153)
hsa:5465 PPARA; peroxisome proliferator-activated receptor alpha
hsa:5970 RELA; v-rel reticuloendotheliosis viral oncogene homolog A (avian)
hsa:6041 RNASEL; ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) (EC:3.1.26.- 3.1.27.-)
hsa:9021 SOCS3; suppressor of cytokine signaling 3
hsa:6772 STAT1; signal transducer and activator of transcription 1, 91kDa
hsa:6773 STAT2; signal transducer and activator of transcription 2, 113kDa
hsa:7124 TNF; tumor necrosis factor
hsa:7132 TNFRSF1A; tumor necrosis factor receptor superfamily, member 1A
hsa:8717 TRADD; TNFRSF1A-associated via death domain
hsa:7189 TRAF6; TNF receptor-associated factor 6, E3 ubiquitin protein ligase
hsa:7297 TYK2; tyrosine kinase 2 (EC:2.7.10.2)

hsa04670 Leukocyte transendothelial migration - Homo sapiens (human) (36)



cpd:C00027 Hydrogen peroxide
cpd:C00575 3',5'-Cyclic AMP
hsa:60 ACTB; actin, beta
hsa:71 ACTG1; actin, gamma 1
hsa:87 ACTN1; actinin, alpha 1
hsa:9564 BCAR1; breast cancer anti-estrogen resistance 1
hsa:4267 CD99; CD99 molecule
hsa:9076 CLDN1; claudin 1
hsa:1365 CLDN3; claudin 3
hsa:6387 CXCL12; chemokine (C-X-C motif) ligand 12
hsa:7852 CXCR4; chemokine (C-X-C motif) receptor 4
hsa:1536 CYBB; cytochrome b-245, beta polypeptide
hsa:3383 ICAM1; intercellular adhesion molecule 1
hsa:3676 ITGA4; integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
hsa:3683 ITGAL; integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
hsa:3684 ITGAM; integrin, alpha M (complement component 3 receptor 3 subunit)
hsa:3688 ITGB1; integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
hsa:3689 ITGB2; integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
hsa:1432 MAPK14; mitogen-activated protein kinase 14 (EC:2.7.11.24)
hsa:4313 MMP2; matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24)
hsa:4318 MMP9; matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35)
hsa:4478 MSN; moesin
hsa:27035 NOX1; NADPH oxidase 1
hsa:100506658 OCLN; occludin (EC:2.1.1.67)
hsa:5290 PIK3CA; phosphoinositide-3-kinase, catalytic, alpha polypeptide (EC:2.7.11.1 2.7.1.153)
hsa:5291 PIK3CB; phosphoinositide-3-kinase, catalytic, beta polypeptide (EC:2.7.1.153)
hsa:5294 PIK3CG; phosphoinositide-3-kinase, catalytic, gamma polypeptide (EC:2.7.11.1 2.7.1.153)
hsa:5335 PLCG1; phospholipase C, gamma 1 (EC:3.1.4.11)
hsa:5578 PRKCA; protein kinase C, alpha (EC:2.7.11.13)
hsa:5579 PRKCB; protein kinase C, beta (EC:2.7.11.13)
hsa:2185 PTK2B; PTK2B protein tyrosine kinase 2 beta (EC:2.7.10.2)
hsa:5781 PTPN11; protein tyrosine phosphatase, non-receptor type 11 (EC:3.1.3.48)
hsa:7070 THY1; Thy-1 cell surface antigen
hsa:7294 TXK; TXK tyrosine kinase (EC:2.7.10.2)
hsa:7412 VCAM1; vascular cell adhesion molecule 1
hsa:7414 VCL; vinculin

hsa05134 Legionellosis - Homo sapiens (human) (35)



cpd:C00338 Lipopolysaccharide
hsa:317 APAF1; apoptotic peptidase activating factor 1
hsa:718 C3; complement component 3 (EC:3.4.21.43)
hsa:834 CASP1; caspase 1, apoptosis-related cysteine peptidase (EC:3.4.22.36)
hsa:836 CASP3; caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56)
hsa:840 CASP7; caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60)
hsa:841 CASP8; caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61)
hsa:842 CASP9; caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62)
hsa:929 CD14; CD14 molecule
hsa:1378 CR1; complement component (3b/4b) receptor 1 (Knops blood group)
hsa:2919 CXCL1; chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
hsa:2920 CXCL2; chemokine (C-X-C motif) ligand 2
hsa:2921 CXCL3; chemokine (C-X-C motif) ligand 3
hsa:54205 CYCS; cytochrome c, somatic
hsa:1917 EEF1A2; eukaryotic translation elongation factor 1 alpha 2
hsa:3312 HSPA8; heat shock 70kDa protein 8
hsa:3329 HSPD1; heat shock 60kDa protein 1 (chaperonin)
hsa:3592 IL12A; interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)
hsa:3593 IL12B; interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)
hsa:3606 IL18; interleukin 18 (interferon-gamma-inducing factor)
hsa:3553 IL1B; interleukin 1, beta
hsa:3569 IL6; interleukin 6 (interferon, beta 2)
hsa:3576 IL8; interleukin 8
hsa:3684 ITGAM; integrin, alpha M (complement component 3 receptor 3 subunit)
hsa:3689 ITGB2; integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
hsa:4615 MYD88; myeloid differentiation primary response gene (88)
hsa:4671 NAIP; NLR family, apoptosis inhibitory protein
hsa:4790 NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
hsa:4791 NFKB2; nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
hsa:4792 NFKBIA; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
hsa:5970 RELA; v-rel reticuloendotheliosis viral oncogene homolog A (avian)
hsa:51128 SAR1B; SAR1 homolog B (S. cerevisiae)
hsa:7097 TLR2; toll-like receptor 2
hsa:7099 TLR4; toll-like receptor 4
hsa:7124 TNF; tumor necrosis factor

hsa04722 Neurotrophin signaling pathway - Homo sapiens (human) (35)



cpd:C00165 Diacylglycerol
cpd:C00195 N-Acylsphingosine
hsa:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1)
hsa:572 BAD; BCL2-associated agonist of cell death
hsa:581 BAX; BCL2-associated X protein
hsa:596 BCL2; B-cell CLL/lymphoma 2
hsa:805 CALM2; calmodulin 2 (phosphorylase kinase, delta) (EC:2.7.11.19)
hsa:808 CALM3; calmodulin 3 (phosphorylase kinase, delta) (EC:2.7.11.19)
hsa:2549 GAB1; GRB2-associated binding protein 1
hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26)
hsa:51135 IRAK4; interleukin-1 receptor-associated kinase 4 (EC:2.7.11.1)
hsa:3725 JUN; jun proto-oncogene
hsa:9500 MAGED1; melanoma antigen family D, 1
hsa:5605 MAP2K2; mitogen-activated protein kinase kinase 2 (EC:2.7.12.2)
hsa:4217 MAP3K5; mitogen-activated protein kinase kinase kinase 5 (EC:2.7.11.25)
hsa:5594 MAPK1; mitogen-activated protein kinase 1 (EC:2.7.11.24)
hsa:1432 MAPK14; mitogen-activated protein kinase 14 (EC:2.7.11.24)
hsa:5595 MAPK3; mitogen-activated protein kinase 3 (EC:2.7.11.24)
hsa:5601 MAPK9; mitogen-activated protein kinase 9 (EC:2.7.11.24)
hsa:4790 NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
hsa:4792 NFKBIA; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
hsa:4793 NFKBIB; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
hsa:5163 PDK1; pyruvate dehydrogenase kinase, isozyme 1 (EC:2.7.11.2)
hsa:5290 PIK3CA; phosphoinositide-3-kinase, catalytic, alpha polypeptide (EC:2.7.11.1 2.7.1.153)
hsa:5291 PIK3CB; phosphoinositide-3-kinase, catalytic, beta polypeptide (EC:2.7.1.153)
hsa:5294 PIK3CG; phosphoinositide-3-kinase, catalytic, gamma polypeptide (EC:2.7.11.1 2.7.1.153)
hsa:5335 PLCG1; phospholipase C, gamma 1 (EC:3.1.4.11)
hsa:5781 PTPN11; protein tyrosine phosphatase, non-receptor type 11 (EC:3.1.3.48)
hsa:5970 RELA; v-rel reticuloendotheliosis viral oncogene homolog A (avian)
hsa:10603 SH2B2; SH2B adaptor protein 2
hsa:6272 SORT1; sortilin 1
hsa:7189 TRAF6; TNF receptor-associated factor 6, E3 ubiquitin protein ligase
hsa:7529 YWHAB; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide
hsa:7533 YWHAH; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide
hsa:10971 YWHAQ; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide

hsa04621 NOD-like receptor signaling pathway - Homo sapiens (human) (34)



hsa:329 BIRC2; baculoviral IAP repeat containing 2
hsa:330 BIRC3; baculoviral IAP repeat containing 3
hsa:834 CASP1; caspase 1, apoptosis-related cysteine peptidase (EC:3.4.22.36)
hsa:841 CASP8; caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61)
hsa:6347 CCL2; chemokine (C-C motif) ligand 2
hsa:6352 CCL5; chemokine (C-C motif) ligand 5
hsa:1147 CHUK; conserved helix-loop-helix ubiquitous kinase (EC:2.7.11.10)
hsa:2919 CXCL1; chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
hsa:2920 CXCL2; chemokine (C-X-C motif) ligand 2
hsa:3326 HSP90AB1; heat shock protein 90kDa alpha (cytosolic), class B member 1
hsa:7184 HSP90B1; heat shock protein 90kDa beta (Grp94), member 1
hsa:3606 IL18; interleukin 18 (interferon-gamma-inducing factor)
hsa:3553 IL1B; interleukin 1, beta
hsa:3569 IL6; interleukin 6 (interferon, beta 2)
hsa:3576 IL8; interleukin 8
hsa:6885 MAP3K7; mitogen-activated protein kinase kinase kinase 7 (EC:2.7.11.25)
hsa:5594 MAPK1; mitogen-activated protein kinase 1 (EC:2.7.11.24)
hsa:1432 MAPK14; mitogen-activated protein kinase 14 (EC:2.7.11.24)
hsa:5595 MAPK3; mitogen-activated protein kinase 3 (EC:2.7.11.24)
hsa:5601 MAPK9; mitogen-activated protein kinase 9 (EC:2.7.11.24)
hsa:4671 NAIP; NLR family, apoptosis inhibitory protein
hsa:4790 NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
hsa:4792 NFKBIA; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
hsa:4793 NFKBIB; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
hsa:22861 NLRP1; NLR family, pyrin domain containing 1
hsa:10392 NOD1; nucleotide-binding oligomerization domain containing 1
hsa:64127 NOD2; nucleotide-binding oligomerization domain containing 2
hsa:5970 RELA; v-rel reticuloendotheliosis viral oncogene homolog A (avian)
hsa:10454 TAB1; TGF-beta activated kinase 1/MAP3K7 binding protein 1
hsa:23118 TAB2; TGF-beta activated kinase 1/MAP3K7 binding protein 2
hsa:257397 TAB3; TGF-beta activated kinase 1/MAP3K7 binding protein 3
hsa:7124 TNF; tumor necrosis factor
hsa:7128 TNFAIP3; tumor necrosis factor, alpha-induced protein 3 (EC:3.4.19.12)
hsa:7189 TRAF6; TNF receptor-associated factor 6, E3 ubiquitin protein ligase

hsa04910 Insulin signaling pathway - Homo sapiens (human) (34)



cpd:C00031 D-Glucose
cpd:C00575 3',5'-Cyclic AMP
hsa:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1)
hsa:572 BAD; BCL2-associated agonist of cell death
hsa:805 CALM2; calmodulin 2 (phosphorylase kinase, delta) (EC:2.7.11.19)
hsa:808 CALM3; calmodulin 3 (phosphorylase kinase, delta) (EC:2.7.11.19)
hsa:10211 FLOT1; flotillin 1
hsa:2538 G6PC; glucose-6-phosphatase, catalytic subunit (EC:3.1.3.9)
hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26)
hsa:2997 GYS1; glycogen synthase 1 (muscle) (EC:2.4.1.11)
hsa:3098 HK1; hexokinase 1 (EC:2.7.1.1)
hsa:3099 HK2; hexokinase 2 (EC:2.7.1.1)
hsa:3101 HK3; hexokinase 3 (white cell) (EC:2.7.1.1)
hsa:3630 INS; insulin
hsa:5605 MAP2K2; mitogen-activated protein kinase kinase 2 (EC:2.7.12.2)
hsa:5594 MAPK1; mitogen-activated protein kinase 1 (EC:2.7.11.24)
hsa:5595 MAPK3; mitogen-activated protein kinase 3 (EC:2.7.11.24)
hsa:5601 MAPK9; mitogen-activated protein kinase 9 (EC:2.7.11.24)
hsa:2475 MTOR; mechanistic target of rapamycin (serine/threonine kinase) (EC:2.7.11.1)
hsa:5105 PCK1; phosphoenolpyruvate carboxykinase 1 (soluble) (EC:4.1.1.32)
hsa:5257 PHKB; phosphorylase kinase, beta (EC:2.7.11.19 2.7.1.38)
hsa:5290 PIK3CA; phosphoinositide-3-kinase, catalytic, alpha polypeptide (EC:2.7.11.1 2.7.1.153)
hsa:5291 PIK3CB; phosphoinositide-3-kinase, catalytic, beta polypeptide (EC:2.7.1.153)
hsa:5294 PIK3CG; phosphoinositide-3-kinase, catalytic, gamma polypeptide (EC:2.7.11.1 2.7.1.153)
hsa:5509 PPP1R3D; protein phosphatase 1, regulatory subunit 3D (EC:3.1.3.16)
hsa:5575 PRKAR1B; protein kinase, cAMP-dependent, regulatory, type I, beta (EC:2.7.11.1)
hsa:5770 PTPN1; protein tyrosine phosphatase, non-receptor type 1 (EC:3.1.3.48)
hsa:5836 PYGL; phosphorylase, glycogen, liver (EC:2.4.1.1)
hsa:6194 RPS6; ribosomal protein S6
hsa:6198 RPS6KB1; ribosomal protein S6 kinase, 70kDa, polypeptide 1 (EC:2.7.11.1)
hsa:10603 SH2B2; SH2B adaptor protein 2
hsa:8651 SOCS1; suppressor of cytokine signaling 1
hsa:9021 SOCS3; suppressor of cytokine signaling 3
hsa:9322 TRIP10; thyroid hormone receptor interactor 10

hsa05016 Huntington's disease - Homo sapiens (human) (34)



hsa:160 AP2A1; adaptor-related protein complex 2, alpha 1 subunit
hsa:317 APAF1; apoptotic peptidase activating factor 1
hsa:498 ATP5A1; ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle
hsa:513 ATP5D; ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit (EC:3.6.1.14)
hsa:516 ATP5G1; ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)
hsa:4508 ATP6; ATP synthase F0 subunit 6
hsa:581 BAX; BCL2-associated X protein
hsa:836 CASP3; caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56)
hsa:841 CASP8; caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61)
hsa:842 CASP9; caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62)
hsa:1211 CLTA; clathrin, light chain A
hsa:4514 COX3; cytochrome c oxidase III
hsa:1350 COX7C; cytochrome c oxidase subunit VIIc (EC:1.9.3.1)
hsa:1385 CREB1; cAMP responsive element binding protein 1
hsa:10488 CREB3; cAMP responsive element binding protein 3
hsa:9586 CREB5; cAMP responsive element binding protein 5
hsa:54205 CYCS; cytochrome c, somatic
hsa:4519 CYTB; cytochrome b
hsa:10540 DCTN2; dynactin 2 (p50)
hsa:1742 DLG4; discs, large homolog 4 (Drosophila)
hsa:3708 ITPR1; inositol 1,4,5-trisphosphate receptor, type 1
hsa:4725 NDUFS5; NADH dehydrogenase (ubiquinone) Fe-S protein 5, 15kDa (NADH-coenzyme Q reductase)
hsa:374291 NDUFS7; NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase) (EC:1.6.5.3 1.6.99.3)
hsa:4731 NDUFV3; NADH dehydrogenase (ubiquinone) flavoprotein 3, 10kDa (EC:1.6.5.3)
hsa:5330 PLCB2; phospholipase C, beta 2 (EC:3.1.4.11)
hsa:5331 PLCB3; phospholipase C, beta 3 (phosphatidylinositol-specific) (EC:3.1.4.11)
hsa:5468 PPARG; peroxisome proliferator-activated receptor gamma
hsa:10105 PPIF; peptidylprolyl isomerase F (EC:5.2.1.8)
hsa:6647 SOD1; superoxide dismutase 1, soluble (EC:1.15.1.1)
hsa:6648 SOD2; superoxide dismutase 2, mitochondrial (EC:1.15.1.1)
hsa:9519 TBPL1; TBP-like 1
hsa:7052 TGM2; transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase) (EC:2.3.2.13)
hsa:7350 UCP1; uncoupling protein 1 (mitochondrial, proton carrier)
hsa:7416 VDAC1; voltage-dependent anion channel 1

hsa05215 Prostate cancer - Homo sapiens (human) (34)



cpd:C00535 Testosterone
cpd:C00951 Estradiol-17beta
cpd:C01227 Dehydroepiandrosterone
hsa:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1)
hsa:572 BAD; BCL2-associated agonist of cell death
hsa:596 BCL2; B-cell CLL/lymphoma 2
hsa:842 CASP9; caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62)
hsa:595 CCND1; cyclin D1
hsa:1017 CDK2; cyclin-dependent kinase 2 (EC:2.7.11.22)
hsa:1026 CDKN1A; cyclin-dependent kinase inhibitor 1A (p21, Cip1)
hsa:1027 CDKN1B; cyclin-dependent kinase inhibitor 1B (p27, Kip1)
hsa:1147 CHUK; conserved helix-loop-helix ubiquitous kinase (EC:2.7.11.10)
hsa:1385 CREB1; cAMP responsive element binding protein 1
hsa:10488 CREB3; cAMP responsive element binding protein 3
hsa:9586 CREB5; cAMP responsive element binding protein 5
hsa:2064 ERBB2; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) (EC:2.7.10.1)
hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26)
hsa:3326 HSP90AB1; heat shock protein 90kDa alpha (cytosolic), class B member 1
hsa:7184 HSP90B1; heat shock protein 90kDa beta (Grp94), member 1
hsa:3479 IGF1; insulin-like growth factor 1 (somatomedin C)
hsa:3630 INS; insulin
hsa:5605 MAP2K2; mitogen-activated protein kinase kinase 2 (EC:2.7.12.2)
hsa:5594 MAPK1; mitogen-activated protein kinase 1 (EC:2.7.11.24)
hsa:5595 MAPK3; mitogen-activated protein kinase 3 (EC:2.7.11.24)
hsa:2475 MTOR; mechanistic target of rapamycin (serine/threonine kinase) (EC:2.7.11.1)
hsa:4790 NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
hsa:4792 NFKBIA; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
hsa:5154 PDGFA; platelet-derived growth factor alpha polypeptide
hsa:5155 PDGFB; platelet-derived growth factor beta polypeptide
hsa:5290 PIK3CA; phosphoinositide-3-kinase, catalytic, alpha polypeptide (EC:2.7.11.1 2.7.1.153)
hsa:5291 PIK3CB; phosphoinositide-3-kinase, catalytic, beta polypeptide (EC:2.7.1.153)
hsa:5294 PIK3CG; phosphoinositide-3-kinase, catalytic, gamma polypeptide (EC:2.7.11.1 2.7.1.153)
hsa:5970 RELA; v-rel reticuloendotheliosis viral oncogene homolog A (avian)
hsa:6934 TCF7L2; transcription factor 7-like 2 (T-cell specific, HMG-box)

hsa04141 Protein processing in endoplasmic reticulum - Homo sapiens (human) (33)



hsa:1388 ATF6B; activating transcription factor 6 beta
hsa:4287 ATXN3; ataxin 3 (EC:3.4.19.12)
hsa:581 BAX; BCL2-associated X protein
hsa:596 BCL2; B-cell CLL/lymphoma 2
hsa:811 CALR; calreticulin
hsa:821 CANX; calnexin
hsa:823 CAPN1; calpain 1, (mu/I) large subunit (EC:3.4.22.52)
hsa:824 CAPN2; calpain 2, (m/II) large subunit (EC:3.4.22.53)
hsa:10970 CKAP4; cytoskeleton-associated protein 4
hsa:1603 DAD1; defender against cell death 1 (EC:2.4.1.119)
hsa:1649 DDIT3; DNA-damage-inducible transcript 3
hsa:51009 DERL2; Der1-like domain family, member 2
hsa:3301 DNAJA1; DnaJ (Hsp40) homolog, subfamily A, member 1
hsa:56605 ERO1LB; ERO1-like beta (S. cerevisiae)
hsa:10961 ERP29; endoplasmic reticulum protein 29
hsa:3326 HSP90AB1; heat shock protein 90kDa alpha (cytosolic), class B member 1
hsa:7184 HSP90B1; heat shock protein 90kDa beta (Grp94), member 1
hsa:3309 HSPA5; heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
hsa:3312 HSPA8; heat shock 70kDa protein 8
hsa:4217 MAP3K5; mitogen-activated protein kinase kinase kinase 5 (EC:2.7.11.25)
hsa:5601 MAPK9; mitogen-activated protein kinase 9 (EC:2.7.11.24)
hsa:4780 NFE2L2; nuclear factor (erythroid-derived 2)-like 2
hsa:55968 NSFL1C; NSFL1 (p97) cofactor (p47)
hsa:5034 P4HB; prolyl 4-hydroxylase, beta polypeptide (EC:5.3.4.1)
hsa:23645 PPP1R15A; protein phosphatase 1, regulatory subunit 15A
hsa:5887 RAD23B; RAD23 homolog B (S. cerevisiae)
hsa:6238 RRBP1; ribosome binding protein 1 homolog 180kDa (dog)
hsa:51128 SAR1B; SAR1 homolog B (S. cerevisiae)
hsa:6400 SEL1L; sel-1 suppressor of lin-12-like (C. elegans)
hsa:81567 TXNDC5; thioredoxin domain containing 5 (endoplasmic reticulum)
hsa:7322 UBE2D2; ubiquitin-conjugating enzyme E2D 2 (EC:6.3.2.19)
hsa:29978 UBQLN2; ubiquilin 2
hsa:7353 UFD1L; ubiquitin fusion degradation 1 like (yeast)

hsa05144 Malaria - Homo sapiens (human) (32)



cpd:C00533 Nitric oxide
hsa:6347 CCL2; chemokine (C-C motif) ligand 2
hsa:948 CD36; CD36 molecule (thrombospondin receptor)
hsa:958 CD40; CD40 molecule, TNF receptor superfamily member 5
hsa:959 CD40LG; CD40 ligand
hsa:1378 CR1; complement component (3b/4b) receptor 1 (Knops blood group)
hsa:1440 CSF3; colony stimulating factor 3 (granulocyte)
hsa:2995 GYPC; glycophorin C (Gerbich blood group)
hsa:3383 ICAM1; intercellular adhesion molecule 1
hsa:3458 IFNG; interferon, gamma
hsa:3586 IL10; interleukin 10
hsa:3592 IL12A; interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)
hsa:3606 IL18; interleukin 18 (interferon-gamma-inducing factor)
hsa:3553 IL1B; interleukin 1, beta
hsa:3569 IL6; interleukin 6 (interferon, beta 2)
hsa:3576 IL8; interleukin 8
hsa:3683 ITGAL; integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
hsa:3689 ITGB2; integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
hsa:22914 KLRK1; killer cell lectin-like receptor subfamily K, member 1
hsa:4035 LRP1; low density lipoprotein receptor-related protein 1
hsa:4615 MYD88; myeloid differentiation primary response gene (88)
hsa:6382 SDC1; syndecan 1
hsa:6383 SDC2; syndecan 2
hsa:9672 SDC3; syndecan 3
hsa:6385 SDC4; syndecan 4
hsa:7040 TGFB1; transforming growth factor, beta 1
hsa:7057 THBS1; thrombospondin 1
hsa:7097 TLR2; toll-like receptor 2
hsa:7099 TLR4; toll-like receptor 4
hsa:54106 TLR9; toll-like receptor 9
hsa:7124 TNF; tumor necrosis factor
hsa:7412 VCAM1; vascular cell adhesion molecule 1

hsa00240 Pyrimidine metabolism - Homo sapiens (human) (31)



cpd:C00064 L-Glutamine
cpd:C00214 Thymidine
cpd:C00299 Uridine
cpd:C00475 Cytidine
hsa:1633 DCK; deoxycytidine kinase (EC:2.7.1.74)
hsa:1635 DCTD; dCMP deaminase (EC:3.5.4.12)
hsa:1806 DPYD; dihydropyrimidine dehydrogenase (EC:1.3.1.2)
hsa:4830 NME1; non-metastatic cells 1, protein (NM23A) expressed in (EC:2.7.4.6)
hsa:4831 NME2; non-metastatic cells 2, protein (NM23B) expressed in (EC:2.7.4.6 2.7.13.3)
hsa:4833 NME4; non-metastatic cells 4, protein expressed in (EC:2.7.4.6)
hsa:10201 NME6; non-metastatic cells 6, protein expressed in (nucleoside-diphosphate kinase) (EC:2.7.4.6)
hsa:93034 NT5C1B; 5'-nucleotidase, cytosolic IB (EC:3.1.3.5)
hsa:4907 NT5E; 5'-nucleotidase, ecto (CD73) (EC:3.1.3.5)
hsa:4860 PNP; purine nucleoside phosphorylase (EC:2.4.2.1)
hsa:54107 POLE3; polymerase (DNA directed), epsilon 3 (p17 subunit) (EC:2.7.7.7)
hsa:25885 POLR1A; polymerase (RNA) I polypeptide A, 194kDa (EC:2.7.7.6)
hsa:84172 POLR1B; polymerase (RNA) I polypeptide B, 128kDa (EC:2.7.7.6)
hsa:9533 POLR1C; polymerase (RNA) I polypeptide C, 30kDa
hsa:51082 POLR1D; polymerase (RNA) I polypeptide D, 16kDa
hsa:64425 POLR1E; polymerase (RNA) I polypeptide E, 53kDa
hsa:55718 POLR3E; polymerase (RNA) III (DNA directed) polypeptide E (80kD)
hsa:51728 POLR3K; polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
hsa:5557 PRIM1; primase, DNA, polypeptide 1 (49kDa) (EC:2.7.7.-)
hsa:50484 RRM2B; ribonucleotide reductase M2 B (TP53 inducible) (EC:1.17.4.1)
hsa:7083 TK1; thymidine kinase 1, soluble (EC:2.7.1.21)
hsa:221830 TWISTNB; TWIST neighbor
hsa:7296 TXNRD1; thioredoxin reductase 1 (EC:1.8.1.9)
hsa:1890 TYMP; thymidine phosphorylase (EC:2.4.2.4)
hsa:7298 TYMS; thymidylate synthetase (EC:2.1.1.45)
hsa:7372 UMPS; uridine monophosphate synthetase (EC:2.4.2.10 4.1.1.23)
hsa:7378 UPP1; uridine phosphorylase 1 (EC:2.4.2.3)

hsa04310 Wnt signaling pathway - Homo sapiens (human) (31)



hsa:8313 AXIN2; axin 2
hsa:595 CCND1; cyclin D1
hsa:1488 CTBP2; C-terminal binding protein 2
hsa:80319 CXXC4; CXXC finger protein 4
hsa:27123 DKK2; dickkopf 2 homolog (Xenopus laevis)
hsa:8322 FZD4; frizzled family receptor 4
hsa:8324 FZD7; frizzled family receptor 7
hsa:2239 GPC4; glypican 4
hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26)
hsa:3725 JUN; jun proto-oncogene
hsa:6885 MAP3K7; mitogen-activated protein kinase kinase kinase 7 (EC:2.7.11.25)
hsa:5601 MAPK9; mitogen-activated protein kinase 9 (EC:2.7.11.24)
hsa:4609 MYC; v-myc myelocytomatosis viral oncogene homolog (avian)
hsa:4772 NFATC1; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
hsa:5330 PLCB2; phospholipase C, beta 2 (EC:3.1.4.11)
hsa:5331 PLCB3; phospholipase C, beta 3 (phosphatidylinositol-specific) (EC:3.1.4.11)
hsa:5467 PPARD; peroxisome proliferator-activated receptor delta
hsa:5530 PPP3CA; protein phosphatase 3, catalytic subunit, alpha isozyme (EC:3.1.3.16)
hsa:5532 PPP3CB; protein phosphatase 3, catalytic subunit, beta isozyme (EC:3.1.3.16)
hsa:5533 PPP3CC; protein phosphatase 3, catalytic subunit, gamma isozyme (EC:3.1.3.16)
hsa:5534 PPP3R1; protein phosphatase 3, regulatory subunit B, alpha (EC:3.1.3.16)
hsa:5535 PPP3R2; protein phosphatase 3, regulatory subunit B, beta (EC:3.1.3.16)
hsa:144165 PRICKLE1; prickle homolog 1 (Drosophila)
hsa:5578 PRKCA; protein kinase C, alpha (EC:2.7.11.13)
hsa:5579 PRKCB; protein kinase C, beta (EC:2.7.11.13)
hsa:6422 SFRP1; secreted frizzled-related protein 1
hsa:6423 SFRP2; secreted frizzled-related protein 2
hsa:4087 SMAD2; SMAD family member 2
hsa:6934 TCF7L2; transcription factor 7-like 2 (T-cell specific, HMG-box)
hsa:81839 VANGL1; vang-like 1 (van gogh, Drosophila)
hsa:7474 WNT5A; wingless-type MMTV integration site family, member 5A

hsa04512 ECM-receptor interaction - Homo sapiens (human) (31)



hsa:375790 AGRN; agrin
hsa:948 CD36; CD36 molecule (thrombospondin receptor)
hsa:960 CD44; CD44 molecule (Indian blood group)
hsa:1277 COL1A1; collagen, type I, alpha 1
hsa:1278 COL1A2; collagen, type I, alpha 2
hsa:1280 COL2A1; collagen, type II, alpha 1
hsa:1287 COL4A5; collagen, type IV, alpha 5
hsa:1291 COL6A1; collagen, type VI, alpha 1
hsa:1293 COL6A3; collagen, type VI, alpha 3
hsa:2335 FN1; fibronectin 1
hsa:2811 GP1BA; glycoprotein Ib (platelet), alpha polypeptide
hsa:3339 HSPG2; heparan sulfate proteoglycan 2
hsa:3673 ITGA2; integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
hsa:3676 ITGA4; integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
hsa:3678 ITGA5; integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
hsa:3655 ITGA6; integrin, alpha 6
hsa:8516 ITGA8; integrin, alpha 8
hsa:3680 ITGA9; integrin, alpha 9
hsa:3688 ITGB1; integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
hsa:3690 ITGB3; integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
hsa:3693 ITGB5; integrin, beta 5
hsa:3695 ITGB7; integrin, beta 7
hsa:3910 LAMA4; laminin, alpha 4
hsa:3914 LAMB3; laminin, beta 3
hsa:6382 SDC1; syndecan 1
hsa:6383 SDC2; syndecan 2
hsa:9672 SDC3; syndecan 3
hsa:6385 SDC4; syndecan 4
hsa:6696 SPP1; secreted phosphoprotein 1
hsa:7057 THBS1; thrombospondin 1
hsa:3371 TNC; tenascin C

hsa04726 Serotonergic synapse - Homo sapiens (human) (31)



cpd:C00078 L-Tryptophan
cpd:C00165 Diacylglycerol
cpd:C00219 Arachidonate
cpd:C00238 Potassium cation
cpd:C00575 3',5'-Cyclic AMP
cpd:C00584 Prostaglandin E2
cpd:C02165 Leukotriene B4
cpd:C02166 Leukotriene C4
hsa:239 ALOX12; arachidonate 12-lipoxygenase (EC:1.13.11.31)
hsa:246 ALOX15; arachidonate 15-lipoxygenase (EC:1.13.11.33)
hsa:240 ALOX5; arachidonate 5-lipoxygenase (EC:1.13.11.34)
hsa:351 APP; amyloid beta (A4) precursor protein
hsa:836 CASP3; caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56)
hsa:1644 DDC; dopa decarboxylase (aromatic L-amino acid decarboxylase) (EC:4.1.1.28)
hsa:1843 DUSP1; dual specificity phosphatase 1 (EC:3.1.3.16 3.1.3.48)
hsa:2562 GABRB3; gamma-aminobutyric acid (GABA) A receptor, beta 3
hsa:59345 GNB4; guanine nucleotide binding protein (G protein), beta polypeptide 4
hsa:55970 GNG12; guanine nucleotide binding protein (G protein), gamma 12
hsa:2793 GNGT2; guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2
hsa:3352 HTR1D; 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled
hsa:285242 HTR3E; 5-hydroxytryptamine (serotonin) receptor 3E, ionotropic
hsa:3708 ITPR1; inositol 1,4,5-trisphosphate receptor, type 1
hsa:4128 MAOA; monoamine oxidase A (EC:1.4.3.4)
hsa:5594 MAPK1; mitogen-activated protein kinase 1 (EC:2.7.11.24)
hsa:5595 MAPK3; mitogen-activated protein kinase 3 (EC:2.7.11.24)
hsa:5321 PLA2G4A; phospholipase A2, group IVA (cytosolic, calcium-dependent) (EC:3.1.1.5 3.1.1.4)
hsa:5330 PLCB2; phospholipase C, beta 2 (EC:3.1.4.11)
hsa:5331 PLCB3; phospholipase C, beta 3 (phosphatidylinositol-specific) (EC:3.1.4.11)
hsa:5578 PRKCA; protein kinase C, alpha (EC:2.7.11.13)
hsa:5579 PRKCB; protein kinase C, beta (EC:2.7.11.13)
hsa:5743 PTGS2; prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1)

hsa05222 Small cell lung cancer - Homo sapiens (human) (31)



hsa:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1)
hsa:317 APAF1; apoptotic peptidase activating factor 1
hsa:596 BCL2; B-cell CLL/lymphoma 2
hsa:329 BIRC2; baculoviral IAP repeat containing 2
hsa:330 BIRC3; baculoviral IAP repeat containing 3
hsa:842 CASP9; caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62)
hsa:595 CCND1; cyclin D1
hsa:1017 CDK2; cyclin-dependent kinase 2 (EC:2.7.11.22)
hsa:1027 CDKN1B; cyclin-dependent kinase inhibitor 1B (p27, Kip1)
hsa:1147 CHUK; conserved helix-loop-helix ubiquitous kinase (EC:2.7.11.10)
hsa:1287 COL4A5; collagen, type IV, alpha 5
hsa:54205 CYCS; cytochrome c, somatic
hsa:2335 FN1; fibronectin 1
hsa:3673 ITGA2; integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
hsa:3655 ITGA6; integrin, alpha 6
hsa:3688 ITGB1; integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
hsa:3910 LAMA4; laminin, alpha 4
hsa:3914 LAMB3; laminin, beta 3
hsa:4149 MAX; MYC associated factor X
hsa:4609 MYC; v-myc myelocytomatosis viral oncogene homolog (avian)
hsa:4790 NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
hsa:4792 NFKBIA; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
hsa:4843 NOS2; nitric oxide synthase 2, inducible (EC:1.14.13.39)
hsa:9063 PIAS2; protein inhibitor of activated STAT, 2
hsa:5290 PIK3CA; phosphoinositide-3-kinase, catalytic, alpha polypeptide (EC:2.7.11.1 2.7.1.153)
hsa:5291 PIK3CB; phosphoinositide-3-kinase, catalytic, beta polypeptide (EC:2.7.1.153)
hsa:5294 PIK3CG; phosphoinositide-3-kinase, catalytic, gamma polypeptide (EC:2.7.11.1 2.7.1.153)
hsa:5743 PTGS2; prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1)
hsa:5970 RELA; v-rel reticuloendotheliosis viral oncogene homolog A (avian)
hsa:7185 TRAF1; TNF receptor-associated factor 1
hsa:7189 TRAF6; TNF receptor-associated factor 6, E3 ubiquitin protein ligase

hsa05416 Viral myocarditis - Homo sapiens (human) (31)



hsa:60 ACTB; actin, beta
hsa:71 ACTG1; actin, gamma 1
hsa:637 BID; BH3 interacting domain death agonist
hsa:836 CASP3; caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56)
hsa:841 CASP8; caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61)
hsa:842 CASP9; caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62)
hsa:857 CAV1; caveolin 1, caveolae protein, 22kDa
hsa:595 CCND1; cyclin D1
hsa:940 CD28; CD28 molecule
hsa:958 CD40; CD40 molecule, TNF receptor superfamily member 5
hsa:959 CD40LG; CD40 ligand
hsa:1604 CD55; CD55 molecule, decay accelerating factor for complement (Cromer blood group)
hsa:941 CD80; CD80 molecule
hsa:942 CD86; CD86 molecule
hsa:1525 CXADR; coxsackie virus and adenovirus receptor
hsa:54205 CYCS; cytochrome c, somatic
hsa:1982 EIF4G2; eukaryotic translation initiation factor 4 gamma, 2
hsa:2534 FYN; FYN oncogene related to SRC, FGR, YES (EC:2.7.10.2)
hsa:3105 HLA-A; major histocompatibility complex, class I, A
hsa:3107 HLA-C; major histocompatibility complex, class I, C
hsa:3109 HLA-DMB; major histocompatibility complex, class II, DM beta
hsa:3118 HLA-DQA2; major histocompatibility complex, class II, DQ alpha 2
hsa:3134 HLA-F; major histocompatibility complex, class I, F
hsa:3135 HLA-G; major histocompatibility complex, class I, G
hsa:3383 ICAM1; intercellular adhesion molecule 1
hsa:3683 ITGAL; integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
hsa:3689 ITGB2; integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
hsa:4628 MYH10; myosin, heavy chain 10, non-muscle
hsa:4624 MYH6; myosin, heavy chain 6, cardiac muscle, alpha
hsa:4627 MYH9; myosin, heavy chain 9, non-muscle
hsa:5551 PRF1; perforin 1 (pore forming protein)

hsa05014 Amyotrophic lateral sclerosis (ALS) - Homo sapiens (human) (30)



cpd:C00027 Hydrogen peroxide
cpd:C00062 L-Arginine
cpd:C00533 Nitric oxide
hsa:317 APAF1; apoptotic peptidase activating factor 1
hsa:572 BAD; BCL2-associated agonist of cell death
hsa:581 BAX; BCL2-associated X protein
hsa:596 BCL2; B-cell CLL/lymphoma 2
hsa:637 BID; BH3 interacting domain death agonist
hsa:834 CASP1; caspase 1, apoptosis-related cysteine peptidase (EC:3.4.22.36)
hsa:836 CASP3; caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56)
hsa:842 CASP9; caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62)
hsa:847 CAT; catalase (EC:1.11.1.6)
hsa:9973 CCS; copper chaperone for superoxide dismutase
hsa:54205 CYCS; cytochrome c, somatic
hsa:2903 GRIN2A; glutamate receptor, ionotropic, N-methyl D-aspartate 2A
hsa:5606 MAP2K3; mitogen-activated protein kinase kinase 3 (EC:2.7.12.2)
hsa:5608 MAP2K6; mitogen-activated protein kinase kinase 6 (EC:2.7.12.2)
hsa:4217 MAP3K5; mitogen-activated protein kinase kinase kinase 5 (EC:2.7.11.25)
hsa:1432 MAPK14; mitogen-activated protein kinase 14 (EC:2.7.11.24)
hsa:4842 NOS1; nitric oxide synthase 1 (neuronal) (EC:1.14.13.39)
hsa:5530 PPP3CA; protein phosphatase 3, catalytic subunit, alpha isozyme (EC:3.1.3.16)
hsa:5532 PPP3CB; protein phosphatase 3, catalytic subunit, beta isozyme (EC:3.1.3.16)
hsa:5533 PPP3CC; protein phosphatase 3, catalytic subunit, gamma isozyme (EC:3.1.3.16)
hsa:5534 PPP3R1; protein phosphatase 3, regulatory subunit B, alpha (EC:3.1.3.16)
hsa:5535 PPP3R2; protein phosphatase 3, regulatory subunit B, beta (EC:3.1.3.16)
hsa:6647 SOD1; superoxide dismutase 1, soluble (EC:1.15.1.1)
hsa:7124 TNF; tumor necrosis factor
hsa:7132 TNFRSF1A; tumor necrosis factor receptor superfamily, member 1A
hsa:7133 TNFRSF1B; tumor necrosis factor receptor superfamily, member 1B
hsa:10452 TOMM40; translocase of outer mitochondrial membrane 40 homolog (yeast)

hsa04724 Glutamatergic synapse - Homo sapiens (human) (30)



cpd:C00064 L-Glutamine
cpd:C00165 Diacylglycerol
cpd:C00238 Potassium cation
cpd:C00575 3',5'-Cyclic AMP
hsa:109 ADCY3; adenylate cyclase 3 (EC:4.6.1.1)
hsa:112 ADCY6; adenylate cyclase 6 (EC:4.6.1.1)
hsa:1742 DLG4; discs, large homolog 4 (Drosophila)
hsa:2744 GLS; glutaminase (EC:3.5.1.2)
hsa:27165 GLS2; glutaminase 2 (liver, mitochondrial) (EC:3.5.1.2)
hsa:2752 GLUL; glutamate-ammonia ligase (EC:4.1.1.15 6.3.1.2)
hsa:59345 GNB4; guanine nucleotide binding protein (G protein), beta polypeptide 4
hsa:55970 GNG12; guanine nucleotide binding protein (G protein), gamma 12
hsa:2793 GNGT2; guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2
hsa:2903 GRIN2A; glutamate receptor, ionotropic, N-methyl D-aspartate 2A
hsa:9456 HOMER1; homer homolog 1 (Drosophila)
hsa:3708 ITPR1; inositol 1,4,5-trisphosphate receptor, type 1
hsa:5594 MAPK1; mitogen-activated protein kinase 1 (EC:2.7.11.24)
hsa:5595 MAPK3; mitogen-activated protein kinase 3 (EC:2.7.11.24)
hsa:5321 PLA2G4A; phospholipase A2, group IVA (cytosolic, calcium-dependent) (EC:3.1.1.5 3.1.1.4)
hsa:5330 PLCB2; phospholipase C, beta 2 (EC:3.1.4.11)
hsa:5331 PLCB3; phospholipase C, beta 3 (phosphatidylinositol-specific) (EC:3.1.4.11)
hsa:5337 PLD1; phospholipase D1, phosphatidylcholine-specific (EC:3.1.4.4)
hsa:5530 PPP3CA; protein phosphatase 3, catalytic subunit, alpha isozyme (EC:3.1.3.16)
hsa:5532 PPP3CB; protein phosphatase 3, catalytic subunit, beta isozyme (EC:3.1.3.16)
hsa:5533 PPP3CC; protein phosphatase 3, catalytic subunit, gamma isozyme (EC:3.1.3.16)
hsa:5534 PPP3R1; protein phosphatase 3, regulatory subunit B, alpha (EC:3.1.3.16)
hsa:5535 PPP3R2; protein phosphatase 3, regulatory subunit B, beta (EC:3.1.3.16)
hsa:5578 PRKCA; protein kinase C, alpha (EC:2.7.11.13)
hsa:5579 PRKCB; protein kinase C, beta (EC:2.7.11.13)
hsa:6507 SLC1A3; solute carrier family 1 (glial high affinity glutamate transporter), member 3

hsa04664 Fc epsilon RI signaling pathway - Homo sapiens (human) (29)



cpd:C00165 Diacylglycerol
cpd:C00219 Arachidonate
cpd:C00374 Heparin
cpd:C02166 Leukotriene C4
cpd:C05951 Leukotriene D4
hsa:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1)
hsa:1437 CSF2; colony stimulating factor 2 (granulocyte-macrophage)
hsa:2534 FYN; FYN oncogene related to SRC, FGR, YES (EC:2.7.10.2)
hsa:3596 IL13; interleukin 13
hsa:3562 IL3; interleukin 3 (colony-stimulating factor, multiple)
hsa:3565 IL4; interleukin 4
hsa:3567 IL5; interleukin 5 (colony-stimulating factor, eosinophil)
hsa:5605 MAP2K2; mitogen-activated protein kinase kinase 2 (EC:2.7.12.2)
hsa:5606 MAP2K3; mitogen-activated protein kinase kinase 3 (EC:2.7.12.2)
hsa:6416 MAP2K4; mitogen-activated protein kinase kinase 4 (EC:2.7.12.2)
hsa:5608 MAP2K6; mitogen-activated protein kinase kinase 6 (EC:2.7.12.2)
hsa:5594 MAPK1; mitogen-activated protein kinase 1 (EC:2.7.11.24)
hsa:1432 MAPK14; mitogen-activated protein kinase 14 (EC:2.7.11.24)
hsa:5595 MAPK3; mitogen-activated protein kinase 3 (EC:2.7.11.24)
hsa:5601 MAPK9; mitogen-activated protein kinase 9 (EC:2.7.11.24)
hsa:5163 PDK1; pyruvate dehydrogenase kinase, isozyme 1 (EC:2.7.11.2)
hsa:5290 PIK3CA; phosphoinositide-3-kinase, catalytic, alpha polypeptide (EC:2.7.11.1 2.7.1.153)
hsa:5291 PIK3CB; phosphoinositide-3-kinase, catalytic, beta polypeptide (EC:2.7.1.153)
hsa:5294 PIK3CG; phosphoinositide-3-kinase, catalytic, gamma polypeptide (EC:2.7.11.1 2.7.1.153)
hsa:5321 PLA2G4A; phospholipase A2, group IVA (cytosolic, calcium-dependent) (EC:3.1.1.5 3.1.1.4)
hsa:5335 PLCG1; phospholipase C, gamma 1 (EC:3.1.4.11)
hsa:5578 PRKCA; protein kinase C, alpha (EC:2.7.11.13)
hsa:5579 PRKCB; protein kinase C, beta (EC:2.7.11.13)
hsa:7124 TNF; tumor necrosis factor

hsa04666 Fc gamma R-mediated phagocytosis - Homo sapiens (human) (29)



cpd:C00165 Diacylglycerol
cpd:C00219 Arachidonate
hsa:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1)
hsa:382 ARF6; ADP-ribosylation factor 6
hsa:10552 ARPC1A; actin related protein 2/3 complex, subunit 1A, 41kDa
hsa:10095 ARPC1B; actin related protein 2/3 complex, subunit 1B, 41kDa
hsa:10109 ARPC2; actin related protein 2/3 complex, subunit 2, 34kDa
hsa:10094 ARPC3; actin related protein 2/3 complex, subunit 3, 21kDa
hsa:10093 ARPC4; actin related protein 2/3 complex, subunit 4, 20kDa
hsa:10092 ARPC5; actin related protein 2/3 complex, subunit 5, 16kDa
hsa:81873 ARPC5L; actin related protein 2/3 complex, subunit 5-like
hsa:1072 CFL1; cofilin 1 (non-muscle)
hsa:1759 DNM1; dynamin 1 (EC:3.6.5.5)
hsa:2209 FCGR1A; Fc fragment of IgG, high affinity Ia, receptor (CD64)
hsa:2213 FCGR2B; Fc fragment of IgG, low affinity IIb, receptor (CD32)
hsa:2214 FCGR3A; Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
hsa:5594 MAPK1; mitogen-activated protein kinase 1 (EC:2.7.11.24)
hsa:5595 MAPK3; mitogen-activated protein kinase 3 (EC:2.7.11.24)
hsa:4082 MARCKS; myristoylated alanine-rich protein kinase C substrate
hsa:65108 MARCKSL1; MARCKS-like 1
hsa:5290 PIK3CA; phosphoinositide-3-kinase, catalytic, alpha polypeptide (EC:2.7.11.1 2.7.1.153)
hsa:5291 PIK3CB; phosphoinositide-3-kinase, catalytic, beta polypeptide (EC:2.7.1.153)
hsa:5294 PIK3CG; phosphoinositide-3-kinase, catalytic, gamma polypeptide (EC:2.7.11.1 2.7.1.153)
hsa:5321 PLA2G4A; phospholipase A2, group IVA (cytosolic, calcium-dependent) (EC:3.1.1.5 3.1.1.4)
hsa:5335 PLCG1; phospholipase C, gamma 1 (EC:3.1.4.11)
hsa:5337 PLD1; phospholipase D1, phosphatidylcholine-specific (EC:3.1.4.4)
hsa:5578 PRKCA; protein kinase C, alpha (EC:2.7.11.13)
hsa:5579 PRKCB; protein kinase C, beta (EC:2.7.11.13)
hsa:6198 RPS6KB1; ribosomal protein S6 kinase, 70kDa, polypeptide 1 (EC:2.7.11.1)

hsa05131 Shigellosis - Homo sapiens (human) (29)



hsa:60 ACTB; actin, beta
hsa:71 ACTG1; actin, gamma 1
hsa:10552 ARPC1A; actin related protein 2/3 complex, subunit 1A, 41kDa
hsa:10095 ARPC1B; actin related protein 2/3 complex, subunit 1B, 41kDa
hsa:10109 ARPC2; actin related protein 2/3 complex, subunit 2, 34kDa
hsa:10094 ARPC3; actin related protein 2/3 complex, subunit 3, 21kDa
hsa:10093 ARPC4; actin related protein 2/3 complex, subunit 4, 20kDa
hsa:10092 ARPC5; actin related protein 2/3 complex, subunit 5, 16kDa
hsa:81873 ARPC5L; actin related protein 2/3 complex, subunit 5-like
hsa:9474 ATG5; ATG5 autophagy related 5 homolog (S. cerevisiae)
hsa:960 CD44; CD44 molecule (Indian blood group)
hsa:1147 CHUK; conserved helix-loop-helix ubiquitous kinase (EC:2.7.11.10)
hsa:2017 CTTN; cortactin
hsa:3576 IL8; interleukin 8
hsa:3678 ITGA5; integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
hsa:3688 ITGB1; integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
hsa:5594 MAPK1; mitogen-activated protein kinase 1 (EC:2.7.11.24)
hsa:1432 MAPK14; mitogen-activated protein kinase 14 (EC:2.7.11.24)
hsa:5595 MAPK3; mitogen-activated protein kinase 3 (EC:2.7.11.24)
hsa:5601 MAPK9; mitogen-activated protein kinase 9 (EC:2.7.11.24)
hsa:4790 NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
hsa:4792 NFKBIA; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
hsa:4793 NFKBIB; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
hsa:10392 NOD1; nucleotide-binding oligomerization domain containing 1
hsa:64127 NOD2; nucleotide-binding oligomerization domain containing 2
hsa:5970 RELA; v-rel reticuloendotheliosis viral oncogene homolog A (avian)
hsa:391 RHOG; ras homolog family member G
hsa:7322 UBE2D2; ubiquitin-conjugating enzyme E2D 2 (EC:6.3.2.19)
hsa:7414 VCL; vinculin

hsa03320 PPAR signaling pathway - Homo sapiens (human) (29)



cpd:C02165 Leukotriene B4
cpd:C14762 13(S)-HODE
cpd:C14767 9(S)-HODE
hsa:33 ACADL; acyl-CoA dehydrogenase, long chain (EC:1.3.99.13)
hsa:51 ACOX1; acyl-CoA oxidase 1, palmitoyl (EC:1.3.3.6)
hsa:2180 ACSL1; acyl-CoA synthetase long-chain family member 1 (EC:6.2.1.3)
hsa:51129 ANGPTL4; angiopoietin-like 4
hsa:948 CD36; CD36 molecule (thrombospondin receptor)
hsa:1374 CPT1A; carnitine palmitoyltransferase 1A (liver) (EC:2.3.1.21)
hsa:126129 CPT1C; carnitine palmitoyltransferase 1C (EC:2.3.1.21)
hsa:1622 DBI; diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein) (EC:3.4.17.3)
hsa:2167 FABP4; fatty acid binding protein 4, adipocyte
hsa:2171 FABP5; fatty acid binding protein 5 (psoriasis-associated)
hsa:2173 FABP7; fatty acid binding protein 7, brain
hsa:9415 FADS2; fatty acid desaturase 2 (EC:1.14.19.-)
hsa:2710 GK; glycerol kinase (EC:2.7.1.30)
hsa:3158 HMGCS2; 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) (EC:2.3.3.10)
hsa:3611 ILK; integrin-linked kinase (EC:2.7.11.1)
hsa:4023 LPL; lipoprotein lipase (EC:3.1.1.34)
hsa:4312 MMP1; matrix metallopeptidase 1 (interstitial collagenase) (EC:3.4.24.7)
hsa:4973 OLR1; oxidized low density lipoprotein (lectin-like) receptor 1
hsa:5105 PCK1; phosphoenolpyruvate carboxykinase 1 (soluble) (EC:4.1.1.32)
hsa:5360 PLTP; phospholipid transfer protein
hsa:5465 PPARA; peroxisome proliferator-activated receptor alpha
hsa:5467 PPARD; peroxisome proliferator-activated receptor delta
hsa:5468 PPARG; peroxisome proliferator-activated receptor gamma
hsa:376497 SLC27A1; solute carrier family 27 (fatty acid transporter), member 1
hsa:11001 SLC27A2; solute carrier family 27 (fatty acid transporter), member 2 (EC:6.2.1.3)
hsa:7350 UCP1; uncoupling protein 1 (mitochondrial, proton carrier)

hsa04912 GnRH signaling pathway - Homo sapiens (human) (28)



cpd:C00165 Diacylglycerol
cpd:C00219 Arachidonate
cpd:C00575 3',5'-Cyclic AMP
hsa:109 ADCY3; adenylate cyclase 3 (EC:4.6.1.1)
hsa:112 ADCY6; adenylate cyclase 6 (EC:4.6.1.1)
hsa:805 CALM2; calmodulin 2 (phosphorylase kinase, delta) (EC:2.7.11.19)
hsa:808 CALM3; calmodulin 3 (phosphorylase kinase, delta) (EC:2.7.11.19)
hsa:1839 HBEGF; heparin-binding EGF-like growth factor
hsa:3708 ITPR1; inositol 1,4,5-trisphosphate receptor, type 1
hsa:3725 JUN; jun proto-oncogene
hsa:5605 MAP2K2; mitogen-activated protein kinase kinase 2 (EC:2.7.12.2)
hsa:5606 MAP2K3; mitogen-activated protein kinase kinase 3 (EC:2.7.12.2)
hsa:6416 MAP2K4; mitogen-activated protein kinase kinase 4 (EC:2.7.12.2)
hsa:5608 MAP2K6; mitogen-activated protein kinase kinase 6 (EC:2.7.12.2)
hsa:4216 MAP3K4; mitogen-activated protein kinase kinase kinase 4 (EC:2.7.11.25)
hsa:5594 MAPK1; mitogen-activated protein kinase 1 (EC:2.7.11.24)
hsa:1432 MAPK14; mitogen-activated protein kinase 14 (EC:2.7.11.24)
hsa:5595 MAPK3; mitogen-activated protein kinase 3 (EC:2.7.11.24)
hsa:5601 MAPK9; mitogen-activated protein kinase 9 (EC:2.7.11.24)
hsa:4323 MMP14; matrix metallopeptidase 14 (membrane-inserted) (EC:3.4.24.80)
hsa:4313 MMP2; matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24)
hsa:5321 PLA2G4A; phospholipase A2, group IVA (cytosolic, calcium-dependent) (EC:3.1.1.5 3.1.1.4)
hsa:5330 PLCB2; phospholipase C, beta 2 (EC:3.1.4.11)
hsa:5331 PLCB3; phospholipase C, beta 3 (phosphatidylinositol-specific) (EC:3.1.4.11)
hsa:5337 PLD1; phospholipase D1, phosphatidylcholine-specific (EC:3.1.4.4)
hsa:5578 PRKCA; protein kinase C, alpha (EC:2.7.11.13)
hsa:5579 PRKCB; protein kinase C, beta (EC:2.7.11.13)
hsa:2185 PTK2B; PTK2B protein tyrosine kinase 2 beta (EC:2.7.10.2)

hsa04610 Complement and coagulation cascades - Homo sapiens (human) (28)



hsa:2 A2M; alpha-2-macroglobulin
hsa:624 BDKRB2; bradykinin receptor B2
hsa:712 C1QA; complement component 1, q subcomponent, A chain
hsa:714 C1QC; complement component 1, q subcomponent, C chain
hsa:715 C1R; complement component 1, r subcomponent (EC:3.4.21.41)
hsa:716 C1S; complement component 1, s subcomponent (EC:3.4.21.42)
hsa:718 C3; complement component 3 (EC:3.4.21.43)
hsa:720 C4A; complement component 4A (Rodgers blood group)
hsa:721 C4B; complement component 4B (Chido blood group)
hsa:722 C4BPA; complement component 4 binding protein, alpha
hsa:727 C5; complement component 5
hsa:728 C5AR1; complement component 5a receptor 1
hsa:729 C6; complement component 6
hsa:730 C7; complement component 7
hsa:731 C8A; complement component 8, alpha polypeptide
hsa:732 C8B; complement component 8, beta polypeptide
hsa:1604 CD55; CD55 molecule, decay accelerating factor for complement (Cromer blood group)
hsa:966 CD59; CD59 molecule, complement regulatory protein
hsa:629 CFB; complement factor B (EC:3.4.21.47)
hsa:1378 CR1; complement component (3b/4b) receptor 1 (Knops blood group)
hsa:2162 F13A1; coagulation factor XIII, A1 polypeptide (EC:2.3.2.13)
hsa:5328 PLAU; plasminogen activator, urokinase (EC:3.4.21.73)
hsa:5329 PLAUR; plasminogen activator, urokinase receptor
hsa:5265 SERPINA1; serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
hsa:5054 SERPINE1; serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
hsa:710 SERPING1; serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
hsa:7035 TFPI; tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
hsa:7056 THBD; thrombomodulin

hsa04725 Cholinergic synapse - Homo sapiens (human) (28)



cpd:C00114 Choline
cpd:C00165 Diacylglycerol
cpd:C00238 Potassium cation
cpd:C00575 3',5'-Cyclic AMP
hsa:109 ADCY3; adenylate cyclase 3 (EC:4.6.1.1)
hsa:112 ADCY6; adenylate cyclase 6 (EC:4.6.1.1)
hsa:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1)
hsa:596 BCL2; B-cell CLL/lymphoma 2
hsa:1385 CREB1; cAMP responsive element binding protein 1
hsa:10488 CREB3; cAMP responsive element binding protein 3
hsa:9586 CREB5; cAMP responsive element binding protein 5
hsa:2353 FOS; FBJ murine osteosarcoma viral oncogene homolog
hsa:2534 FYN; FYN oncogene related to SRC, FGR, YES (EC:2.7.10.2)
hsa:59345 GNB4; guanine nucleotide binding protein (G protein), beta polypeptide 4
hsa:55970 GNG12; guanine nucleotide binding protein (G protein), gamma 12
hsa:2793 GNGT2; guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2
hsa:3708 ITPR1; inositol 1,4,5-trisphosphate receptor, type 1
hsa:3717 JAK2; Janus kinase 2 (EC:2.7.10.2)
hsa:3768 KCNJ12; potassium inwardly-rectifying channel, subfamily J, member 12
hsa:5594 MAPK1; mitogen-activated protein kinase 1 (EC:2.7.11.24)
hsa:5595 MAPK3; mitogen-activated protein kinase 3 (EC:2.7.11.24)
hsa:5290 PIK3CA; phosphoinositide-3-kinase, catalytic, alpha polypeptide (EC:2.7.11.1 2.7.1.153)
hsa:5291 PIK3CB; phosphoinositide-3-kinase, catalytic, beta polypeptide (EC:2.7.1.153)
hsa:5294 PIK3CG; phosphoinositide-3-kinase, catalytic, gamma polypeptide (EC:2.7.11.1 2.7.1.153)
hsa:5330 PLCB2; phospholipase C, beta 2 (EC:3.1.4.11)
hsa:5331 PLCB3; phospholipase C, beta 3 (phosphatidylinositol-specific) (EC:3.1.4.11)
hsa:5578 PRKCA; protein kinase C, alpha (EC:2.7.11.13)
hsa:5579 PRKCB; protein kinase C, beta (EC:2.7.11.13)

hsa04662 B cell receptor signaling pathway - Homo sapiens (human) (28)



cpd:C00165 Diacylglycerol
hsa:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1)
hsa:29760 BLNK; B-cell linker
hsa:933 CD22; CD22 molecule
hsa:1147 CHUK; conserved helix-loop-helix ubiquitous kinase (EC:2.7.11.10)
hsa:2213 FCGR2B; Fc fragment of IgG, low affinity IIb, receptor (CD32)
hsa:2353 FOS; FBJ murine osteosarcoma viral oncogene homolog
hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26)
hsa:8519 IFITM1; interferon induced transmembrane protein 1 (9-27)
hsa:3725 JUN; jun proto-oncogene
hsa:5605 MAP2K2; mitogen-activated protein kinase kinase 2 (EC:2.7.12.2)
hsa:5594 MAPK1; mitogen-activated protein kinase 1 (EC:2.7.11.24)
hsa:5595 MAPK3; mitogen-activated protein kinase 3 (EC:2.7.11.24)
hsa:4772 NFATC1; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
hsa:4790 NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
hsa:4792 NFKBIA; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
hsa:4793 NFKBIB; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
hsa:5290 PIK3CA; phosphoinositide-3-kinase, catalytic, alpha polypeptide (EC:2.7.11.1 2.7.1.153)
hsa:5291 PIK3CB; phosphoinositide-3-kinase, catalytic, beta polypeptide (EC:2.7.1.153)
hsa:5294 PIK3CG; phosphoinositide-3-kinase, catalytic, gamma polypeptide (EC:2.7.11.1 2.7.1.153)
hsa:5530 PPP3CA; protein phosphatase 3, catalytic subunit, alpha isozyme (EC:3.1.3.16)
hsa:5532 PPP3CB; protein phosphatase 3, catalytic subunit, beta isozyme (EC:3.1.3.16)
hsa:5533 PPP3CC; protein phosphatase 3, catalytic subunit, gamma isozyme (EC:3.1.3.16)
hsa:5534 PPP3R1; protein phosphatase 3, regulatory subunit B, alpha (EC:3.1.3.16)
hsa:5535 PPP3R2; protein phosphatase 3, regulatory subunit B, beta (EC:3.1.3.16)
hsa:5579 PRKCB; protein kinase C, beta (EC:2.7.11.13)
hsa:25780 RASGRP3; RAS guanyl releasing protein 3 (calcium and DAG-regulated)
hsa:5970 RELA; v-rel reticuloendotheliosis viral oncogene homolog A (avian)

hsa05031 Amphetamine addiction - Homo sapiens (human) (27)



cpd:C00027 Hydrogen peroxide
cpd:C00355 3,4-Dihydroxy-L-phenylalanine
cpd:C00575 3',5'-Cyclic AMP
cpd:C03758 Dopamine
hsa:23237 ARC; activity-regulated cytoskeleton-associated protein
hsa:1388 ATF6B; activating transcription factor 6 beta
hsa:805 CALM2; calmodulin 2 (phosphorylase kinase, delta) (EC:2.7.11.19)
hsa:808 CALM3; calmodulin 3 (phosphorylase kinase, delta) (EC:2.7.11.19)
hsa:1385 CREB1; cAMP responsive element binding protein 1
hsa:10488 CREB3; cAMP responsive element binding protein 3
hsa:9586 CREB5; cAMP responsive element binding protein 5
hsa:1644 DDC; dopa decarboxylase (aromatic L-amino acid decarboxylase) (EC:4.1.1.28)
hsa:1812 DRD1; dopamine receptor D1
hsa:2353 FOS; FBJ murine osteosarcoma viral oncogene homolog
hsa:2903 GRIN2A; glutamate receptor, ionotropic, N-methyl D-aspartate 2A
hsa:3725 JUN; jun proto-oncogene
hsa:4128 MAOA; monoamine oxidase A (EC:1.4.3.4)
hsa:5173 PDYN; prodynorphin
hsa:5530 PPP3CA; protein phosphatase 3, catalytic subunit, alpha isozyme (EC:3.1.3.16)
hsa:5532 PPP3CB; protein phosphatase 3, catalytic subunit, beta isozyme (EC:3.1.3.16)
hsa:5533 PPP3CC; protein phosphatase 3, catalytic subunit, gamma isozyme (EC:3.1.3.16)
hsa:5534 PPP3R1; protein phosphatase 3, regulatory subunit B, alpha (EC:3.1.3.16)
hsa:5535 PPP3R2; protein phosphatase 3, regulatory subunit B, beta (EC:3.1.3.16)
hsa:5578 PRKCA; protein kinase C, alpha (EC:2.7.11.13)
hsa:5579 PRKCB; protein kinase C, beta (EC:2.7.11.13)
hsa:6531 SLC6A3; solute carrier family 6 (neurotransmitter transporter, dopamine), member 3
hsa:7054 TH; tyrosine hydroxylase (EC:1.14.16.2)

hsa04142 Lysosome - Homo sapiens (human) (27)



cpd:C00002 ATP
cpd:C00159 D-Mannose
hsa:130340 AP1S3; adaptor-related protein complex 1, sigma 3 subunit
hsa:411 ARSB; arylsulfatase B (EC:3.1.6.12)
hsa:535 ATP6V0A1; ATPase, H+ transporting, lysosomal V0 subunit a1 (EC:3.6.3.14)
hsa:533 ATP6V0B; ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b (EC:3.6.3.14)
hsa:245972 ATP6V0D2; ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2 (EC:3.6.3.14)
hsa:968 CD68; CD68 molecule
hsa:1201 CLN3; ceroid-lipofuscinosis, neuronal 3
hsa:1211 CLTA; clathrin, light chain A
hsa:1508 CTSB; cathepsin B (EC:3.4.22.1)
hsa:1075 CTSC; cathepsin C (EC:3.4.14.1)
hsa:1509 CTSD; cathepsin D (EC:3.4.23.5)
hsa:1512 CTSH; cathepsin H (EC:3.4.22.16)
hsa:1515 CTSL2; cathepsin L2 (EC:3.4.22.43)
hsa:1777 DNASE2; deoxyribonuclease II, lysosomal (EC:3.1.22.1)
hsa:2990 GUSB; glucuronidase, beta (EC:3.2.1.31)
hsa:3074 HEXB; hexosaminidase B (beta polypeptide) (EC:3.2.1.52)
hsa:3916 LAMP1; lysosomal-associated membrane protein 1
hsa:27074 LAMP3; lysosomal-associated membrane protein 3
hsa:4668 NAGA; N-acetylgalactosaminidase, alpha- (EC:3.2.1.49)
hsa:10577 NPC2; Niemann-Pick disease, type C2
hsa:5538 PPT1; palmitoyl-protein thioesterase 1 (EC:3.1.2.22)
hsa:6556 SLC11A1; solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1
hsa:4891 SLC11A2; solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
hsa:6272 SORT1; sortilin 1
hsa:1200 TPP1; tripeptidyl peptidase I (EC:3.4.14.9)

hsa05012 Parkinson's disease - Homo sapiens (human) (27)



cpd:C00002 ATP
cpd:C00027 Hydrogen peroxide
cpd:C00355 3,4-Dihydroxy-L-phenylalanine
cpd:C03758 Dopamine
hsa:317 APAF1; apoptotic peptidase activating factor 1
hsa:498 ATP5A1; ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle
hsa:513 ATP5D; ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit (EC:3.6.1.14)
hsa:516 ATP5G1; ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)
hsa:4508 ATP6; ATP synthase F0 subunit 6
hsa:836 CASP3; caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56)
hsa:842 CASP9; caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62)
hsa:4514 COX3; cytochrome c oxidase III
hsa:1350 COX7C; cytochrome c oxidase subunit VIIc (EC:1.9.3.1)
hsa:54205 CYCS; cytochrome c, somatic
hsa:4519 CYTB; cytochrome b
hsa:4535 ND1; NADH dehydrogenase, subunit 1 (complex I)
hsa:4538 ND4; NADH dehydrogenase, subunit 4 (complex I)
hsa:4725 NDUFS5; NADH dehydrogenase (ubiquinone) Fe-S protein 5, 15kDa (NADH-coenzyme Q reductase)
hsa:374291 NDUFS7; NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase) (EC:1.6.5.3 1.6.99.3)
hsa:4731 NDUFV3; NADH dehydrogenase (ubiquinone) flavoprotein 3, 10kDa (EC:1.6.5.3)
hsa:11315 PARK7; parkinson protein 7
hsa:10105 PPIF; peptidylprolyl isomerase F (EC:5.2.1.8)
hsa:6531 SLC6A3; solute carrier family 6 (neurotransmitter transporter, dopamine), member 3
hsa:7054 TH; tyrosine hydroxylase (EC:1.14.16.2)
hsa:9246 UBE2L6; ubiquitin-conjugating enzyme E2L 6 (EC:6.3.2.19)
hsa:7345 UCHL1; ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) (EC:3.4.19.12)
hsa:7416 VDAC1; voltage-dependent anion channel 1

hsa05414 Dilated cardiomyopathy - Homo sapiens (human) (27)



cpd:C00575 3',5'-Cyclic AMP
hsa:60 ACTB; actin, beta
hsa:71 ACTG1; actin, gamma 1
hsa:109 ADCY3; adenylate cyclase 3 (EC:4.6.1.1)
hsa:112 ADCY6; adenylate cyclase 6 (EC:4.6.1.1)
hsa:1674 DES; desmin
hsa:3479 IGF1; insulin-like growth factor 1 (somatomedin C)
hsa:3673 ITGA2; integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
hsa:3676 ITGA4; integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
hsa:3678 ITGA5; integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
hsa:3655 ITGA6; integrin, alpha 6
hsa:8516 ITGA8; integrin, alpha 8
hsa:3680 ITGA9; integrin, alpha 9
hsa:3688 ITGB1; integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
hsa:3690 ITGB3; integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
hsa:3693 ITGB5; integrin, beta 5
hsa:3695 ITGB7; integrin, beta 7
hsa:4000 LMNA; lamin A/C
hsa:4624 MYH6; myosin, heavy chain 6, cardiac muscle, alpha
hsa:5350 PLN; phospholamban
hsa:7040 TGFB1; transforming growth factor, beta 1
hsa:7124 TNF; tumor necrosis factor
hsa:7137 TNNI3; troponin I type 3 (cardiac)
hsa:7168 TPM1; tropomyosin 1 (alpha)
hsa:7169 TPM2; tropomyosin 2 (beta)
hsa:7170 TPM3; tropomyosin 3
hsa:7171 TPM4; tropomyosin 4

hsa04270 Vascular smooth muscle contraction - Homo sapiens (human) (27)



cpd:C00165 Diacylglycerol
cpd:C00212 Adenosine
cpd:C00219 Arachidonate
cpd:C00238 Potassium cation
cpd:C00547 L-Noradrenaline
cpd:C00575 3',5'-Cyclic AMP
hsa:59 ACTA2; actin, alpha 2, smooth muscle, aorta
hsa:109 ADCY3; adenylate cyclase 3 (EC:4.6.1.1)
hsa:112 ADCY6; adenylate cyclase 6 (EC:4.6.1.1)
hsa:148 ADRA1A; adrenergic, alpha-1A-, receptor
hsa:800 CALD1; caldesmon 1
hsa:805 CALM2; calmodulin 2 (phosphorylase kinase, delta) (EC:2.7.11.19)
hsa:808 CALM3; calmodulin 3 (phosphorylase kinase, delta) (EC:2.7.11.19)
hsa:2768 GNA12; guanine nucleotide binding protein (G protein) alpha 12
hsa:3708 ITPR1; inositol 1,4,5-trisphosphate receptor, type 1
hsa:3778 KCNMA1; potassium large conductance calcium-activated channel, subfamily M, alpha member 1
hsa:10242 KCNMB2; potassium large conductance calcium-activated channel, subfamily M, beta member 2
hsa:27345 KCNMB4; potassium large conductance calcium-activated channel, subfamily M, beta member 4
hsa:5605 MAP2K2; mitogen-activated protein kinase kinase 2 (EC:2.7.12.2)
hsa:5594 MAPK1; mitogen-activated protein kinase 1 (EC:2.7.11.24)
hsa:5595 MAPK3; mitogen-activated protein kinase 3 (EC:2.7.11.24)
hsa:5321 PLA2G4A; phospholipase A2, group IVA (cytosolic, calcium-dependent) (EC:3.1.1.5 3.1.1.4)
hsa:5330 PLCB2; phospholipase C, beta 2 (EC:3.1.4.11)
hsa:5331 PLCB3; phospholipase C, beta 3 (phosphatidylinositol-specific) (EC:3.1.4.11)
hsa:5578 PRKCA; protein kinase C, alpha (EC:2.7.11.13)
hsa:5579 PRKCB; protein kinase C, beta (EC:2.7.11.13)
hsa:10266 RAMP2; receptor (G protein-coupled) activity modifying protein 2

hsa05120 Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human) (26)



gl:G00242 sialyl Lewis x antigen
hsa:102 ADAM10; ADAM metallopeptidase domain 10 (EC:3.4.24.81)
hsa:535 ATP6V0A1; ATPase, H+ transporting, lysosomal V0 subunit a1 (EC:3.6.3.14)
hsa:533 ATP6V0B; ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b (EC:3.6.3.14)
hsa:245972 ATP6V0D2; ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2 (EC:3.6.3.14)
hsa:523 ATP6V1A; ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A (EC:3.6.3.14)
hsa:836 CASP3; caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56)
hsa:6352 CCL5; chemokine (C-C motif) ligand 5
hsa:1147 CHUK; conserved helix-loop-helix ubiquitous kinase (EC:2.7.11.10)
hsa:2919 CXCL1; chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
hsa:3579 CXCR2; chemokine (C-X-C motif) receptor 2
hsa:1839 HBEGF; heparin-binding EGF-like growth factor
hsa:3576 IL8; interleukin 8
hsa:3725 JUN; jun proto-oncogene
hsa:6416 MAP2K4; mitogen-activated protein kinase kinase 4 (EC:2.7.12.2)
hsa:9020 MAP3K14; mitogen-activated protein kinase kinase kinase 14 (EC:2.7.11.25)
hsa:1432 MAPK14; mitogen-activated protein kinase 14 (EC:2.7.11.24)
hsa:5601 MAPK9; mitogen-activated protein kinase 9 (EC:2.7.11.24)
hsa:4790 NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
hsa:4792 NFKBIA; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
hsa:10392 NOD1; nucleotide-binding oligomerization domain containing 1
hsa:5335 PLCG1; phospholipase C, gamma 1 (EC:3.1.4.11)
hsa:5781 PTPN11; protein tyrosine phosphatase, non-receptor type 11 (EC:3.1.3.48)
hsa:5803 PTPRZ1; protein tyrosine phosphatase, receptor-type, Z polypeptide 1 (EC:3.1.3.48)
hsa:5970 RELA; v-rel reticuloendotheliosis viral oncogene homolog A (avian)
hsa:7082 TJP1; tight junction protein 1 (zona occludens 1)

hsa04012 ErbB signaling pathway - Homo sapiens (human) (26)



cpd:C00165 Diacylglycerol
hsa:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1)
hsa:572 BAD; BCL2-associated agonist of cell death
hsa:1026 CDKN1A; cyclin-dependent kinase inhibitor 1A (p21, Cip1)
hsa:1027 CDKN1B; cyclin-dependent kinase inhibitor 1B (p27, Kip1)
hsa:2064 ERBB2; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) (EC:2.7.10.1)
hsa:2069 EREG; epiregulin
hsa:2549 GAB1; GRB2-associated binding protein 1
hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26)
hsa:1839 HBEGF; heparin-binding EGF-like growth factor
hsa:3725 JUN; jun proto-oncogene
hsa:5605 MAP2K2; mitogen-activated protein kinase kinase 2 (EC:2.7.12.2)
hsa:6416 MAP2K4; mitogen-activated protein kinase kinase 4 (EC:2.7.12.2)
hsa:5594 MAPK1; mitogen-activated protein kinase 1 (EC:2.7.11.24)
hsa:5595 MAPK3; mitogen-activated protein kinase 3 (EC:2.7.11.24)
hsa:5601 MAPK9; mitogen-activated protein kinase 9 (EC:2.7.11.24)
hsa:2475 MTOR; mechanistic target of rapamycin (serine/threonine kinase) (EC:2.7.11.1)
hsa:4609 MYC; v-myc myelocytomatosis viral oncogene homolog (avian)
hsa:9542 NRG2; neuregulin 2
hsa:5290 PIK3CA; phosphoinositide-3-kinase, catalytic, alpha polypeptide (EC:2.7.11.1 2.7.1.153)
hsa:5291 PIK3CB; phosphoinositide-3-kinase, catalytic, beta polypeptide (EC:2.7.1.153)
hsa:5294 PIK3CG; phosphoinositide-3-kinase, catalytic, gamma polypeptide (EC:2.7.11.1 2.7.1.153)
hsa:5335 PLCG1; phospholipase C, gamma 1 (EC:3.1.4.11)
hsa:5578 PRKCA; protein kinase C, alpha (EC:2.7.11.13)
hsa:5579 PRKCB; protein kinase C, beta (EC:2.7.11.13)
hsa:6198 RPS6KB1; ribosomal protein S6 kinase, 70kDa, polypeptide 1 (EC:2.7.11.1)

hsa04612 Antigen processing and presentation - Homo sapiens (human) (26)



hsa:567 B2M; beta-2-microglobulin
hsa:811 CALR; calreticulin
hsa:821 CANX; calnexin
hsa:920 CD4; CD4 molecule
hsa:972 CD74; CD74 molecule, major histocompatibility complex, class II invariant chain
hsa:4261 CIITA; class II, major histocompatibility complex, transactivator
hsa:1385 CREB1; cAMP responsive element binding protein 1
hsa:1508 CTSB; cathepsin B (EC:3.4.22.1)
hsa:3105 HLA-A; major histocompatibility complex, class I, A
hsa:3107 HLA-C; major histocompatibility complex, class I, C
hsa:3109 HLA-DMB; major histocompatibility complex, class II, DM beta
hsa:3118 HLA-DQA2; major histocompatibility complex, class II, DQ alpha 2
hsa:3134 HLA-F; major histocompatibility complex, class I, F
hsa:3135 HLA-G; major histocompatibility complex, class I, G
hsa:3326 HSP90AB1; heat shock protein 90kDa alpha (cytosolic), class B member 1
hsa:3309 HSPA5; heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
hsa:3312 HSPA8; heat shock 70kDa protein 8
hsa:10437 IFI30; interferon, gamma-inducible protein 30
hsa:3458 IFNG; interferon, gamma
hsa:3824 KLRD1; killer cell lectin-like receptor subfamily D, member 1
hsa:5720 PSME1; proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
hsa:5721 PSME2; proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
hsa:6890 TAP1; transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
hsa:6891 TAP2; transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
hsa:6892 TAPBP; TAP binding protein (tapasin)
hsa:7124 TNF; tumor necrosis factor

hsa04970 Salivary secretion - Homo sapiens (human) (26)



cpd:C00165 Diacylglycerol
cpd:C00238 Potassium cation
cpd:C00533 Nitric oxide
cpd:C00547 L-Noradrenaline
cpd:C00575 3',5'-Cyclic AMP
cpd:C13050 Cyclic ADP-ribose
hsa:109 ADCY3; adenylate cyclase 3 (EC:4.6.1.1)
hsa:112 ADCY6; adenylate cyclase 6 (EC:4.6.1.1)
hsa:148 ADRA1A; adrenergic, alpha-1A-, receptor
hsa:155 ADRB3; adrenergic, beta-3-, receptor
hsa:481 ATP1B1; ATPase, Na+/K+ transporting, beta 1 polypeptide
hsa:482 ATP1B2; ATPase, Na+/K+ transporting, beta 2 polypeptide (EC:3.6.3.9)
hsa:483 ATP1B3; ATPase, Na+/K+ transporting, beta 3 polypeptide (EC:3.6.3.9)
hsa:493 ATP2B4; ATPase, Ca++ transporting, plasma membrane 4 (EC:3.6.3.8)
hsa:683 BST1; bone marrow stromal cell antigen 1 (EC:3.2.2.5)
hsa:805 CALM2; calmodulin 2 (phosphorylase kinase, delta) (EC:2.7.11.19)
hsa:808 CALM3; calmodulin 3 (phosphorylase kinase, delta) (EC:2.7.11.19)
hsa:952 CD38; CD38 molecule (EC:3.2.2.5)
hsa:3708 ITPR1; inositol 1,4,5-trisphosphate receptor, type 1
hsa:3778 KCNMA1; potassium large conductance calcium-activated channel, subfamily M, alpha member 1
hsa:4842 NOS1; nitric oxide synthase 1 (neuronal) (EC:1.14.13.39)
hsa:5330 PLCB2; phospholipase C, beta 2 (EC:3.1.4.11)
hsa:5331 PLCB3; phospholipase C, beta 3 (phosphatidylinositol-specific) (EC:3.1.4.11)
hsa:5578 PRKCA; protein kinase C, alpha (EC:2.7.11.13)
hsa:5579 PRKCB; protein kinase C, beta (EC:2.7.11.13)
hsa:6558 SLC12A2; solute carrier family 12 (sodium/potassium/chloride transporters), member 2

hsa05100 Bacterial invasion of epithelial cells - Homo sapiens (human) (26)



hsa:60 ACTB; actin, beta
hsa:71 ACTG1; actin, gamma 1
hsa:10552 ARPC1A; actin related protein 2/3 complex, subunit 1A, 41kDa
hsa:10095 ARPC1B; actin related protein 2/3 complex, subunit 1B, 41kDa
hsa:10109 ARPC2; actin related protein 2/3 complex, subunit 2, 34kDa
hsa:10094 ARPC3; actin related protein 2/3 complex, subunit 3, 21kDa
hsa:10093 ARPC4; actin related protein 2/3 complex, subunit 4, 20kDa
hsa:10092 ARPC5; actin related protein 2/3 complex, subunit 5, 16kDa
hsa:81873 ARPC5L; actin related protein 2/3 complex, subunit 5-like
hsa:9564 BCAR1; breast cancer anti-estrogen resistance 1
hsa:857 CAV1; caveolin 1, caveolae protein, 22kDa
hsa:858 CAV2; caveolin 2
hsa:23607 CD2AP; CD2-associated protein
hsa:1211 CLTA; clathrin, light chain A
hsa:2017 CTTN; cortactin
hsa:1759 DNM1; dynamin 1 (EC:3.6.5.5)
hsa:2335 FN1; fibronectin 1
hsa:2549 GAB1; GRB2-associated binding protein 1
hsa:3611 ILK; integrin-linked kinase (EC:2.7.11.1)
hsa:3678 ITGA5; integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
hsa:3688 ITGB1; integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
hsa:5290 PIK3CA; phosphoinositide-3-kinase, catalytic, alpha polypeptide (EC:2.7.11.1 2.7.1.153)
hsa:5291 PIK3CB; phosphoinositide-3-kinase, catalytic, beta polypeptide (EC:2.7.1.153)
hsa:5294 PIK3CG; phosphoinositide-3-kinase, catalytic, gamma polypeptide (EC:2.7.11.1 2.7.1.153)
hsa:391 RHOG; ras homolog family member G
hsa:7414 VCL; vinculin

hsa04976 Bile secretion - Homo sapiens (human) (25)



cpd:C00031 D-Glucose
cpd:C00051 Glutathione
cpd:C00114 Choline
cpd:C00238 Potassium cation
cpd:C00315 Spermidine
cpd:C00504 Folate
cpd:C00575 3',5'-Cyclic AMP
cpd:C00584 Prostaglandin E2
cpd:C00750 Spermine
cpd:C01829 Thyroxine
cpd:C02165 Leukotriene B4
cpd:C02166 Leukotriene C4
cpd:C03758 Dopamine
hsa:5243 ABCB1; ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44)
hsa:5244 ABCB4; ATP-binding cassette, sub-family B (MDR/TAP), member 4 (EC:3.6.3.44)
hsa:109 ADCY3; adenylate cyclase 3 (EC:4.6.1.1)
hsa:112 ADCY6; adenylate cyclase 6 (EC:4.6.1.1)
hsa:358 AQP1; aquaporin 1 (Colton blood group)
hsa:366 AQP9; aquaporin 9
hsa:481 ATP1B1; ATPase, Na+/K+ transporting, beta 1 polypeptide
hsa:482 ATP1B2; ATPase, Na+/K+ transporting, beta 2 polypeptide (EC:3.6.3.9)
hsa:483 ATP1B3; ATPase, Na+/K+ transporting, beta 3 polypeptide (EC:3.6.3.9)
hsa:3156 HMGCR; 3-hydroxy-3-methylglutaryl-CoA reductase (EC:1.1.1.34)
hsa:3949 LDLR; low density lipoprotein receptor
hsa:6579 SLCO1A2; solute carrier organic anion transporter family, member 1A2

hsa04723 Retrograde endocannabinoid signaling - Homo sapiens (human) (25)



cpd:C00157 Phosphatidylcholine
cpd:C00165 Diacylglycerol
cpd:C00189 Ethanolamine
cpd:C00219 Arachidonate
cpd:C00238 Potassium cation
cpd:C00350 Phosphatidylethanolamine
cpd:C00575 3',5'-Cyclic AMP
hsa:109 ADCY3; adenylate cyclase 3 (EC:4.6.1.1)
hsa:112 ADCY6; adenylate cyclase 6 (EC:4.6.1.1)
hsa:221955 DAGLB; diacylglycerol lipase, beta (EC:3.1.1.-)
hsa:2562 GABRB3; gamma-aminobutyric acid (GABA) A receptor, beta 3
hsa:59345 GNB4; guanine nucleotide binding protein (G protein), beta polypeptide 4
hsa:55970 GNG12; guanine nucleotide binding protein (G protein), gamma 12
hsa:2793 GNGT2; guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2
hsa:3708 ITPR1; inositol 1,4,5-trisphosphate receptor, type 1
hsa:5594 MAPK1; mitogen-activated protein kinase 1 (EC:2.7.11.24)
hsa:1432 MAPK14; mitogen-activated protein kinase 14 (EC:2.7.11.24)
hsa:5595 MAPK3; mitogen-activated protein kinase 3 (EC:2.7.11.24)
hsa:5601 MAPK9; mitogen-activated protein kinase 9 (EC:2.7.11.24)
hsa:11343 MGLL; monoglyceride lipase (EC:3.1.1.23)
hsa:5330 PLCB2; phospholipase C, beta 2 (EC:3.1.4.11)
hsa:5331 PLCB3; phospholipase C, beta 3 (phosphatidylinositol-specific) (EC:3.1.4.11)
hsa:5578 PRKCA; protein kinase C, alpha (EC:2.7.11.13)
hsa:5579 PRKCB; protein kinase C, beta (EC:2.7.11.13)
hsa:5743 PTGS2; prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1)

hsa04940 Type I diabetes mellitus - Homo sapiens (human) (25)



cpd:C00027 Hydrogen peroxide
cpd:C00533 Nitric oxide
hsa:940 CD28; CD28 molecule
hsa:941 CD80; CD80 molecule
hsa:942 CD86; CD86 molecule
hsa:1363 CPE; carboxypeptidase E (EC:3.4.17.10)
hsa:355 FAS; Fas (TNF receptor superfamily, member 6)
hsa:3002 GZMB; granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) (EC:3.4.21.79)
hsa:3105 HLA-A; major histocompatibility complex, class I, A
hsa:3107 HLA-C; major histocompatibility complex, class I, C
hsa:3109 HLA-DMB; major histocompatibility complex, class II, DM beta
hsa:3118 HLA-DQA2; major histocompatibility complex, class II, DQ alpha 2
hsa:3134 HLA-F; major histocompatibility complex, class I, F
hsa:3135 HLA-G; major histocompatibility complex, class I, G
hsa:3329 HSPD1; heat shock 60kDa protein 1 (chaperonin)
hsa:3458 IFNG; interferon, gamma
hsa:3592 IL12A; interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)
hsa:3593 IL12B; interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)
hsa:3552 IL1A; interleukin 1, alpha
hsa:3553 IL1B; interleukin 1, beta
hsa:3558 IL2; interleukin 2
hsa:3630 INS; insulin
hsa:4049 LTA; lymphotoxin alpha (TNF superfamily, member 1)
hsa:5551 PRF1; perforin 1 (pore forming protein)
hsa:7124 TNF; tumor necrosis factor

hsa05410 Hypertrophic cardiomyopathy (HCM) - Homo sapiens (human) (25)



cpd:C00002 ATP
hsa:60 ACTB; actin, beta
hsa:71 ACTG1; actin, gamma 1
hsa:1674 DES; desmin
hsa:3479 IGF1; insulin-like growth factor 1 (somatomedin C)
hsa:3569 IL6; interleukin 6 (interferon, beta 2)
hsa:3673 ITGA2; integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
hsa:3676 ITGA4; integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
hsa:3678 ITGA5; integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
hsa:3655 ITGA6; integrin, alpha 6
hsa:8516 ITGA8; integrin, alpha 8
hsa:3680 ITGA9; integrin, alpha 9
hsa:3688 ITGB1; integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
hsa:3690 ITGB3; integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
hsa:3693 ITGB5; integrin, beta 5
hsa:3695 ITGB7; integrin, beta 7
hsa:4000 LMNA; lamin A/C
hsa:4624 MYH6; myosin, heavy chain 6, cardiac muscle, alpha
hsa:7040 TGFB1; transforming growth factor, beta 1
hsa:7124 TNF; tumor necrosis factor
hsa:7137 TNNI3; troponin I type 3 (cardiac)
hsa:7168 TPM1; tropomyosin 1 (alpha)
hsa:7169 TPM2; tropomyosin 2 (beta)
hsa:7170 TPM3; tropomyosin 3
hsa:7171 TPM4; tropomyosin 4

hsa04920 Adipocytokine signaling pathway - Homo sapiens (human) (25)



cpd:C00165 Diacylglycerol
cpd:C00195 N-Acylsphingosine
hsa:2180 ACSL1; acyl-CoA synthetase long-chain family member 1 (EC:6.2.1.3)
hsa:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1)
hsa:948 CD36; CD36 molecule (thrombospondin receptor)
hsa:1147 CHUK; conserved helix-loop-helix ubiquitous kinase (EC:2.7.11.10)
hsa:1374 CPT1A; carnitine palmitoyltransferase 1A (liver) (EC:2.3.1.21)
hsa:126129 CPT1C; carnitine palmitoyltransferase 1C (EC:2.3.1.21)
hsa:2538 G6PC; glucose-6-phosphatase, catalytic subunit (EC:3.1.3.9)
hsa:3717 JAK2; Janus kinase 2 (EC:2.7.10.2)
hsa:5601 MAPK9; mitogen-activated protein kinase 9 (EC:2.7.11.24)
hsa:2475 MTOR; mechanistic target of rapamycin (serine/threonine kinase) (EC:2.7.11.1)
hsa:4790 NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
hsa:4792 NFKBIA; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
hsa:4793 NFKBIB; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
hsa:4852 NPY; neuropeptide Y
hsa:5105 PCK1; phosphoenolpyruvate carboxykinase 1 (soluble) (EC:4.1.1.32)
hsa:5465 PPARA; peroxisome proliferator-activated receptor alpha
hsa:5781 PTPN11; protein tyrosine phosphatase, non-receptor type 11 (EC:3.1.3.48)
hsa:5970 RELA; v-rel reticuloendotheliosis viral oncogene homolog A (avian)
hsa:9021 SOCS3; suppressor of cytokine signaling 3
hsa:7124 TNF; tumor necrosis factor
hsa:7132 TNFRSF1A; tumor necrosis factor receptor superfamily, member 1A
hsa:7133 TNFRSF1B; tumor necrosis factor receptor superfamily, member 1B
hsa:8717 TRADD; TNFRSF1A-associated via death domain

hsa04916 Melanogenesis - Homo sapiens (human) (25)



cpd:C00165 Diacylglycerol
cpd:C00575 3',5'-Cyclic AMP
ec:5.3.3.12 dopachrome isomerase;(a property of MIF) 
hsa:109 ADCY3; adenylate cyclase 3 (EC:4.6.1.1)
hsa:112 ADCY6; adenylate cyclase 6 (EC:4.6.1.1)
hsa:805 CALM2; calmodulin 2 (phosphorylase kinase, delta) (EC:2.7.11.19)
hsa:808 CALM3; calmodulin 3 (phosphorylase kinase, delta) (EC:2.7.11.19)
hsa:1385 CREB1; cAMP responsive element binding protein 1
hsa:10488 CREB3; cAMP responsive element binding protein 3
hsa:1638 DCT; dopachrome tautomerase (dopachrome delta-isomerase, tyrosine-related protein 2) (EC:5.3.3.12)
hsa:1906 EDN1; endothelin 1
hsa:1910 EDNRB; endothelin receptor type B
hsa:8322 FZD4; frizzled family receptor 4
hsa:8324 FZD7; frizzled family receptor 7
hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26)
hsa:4254 KITLG; KIT ligand
hsa:5605 MAP2K2; mitogen-activated protein kinase kinase 2 (EC:2.7.12.2)
hsa:5594 MAPK1; mitogen-activated protein kinase 1 (EC:2.7.11.24)
hsa:5595 MAPK3; mitogen-activated protein kinase 3 (EC:2.7.11.24)
hsa:5330 PLCB2; phospholipase C, beta 2 (EC:3.1.4.11)
hsa:5331 PLCB3; phospholipase C, beta 3 (phosphatidylinositol-specific) (EC:3.1.4.11)
hsa:5578 PRKCA; protein kinase C, alpha (EC:2.7.11.13)
hsa:5579 PRKCB; protein kinase C, beta (EC:2.7.11.13)
hsa:6934 TCF7L2; transcription factor 7-like 2 (T-cell specific, HMG-box)
hsa:7474 WNT5A; wingless-type MMTV integration site family, member 5A

hsa04115 p53 signaling pathway - Homo sapiens (human) (25)



hsa:317 APAF1; apoptotic peptidase activating factor 1
hsa:472 ATM; ataxia telangiectasia mutated (EC:2.7.11.1)
hsa:581 BAX; BCL2-associated X protein
hsa:637 BID; BH3 interacting domain death agonist
hsa:836 CASP3; caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56)
hsa:841 CASP8; caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61)
hsa:842 CASP9; caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62)
hsa:891 CCNB1; cyclin B1
hsa:595 CCND1; cyclin D1
hsa:3732 CD82; CD82 molecule
hsa:1017 CDK2; cyclin-dependent kinase 2 (EC:2.7.11.22)
hsa:1026 CDKN1A; cyclin-dependent kinase inhibitor 1A (p21, Cip1)
hsa:54205 CYCS; cytochrome c, somatic
hsa:1643 DDB2; damage-specific DNA binding protein 2, 48kDa
hsa:355 FAS; Fas (TNF receptor superfamily, member 6)
hsa:1647 GADD45A; growth arrest and DNA-damage-inducible, alpha
hsa:4616 GADD45B; growth arrest and DNA-damage-inducible, beta
hsa:3479 IGF1; insulin-like growth factor 1 (somatomedin C)
hsa:3486 IGFBP3; insulin-like growth factor binding protein 3
hsa:5366 PMAIP1; phorbol-12-myristate-13-acetate-induced protein 1
hsa:50484 RRM2B; ribonucleotide reductase M2 B (TP53 inducible) (EC:1.17.4.1)
hsa:5054 SERPINE1; serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
hsa:27244 SESN1; sestrin 1
hsa:2810 SFN; stratifin
hsa:7057 THBS1; thrombospondin 1

hsa04370 VEGF signaling pathway - Homo sapiens (human) (24)



cpd:C00165 Diacylglycerol
cpd:C00533 Nitric oxide
hsa:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1)
hsa:572 BAD; BCL2-associated agonist of cell death
hsa:842 CASP9; caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62)
hsa:3315 HSPB1; heat shock 27kDa protein 1
hsa:5605 MAP2K2; mitogen-activated protein kinase kinase 2 (EC:2.7.12.2)
hsa:5594 MAPK1; mitogen-activated protein kinase 1 (EC:2.7.11.24)
hsa:1432 MAPK14; mitogen-activated protein kinase 14 (EC:2.7.11.24)
hsa:5595 MAPK3; mitogen-activated protein kinase 3 (EC:2.7.11.24)
hsa:4772 NFATC1; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
hsa:5290 PIK3CA; phosphoinositide-3-kinase, catalytic, alpha polypeptide (EC:2.7.11.1 2.7.1.153)
hsa:5291 PIK3CB; phosphoinositide-3-kinase, catalytic, beta polypeptide (EC:2.7.1.153)
hsa:5294 PIK3CG; phosphoinositide-3-kinase, catalytic, gamma polypeptide (EC:2.7.11.1 2.7.1.153)
hsa:5321 PLA2G4A; phospholipase A2, group IVA (cytosolic, calcium-dependent) (EC:3.1.1.5 3.1.1.4)
hsa:5335 PLCG1; phospholipase C, gamma 1 (EC:3.1.4.11)
hsa:5530 PPP3CA; protein phosphatase 3, catalytic subunit, alpha isozyme (EC:3.1.3.16)
hsa:5532 PPP3CB; protein phosphatase 3, catalytic subunit, beta isozyme (EC:3.1.3.16)
hsa:5533 PPP3CC; protein phosphatase 3, catalytic subunit, gamma isozyme (EC:3.1.3.16)
hsa:5534 PPP3R1; protein phosphatase 3, regulatory subunit B, alpha (EC:3.1.3.16)
hsa:5535 PPP3R2; protein phosphatase 3, regulatory subunit B, beta (EC:3.1.3.16)
hsa:5578 PRKCA; protein kinase C, alpha (EC:2.7.11.13)
hsa:5579 PRKCB; protein kinase C, beta (EC:2.7.11.13)
hsa:5743 PTGS2; prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1)

hsa00330 Arginine and proline metabolism - Homo sapiens (human) (24)



cpd:C00062 L-Arginine
cpd:C00064 L-Glutamine
cpd:C00077 L-Ornithine
cpd:C00134 Putrescine
cpd:C00315 Spermidine
cpd:C00533 Nitric oxide
cpd:C00750 Spermine
hsa:219 ALDH1B1; aldehyde dehydrogenase 1 family, member B1 (EC:1.2.1.3)
hsa:501 ALDH7A1; aldehyde dehydrogenase 7 family, member A1 (EC:1.2.1.3 1.2.1.8 1.2.1.31)
hsa:223 ALDH9A1; aldehyde dehydrogenase 9 family, member A1 (EC:1.2.1.3 1.2.1.19 1.2.1.47)
hsa:383 ARG1; arginase, liver (EC:3.5.3.1)
hsa:384 ARG2; arginase, type II (EC:3.5.3.1)
hsa:445 ASS1; argininosuccinate synthase 1 (EC:6.3.4.5)
hsa:55748 CNDP2; CNDP dipeptidase 2 (metallopeptidase M20 family) (EC:3.4.13.18)
hsa:2593 GAMT; guanidinoacetate N-methyltransferase (EC:2.1.1.2)
hsa:2744 GLS; glutaminase (EC:3.5.1.2)
hsa:27165 GLS2; glutaminase 2 (liver, mitochondrial) (EC:3.5.1.2)
hsa:2752 GLUL; glutamate-ammonia ligase (EC:4.1.1.15 6.3.1.2)
hsa:51056 LAP3; leucine aminopeptidase 3 (EC:3.4.11.5 3.4.11.1)
hsa:4128 MAOA; monoamine oxidase A (EC:1.4.3.4)
hsa:4842 NOS1; nitric oxide synthase 1 (neuronal) (EC:1.14.13.39)
hsa:4843 NOS2; nitric oxide synthase 2, inducible (EC:1.14.13.39)
hsa:5009 OTC; ornithine carbamoyltransferase (EC:2.1.3.3)
hsa:6723 SRM; spermidine synthase (EC:2.5.1.16)

hsa04360 Axon guidance - Homo sapiens (human) (24)



hsa:3983 ABLIM1; actin binding LIM protein 1
hsa:1072 CFL1; cofilin 1 (non-muscle)
hsa:6387 CXCL12; chemokine (C-X-C motif) ligand 12
hsa:7852 CXCR4; chemokine (C-X-C motif) receptor 4
hsa:1808 DPYSL2; dihydropyrimidinase-like 2
hsa:1947 EFNB1; ephrin-B1
hsa:2534 FYN; FYN oncogene related to SRC, FGR, YES (EC:2.7.10.2)
hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26)
hsa:3688 ITGB1; integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
hsa:5594 MAPK1; mitogen-activated protein kinase 1 (EC:2.7.11.24)
hsa:5595 MAPK3; mitogen-activated protein kinase 3 (EC:2.7.11.24)
hsa:4772 NFATC1; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
hsa:5361 PLXNA1; plexin A1
hsa:5362 PLXNA2; plexin A2
hsa:55558 PLXNA3; plexin A3
hsa:10154 PLXNC1; plexin C1
hsa:5530 PPP3CA; protein phosphatase 3, catalytic subunit, alpha isozyme (EC:3.1.3.16)
hsa:5532 PPP3CB; protein phosphatase 3, catalytic subunit, beta isozyme (EC:3.1.3.16)
hsa:5533 PPP3CC; protein phosphatase 3, catalytic subunit, gamma isozyme (EC:3.1.3.16)
hsa:5534 PPP3R1; protein phosphatase 3, regulatory subunit B, alpha (EC:3.1.3.16)
hsa:5535 PPP3R2; protein phosphatase 3, regulatory subunit B, beta (EC:3.1.3.16)
hsa:64218 SEMA4A; sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
hsa:8482 SEMA7A; semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)
hsa:6585 SLIT1; slit homolog 1 (Drosophila)

hsa05143 African trypanosomiasis - Homo sapiens (human) (24)



cpd:C00078 L-Tryptophan
cpd:C00165 Diacylglycerol
cpd:C00328 L-Kynurenine
cpd:C00533 Nitric oxide
cpd:C00584 Prostaglandin E2
hsa:355 FAS; Fas (TNF receptor superfamily, member 6)
hsa:3383 ICAM1; intercellular adhesion molecule 1
hsa:3620 IDO1; indoleamine 2,3-dioxygenase 1 (EC:1.13.11.52)
hsa:3458 IFNG; interferon, gamma
hsa:3586 IL10; interleukin 10
hsa:3592 IL12A; interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)
hsa:3593 IL12B; interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)
hsa:3606 IL18; interleukin 18 (interferon-gamma-inducing factor)
hsa:3553 IL1B; interleukin 1, beta
hsa:3569 IL6; interleukin 6 (interferon, beta 2)
hsa:3910 LAMA4; laminin, alpha 4
hsa:4615 MYD88; myeloid differentiation primary response gene (88)
hsa:5330 PLCB2; phospholipase C, beta 2 (EC:3.1.4.11)
hsa:5331 PLCB3; phospholipase C, beta 3 (phosphatidylinositol-specific) (EC:3.1.4.11)
hsa:5578 PRKCA; protein kinase C, alpha (EC:2.7.11.13)
hsa:5579 PRKCB; protein kinase C, beta (EC:2.7.11.13)
hsa:54106 TLR9; toll-like receptor 9
hsa:7124 TNF; tumor necrosis factor
hsa:7412 VCAM1; vascular cell adhesion molecule 1

hsa05150 Staphylococcus aureus infection - Homo sapiens (human) (24)



hsa:712 C1QA; complement component 1, q subcomponent, A chain
hsa:714 C1QC; complement component 1, q subcomponent, C chain
hsa:715 C1R; complement component 1, r subcomponent (EC:3.4.21.41)
hsa:716 C1S; complement component 1, s subcomponent (EC:3.4.21.42)
hsa:718 C3; complement component 3 (EC:3.4.21.43)
hsa:720 C4A; complement component 4A (Rodgers blood group)
hsa:721 C4B; complement component 4B (Chido blood group)
hsa:727 C5; complement component 5
hsa:728 C5AR1; complement component 5a receptor 1
hsa:629 CFB; complement factor B (EC:3.4.21.47)
hsa:2209 FCGR1A; Fc fragment of IgG, high affinity Ia, receptor (CD64)
hsa:2213 FCGR2B; Fc fragment of IgG, low affinity IIb, receptor (CD32)
hsa:2214 FCGR3A; Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
hsa:2215 FCGR3B; Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
hsa:2358 FPR2; formyl peptide receptor 2
hsa:3109 HLA-DMB; major histocompatibility complex, class II, DM beta
hsa:3118 HLA-DQA2; major histocompatibility complex, class II, DQ alpha 2
hsa:3383 ICAM1; intercellular adhesion molecule 1
hsa:3586 IL10; interleukin 10
hsa:3683 ITGAL; integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
hsa:3684 ITGAM; integrin, alpha M (complement component 3 receptor 3 subunit)
hsa:3689 ITGB2; integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
hsa:3858 KRT10; keratin 10
hsa:5724 PTAFR; platelet-activating factor receptor

hsa00010 Glycolysis / Gluconeogenesis - Homo sapiens (human) (23)



cpd:C00031 D-Glucose
hsa:219 ALDH1B1; aldehyde dehydrogenase 1 family, member B1 (EC:1.2.1.3)
hsa:501 ALDH7A1; aldehyde dehydrogenase 7 family, member A1 (EC:1.2.1.3 1.2.1.8 1.2.1.31)
hsa:223 ALDH9A1; aldehyde dehydrogenase 9 family, member A1 (EC:1.2.1.3 1.2.1.19 1.2.1.47)
hsa:226 ALDOA; aldolase A, fructose-bisphosphate (EC:4.1.2.13)
hsa:229 ALDOB; aldolase B, fructose-bisphosphate (EC:4.1.2.13)
hsa:2023 ENO1; enolase 1, (alpha) (EC:4.2.1.11)
hsa:2538 G6PC; glucose-6-phosphatase, catalytic subunit (EC:3.1.3.9)
hsa:2597 GAPDH; glyceraldehyde-3-phosphate dehydrogenase (EC:1.2.1.12)
hsa:2821 GPI; glucose-6-phosphate isomerase (EC:5.3.1.9)
hsa:3098 HK1; hexokinase 1 (EC:2.7.1.1)
hsa:3099 HK2; hexokinase 2 (EC:2.7.1.1)
hsa:3101 HK3; hexokinase 3 (white cell) (EC:2.7.1.1)
hsa:3939 LDHA; lactate dehydrogenase A (EC:1.1.1.27)
hsa:5105 PCK1; phosphoenolpyruvate carboxykinase 1 (soluble) (EC:4.1.1.32)
hsa:5211 PFKL; phosphofructokinase, liver (EC:2.7.1.11)
hsa:5214 PFKP; phosphofructokinase, platelet (EC:2.7.1.11)
hsa:5223 PGAM1; phosphoglycerate mutase 1 (brain) (EC:3.1.3.13 5.4.2.1 5.4.2.4)
hsa:5224 PGAM2; phosphoglycerate mutase 2 (muscle) (EC:3.1.3.13 5.4.2.1 5.4.2.4)
hsa:5230 PGK1; phosphoglycerate kinase 1 (EC:2.7.2.3)
hsa:55276 PGM2; phosphoglucomutase 2 (EC:5.4.2.2 5.4.2.7)
hsa:5315 PKM2; pyruvate kinase, muscle (EC:2.7.1.40)
hsa:7167 TPI1; triosephosphate isomerase 1 (EC:5.3.1.1)

hsa05330 Allograft rejection - Homo sapiens (human) (23)



cpd:C00533 Nitric oxide
hsa:940 CD28; CD28 molecule
hsa:958 CD40; CD40 molecule, TNF receptor superfamily member 5
hsa:959 CD40LG; CD40 ligand
hsa:941 CD80; CD80 molecule
hsa:942 CD86; CD86 molecule
hsa:355 FAS; Fas (TNF receptor superfamily, member 6)
hsa:3002 GZMB; granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) (EC:3.4.21.79)
hsa:3105 HLA-A; major histocompatibility complex, class I, A
hsa:3107 HLA-C; major histocompatibility complex, class I, C
hsa:3109 HLA-DMB; major histocompatibility complex, class II, DM beta
hsa:3118 HLA-DQA2; major histocompatibility complex, class II, DQ alpha 2
hsa:3134 HLA-F; major histocompatibility complex, class I, F
hsa:3135 HLA-G; major histocompatibility complex, class I, G
hsa:3458 IFNG; interferon, gamma
hsa:3586 IL10; interleukin 10
hsa:3592 IL12A; interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)
hsa:3593 IL12B; interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)
hsa:3558 IL2; interleukin 2
hsa:3565 IL4; interleukin 4
hsa:3567 IL5; interleukin 5 (colony-stimulating factor, eosinophil)
hsa:5551 PRF1; perforin 1 (pore forming protein)
hsa:7124 TNF; tumor necrosis factor

hsa05210 Colorectal cancer - Homo sapiens (human) (23)



hsa:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1)
hsa:8313 AXIN2; axin 2
hsa:572 BAD; BCL2-associated agonist of cell death
hsa:581 BAX; BCL2-associated X protein
hsa:596 BCL2; B-cell CLL/lymphoma 2
hsa:836 CASP3; caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56)
hsa:842 CASP9; caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62)
hsa:595 CCND1; cyclin D1
hsa:54205 CYCS; cytochrome c, somatic
hsa:2353 FOS; FBJ murine osteosarcoma viral oncogene homolog
hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26)
hsa:3725 JUN; jun proto-oncogene
hsa:5594 MAPK1; mitogen-activated protein kinase 1 (EC:2.7.11.24)
hsa:5595 MAPK3; mitogen-activated protein kinase 3 (EC:2.7.11.24)
hsa:5601 MAPK9; mitogen-activated protein kinase 9 (EC:2.7.11.24)
hsa:4609 MYC; v-myc myelocytomatosis viral oncogene homolog (avian)
hsa:5290 PIK3CA; phosphoinositide-3-kinase, catalytic, alpha polypeptide (EC:2.7.11.1 2.7.1.153)
hsa:5291 PIK3CB; phosphoinositide-3-kinase, catalytic, beta polypeptide (EC:2.7.1.153)
hsa:5294 PIK3CG; phosphoinositide-3-kinase, catalytic, gamma polypeptide (EC:2.7.11.1 2.7.1.153)
hsa:4087 SMAD2; SMAD family member 2
hsa:6934 TCF7L2; transcription factor 7-like 2 (T-cell specific, HMG-box)
hsa:7040 TGFB1; transforming growth factor, beta 1
hsa:7046 TGFBR1; transforming growth factor, beta receptor 1 (EC:2.7.11.30)

hsa04972 Pancreatic secretion - Homo sapiens (human) (23)



cpd:C00165 Diacylglycerol
cpd:C00238 Potassium cation
cpd:C00575 3',5'-Cyclic AMP
cpd:C13050 Cyclic ADP-ribose
hsa:109 ADCY3; adenylate cyclase 3 (EC:4.6.1.1)
hsa:112 ADCY6; adenylate cyclase 6 (EC:4.6.1.1)
hsa:279 AMY2A; amylase, alpha 2A (pancreatic) (EC:3.2.1.1)
hsa:481 ATP1B1; ATPase, Na+/K+ transporting, beta 1 polypeptide
hsa:482 ATP1B2; ATPase, Na+/K+ transporting, beta 2 polypeptide (EC:3.6.3.9)
hsa:483 ATP1B3; ATPase, Na+/K+ transporting, beta 3 polypeptide (EC:3.6.3.9)
hsa:493 ATP2B4; ATPase, Ca++ transporting, plasma membrane 4 (EC:3.6.3.8)
hsa:683 BST1; bone marrow stromal cell antigen 1 (EC:3.2.2.5)
hsa:952 CD38; CD38 molecule (EC:3.2.2.5)
hsa:3708 ITPR1; inositol 1,4,5-trisphosphate receptor, type 1
hsa:3778 KCNMA1; potassium large conductance calcium-activated channel, subfamily M, alpha member 1
hsa:5321 PLA2G4A; phospholipase A2, group IVA (cytosolic, calcium-dependent) (EC:3.1.1.5 3.1.1.4)
hsa:5330 PLCB2; phospholipase C, beta 2 (EC:3.1.4.11)
hsa:5331 PLCB3; phospholipase C, beta 3 (phosphatidylinositol-specific) (EC:3.1.4.11)
hsa:5578 PRKCA; protein kinase C, alpha (EC:2.7.11.13)
hsa:5579 PRKCB; protein kinase C, beta (EC:2.7.11.13)
hsa:5644 PRSS1; protease, serine, 1 (trypsin 1) (EC:3.4.21.4)
hsa:9545 RAB3D; RAB3D, member RAS oncogene family
hsa:6558 SLC12A2; solute carrier family 12 (sodium/potassium/chloride transporters), member 2

hsa04622 RIG-I-like receptor signaling pathway - Homo sapiens (human) (23)



hsa:9474 ATG5; ATG5 autophagy related 5 homolog (S. cerevisiae)
hsa:841 CASP8; caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61)
hsa:1147 CHUK; conserved helix-loop-helix ubiquitous kinase (EC:2.7.11.10)
hsa:3627 CXCL10; chemokine (C-X-C motif) ligand 10
hsa:26007 DAK; dihydroxyacetone kinase 2 homolog (S. cerevisiae) (EC:2.7.1.29 4.6.1.15)
hsa:8772 FADD; Fas (TNFRSF6)-associated via death domain
hsa:3439 IFNA1; interferon, alpha 1
hsa:3443 IFNA6; interferon, alpha 6
hsa:3592 IL12A; interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)
hsa:3593 IL12B; interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)
hsa:3576 IL8; interleukin 8
hsa:9636 ISG15; ISG15 ubiquitin-like modifier
hsa:6885 MAP3K7; mitogen-activated protein kinase kinase kinase 7 (EC:2.7.11.25)
hsa:1432 MAPK14; mitogen-activated protein kinase 14 (EC:2.7.11.24)
hsa:5601 MAPK9; mitogen-activated protein kinase 9 (EC:2.7.11.24)
hsa:4790 NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
hsa:4792 NFKBIA; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
hsa:4793 NFKBIB; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
hsa:5970 RELA; v-rel reticuloendotheliosis viral oncogene homolog A (avian)
hsa:340061 TMEM173; transmembrane protein 173
hsa:7124 TNF; tumor necrosis factor
hsa:8717 TRADD; TNFRSF1A-associated via death domain
hsa:7189 TRAF6; TNF receptor-associated factor 6, E3 ubiquitin protein ligase

hsa02010 ABC transporters - Homo sapiens (human) (23)



cpd:C00031 D-Glucose
cpd:C00038 Zinc cation
cpd:C00051 Glutathione
cpd:C00062 L-Arginine
cpd:C00064 L-Glutamine
cpd:C00065 L-Serine
cpd:C00077 L-Ornithine
cpd:C00114 Choline
cpd:C00134 Putrescine
cpd:C00243 Lactose
cpd:C00315 Spermidine
cpd:C00338 Lipopolysaccharide
hsa:19 ABCA1; ATP-binding cassette, sub-family A (ABC1), member 1
hsa:154664 ABCA13; ATP-binding cassette, sub-family A (ABC1), member 13
hsa:24 ABCA4; ATP-binding cassette, sub-family A (ABC1), member 4
hsa:23461 ABCA5; ATP-binding cassette, sub-family A (ABC1), member 5
hsa:5243 ABCB1; ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44)
hsa:5244 ABCB4; ATP-binding cassette, sub-family B (MDR/TAP), member 4 (EC:3.6.3.44)
hsa:340273 ABCB5; ATP-binding cassette, sub-family B (MDR/TAP), member 5
hsa:11194 ABCB8; ATP-binding cassette, sub-family B (MDR/TAP), member 8
hsa:225 ABCD2; ATP-binding cassette, sub-family D (ALD), member 2
hsa:6890 TAP1; transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
hsa:6891 TAP2; transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)

hsa04540 Gap junction - Homo sapiens (human) (22)



cpd:C00165 Diacylglycerol
cpd:C00533 Nitric oxide
cpd:C00547 L-Noradrenaline
cpd:C00575 3',5'-Cyclic AMP
cpd:C03758 Dopamine
hsa:109 ADCY3; adenylate cyclase 3 (EC:4.6.1.1)
hsa:112 ADCY6; adenylate cyclase 6 (EC:4.6.1.1)
hsa:1812 DRD1; dopamine receptor D1
hsa:1813 DRD2; dopamine receptor D2
hsa:2697 GJA1; gap junction protein, alpha 1, 43kDa
hsa:3708 ITPR1; inositol 1,4,5-trisphosphate receptor, type 1
hsa:5605 MAP2K2; mitogen-activated protein kinase kinase 2 (EC:2.7.12.2)
hsa:5594 MAPK1; mitogen-activated protein kinase 1 (EC:2.7.11.24)
hsa:5595 MAPK3; mitogen-activated protein kinase 3 (EC:2.7.11.24)
hsa:5154 PDGFA; platelet-derived growth factor alpha polypeptide
hsa:5155 PDGFB; platelet-derived growth factor beta polypeptide
hsa:5330 PLCB2; phospholipase C, beta 2 (EC:3.1.4.11)
hsa:5331 PLCB3; phospholipase C, beta 3 (phosphatidylinositol-specific) (EC:3.1.4.11)
hsa:5578 PRKCA; protein kinase C, alpha (EC:2.7.11.13)
hsa:5579 PRKCB; protein kinase C, beta (EC:2.7.11.13)
hsa:7082 TJP1; tight junction protein 1 (zona occludens 1)
hsa:81027 TUBB1; tubulin, beta 1 class VI

hsa04978 Mineral absorption - Homo sapiens (human) (22)



cpd:C00031 D-Glucose
cpd:C00038 Zinc cation
cpd:C00064 L-Glutamine
cpd:C00065 L-Serine
cpd:C00078 L-Tryptophan
cpd:C00124 D-Galactose
cpd:C00238 Potassium cation
cpd:C01673 Calcitriol
hsa:475 ATOX1; ATX1 antioxidant protein 1 homolog (yeast) (EC:6.2.1.2)
hsa:481 ATP1B1; ATPase, Na+/K+ transporting, beta 1 polypeptide
hsa:482 ATP1B2; ATPase, Na+/K+ transporting, beta 2 polypeptide (EC:3.6.3.9)
hsa:483 ATP1B3; ATPase, Na+/K+ transporting, beta 3 polypeptide (EC:3.6.3.9)
hsa:538 ATP7A; ATPase, Cu++ transporting, alpha polypeptide (EC:3.6.3.4)
hsa:3162 HMOX1; heme oxygenase (decycling) 1 (EC:1.14.99.3)
hsa:4490 MT1B; metallothionein 1B
hsa:4495 MT1G; metallothionein 1G
hsa:4502 MT2A; metallothionein 2A
hsa:6556 SLC11A1; solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1
hsa:4891 SLC11A2; solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
hsa:1317 SLC31A1; solute carrier family 31 (copper transporters), member 1
hsa:30061 SLC40A1; solute carrier family 40 (iron-regulated transporter), member 1
hsa:7421 VDR; vitamin D (1,25- dihydroxyvitamin D3) receptor

hsa05320 Autoimmune thyroid disease - Homo sapiens (human) (22)



cpd:C01829 Thyroxine
hsa:940 CD28; CD28 molecule
hsa:958 CD40; CD40 molecule, TNF receptor superfamily member 5
hsa:959 CD40LG; CD40 ligand
hsa:941 CD80; CD80 molecule
hsa:942 CD86; CD86 molecule
hsa:1493 CTLA4; cytotoxic T-lymphocyte-associated protein 4
hsa:355 FAS; Fas (TNF receptor superfamily, member 6)
hsa:3002 GZMB; granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) (EC:3.4.21.79)
hsa:3105 HLA-A; major histocompatibility complex, class I, A
hsa:3107 HLA-C; major histocompatibility complex, class I, C
hsa:3109 HLA-DMB; major histocompatibility complex, class II, DM beta
hsa:3118 HLA-DQA2; major histocompatibility complex, class II, DQ alpha 2
hsa:3134 HLA-F; major histocompatibility complex, class I, F
hsa:3135 HLA-G; major histocompatibility complex, class I, G
hsa:3439 IFNA1; interferon, alpha 1
hsa:3443 IFNA6; interferon, alpha 6
hsa:3586 IL10; interleukin 10
hsa:3558 IL2; interleukin 2
hsa:3565 IL4; interleukin 4
hsa:3567 IL5; interleukin 5 (colony-stimulating factor, eosinophil)
hsa:5551 PRF1; perforin 1 (pore forming protein)

hsa04623 Cytosolic DNA-sensing pathway - Homo sapiens (human) (22)



hsa:834 CASP1; caspase 1, apoptosis-related cysteine peptidase (EC:3.4.22.36)
hsa:6351 CCL4; chemokine (C-C motif) ligand 4
hsa:6352 CCL5; chemokine (C-C motif) ligand 5
hsa:1147 CHUK; conserved helix-loop-helix ubiquitous kinase (EC:2.7.11.10)
hsa:3627 CXCL10; chemokine (C-X-C motif) ligand 10
hsa:3439 IFNA1; interferon, alpha 1
hsa:3443 IFNA6; interferon, alpha 6
hsa:3606 IL18; interleukin 18 (interferon-gamma-inducing factor)
hsa:3553 IL1B; interleukin 1, beta
hsa:90865 IL33; interleukin 33
hsa:3569 IL6; interleukin 6 (interferon, beta 2)
hsa:4790 NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
hsa:4792 NFKBIA; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
hsa:4793 NFKBIB; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
hsa:9533 POLR1C; polymerase (RNA) I polypeptide C, 30kDa
hsa:51082 POLR1D; polymerase (RNA) I polypeptide D, 16kDa
hsa:55718 POLR3E; polymerase (RNA) III (DNA directed) polypeptide E (80kD)
hsa:51728 POLR3K; polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
hsa:5970 RELA; v-rel reticuloendotheliosis viral oncogene homolog A (avian)
hsa:11035 RIPK3; receptor-interacting serine-threonine kinase 3 (EC:2.7.11.1)
hsa:340061 TMEM173; transmembrane protein 173
hsa:81030 ZBP1; Z-DNA binding protein 1

hsa04672 Intestinal immune network for IgA production - Homo sapiens (human) (22)



hsa:10803 CCR9; chemokine (C-C motif) receptor 9
hsa:940 CD28; CD28 molecule
hsa:958 CD40; CD40 molecule, TNF receptor superfamily member 5
hsa:959 CD40LG; CD40 ligand
hsa:941 CD80; CD80 molecule
hsa:942 CD86; CD86 molecule
hsa:6387 CXCL12; chemokine (C-X-C motif) ligand 12
hsa:7852 CXCR4; chemokine (C-X-C motif) receptor 4
hsa:3109 HLA-DMB; major histocompatibility complex, class II, DM beta
hsa:3118 HLA-DQA2; major histocompatibility complex, class II, DQ alpha 2
hsa:29851 ICOS; inducible T-cell co-stimulator
hsa:3586 IL10; interleukin 10
hsa:3600 IL15; interleukin 15
hsa:3601 IL15RA; interleukin 15 receptor, alpha
hsa:3558 IL2; interleukin 2
hsa:3565 IL4; interleukin 4
hsa:3567 IL5; interleukin 5 (colony-stimulating factor, eosinophil)
hsa:3569 IL6; interleukin 6 (interferon, beta 2)
hsa:3676 ITGA4; integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
hsa:3695 ITGB7; integrin, beta 7
hsa:9020 MAP3K14; mitogen-activated protein kinase kinase kinase 14 (EC:2.7.11.25)
hsa:7040 TGFB1; transforming growth factor, beta 1

hsa05020 Prion diseases - Homo sapiens (human) (22)



cpd:C00027 Hydrogen peroxide
cpd:C00575 3',5'-Cyclic AMP
hsa:581 BAX; BCL2-associated X protein
hsa:712 C1QA; complement component 1, q subcomponent, A chain
hsa:714 C1QC; complement component 1, q subcomponent, C chain
hsa:727 C5; complement component 5
hsa:729 C6; complement component 6
hsa:730 C7; complement component 7
hsa:731 C8A; complement component 8, alpha polypeptide
hsa:732 C8B; complement component 8, beta polypeptide
hsa:6352 CCL5; chemokine (C-C motif) ligand 5
hsa:1958 EGR1; early growth response 1
hsa:2534 FYN; FYN oncogene related to SRC, FGR, YES (EC:2.7.10.2)
hsa:3309 HSPA5; heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
hsa:3552 IL1A; interleukin 1, alpha
hsa:3553 IL1B; interleukin 1, beta
hsa:3569 IL6; interleukin 6 (interferon, beta 2)
hsa:5605 MAP2K2; mitogen-activated protein kinase kinase 2 (EC:2.7.12.2)
hsa:5594 MAPK1; mitogen-activated protein kinase 1 (EC:2.7.11.24)
hsa:5595 MAPK3; mitogen-activated protein kinase 3 (EC:2.7.11.24)
hsa:6647 SOD1; superoxide dismutase 1, soluble (EC:1.15.1.1)
hsa:10963 STIP1; stress-induced-phosphoprotein 1

hsa05221 Acute myeloid leukemia - Homo sapiens (human) (21)



hsa:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1)
hsa:572 BAD; BCL2-associated agonist of cell death
hsa:595 CCND1; cyclin D1
hsa:1050 CEBPA; CCAAT/enhancer binding protein (C/EBP), alpha
hsa:1147 CHUK; conserved helix-loop-helix ubiquitous kinase (EC:2.7.11.10)
hsa:3728 JUP; junction plakoglobin
hsa:5605 MAP2K2; mitogen-activated protein kinase kinase 2 (EC:2.7.12.2)
hsa:5594 MAPK1; mitogen-activated protein kinase 1 (EC:2.7.11.24)
hsa:5595 MAPK3; mitogen-activated protein kinase 3 (EC:2.7.11.24)
hsa:2475 MTOR; mechanistic target of rapamycin (serine/threonine kinase) (EC:2.7.11.1)
hsa:4609 MYC; v-myc myelocytomatosis viral oncogene homolog (avian)
hsa:4790 NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
hsa:5290 PIK3CA; phosphoinositide-3-kinase, catalytic, alpha polypeptide (EC:2.7.11.1 2.7.1.153)
hsa:5291 PIK3CB; phosphoinositide-3-kinase, catalytic, beta polypeptide (EC:2.7.1.153)
hsa:5294 PIK3CG; phosphoinositide-3-kinase, catalytic, gamma polypeptide (EC:2.7.11.1 2.7.1.153)
hsa:5292 PIM1; pim-1 oncogene (EC:2.7.11.1)
hsa:5371 PML; promyelocytic leukemia
hsa:5467 PPARD; peroxisome proliferator-activated receptor delta
hsa:5970 RELA; v-rel reticuloendotheliosis viral oncogene homolog A (avian)
hsa:6198 RPS6KB1; ribosomal protein S6 kinase, 70kDa, polypeptide 1 (EC:2.7.11.1)
hsa:6934 TCF7L2; transcription factor 7-like 2 (T-cell specific, HMG-box)

hsa05130 Pathogenic Escherichia coli infection - Homo sapiens (human) (21)



cpd:C00350 Phosphatidylethanolamine
hsa:60 ACTB; actin, beta
hsa:71 ACTG1; actin, gamma 1
hsa:10552 ARPC1A; actin related protein 2/3 complex, subunit 1A, 41kDa
hsa:10095 ARPC1B; actin related protein 2/3 complex, subunit 1B, 41kDa
hsa:10109 ARPC2; actin related protein 2/3 complex, subunit 2, 34kDa
hsa:10094 ARPC3; actin related protein 2/3 complex, subunit 3, 21kDa
hsa:10093 ARPC4; actin related protein 2/3 complex, subunit 4, 20kDa
hsa:10092 ARPC5; actin related protein 2/3 complex, subunit 5, 16kDa
hsa:81873 ARPC5L; actin related protein 2/3 complex, subunit 5-like
hsa:929 CD14; CD14 molecule
hsa:9076 CLDN1; claudin 1
hsa:2017 CTTN; cortactin
hsa:2534 FYN; FYN oncogene related to SRC, FGR, YES (EC:2.7.10.2)
hsa:3688 ITGB1; integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
hsa:23643 LY96; lymphocyte antigen 96
hsa:100506658 OCLN; occludin (EC:2.1.1.67)
hsa:5578 PRKCA; protein kinase C, alpha (EC:2.7.11.13)
hsa:7099 TLR4; toll-like receptor 4
hsa:81027 TUBB1; tubulin, beta 1 class VI
hsa:10971 YWHAQ; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide

hsa00480 Glutathione metabolism - Homo sapiens (human) (21)



cpd:C00051 Glutathione
cpd:C00077 L-Ornithine
cpd:C00134 Putrescine
cpd:C00315 Spermidine
cpd:C00750 Spermine
hsa:2729 GCLC; glutamate-cysteine ligase, catalytic subunit (EC:6.3.2.2)
hsa:2730 GCLM; glutamate-cysteine ligase, modifier subunit (EC:6.3.2.2)
hsa:79017 GGCT; gamma-glutamylcyclotransferase (EC:2.3.2.4)
hsa:2878 GPX3; glutathione peroxidase 3 (plasma) (EC:1.11.1.9)
hsa:2937 GSS; glutathione synthetase (EC:6.3.2.3)
hsa:2939 GSTA2; glutathione S-transferase alpha 2 (EC:2.5.1.18)
hsa:2940 GSTA3; glutathione S-transferase alpha 3 (EC:2.5.1.18)
hsa:2944 GSTM1; glutathione S-transferase mu 1 (EC:2.5.1.18)
hsa:2947 GSTM3; glutathione S-transferase mu 3 (brain) (EC:2.5.1.18)
hsa:2948 GSTM4; glutathione S-transferase mu 4 (EC:2.5.1.18)
hsa:2949 GSTM5; glutathione S-transferase mu 5 (EC:2.5.1.18)
hsa:3417 IDH1; isocitrate dehydrogenase 1 (NADP+), soluble (EC:1.1.1.42)
hsa:3418 IDH2; isocitrate dehydrogenase 2 (NADP+), mitochondrial (EC:1.1.1.42)
hsa:51056 LAP3; leucine aminopeptidase 3 (EC:3.4.11.5 3.4.11.1)
hsa:50484 RRM2B; ribonucleotide reductase M2 B (TP53 inducible) (EC:1.17.4.1)
hsa:6723 SRM; spermidine synthase (EC:2.5.1.16)

hsa04114 Oocyte meiosis - Homo sapiens (human) (21)



cpd:C00575 3',5'-Cyclic AMP
hsa:109 ADCY3; adenylate cyclase 3 (EC:4.6.1.1)
hsa:112 ADCY6; adenylate cyclase 6 (EC:4.6.1.1)
hsa:805 CALM2; calmodulin 2 (phosphorylase kinase, delta) (EC:2.7.11.19)
hsa:808 CALM3; calmodulin 3 (phosphorylase kinase, delta) (EC:2.7.11.19)
hsa:891 CCNB1; cyclin B1
hsa:1017 CDK2; cyclin-dependent kinase 2 (EC:2.7.11.22)
hsa:286151 FBXO43; F-box protein 43
hsa:3479 IGF1; insulin-like growth factor 1 (somatomedin C)
hsa:3630 INS; insulin
hsa:3708 ITPR1; inositol 1,4,5-trisphosphate receptor, type 1
hsa:5594 MAPK1; mitogen-activated protein kinase 1 (EC:2.7.11.24)
hsa:5595 MAPK3; mitogen-activated protein kinase 3 (EC:2.7.11.24)
hsa:5530 PPP3CA; protein phosphatase 3, catalytic subunit, alpha isozyme (EC:3.1.3.16)
hsa:5532 PPP3CB; protein phosphatase 3, catalytic subunit, beta isozyme (EC:3.1.3.16)
hsa:5533 PPP3CC; protein phosphatase 3, catalytic subunit, gamma isozyme (EC:3.1.3.16)
hsa:5534 PPP3R1; protein phosphatase 3, regulatory subunit B, alpha (EC:3.1.3.16)
hsa:5535 PPP3R2; protein phosphatase 3, regulatory subunit B, beta (EC:3.1.3.16)
hsa:7529 YWHAB; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide
hsa:7533 YWHAH; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide
hsa:10971 YWHAQ; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide

hsa05332 Graft-versus-host disease - Homo sapiens (human) (21)



cpd:C00338 Lipopolysaccharide
cpd:C00533 Nitric oxide
hsa:940 CD28; CD28 molecule
hsa:941 CD80; CD80 molecule
hsa:942 CD86; CD86 molecule
hsa:355 FAS; Fas (TNF receptor superfamily, member 6)
hsa:3002 GZMB; granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) (EC:3.4.21.79)
hsa:3105 HLA-A; major histocompatibility complex, class I, A
hsa:3107 HLA-C; major histocompatibility complex, class I, C
hsa:3109 HLA-DMB; major histocompatibility complex, class II, DM beta
hsa:3118 HLA-DQA2; major histocompatibility complex, class II, DQ alpha 2
hsa:3134 HLA-F; major histocompatibility complex, class I, F
hsa:3135 HLA-G; major histocompatibility complex, class I, G
hsa:3458 IFNG; interferon, gamma
hsa:3552 IL1A; interleukin 1, alpha
hsa:3553 IL1B; interleukin 1, beta
hsa:3558 IL2; interleukin 2
hsa:3569 IL6; interleukin 6 (interferon, beta 2)
hsa:3824 KLRD1; killer cell lectin-like receptor subfamily D, member 1
hsa:5551 PRF1; perforin 1 (pore forming protein)
hsa:7124 TNF; tumor necrosis factor

hsa05212 Pancreatic cancer - Homo sapiens (human) (21)



hsa:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1)
hsa:572 BAD; BCL2-associated agonist of cell death
hsa:842 CASP9; caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62)
hsa:595 CCND1; cyclin D1
hsa:1147 CHUK; conserved helix-loop-helix ubiquitous kinase (EC:2.7.11.10)
hsa:2064 ERBB2; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) (EC:2.7.10.1)
hsa:3716 JAK1; Janus kinase 1 (EC:2.7.10.2)
hsa:5594 MAPK1; mitogen-activated protein kinase 1 (EC:2.7.11.24)
hsa:5595 MAPK3; mitogen-activated protein kinase 3 (EC:2.7.11.24)
hsa:5601 MAPK9; mitogen-activated protein kinase 9 (EC:2.7.11.24)
hsa:4790 NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
hsa:5228 PGF; placental growth factor
hsa:5290 PIK3CA; phosphoinositide-3-kinase, catalytic, alpha polypeptide (EC:2.7.11.1 2.7.1.153)
hsa:5291 PIK3CB; phosphoinositide-3-kinase, catalytic, beta polypeptide (EC:2.7.1.153)
hsa:5294 PIK3CG; phosphoinositide-3-kinase, catalytic, gamma polypeptide (EC:2.7.11.1 2.7.1.153)
hsa:5337 PLD1; phospholipase D1, phosphatidylcholine-specific (EC:3.1.4.4)
hsa:5970 RELA; v-rel reticuloendotheliosis viral oncogene homolog A (avian)
hsa:4087 SMAD2; SMAD family member 2
hsa:6772 STAT1; signal transducer and activator of transcription 1, 91kDa
hsa:7040 TGFB1; transforming growth factor, beta 1
hsa:7046 TGFBR1; transforming growth factor, beta receptor 1 (EC:2.7.11.30)

hsa00590 Arachidonic acid metabolism - Homo sapiens (human) (20)



cpd:C00157 Phosphatidylcholine
cpd:C00219 Arachidonate
cpd:C00584 Prostaglandin E2
cpd:C02165 Leukotriene B4
cpd:C02166 Leukotriene C4
cpd:C04742 (15S)-15-Hydroxy-5,8,11-cis-13-trans-eicosatetraenoate
cpd:C05951 Leukotriene D4
cpd:C05961 6-Keto-prostaglandin F1alpha
cpd:C06314 Lipoxin A4
cpd:C14777 12(S)-HETE
hsa:239 ALOX12; arachidonate 12-lipoxygenase (EC:1.13.11.31)
hsa:246 ALOX15; arachidonate 15-lipoxygenase (EC:1.13.11.33)
hsa:240 ALOX5; arachidonate 5-lipoxygenase (EC:1.13.11.34)
hsa:873 CBR1; carbonyl reductase 1 (EC:1.1.1.189 1.1.1.197 1.1.1.184)
hsa:2878 GPX3; glutathione peroxidase 3 (plasma) (EC:1.11.1.9)
hsa:4048 LTA4H; leukotriene A4 hydrolase (EC:3.3.2.6)
hsa:5321 PLA2G4A; phospholipase A2, group IVA (cytosolic, calcium-dependent) (EC:3.1.1.5 3.1.1.4)
hsa:9536 PTGES; prostaglandin E synthase (EC:5.3.99.3)
hsa:5743 PTGS2; prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1)
hsa:6916 TBXAS1; thromboxane A synthase 1 (platelet) (EC:5.3.99.5)

hsa04973 Carbohydrate digestion and absorption - Homo sapiens (human) (20)



cpd:C00031 D-Glucose
cpd:C00124 D-Galactose
cpd:C00165 Diacylglycerol
cpd:C00238 Potassium cation
cpd:C00243 Lactose
hsa:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1)
hsa:279 AMY2A; amylase, alpha 2A (pancreatic) (EC:3.2.1.1)
hsa:481 ATP1B1; ATPase, Na+/K+ transporting, beta 1 polypeptide
hsa:482 ATP1B2; ATPase, Na+/K+ transporting, beta 2 polypeptide (EC:3.6.3.9)
hsa:483 ATP1B3; ATPase, Na+/K+ transporting, beta 3 polypeptide (EC:3.6.3.9)
hsa:2538 G6PC; glucose-6-phosphatase, catalytic subunit (EC:3.1.3.9)
hsa:3098 HK1; hexokinase 1 (EC:2.7.1.1)
hsa:3099 HK2; hexokinase 2 (EC:2.7.1.1)
hsa:3101 HK3; hexokinase 3 (white cell) (EC:2.7.1.1)
hsa:5290 PIK3CA; phosphoinositide-3-kinase, catalytic, alpha polypeptide (EC:2.7.11.1 2.7.1.153)
hsa:5291 PIK3CB; phosphoinositide-3-kinase, catalytic, beta polypeptide (EC:2.7.1.153)
hsa:5294 PIK3CG; phosphoinositide-3-kinase, catalytic, gamma polypeptide (EC:2.7.11.1 2.7.1.153)
hsa:5330 PLCB2; phospholipase C, beta 2 (EC:3.1.4.11)
hsa:5579 PRKCB; protein kinase C, beta (EC:2.7.11.13)
hsa:2542 SLC37A4; solute carrier family 37 (glucose-6-phosphate transporter), member 4

hsa04110 Cell cycle - Homo sapiens (human) (20)



hsa:472 ATM; ataxia telangiectasia mutated (EC:2.7.11.1)
hsa:891 CCNB1; cyclin B1
hsa:595 CCND1; cyclin D1
hsa:1017 CDK2; cyclin-dependent kinase 2 (EC:2.7.11.22)
hsa:1026 CDKN1A; cyclin-dependent kinase inhibitor 1A (p21, Cip1)
hsa:1027 CDKN1B; cyclin-dependent kinase inhibitor 1B (p27, Kip1)
hsa:1647 GADD45A; growth arrest and DNA-damage-inducible, alpha
hsa:4616 GADD45B; growth arrest and DNA-damage-inducible, beta
hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26)
hsa:4609 MYC; v-myc myelocytomatosis viral oncogene homolog (avian)
hsa:5111 PCNA; proliferating cell nuclear antigen
hsa:5933 RBL1; retinoblastoma-like 1 (p107)
hsa:5934 RBL2; retinoblastoma-like 2 (p130)
hsa:2810 SFN; stratifin
hsa:4087 SMAD2; SMAD family member 2
hsa:7029 TFDP2; transcription factor Dp-2 (E2F dimerization partner 2)
hsa:7040 TGFB1; transforming growth factor, beta 1
hsa:7529 YWHAB; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide
hsa:7533 YWHAH; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide
hsa:10971 YWHAQ; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide

hsa00564 Glycerophospholipid metabolism - Homo sapiens (human) (20)



cpd:C00114 Choline
cpd:C00157 Phosphatidylcholine
cpd:C00189 Ethanolamine
cpd:C00350 Phosphatidylethanolamine
cpd:C01194 1-Phosphatidyl-D-myo-inositol
cpd:C02737 Phosphatidylserine
cpd:C05980 Cardiolipin
hsa:84803 AGPAT9; 1-acylglycerol-3-phosphate O-acyltransferase 9 (EC:2.3.1.15)
hsa:8525 DGKZ; diacylglycerol kinase, zeta (EC:2.7.1.107)
hsa:2820 GPD2; glycerol-3-phosphate dehydrogenase 2 (mitochondrial) (EC:1.1.5.3)
hsa:79888 LPCAT1; lysophosphatidylcholine acyltransferase 1 (EC:2.3.1.23 2.3.1.67)
hsa:254531 LPCAT4; lysophosphatidylcholine acyltransferase 4 (EC:2.3.1.51)
hsa:23175 LPIN1; lipin 1 (EC:3.1.3.4)
hsa:9663 LPIN2; lipin 2 (EC:3.1.3.4)
hsa:10434 LYPLA1; lysophospholipase I (EC:3.1.1.5 3.1.2.-)
hsa:9489 PGS1; phosphatidylglycerophosphate synthase 1 (EC:2.7.8.5)
hsa:5321 PLA2G4A; phospholipase A2, group IVA (cytosolic, calcium-dependent) (EC:3.1.1.5 3.1.1.4)
hsa:5337 PLD1; phospholipase D1, phosphatidylcholine-specific (EC:3.1.4.4)
hsa:9791 PTDSS1; phosphatidylserine synthase 1
hsa:6901 TAZ; tafazzin

hsa04974 Protein digestion and absorption - Homo sapiens (human) (20)



cpd:C00062 L-Arginine
cpd:C00064 L-Glutamine
cpd:C00065 L-Serine
cpd:C00078 L-Tryptophan
cpd:C00134 Putrescine
cpd:C00238 Potassium cation
hsa:481 ATP1B1; ATPase, Na+/K+ transporting, beta 1 polypeptide
hsa:482 ATP1B2; ATPase, Na+/K+ transporting, beta 2 polypeptide (EC:3.6.3.9)
hsa:483 ATP1B3; ATPase, Na+/K+ transporting, beta 3 polypeptide (EC:3.6.3.9)
hsa:1303 COL12A1; collagen, type XII, alpha 1
hsa:1277 COL1A1; collagen, type I, alpha 1
hsa:1278 COL1A2; collagen, type I, alpha 2
hsa:1280 COL2A1; collagen, type II, alpha 1
hsa:1287 COL4A5; collagen, type IV, alpha 5
hsa:1291 COL6A1; collagen, type VI, alpha 1
hsa:1293 COL6A3; collagen, type VI, alpha 3
hsa:2006 ELN; elastin
hsa:5644 PRSS1; protease, serine, 1 (trypsin 1) (EC:3.4.21.4)
hsa:117247 SLC16A10; solute carrier family 16, member 10 (aromatic amino acid transporter)
hsa:6520 SLC3A2; solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2

hsa04120 Ubiquitin mediated proteolysis - Homo sapiens (human) (20)



hsa:329 BIRC2; baculoviral IAP repeat containing 2
hsa:330 BIRC3; baculoviral IAP repeat containing 3
hsa:1642 DDB1; damage-specific DNA binding protein 1, 127kDa
hsa:1643 DDB2; damage-specific DNA binding protein 2, 48kDa
hsa:9817 KEAP1; kelch-like ECH-associated protein 1
hsa:90293 KLHL13; kelch-like 13 (Drosophila)
hsa:4734 NEDD4; neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase (EC:6.3.2.-)
hsa:9063 PIAS2; protein inhibitor of activated STAT, 2
hsa:5371 PML; promyelocytic leukemia
hsa:8651 SOCS1; suppressor of cytokine signaling 1
hsa:9021 SOCS3; suppressor of cytokine signaling 3
hsa:7189 TRAF6; TNF receptor-associated factor 6, E3 ubiquitin protein ligase
hsa:22954 TRIM32; tripartite motif containing 32
hsa:7322 UBE2D2; ubiquitin-conjugating enzyme E2D 2 (EC:6.3.2.19)
hsa:7329 UBE2I; ubiquitin-conjugating enzyme E2I (EC:6.3.2.19)
hsa:9246 UBE2L6; ubiquitin-conjugating enzyme E2L 6 (EC:6.3.2.19)
hsa:27338 UBE2S; ubiquitin-conjugating enzyme E2S (EC:6.3.2.19)
hsa:22888 UBOX5; U-box domain containing 5
hsa:51366 UBR5; ubiquitin protein ligase E3 component n-recognin 5
hsa:11059 WWP1; WW domain containing E3 ubiquitin protein ligase 1

hsa05030 Cocaine addiction - Homo sapiens (human) (20)



cpd:C00027 Hydrogen peroxide
cpd:C00355 3,4-Dihydroxy-L-phenylalanine
cpd:C00575 3',5'-Cyclic AMP
cpd:C03758 Dopamine
hsa:1388 ATF6B; activating transcription factor 6 beta
hsa:1385 CREB1; cAMP responsive element binding protein 1
hsa:10488 CREB3; cAMP responsive element binding protein 3
hsa:9586 CREB5; cAMP responsive element binding protein 5
hsa:1644 DDC; dopa decarboxylase (aromatic L-amino acid decarboxylase) (EC:4.1.1.28)
hsa:1742 DLG4; discs, large homolog 4 (Drosophila)
hsa:1812 DRD1; dopamine receptor D1
hsa:1813 DRD2; dopamine receptor D2
hsa:2903 GRIN2A; glutamate receptor, ionotropic, N-methyl D-aspartate 2A
hsa:3725 JUN; jun proto-oncogene
hsa:4128 MAOA; monoamine oxidase A (EC:1.4.3.4)
hsa:4790 NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
hsa:5173 PDYN; prodynorphin
hsa:5970 RELA; v-rel reticuloendotheliosis viral oncogene homolog A (avian)
hsa:6531 SLC6A3; solute carrier family 6 (neurotransmitter transporter, dopamine), member 3
hsa:7054 TH; tyrosine hydroxylase (EC:1.14.16.2)

hsa05220 Chronic myeloid leukemia - Homo sapiens (human) (20)



hsa:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1)
hsa:572 BAD; BCL2-associated agonist of cell death
hsa:595 CCND1; cyclin D1
hsa:1026 CDKN1A; cyclin-dependent kinase inhibitor 1A (p21, Cip1)
hsa:1027 CDKN1B; cyclin-dependent kinase inhibitor 1B (p27, Kip1)
hsa:1147 CHUK; conserved helix-loop-helix ubiquitous kinase (EC:2.7.11.10)
hsa:1488 CTBP2; C-terminal binding protein 2
hsa:5605 MAP2K2; mitogen-activated protein kinase kinase 2 (EC:2.7.12.2)
hsa:5594 MAPK1; mitogen-activated protein kinase 1 (EC:2.7.11.24)
hsa:5595 MAPK3; mitogen-activated protein kinase 3 (EC:2.7.11.24)
hsa:4609 MYC; v-myc myelocytomatosis viral oncogene homolog (avian)
hsa:4790 NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
hsa:4792 NFKBIA; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
hsa:5290 PIK3CA; phosphoinositide-3-kinase, catalytic, alpha polypeptide (EC:2.7.11.1 2.7.1.153)
hsa:5291 PIK3CB; phosphoinositide-3-kinase, catalytic, beta polypeptide (EC:2.7.1.153)
hsa:5294 PIK3CG; phosphoinositide-3-kinase, catalytic, gamma polypeptide (EC:2.7.11.1 2.7.1.153)
hsa:5781 PTPN11; protein tyrosine phosphatase, non-receptor type 11 (EC:3.1.3.48)
hsa:5970 RELA; v-rel reticuloendotheliosis viral oncogene homolog A (avian)
hsa:7040 TGFB1; transforming growth factor, beta 1
hsa:7046 TGFBR1; transforming growth factor, beta receptor 1 (EC:2.7.11.30)

hsa04350 TGF-beta signaling pathway - Homo sapiens (human) (19)



hsa:650 BMP2; bone morphogenetic protein 2
hsa:654 BMP6; bone morphogenetic protein 6
hsa:1634 DCN; decorin
hsa:3397 ID1; inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
hsa:3398 ID2; inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
hsa:3458 IFNG; interferon, gamma
hsa:3624 INHBA; inhibin, beta A
hsa:5594 MAPK1; mitogen-activated protein kinase 1 (EC:2.7.11.24)
hsa:5595 MAPK3; mitogen-activated protein kinase 3 (EC:2.7.11.24)
hsa:4609 MYC; v-myc myelocytomatosis viral oncogene homolog (avian)
hsa:4838 NODAL; nodal homolog (mouse)
hsa:5933 RBL1; retinoblastoma-like 1 (p107)
hsa:5934 RBL2; retinoblastoma-like 2 (p130)
hsa:6198 RPS6KB1; ribosomal protein S6 kinase, 70kDa, polypeptide 1 (EC:2.7.11.1)
hsa:4087 SMAD2; SMAD family member 2
hsa:7040 TGFB1; transforming growth factor, beta 1
hsa:7046 TGFBR1; transforming growth factor, beta receptor 1 (EC:2.7.11.30)
hsa:7057 THBS1; thrombospondin 1
hsa:7124 TNF; tumor necrosis factor

hsa00380 Tryptophan metabolism - Homo sapiens (human) (19)



cpd:C00078 L-Tryptophan
cpd:C00328 L-Kynurenine
cpd:C01598 Melatonin
cpd:C01717 4-Hydroxy-2-quinolinecarboxylic acid
cpd:C02700 L-Formylkynurenine
hsa:38 ACAT1; acetyl-CoA acetyltransferase 1 (EC:2.3.1.9)
hsa:219 ALDH1B1; aldehyde dehydrogenase 1 family, member B1 (EC:1.2.1.3)
hsa:501 ALDH7A1; aldehyde dehydrogenase 7 family, member A1 (EC:1.2.1.3 1.2.1.8 1.2.1.31)
hsa:223 ALDH9A1; aldehyde dehydrogenase 9 family, member A1 (EC:1.2.1.3 1.2.1.19 1.2.1.47)
hsa:847 CAT; catalase (EC:1.11.1.6)
hsa:883 CCBL1; cysteine conjugate-beta lyase, cytoplasmic (EC:2.6.1.64 2.6.1.7 4.4.1.13)
hsa:1545 CYP1B1; cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1)
hsa:1644 DDC; dopa decarboxylase (aromatic L-amino acid decarboxylase) (EC:4.1.1.28)
hsa:1892 ECHS1; enoyl CoA hydratase, short chain, 1, mitochondrial (EC:4.2.1.17)
hsa:3030 HADHA; hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit (EC:4.2.1.17 1.1.1.211)
hsa:3620 IDO1; indoleamine 2,3-dioxygenase 1 (EC:1.13.11.52)
hsa:8942 KYNU; kynureninase (EC:3.7.1.3)
hsa:4128 MAOA; monoamine oxidase A (EC:1.4.3.4)
hsa:6999 TDO2; tryptophan 2,3-dioxygenase (EC:1.13.11.11)

hsa04720 Long-term potentiation - Homo sapiens (human) (19)



cpd:C00165 Diacylglycerol
cpd:C00575 3',5'-Cyclic AMP
hsa:805 CALM2; calmodulin 2 (phosphorylase kinase, delta) (EC:2.7.11.19)
hsa:808 CALM3; calmodulin 3 (phosphorylase kinase, delta) (EC:2.7.11.19)
hsa:2903 GRIN2A; glutamate receptor, ionotropic, N-methyl D-aspartate 2A
hsa:3708 ITPR1; inositol 1,4,5-trisphosphate receptor, type 1
hsa:5605 MAP2K2; mitogen-activated protein kinase kinase 2 (EC:2.7.12.2)
hsa:5594 MAPK1; mitogen-activated protein kinase 1 (EC:2.7.11.24)
hsa:5595 MAPK3; mitogen-activated protein kinase 3 (EC:2.7.11.24)
hsa:5330 PLCB2; phospholipase C, beta 2 (EC:3.1.4.11)
hsa:5331 PLCB3; phospholipase C, beta 3 (phosphatidylinositol-specific) (EC:3.1.4.11)
hsa:5502 PPP1R1A; protein phosphatase 1, regulatory (inhibitor) subunit 1A (EC:3.1.3.16)
hsa:5530 PPP3CA; protein phosphatase 3, catalytic subunit, alpha isozyme (EC:3.1.3.16)
hsa:5532 PPP3CB; protein phosphatase 3, catalytic subunit, beta isozyme (EC:3.1.3.16)
hsa:5533 PPP3CC; protein phosphatase 3, catalytic subunit, gamma isozyme (EC:3.1.3.16)
hsa:5534 PPP3R1; protein phosphatase 3, regulatory subunit B, alpha (EC:3.1.3.16)
hsa:5535 PPP3R2; protein phosphatase 3, regulatory subunit B, beta (EC:3.1.3.16)
hsa:5578 PRKCA; protein kinase C, alpha (EC:2.7.11.13)
hsa:5579 PRKCB; protein kinase C, beta (EC:2.7.11.13)

hsa05214 Glioma - Homo sapiens (human) (19)



cpd:C00165 Diacylglycerol
hsa:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1)
hsa:805 CALM2; calmodulin 2 (phosphorylase kinase, delta) (EC:2.7.11.19)
hsa:808 CALM3; calmodulin 3 (phosphorylase kinase, delta) (EC:2.7.11.19)
hsa:595 CCND1; cyclin D1
hsa:1026 CDKN1A; cyclin-dependent kinase inhibitor 1A (p21, Cip1)
hsa:3479 IGF1; insulin-like growth factor 1 (somatomedin C)
hsa:5605 MAP2K2; mitogen-activated protein kinase kinase 2 (EC:2.7.12.2)
hsa:5594 MAPK1; mitogen-activated protein kinase 1 (EC:2.7.11.24)
hsa:5595 MAPK3; mitogen-activated protein kinase 3 (EC:2.7.11.24)
hsa:2475 MTOR; mechanistic target of rapamycin (serine/threonine kinase) (EC:2.7.11.1)
hsa:5154 PDGFA; platelet-derived growth factor alpha polypeptide
hsa:5155 PDGFB; platelet-derived growth factor beta polypeptide
hsa:5290 PIK3CA; phosphoinositide-3-kinase, catalytic, alpha polypeptide (EC:2.7.11.1 2.7.1.153)
hsa:5291 PIK3CB; phosphoinositide-3-kinase, catalytic, beta polypeptide (EC:2.7.1.153)
hsa:5294 PIK3CG; phosphoinositide-3-kinase, catalytic, gamma polypeptide (EC:2.7.11.1 2.7.1.153)
hsa:5335 PLCG1; phospholipase C, gamma 1 (EC:3.1.4.11)
hsa:5578 PRKCA; protein kinase C, alpha (EC:2.7.11.13)
hsa:5579 PRKCB; protein kinase C, beta (EC:2.7.11.13)

hsa04070 Phosphatidylinositol signaling system - Homo sapiens (human) (19)



cpd:C00165 Diacylglycerol
cpd:C01194 1-Phosphatidyl-D-myo-inositol
hsa:805 CALM2; calmodulin 2 (phosphorylase kinase, delta) (EC:2.7.11.19)
hsa:808 CALM3; calmodulin 3 (phosphorylase kinase, delta) (EC:2.7.11.19)
hsa:8525 DGKZ; diacylglycerol kinase, zeta (EC:2.7.1.107)
hsa:3613 IMPA2; inositol(myo)-1(or 4)-monophosphatase 2 (EC:3.1.3.25)
hsa:3633 INPP5B; inositol polyphosphate-5-phosphatase, 75kDa (EC:3.1.3.36)
hsa:27124 INPP5J; inositol polyphosphate-5-phosphatase J (EC:3.1.3.56)
hsa:3706 ITPKA; inositol-trisphosphate 3-kinase A (EC:2.7.1.127)
hsa:3708 ITPR1; inositol 1,4,5-trisphosphate receptor, type 1
hsa:5289 PIK3C3; phosphoinositide-3-kinase, class 3 (EC:2.7.1.137)
hsa:5290 PIK3CA; phosphoinositide-3-kinase, catalytic, alpha polypeptide (EC:2.7.11.1 2.7.1.153)
hsa:5291 PIK3CB; phosphoinositide-3-kinase, catalytic, beta polypeptide (EC:2.7.1.153)
hsa:5294 PIK3CG; phosphoinositide-3-kinase, catalytic, gamma polypeptide (EC:2.7.11.1 2.7.1.153)
hsa:5330 PLCB2; phospholipase C, beta 2 (EC:3.1.4.11)
hsa:5331 PLCB3; phospholipase C, beta 3 (phosphatidylinositol-specific) (EC:3.1.4.11)
hsa:5335 PLCG1; phospholipase C, gamma 1 (EC:3.1.4.11)
hsa:5578 PRKCA; protein kinase C, alpha (EC:2.7.11.13)
hsa:5579 PRKCB; protein kinase C, beta (EC:2.7.11.13)

hsa00190 Oxidative phosphorylation - Homo sapiens (human) (19)



cpd:C00002 ATP
hsa:479 ATP12A; ATPase, H+/K+ transporting, nongastric, alpha polypeptide (EC:3.6.3.10)
hsa:498 ATP5A1; ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle
hsa:513 ATP5D; ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit (EC:3.6.1.14)
hsa:516 ATP5G1; ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)
hsa:4508 ATP6; ATP synthase F0 subunit 6
hsa:535 ATP6V0A1; ATPase, H+ transporting, lysosomal V0 subunit a1 (EC:3.6.3.14)
hsa:533 ATP6V0B; ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b (EC:3.6.3.14)
hsa:245972 ATP6V0D2; ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2 (EC:3.6.3.14)
hsa:523 ATP6V1A; ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A (EC:3.6.3.14)
hsa:4514 COX3; cytochrome c oxidase III
hsa:1350 COX7C; cytochrome c oxidase subunit VIIc (EC:1.9.3.1)
hsa:4519 CYTB; cytochrome b
hsa:4535 ND1; NADH dehydrogenase, subunit 1 (complex I)
hsa:4538 ND4; NADH dehydrogenase, subunit 4 (complex I)
hsa:4725 NDUFS5; NADH dehydrogenase (ubiquinone) Fe-S protein 5, 15kDa (NADH-coenzyme Q reductase)
hsa:374291 NDUFS7; NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase) (EC:1.6.5.3 1.6.99.3)
hsa:4731 NDUFV3; NADH dehydrogenase (ubiquinone) flavoprotein 3, 10kDa (EC:1.6.5.3)
hsa:5464 PPA1; pyrophosphatase (inorganic) 1 (EC:3.6.1.1)

hsa04930 Type II diabetes mellitus - Homo sapiens (human) (19)



cpd:C00002 ATP
cpd:C00031 D-Glucose
cpd:C00238 Potassium cation
hsa:8913 CACNA1G; calcium channel, voltage-dependent, T type, alpha 1G subunit
hsa:3098 HK1; hexokinase 1 (EC:2.7.1.1)
hsa:3099 HK2; hexokinase 2 (EC:2.7.1.1)
hsa:3101 HK3; hexokinase 3 (white cell) (EC:2.7.1.1)
hsa:3630 INS; insulin
hsa:5594 MAPK1; mitogen-activated protein kinase 1 (EC:2.7.11.24)
hsa:5595 MAPK3; mitogen-activated protein kinase 3 (EC:2.7.11.24)
hsa:5601 MAPK9; mitogen-activated protein kinase 9 (EC:2.7.11.24)
hsa:2475 MTOR; mechanistic target of rapamycin (serine/threonine kinase) (EC:2.7.11.1)
hsa:5290 PIK3CA; phosphoinositide-3-kinase, catalytic, alpha polypeptide (EC:2.7.11.1 2.7.1.153)
hsa:5291 PIK3CB; phosphoinositide-3-kinase, catalytic, beta polypeptide (EC:2.7.1.153)
hsa:5294 PIK3CG; phosphoinositide-3-kinase, catalytic, gamma polypeptide (EC:2.7.11.1 2.7.1.153)
hsa:5315 PKM2; pyruvate kinase, muscle (EC:2.7.1.40)
hsa:8651 SOCS1; suppressor of cytokine signaling 1
hsa:9021 SOCS3; suppressor of cytokine signaling 3
hsa:7124 TNF; tumor necrosis factor

hsa04961 Endocrine and other factor-regulated calcium reabsorption - Homo sapiens (human) (19)



cpd:C00165 Diacylglycerol
cpd:C00238 Potassium cation
cpd:C00575 3',5'-Cyclic AMP
cpd:C00951 Estradiol-17beta
cpd:C01673 Calcitriol
hsa:112 ADCY6; adenylate cyclase 6 (EC:4.6.1.1)
hsa:160 AP2A1; adaptor-related protein complex 2, alpha 1 subunit
hsa:481 ATP1B1; ATPase, Na+/K+ transporting, beta 1 polypeptide
hsa:482 ATP1B2; ATPase, Na+/K+ transporting, beta 2 polypeptide (EC:3.6.3.9)
hsa:483 ATP1B3; ATPase, Na+/K+ transporting, beta 3 polypeptide (EC:3.6.3.9)
hsa:624 BDKRB2; bradykinin receptor B2
hsa:1211 CLTA; clathrin, light chain A
hsa:1759 DNM1; dynamin 1 (EC:3.6.5.5)
hsa:2099 ESR1; estrogen receptor 1
hsa:5330 PLCB2; phospholipase C, beta 2 (EC:3.1.4.11)
hsa:5331 PLCB3; phospholipase C, beta 3 (phosphatidylinositol-specific) (EC:3.1.4.11)
hsa:5578 PRKCA; protein kinase C, alpha (EC:2.7.11.13)
hsa:5579 PRKCB; protein kinase C, beta (EC:2.7.11.13)
hsa:7421 VDR; vitamin D (1,25- dihydroxyvitamin D3) receptor

hsa05110 Vibrio cholerae infection - Homo sapiens (human) (18)



cpd:C00165 Diacylglycerol
cpd:C00238 Potassium cation
cpd:C00575 3',5'-Cyclic AMP
hsa:60 ACTB; actin, beta
hsa:71 ACTG1; actin, gamma 1
hsa:109 ADCY3; adenylate cyclase 3 (EC:4.6.1.1)
hsa:535 ATP6V0A1; ATPase, H+ transporting, lysosomal V0 subunit a1 (EC:3.6.3.14)
hsa:533 ATP6V0B; ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b (EC:3.6.3.14)
hsa:245972 ATP6V0D2; ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2 (EC:3.6.3.14)
hsa:523 ATP6V1A; ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A (EC:3.6.3.14)
hsa:10945 KDELR1; KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1
hsa:11015 KDELR3; KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
hsa:5335 PLCG1; phospholipase C, gamma 1 (EC:3.1.4.11)
hsa:5578 PRKCA; protein kinase C, alpha (EC:2.7.11.13)
hsa:5579 PRKCB; protein kinase C, beta (EC:2.7.11.13)
hsa:6558 SLC12A2; solute carrier family 12 (sodium/potassium/chloride transporters), member 2
hsa:7082 TJP1; tight junction protein 1 (zona occludens 1)
hsa:9414 TJP2; tight junction protein 2 (zona occludens 2)

hsa05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) - Homo sapiens (human) (18)



hsa:60 ACTB; actin, beta
hsa:71 ACTG1; actin, gamma 1
hsa:87 ACTN1; actinin, alpha 1
hsa:1674 DES; desmin
hsa:2697 GJA1; gap junction protein, alpha 1, 43kDa
hsa:3673 ITGA2; integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
hsa:3676 ITGA4; integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
hsa:3678 ITGA5; integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
hsa:3655 ITGA6; integrin, alpha 6
hsa:8516 ITGA8; integrin, alpha 8
hsa:3680 ITGA9; integrin, alpha 9
hsa:3688 ITGB1; integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
hsa:3690 ITGB3; integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
hsa:3693 ITGB5; integrin, beta 5
hsa:3695 ITGB7; integrin, beta 7
hsa:3728 JUP; junction plakoglobin
hsa:4000 LMNA; lamin A/C
hsa:6934 TCF7L2; transcription factor 7-like 2 (T-cell specific, HMG-box)

hsa00520 Amino sugar and nucleotide sugar metabolism - Homo sapiens (human) (18)



cpd:C00031 D-Glucose
cpd:C00124 D-Galactose
cpd:C00159 D-Mannose
cpd:C00270 N-Acetylneuraminate
cpd:C00329 D-Glucosamine
hsa:1118 CHIT1; chitinase 1 (chitotriosidase) (EC:3.2.1.14)
hsa:1727 CYB5R3; cytochrome b5 reductase 3 (EC:1.6.2.2)
hsa:8790 FPGT; fucose-1-phosphate guanylyltransferase (EC:2.7.7.30)
hsa:2592 GALT; galactose-1-phosphate uridylyltransferase (EC:2.7.7.12)
hsa:2673 GFPT1; glutamine--fructose-6-phosphate transaminase 1 (EC:2.6.1.16)
hsa:10020 GNE; glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase (EC:5.1.3.14 2.7.1.60)
hsa:2821 GPI; glucose-6-phosphate isomerase (EC:5.3.1.9)
hsa:3074 HEXB; hexosaminidase B (beta polypeptide) (EC:3.2.1.52)
hsa:3098 HK1; hexokinase 1 (EC:2.7.1.1)
hsa:3099 HK2; hexokinase 2 (EC:2.7.1.1)
hsa:3101 HK3; hexokinase 3 (white cell) (EC:2.7.1.1)
hsa:80896 NPL; N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase) (EC:4.1.3.3)
hsa:55276 PGM2; phosphoglucomutase 2 (EC:5.4.2.2 5.4.2.7)

hsa04530 Tight junction - Homo sapiens (human) (18)



hsa:60 ACTB; actin, beta
hsa:71 ACTG1; actin, gamma 1
hsa:87 ACTN1; actinin, alpha 1
hsa:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1)
hsa:9076 CLDN1; claudin 1
hsa:1365 CLDN3; claudin 3
hsa:2017 CTTN; cortactin
hsa:4628 MYH10; myosin, heavy chain 10, non-muscle
hsa:4624 MYH6; myosin, heavy chain 6, cardiac muscle, alpha
hsa:4627 MYH9; myosin, heavy chain 9, non-muscle
hsa:100506658 OCLN; occludin (EC:2.1.1.67)
hsa:84552 PARD6G; par-6 partitioning defective 6 homolog gamma (C. elegans)
hsa:5578 PRKCA; protein kinase C, alpha (EC:2.7.11.13)
hsa:5579 PRKCB; protein kinase C, beta (EC:2.7.11.13)
hsa:6237 RRAS; related RAS viral (r-ras) oncogene homolog
hsa:7082 TJP1; tight junction protein 1 (zona occludens 1)
hsa:9414 TJP2; tight junction protein 2 (zona occludens 2)
hsa:7525 YES1; v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1 (EC:2.7.10.2)

hsa05032 Morphine addiction - Homo sapiens (human) (18)



cpd:C00212 Adenosine
cpd:C00238 Potassium cation
cpd:C00575 3',5'-Cyclic AMP
cpd:C03758 Dopamine
hsa:109 ADCY3; adenylate cyclase 3 (EC:4.6.1.1)
hsa:112 ADCY6; adenylate cyclase 6 (EC:4.6.1.1)
hsa:134 ADORA1; adenosine A1 receptor
hsa:1812 DRD1; dopamine receptor D1
hsa:2562 GABRB3; gamma-aminobutyric acid (GABA) A receptor, beta 3
hsa:59345 GNB4; guanine nucleotide binding protein (G protein), beta polypeptide 4
hsa:55970 GNG12; guanine nucleotide binding protein (G protein), gamma 12
hsa:2793 GNGT2; guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2
hsa:2869 GRK5; G protein-coupled receptor kinase 5 (EC:2.7.11.16)
hsa:5137 PDE1C; phosphodiesterase 1C, calmodulin-dependent 70kDa (EC:3.1.4.17)
hsa:5138 PDE2A; phosphodiesterase 2A, cGMP-stimulated (EC:3.1.4.17)
hsa:5142 PDE4B; phosphodiesterase 4B, cAMP-specific (EC:3.1.4.17)
hsa:5578 PRKCA; protein kinase C, alpha (EC:2.7.11.13)
hsa:5579 PRKCB; protein kinase C, beta (EC:2.7.11.13)

hsa04740 Olfactory transduction - Homo sapiens (human) (17)



cpd:C00575 3',5'-Cyclic AMP
hsa:109 ADCY3; adenylate cyclase 3 (EC:4.6.1.1)
hsa:805 CALM2; calmodulin 2 (phosphorylase kinase, delta) (EC:2.7.11.19)
hsa:808 CALM3; calmodulin 3 (phosphorylase kinase, delta) (EC:2.7.11.19)
hsa:390265 OR10G7; olfactory receptor, family 10, subfamily G, member 7
hsa:125963 OR1M1; olfactory receptor, family 1, subfamily M, member 1
hsa:4993 OR2C1; olfactory receptor, family 2, subfamily C, member 1
hsa:219428 OR4C16; olfactory receptor, family 4, subfamily C, member 16
hsa:219875 OR4D5; olfactory receptor, family 4, subfamily D, member 5
hsa:143496 OR52B4; olfactory receptor, family 52, subfamily B, member 4
hsa:390142 OR5D13; olfactory receptor, family 5, subfamily D, member 13
hsa:26341 OR5H1; olfactory receptor, family 5, subfamily H, member 1
hsa:282775 OR5J2; olfactory receptor, family 5, subfamily J, member 2
hsa:219484 OR5M8; olfactory receptor, family 5, subfamily M, member 8
hsa:125958 OR7D4; olfactory receptor, family 7, subfamily D, member 4
hsa:219469 OR8H1; olfactory receptor, family 8, subfamily H, member 1
hsa:5137 PDE1C; phosphodiesterase 1C, calmodulin-dependent 70kDa (EC:3.1.4.17)

hsa05211 Renal cell carcinoma - Homo sapiens (human) (17)



hsa:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1)
hsa:2034 EPAS1; endothelial PAS domain protein 1
hsa:2113 ETS1; v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)
hsa:201163 FLCN; folliculin
hsa:2549 GAB1; GRB2-associated binding protein 1
hsa:3091 HIF1A; hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
hsa:3725 JUN; jun proto-oncogene
hsa:5605 MAP2K2; mitogen-activated protein kinase kinase 2 (EC:2.7.12.2)
hsa:5594 MAPK1; mitogen-activated protein kinase 1 (EC:2.7.11.24)
hsa:5595 MAPK3; mitogen-activated protein kinase 3 (EC:2.7.11.24)
hsa:5155 PDGFB; platelet-derived growth factor beta polypeptide
hsa:5228 PGF; placental growth factor
hsa:5290 PIK3CA; phosphoinositide-3-kinase, catalytic, alpha polypeptide (EC:2.7.11.1 2.7.1.153)
hsa:5291 PIK3CB; phosphoinositide-3-kinase, catalytic, beta polypeptide (EC:2.7.1.153)
hsa:5294 PIK3CG; phosphoinositide-3-kinase, catalytic, gamma polypeptide (EC:2.7.11.1 2.7.1.153)
hsa:5781 PTPN11; protein tyrosine phosphatase, non-receptor type 11 (EC:3.1.3.48)
hsa:7040 TGFB1; transforming growth factor, beta 1

hsa04971 Gastric acid secretion - Homo sapiens (human) (17)



cpd:C00165 Diacylglycerol
cpd:C00238 Potassium cation
cpd:C00575 3',5'-Cyclic AMP
hsa:60 ACTB; actin, beta
hsa:109 ADCY3; adenylate cyclase 3 (EC:4.6.1.1)
hsa:112 ADCY6; adenylate cyclase 6 (EC:4.6.1.1)
hsa:481 ATP1B1; ATPase, Na+/K+ transporting, beta 1 polypeptide
hsa:482 ATP1B2; ATPase, Na+/K+ transporting, beta 2 polypeptide (EC:3.6.3.9)
hsa:483 ATP1B3; ATPase, Na+/K+ transporting, beta 3 polypeptide (EC:3.6.3.9)
hsa:805 CALM2; calmodulin 2 (phosphorylase kinase, delta) (EC:2.7.11.19)
hsa:808 CALM3; calmodulin 3 (phosphorylase kinase, delta) (EC:2.7.11.19)
hsa:3708 ITPR1; inositol 1,4,5-trisphosphate receptor, type 1
hsa:5330 PLCB2; phospholipase C, beta 2 (EC:3.1.4.11)
hsa:5331 PLCB3; phospholipase C, beta 3 (phosphatidylinositol-specific) (EC:3.1.4.11)
hsa:5578 PRKCA; protein kinase C, alpha (EC:2.7.11.13)
hsa:5579 PRKCB; protein kinase C, beta (EC:2.7.11.13)
hsa:115111 SLC26A7; solute carrier family 26, member 7

hsa03013 RNA transport - Homo sapiens (human) (16)



hsa:1917 EEF1A2; eukaryotic translation elongation factor 1 alpha 2
hsa:8890 EIF2B4; eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa
hsa:1974 EIF4A2; eukaryotic translation initiation factor 4A2 (EC:3.6.4.13)
hsa:1975 EIF4B; eukaryotic translation initiation factor 4B
hsa:1982 EIF4G2; eukaryotic translation initiation factor 4 gamma, 2
hsa:1983 EIF5; eukaryotic translation initiation factor 5
hsa:54960 GEMIN8; gem (nuclear organelle) associated protein 8
hsa:55110 MAGOHB; mago-nashi homolog B (Drosophila)
hsa:10762 NUP50; nucleoporin 50kDa
hsa:8761 PABPC4; poly(A) binding protein, cytoplasmic 4 (inducible form)
hsa:10248 POP7; processing of precursor 7, ribonuclease P/MRP subunit (S. cerevisiae) (EC:3.1.26.5)
hsa:10460 TACC3; transforming, acidic coiled-coil containing protein 3
hsa:96764 TGS1; trimethylguanosine synthase 1 (EC:2.1.1.-)
hsa:79228 THOC6; THO complex 6 homolog (Drosophila)
hsa:7329 UBE2I; ubiquitin-conjugating enzyme E2I (EC:6.3.2.19)
hsa:57510 XPO5; exportin 5

hsa04520 Adherens junction - Homo sapiens (human) (16)



hsa:60 ACTB; actin, beta
hsa:71 ACTG1; actin, gamma 1
hsa:87 ACTN1; actinin, alpha 1
hsa:2064 ERBB2; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) (EC:2.7.10.1)
hsa:2534 FYN; FYN oncogene related to SRC, FGR, YES (EC:2.7.10.2)
hsa:6885 MAP3K7; mitogen-activated protein kinase kinase kinase 7 (EC:2.7.11.25)
hsa:5594 MAPK1; mitogen-activated protein kinase 1 (EC:2.7.11.24)
hsa:5595 MAPK3; mitogen-activated protein kinase 3 (EC:2.7.11.24)
hsa:5770 PTPN1; protein tyrosine phosphatase, non-receptor type 1 (EC:3.1.3.48)
hsa:5819 PVRL2; poliovirus receptor-related 2 (herpesvirus entry mediator B)
hsa:4087 SMAD2; SMAD family member 2
hsa:6934 TCF7L2; transcription factor 7-like 2 (T-cell specific, HMG-box)
hsa:7046 TGFBR1; transforming growth factor, beta receptor 1 (EC:2.7.11.30)
hsa:7082 TJP1; tight junction protein 1 (zona occludens 1)
hsa:7414 VCL; vinculin
hsa:7525 YES1; v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1 (EC:2.7.10.2)

hsa05213 Endometrial cancer - Homo sapiens (human) (16)



hsa:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1)
hsa:8313 AXIN2; axin 2
hsa:572 BAD; BCL2-associated agonist of cell death
hsa:842 CASP9; caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62)
hsa:595 CCND1; cyclin D1
hsa:2064 ERBB2; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) (EC:2.7.10.1)
hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26)
hsa:3611 ILK; integrin-linked kinase (EC:2.7.11.1)
hsa:5605 MAP2K2; mitogen-activated protein kinase kinase 2 (EC:2.7.12.2)
hsa:5594 MAPK1; mitogen-activated protein kinase 1 (EC:2.7.11.24)
hsa:5595 MAPK3; mitogen-activated protein kinase 3 (EC:2.7.11.24)
hsa:4609 MYC; v-myc myelocytomatosis viral oncogene homolog (avian)
hsa:5290 PIK3CA; phosphoinositide-3-kinase, catalytic, alpha polypeptide (EC:2.7.11.1 2.7.1.153)
hsa:5291 PIK3CB; phosphoinositide-3-kinase, catalytic, beta polypeptide (EC:2.7.1.153)
hsa:5294 PIK3CG; phosphoinositide-3-kinase, catalytic, gamma polypeptide (EC:2.7.11.1 2.7.1.153)
hsa:6934 TCF7L2; transcription factor 7-like 2 (T-cell specific, HMG-box)

hsa04960 Aldosterone-regulated sodium reabsorption - Homo sapiens (human) (16)



cpd:C00238 Potassium cation
cpd:C00575 3',5'-Cyclic AMP
hsa:481 ATP1B1; ATPase, Na+/K+ transporting, beta 1 polypeptide
hsa:482 ATP1B2; ATPase, Na+/K+ transporting, beta 2 polypeptide (EC:3.6.3.9)
hsa:483 ATP1B3; ATPase, Na+/K+ transporting, beta 3 polypeptide (EC:3.6.3.9)
hsa:3479 IGF1; insulin-like growth factor 1 (somatomedin C)
hsa:3630 INS; insulin
hsa:5594 MAPK1; mitogen-activated protein kinase 1 (EC:2.7.11.24)
hsa:5595 MAPK3; mitogen-activated protein kinase 3 (EC:2.7.11.24)
hsa:5290 PIK3CA; phosphoinositide-3-kinase, catalytic, alpha polypeptide (EC:2.7.11.1 2.7.1.153)
hsa:5291 PIK3CB; phosphoinositide-3-kinase, catalytic, beta polypeptide (EC:2.7.1.153)
hsa:5294 PIK3CG; phosphoinositide-3-kinase, catalytic, gamma polypeptide (EC:2.7.11.1 2.7.1.153)
hsa:5578 PRKCA; protein kinase C, alpha (EC:2.7.11.13)
hsa:5579 PRKCB; protein kinase C, beta (EC:2.7.11.13)
hsa:2810 SFN; stratifin
hsa:9351 SLC9A3R2; solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2

hsa04727 GABAergic synapse - Homo sapiens (human) (16)



cpd:C00064 L-Glutamine
cpd:C00238 Potassium cation
cpd:C00575 3',5'-Cyclic AMP
hsa:109 ADCY3; adenylate cyclase 3 (EC:4.6.1.1)
hsa:112 ADCY6; adenylate cyclase 6 (EC:4.6.1.1)
hsa:23710 GABARAPL1; GABA(A) receptor-associated protein like 1
hsa:2562 GABRB3; gamma-aminobutyric acid (GABA) A receptor, beta 3
hsa:2744 GLS; glutaminase (EC:3.5.1.2)
hsa:27165 GLS2; glutaminase 2 (liver, mitochondrial) (EC:3.5.1.2)
hsa:2752 GLUL; glutamate-ammonia ligase (EC:4.1.1.15 6.3.1.2)
hsa:59345 GNB4; guanine nucleotide binding protein (G protein), beta polypeptide 4
hsa:55970 GNG12; guanine nucleotide binding protein (G protein), gamma 12
hsa:2793 GNGT2; guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2
hsa:5334 PLCL1; phospholipase C-like 1
hsa:5578 PRKCA; protein kinase C, alpha (EC:2.7.11.13)
hsa:5579 PRKCB; protein kinase C, beta (EC:2.7.11.13)

hsa04914 Progesterone-mediated oocyte maturation - Homo sapiens (human) (16)



cpd:C00575 3',5'-Cyclic AMP
hsa:109 ADCY3; adenylate cyclase 3 (EC:4.6.1.1)
hsa:112 ADCY6; adenylate cyclase 6 (EC:4.6.1.1)
hsa:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1)
hsa:891 CCNB1; cyclin B1
hsa:1017 CDK2; cyclin-dependent kinase 2 (EC:2.7.11.22)
hsa:3326 HSP90AB1; heat shock protein 90kDa alpha (cytosolic), class B member 1
hsa:3479 IGF1; insulin-like growth factor 1 (somatomedin C)
hsa:3630 INS; insulin
hsa:5594 MAPK1; mitogen-activated protein kinase 1 (EC:2.7.11.24)
hsa:1432 MAPK14; mitogen-activated protein kinase 14 (EC:2.7.11.24)
hsa:5595 MAPK3; mitogen-activated protein kinase 3 (EC:2.7.11.24)
hsa:5601 MAPK9; mitogen-activated protein kinase 9 (EC:2.7.11.24)
hsa:5290 PIK3CA; phosphoinositide-3-kinase, catalytic, alpha polypeptide (EC:2.7.11.1 2.7.1.153)
hsa:5291 PIK3CB; phosphoinositide-3-kinase, catalytic, beta polypeptide (EC:2.7.1.153)
hsa:5294 PIK3CG; phosphoinositide-3-kinase, catalytic, gamma polypeptide (EC:2.7.11.1 2.7.1.153)

hsa04150 mTOR signaling pathway - Homo sapiens (human) (15)



hsa:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1)
hsa:1975 EIF4B; eukaryotic translation initiation factor 4B
hsa:3091 HIF1A; hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
hsa:3479 IGF1; insulin-like growth factor 1 (somatomedin C)
hsa:3630 INS; insulin
hsa:5594 MAPK1; mitogen-activated protein kinase 1 (EC:2.7.11.24)
hsa:5595 MAPK3; mitogen-activated protein kinase 3 (EC:2.7.11.24)
hsa:2475 MTOR; mechanistic target of rapamycin (serine/threonine kinase) (EC:2.7.11.1)
hsa:5228 PGF; placental growth factor
hsa:5290 PIK3CA; phosphoinositide-3-kinase, catalytic, alpha polypeptide (EC:2.7.11.1 2.7.1.153)
hsa:5291 PIK3CB; phosphoinositide-3-kinase, catalytic, beta polypeptide (EC:2.7.1.153)
hsa:5294 PIK3CG; phosphoinositide-3-kinase, catalytic, gamma polypeptide (EC:2.7.11.1 2.7.1.153)
hsa:6194 RPS6; ribosomal protein S6
hsa:6198 RPS6KB1; ribosomal protein S6 kinase, 70kDa, polypeptide 1 (EC:2.7.11.1)
hsa:92335 STRADA; STE20-related kinase adaptor alpha

hsa05223 Non-small cell lung cancer - Homo sapiens (human) (15)



cpd:C00165 Diacylglycerol
hsa:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1)
hsa:572 BAD; BCL2-associated agonist of cell death
hsa:842 CASP9; caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62)
hsa:595 CCND1; cyclin D1
hsa:2064 ERBB2; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) (EC:2.7.10.1)
hsa:5605 MAP2K2; mitogen-activated protein kinase kinase 2 (EC:2.7.12.2)
hsa:5594 MAPK1; mitogen-activated protein kinase 1 (EC:2.7.11.24)
hsa:5595 MAPK3; mitogen-activated protein kinase 3 (EC:2.7.11.24)
hsa:5290 PIK3CA; phosphoinositide-3-kinase, catalytic, alpha polypeptide (EC:2.7.11.1 2.7.1.153)
hsa:5291 PIK3CB; phosphoinositide-3-kinase, catalytic, beta polypeptide (EC:2.7.1.153)
hsa:5294 PIK3CG; phosphoinositide-3-kinase, catalytic, gamma polypeptide (EC:2.7.11.1 2.7.1.153)
hsa:5335 PLCG1; phospholipase C, gamma 1 (EC:3.1.4.11)
hsa:5578 PRKCA; protein kinase C, alpha (EC:2.7.11.13)
hsa:5579 PRKCB; protein kinase C, beta (EC:2.7.11.13)

hsa05218 Melanoma - Homo sapiens (human) (15)



hsa:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1)
hsa:572 BAD; BCL2-associated agonist of cell death
hsa:595 CCND1; cyclin D1
hsa:1026 CDKN1A; cyclin-dependent kinase inhibitor 1A (p21, Cip1)
hsa:2258 FGF13; fibroblast growth factor 13
hsa:2252 FGF7; fibroblast growth factor 7
hsa:3479 IGF1; insulin-like growth factor 1 (somatomedin C)
hsa:5605 MAP2K2; mitogen-activated protein kinase kinase 2 (EC:2.7.12.2)
hsa:5594 MAPK1; mitogen-activated protein kinase 1 (EC:2.7.11.24)
hsa:5595 MAPK3; mitogen-activated protein kinase 3 (EC:2.7.11.24)
hsa:5154 PDGFA; platelet-derived growth factor alpha polypeptide
hsa:5155 PDGFB; platelet-derived growth factor beta polypeptide
hsa:5290 PIK3CA; phosphoinositide-3-kinase, catalytic, alpha polypeptide (EC:2.7.11.1 2.7.1.153)
hsa:5291 PIK3CB; phosphoinositide-3-kinase, catalytic, beta polypeptide (EC:2.7.1.153)
hsa:5294 PIK3CG; phosphoinositide-3-kinase, catalytic, gamma polypeptide (EC:2.7.11.1 2.7.1.153)

hsa04146 Peroxisome - Homo sapiens (human) (15)



hsa:225 ABCD2; ATP-binding cassette, sub-family D (ALD), member 2
hsa:51 ACOX1; acyl-CoA oxidase 1, palmitoyl (EC:1.3.3.6)
hsa:2180 ACSL1; acyl-CoA synthetase long-chain family member 1 (EC:6.2.1.3)
hsa:847 CAT; catalase (EC:1.11.1.6)
hsa:10455 ECI2; enoyl-CoA delta isomerase 2 (EC:5.3.3.8)
hsa:3417 IDH1; isocitrate dehydrogenase 1 (NADP+), soluble (EC:1.1.1.42)
hsa:3418 IDH2; isocitrate dehydrogenase 2 (NADP+), mitochondrial (EC:1.1.1.42)
hsa:4843 NOS2; nitric oxide synthase 2, inducible (EC:1.14.13.39)
hsa:5052 PRDX1; peroxiredoxin 1 (EC:1.11.1.15)
hsa:25824 PRDX5; peroxiredoxin 5 (EC:1.11.1.15)
hsa:11264 PXMP4; peroxisomal membrane protein 4, 24kDa
hsa:11001 SLC27A2; solute carrier family 27 (fatty acid transporter), member 2 (EC:6.2.1.3)
hsa:6647 SOD1; superoxide dismutase 1, soluble (EC:1.15.1.1)
hsa:6648 SOD2; superoxide dismutase 2, mitochondrial (EC:1.15.1.1)
hsa:7498 XDH; xanthine dehydrogenase (EC:1.17.1.4 1.17.3.2)

hsa04730 Long-term depression - Homo sapiens (human) (15)



cpd:C00165 Diacylglycerol
cpd:C00219 Arachidonate
cpd:C00533 Nitric oxide
hsa:2768 GNA12; guanine nucleotide binding protein (G protein) alpha 12
hsa:3479 IGF1; insulin-like growth factor 1 (somatomedin C)
hsa:3708 ITPR1; inositol 1,4,5-trisphosphate receptor, type 1
hsa:5605 MAP2K2; mitogen-activated protein kinase kinase 2 (EC:2.7.12.2)
hsa:5594 MAPK1; mitogen-activated protein kinase 1 (EC:2.7.11.24)
hsa:5595 MAPK3; mitogen-activated protein kinase 3 (EC:2.7.11.24)
hsa:4842 NOS1; nitric oxide synthase 1 (neuronal) (EC:1.14.13.39)
hsa:5321 PLA2G4A; phospholipase A2, group IVA (cytosolic, calcium-dependent) (EC:3.1.1.5 3.1.1.4)
hsa:5330 PLCB2; phospholipase C, beta 2 (EC:3.1.4.11)
hsa:5331 PLCB3; phospholipase C, beta 3 (phosphatidylinositol-specific) (EC:3.1.4.11)
hsa:5578 PRKCA; protein kinase C, alpha (EC:2.7.11.13)
hsa:5579 PRKCB; protein kinase C, beta (EC:2.7.11.13)

hsa00562 Inositol phosphate metabolism - Homo sapiens (human) (14)



cpd:C01194 1-Phosphatidyl-D-myo-inositol
hsa:4329 ALDH6A1; aldehyde dehydrogenase 6 family, member A1 (EC:1.2.1.27 1.2.1.18)
hsa:3613 IMPA2; inositol(myo)-1(or 4)-monophosphatase 2 (EC:3.1.3.25)
hsa:3633 INPP5B; inositol polyphosphate-5-phosphatase, 75kDa (EC:3.1.3.36)
hsa:27124 INPP5J; inositol polyphosphate-5-phosphatase J (EC:3.1.3.56)
hsa:3706 ITPKA; inositol-trisphosphate 3-kinase A (EC:2.7.1.127)
hsa:5289 PIK3C3; phosphoinositide-3-kinase, class 3 (EC:2.7.1.137)
hsa:5290 PIK3CA; phosphoinositide-3-kinase, catalytic, alpha polypeptide (EC:2.7.11.1 2.7.1.153)
hsa:5291 PIK3CB; phosphoinositide-3-kinase, catalytic, beta polypeptide (EC:2.7.1.153)
hsa:5294 PIK3CG; phosphoinositide-3-kinase, catalytic, gamma polypeptide (EC:2.7.11.1 2.7.1.153)
hsa:5330 PLCB2; phospholipase C, beta 2 (EC:3.1.4.11)
hsa:5331 PLCB3; phospholipase C, beta 3 (phosphatidylinositol-specific) (EC:3.1.4.11)
hsa:5335 PLCG1; phospholipase C, gamma 1 (EC:3.1.4.11)
hsa:7167 TPI1; triosephosphate isomerase 1 (EC:5.3.1.1)

hsa03010 Ribosome - Homo sapiens (human) (14)



hsa:6134 RPL10; ribosomal protein L10
hsa:4736 RPL10A; ribosomal protein L10a (EC:3.6.5.3)
hsa:6141 RPL18; ribosomal protein L18
hsa:6147 RPL23A; ribosomal protein L23a
hsa:6205 RPS11; ribosomal protein S11
hsa:6206 RPS12; ribosomal protein S12
hsa:6209 RPS15; ribosomal protein S15
hsa:6222 RPS18; ribosomal protein S18
hsa:6235 RPS29; ribosomal protein S29
hsa:6188 RPS3; ribosomal protein S3
hsa:6194 RPS6; ribosomal protein S6
hsa:6203 RPS9; ribosomal protein S9
hsa:3921 RPSA; ribosomal protein SA
hsa:7311 UBA52; ubiquitin A-52 residue ribosomal protein fusion product 1

hsa05219 Bladder cancer - Homo sapiens (human) (14)



hsa:595 CCND1; cyclin D1
hsa:1026 CDKN1A; cyclin-dependent kinase inhibitor 1A (p21, Cip1)
hsa:2064 ERBB2; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) (EC:2.7.10.1)
hsa:3576 IL8; interleukin 8
hsa:5605 MAP2K2; mitogen-activated protein kinase kinase 2 (EC:2.7.12.2)
hsa:5594 MAPK1; mitogen-activated protein kinase 1 (EC:2.7.11.24)
hsa:5595 MAPK3; mitogen-activated protein kinase 3 (EC:2.7.11.24)
hsa:4312 MMP1; matrix metallopeptidase 1 (interstitial collagenase) (EC:3.4.24.7)
hsa:4313 MMP2; matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24)
hsa:4318 MMP9; matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35)
hsa:4609 MYC; v-myc myelocytomatosis viral oncogene homolog (avian)
hsa:5228 PGF; placental growth factor
hsa:7057 THBS1; thrombospondin 1
hsa:1890 TYMP; thymidine phosphorylase (EC:2.4.2.4)

hsa00071 Fatty acid metabolism - Homo sapiens (human) (14)



cpd:C00249 Hexadecanoic acid
hsa:33 ACADL; acyl-CoA dehydrogenase, long chain (EC:1.3.99.13)
hsa:37 ACADVL; acyl-CoA dehydrogenase, very long chain (EC:1.3.99.-)
hsa:38 ACAT1; acetyl-CoA acetyltransferase 1 (EC:2.3.1.9)
hsa:51 ACOX1; acyl-CoA oxidase 1, palmitoyl (EC:1.3.3.6)
hsa:2180 ACSL1; acyl-CoA synthetase long-chain family member 1 (EC:6.2.1.3)
hsa:219 ALDH1B1; aldehyde dehydrogenase 1 family, member B1 (EC:1.2.1.3)
hsa:501 ALDH7A1; aldehyde dehydrogenase 7 family, member A1 (EC:1.2.1.3 1.2.1.8 1.2.1.31)
hsa:223 ALDH9A1; aldehyde dehydrogenase 9 family, member A1 (EC:1.2.1.3 1.2.1.19 1.2.1.47)
hsa:1374 CPT1A; carnitine palmitoyltransferase 1A (liver) (EC:2.3.1.21)
hsa:126129 CPT1C; carnitine palmitoyltransferase 1C (EC:2.3.1.21)
hsa:1892 ECHS1; enoyl CoA hydratase, short chain, 1, mitochondrial (EC:4.2.1.17)
hsa:10455 ECI2; enoyl-CoA delta isomerase 2 (EC:5.3.3.8)
hsa:3030 HADHA; hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit (EC:4.2.1.17 1.1.1.211)

hsa05310 Asthma - Homo sapiens (human) (14)



cpd:C02166 Leukotriene C4
cpd:C04598 2-Acetyl-1-alkyl-sn-glycero-3-phosphocholine
cpd:C05951 Leukotriene D4
hsa:6356 CCL11; chemokine (C-C motif) ligand 11
hsa:958 CD40; CD40 molecule, TNF receptor superfamily member 5
hsa:959 CD40LG; CD40 ligand
hsa:3109 HLA-DMB; major histocompatibility complex, class II, DM beta
hsa:3118 HLA-DQA2; major histocompatibility complex, class II, DQ alpha 2
hsa:3586 IL10; interleukin 10
hsa:3596 IL13; interleukin 13
hsa:3562 IL3; interleukin 3 (colony-stimulating factor, multiple)
hsa:3565 IL4; interleukin 4
hsa:3567 IL5; interleukin 5 (colony-stimulating factor, eosinophil)
hsa:7124 TNF; tumor necrosis factor

hsa00052 Galactose metabolism - Homo sapiens (human) (13)



cpd:C00031 D-Glucose
cpd:C00124 D-Galactose
cpd:C00159 D-Mannose
cpd:C00243 Lactose
hsa:231 AKR1B1; aldo-keto reductase family 1, member B1 (aldose reductase) (EC:1.1.1.21)
hsa:2538 G6PC; glucose-6-phosphatase, catalytic subunit (EC:3.1.3.9)
hsa:2592 GALT; galactose-1-phosphate uridylyltransferase (EC:2.7.7.12)
hsa:3098 HK1; hexokinase 1 (EC:2.7.1.1)
hsa:3099 HK2; hexokinase 2 (EC:2.7.1.1)
hsa:3101 HK3; hexokinase 3 (white cell) (EC:2.7.1.1)
hsa:5211 PFKL; phosphofructokinase, liver (EC:2.7.1.11)
hsa:5214 PFKP; phosphofructokinase, platelet (EC:2.7.1.11)
hsa:55276 PGM2; phosphoglucomutase 2 (EC:5.4.2.2 5.4.2.7)

hsa05340 Primary immunodeficiency - Homo sapiens (human) (13)



hsa:100 ADA; adenosine deaminase (EC:3.5.4.4)
hsa:29760 BLNK; B-cell linker
hsa:920 CD4; CD4 molecule
hsa:958 CD40; CD40 molecule, TNF receptor superfamily member 5
hsa:959 CD40LG; CD40 ligand
hsa:4261 CIITA; class II, major histocompatibility complex, transactivator
hsa:29851 ICOS; inducible T-cell co-stimulator
hsa:3561 IL2RG; interleukin 2 receptor, gamma
hsa:3575 IL7R; interleukin 7 receptor
hsa:3718 JAK3; Janus kinase 3 (EC:2.7.10.2)
hsa:3932 LCK; lymphocyte-specific protein tyrosine kinase (EC:2.7.10.2)
hsa:6890 TAP1; transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
hsa:6891 TAP2; transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)

hsa04260 Cardiac muscle contraction - Homo sapiens (human) (13)



cpd:C00238 Potassium cation
hsa:481 ATP1B1; ATPase, Na+/K+ transporting, beta 1 polypeptide
hsa:482 ATP1B2; ATPase, Na+/K+ transporting, beta 2 polypeptide (EC:3.6.3.9)
hsa:483 ATP1B3; ATPase, Na+/K+ transporting, beta 3 polypeptide (EC:3.6.3.9)
hsa:4514 COX3; cytochrome c oxidase III
hsa:1350 COX7C; cytochrome c oxidase subunit VIIc (EC:1.9.3.1)
hsa:4519 CYTB; cytochrome b
hsa:4624 MYH6; myosin, heavy chain 6, cardiac muscle, alpha
hsa:7137 TNNI3; troponin I type 3 (cardiac)
hsa:7168 TPM1; tropomyosin 1 (alpha)
hsa:7169 TPM2; tropomyosin 2 (beta)
hsa:7170 TPM3; tropomyosin 3
hsa:7171 TPM4; tropomyosin 4

hsa00280 Valine, leucine and isoleucine degradation - Homo sapiens (human) (12)



cpd:C00356 (S)-3-Hydroxy-3-methylglutaryl-CoA
hsa:38 ACAT1; acetyl-CoA acetyltransferase 1 (EC:2.3.1.9)
hsa:219 ALDH1B1; aldehyde dehydrogenase 1 family, member B1 (EC:1.2.1.3)
hsa:4329 ALDH6A1; aldehyde dehydrogenase 6 family, member A1 (EC:1.2.1.27 1.2.1.18)
hsa:501 ALDH7A1; aldehyde dehydrogenase 7 family, member A1 (EC:1.2.1.3 1.2.1.8 1.2.1.31)
hsa:223 ALDH9A1; aldehyde dehydrogenase 9 family, member A1 (EC:1.2.1.3 1.2.1.19 1.2.1.47)
hsa:1892 ECHS1; enoyl CoA hydratase, short chain, 1, mitochondrial (EC:4.2.1.17)
hsa:3030 HADHA; hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit (EC:4.2.1.17 1.1.1.211)
hsa:3157 HMGCS1; 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) (EC:2.3.3.10)
hsa:3158 HMGCS2; 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) (EC:2.3.3.10)
hsa:3028 HSD17B10; hydroxysteroid (17-beta) dehydrogenase 10 (EC:1.1.1.35 1.1.1.178)
hsa:5096 PCCB; propionyl CoA carboxylase, beta polypeptide (EC:6.4.1.3)

hsa00260 Glycine, serine and threonine metabolism - Homo sapiens (human) (12)



cpd:C00065 L-Serine
cpd:C00078 L-Tryptophan
cpd:C00114 Choline
cpd:C02737 Phosphatidylserine
hsa:501 ALDH7A1; aldehyde dehydrogenase 7 family, member A1 (EC:1.2.1.3 1.2.1.8 1.2.1.31)
hsa:2593 GAMT; guanidinoacetate N-methyltransferase (EC:2.1.1.2)
hsa:4128 MAOA; monoamine oxidase A (EC:1.4.3.4)
hsa:5223 PGAM1; phosphoglycerate mutase 1 (brain) (EC:3.1.3.13 5.4.2.1 5.4.2.4)
hsa:5224 PGAM2; phosphoglycerate mutase 2 (muscle) (EC:3.1.3.13 5.4.2.1 5.4.2.4)
hsa:26227 PHGDH; phosphoglycerate dehydrogenase (EC:1.1.1.95)
hsa:6470 SHMT1; serine hydroxymethyltransferase 1 (soluble) (EC:2.1.2.1)
hsa:63826 SRR; serine racemase (EC:4.3.1.17 5.1.1.18 4.3.1.18)

hsa00500 Starch and sucrose metabolism - Homo sapiens (human) (12)



cpd:C00031 D-Glucose
hsa:279 AMY2A; amylase, alpha 2A (pancreatic) (EC:3.2.1.1)
hsa:5167 ENPP1; ectonucleotide pyrophosphatase/phosphodiesterase 1 (EC:3.1.4.1 3.6.1.9)
hsa:2538 G6PC; glucose-6-phosphatase, catalytic subunit (EC:3.1.3.9)
hsa:2821 GPI; glucose-6-phosphate isomerase (EC:5.3.1.9)
hsa:2990 GUSB; glucuronidase, beta (EC:3.2.1.31)
hsa:2997 GYS1; glycogen synthase 1 (muscle) (EC:2.4.1.11)
hsa:3098 HK1; hexokinase 1 (EC:2.7.1.1)
hsa:3099 HK2; hexokinase 2 (EC:2.7.1.1)
hsa:3101 HK3; hexokinase 3 (white cell) (EC:2.7.1.1)
hsa:55276 PGM2; phosphoglucomutase 2 (EC:5.4.2.2 5.4.2.7)
hsa:5836 PYGL; phosphorylase, glycogen, liver (EC:2.4.1.1)

hsa00051 Fructose and mannose metabolism - Homo sapiens (human) (12)



cpd:C00159 D-Mannose
hsa:231 AKR1B1; aldo-keto reductase family 1, member B1 (aldose reductase) (EC:1.1.1.21)
hsa:226 ALDOA; aldolase A, fructose-bisphosphate (EC:4.1.2.13)
hsa:229 ALDOB; aldolase B, fructose-bisphosphate (EC:4.1.2.13)
hsa:8790 FPGT; fucose-1-phosphate guanylyltransferase (EC:2.7.7.30)
hsa:3098 HK1; hexokinase 1 (EC:2.7.1.1)
hsa:3099 HK2; hexokinase 2 (EC:2.7.1.1)
hsa:3101 HK3; hexokinase 3 (white cell) (EC:2.7.1.1)
hsa:5209 PFKFB3; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (EC:2.7.1.105 3.1.3.46)
hsa:5211 PFKL; phosphofructokinase, liver (EC:2.7.1.11)
hsa:5214 PFKP; phosphofructokinase, platelet (EC:2.7.1.11)
hsa:7167 TPI1; triosephosphate isomerase 1 (EC:5.3.1.1)

hsa00350 Tyrosine metabolism - Homo sapiens (human) (12)



cpd:C00355 3,4-Dihydroxy-L-phenylalanine
cpd:C00547 L-Noradrenaline
cpd:C01829 Thyroxine
cpd:C03758 Dopamine
cpd:C05582 Homovanillate
ec:5.3.3.12 L-dopachrome isomerase; dopachrome tautomerase; tyrosinase-related protein 2; TRP-1; TRP2; TRP-2; tyrosinase-related protein-2; dopachrome Delta7,Delta2-isomerase; dopachrome Delta-isomerase; dopachrome conversion factor; dopachrome isomerase; dopachrome oxidoreductase; dopachrome-rearranging enzyme; DCF; DCT; dopachrome keto-enol isomerase; L-dopachrome-methyl ester tautomerase
hsa:1638 DCT; dopachrome tautomerase (dopachrome delta-isomerase, tyrosine-related protein 2) (EC:5.3.3.12)
hsa:1644 DDC; dopa decarboxylase (aromatic L-amino acid decarboxylase) (EC:4.1.1.28)
hsa:2184 FAH; fumarylacetoacetate hydrolase (fumarylacetoacetase) (EC:3.7.1.2)
hsa:4128 MAOA; monoamine oxidase A (EC:1.4.3.4)
hsa:4282 MIF; macrophage migration inhibitory factor (glycosylation-inhibiting factor) (EC:5.3.3.12 5.3.2.1)
hsa:7054 TH; tyrosine hydroxylase (EC:1.14.16.2) (FROM T.GONDII) 

hsa00561 Glycerolipid metabolism - Homo sapiens (human) (12)



hsa:84803 AGPAT9; 1-acylglycerol-3-phosphate O-acyltransferase 9 (EC:2.3.1.15)
hsa:231 AKR1B1; aldo-keto reductase family 1, member B1 (aldose reductase) (EC:1.1.1.21)
hsa:219 ALDH1B1; aldehyde dehydrogenase 1 family, member B1 (EC:1.2.1.3)
hsa:501 ALDH7A1; aldehyde dehydrogenase 7 family, member A1 (EC:1.2.1.3 1.2.1.8 1.2.1.31)
hsa:223 ALDH9A1; aldehyde dehydrogenase 9 family, member A1 (EC:1.2.1.3 1.2.1.19 1.2.1.47)
hsa:26007 DAK; dihydroxyacetone kinase 2 homolog (S. cerevisiae) (EC:2.7.1.29 4.6.1.15)
hsa:8525 DGKZ; diacylglycerol kinase, zeta (EC:2.7.1.107)
hsa:2710 GK; glycerol kinase (EC:2.7.1.30)
hsa:23175 LPIN1; lipin 1 (EC:3.1.3.4)
hsa:9663 LPIN2; lipin 2 (EC:3.1.3.4)
hsa:4023 LPL; lipoprotein lipase (EC:3.1.1.34)
hsa:11343 MGLL; monoglyceride lipase (EC:3.1.1.23)

hsa04140 Regulation of autophagy - Homo sapiens (human) (11)



cpd:C00350 Phosphatidylethanolamine
cpd:C01194 1-Phosphatidyl-D-myo-inositol
hsa:9474 ATG5; ATG5 autophagy related 5 homolog (S. cerevisiae)
hsa:10533 ATG7; ATG7 autophagy related 7 homolog (S. cerevisiae)
hsa:8678 BECN1; beclin 1, autophagy related
hsa:23710 GABARAPL1; GABA(A) receptor-associated protein like 1
hsa:3439 IFNA1; interferon, alpha 1
hsa:3443 IFNA6; interferon, alpha 6
hsa:3458 IFNG; interferon, gamma
hsa:3630 INS; insulin
hsa:5289 PIK3C3; phosphoinositide-3-kinase, class 3 (EC:2.7.1.137)

hsa00410 beta-Alanine metabolism - Homo sapiens (human) (11)



cpd:C00315 Spermidine
cpd:C00750 Spermine
hsa:219 ALDH1B1; aldehyde dehydrogenase 1 family, member B1 (EC:1.2.1.3)
hsa:4329 ALDH6A1; aldehyde dehydrogenase 6 family, member A1 (EC:1.2.1.27 1.2.1.18)
hsa:501 ALDH7A1; aldehyde dehydrogenase 7 family, member A1 (EC:1.2.1.3 1.2.1.8 1.2.1.31)
hsa:223 ALDH9A1; aldehyde dehydrogenase 9 family, member A1 (EC:1.2.1.3 1.2.1.19 1.2.1.47)
hsa:55748 CNDP2; CNDP dipeptidase 2 (metallopeptidase M20 family) (EC:3.4.13.18)
hsa:1806 DPYD; dihydropyrimidine dehydrogenase (EC:1.3.1.2)
hsa:1892 ECHS1; enoyl CoA hydratase, short chain, 1, mitochondrial (EC:4.2.1.17)
hsa:3030 HADHA; hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit (EC:4.2.1.17 1.1.1.211)
hsa:6723 SRM; spermidine synthase (EC:2.5.1.16)

hsa03008 Ribosome biogenesis in eukaryotes - Homo sapiens (human) (10)



hsa:84916 CIRH1A; cirrhosis, autosomal recessive 1A (cirhin)
hsa:26354 GNL3; guanine nucleotide binding protein-like 3 (nucleolar)
hsa:92856 IMP4; IMP4, U3 small nucleolar ribonucleoprotein, homolog (yeast)
hsa:55341 LSG1; large subunit GTPase 1 homolog (S. cerevisiae)
hsa:4809 NHP2L1; NHP2 non-histone chromosome protein 2-like 1 (S. cerevisiae)
hsa:65083 NOL6; nucleolar protein family 6 (RNA-associated)
hsa:10248 POP7; processing of precursor 7, ribonuclease P/MRP subunit (S. cerevisiae) (EC:3.1.26.5)
hsa:5822 PWP2; PWP2 periodic tryptophan protein homolog (yeast)
hsa:55131 RBM28; RNA binding motif protein 28
hsa:10885 WDR3; WD repeat domain 3

hsa04964 Proximal tubule bicarbonate reclamation - Homo sapiens (human) (10)



cpd:C00064 L-Glutamine
cpd:C00238 Potassium cation
hsa:358 AQP1; aquaporin 1 (Colton blood group)
hsa:481 ATP1B1; ATPase, Na+/K+ transporting, beta 1 polypeptide
hsa:482 ATP1B2; ATPase, Na+/K+ transporting, beta 2 polypeptide (EC:3.6.3.9)
hsa:483 ATP1B3; ATPase, Na+/K+ transporting, beta 3 polypeptide (EC:3.6.3.9)
hsa:2744 GLS; glutaminase (EC:3.5.1.2)
hsa:27165 GLS2; glutaminase 2 (liver, mitochondrial) (EC:3.5.1.2)
hsa:4190 MDH1; malate dehydrogenase 1, NAD (soluble) (EC:1.1.1.37)
hsa:5105 PCK1; phosphoenolpyruvate carboxykinase 1 (soluble) (EC:4.1.1.32)

hsa00640 Propanoate metabolism - Homo sapiens (human) (10)



hsa:38 ACAT1; acetyl-CoA acetyltransferase 1 (EC:2.3.1.9)
hsa:219 ALDH1B1; aldehyde dehydrogenase 1 family, member B1 (EC:1.2.1.3)
hsa:4329 ALDH6A1; aldehyde dehydrogenase 6 family, member A1 (EC:1.2.1.27 1.2.1.18)
hsa:501 ALDH7A1; aldehyde dehydrogenase 7 family, member A1 (EC:1.2.1.3 1.2.1.8 1.2.1.31)
hsa:223 ALDH9A1; aldehyde dehydrogenase 9 family, member A1 (EC:1.2.1.3 1.2.1.19 1.2.1.47)
hsa:1892 ECHS1; enoyl CoA hydratase, short chain, 1, mitochondrial (EC:4.2.1.17)
hsa:3030 HADHA; hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit (EC:4.2.1.17 1.1.1.211)
hsa:3939 LDHA; lactate dehydrogenase A (EC:1.1.1.27)
hsa:5096 PCCB; propionyl CoA carboxylase, beta polypeptide (EC:6.4.1.3)
hsa:8802 SUCLG1; succinate-CoA ligase, alpha subunit (EC:6.2.1.4 6.2.1.5)

hsa00630 Glyoxylate and dicarboxylate metabolism - Homo sapiens (human) (10)



cpd:C00027 Hydrogen peroxide
cpd:C00065 L-Serine
hsa:38 ACAT1; acetyl-CoA acetyltransferase 1 (EC:2.3.1.9)
hsa:48 ACO1; aconitase 1, soluble (EC:4.2.1.3)
hsa:50 ACO2; aconitase 2, mitochondrial (EC:4.2.1.3)
hsa:847 CAT; catalase (EC:1.11.1.6)
hsa:1431 CS; citrate synthase (EC:2.3.3.1)
hsa:4190 MDH1; malate dehydrogenase 1, NAD (soluble) (EC:1.1.1.37)
hsa:5096 PCCB; propionyl CoA carboxylase, beta polypeptide (EC:6.4.1.3)
hsa:6470 SHMT1; serine hydroxymethyltransferase 1 (soluble) (EC:2.1.2.1)

hsa05216 Thyroid cancer - Homo sapiens (human) (10)



hsa:8030 CCDC6; coiled-coil domain containing 6
hsa:595 CCND1; cyclin D1
hsa:5605 MAP2K2; mitogen-activated protein kinase kinase 2 (EC:2.7.12.2)
hsa:5594 MAPK1; mitogen-activated protein kinase 1 (EC:2.7.11.24)
hsa:5595 MAPK3; mitogen-activated protein kinase 3 (EC:2.7.11.24)
hsa:4609 MYC; v-myc myelocytomatosis viral oncogene homolog (avian)
hsa:8031 NCOA4; nuclear receptor coactivator 4
hsa:5468 PPARG; peroxisome proliferator-activated receptor gamma
hsa:6934 TCF7L2; transcription factor 7-like 2 (T-cell specific, HMG-box)
hsa:7170 TPM3; tropomyosin 3

hsa04721 Synaptic vesicle cycle - Homo sapiens (human) (10)



cpd:C00002 ATP
cpd:C00547 L-Noradrenaline
cpd:C03758 Dopamine
hsa:160 AP2A1; adaptor-related protein complex 2, alpha 1 subunit
hsa:535 ATP6V0A1; ATPase, H+ transporting, lysosomal V0 subunit a1 (EC:3.6.3.14)
hsa:533 ATP6V0B; ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b (EC:3.6.3.14)
hsa:245972 ATP6V0D2; ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2 (EC:3.6.3.14)
hsa:523 ATP6V1A; ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A (EC:3.6.3.14)
hsa:1211 CLTA; clathrin, light chain A
hsa:1759 DNM1; dynamin 1 (EC:3.6.5.5)

hsa03040 Spliceosome - Homo sapiens (human) (10)



hsa:3183 HNRNPC; heterogeneous nuclear ribonucleoprotein C (C1/C2)
hsa:3190 HNRNPK; heterogeneous nuclear ribonucleoprotein K
hsa:4670 HNRNPM; heterogeneous nuclear ribonucleoprotein M
hsa:3312 HSPA8; heat shock 70kDa protein 8
hsa:55110 MAGOHB; mago-nashi homolog B (Drosophila)
hsa:4809 NHP2L1; NHP2 non-histone chromosome protein 2-like 1 (S. cerevisiae)
hsa:5093 PCBP1; poly(rC) binding protein 1
hsa:10084 PQBP1; polyglutamine binding protein 1
hsa:9092 SART1; squamous cell carcinoma antigen recognized by T cells
hsa:10946 SF3A3; splicing factor 3a, subunit 3, 60kDa

hsa03050 Proteasome - Homo sapiens (human) (10)



hsa:3458 IFNG; interferon, gamma
hsa:5683 PSMA2; proteasome (prosome, macropain) subunit, alpha type, 2 (EC:3.4.25.1)
hsa:5684 PSMA3; proteasome (prosome, macropain) subunit, alpha type, 3 (EC:3.4.25.1)
hsa:5685 PSMA4; proteasome (prosome, macropain) subunit, alpha type, 4 (EC:3.4.25.1)
hsa:5699 PSMB10; proteasome (prosome, macropain) subunit, beta type, 10 (EC:3.4.25.1)
hsa:5696 PSMB8; proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7) (EC:3.4.25.1)
hsa:5698 PSMB9; proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2) (EC:3.4.25.1)
hsa:10213 PSMD14; proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 (EC:3.1.2.15)
hsa:5720 PSME1; proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
hsa:5721 PSME2; proteasome (prosome, macropain) activator subunit 2 (PA28 beta)

hsa04962 Vasopressin-regulated water reabsorption - Homo sapiens (human) (9)



cpd:C00575 3',5'-Cyclic AMP
hsa:109 ADCY3; adenylate cyclase 3 (EC:4.6.1.1)
hsa:112 ADCY6; adenylate cyclase 6 (EC:4.6.1.1)
hsa:1385 CREB1; cAMP responsive element binding protein 1
hsa:10488 CREB3; cAMP responsive element binding protein 3
hsa:9586 CREB5; cAMP responsive element binding protein 5
hsa:10540 DCTN2; dynactin 2 (p50)
hsa:1781 DYNC1I2; dynein, cytoplasmic 1, intermediate chain 2
hsa:5869 RAB5B; RAB5B, member RAS oncogene family

hsa00620 Pyruvate metabolism - Homo sapiens (human) (9)



hsa:38 ACAT1; acetyl-CoA acetyltransferase 1 (EC:2.3.1.9)
hsa:231 AKR1B1; aldo-keto reductase family 1, member B1 (aldose reductase) (EC:1.1.1.21)
hsa:219 ALDH1B1; aldehyde dehydrogenase 1 family, member B1 (EC:1.2.1.3)
hsa:501 ALDH7A1; aldehyde dehydrogenase 7 family, member A1 (EC:1.2.1.3 1.2.1.8 1.2.1.31)
hsa:223 ALDH9A1; aldehyde dehydrogenase 9 family, member A1 (EC:1.2.1.3 1.2.1.19 1.2.1.47)
hsa:3939 LDHA; lactate dehydrogenase A (EC:1.1.1.27)
hsa:4190 MDH1; malate dehydrogenase 1, NAD (soluble) (EC:1.1.1.37)
hsa:5105 PCK1; phosphoenolpyruvate carboxykinase 1 (soluble) (EC:4.1.1.32)
hsa:5315 PKM2; pyruvate kinase, muscle (EC:2.7.1.40)

hsa00020 Citrate cycle (TCA cycle) - Homo sapiens (human) (9)



hsa:48 ACO1; aconitase 1, soluble (EC:4.2.1.3)
hsa:50 ACO2; aconitase 2, mitochondrial (EC:4.2.1.3)
hsa:1431 CS; citrate synthase (EC:2.3.3.1)
hsa:3417 IDH1; isocitrate dehydrogenase 1 (NADP+), soluble (EC:1.1.1.42)
hsa:3418 IDH2; isocitrate dehydrogenase 2 (NADP+), mitochondrial (EC:1.1.1.42)
hsa:3421 IDH3G; isocitrate dehydrogenase 3 (NAD+) gamma (EC:1.1.1.41)
hsa:4190 MDH1; malate dehydrogenase 1, NAD (soluble) (EC:1.1.1.37)
hsa:5105 PCK1; phosphoenolpyruvate carboxykinase 1 (soluble) (EC:4.1.1.32)
hsa:8802 SUCLG1; succinate-CoA ligase, alpha subunit (EC:6.2.1.4 6.2.1.5)

hsa00983 Drug metabolism - other enzymes - Homo sapiens (human) (8)



hsa:1806 DPYD; dihydropyrimidine dehydrogenase (EC:1.3.1.2)
hsa:2990 GUSB; glucuronidase, beta (EC:3.2.1.31)
hsa:3251 HPRT1; hypoxanthine phosphoribosyltransferase 1 (EC:2.4.2.8)
hsa:7083 TK1; thymidine kinase 1, soluble (EC:2.7.1.21)
hsa:1890 TYMP; thymidine phosphorylase (EC:2.4.2.4)
hsa:7372 UMPS; uridine monophosphate synthetase (EC:2.4.2.10 4.1.1.23)
hsa:7378 UPP1; uridine phosphorylase 1 (EC:2.4.2.3)
hsa:7498 XDH; xanthine dehydrogenase (EC:1.17.1.4 1.17.3.2)

hsa00900 Terpenoid backbone biosynthesis - Homo sapiens (human) (8)



cpd:C00356 (S)-3-Hydroxy-3-methylglutaryl-CoA
hsa:38 ACAT1; acetyl-CoA acetyltransferase 1 (EC:2.3.1.9)
hsa:2224 FDPS; farnesyl diphosphate synthase (EC:2.5.1.1 2.5.1.10)
hsa:2342 FNTB; farnesyltransferase, CAAX box, beta (EC:2.5.1.58)
hsa:3156 HMGCR; 3-hydroxy-3-methylglutaryl-CoA reductase (EC:1.1.1.34)
hsa:3157 HMGCS1; 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) (EC:2.3.3.10)
hsa:3158 HMGCS2; 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) (EC:2.3.3.10)
hsa:4597 MVD; mevalonate (diphospho) decarboxylase (EC:4.1.1.33)

hsa03018 RNA degradation - Homo sapiens (human) (8)



hsa:246175 CNOT6L; CCR4-NOT transcription complex, subunit 6-like
hsa:196513 DCP1B; DCP1 decapping enzyme homolog B (S. cerevisiae)
hsa:2023 ENO1; enolase 1, (alpha) (EC:4.2.1.11)
hsa:118460 EXOSC6; exosome component 6
hsa:3329 HSPD1; heat shock 60kDa protein 1 (chaperonin)
hsa:8761 PABPC4; poly(A) binding protein, cytoplasmic 4 (inducible form)
hsa:9924 PAN2; PAN2 poly(A) specific ribonuclease subunit homolog (S. cerevisiae) (EC:3.1.13.4)
hsa:219988 PATL1; protein associated with topoisomerase II homolog 1 (yeast)

hsa00030 Pentose phosphate pathway - Homo sapiens (human) (8)



cpd:C00031 D-Glucose
hsa:226 ALDOA; aldolase A, fructose-bisphosphate (EC:4.1.2.13)
hsa:229 ALDOB; aldolase B, fructose-bisphosphate (EC:4.1.2.13)
hsa:2821 GPI; glucose-6-phosphate isomerase (EC:5.3.1.9)
hsa:5211 PFKL; phosphofructokinase, liver (EC:2.7.1.11)
hsa:5214 PFKP; phosphofructokinase, platelet (EC:2.7.1.11)
hsa:25796 PGLS; 6-phosphogluconolactonase (EC:3.1.1.31)
hsa:55276 PGM2; phosphoglucomutase 2 (EC:5.4.2.2 5.4.2.7)

hsa00760 Nicotinate and nicotinamide metabolism - Homo sapiens (human) (8)



hsa:683 BST1; bone marrow stromal cell antigen 1 (EC:3.2.2.5)
hsa:952 CD38; CD38 molecule (EC:3.2.2.5)
hsa:5167 ENPP1; ectonucleotide pyrophosphatase/phosphodiesterase 1 (EC:3.1.4.1 3.6.1.9)
hsa:10135 NAMPT; nicotinamide phosphoribosyltransferase (EC:2.4.2.12)
hsa:93100 NAPRT1; nicotinate phosphoribosyltransferase domain containing 1 (EC:2.4.2.11)
hsa:93034 NT5C1B; 5'-nucleotidase, cytosolic IB (EC:3.1.3.5)
hsa:4907 NT5E; 5'-nucleotidase, ecto (CD73) (EC:3.1.3.5)
hsa:4860 PNP; purine nucleoside phosphorylase (EC:2.4.2.1)

hsa03020 RNA polymerase - Homo sapiens (human) (8)



hsa:25885 POLR1A; polymerase (RNA) I polypeptide A, 194kDa (EC:2.7.7.6)
hsa:84172 POLR1B; polymerase (RNA) I polypeptide B, 128kDa (EC:2.7.7.6)
hsa:9533 POLR1C; polymerase (RNA) I polypeptide C, 30kDa
hsa:51082 POLR1D; polymerase (RNA) I polypeptide D, 16kDa
hsa:64425 POLR1E; polymerase (RNA) I polypeptide E, 53kDa
hsa:55718 POLR3E; polymerase (RNA) III (DNA directed) polypeptide E (80kD)
hsa:51728 POLR3K; polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
hsa:221830 TWISTNB; TWIST neighbor

hsa00250 Alanine, aspartate and glutamate metabolism - Homo sapiens (human) (8)



cpd:C00064 L-Glutamine
hsa:445 ASS1; argininosuccinate synthase 1 (EC:6.3.4.5)
hsa:2673 GFPT1; glutamine--fructose-6-phosphate transaminase 1 (EC:2.6.1.16)
hsa:2744 GLS; glutaminase (EC:3.5.1.2)
hsa:27165 GLS2; glutaminase 2 (liver, mitochondrial) (EC:3.5.1.2)
hsa:2752 GLUL; glutamate-ammonia ligase (EC:4.1.1.15 6.3.1.2)
hsa:56954 NIT2; nitrilase family, member 2 (EC:3.5.1.3)
hsa:5471 PPAT; phosphoribosyl pyrophosphate amidotransferase (EC:2.4.2.14)

hsa03410 Base excision repair - Homo sapiens (human) (8)



hsa:3146 HMGB1; high mobility group box 1
hsa:3978 LIG1; ligase I, DNA, ATP-dependent (EC:6.5.1.1)
hsa:142 PARP1; poly (ADP-ribose) polymerase 1 (EC:2.4.2.30)
hsa:10038 PARP2; poly (ADP-ribose) polymerase 2 (EC:2.4.2.30)
hsa:5111 PCNA; proliferating cell nuclear antigen
hsa:5423 POLB; polymerase (DNA directed), beta (EC:2.7.7.7)
hsa:54107 POLE3; polymerase (DNA directed), epsilon 3 (p17 subunit) (EC:2.7.7.7)
hsa:23583 SMUG1; single-strand-selective monofunctional uracil-DNA glycosylase 1

hsa05217 Basal cell carcinoma - Homo sapiens (human) (8)



hsa:8313 AXIN2; axin 2
hsa:650 BMP2; bone morphogenetic protein 2
hsa:8322 FZD4; frizzled family receptor 4
hsa:8324 FZD7; frizzled family receptor 7
hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26)
hsa:64399 HHIP; hedgehog interacting protein
hsa:6934 TCF7L2; transcription factor 7-like 2 (T-cell specific, HMG-box)
hsa:7474 WNT5A; wingless-type MMTV integration site family, member 5A

hsa00980 Metabolism of xenobiotics by cytochrome P450 - Homo sapiens (human) (8)



hsa:873 CBR1; carbonyl reductase 1 (EC:1.1.1.189 1.1.1.197 1.1.1.184)
hsa:1545 CYP1B1; cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1)
hsa:2939 GSTA2; glutathione S-transferase alpha 2 (EC:2.5.1.18)
hsa:2940 GSTA3; glutathione S-transferase alpha 3 (EC:2.5.1.18)
hsa:2944 GSTM1; glutathione S-transferase mu 1 (EC:2.5.1.18)
hsa:2947 GSTM3; glutathione S-transferase mu 3 (brain) (EC:2.5.1.18)
hsa:2948 GSTM4; glutathione S-transferase mu 4 (EC:2.5.1.18)
hsa:2949 GSTM5; glutathione S-transferase mu 5 (EC:2.5.1.18)

hsa00340 Histidine metabolism - Homo sapiens (human) (7)



hsa:219 ALDH1B1; aldehyde dehydrogenase 1 family, member B1 (EC:1.2.1.3)
hsa:501 ALDH7A1; aldehyde dehydrogenase 7 family, member A1 (EC:1.2.1.3 1.2.1.8 1.2.1.31)
hsa:223 ALDH9A1; aldehyde dehydrogenase 9 family, member A1 (EC:1.2.1.3 1.2.1.19 1.2.1.47)
hsa:55748 CNDP2; CNDP dipeptidase 2 (metallopeptidase M20 family) (EC:3.4.13.18)
hsa:1644 DDC; dopa decarboxylase (aromatic L-amino acid decarboxylase) (EC:4.1.1.28)
hsa:3176 HNMT; histamine N-methyltransferase (EC:2.1.1.8)
hsa:4128 MAOA; monoamine oxidase A (EC:1.4.3.4)

hsa04340 Hedgehog signaling pathway - Homo sapiens (human) (7)



hsa:650 BMP2; bone morphogenetic protein 2
hsa:654 BMP6; bone morphogenetic protein 6
hsa:2619 GAS1; growth arrest-specific 1
hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26)
hsa:64399 HHIP; hedgehog interacting protein
hsa:3549 IHH; Indian hedgehog
hsa:7474 WNT5A; wingless-type MMTV integration site family, member 5A

hsa00650 Butanoate metabolism - Homo sapiens (human) (7)



cpd:C00356 (S)-3-Hydroxy-3-methylglutaryl-CoA
hsa:65985 AACS; acetoacetyl-CoA synthetase (EC:6.2.1.16)
hsa:38 ACAT1; acetyl-CoA acetyltransferase 1 (EC:2.3.1.9)
hsa:1892 ECHS1; enoyl CoA hydratase, short chain, 1, mitochondrial (EC:4.2.1.17)
hsa:3030 HADHA; hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit (EC:4.2.1.17 1.1.1.211)
hsa:3157 HMGCS1; 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) (EC:2.3.3.10)
hsa:3158 HMGCS2; 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) (EC:2.3.3.10)

hsa00270 Cysteine and methionine metabolism - Homo sapiens (human) (7)



cpd:C00051 Glutathione
cpd:C00065 L-Serine
hsa:1788 DNMT3A; DNA (cytosine-5-)-methyltransferase 3 alpha (EC:2.1.1.37)
hsa:1789 DNMT3B; DNA (cytosine-5-)-methyltransferase 3 beta (EC:2.1.1.37)
hsa:3939 LDHA; lactate dehydrogenase A (EC:1.1.1.27)
hsa:4507 MTAP; methylthioadenosine phosphorylase (EC:2.4.2.28)
hsa:6723 SRM; spermidine synthase (EC:2.5.1.16)

hsa00982 Drug metabolism - cytochrome P450 - Homo sapiens (human) (7)



hsa:2939 GSTA2; glutathione S-transferase alpha 2 (EC:2.5.1.18)
hsa:2940 GSTA3; glutathione S-transferase alpha 3 (EC:2.5.1.18)
hsa:2944 GSTM1; glutathione S-transferase mu 1 (EC:2.5.1.18)
hsa:2947 GSTM3; glutathione S-transferase mu 3 (brain) (EC:2.5.1.18)
hsa:2948 GSTM4; glutathione S-transferase mu 4 (EC:2.5.1.18)
hsa:2949 GSTM5; glutathione S-transferase mu 5 (EC:2.5.1.18)
hsa:4128 MAOA; monoamine oxidase A (EC:1.4.3.4)

hsa00140 Steroid hormone biosynthesis - Homo sapiens (human) (7)



cpd:C00535 Testosterone
cpd:C00951 Estradiol-17beta
cpd:C01227 Dehydroepiandrosterone
hsa:1545 CYP1B1; cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1)
hsa:9420 CYP7B1; cytochrome P450, family 7, subfamily B, polypeptide 1 (EC:1.14.13.100)
hsa:3294 HSD17B2; hydroxysteroid (17-beta) dehydrogenase 2 (EC:1.1.1.62 1.1.1.63)
hsa:8630 HSD17B6; hydroxysteroid (17-beta) dehydrogenase 6 homolog (mouse) (EC:1.1.1.62 1.1.1.63 1.1.1.105)

hsa00970 Aminoacyl-tRNA biosynthesis - Homo sapiens (human) (7)



cpd:C00062 L-Arginine
cpd:C00064 L-Glutamine
cpd:C00065 L-Serine
cpd:C00078 L-Tryptophan
hsa:3735 KARS; lysyl-tRNA synthetase (EC:6.1.1.6)
hsa:51091 SEPSECS; Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase (EC:2.9.1.2)
hsa:7453 WARS; tryptophanyl-tRNA synthetase (EC:6.1.1.2)

hsa00670 One carbon pool by folate - Homo sapiens (human) (6)



cpd:C00504 Folate
hsa:4522 MTHFD1; methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase (EC:1.5.1.5 6.3.4.3 3.5.4.9)
hsa:25902 MTHFD1L; methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like (EC:6.3.4.3)
hsa:10797 MTHFD2; methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase (EC:3.5.4.9 1.5.1.15)
hsa:6470 SHMT1; serine hydroxymethyltransferase 1 (soluble) (EC:2.1.2.1)
hsa:7298 TYMS; thymidylate synthetase (EC:2.1.1.45)

hsa01040 Biosynthesis of unsaturated fatty acids - Homo sapiens (human) (6)



cpd:C00219 Arachidonate
cpd:C00249 Hexadecanoic acid
hsa:51 ACOX1; acyl-CoA oxidase 1, palmitoyl (EC:1.3.3.6)
hsa:3992 FADS1; fatty acid desaturase 1 (EC:1.14.19.-)
hsa:9415 FADS2; fatty acid desaturase 2 (EC:1.14.19.-)
hsa:3030 HADHA; hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit (EC:4.2.1.17 1.1.1.211)

hsa04330 Notch signaling pathway - Homo sapiens (human) (6)



hsa:1488 CTBP2; C-terminal binding protein 2
hsa:23220 DTX4; deltex homolog 4 (Drosophila)
hsa:182 JAG1; jagged 1
hsa:4854 NOTCH3; notch 3
hsa:55851 PSENEN; presenilin enhancer 2 homolog (C. elegans)
hsa:171558 PTCRA; pre T-cell antigen receptor alpha
hsa03420 Nucleotide excision repair - Homo sapiens (human) (6)



hsa:1642 DDB1; damage-specific DNA binding protein 1, 127kDa
hsa:1643 DDB2; damage-specific DNA binding protein 2, 48kDa
hsa:3978 LIG1; ligase I, DNA, ATP-dependent (EC:6.5.1.1)
hsa:5111 PCNA; proliferating cell nuclear antigen
hsa:54107 POLE3; polymerase (DNA directed), epsilon 3 (p17 subunit) (EC:2.7.7.7)
hsa:5887 RAD23B; RAD23 homolog B (S. cerevisiae)

hsa00591 Linoleic acid metabolism - Homo sapiens (human) (6)



cpd:C00157 Phosphatidylcholine
cpd:C00219 Arachidonate
cpd:C14762 13(S)-HODE
cpd:C14767 9(S)-HODE
hsa:246 ALOX15; arachidonate 15-lipoxygenase (EC:1.13.11.33)
hsa:5321 PLA2G4A; phospholipase A2, group IVA (cytosolic, calcium-dependent) (EC:3.1.1.5 3.1.1.4)

hsa04742 Taste transduction - Homo sapiens (human) (6)



cpd:C00238 Potassium cation
cpd:C00575 3',5'-Cyclic AMP
hsa:112 ADCY6; adenylate cyclase 6 (EC:4.6.1.1)
hsa:5330 PLCB2; phospholipase C, beta 2 (EC:3.1.4.11)
hsa:259285 TAS2R39; taste receptor, type 2, member 39
hsa:259289 TAS2R43; taste receptor, type 2, member 43

hsa00310 Lysine degradation - Homo sapiens (human) (6)



hsa:38 ACAT1; acetyl-CoA acetyltransferase 1 (EC:2.3.1.9)
hsa:219 ALDH1B1; aldehyde dehydrogenase 1 family, member B1 (EC:1.2.1.3)
hsa:501 ALDH7A1; aldehyde dehydrogenase 7 family, member A1 (EC:1.2.1.3 1.2.1.8 1.2.1.31)
hsa:223 ALDH9A1; aldehyde dehydrogenase 9 family, member A1 (EC:1.2.1.3 1.2.1.19 1.2.1.47)
hsa:1892 ECHS1; enoyl CoA hydratase, short chain, 1, mitochondrial (EC:4.2.1.17)
hsa:3030 HADHA; hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit (EC:4.2.1.17 1.1.1.211)

hsa00565 Ether lipid metabolism - Homo sapiens (human) (6)



cpd:C04598 2-Acetyl-1-alkyl-sn-glycero-3-phosphocholine
hsa:79888 LPCAT1; lysophosphatidylcholine acyltransferase 1 (EC:2.3.1.23 2.3.1.67)
hsa:254531 LPCAT4; lysophosphatidylcholine acyltransferase 4 (EC:2.3.1.51)
hsa:5048 PAFAH1B1; platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) (EC:3.1.1.47)
hsa:5321 PLA2G4A; phospholipase A2, group IVA (cytosolic, calcium-dependent) (EC:3.1.1.5 3.1.1.4)
hsa:5337 PLD1; phospholipase D1, phosphatidylcholine-specific (EC:3.1.4.4)

hsa04977 Vitamin digestion and absorption - Homo sapiens (human) (6)



cpd:C00018 Pyridoxal phosphate
cpd:C00504 Folate
cpd:C02477 alpha-Tocopherol
hsa:2346 FOLH1; folate hydrolase (prostate-specific membrane antigen) 1 (EC:3.4.17.21)
hsa:80704 SLC19A3; solute carrier family 19, member 3
hsa:8884 SLC5A6; solute carrier family 5 (sodium-dependent vitamin transporter), member 6

hsa03030 DNA replication - Homo sapiens (human) (5)



hsa:1763 DNA2; DNA replication helicase 2 homolog (yeast) (EC:3.6.4.12)
hsa:3978 LIG1; ligase I, DNA, ATP-dependent (EC:6.5.1.1)
hsa:5111 PCNA; proliferating cell nuclear antigen
hsa:54107 POLE3; polymerase (DNA directed), epsilon 3 (p17 subunit) (EC:2.7.7.7)
hsa:5557 PRIM1; primase, DNA, polypeptide 1 (49kDa) (EC:2.7.7.-)

hsa00600 Sphingolipid metabolism - Homo sapiens (human) (5)



cpd:C00065 L-Serine
cpd:C00195 N-Acylsphingosine
hsa:64781 CERK; ceramide kinase (EC:2.7.1.138)
hsa:8879 SGPL1; sphingosine-1-phosphate lyase 1 (EC:4.1.2.27)
hsa:55512 SMPD3; sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II) (EC:3.1.4.12)

hsa00510 N-Glycan biosynthesis - Homo sapiens (human) (5)



hsa:56052 ALG1; asparagine-linked glycosylation 1, beta-1,4-mannosyltransferase homolog (S. cerevisiae) (EC:2.4.1.142)
hsa:1603 DAD1; defender against cell death 1 (EC:2.4.1.119)
hsa:8813 DPM1; dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit (EC:2.4.1.83)
hsa:4122 MAN2A2; mannosidase, alpha, class 2A, member 2 (EC:3.2.1.114)
hsa:6480 ST6GAL1; ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 (EC:2.4.99.1)

hsa00860 Porphyrin and chlorophyll metabolism - Homo sapiens (human) (5)



hsa:644 BLVRA; biliverdin reductase A (EC:1.3.1.24)
hsa:645 BLVRB; biliverdin reductase B (flavin reductase (NADPH)) (EC:1.3.1.24 1.5.1.30)
hsa:1371 CPOX; coproporphyrinogen oxidase (EC:1.3.3.3)
hsa:2990 GUSB; glucuronidase, beta (EC:3.2.1.31)
hsa:3162 HMOX1; heme oxygenase (decycling) 1 (EC:1.14.99.3)

hsa00592 alpha-Linolenic acid metabolism - Homo sapiens (human) (4)



cpd:C00157 Phosphatidylcholine
hsa:51 ACOX1; acyl-CoA oxidase 1, palmitoyl (EC:1.3.3.6)
hsa:9415 FADS2; fatty acid desaturase 2 (EC:1.14.19.-)
hsa:5321 PLA2G4A; phospholipase A2, group IVA (cytosolic, calcium-dependent) (EC:3.1.1.5 3.1.1.4)

hsa00360 Phenylalanine metabolism - Homo sapiens (human) (4)



hsa:1644 DDC; dopa decarboxylase (aromatic L-amino acid decarboxylase) (EC:4.1.1.28)
hsa:4128 MAOA; monoamine oxidase A (EC:1.4.3.4)
hsa:4282 MIF; macrophage migration inhibitory factor (glycosylation-inhibiting factor) (EC:5.3.3.12 5.3.2.1)
hsa:9588 PRDX6; peroxiredoxin 6 (EC:1.11.1.9 1.11.1.15)

hsa00830 Retinol metabolism - Homo sapiens (human) (4)



hsa:8854 ALDH1A2; aldehyde dehydrogenase 1 family, member A2 (EC:1.2.1.36)
hsa:9249 DHRS3; dehydrogenase/reductase (SDR family) member 3 (EC:1.1.1.300)
hsa:8630 HSD17B6; hydroxysteroid (17-beta) dehydrogenase 6 homolog (mouse) (EC:1.1.1.62 1.1.1.63 1.1.1.105)
hsa:50700 RDH8; retinol dehydrogenase 8 (all-trans) (EC:1.1.1.300)

hsa00072 Synthesis and degradation of ketone bodies - Homo sapiens (human) (4)



cpd:C00356 (S)-3-Hydroxy-3-methylglutaryl-CoA
hsa:38 ACAT1; acetyl-CoA acetyltransferase 1 (EC:2.3.1.9)
hsa:3157 HMGCS1; 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) (EC:2.3.3.10)
hsa:3158 HMGCS2; 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) (EC:2.3.3.10)

hsa04966 Collecting duct acid secretion - Homo sapiens (human) (4)



cpd:C00238 Potassium cation
hsa:535 ATP6V0A1; ATPase, H+ transporting, lysosomal V0 subunit a1 (EC:3.6.3.14)
hsa:245972 ATP6V0D2; ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2 (EC:3.6.3.14)
hsa:523 ATP6V1A; ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A (EC:3.6.3.14)

hsa04710 Circadian rhythm - mammal - Homo sapiens (human) (4)



cpd:C00575 3',5'-Cyclic AMP
hsa:9572 NR1D1; nuclear receptor subfamily 1, group D, member 1
hsa:8864 PER2; period homolog 2 (Drosophila)
hsa:8863 PER3; period homolog 3 (Drosophila)

hsa00062 Fatty acid elongation - Homo sapiens (human) (4)



cpd:C00249 Hexadecanoic acid
hsa:1892 ECHS1; enoyl CoA hydratase, short chain, 1, mitochondrial (EC:4.2.1.17)
hsa:3030 HADHA; hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit (EC:4.2.1.17 1.1.1.211)
hsa:5538 PPT1; palmitoyl-protein thioesterase 1 (EC:3.1.2.22)

hsa04975 Fat digestion and absorption - Homo sapiens (human) (4)



cpd:C00165 Diacylglycerol
hsa:19 ABCA1; ATP-binding cassette, sub-family A (ABC1), member 1
hsa:948 CD36; CD36 molecule (thrombospondin receptor)
hsa:5321 PLA2G4A; phospholipase A2, group IVA (cytosolic, calcium-dependent) (EC:3.1.1.5 3.1.1.4)

hsa00524 Butirosin and neomycin biosynthesis - Homo sapiens (human) (4)



cpd:C00031 D-Glucose
hsa:3098 HK1; hexokinase 1 (EC:2.7.1.1)
hsa:3099 HK2; hexokinase 2 (EC:2.7.1.1)
hsa:3101 HK3; hexokinase 3 (white cell) (EC:2.7.1.1)

hsa00531 Glycosaminoglycan degradation - Homo sapiens (human) (4)



hsa:411 ARSB; arylsulfatase B (EC:3.1.6.12)
hsa:2990 GUSB; glucuronidase, beta (EC:3.2.1.31)
hsa:3074 HEXB; hexosaminidase B (beta polypeptide) (EC:3.2.1.52)
hsa:10855 HPSE; heparanase

hsa04320 Dorso-ventral axis formation - Homo sapiens (human) (4)



hsa:2113 ETS1; v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)
hsa:5594 MAPK1; mitogen-activated protein kinase 1 (EC:2.7.11.24)
hsa:5595 MAPK3; mitogen-activated protein kinase 3 (EC:2.7.11.24)
hsa:4854 NOTCH3; notch 3

hsa00100 Steroid biosynthesis - Homo sapiens (human) (4)



cpd:C01673 Calcitriol
hsa:120227 CYP2R1; cytochrome P450, family 2, subfamily R, polypeptide 1 (EC:1.14.13.15)
hsa:6646 SOAT1; sterol O-acyltransferase 1 (EC:2.3.1.26)
hsa:7108 TM7SF2; transmembrane 7 superfamily member 2 (EC:1.3.1.70)

hsa00532 Glycosaminoglycan biosynthesis - chondroitin sulfate - Homo sapiens (human) (3)



hsa:50515 CHST11; carbohydrate (chondroitin 4) sulfotransferase 11 (EC:2.8.2.5)
hsa:29940 DSE; dermatan sulfate epimerase (EC:5.1.3.19)
hsa:64132 XYLT2; xylosyltransferase II (EC:2.4.2.26)

hsa04744 Phototransduction - Homo sapiens (human) (3)



cpd:C00238 Potassium cation
hsa:805 CALM2; calmodulin 2 (phosphorylase kinase, delta) (EC:2.7.11.19)
hsa:808 CALM3; calmodulin 3 (phosphorylase kinase, delta) (EC:2.7.11.19)

hsa00770 Pantothenate and CoA biosynthesis - Homo sapiens (human) (3)



hsa:80347 COASY; CoA synthase (EC:2.7.7.3 2.7.1.24)
hsa:1806 DPYD; dihydropyrimidine dehydrogenase (EC:1.3.1.2)
hsa:5167 ENPP1; ectonucleotide pyrophosphatase/phosphodiesterase 1 (EC:3.1.4.1 3.6.1.9)

hsa00563 Glycosylphosphatidylinositol(GPI)-anchor biosynthesis - Homo sapiens (human) (3)



cpd:C00350 Phosphatidylethanolamine
cpd:C01194 1-Phosphatidyl-D-myo-inositol
hsa:84720 PIGO; phosphatidylinositol glycan anchor biosynthesis, class O

hsa03022 Basal transcription factors - Homo sapiens (human) (3)



hsa:2957 GTF2A1; general transcription factor IIA, 1, 19/37kDa
hsa:6882 TAF11; TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa
hsa:9519 TBPL1; TBP-like 1

hsa00512 Mucin type O-Glycan biosynthesis - Homo sapiens (human) (3)



hsa:2591 GALNT3; UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3) (EC:2.4.1.41)
hsa:11226 GALNT6; UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 6 (GalNAc-T6) (EC:2.4.1.41)
hsa:51301 GCNT4; glucosaminyl (N-acetyl) transferase 4, core 2 (EC:2.4.1.102)

hsa03060 Protein export - Homo sapiens (human) (3)



hsa:3309 HSPA5; heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
hsa:9789 SPCS2; signal peptidase complex subunit 2 homolog (S. cerevisiae) (EC:3.4.-.-)
hsa:6726 SRP9; signal recognition particle 9kDa

hsa00040 Pentose and glucuronate interconversions - Homo sapiens (human) (3)



hsa:231 AKR1B1; aldo-keto reductase family 1, member B1 (aldose reductase) (EC:1.1.1.21)
hsa:219 ALDH1B1; aldehyde dehydrogenase 1 family, member B1 (EC:1.2.1.3)
hsa:2990 GUSB; glucuronidase, beta (EC:3.2.1.31)

hsa03460 Fanconi anemia pathway - Homo sapiens (human) (3)



hsa:2175 FANCA; Fanconi anemia, complementation group A
hsa:55215 FANCI; Fanconi anemia, complementation group I
hsa:11201 POLI; polymerase (DNA directed) iota (EC:2.7.7.7)

hsa00450 Selenocompound metabolism - Homo sapiens (human) (3)



hsa:883 CCBL1; cysteine conjugate-beta lyase, cytoplasmic (EC:2.6.1.64 2.6.1.7 4.4.1.13)
hsa:51091 SEPSECS; Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase (EC:2.9.1.2)
hsa:7296 TXNRD1; thioredoxin reductase 1 (EC:1.8.1.9)

hsa03015 mRNA surveillance pathway - Homo sapiens (human) (3)



hsa:55110 MAGOHB; mago-nashi homolog B (Drosophila)
hsa:8761 PABPC4; poly(A) binding protein, cytoplasmic 4 (inducible form)
hsa:23381 SMG5; smg-5 homolog, nonsense mediated mRNA decay factor (C. elegans)

hsa00053 Ascorbate and aldarate metabolism - Homo sapiens (human) (3)



hsa:219 ALDH1B1; aldehyde dehydrogenase 1 family, member B1 (EC:1.2.1.3)
hsa:501 ALDH7A1; aldehyde dehydrogenase 7 family, member A1 (EC:1.2.1.3 1.2.1.8 1.2.1.31)
hsa:223 ALDH9A1; aldehyde dehydrogenase 9 family, member A1 (EC:1.2.1.3 1.2.1.19 1.2.1.47)

hsa00471 D-Glutamine and D-glutamate metabolism - Homo sapiens (human) (3)



cpd:C00064 L-Glutamine
hsa:2744 GLS; glutaminase (EC:3.5.1.2)
hsa:27165 GLS2; glutaminase 2 (liver, mitochondrial) (EC:3.5.1.2)

hsa00750 Vitamin B6 metabolism - Homo sapiens (human) (2)



cpd:C00018 Pyridoxal phosphate
hsa:55163 PNPO; pyridoxamine 5'-phosphate oxidase (EC:1.4.3.5)

hsa00740 Riboflavin metabolism - Homo sapiens (human) (2)



hsa:645 BLVRB; biliverdin reductase B (flavin reductase (NADPH)) (EC:1.3.1.24 1.5.1.30)
hsa:5167 ENPP1; ectonucleotide pyrophosphatase/phosphodiesterase 1 (EC:3.1.4.1 3.6.1.9)

hsa00460 Cyanoamino acid metabolism - Homo sapiens (human) (2)



cpd:C00065 L-Serine
hsa:6470 SHMT1; serine hydroxymethyltransferase 1 (soluble) (EC:2.1.2.1)

hsa00534 Glycosaminoglycan biosynthesis - heparan sulfate - Homo sapiens (human) (2)



hsa:3340 NDST1; N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 (EC:2.8.2.8)
hsa:64132 XYLT2; xylosyltransferase II (EC:2.4.2.26)

hsa00472 D-Arginine and D-ornithine metabolism - Homo sapiens (human) (2)





cpd:C00062 L-Arginine
cpd:C00077 L-Ornithine

hsa05033 Nicotine addiction - Homo sapiens (human) (2)



hsa:2562 GABRB3; gamma-aminobutyric acid (GABA) A receptor, beta 3
hsa:2903 GRIN2A; glutamate receptor, ionotropic, N-methyl D-aspartate 2A

hsa00604 Glycosphingolipid biosynthesis - ganglio series - Homo sapiens (human) (2)



hsa:2583 B4GALNT1; beta-1,4-N-acetyl-galactosaminyl transferase 1 (EC:2.4.1.92)
hsa:3074 HEXB; hexosaminidase B (beta polypeptide) (EC:3.2.1.52)

hsa00790 Folate biosynthesis - Homo sapiens (human) (2)



cpd:C00504 Folate
hsa:2643 GCH1; GTP cyclohydrolase 1 (EC:3.5.4.16)

hsa03430 Mismatch repair - Homo sapiens (human) (2)



hsa:3978 LIG1; ligase I, DNA, ATP-dependent (EC:6.5.1.1)
hsa:5111 PCNA; proliferating cell nuclear antigen

hsa00514 Other types of O-glycan biosynthesis - Homo sapiens (human) (2)



hsa:29954 POMT2; protein-O-mannosyltransferase 2 (EC:2.4.1.109)
hsa:6480 ST6GAL1; ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 (EC:2.4.99.1)

hsa04130 SNARE interactions in vesicular transport - Homo sapiens (human) (2)



hsa:8676 STX11; syntaxin 11
hsa:55850 USE1; unconventional SNARE in the ER 1 homolog (S. cerevisiae)

hsa00232 Caffeine metabolism - Homo sapiens (human) (2)



cpd:C00385 Xanthine
hsa:7498 XDH; xanthine dehydrogenase (EC:1.17.1.4 1.17.3.2)

hsa00511 Other glycan degradation - Homo sapiens (human) (2)



hsa:64772 ENGASE; endo-beta-N-acetylglucosaminidase (EC:3.2.1.96)
hsa:3074 HEXB; hexosaminidase B (beta polypeptide) (EC:3.2.1.52)

hsa00920 Sulfur metabolism - Homo sapiens (human) (2)



cpd:C00065 L-Serine
hsa:50515 CHST11; carbohydrate (chondroitin 4) sulfotransferase 11 (EC:2.8.2.5)

hsa00603 Glycosphingolipid biosynthesis - globo series - Homo sapiens (human) (2)



hsa:3074 HEXB; hexosaminidase B (beta polypeptide) (EC:3.2.1.52)
hsa:4668 NAGA; N-acetylgalactosaminidase, alpha- (EC:3.2.1.49)

hsa04950 Maturity onset diabetes of the young - Homo sapiens (human) (2)



hsa:3630 INS; insulin
hsa:5080 PAX6; paired box 6

hsa00120 Primary bile acid biosynthesis - Homo sapiens (human) (2)



hsa:9023 CH25H; cholesterol 25-hydroxylase (EC:1.14.99.38)
hsa:9420 CYP7B1; cytochrome P450, family 7, subfamily B, polypeptide 1 (EC:1.14.13.100)

hsa04614 Renin-angiotensin system - Homo sapiens (human) (1)

hsa:4012 LNPEP; leucyl/cystinyl aminopeptidase (EC:3.4.11.3)

hsa00061 Fatty acid biosynthesis - Homo sapiens (human) (1)

cpd:C00249 Hexadecanoic acid

hsa04122 Sulfur relay system - Homo sapiens (human) (1)

hsa:55687 TRMU; tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase (EC:2.1.1.61)

hsa00430 Taurine and hypotaurine metabolism - Homo sapiens (human) (1)

hsa:51380 CSAD; cysteine sulfinic acid decarboxylase (EC:4.1.1.29)

hsa00785 Lipoic acid metabolism - Homo sapiens (human) (1)

cpd:C00725 Lipoate

hsa00400 Phenylalanine, tyrosine and tryptophan biosynthesis - Homo sapiens (human) (1)

cpd:C00078 L-Tryptophan

hsa00300 Lysine biosynthesis - Homo sapiens (human) (1)

hsa:501 ALDH7A1; aldehyde dehydrogenase 7 family, member A1 (EC:1.2.1.3 1.2.1.8 1.2.1.31)

hsa00130 Ubiquinone and other terpenoid-quinone biosynthesis - Homo sapiens (human) (1)

cpd:C02477 alpha-Tocopherol

hsa00601 Glycosphingolipid biosynthesis - lacto and neolacto series - Homo sapiens (human) (1)

gl:G00063 IV3NeuAc,III3Fuc-nLc4Cer

hsa00533 Glycosaminoglycan biosynthesis - keratan sulfate - Homo sapiens (human) (1)

hsa:10164 CHST4; carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4

hsa03440 Homologous recombination - Homo sapiens (human) (1)

hsa:5893 RAD52; RAD52 homolog (S. cerevisiae)

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