During its life cycle Herpes simplex (HSV-1) interacts with a number of host proteins and alters the expression of multiple messenger RNAs: This page links to a number of pages relevant to this host pathogen interactome .
- The HSV-1 host/pathogen interactome
- KEGG pathway analysis of the human genes/proteins of the interactome
Within this interactome there are numerous susceptibility genes for various diseases ( see index for the susceptibility gene dataset for each disease) . KEGG pathways were reanalysed for each overlapping dataset (i.e. genes common to the interactome and the disease in question).
There are a large number of human genes in the HSV-1/host interacome (1347) and 26846 genes in the human genome (at the time of writing): Any other dataset would be expected to contain 1347/26846 interactome genes (~ 5.1%). Similarly, for N susceptibility genes, N/26846 would be expected to appear in the HSV-1 interactome. All of these datasets, with the exception of ADHD were significantly enriched in HSV-1 related genes.
KEGG pathways for the susceptibility genes common to the HSV-1 interactome in :-
- ADHD: Attention deficit hyperactivity disorder:
- Autism:
- Alzheimer's disease
- Bipolar disorder
- Depression:
- Schizophrenia:
- Multiple sclerosis:
- Parkinson's disease
- Anorexia
- Childhood obesity:
- Chronic fatigue:
The pathways above consist of host genes common to the HSV-1/host interactome and the susceptibility gene datasets for each disease.
From Susceptibility genes are enriched in those of the herpes simplex (HSV-1) / host interactome in psychiatric and neurological disorders. Pathogens and disease 2013
