H.pylori PATHWAY

hsa01100 Metabolic pathways - Homo sapiens (human) (157)

cpd:C00005 NADPH cpd:C00006 NADP+ cpd:C00007 Oxygen cpd:C00011 CO2 cpd:C00014 Ammonia cpd:C00018 Pyridoxal phosphate cpd:C00025 L-Glutamate cpd:C00033 Acetate cpd:C00051 Glutathione cpd:C00062 L-Arginine cpd:C00064 L-Glutamine cpd:C00072 Ascorbate cpd:C00077 L-Ornithine cpd:C00078 L-Tryptophan cpd:C00080 H+ cpd:C00082 L-Tyrosine cpd:C00084 Acetaldehyde cpd:C00086 Urea cpd:C00155 L-Homocysteine cpd:C00179 Agmatine cpd:C00187 Cholesterol cpd:C00195 N-Acylsphingosine cpd:C00207 Acetone cpd:C00246 Butanoic acid cpd:C00280 Androstenedione cpd:C00315 Spermidine cpd:C00328 L-Kynurenine cpd:C00338 Lipopolysaccharide cpd:C00355 3,4-Dihydroxy-L-phenylalanine cpd:C00388 Histamine cpd:C00426 Dermatan sulfate cpd:C00468 Estrone cpd:C00473 Retinol cpd:C00550 Sphingomyelin cpd:C00584 Prostaglandin E2 cpd:C00750 Spermine cpd:C00903 Cinnamaldehyde cpd:C00925 Heparan sulfate cpd:C00951 Estradiol-17beta cpd:C01079 Protoporphyrinogen IX cpd:C01176 17alpha-Hydroxyprogesterone cpd:C01227 Dehydroepiandrosterone cpd:C01598 Melatonin cpd:C01953 Pregnenolone cpd:C02094 beta-Carotene cpd:C02165 Leukotriene B4 cpd:C02166 Leukotriene C4 cpd:C02477 alpha-Tocopherol cpd:C02737 Phosphatidylserine cpd:C03758 Dopamine cpd:C04598 2-Acetyl-1-alkyl-sn-glycero-3-phosphocholine ec:3.1.1.1 carboxylesterase; ali-esterase; B-esterase; monobutyrase; cocaine esterase; procaine esterase; methylbutyrase; vitamin A esterase; butyryl esterase; carboxyesterase; carboxylate esterase; carboxylic esterase; methylbutyrate esterase; triacetin esterase; carboxyl ester hydrolase; butyrate esterase; methylbutyrase; alpha-carboxylesterase; propionyl esterase; nonspecific carboxylesterase; esterase D; esterase B; esterase A; serine esterase; carboxylic acid esterase; cocaine esterase ec:3.1.1.32 phospholipase A1 hsa:28 ABO; ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase) (EC:2.4.1.37 2.4.1.40) hsa:10965 ACOT2; acyl-CoA thioesterase 2 (EC:3.1.2.2) hsa:8309 ACOX2; acyl-CoA oxidase 2, branched chain (EC:1.17.99.3) hsa:131 ADH7; alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide (EC:1.1.1.1) hsa:79814 AGMAT; agmatine ureohydrolase (agmatinase) (EC:3.5.3.11) hsa:210 ALAD; aminolevulinate dehydratase (EC:4.2.1.24) hsa:226 ALDOA; aldolase A, fructose-bisphosphate (EC:4.1.2.13) hsa:230 ALDOC; aldolase C, fructose-bisphosphate (EC:4.1.2.13) hsa:240 ALOX5; arachidonate 5-lipoxygenase (EC:1.13.11.34) hsa:23600 AMACR; alpha-methylacyl-CoA racemase (EC:5.1.99.4) hsa:262 AMD1; adenosylmethionine decarboxylase 1 (EC:4.1.1.50) hsa:383 ARG1; arginase 1 (EC:3.5.3.1) hsa:384 ARG2; arginase 2 (EC:3.5.3.1) hsa:440 ASNS; asparagine synthetase (glutamine-hydrolyzing) (EC:6.3.5.4) hsa:517 ATP5G2; ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9) hsa:9551 ATP5J2; ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F2 (EC:3.6.1.14) hsa:533 ATP6V0B; ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b (EC:3.6.3.14) hsa:525 ATP6V1B1; ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1 (EC:3.6.3.14) hsa:9296 ATP6V1F; ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F (EC:3.6.3.14) hsa:9550 ATP6V1G1; ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1 (EC:3.6.3.14) hsa:11041 B3GNT1; UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1 (EC:2.4.1.149) hsa:84002 B3GNT5; UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5 (EC:2.4.1.206) hsa:9331 B4GALT6; UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6 (EC:2.4.1.274) hsa:594 BCKDHB; branched chain keto acid dehydrogenase E1, beta polypeptide (EC:1.2.4.4) hsa:790 CAD; carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase (EC:2.1.3.2 3.5.2.3 6.3.5.5) hsa:10423 CDIPT; CDP-diacylglycerol--inositol 3-phosphatidyltransferase (EC:2.7.8.11) hsa:1119 CHKA; choline kinase alpha (EC:2.7.1.32 2.7.1.82) hsa:1152 CKB; creatine kinase, brain (EC:2.7.3.2) hsa:1312 COMT; catechol-O-methyltransferase (EC:2.1.1.6) hsa:4512 COX1; cytochrome c oxidase subunit I hsa:1544 CYP1A2; cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) hsa:1555 CYP2B6; cytochrome P450, family 2, subfamily B, polypeptide 6 (EC:1.14.14.1) hsa:1557 CYP2C19; cytochrome P450, family 2, subfamily C, polypeptide 19 (EC:1.14.13.48 1.14.13.49 1.14.13.80) hsa:1573 CYP2J2; cytochrome P450, family 2, subfamily J, polypeptide 2 (EC:1.14.14.1) hsa:51181 DCXR; dicarbonyl/L-xylulose reductase (EC:1.1.1.10) hsa:1644 DDC; dopa decarboxylase (aromatic L-amino acid decarboxylase) (EC:4.1.1.28) hsa:1716 DGUOK; deoxyguanosine kinase (EC:2.7.1.113) hsa:1738 DLD; dihydrolipoamide dehydrogenase (EC:1.8.1.4) hsa:1789 DNMT3B; DNA (cytosine-5-)-methyltransferase 3 beta (EC:2.1.1.37) hsa:2023 ENO1; enolase 1, (alpha) (EC:4.2.1.11) hsa:2027 ENO3; enolase 3 (beta, muscle) (EC:4.2.1.11) hsa:2271 FH; fumarate hydratase (EC:4.2.1.2) hsa:2524 FUT2; fucosyltransferase 2 (secretor status included) (EC:2.4.1.69) hsa:2525 FUT3; fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group) (EC:2.4.1.65) hsa:2526 FUT4; fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific) (EC:2.4.1.-) hsa:2529 FUT7; fucosyltransferase 7 (alpha (1,3) fucosyltransferase) (EC:2.4.1.-) hsa:2628 GATM; glycine amidinotransferase (L-arginine:glycine amidinotransferase) (EC:2.1.4.1) hsa:9945 GFPT2; glutamine-fructose-6-phosphate transaminase 2 (EC:2.6.1.16) hsa:2678 GGT1; gamma-glutamyltransferase 1 (EC:2.3.2.2 3.4.19.13 3.4.19.14) hsa:2821 GPI; glucose-6-phosphate isomerase (EC:5.3.1.9) hsa:3030 HADHA; hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit (EC:4.2.1.17 1.1.1.211) hsa:54363 HAO1; hydroxyacid oxidase (glycolate oxidase) 1 (EC:1.1.3.15) hsa:3067 HDC; histidine decarboxylase (EC:4.1.1.22) hsa:3074 HEXB; hexosaminidase B (beta polypeptide) (EC:3.2.1.52) hsa:3423 IDS; iduronate 2-sulfatase (EC:3.1.6.13) hsa:3615 IMPDH2; IMP (inosine 5'-monophosphate) dehydrogenase 2 (EC:1.1.1.205) hsa:3945 LDHB; lactate dehydrogenase B (EC:1.1.1.27) hsa:9388 LIPG; lipase, endothelial (EC:3.1.1.3) hsa:4128 MAOA; monoamine oxidase A (EC:1.4.3.4) hsa:4524 MTHFR; methylenetetrahydrofolate reductase (NAD(P)H) (EC:1.5.1.20) hsa:54187 NANS; N-acetylneuraminic acid synthase (EC:2.5.1.56 2.5.1.57) hsa:4697 NDUFA4; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4, 9kDa (EC:1.6.5.3 1.6.99.3) hsa:4725 NDUFS5; NADH dehydrogenase (ubiquinone) Fe-S protein 5, 15kDa (NADH-coenzyme Q reductase) hsa:4729 NDUFV2; NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa (EC:1.6.5.3 1.6.99.3) hsa:4842 NOS1; nitric oxide synthase 1 (neuronal) (EC:1.14.13.39) hsa:4843 NOS2; nitric oxide synthase 2, inducible (EC:1.14.13.39) hsa:50814 NSDHL; NAD(P) dependent steroid dehydrogenase-like (EC:1.1.1.170) hsa:4942 OAT; ornithine aminotransferase (EC:2.6.1.13) hsa:4953 ODC1; ornithine decarboxylase 1 (EC:4.1.1.17) hsa:5009 OTC; ornithine carbamoyltransferase (EC:2.1.3.3) hsa:5033 P4HA1; prolyl 4-hydroxylase, alpha polypeptide I (EC:1.14.11.2) hsa:5106 PCK2; phosphoenolpyruvate carboxykinase 2 (mitochondrial) (EC:4.1.1.32) hsa:9468 PCYT1B; phosphate cytidylyltransferase 1, choline, beta (EC:2.7.7.15) hsa:55276 PGM2; phosphoglucomutase 2 (EC:5.4.2.2 5.4.2.7) hsa:5277 PIGA; phosphatidylinositol glycan anchor biosynthesis, class A (EC:2.4.1.198) hsa:55650 PIGV; phosphatidylinositol glycan anchor biosynthesis, class V hsa:5287 PIK3C2B; phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta (EC:2.7.1.154) hsa:8395 PIP5K1B; phosphatidylinositol-4-phosphate 5-kinase, type I, beta (EC:2.7.1.68) hsa:5330 PLCB2; phospholipase C, beta 2 (EC:3.1.4.11) hsa:5332 PLCB4; phospholipase C, beta 4 (EC:3.1.4.11) hsa:51196 PLCE1; phospholipase C, epsilon 1 (EC:3.1.4.11) hsa:5335 PLCG1; phospholipase C, gamma 1 (EC:3.1.4.11) hsa:5337 PLD1; phospholipase D1, phosphatidylcholine-specific (EC:3.1.4.4) hsa:4860 PNP; purine nucleoside phosphorylase (EC:2.4.2.1) hsa:10621 POLR3F; polymerase (RNA) III (DNA directed) polypeptide F, 39 kDa hsa:8613 PPAP2B; phosphatidic acid phosphatase type 2B (EC:3.1.3.4) hsa:29968 PSAT1; phosphoserine aminotransferase 1 (EC:2.6.1.52) hsa:5723 PSPH; phosphoserine phosphatase (EC:3.1.3.3) hsa:5743 PTGS2; prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) hsa:23475 QPRT; quinolinate phosphoribosyltransferase (EC:2.4.2.19) hsa:6389 SDHA; succinate dehydrogenase complex, subunit A, flavoprotein (Fp) (EC:1.3.5.1) hsa:6390 SDHB; succinate dehydrogenase complex, subunit B, iron sulfur (Ip) (EC:1.3.5.1) hsa:6391 SDHC; succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa hsa:6392 SDHD; succinate dehydrogenase complex, subunit D, integral membrane protein hsa:9197 SLC33A1; solute carrier family 33 (acetyl-CoA transporter), member 1 hsa:6611 SMS; spermine synthase (EC:2.5.1.22) hsa:6480 ST6GAL1; ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 (EC:2.4.99.1) hsa:55808 ST6GALNAC1; ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 (EC:2.4.99.3) hsa:10312 TCIRG1; T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3 (EC:3.6.3.6) hsa:7167 TPI1; triosephosphate isomerase 1 (EC:5.3.1.1) hsa:7173 TPO; thyroid peroxidase (EC:1.11.1.8) hsa:54658 UGT1A1; UDP glucuronosyltransferase 1 family, polypeptide A1 (EC:2.4.1.17) hsa:7368 UGT8; UDP glycosyltransferase 8 (EC:2.4.1.45) hsa:7378 UPP1; uridine phosphorylase 1 (EC:2.4.2.3)

hsa05200 Pathways in cancer - Homo sapiens (human) (122)

cpd:C00187 Cholesterol cpd:C00280 Androstenedione cpd:C00951 Estradiol-17beta cpd:C01227 Dehydroepiandrosterone hsa:25 ABL1; c-abl oncogene 1, non-receptor tyrosine kinase (EC:2.7.10.2) hsa:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) hsa:324 APC; adenomatous polyposis coli hsa:572 BAD; BCL2-associated agonist of cell death hsa:581 BAX; BCL2-associated X protein hsa:596 BCL2; B-cell CLL/lymphoma 2 hsa:598 BCL2L1; BCL2-like 1 hsa:637 BID; BH3 interacting domain death agonist hsa:329 BIRC2; baculoviral IAP repeat containing 2 hsa:330 BIRC3; baculoviral IAP repeat containing 3 hsa:332 BIRC5; baculoviral IAP repeat containing 5 hsa:650 BMP2; bone morphogenetic protein 2 hsa:652 BMP4; bone morphogenetic protein 4 hsa:673 BRAF; v-raf murine sarcoma viral oncogene homolog B (EC:2.7.11.1) hsa:836 CASP3; caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) hsa:841 CASP8; caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) hsa:842 CASP9; caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) hsa:595 CCND1; cyclin D1 hsa:998 CDC42; cell division cycle 42 hsa:999 CDH1; cadherin 1, type 1, E-cadherin (epithelial) hsa:1019 CDK4; cyclin-dependent kinase 4 (EC:2.7.11.22) hsa:1026 CDKN1A; cyclin-dependent kinase inhibitor 1A (p21, Cip1) hsa:1027 CDKN1B; cyclin-dependent kinase inhibitor 1B (p27, Kip1) hsa:1029 CDKN2A; cyclin-dependent kinase inhibitor 2A hsa:1147 CHUK; conserved helix-loop-helix ubiquitous kinase (EC:2.7.11.10) hsa:1398 CRK; v-crk avian sarcoma virus CT10 oncogene homolog hsa:1399 CRKL; v-crk avian sarcoma virus CT10 oncogene homolog-like hsa:1441 CSF3R; colony stimulating factor 3 receptor (granulocyte) hsa:1499 CTNNB1; catenin (cadherin-associated protein), beta 1, 88kDa hsa:54205 CYCS; cytochrome c, somatic hsa:1856 DVL2; dishevelled segment polarity protein 2 hsa:1857 DVL3; dishevelled segment polarity protein 3 hsa:1869 E2F1; E2F transcription factor 1 hsa:1870 E2F2; E2F transcription factor 2 hsa:1950 EGF; epidermal growth factor hsa:1956 EGFR; epidermal growth factor receptor (EC:2.7.10.1) hsa:2064 ERBB2; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (EC:2.7.10.1) hsa:355 FAS; Fas cell surface death receptor hsa:2258 FGF13; fibroblast growth factor 13 hsa:2247 FGF2; fibroblast growth factor 2 (basic) hsa:26281 FGF20; fibroblast growth factor 20 hsa:2263 FGFR2; fibroblast growth factor receptor 2 (EC:2.7.10.1) hsa:2261 FGFR3; fibroblast growth factor receptor 3 (EC:2.7.10.1) hsa:2271 FH; fumarate hydratase (EC:4.2.1.2) hsa:2335 FN1; fibronectin 1 hsa:2353 FOS; FBJ murine osteosarcoma viral oncogene homolog hsa:2308 FOXO1; forkhead box O1 hsa:2735 GLI1; GLI family zinc finger 1 hsa:2736 GLI2; GLI family zinc finger 2 hsa:2885 GRB2; growth factor receptor-bound protein 2 hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26) hsa:2950 GSTP1; glutathione S-transferase pi 1 (EC:2.5.1.18) hsa:3091 HIF1A; hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) hsa:3320 HSP90AA1; heat shock protein 90kDa alpha (cytosolic), class A member 1 hsa:3326 HSP90AB1; heat shock protein 90kDa alpha (cytosolic), class B member 1 hsa:7184 HSP90B1; heat shock protein 90kDa beta (Grp94), member 1 hsa:3479 IGF1; insulin-like growth factor 1 (somatomedin C) hsa:3551 IKBKB; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta (EC:2.7.11.10) hsa:8517 IKBKG; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma hsa:3569 IL6; interleukin 6 (interferon, beta 2) hsa:3576 IL8; interleukin 8 hsa:3673 ITGA2; integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) hsa:3688 ITGB1; integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) hsa:3725 JUN; jun proto-oncogene hsa:354 KLK3; kallikrein-related peptidase 3 (EC:3.4.21.77) hsa:3845 KRAS; Kirsten rat sarcoma viral oncogene homolog hsa:284217 LAMA1; laminin, alpha 1 hsa:3912 LAMB1; laminin, beta 1 hsa:3915 LAMC1; laminin, gamma 1 (formerly LAMB2) hsa:51176 LEF1; lymphoid enhancer-binding factor 1 hsa:5604 MAP2K1; mitogen-activated protein kinase kinase 1 (EC:2.7.12.2) hsa:5594 MAPK1; mitogen-activated protein kinase 1 (EC:2.7.11.24) hsa:5595 MAPK3; mitogen-activated protein kinase 3 (EC:2.7.11.24) hsa:5599 MAPK8; mitogen-activated protein kinase 8 (EC:2.7.11.24) hsa:4193 MDM2; MDM2 oncogene, E3 ubiquitin protein ligase hsa:4233 MET; met proto-oncogene (EC:2.7.10.1) hsa:4292 MLH1; mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) hsa:4312 MMP1; matrix metallopeptidase 1 (interstitial collagenase) (EC:3.4.24.7) hsa:4318 MMP9; matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) hsa:4609 MYC; v-myc avian myelocytomatosis viral oncogene homolog hsa:4790 NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 hsa:4792 NFKBIA; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha hsa:4843 NOS2; nitric oxide synthase 2, inducible (EC:1.14.13.39) hsa:4893 NRAS; neuroblastoma RAS viral (v-ras) oncogene homolog hsa:5154 PDGFA; platelet-derived growth factor alpha polypeptide hsa:5155 PDGFB; platelet-derived growth factor beta polypeptide hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha) hsa:5335 PLCG1; phospholipase C, gamma 1 (EC:3.1.4.11) hsa:5337 PLD1; phospholipase D1, phosphatidylcholine-specific (EC:3.1.4.4) hsa:5467 PPARD; peroxisome proliferator-activated receptor delta hsa:5468 PPARG; peroxisome proliferator-activated receptor gamma hsa:5578 PRKCA; protein kinase C, alpha (EC:2.7.11.13) hsa:5728 PTEN; phosphatase and tensin homolog (EC:3.1.3.67 3.1.3.16 3.1.3.48) hsa:5743 PTGS2; prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) hsa:5747 PTK2; protein tyrosine kinase 2 (EC:2.7.10.2) hsa:5879 RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) hsa:5880 RAC2; ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) hsa:5894 RAF1; v-raf-1 murine leukemia viral oncogene homolog 1 (EC:2.7.11.1) hsa:5970 RELA; v-rel avian reticuloendotheliosis viral oncogene homolog A hsa:387 RHOA; ras homolog family member A hsa:6469 SHH; sonic hedgehog hsa:6502 SKP2; S-phase kinase-associated protein 2, E3 ubiquitin protein ligase hsa:6608 SMO; smoothened, frizzled family receptor hsa:6654 SOS1; son of sevenless homolog 1 (Drosophila) hsa:6772 STAT1; signal transducer and activator of transcription 1, 91kDa hsa:6774 STAT3; signal transducer and activator of transcription 3 (acute-phase response factor) hsa:6776 STAT5A; signal transducer and activator of transcription 5A hsa:6777 STAT5B; signal transducer and activator of transcription 5B hsa:6923 TCEB2; transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B) hsa:7039 TGFA; transforming growth factor, alpha hsa:7040 TGFB1; transforming growth factor, beta 1 hsa:7042 TGFB2; transforming growth factor, beta 2 hsa:7157 TP53; tumor protein p53 hsa:9618 TRAF4; TNF receptor-associated factor 4 hsa:7189 TRAF6; TNF receptor-associated factor 6, E3 ubiquitin protein ligase hsa:7422 VEGFA; vascular endothelial growth factor A hsa:7424 VEGFC; vascular endothelial growth factor C hsa:7472 WNT2; wingless-type MMTV integration site family member 2

hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human) (99)

cpd:C00533 Nitric oxide hsa:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) hsa:285 ANGPT2; angiopoietin 2 hsa:1386 ATF2; activating transcription factor 2 hsa:572 BAD; BCL2-associated agonist of cell death hsa:596 BCL2; B-cell CLL/lymphoma 2 hsa:598 BCL2L1; BCL2-like 1 hsa:672 BRCA1; breast cancer 1, early onset hsa:842 CASP9; caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) hsa:595 CCND1; cyclin D1 hsa:1019 CDK4; cyclin-dependent kinase 4 (EC:2.7.11.22) hsa:1026 CDKN1A; cyclin-dependent kinase inhibitor 1A (p21, Cip1) hsa:1027 CDKN1B; cyclin-dependent kinase inhibitor 1B (p27, Kip1) hsa:1129 CHRM2; cholinergic receptor, muscarinic 2 hsa:1147 CHUK; conserved helix-loop-helix ubiquitous kinase (EC:2.7.11.10) hsa:1385 CREB1; cAMP responsive element binding protein 1 hsa:9586 CREB5; cAMP responsive element binding protein 5 hsa:1441 CSF3R; colony stimulating factor 3 receptor (granulocyte) hsa:1945 EFNA4; ephrin-A4 hsa:1950 EGF; epidermal growth factor hsa:1956 EGFR; epidermal growth factor receptor (EC:2.7.10.1) hsa:2149 F2R; coagulation factor II (thrombin) receptor hsa:2258 FGF13; fibroblast growth factor 13 hsa:2247 FGF2; fibroblast growth factor 2 (basic) hsa:26281 FGF20; fibroblast growth factor 20 hsa:2263 FGFR2; fibroblast growth factor receptor 2 (EC:2.7.10.1) hsa:2261 FGFR3; fibroblast growth factor receptor 3 (EC:2.7.10.1) hsa:2324 FLT4; fms-related tyrosine kinase 4 (EC:2.7.10.1) hsa:2335 FN1; fibronectin 1 hsa:2783 GNB2; guanine nucleotide binding protein (G protein), beta polypeptide 2 hsa:2885 GRB2; growth factor receptor-bound protein 2 hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26) hsa:3320 HSP90AA1; heat shock protein 90kDa alpha (cytosolic), class A member 1 hsa:3326 HSP90AB1; heat shock protein 90kDa alpha (cytosolic), class B member 1 hsa:7184 HSP90B1; heat shock protein 90kDa beta (Grp94), member 1 hsa:3439 IFNA1; interferon, alpha 1 hsa:3445 IFNA8; interferon, alpha 8 hsa:3454 IFNAR1; interferon (alpha, beta and omega) receptor 1 hsa:3455 IFNAR2; interferon (alpha, beta and omega) receptor 2 hsa:3479 IGF1; insulin-like growth factor 1 (somatomedin C) hsa:3551 IKBKB; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta (EC:2.7.11.10) hsa:8517 IKBKG; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma hsa:3558 IL2; interleukin 2 hsa:3559 IL2RA; interleukin 2 receptor, alpha hsa:3560 IL2RB; interleukin 2 receptor, beta hsa:3561 IL2RG; interleukin 2 receptor, gamma hsa:3562 IL3; interleukin 3 (colony-stimulating factor, multiple) hsa:3563 IL3RA; interleukin 3 receptor, alpha (low affinity) hsa:3565 IL4; interleukin 4 hsa:3566 IL4R; interleukin 4 receptor hsa:3569 IL6; interleukin 6 (interferon, beta 2) hsa:3574 IL7; interleukin 7 hsa:3575 IL7R; interleukin 7 receptor hsa:3667 IRS1; insulin receptor substrate 1 hsa:3673 ITGA2; integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) hsa:3678 ITGA5; integrin, alpha 5 (fibronectin receptor, alpha polypeptide) hsa:3688 ITGB1; integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) hsa:3691 ITGB4; integrin, beta 4 hsa:3717 JAK2; Janus kinase 2 (EC:2.7.10.2) hsa:3718 JAK3; Janus kinase 3 (EC:2.7.10.2) hsa:3845 KRAS; Kirsten rat sarcoma viral oncogene homolog hsa:284217 LAMA1; laminin, alpha 1 hsa:3912 LAMB1; laminin, beta 1 hsa:3915 LAMC1; laminin, gamma 1 (formerly LAMB2) hsa:5604 MAP2K1; mitogen-activated protein kinase kinase 1 (EC:2.7.12.2) hsa:5594 MAPK1; mitogen-activated protein kinase 1 (EC:2.7.11.24) hsa:5595 MAPK3; mitogen-activated protein kinase 3 (EC:2.7.11.24) hsa:4170 MCL1; myeloid cell leukemia sequence 1 (BCL2-related) hsa:4193 MDM2; MDM2 oncogene, E3 ubiquitin protein ligase hsa:4233 MET; met proto-oncogene (EC:2.7.10.1) hsa:4609 MYC; v-myc avian myelocytomatosis viral oncogene homolog hsa:4790 NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 hsa:4893 NRAS; neuroblastoma RAS viral (v-ras) oncogene homolog hsa:5008 OSM; oncostatin M hsa:9180 OSMR; oncostatin M receptor hsa:5106 PCK2; phosphoenolpyruvate carboxykinase 2 (mitochondrial) (EC:4.1.1.32) hsa:5154 PDGFA; platelet-derived growth factor alpha polypeptide hsa:5155 PDGFB; platelet-derived growth factor beta polypeptide hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha) hsa:5578 PRKCA; protein kinase C, alpha (EC:2.7.11.13) hsa:5590 PRKCZ; protein kinase C, zeta (EC:2.7.11.13) hsa:5728 PTEN; phosphatase and tensin homolog (EC:3.1.3.67 3.1.3.16 3.1.3.48) hsa:5747 PTK2; protein tyrosine kinase 2 (EC:2.7.10.2) hsa:5879 RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) hsa:5894 RAF1; v-raf-1 murine leukemia viral oncogene homolog 1 (EC:2.7.11.1) hsa:5934 RBL2; retinoblastoma-like 2 (p130) hsa:5970 RELA; v-rel avian reticuloendotheliosis viral oncogene homolog A hsa:6654 SOS1; son of sevenless homolog 1 (Drosophila) hsa:6850 SYK; spleen tyrosine kinase (EC:2.7.10.2) hsa:7057 THBS1; thrombospondin 1 hsa:7097 TLR2; toll-like receptor 2 hsa:7099 TLR4; toll-like receptor 4 hsa:7157 TP53; tumor protein p53 hsa:7422 VEGFA; vascular endothelial growth factor A hsa:7424 VEGFC; vascular endothelial growth factor C hsa:7448 VTN; vitronectin hsa:7450 VWF; von Willebrand factor hsa:7529 YWHAB; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide hsa:10971 YWHAQ; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide

hsa04060 Cytokine-cytokine receptor interaction - Homo sapiens (human) (83)

hsa:90 ACVR1; activin A receptor, type I (EC:2.7.11.30) hsa:650 BMP2; bone morphogenetic protein 2 hsa:655 BMP7; bone morphogenetic protein 7 hsa:6362 CCL18; chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) hsa:6363 CCL19; chemokine (C-C motif) ligand 19 hsa:6347 CCL2; chemokine (C-C motif) ligand 2 hsa:6364 CCL20; chemokine (C-C motif) ligand 20 hsa:6348 CCL3; chemokine (C-C motif) ligand 3 hsa:6351 CCL4; chemokine (C-C motif) ligand 4 hsa:6352 CCL5; chemokine (C-C motif) ligand 5 hsa:6354 CCL7; chemokine (C-C motif) ligand 7 hsa:1437 CSF2; colony stimulating factor 2 (granulocyte-macrophage) hsa:1439 CSF2RB; colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) hsa:1441 CSF3R; colony stimulating factor 3 receptor (granulocyte) hsa:2919 CXCL1; chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) hsa:3627 CXCL10; chemokine (C-X-C motif) ligand 10 hsa:6373 CXCL11; chemokine (C-X-C motif) ligand 11 hsa:10563 CXCL13; chemokine (C-X-C motif) ligand 13 hsa:2920 CXCL2; chemokine (C-X-C motif) ligand 2 hsa:2921 CXCL3; chemokine (C-X-C motif) ligand 3 hsa:6374 CXCL5; chemokine (C-X-C motif) ligand 5 hsa:4283 CXCL9; chemokine (C-X-C motif) ligand 9 hsa:3579 CXCR2; chemokine (C-X-C motif) receptor 2 hsa:7852 CXCR4; chemokine (C-X-C motif) receptor 4 hsa:1950 EGF; epidermal growth factor hsa:1956 EGFR; epidermal growth factor receptor (EC:2.7.10.1) hsa:355 FAS; Fas cell surface death receptor hsa:2324 FLT4; fms-related tyrosine kinase 4 (EC:2.7.10.1) hsa:8200 GDF5; growth differentiation factor 5 hsa:3439 IFNA1; interferon, alpha 1 hsa:3445 IFNA8; interferon, alpha 8 hsa:3454 IFNAR1; interferon (alpha, beta and omega) receptor 1 hsa:3455 IFNAR2; interferon (alpha, beta and omega) receptor 2 hsa:3458 IFNG; interferon, gamma hsa:3459 IFNGR1; interferon gamma receptor 1 hsa:3586 IL10; interleukin 10 hsa:3587 IL10RA; interleukin 10 receptor, alpha hsa:3589 IL11; interleukin 11 hsa:3596 IL13; interleukin 13 hsa:3605 IL17A; interleukin 17A hsa:8807 IL18RAP; interleukin 18 receptor accessory protein hsa:3552 IL1A; interleukin 1, alpha hsa:3553 IL1B; interleukin 1, beta hsa:3554 IL1R1; interleukin 1 receptor, type I hsa:7850 IL1R2; interleukin 1 receptor, type II hsa:3558 IL2; interleukin 2 hsa:51561 IL23A; interleukin 23, alpha subunit p19 hsa:3559 IL2RA; interleukin 2 receptor, alpha hsa:3560 IL2RB; interleukin 2 receptor, beta hsa:3561 IL2RG; interleukin 2 receptor, gamma hsa:3562 IL3; interleukin 3 (colony-stimulating factor, multiple) hsa:3563 IL3RA; interleukin 3 receptor, alpha (low affinity) hsa:3565 IL4; interleukin 4 hsa:3566 IL4R; interleukin 4 receptor hsa:3569 IL6; interleukin 6 (interferon, beta 2) hsa:3572 IL6ST; interleukin 6 signal transducer (gp130, oncostatin M receptor) hsa:3574 IL7; interleukin 7 hsa:3575 IL7R; interleukin 7 receptor hsa:3576 IL8; interleukin 8 hsa:3581 IL9R; interleukin 9 receptor hsa:3624 INHBA; inhibin, beta A hsa:83729 INHBE; inhibin, beta E hsa:3952 LEP; leptin hsa:3976 LIF; leukemia inhibitory factor hsa:4233 MET; met proto-oncogene (EC:2.7.10.1) hsa:5008 OSM; oncostatin M hsa:9180 OSMR; oncostatin M receptor hsa:5154 PDGFA; platelet-derived growth factor alpha polypeptide hsa:5155 PDGFB; platelet-derived growth factor beta polypeptide hsa:7040 TGFB1; transforming growth factor, beta 1 hsa:7042 TGFB2; transforming growth factor, beta 2 hsa:7124 TNF; tumor necrosis factor hsa:7132 TNFRSF1A; tumor necrosis factor receptor superfamily, member 1A hsa:7133 TNFRSF1B; tumor necrosis factor receptor superfamily, member 1B hsa:7293 TNFRSF4; tumor necrosis factor receptor superfamily, member 4 hsa:3604 TNFRSF9; tumor necrosis factor receptor superfamily, member 9 hsa:8600 TNFSF11; tumor necrosis factor (ligand) superfamily, member 11 hsa:8741 TNFSF13; tumor necrosis factor (ligand) superfamily, member 13 hsa:10673 TNFSF13B; tumor necrosis factor (ligand) superfamily, member 13b hsa:7173 TPO; thyroid peroxidase (EC:1.11.1.8) hsa:85480 TSLP; thymic stromal lymphopoietin hsa:7422 VEGFA; vascular endothelial growth factor A hsa:7424 VEGFC; vascular endothelial growth factor C

hsa05166 HTLV-I infection - Homo sapiens (human) (83)

cpd:C00027 Hydrogen peroxide hsa:115 ADCY9; adenylate cyclase 9 (EC:4.6.1.1) hsa:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) hsa:324 APC; adenomatous polyposis coli hsa:1386 ATF2; activating transcription factor 2 hsa:467 ATF3; activating transcription factor 3 hsa:472 ATM; ataxia telangiectasia mutated (EC:2.7.11.1) hsa:581 BAX; BCL2-associated X protein hsa:598 BCL2L1; BCL2-like 1 hsa:9184 BUB3; BUB3 mitotic checkpoint protein hsa:595 CCND1; cyclin D1 hsa:915 CD3D; CD3d molecule, delta (CD3-TCR complex) hsa:1019 CDK4; cyclin-dependent kinase 4 (EC:2.7.11.22) hsa:1026 CDKN1A; cyclin-dependent kinase inhibitor 1A (p21, Cip1) hsa:1029 CDKN2A; cyclin-dependent kinase inhibitor 2A hsa:1147 CHUK; conserved helix-loop-helix ubiquitous kinase (EC:2.7.11.10) hsa:1385 CREB1; cAMP responsive element binding protein 1 hsa:1437 CSF2; colony stimulating factor 2 (granulocyte-macrophage) hsa:1499 CTNNB1; catenin (cadherin-associated protein), beta 1, 88kDa hsa:1856 DVL2; dishevelled segment polarity protein 2 hsa:1857 DVL3; dishevelled segment polarity protein 3 hsa:1869 E2F1; E2F transcription factor 1 hsa:1870 E2F2; E2F transcription factor 2 hsa:1958 EGR1; early growth response 1 hsa:1959 EGR2; early growth response 2 hsa:2002 ELK1; ELK1, member of ETS oncogene family hsa:2114 ETS2; v-ets avian erythroblastosis virus E26 oncogene homolog 2 hsa:2353 FOS; FBJ murine osteosarcoma viral oncogene homolog hsa:8061 FOSL1; FOS-like antigen 1 hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26) hsa:3106 HLA-B; major histocompatibility complex, class I, B hsa:3108 HLA-DMA; major histocompatibility complex, class II, DM alpha hsa:3117 HLA-DQA1; major histocompatibility complex, class II, DQ alpha 1 hsa:3119 HLA-DQB1; major histocompatibility complex, class II, DQ beta 1 hsa:3122 HLA-DRA; major histocompatibility complex, class II, DR alpha hsa:3125 HLA-DRB3; major histocompatibility complex, class II, DR beta 3 hsa:3127 HLA-DRB5; major histocompatibility complex, class II, DR beta 5 hsa:3134 HLA-F; major histocompatibility complex, class I, F hsa:3383 ICAM1; intercellular adhesion molecule 1 hsa:3551 IKBKB; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta (EC:2.7.11.10) hsa:8517 IKBKG; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma hsa:3554 IL1R1; interleukin 1 receptor, type I hsa:7850 IL1R2; interleukin 1 receptor, type II hsa:3558 IL2; interleukin 2 hsa:3559 IL2RA; interleukin 2 receptor, alpha hsa:3560 IL2RB; interleukin 2 receptor, beta hsa:3561 IL2RG; interleukin 2 receptor, gamma hsa:3569 IL6; interleukin 6 (interferon, beta 2) hsa:3683 ITGAL; integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) hsa:3689 ITGB2; integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) hsa:3718 JAK3; Janus kinase 3 (EC:2.7.10.2) hsa:3725 JUN; jun proto-oncogene hsa:3845 KRAS; Kirsten rat sarcoma viral oncogene homolog hsa:3932 LCK; lymphocyte-specific protein tyrosine kinase (EC:2.7.10.2) hsa:6416 MAP2K4; mitogen-activated protein kinase kinase 4 (EC:2.7.12.2) hsa:4214 MAP3K1; mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase (EC:2.7.11.25) hsa:9020 MAP3K14; mitogen-activated protein kinase kinase kinase 14 (EC:2.7.11.25) hsa:5599 MAPK8; mitogen-activated protein kinase 8 (EC:2.7.11.24) hsa:4609 MYC; v-myc avian myelocytomatosis viral oncogene homolog hsa:4776 NFATC4; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 hsa:4790 NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 hsa:4792 NFKBIA; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha hsa:4893 NRAS; neuroblastoma RAS viral (v-ras) oncogene homolog hsa:5111 PCNA; proliferating cell nuclear antigen hsa:5154 PDGFA; platelet-derived growth factor alpha polypeptide hsa:5155 PDGFB; platelet-derived growth factor beta polypeptide hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha) hsa:5530 PPP3CA; protein phosphatase 3, catalytic subunit, alpha isozyme (EC:3.1.3.16) hsa:5970 RELA; v-rel avian reticuloendotheliosis viral oncogene homolog A hsa:6237 RRAS; related RAS viral (r-ras) oncogene homolog hsa:22800 RRAS2; related RAS viral (r-ras) oncogene homolog 2 hsa:6722 SRF; serum response factor (c-fos serum response element-binding transcription factor) hsa:6776 STAT5A; signal transducer and activator of transcription 5A hsa:6777 STAT5B; signal transducer and activator of transcription 5B hsa:7040 TGFB1; transforming growth factor, beta 1 hsa:7042 TGFB2; transforming growth factor, beta 2 hsa:7094 TLN1; talin 1 hsa:7124 TNF; tumor necrosis factor hsa:7132 TNFRSF1A; tumor necrosis factor receptor superfamily, member 1A hsa:7157 TP53; tumor protein p53 hsa:7412 VCAM1; vascular cell adhesion molecule 1 hsa:7472 WNT2; wingless-type MMTV integration site family member 2 hsa:7494 XBP1; X-box binding protein 1

hsa04010 MAPK signaling pathway - Homo sapiens (human) (78)

cpd:C00338 Lipopolysaccharide hsa:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) hsa:408 ARRB1; arrestin, beta 1 hsa:1386 ATF2; activating transcription factor 2 hsa:673 BRAF; v-raf murine sarcoma viral oncogene homolog B (EC:2.7.11.1) hsa:836 CASP3; caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) hsa:929 CD14; CD14 molecule hsa:998 CDC42; cell division cycle 42 hsa:1147 CHUK; conserved helix-loop-helix ubiquitous kinase (EC:2.7.11.10) hsa:1398 CRK; v-crk avian sarcoma virus CT10 oncogene homolog hsa:1399 CRKL; v-crk avian sarcoma virus CT10 oncogene homolog-like hsa:1649 DDIT3; DNA-damage-inducible transcript 3 hsa:1843 DUSP1; dual specificity phosphatase 1 (EC:3.1.3.16 3.1.3.48) hsa:11221 DUSP10; dual specificity phosphatase 10 (EC:3.1.3.16 3.1.3.48) hsa:1846 DUSP4; dual specificity phosphatase 4 (EC:3.1.3.16 3.1.3.48) hsa:1848 DUSP6; dual specificity phosphatase 6 (EC:3.1.3.16 3.1.3.48) hsa:1950 EGF; epidermal growth factor hsa:1956 EGFR; epidermal growth factor receptor (EC:2.7.10.1) hsa:2002 ELK1; ELK1, member of ETS oncogene family hsa:355 FAS; Fas cell surface death receptor hsa:2258 FGF13; fibroblast growth factor 13 hsa:2247 FGF2; fibroblast growth factor 2 (basic) hsa:26281 FGF20; fibroblast growth factor 20 hsa:2263 FGFR2; fibroblast growth factor receptor 2 (EC:2.7.10.1) hsa:2261 FGFR3; fibroblast growth factor receptor 3 (EC:2.7.10.1) hsa:2353 FOS; FBJ murine osteosarcoma viral oncogene homolog hsa:1647 GADD45A; growth arrest and DNA-damage-inducible, alpha hsa:2885 GRB2; growth factor receptor-bound protein 2 hsa:3312 HSPA8; heat shock 70kDa protein 8 hsa:3551 IKBKB; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta (EC:2.7.11.10) hsa:8517 IKBKG; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma hsa:3552 IL1A; interleukin 1, alpha hsa:3553 IL1B; interleukin 1, beta hsa:3554 IL1R1; interleukin 1 receptor, type I hsa:7850 IL1R2; interleukin 1 receptor, type II hsa:3725 JUN; jun proto-oncogene hsa:3727 JUND; jun D proto-oncogene hsa:3845 KRAS; Kirsten rat sarcoma viral oncogene homolog hsa:5604 MAP2K1; mitogen-activated protein kinase kinase 1 (EC:2.7.12.2) hsa:5606 MAP2K3; mitogen-activated protein kinase kinase 3 (EC:2.7.12.2) hsa:6416 MAP2K4; mitogen-activated protein kinase kinase 4 (EC:2.7.12.2) hsa:4214 MAP3K1; mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase (EC:2.7.11.25) hsa:9020 MAP3K14; mitogen-activated protein kinase kinase kinase 14 (EC:2.7.11.25) hsa:10746 MAP3K2; mitogen-activated protein kinase kinase kinase 2 (EC:2.7.11.25) hsa:6885 MAP3K7; mitogen-activated protein kinase kinase kinase 7 (EC:2.7.11.25) hsa:5594 MAPK1; mitogen-activated protein kinase 1 (EC:2.7.11.24) hsa:1432 MAPK14; mitogen-activated protein kinase 14 (EC:2.7.11.24) hsa:5595 MAPK3; mitogen-activated protein kinase 3 (EC:2.7.11.24) hsa:5599 MAPK8; mitogen-activated protein kinase 8 (EC:2.7.11.24) hsa:23162 MAPK8IP3; mitogen-activated protein kinase 8 interacting protein 3 hsa:4137 MAPT; microtubule-associated protein tau hsa:4609 MYC; v-myc avian myelocytomatosis viral oncogene homolog hsa:4790 NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 hsa:4893 NRAS; neuroblastoma RAS viral (v-ras) oncogene homolog hsa:5058 PAK1; p21 protein (Cdc42/Rac)-activated kinase 1 (EC:2.7.11.1) hsa:5062 PAK2; p21 protein (Cdc42/Rac)-activated kinase 2 (EC:2.7.11.1) hsa:5154 PDGFA; platelet-derived growth factor alpha polypeptide hsa:5155 PDGFB; platelet-derived growth factor beta polypeptide hsa:5530 PPP3CA; protein phosphatase 3, catalytic subunit, alpha isozyme (EC:3.1.3.16) hsa:5578 PRKCA; protein kinase C, alpha (EC:2.7.11.13) hsa:5778 PTPN7; protein tyrosine phosphatase, non-receptor type 7 (EC:3.1.3.48) hsa:5879 RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) hsa:5880 RAC2; ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) hsa:5894 RAF1; v-raf-1 murine leukemia viral oncogene homolog 1 (EC:2.7.11.1) hsa:5906 RAP1A; RAP1A, member of RAS oncogene family hsa:5921 RASA1; RAS p21 protein activator (GTPase activating protein) 1 hsa:5970 RELA; v-rel avian reticuloendotheliosis viral oncogene homolog A hsa:9252 RPS6KA5; ribosomal protein S6 kinase, 90kDa, polypeptide 5 (EC:2.7.11.1) hsa:6237 RRAS; related RAS viral (r-ras) oncogene homolog hsa:22800 RRAS2; related RAS viral (r-ras) oncogene homolog 2 hsa:6654 SOS1; son of sevenless homolog 1 (Drosophila) hsa:6722 SRF; serum response factor (c-fos serum response element-binding transcription factor) hsa:7040 TGFB1; transforming growth factor, beta 1 hsa:7042 TGFB2; transforming growth factor, beta 2 hsa:7124 TNF; tumor necrosis factor hsa:7132 TNFRSF1A; tumor necrosis factor receptor superfamily, member 1A hsa:7157 TP53; tumor protein p53 hsa:7189 TRAF6; TNF receptor-associated factor 6, E3 ubiquitin protein ligase

hsa05205 Proteoglycans in cancer - Homo sapiens (human) (74)

cpd:C00426 Dermatan sulfate cpd:C00607 Chondroitin sulfate cpd:C00925 Heparan sulfate hsa:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) hsa:673 BRAF; v-raf murine sarcoma viral oncogene homolog B (EC:2.7.11.1) hsa:836 CASP3; caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) hsa:857 CAV1; caveolin 1, caveolae protein, 22kDa hsa:595 CCND1; cyclin D1 hsa:960 CD44; CD44 molecule (Indian blood group) hsa:998 CDC42; cell division cycle 42 hsa:1026 CDKN1A; cyclin-dependent kinase inhibitor 1A (p21, Cip1) hsa:1499 CTNNB1; catenin (cadherin-associated protein), beta 1, 88kDa hsa:2017 CTTN; cortactin hsa:1956 EGFR; epidermal growth factor receptor (EC:2.7.10.1) hsa:2002 ELK1; ELK1, member of ETS oncogene family hsa:2064 ERBB2; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (EC:2.7.10.1) hsa:7430 EZR; ezrin hsa:355 FAS; Fas cell surface death receptor hsa:2258 FGF13; fibroblast growth factor 13 hsa:2247 FGF2; fibroblast growth factor 2 (basic) hsa:26281 FGF20; fibroblast growth factor 20 hsa:2335 FN1; fibronectin 1 hsa:2549 GAB1; GRB2-associated binding protein 1 hsa:2885 GRB2; growth factor receptor-bound protein 2 hsa:1839 HBEGF; heparin-binding EGF-like growth factor hsa:3091 HIF1A; hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) hsa:3236 HOXD10; homeobox D10 hsa:3479 IGF1; insulin-like growth factor 1 (somatomedin C) hsa:3481 IGF2; insulin-like growth factor 2 (somatomedin A) hsa:3673 ITGA2; integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) hsa:3678 ITGA5; integrin, alpha 5 (fibronectin receptor, alpha polypeptide) hsa:3688 ITGB1; integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) hsa:3709 ITPR2; inositol 1,4,5-trisphosphate receptor, type 2 hsa:3845 KRAS; Kirsten rat sarcoma viral oncogene homolog hsa:5604 MAP2K1; mitogen-activated protein kinase kinase 1 (EC:2.7.12.2) hsa:5594 MAPK1; mitogen-activated protein kinase 1 (EC:2.7.11.24) hsa:1432 MAPK14; mitogen-activated protein kinase 14 (EC:2.7.11.24) hsa:5595 MAPK3; mitogen-activated protein kinase 3 (EC:2.7.11.24) hsa:4193 MDM2; MDM2 oncogene, E3 ubiquitin protein ligase hsa:4233 MET; met proto-oncogene (EC:2.7.10.1) hsa:4318 MMP9; matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) hsa:4478 MSN; moesin hsa:4609 MYC; v-myc avian myelocytomatosis viral oncogene homolog hsa:4893 NRAS; neuroblastoma RAS viral (v-ras) oncogene homolog hsa:5058 PAK1; p21 protein (Cdc42/Rac)-activated kinase 1 (EC:2.7.11.1) hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha) hsa:5328 PLAU; plasminogen activator, urokinase (EC:3.4.21.73) hsa:51196 PLCE1; phospholipase C, epsilon 1 (EC:3.1.4.11) hsa:5335 PLCG1; phospholipase C, gamma 1 (EC:3.1.4.11) hsa:5578 PRKCA; protein kinase C, alpha (EC:2.7.11.13) hsa:5747 PTK2; protein tyrosine kinase 2 (EC:2.7.10.2) hsa:5781 PTPN11; protein tyrosine phosphatase, non-receptor type 11 (EC:3.1.3.48) hsa:5777 PTPN6; protein tyrosine phosphatase, non-receptor type 6 (EC:3.1.3.48) hsa:5829 PXN; paxillin hsa:5879 RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) hsa:5894 RAF1; v-raf-1 murine leukemia viral oncogene homolog 1 (EC:2.7.11.1) hsa:387 RHOA; ras homolog family member A hsa:6237 RRAS; related RAS viral (r-ras) oncogene homolog hsa:22800 RRAS2; related RAS viral (r-ras) oncogene homolog 2 hsa:6385 SDC4; syndecan 4 hsa:6608 SMO; smoothened, frizzled family receptor hsa:6654 SOS1; son of sevenless homolog 1 (Drosophila) hsa:6714 SRC; v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (EC:2.7.10.2) hsa:6774 STAT3; signal transducer and activator of transcription 3 (acute-phase response factor) hsa:7040 TGFB1; transforming growth factor, beta 1 hsa:7042 TGFB2; transforming growth factor, beta 2 hsa:7057 THBS1; thrombospondin 1 hsa:7097 TLR2; toll-like receptor 2 hsa:7099 TLR4; toll-like receptor 4 hsa:7124 TNF; tumor necrosis factor hsa:7157 TP53; tumor protein p53 hsa:7422 VEGFA; vascular endothelial growth factor A hsa:7448 VTN; vitronectin hsa:7472 WNT2; wingless-type MMTV integration site family member 2

hsa05152 Tuberculosis - Homo sapiens (human) (71)

cpd:C00338 Lipopolysaccharide hsa:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) hsa:533 ATP6V0B; ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b (EC:3.6.3.14) hsa:572 BAD; BCL2-associated agonist of cell death hsa:581 BAX; BCL2-associated X protein hsa:596 BCL2; B-cell CLL/lymphoma 2 hsa:637 BID; BH3 interacting domain death agonist hsa:718 C3; complement component 3 (EC:3.4.21.43) hsa:820 CAMP; cathelicidin antimicrobial peptide hsa:836 CASP3; caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) hsa:841 CASP8; caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) hsa:842 CASP9; caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) hsa:929 CD14; CD14 molecule hsa:30835 CD209; CD209 molecule hsa:972 CD74; CD74 molecule, major histocompatibility complex, class II invariant chain hsa:4261 CIITA; class II, major histocompatibility complex, transactivator hsa:1378 CR1; complement component (3b/4b) receptor 1 (Knops blood group) hsa:1385 CREB1; cAMP responsive element binding protein 1 hsa:1509 CTSD; cathepsin D (EC:3.4.23.5) hsa:54205 CYCS; cytochrome c, somatic hsa:3108 HLA-DMA; major histocompatibility complex, class II, DM alpha hsa:3117 HLA-DQA1; major histocompatibility complex, class II, DQ alpha 1 hsa:3119 HLA-DQB1; major histocompatibility complex, class II, DQ beta 1 hsa:3122 HLA-DRA; major histocompatibility complex, class II, DR alpha hsa:3125 HLA-DRB3; major histocompatibility complex, class II, DR beta 3 hsa:3127 HLA-DRB5; major histocompatibility complex, class II, DR beta 5 hsa:3329 HSPD1; heat shock 60kDa protein 1 (chaperonin) hsa:3439 IFNA1; interferon, alpha 1 hsa:3445 IFNA8; interferon, alpha 8 hsa:3458 IFNG; interferon, gamma hsa:3459 IFNGR1; interferon gamma receptor 1 hsa:3586 IL10; interleukin 10 hsa:3587 IL10RA; interleukin 10 receptor, alpha hsa:3552 IL1A; interleukin 1, alpha hsa:3553 IL1B; interleukin 1, beta hsa:51561 IL23A; interleukin 23, alpha subunit p19 hsa:3569 IL6; interleukin 6 (interferon, beta 2) hsa:3654 IRAK1; interleukin-1 receptor-associated kinase 1 (EC:2.7.11.1) hsa:3684 ITGAM; integrin, alpha M (complement component 3 receptor 3 subunit) hsa:3687 ITGAX; integrin, alpha X (complement component 3 receptor 4 subunit) hsa:3689 ITGB2; integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) hsa:3717 JAK2; Janus kinase 2 (EC:2.7.10.2) hsa:3916 LAMP1; lysosomal-associated membrane protein 1 hsa:3920 LAMP2; lysosomal-associated membrane protein 2 hsa:3929 LBP; lipopolysaccharide binding protein hsa:5594 MAPK1; mitogen-activated protein kinase 1 (EC:2.7.11.24) hsa:1432 MAPK14; mitogen-activated protein kinase 14 (EC:2.7.11.24) hsa:5595 MAPK3; mitogen-activated protein kinase 3 (EC:2.7.11.24) hsa:5599 MAPK8; mitogen-activated protein kinase 8 (EC:2.7.11.24) hsa:4790 NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 hsa:64127 NOD2; nucleotide-binding oligomerization domain containing 2 hsa:4843 NOS2; nitric oxide synthase 2, inducible (EC:1.14.13.39) hsa:5530 PPP3CA; protein phosphatase 3, catalytic subunit, alpha isozyme (EC:3.1.3.16) hsa:5894 RAF1; v-raf-1 murine leukemia viral oncogene homolog 1 (EC:2.7.11.1) hsa:5970 RELA; v-rel avian reticuloendotheliosis viral oncogene homolog A hsa:387 RHOA; ras homolog family member A hsa:6714 SRC; v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (EC:2.7.10.2) hsa:6772 STAT1; signal transducer and activator of transcription 1, 91kDa hsa:6850 SYK; spleen tyrosine kinase (EC:2.7.10.2) hsa:10312 TCIRG1; T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3 (EC:3.6.3.6) hsa:7040 TGFB1; transforming growth factor, beta 1 hsa:7042 TGFB2; transforming growth factor, beta 2 hsa:7096 TLR1; toll-like receptor 1 hsa:7097 TLR2; toll-like receptor 2 hsa:7099 TLR4; toll-like receptor 4 hsa:10333 TLR6; toll-like receptor 6 hsa:54106 TLR9; toll-like receptor 9 hsa:7124 TNF; tumor necrosis factor hsa:7132 TNFRSF1A; tumor necrosis factor receptor superfamily, member 1A hsa:8717 TRADD; TNFRSF1A-associated via death domain hsa:7189 TRAF6; TNF receptor-associated factor 6, E3 ubiquitin protein ligase

hsa05161 Hepatitis B - Homo sapiens (human) (71)

hsa:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) hsa:1386 ATF2; activating transcription factor 2 hsa:572 BAD; BCL2-associated agonist of cell death hsa:581 BAX; BCL2-associated X protein hsa:596 BCL2; B-cell CLL/lymphoma 2 hsa:332 BIRC5; baculoviral IAP repeat containing 5 hsa:836 CASP3; caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) hsa:841 CASP8; caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) hsa:842 CASP9; caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) hsa:595 CCND1; cyclin D1 hsa:1019 CDK4; cyclin-dependent kinase 4 (EC:2.7.11.22) hsa:1026 CDKN1A; cyclin-dependent kinase inhibitor 1A (p21, Cip1) hsa:1027 CDKN1B; cyclin-dependent kinase inhibitor 1B (p27, Kip1) hsa:1147 CHUK; conserved helix-loop-helix ubiquitous kinase (EC:2.7.11.10) hsa:1385 CREB1; cAMP responsive element binding protein 1 hsa:9586 CREB5; cAMP responsive element binding protein 5 hsa:54205 CYCS; cytochrome c, somatic hsa:23586 DDX58; DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 (EC:3.6.4.13) hsa:1869 E2F1; E2F transcription factor 1 hsa:1870 E2F2; E2F transcription factor 2 hsa:1959 EGR2; early growth response 2 hsa:2002 ELK1; ELK1, member of ETS oncogene family hsa:355 FAS; Fas cell surface death receptor hsa:2353 FOS; FBJ murine osteosarcoma viral oncogene homolog hsa:2885 GRB2; growth factor receptor-bound protein 2 hsa:64135 IFIH1; interferon induced with helicase C domain 1 (EC:3.6.4.13) hsa:3439 IFNA1; interferon, alpha 1 hsa:3445 IFNA8; interferon, alpha 8 hsa:3454 IFNAR1; interferon (alpha, beta and omega) receptor 1 hsa:3551 IKBKB; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta (EC:2.7.11.10) hsa:9641 IKBKE; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon (EC:2.7.11.10) hsa:8517 IKBKG; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma hsa:3569 IL6; interleukin 6 (interferon, beta 2) hsa:3576 IL8; interleukin 8 hsa:3725 JUN; jun proto-oncogene hsa:3845 KRAS; Kirsten rat sarcoma viral oncogene homolog hsa:5604 MAP2K1; mitogen-activated protein kinase kinase 1 (EC:2.7.12.2) hsa:6416 MAP2K4; mitogen-activated protein kinase kinase 4 (EC:2.7.12.2) hsa:4214 MAP3K1; mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase (EC:2.7.11.25) hsa:5594 MAPK1; mitogen-activated protein kinase 1 (EC:2.7.11.24) hsa:5595 MAPK3; mitogen-activated protein kinase 3 (EC:2.7.11.24) hsa:5599 MAPK8; mitogen-activated protein kinase 8 (EC:2.7.11.24) hsa:4318 MMP9; matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) hsa:4609 MYC; v-myc avian myelocytomatosis viral oncogene homolog hsa:4776 NFATC4; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 hsa:4790 NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 hsa:4792 NFKBIA; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha hsa:4893 NRAS; neuroblastoma RAS viral (v-ras) oncogene homolog hsa:5111 PCNA; proliferating cell nuclear antigen hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha) hsa:5578 PRKCA; protein kinase C, alpha (EC:2.7.11.13) hsa:5728 PTEN; phosphatase and tensin homolog (EC:3.1.3.67 3.1.3.16 3.1.3.48) hsa:5894 RAF1; v-raf-1 murine leukemia viral oncogene homolog 1 (EC:2.7.11.1) hsa:5970 RELA; v-rel avian reticuloendotheliosis viral oncogene homolog A hsa:6714 SRC; v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (EC:2.7.10.2) hsa:6772 STAT1; signal transducer and activator of transcription 1, 91kDa hsa:6773 STAT2; signal transducer and activator of transcription 2, 113kDa hsa:6774 STAT3; signal transducer and activator of transcription 3 (acute-phase response factor) hsa:6776 STAT5A; signal transducer and activator of transcription 5A hsa:6777 STAT5B; signal transducer and activator of transcription 5B hsa:6778 STAT6; signal transducer and activator of transcription 6, interleukin-4 induced hsa:7040 TGFB1; transforming growth factor, beta 1 hsa:7042 TGFB2; transforming growth factor, beta 2 hsa:148022 TICAM1; toll-like receptor adaptor molecule 1 hsa:7097 TLR2; toll-like receptor 2 hsa:7098 TLR3; toll-like receptor 3 hsa:7099 TLR4; toll-like receptor 4 hsa:7124 TNF; tumor necrosis factor hsa:7157 TP53; tumor protein p53 hsa:7529 YWHAB; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide hsa:10971 YWHAQ; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide

hsa04062 Chemokine signaling pathway - Homo sapiens (human) (65)

hsa:115 ADCY9; adenylate cyclase 9 (EC:4.6.1.1) hsa:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) hsa:408 ARRB1; arrestin, beta 1 hsa:673 BRAF; v-raf murine sarcoma viral oncogene homolog B (EC:2.7.11.1) hsa:6362 CCL18; chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) hsa:6363 CCL19; chemokine (C-C motif) ligand 19 hsa:6347 CCL2; chemokine (C-C motif) ligand 2 hsa:6364 CCL20; chemokine (C-C motif) ligand 20 hsa:6348 CCL3; chemokine (C-C motif) ligand 3 hsa:6351 CCL4; chemokine (C-C motif) ligand 4 hsa:6352 CCL5; chemokine (C-C motif) ligand 5 hsa:6354 CCL7; chemokine (C-C motif) ligand 7 hsa:998 CDC42; cell division cycle 42 hsa:1147 CHUK; conserved helix-loop-helix ubiquitous kinase (EC:2.7.11.10) hsa:1398 CRK; v-crk avian sarcoma virus CT10 oncogene homolog hsa:1399 CRKL; v-crk avian sarcoma virus CT10 oncogene homolog-like hsa:2919 CXCL1; chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) hsa:3627 CXCL10; chemokine (C-X-C motif) ligand 10 hsa:6373 CXCL11; chemokine (C-X-C motif) ligand 11 hsa:10563 CXCL13; chemokine (C-X-C motif) ligand 13 hsa:2920 CXCL2; chemokine (C-X-C motif) ligand 2 hsa:2921 CXCL3; chemokine (C-X-C motif) ligand 3 hsa:6374 CXCL5; chemokine (C-X-C motif) ligand 5 hsa:4283 CXCL9; chemokine (C-X-C motif) ligand 9 hsa:3579 CXCR2; chemokine (C-X-C motif) receptor 2 hsa:7852 CXCR4; chemokine (C-X-C motif) receptor 4 hsa:2783 GNB2; guanine nucleotide binding protein (G protein), beta polypeptide 2 hsa:2885 GRB2; growth factor receptor-bound protein 2 hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26) hsa:3055 HCK; hemopoietic cell kinase (EC:2.7.10.2) hsa:3551 IKBKB; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta (EC:2.7.11.10) hsa:8517 IKBKG; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma hsa:3576 IL8; interleukin 8 hsa:3717 JAK2; Janus kinase 2 (EC:2.7.10.2) hsa:3718 JAK3; Janus kinase 3 (EC:2.7.10.2) hsa:3845 KRAS; Kirsten rat sarcoma viral oncogene homolog hsa:4067 LYN; v-yes-1 Yamaguchi sarcoma viral related oncogene homolog (EC:2.7.10.2) hsa:5604 MAP2K1; mitogen-activated protein kinase kinase 1 (EC:2.7.12.2) hsa:5594 MAPK1; mitogen-activated protein kinase 1 (EC:2.7.11.24) hsa:5595 MAPK3; mitogen-activated protein kinase 3 (EC:2.7.11.24) hsa:4790 NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 hsa:4792 NFKBIA; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha hsa:4893 NRAS; neuroblastoma RAS viral (v-ras) oncogene homolog hsa:5058 PAK1; p21 protein (Cdc42/Rac)-activated kinase 1 (EC:2.7.11.1) hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha) hsa:5330 PLCB2; phospholipase C, beta 2 (EC:3.1.4.11) hsa:5332 PLCB4; phospholipase C, beta 4 (EC:3.1.4.11) hsa:5580 PRKCD; protein kinase C, delta (EC:2.7.10.2 2.7.11.13) hsa:5590 PRKCZ; protein kinase C, zeta (EC:2.7.11.13) hsa:5747 PTK2; protein tyrosine kinase 2 (EC:2.7.10.2) hsa:5829 PXN; paxillin hsa:5879 RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) hsa:5880 RAC2; ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) hsa:5894 RAF1; v-raf-1 murine leukemia viral oncogene homolog 1 (EC:2.7.11.1) hsa:5906 RAP1A; RAP1A, member of RAS oncogene family hsa:5970 RELA; v-rel avian reticuloendotheliosis viral oncogene homolog A hsa:387 RHOA; ras homolog family member A hsa:6654 SOS1; son of sevenless homolog 1 (Drosophila) hsa:6714 SRC; v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (EC:2.7.10.2) hsa:6772 STAT1; signal transducer and activator of transcription 1, 91kDa hsa:6773 STAT2; signal transducer and activator of transcription 2, 113kDa hsa:6774 STAT3; signal transducer and activator of transcription 3 (acute-phase response factor) hsa:6777 STAT5B; signal transducer and activator of transcription 5B hsa:7409 VAV1; vav 1 guanine nucleotide exchange factor hsa:8976 WASL; Wiskott-Aldrich syndrome-like

hsa04510 Focal adhesion - Homo sapiens (human) (63)

hsa:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) hsa:572 BAD; BCL2-associated agonist of cell death hsa:596 BCL2; B-cell CLL/lymphoma 2 hsa:329 BIRC2; baculoviral IAP repeat containing 2 hsa:330 BIRC3; baculoviral IAP repeat containing 3 hsa:673 BRAF; v-raf murine sarcoma viral oncogene homolog B (EC:2.7.11.1) hsa:857 CAV1; caveolin 1, caveolae protein, 22kDa hsa:595 CCND1; cyclin D1 hsa:998 CDC42; cell division cycle 42 hsa:1398 CRK; v-crk avian sarcoma virus CT10 oncogene homolog hsa:1399 CRKL; v-crk avian sarcoma virus CT10 oncogene homolog-like hsa:1499 CTNNB1; catenin (cadherin-associated protein), beta 1, 88kDa hsa:1793 DOCK1; dedicator of cytokinesis 1 hsa:1950 EGF; epidermal growth factor hsa:1956 EGFR; epidermal growth factor receptor (EC:2.7.10.1) hsa:2002 ELK1; ELK1, member of ETS oncogene family hsa:2064 ERBB2; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (EC:2.7.10.1) hsa:2324 FLT4; fms-related tyrosine kinase 4 (EC:2.7.10.1) hsa:2335 FN1; fibronectin 1 hsa:2534 FYN; FYN oncogene related to SRC, FGR, YES (EC:2.7.10.2) hsa:2885 GRB2; growth factor receptor-bound protein 2 hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26) hsa:3479 IGF1; insulin-like growth factor 1 (somatomedin C) hsa:3611 ILK; integrin-linked kinase (EC:2.7.11.1) hsa:3673 ITGA2; integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) hsa:3678 ITGA5; integrin, alpha 5 (fibronectin receptor, alpha polypeptide) hsa:3688 ITGB1; integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) hsa:3691 ITGB4; integrin, beta 4 hsa:3725 JUN; jun proto-oncogene hsa:284217 LAMA1; laminin, alpha 1 hsa:3912 LAMB1; laminin, beta 1 hsa:3915 LAMC1; laminin, gamma 1 (formerly LAMB2) hsa:5604 MAP2K1; mitogen-activated protein kinase kinase 1 (EC:2.7.12.2) hsa:5594 MAPK1; mitogen-activated protein kinase 1 (EC:2.7.11.24) hsa:5595 MAPK3; mitogen-activated protein kinase 3 (EC:2.7.11.24) hsa:5599 MAPK8; mitogen-activated protein kinase 8 (EC:2.7.11.24) hsa:4233 MET; met proto-oncogene (EC:2.7.10.1) hsa:4638 MYLK; myosin light chain kinase (EC:2.7.11.18) hsa:5058 PAK1; p21 protein (Cdc42/Rac)-activated kinase 1 (EC:2.7.11.1) hsa:5062 PAK2; p21 protein (Cdc42/Rac)-activated kinase 2 (EC:2.7.11.1) hsa:5154 PDGFA; platelet-derived growth factor alpha polypeptide hsa:5155 PDGFB; platelet-derived growth factor beta polypeptide hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha) hsa:5578 PRKCA; protein kinase C, alpha (EC:2.7.11.13) hsa:5728 PTEN; phosphatase and tensin homolog (EC:3.1.3.67 3.1.3.16 3.1.3.48) hsa:5747 PTK2; protein tyrosine kinase 2 (EC:2.7.10.2) hsa:5829 PXN; paxillin hsa:5879 RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) hsa:5880 RAC2; ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) hsa:5894 RAF1; v-raf-1 murine leukemia viral oncogene homolog 1 (EC:2.7.11.1) hsa:5906 RAP1A; RAP1A, member of RAS oncogene family hsa:387 RHOA; ras homolog family member A hsa:6654 SOS1; son of sevenless homolog 1 (Drosophila) hsa:6714 SRC; v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (EC:2.7.10.2) hsa:7057 THBS1; thrombospondin 1 hsa:7094 TLN1; talin 1 hsa:7408 VASP; vasodilator-stimulated phosphoprotein hsa:7409 VAV1; vav 1 guanine nucleotide exchange factor hsa:7414 VCL; vinculin hsa:7422 VEGFA; vascular endothelial growth factor A hsa:7424 VEGFC; vascular endothelial growth factor C hsa:7448 VTN; vitronectin hsa:7450 VWF; von Willebrand factor

hsa05164 Influenza A - Homo sapiens (human) (62)

cpd:C00027 Hydrogen peroxide cpd:C00080 H+ hsa:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) hsa:1386 ATF2; activating transcription factor 2 hsa:842 CASP9; caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) hsa:6347 CCL2; chemokine (C-C motif) ligand 2 hsa:6352 CCL5; chemokine (C-C motif) ligand 5 hsa:4261 CIITA; class II, major histocompatibility complex, transactivator hsa:3627 CXCL10; chemokine (C-X-C motif) ligand 10 hsa:54205 CYCS; cytochrome c, somatic hsa:23586 DDX58; DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 (EC:3.6.4.13) hsa:355 FAS; Fas cell surface death receptor hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26) hsa:3108 HLA-DMA; major histocompatibility complex, class II, DM alpha hsa:3117 HLA-DQA1; major histocompatibility complex, class II, DQ alpha 1 hsa:3119 HLA-DQB1; major histocompatibility complex, class II, DQ beta 1 hsa:3122 HLA-DRA; major histocompatibility complex, class II, DR alpha hsa:3125 HLA-DRB3; major histocompatibility complex, class II, DR beta 3 hsa:3127 HLA-DRB5; major histocompatibility complex, class II, DR beta 5 hsa:3312 HSPA8; heat shock 70kDa protein 8 hsa:3383 ICAM1; intercellular adhesion molecule 1 hsa:64135 IFIH1; interferon induced with helicase C domain 1 (EC:3.6.4.13) hsa:3439 IFNA1; interferon, alpha 1 hsa:3445 IFNA8; interferon, alpha 8 hsa:3454 IFNAR1; interferon (alpha, beta and omega) receptor 1 hsa:3455 IFNAR2; interferon (alpha, beta and omega) receptor 2 hsa:3458 IFNG; interferon, gamma hsa:3459 IFNGR1; interferon gamma receptor 1 hsa:3551 IKBKB; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta (EC:2.7.11.10) hsa:9641 IKBKE; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon (EC:2.7.11.10) hsa:3552 IL1A; interleukin 1, alpha hsa:3553 IL1B; interleukin 1, beta hsa:3569 IL6; interleukin 6 (interferon, beta 2) hsa:3576 IL8; interleukin 8 hsa:3717 JAK2; Janus kinase 2 (EC:2.7.10.2) hsa:3725 JUN; jun proto-oncogene hsa:5604 MAP2K1; mitogen-activated protein kinase kinase 1 (EC:2.7.12.2) hsa:5606 MAP2K3; mitogen-activated protein kinase kinase 3 (EC:2.7.12.2) hsa:6416 MAP2K4; mitogen-activated protein kinase kinase 4 (EC:2.7.12.2) hsa:5594 MAPK1; mitogen-activated protein kinase 1 (EC:2.7.11.24) hsa:1432 MAPK14; mitogen-activated protein kinase 14 (EC:2.7.11.24) hsa:5595 MAPK3; mitogen-activated protein kinase 3 (EC:2.7.11.24) hsa:5599 MAPK8; mitogen-activated protein kinase 8 (EC:2.7.11.24) hsa:4790 NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 hsa:4792 NFKBIA; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha hsa:4938 OAS1; 2'-5'-oligoadenylate synthetase 1, 40/46kDa (EC:2.7.7.84) hsa:4939 OAS2; 2'-5'-oligoadenylate synthetase 2, 69/71kDa (EC:2.7.7.84) hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha) hsa:5340 PLG; plasminogen (EC:3.4.21.7) hsa:5578 PRKCA; protein kinase C, alpha (EC:2.7.11.13) hsa:5644 PRSS1; protease, serine, 1 (trypsin 1) (EC:3.4.21.4) hsa:5894 RAF1; v-raf-1 murine leukemia viral oncogene homolog 1 (EC:2.7.11.1) hsa:5970 RELA; v-rel avian reticuloendotheliosis viral oncogene homolog A hsa:91543 RSAD2; radical S-adenosyl methionine domain containing 2 hsa:6772 STAT1; signal transducer and activator of transcription 1, 91kDa hsa:6773 STAT2; signal transducer and activator of transcription 2, 113kDa hsa:148022 TICAM1; toll-like receptor adaptor molecule 1 hsa:7098 TLR3; toll-like receptor 3 hsa:7099 TLR4; toll-like receptor 4 hsa:51284 TLR7; toll-like receptor 7 hsa:7124 TNF; tumor necrosis factor hsa:7132 TNFRSF1A; tumor necrosis factor receptor superfamily, member 1A

hsa04810 Regulation of actin cytoskeleton - Homo sapiens (human) (62)

cpd:C00338 Lipopolysaccharide hsa:324 APC; adenomatous polyposis coli hsa:9459 ARHGEF6; Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6 hsa:10093 ARPC4; actin related protein 2/3 complex, subunit 4, 20kDa hsa:673 BRAF; v-raf murine sarcoma viral oncogene homolog B (EC:2.7.11.1) hsa:929 CD14; CD14 molecule hsa:998 CDC42; cell division cycle 42 hsa:1129 CHRM2; cholinergic receptor, muscarinic 2 hsa:1398 CRK; v-crk avian sarcoma virus CT10 oncogene homolog hsa:1399 CRKL; v-crk avian sarcoma virus CT10 oncogene homolog-like hsa:1793 DOCK1; dedicator of cytokinesis 1 hsa:1950 EGF; epidermal growth factor hsa:1956 EGFR; epidermal growth factor receptor (EC:2.7.10.1) hsa:7430 EZR; ezrin hsa:2147 F2; coagulation factor II (thrombin) (EC:3.4.21.5) hsa:2149 F2R; coagulation factor II (thrombin) receptor hsa:2258 FGF13; fibroblast growth factor 13 hsa:2247 FGF2; fibroblast growth factor 2 (basic) hsa:26281 FGF20; fibroblast growth factor 20 hsa:2263 FGFR2; fibroblast growth factor receptor 2 (EC:2.7.10.1) hsa:2261 FGFR3; fibroblast growth factor receptor 3 (EC:2.7.10.1) hsa:2335 FN1; fibronectin 1 hsa:28964 GIT1; G protein-coupled receptor kinase interacting ArfGAP 1 hsa:10788 IQGAP2; IQ motif containing GTPase activating protein 2 hsa:3673 ITGA2; integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) hsa:3678 ITGA5; integrin, alpha 5 (fibronectin receptor, alpha polypeptide) hsa:3681 ITGAD; integrin, alpha D hsa:3683 ITGAL; integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) hsa:3684 ITGAM; integrin, alpha M (complement component 3 receptor 3 subunit) hsa:3687 ITGAX; integrin, alpha X (complement component 3 receptor 4 subunit) hsa:3688 ITGB1; integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) hsa:3689 ITGB2; integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) hsa:3691 ITGB4; integrin, beta 4 hsa:3845 KRAS; Kirsten rat sarcoma viral oncogene homolog hsa:5604 MAP2K1; mitogen-activated protein kinase kinase 1 (EC:2.7.12.2) hsa:5594 MAPK1; mitogen-activated protein kinase 1 (EC:2.7.11.24) hsa:5595 MAPK3; mitogen-activated protein kinase 3 (EC:2.7.11.24) hsa:4478 MSN; moesin hsa:4638 MYLK; myosin light chain kinase (EC:2.7.11.18) hsa:4893 NRAS; neuroblastoma RAS viral (v-ras) oncogene homolog hsa:5058 PAK1; p21 protein (Cdc42/Rac)-activated kinase 1 (EC:2.7.11.1) hsa:5062 PAK2; p21 protein (Cdc42/Rac)-activated kinase 2 (EC:2.7.11.1) hsa:5154 PDGFA; platelet-derived growth factor alpha polypeptide hsa:5155 PDGFB; platelet-derived growth factor beta polypeptide hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha) hsa:200576 PIKFYVE; phosphoinositide kinase, FYVE finger containing (EC:2.7.1.150) hsa:8395 PIP5K1B; phosphatidylinositol-4-phosphate 5-kinase, type I, beta (EC:2.7.1.68) hsa:5747 PTK2; protein tyrosine kinase 2 (EC:2.7.10.2) hsa:5829 PXN; paxillin hsa:5879 RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) hsa:5880 RAC2; ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) hsa:5894 RAF1; v-raf-1 murine leukemia viral oncogene homolog 1 (EC:2.7.11.1) hsa:387 RHOA; ras homolog family member A hsa:6237 RRAS; related RAS viral (r-ras) oncogene homolog hsa:22800 RRAS2; related RAS viral (r-ras) oncogene homolog 2 hsa:6654 SOS1; son of sevenless homolog 1 (Drosophila) hsa:6714 SRC; v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (EC:2.7.10.2) hsa:7114 TMSB4X; thymosin beta 4, X-linked hsa:7409 VAV1; vav 1 guanine nucleotide exchange factor hsa:7414 VCL; vinculin hsa:8936 WASF1; WAS protein family, member 1 hsa:8976 WASL; Wiskott-Aldrich syndrome-like

hsa05168 Herpes simplex infection - Homo sapiens (human) (59)

hsa:406 ARNTL; aryl hydrocarbon receptor nuclear translocator-like hsa:718 C3; complement component 3 (EC:3.4.21.43) hsa:836 CASP3; caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) hsa:841 CASP8; caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) hsa:6347 CCL2; chemokine (C-C motif) ligand 2 hsa:6352 CCL5; chemokine (C-C motif) ligand 5 hsa:972 CD74; CD74 molecule, major histocompatibility complex, class II invariant chain hsa:1147 CHUK; conserved helix-loop-helix ubiquitous kinase (EC:2.7.11.10) hsa:1457 CSNK2A1; casein kinase 2, alpha 1 polypeptide (EC:2.7.11.1) hsa:54205 CYCS; cytochrome c, somatic hsa:23586 DDX58; DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 (EC:3.6.4.13) hsa:355 FAS; Fas cell surface death receptor hsa:2353 FOS; FBJ murine osteosarcoma viral oncogene homolog hsa:3106 HLA-B; major histocompatibility complex, class I, B hsa:3108 HLA-DMA; major histocompatibility complex, class II, DM alpha hsa:3117 HLA-DQA1; major histocompatibility complex, class II, DQ alpha 1 hsa:3119 HLA-DQB1; major histocompatibility complex, class II, DQ beta 1 hsa:3122 HLA-DRA; major histocompatibility complex, class II, DR alpha hsa:3125 HLA-DRB3; major histocompatibility complex, class II, DR beta 3 hsa:3127 HLA-DRB5; major histocompatibility complex, class II, DR beta 5 hsa:3134 HLA-F; major histocompatibility complex, class I, F hsa:3150 HMGN1; high mobility group nucleosome binding domain 1 hsa:3190 HNRNPK; heterogeneous nuclear ribonucleoprotein K hsa:64135 IFIH1; interferon induced with helicase C domain 1 (EC:3.6.4.13) hsa:3434 IFIT1; interferon-induced protein with tetratricopeptide repeats 1 hsa:3439 IFNA1; interferon, alpha 1 hsa:3445 IFNA8; interferon, alpha 8 hsa:3454 IFNAR1; interferon (alpha, beta and omega) receptor 1 hsa:3455 IFNAR2; interferon (alpha, beta and omega) receptor 2 hsa:3458 IFNG; interferon, gamma hsa:3459 IFNGR1; interferon gamma receptor 1 hsa:3551 IKBKB; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta (EC:2.7.11.10) hsa:9641 IKBKE; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon (EC:2.7.11.10) hsa:8517 IKBKG; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma hsa:3553 IL1B; interleukin 1, beta hsa:3569 IL6; interleukin 6 (interferon, beta 2) hsa:3717 JAK2; Janus kinase 2 (EC:2.7.10.2) hsa:3725 JUN; jun proto-oncogene hsa:6885 MAP3K7; mitogen-activated protein kinase kinase kinase 7 (EC:2.7.11.25) hsa:5599 MAPK8; mitogen-activated protein kinase 8 (EC:2.7.11.24) hsa:4790 NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 hsa:4792 NFKBIA; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha hsa:4938 OAS1; 2'-5'-oligoadenylate synthetase 1, 40/46kDa (EC:2.7.7.84) hsa:4939 OAS2; 2'-5'-oligoadenylate synthetase 2, 69/71kDa (EC:2.7.7.84) hsa:5781 PTPN11; protein tyrosine phosphatase, non-receptor type 11 (EC:3.1.3.48) hsa:5970 RELA; v-rel avian reticuloendotheliosis viral oncogene homolog A hsa:6502 SKP2; S-phase kinase-associated protein 2, E3 ubiquitin protein ligase hsa:6772 STAT1; signal transducer and activator of transcription 1, 91kDa hsa:6773 STAT2; signal transducer and activator of transcription 2, 113kDa hsa:6884 TAF13; TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa hsa:148022 TICAM1; toll-like receptor adaptor molecule 1 hsa:7097 TLR2; toll-like receptor 2 hsa:7098 TLR3; toll-like receptor 3 hsa:54106 TLR9; toll-like receptor 9 hsa:7124 TNF; tumor necrosis factor hsa:7132 TNFRSF1A; tumor necrosis factor receptor superfamily, member 1A hsa:7157 TP53; tumor protein p53 hsa:7189 TRAF6; TNF receptor-associated factor 6, E3 ubiquitin protein ligase hsa:7874 USP7; ubiquitin specific peptidase 7 (herpes virus-associated) (EC:3.4.19.12)

hsa05206 MicroRNAs in cancer - Homo sapiens (human) (59)

hsa:5243 ABCB1; ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) hsa:25 ABL1; c-abl oncogene 1, non-receptor tyrosine kinase (EC:2.7.10.2) hsa:324 APC; adenomatous polyposis coli hsa:472 ATM; ataxia telangiectasia mutated (EC:2.7.11.1) hsa:596 BCL2; B-cell CLL/lymphoma 2 hsa:672 BRCA1; breast cancer 1, early onset hsa:836 CASP3; caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) hsa:595 CCND1; cyclin D1 hsa:960 CD44; CD44 molecule (Indian blood group) hsa:1026 CDKN1A; cyclin-dependent kinase inhibitor 1A (p21, Cip1) hsa:1027 CDKN1B; cyclin-dependent kinase inhibitor 1B (p27, Kip1) hsa:1029 CDKN2A; cyclin-dependent kinase inhibitor 2A hsa:1398 CRK; v-crk avian sarcoma virus CT10 oncogene homolog hsa:1399 CRKL; v-crk avian sarcoma virus CT10 oncogene homolog-like hsa:1789 DNMT3B; DNA (cytosine-5-)-methyltransferase 3 beta (EC:2.1.1.37) hsa:1869 E2F1; E2F transcription factor 1 hsa:1870 E2F2; E2F transcription factor 2 hsa:1956 EGFR; epidermal growth factor receptor (EC:2.7.10.1) hsa:2064 ERBB2; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (EC:2.7.10.1) hsa:2146 EZH2; enhancer of zeste homolog 2 (Drosophila) (EC:2.1.1.43) hsa:7430 EZR; ezrin hsa:2261 FGFR3; fibroblast growth factor receptor 3 (EC:2.7.10.1) hsa:2885 GRB2; growth factor receptor-bound protein 2 hsa:3162 HMOX1; heme oxygenase (decycling) 1 (EC:1.14.99.3) hsa:3190 HNRNPK; heterogeneous nuclear ribonucleoprotein K hsa:3236 HOXD10; homeobox D10 hsa:3551 IKBKB; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta (EC:2.7.11.10) hsa:3667 IRS1; insulin receptor substrate 1 hsa:3678 ITGA5; integrin, alpha 5 (fibronectin receptor, alpha polypeptide) hsa:3845 KRAS; Kirsten rat sarcoma viral oncogene homolog hsa:5604 MAP2K1; mitogen-activated protein kinase kinase 1 (EC:2.7.12.2) hsa:5594 MAPK1; mitogen-activated protein kinase 1 (EC:2.7.11.24) hsa:4170 MCL1; myeloid cell leukemia sequence 1 (BCL2-related) hsa:4193 MDM2; MDM2 oncogene, E3 ubiquitin protein ligase hsa:4233 MET; met proto-oncogene (EC:2.7.10.1) hsa:406938 MIR146A; microRNA 146a hsa:442918 MIR373; microRNA 373 hsa:4318 MMP9; matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) hsa:4609 MYC; v-myc avian myelocytomatosis viral oncogene homolog hsa:4790 NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 hsa:4853 NOTCH2; notch 2 hsa:4893 NRAS; neuroblastoma RAS viral (v-ras) oncogene homolog hsa:5154 PDGFA; platelet-derived growth factor alpha polypeptide hsa:5155 PDGFB; platelet-derived growth factor beta polypeptide hsa:5328 PLAU; plasminogen activator, urokinase (EC:3.4.21.73) hsa:5335 PLCG1; phospholipase C, gamma 1 (EC:3.1.4.11) hsa:5578 PRKCA; protein kinase C, alpha (EC:2.7.11.13) hsa:5728 PTEN; phosphatase and tensin homolog (EC:3.1.3.67 3.1.3.16 3.1.3.48) hsa:5743 PTGS2; prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) hsa:5894 RAF1; v-raf-1 murine leukemia viral oncogene homolog 1 (EC:2.7.11.1) hsa:387 RHOA; ras homolog family member A hsa:9252 RPS6KA5; ribosomal protein S6 kinase, 90kDa, polypeptide 5 (EC:2.7.11.1) hsa:6654 SOS1; son of sevenless homolog 1 (Drosophila) hsa:6774 STAT3; signal transducer and activator of transcription 3 (acute-phase response factor) hsa:7042 TGFB2; transforming growth factor, beta 2 hsa:7057 THBS1; thrombospondin 1 hsa:7157 TP53; tumor protein p53 hsa:7422 VEGFA; vascular endothelial growth factor A hsa:7431 VIM; vimentin

hsa05162 Measles - Homo sapiens (human) (58)

hsa:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) hsa:595 CCND1; cyclin D1 hsa:30835 CD209; CD209 molecule hsa:915 CD3D; CD3d molecule, delta (CD3-TCR complex) hsa:4179 CD46; CD46 molecule, complement regulatory protein hsa:1019 CDK4; cyclin-dependent kinase 4 (EC:2.7.11.22) hsa:1027 CDKN1B; cyclin-dependent kinase inhibitor 1B (p27, Kip1) hsa:1147 CHUK; conserved helix-loop-helix ubiquitous kinase (EC:2.7.11.10) hsa:1457 CSNK2A1; casein kinase 2, alpha 1 polypeptide (EC:2.7.11.1) hsa:23586 DDX58; DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 (EC:3.6.4.13) hsa:1796 DOK1; docking protein 1, 62kDa (downstream of tyrosine kinase 1) hsa:355 FAS; Fas cell surface death receptor hsa:2534 FYN; FYN oncogene related to SRC, FGR, YES (EC:2.7.10.2) hsa:10399 GNB2L1; guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1 hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26) hsa:3312 HSPA8; heat shock 70kDa protein 8 hsa:64135 IFIH1; interferon induced with helicase C domain 1 (EC:3.6.4.13) hsa:3439 IFNA1; interferon, alpha 1 hsa:3445 IFNA8; interferon, alpha 8 hsa:3454 IFNAR1; interferon (alpha, beta and omega) receptor 1 hsa:3455 IFNAR2; interferon (alpha, beta and omega) receptor 2 hsa:3458 IFNG; interferon, gamma hsa:3459 IFNGR1; interferon gamma receptor 1 hsa:9641 IKBKE; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon (EC:2.7.11.10) hsa:3596 IL13; interleukin 13 hsa:3552 IL1A; interleukin 1, alpha hsa:3553 IL1B; interleukin 1, beta hsa:3558 IL2; interleukin 2 hsa:3559 IL2RA; interleukin 2 receptor, alpha hsa:3560 IL2RB; interleukin 2 receptor, beta hsa:3561 IL2RG; interleukin 2 receptor, gamma hsa:3565 IL4; interleukin 4 hsa:3569 IL6; interleukin 6 (interferon, beta 2) hsa:3654 IRAK1; interleukin-1 receptor-associated kinase 1 (EC:2.7.11.1) hsa:3717 JAK2; Janus kinase 2 (EC:2.7.10.2) hsa:3718 JAK3; Janus kinase 3 (EC:2.7.10.2) hsa:6885 MAP3K7; mitogen-activated protein kinase kinase kinase 7 (EC:2.7.11.25) hsa:4478 MSN; moesin hsa:4790 NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 hsa:4792 NFKBIA; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha hsa:4938 OAS1; 2'-5'-oligoadenylate synthetase 1, 40/46kDa (EC:2.7.7.84) hsa:4939 OAS2; 2'-5'-oligoadenylate synthetase 2, 69/71kDa (EC:2.7.7.84) hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha) hsa:5588 PRKCQ; protein kinase C, theta (EC:2.7.11.13) hsa:5970 RELA; v-rel avian reticuloendotheliosis viral oncogene homolog A hsa:6504 SLAMF1; signaling lymphocytic activation molecule family member 1 hsa:6772 STAT1; signal transducer and activator of transcription 1, 91kDa hsa:6773 STAT2; signal transducer and activator of transcription 2, 113kDa hsa:6774 STAT3; signal transducer and activator of transcription 3 (acute-phase response factor) hsa:6776 STAT5A; signal transducer and activator of transcription 5A hsa:6777 STAT5B; signal transducer and activator of transcription 5B hsa:7097 TLR2; toll-like receptor 2 hsa:7099 TLR4; toll-like receptor 4 hsa:51284 TLR7; toll-like receptor 7 hsa:54106 TLR9; toll-like receptor 9 hsa:7157 TP53; tumor protein p53 hsa:7161 TP73; tumor protein p73 hsa:7189 TRAF6; TNF receptor-associated factor 6, E3 ubiquitin protein ligase

hsa04668 TNF signaling pathway - Homo sapiens (human) (55)

hsa:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) hsa:1386 ATF2; activating transcription factor 2 hsa:329 BIRC2; baculoviral IAP repeat containing 2 hsa:330 BIRC3; baculoviral IAP repeat containing 3 hsa:836 CASP3; caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) hsa:840 CASP7; caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) hsa:841 CASP8; caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) hsa:6347 CCL2; chemokine (C-C motif) ligand 2 hsa:6364 CCL20; chemokine (C-C motif) ligand 20 hsa:6352 CCL5; chemokine (C-C motif) ligand 5 hsa:1147 CHUK; conserved helix-loop-helix ubiquitous kinase (EC:2.7.11.10) hsa:1385 CREB1; cAMP responsive element binding protein 1 hsa:9586 CREB5; cAMP responsive element binding protein 5 hsa:1437 CSF2; colony stimulating factor 2 (granulocyte-macrophage) hsa:2919 CXCL1; chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) hsa:3627 CXCL10; chemokine (C-X-C motif) ligand 10 hsa:2920 CXCL2; chemokine (C-X-C motif) ligand 2 hsa:2921 CXCL3; chemokine (C-X-C motif) ligand 3 hsa:6374 CXCL5; chemokine (C-X-C motif) ligand 5 hsa:10059 DNM1L; dynamin 1-like (EC:3.6.5.5) hsa:355 FAS; Fas cell surface death receptor hsa:2353 FOS; FBJ murine osteosarcoma viral oncogene homolog hsa:3383 ICAM1; intercellular adhesion molecule 1 hsa:3551 IKBKB; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta (EC:2.7.11.10) hsa:8517 IKBKG; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma hsa:3553 IL1B; interleukin 1, beta hsa:3569 IL6; interleukin 6 (interferon, beta 2) hsa:182 JAG1; jagged 1 hsa:3725 JUN; jun proto-oncogene hsa:3726 JUNB; jun B proto-oncogene hsa:3976 LIF; leukemia inhibitory factor hsa:5604 MAP2K1; mitogen-activated protein kinase kinase 1 (EC:2.7.12.2) hsa:5606 MAP2K3; mitogen-activated protein kinase kinase 3 (EC:2.7.12.2) hsa:6416 MAP2K4; mitogen-activated protein kinase kinase 4 (EC:2.7.12.2) hsa:9020 MAP3K14; mitogen-activated protein kinase kinase kinase 14 (EC:2.7.11.25) hsa:6885 MAP3K7; mitogen-activated protein kinase kinase kinase 7 (EC:2.7.11.25) hsa:5594 MAPK1; mitogen-activated protein kinase 1 (EC:2.7.11.24) hsa:1432 MAPK14; mitogen-activated protein kinase 14 (EC:2.7.11.24) hsa:5595 MAPK3; mitogen-activated protein kinase 3 (EC:2.7.11.24) hsa:5599 MAPK8; mitogen-activated protein kinase 8 (EC:2.7.11.24) hsa:197259 MLKL; mixed lineage kinase domain-like hsa:4318 MMP9; matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) hsa:4790 NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 hsa:4792 NFKBIA; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha hsa:64127 NOD2; nucleotide-binding oligomerization domain containing 2 hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha) hsa:5743 PTGS2; prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) hsa:5970 RELA; v-rel avian reticuloendotheliosis viral oncogene homolog A hsa:9252 RPS6KA5; ribosomal protein S6 kinase, 90kDa, polypeptide 5 (EC:2.7.11.1) hsa:7124 TNF; tumor necrosis factor hsa:7132 TNFRSF1A; tumor necrosis factor receptor superfamily, member 1A hsa:7133 TNFRSF1B; tumor necrosis factor receptor superfamily, member 1B hsa:8717 TRADD; TNFRSF1A-associated via death domain hsa:7412 VCAM1; vascular cell adhesion molecule 1 hsa:7424 VEGFC; vascular endothelial growth factor C

hsa05145 Toxoplasmosis - Homo sapiens (human) (55)

hsa:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) hsa:240 ALOX5; arachidonate 5-lipoxygenase (EC:1.13.11.34) hsa:572 BAD; BCL2-associated agonist of cell death hsa:596 BCL2; B-cell CLL/lymphoma 2 hsa:598 BCL2L1; BCL2-like 1 hsa:329 BIRC2; baculoviral IAP repeat containing 2 hsa:330 BIRC3; baculoviral IAP repeat containing 3 hsa:836 CASP3; caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) hsa:841 CASP8; caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) hsa:842 CASP9; caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) hsa:1147 CHUK; conserved helix-loop-helix ubiquitous kinase (EC:2.7.11.10) hsa:4261 CIITA; class II, major histocompatibility complex, transactivator hsa:54205 CYCS; cytochrome c, somatic hsa:3108 HLA-DMA; major histocompatibility complex, class II, DM alpha hsa:3117 HLA-DQA1; major histocompatibility complex, class II, DQ alpha 1 hsa:3119 HLA-DQB1; major histocompatibility complex, class II, DQ beta 1 hsa:3122 HLA-DRA; major histocompatibility complex, class II, DR alpha hsa:3125 HLA-DRB3; major histocompatibility complex, class II, DR beta 3 hsa:3127 HLA-DRB5; major histocompatibility complex, class II, DR beta 5 hsa:3312 HSPA8; heat shock 70kDa protein 8 hsa:3458 IFNG; interferon, gamma hsa:3459 IFNGR1; interferon gamma receptor 1 hsa:3551 IKBKB; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta (EC:2.7.11.10) hsa:8517 IKBKG; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma hsa:3586 IL10; interleukin 10 hsa:3587 IL10RA; interleukin 10 receptor, alpha hsa:3654 IRAK1; interleukin-1 receptor-associated kinase 1 (EC:2.7.11.1) hsa:345611 IRGM; immunity-related GTPase family, M hsa:3688 ITGB1; integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) hsa:3717 JAK2; Janus kinase 2 (EC:2.7.10.2) hsa:284217 LAMA1; laminin, alpha 1 hsa:3912 LAMB1; laminin, beta 1 hsa:3915 LAMC1; laminin, gamma 1 (formerly LAMB2) hsa:3949 LDLR; low density lipoprotein receptor hsa:23643 LY96; lymphocyte antigen 96 hsa:5606 MAP2K3; mitogen-activated protein kinase kinase 3 (EC:2.7.12.2) hsa:6885 MAP3K7; mitogen-activated protein kinase kinase kinase 7 (EC:2.7.11.25) hsa:5594 MAPK1; mitogen-activated protein kinase 1 (EC:2.7.11.24) hsa:1432 MAPK14; mitogen-activated protein kinase 14 (EC:2.7.11.24) hsa:5595 MAPK3; mitogen-activated protein kinase 3 (EC:2.7.11.24) hsa:5599 MAPK8; mitogen-activated protein kinase 8 (EC:2.7.11.24) hsa:4790 NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 hsa:4792 NFKBIA; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha hsa:4843 NOS2; nitric oxide synthase 2, inducible (EC:1.14.13.39) hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha) hsa:5970 RELA; v-rel avian reticuloendotheliosis viral oncogene homolog A hsa:6772 STAT1; signal transducer and activator of transcription 1, 91kDa hsa:6774 STAT3; signal transducer and activator of transcription 3 (acute-phase response factor) hsa:7040 TGFB1; transforming growth factor, beta 1 hsa:7042 TGFB2; transforming growth factor, beta 2 hsa:7097 TLR2; toll-like receptor 2 hsa:7099 TLR4; toll-like receptor 4 hsa:7124 TNF; tumor necrosis factor hsa:7132 TNFRSF1A; tumor necrosis factor receptor superfamily, member 1A hsa:7189 TRAF6; TNF receptor-associated factor 6, E3 ubiquitin protein ligase

hsa05169 Epstein-Barr virus infection - Homo sapiens (human) (54)

hsa:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) hsa:1386 ATF2; activating transcription factor 2 hsa:596 BCL2; B-cell CLL/lymphoma 2 hsa:960 CD44; CD44 molecule (Indian blood group) hsa:1026 CDKN1A; cyclin-dependent kinase inhibitor 1A (p21, Cip1) hsa:1027 CDKN1B; cyclin-dependent kinase inhibitor 1B (p27, Kip1) hsa:1147 CHUK; conserved helix-loop-helix ubiquitous kinase (EC:2.7.11.10) hsa:1457 CSNK2A1; casein kinase 2, alpha 1 polypeptide (EC:2.7.11.1) hsa:23586 DDX58; DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 (EC:3.6.4.13) hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26) hsa:3106 HLA-B; major histocompatibility complex, class I, B hsa:3117 HLA-DQA1; major histocompatibility complex, class II, DQ alpha 1 hsa:3119 HLA-DQB1; major histocompatibility complex, class II, DQ beta 1 hsa:3122 HLA-DRA; major histocompatibility complex, class II, DR alpha hsa:3125 HLA-DRB3; major histocompatibility complex, class II, DR beta 3 hsa:3127 HLA-DRB5; major histocompatibility complex, class II, DR beta 5 hsa:3134 HLA-F; major histocompatibility complex, class I, F hsa:3312 HSPA8; heat shock 70kDa protein 8 hsa:3383 ICAM1; intercellular adhesion molecule 1 hsa:3458 IFNG; interferon, gamma hsa:3551 IKBKB; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta (EC:2.7.11.10) hsa:8517 IKBKG; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma hsa:3586 IL10; interleukin 10 hsa:3587 IL10RA; interleukin 10 receptor, alpha hsa:3654 IRAK1; interleukin-1 receptor-associated kinase 1 (EC:2.7.11.1) hsa:3683 ITGAL; integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) hsa:3718 JAK3; Janus kinase 3 (EC:2.7.10.2) hsa:3725 JUN; jun proto-oncogene hsa:4067 LYN; v-yes-1 Yamaguchi sarcoma viral related oncogene homolog (EC:2.7.10.2) hsa:5606 MAP2K3; mitogen-activated protein kinase kinase 3 (EC:2.7.12.2) hsa:6416 MAP2K4; mitogen-activated protein kinase kinase 4 (EC:2.7.12.2) hsa:9020 MAP3K14; mitogen-activated protein kinase kinase kinase 14 (EC:2.7.11.25) hsa:6885 MAP3K7; mitogen-activated protein kinase kinase kinase 7 (EC:2.7.11.25) hsa:1432 MAPK14; mitogen-activated protein kinase 14 (EC:2.7.11.24) hsa:5599 MAPK8; mitogen-activated protein kinase 8 (EC:2.7.11.24) hsa:4193 MDM2; MDM2 oncogene, E3 ubiquitin protein ligase hsa:4609 MYC; v-myc avian myelocytomatosis viral oncogene homolog hsa:4790 NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 hsa:4792 NFKBIA; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha) hsa:5335 PLCG1; phospholipase C, gamma 1 (EC:3.1.4.11) hsa:10621 POLR3F; polymerase (RNA) III (DNA directed) polypeptide F, 39 kDa hsa:5702 PSMC3; proteasome (prosome, macropain) 26S subunit, ATPase, 3 hsa:5970 RELA; v-rel avian reticuloendotheliosis viral oncogene homolog A hsa:6502 SKP2; S-phase kinase-associated protein 2, E3 ubiquitin protein ligase hsa:6774 STAT3; signal transducer and activator of transcription 3 (acute-phase response factor) hsa:6850 SYK; spleen tyrosine kinase (EC:2.7.10.2) hsa:7157 TP53; tumor protein p53 hsa:8717 TRADD; TNFRSF1A-associated via death domain hsa:7189 TRAF6; TNF receptor-associated factor 6, E3 ubiquitin protein ligase hsa:7874 USP7; ubiquitin specific peptidase 7 (herpes virus-associated) (EC:3.4.19.12) hsa:7431 VIM; vimentin hsa:7529 YWHAB; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide hsa:10971 YWHAQ; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide

hsa05203 Viral carcinogenesis - Homo sapiens (human) (52)

hsa:1386 ATF2; activating transcription factor 2 hsa:572 BAD; BCL2-associated agonist of cell death hsa:581 BAX; BCL2-associated X protein hsa:718 C3; complement component 3 (EC:3.4.21.43) hsa:836 CASP3; caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) hsa:841 CASP8; caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) hsa:595 CCND1; cyclin D1 hsa:998 CDC42; cell division cycle 42 hsa:1019 CDK4; cyclin-dependent kinase 4 (EC:2.7.11.22) hsa:1026 CDKN1A; cyclin-dependent kinase inhibitor 1A (p21, Cip1) hsa:1027 CDKN1B; cyclin-dependent kinase inhibitor 1B (p27, Kip1) hsa:1029 CDKN2A; cyclin-dependent kinase inhibitor 2A hsa:1385 CREB1; cAMP responsive element binding protein 1 hsa:9586 CREB5; cAMP responsive element binding protein 5 hsa:1959 EGR2; early growth response 2 hsa:2885 GRB2; growth factor receptor-bound protein 2 hsa:3106 HLA-B; major histocompatibility complex, class I, B hsa:3134 HLA-F; major histocompatibility complex, class I, F hsa:3190 HNRNPK; heterogeneous nuclear ribonucleoprotein K hsa:8517 IKBKG; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma hsa:3572 IL6ST; interleukin 6 signal transducer (gp130, oncostatin M receptor) hsa:3718 JAK3; Janus kinase 3 (EC:2.7.10.2) hsa:3725 JUN; jun proto-oncogene hsa:3845 KRAS; Kirsten rat sarcoma viral oncogene homolog hsa:4067 LYN; v-yes-1 Yamaguchi sarcoma viral related oncogene homolog (EC:2.7.10.2) hsa:5594 MAPK1; mitogen-activated protein kinase 1 (EC:2.7.11.24) hsa:5595 MAPK3; mitogen-activated protein kinase 3 (EC:2.7.11.24) hsa:4193 MDM2; MDM2 oncogene, E3 ubiquitin protein ligase hsa:4790 NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 hsa:4792 NFKBIA; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha hsa:4893 NRAS; neuroblastoma RAS viral (v-ras) oncogene homolog hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha) hsa:5366 PMAIP1; phorbol-12-myristate-13-acetate-induced protein 1 hsa:5829 PXN; paxillin hsa:5879 RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) hsa:5933 RBL1; retinoblastoma-like 1 (p107) hsa:5934 RBL2; retinoblastoma-like 2 (p130) hsa:5966 REL; v-rel avian reticuloendotheliosis viral oncogene homolog hsa:5970 RELA; v-rel avian reticuloendotheliosis viral oncogene homolog A hsa:387 RHOA; ras homolog family member A hsa:6502 SKP2; S-phase kinase-associated protein 2, E3 ubiquitin protein ligase hsa:6714 SRC; v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (EC:2.7.10.2) hsa:6722 SRF; serum response factor (c-fos serum response element-binding transcription factor) hsa:6774 STAT3; signal transducer and activator of transcription 3 (acute-phase response factor) hsa:6776 STAT5A; signal transducer and activator of transcription 5A hsa:6777 STAT5B; signal transducer and activator of transcription 5B hsa:6850 SYK; spleen tyrosine kinase (EC:2.7.10.2) hsa:7157 TP53; tumor protein p53 hsa:8717 TRADD; TNFRSF1A-associated via death domain hsa:7874 USP7; ubiquitin specific peptidase 7 (herpes virus-associated) (EC:3.4.19.12) hsa:7529 YWHAB; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide hsa:10971 YWHAQ; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide

hsa04620 Toll-like receptor signaling pathway - Homo sapiens (human) (51)

hsa:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) hsa:841 CASP8; caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) hsa:6348 CCL3; chemokine (C-C motif) ligand 3 hsa:6351 CCL4; chemokine (C-C motif) ligand 4 hsa:6352 CCL5; chemokine (C-C motif) ligand 5 hsa:929 CD14; CD14 molecule hsa:1147 CHUK; conserved helix-loop-helix ubiquitous kinase (EC:2.7.11.10) hsa:3627 CXCL10; chemokine (C-X-C motif) ligand 10 hsa:6373 CXCL11; chemokine (C-X-C motif) ligand 11 hsa:4283 CXCL9; chemokine (C-X-C motif) ligand 9 hsa:2353 FOS; FBJ murine osteosarcoma viral oncogene homolog hsa:3439 IFNA1; interferon, alpha 1 hsa:3445 IFNA8; interferon, alpha 8 hsa:3454 IFNAR1; interferon (alpha, beta and omega) receptor 1 hsa:3455 IFNAR2; interferon (alpha, beta and omega) receptor 2 hsa:3551 IKBKB; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta (EC:2.7.11.10) hsa:9641 IKBKE; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon (EC:2.7.11.10) hsa:8517 IKBKG; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma hsa:3553 IL1B; interleukin 1, beta hsa:3569 IL6; interleukin 6 (interferon, beta 2) hsa:3576 IL8; interleukin 8 hsa:3654 IRAK1; interleukin-1 receptor-associated kinase 1 (EC:2.7.11.1) hsa:3663 IRF5; interferon regulatory factor 5 hsa:3725 JUN; jun proto-oncogene hsa:3929 LBP; lipopolysaccharide binding protein hsa:23643 LY96; lymphocyte antigen 96 hsa:5604 MAP2K1; mitogen-activated protein kinase kinase 1 (EC:2.7.12.2) hsa:5606 MAP2K3; mitogen-activated protein kinase kinase 3 (EC:2.7.12.2) hsa:6416 MAP2K4; mitogen-activated protein kinase kinase 4 (EC:2.7.12.2) hsa:6885 MAP3K7; mitogen-activated protein kinase kinase kinase 7 (EC:2.7.11.25) hsa:5594 MAPK1; mitogen-activated protein kinase 1 (EC:2.7.11.24) hsa:1432 MAPK14; mitogen-activated protein kinase 14 (EC:2.7.11.24) hsa:5595 MAPK3; mitogen-activated protein kinase 3 (EC:2.7.11.24) hsa:5599 MAPK8; mitogen-activated protein kinase 8 (EC:2.7.11.24) hsa:4790 NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 hsa:4792 NFKBIA; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha) hsa:5879 RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) hsa:5970 RELA; v-rel avian reticuloendotheliosis viral oncogene homolog A hsa:6772 STAT1; signal transducer and activator of transcription 1, 91kDa hsa:148022 TICAM1; toll-like receptor adaptor molecule 1 hsa:7096 TLR1; toll-like receptor 1 hsa:7097 TLR2; toll-like receptor 2 hsa:7098 TLR3; toll-like receptor 3 hsa:7099 TLR4; toll-like receptor 4 hsa:7100 TLR5; toll-like receptor 5 hsa:10333 TLR6; toll-like receptor 6 hsa:51284 TLR7; toll-like receptor 7 hsa:54106 TLR9; toll-like receptor 9 hsa:7124 TNF; tumor necrosis factor hsa:7189 TRAF6; TNF receptor-associated factor 6, E3 ubiquitin protein ligase

hsa04630 Jak-STAT signaling pathway - Homo sapiens (human) (51)

hsa:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) hsa:598 BCL2L1; BCL2-like 1 hsa:595 CCND1; cyclin D1 hsa:1437 CSF2; colony stimulating factor 2 (granulocyte-macrophage) hsa:1439 CSF2RB; colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) hsa:1441 CSF3R; colony stimulating factor 3 receptor (granulocyte) hsa:2885 GRB2; growth factor receptor-bound protein 2 hsa:3439 IFNA1; interferon, alpha 1 hsa:3445 IFNA8; interferon, alpha 8 hsa:3454 IFNAR1; interferon (alpha, beta and omega) receptor 1 hsa:3455 IFNAR2; interferon (alpha, beta and omega) receptor 2 hsa:3458 IFNG; interferon, gamma hsa:3459 IFNGR1; interferon gamma receptor 1 hsa:3586 IL10; interleukin 10 hsa:3587 IL10RA; interleukin 10 receptor, alpha hsa:3589 IL11; interleukin 11 hsa:3596 IL13; interleukin 13 hsa:3558 IL2; interleukin 2 hsa:51561 IL23A; interleukin 23, alpha subunit p19 hsa:3559 IL2RA; interleukin 2 receptor, alpha hsa:3560 IL2RB; interleukin 2 receptor, beta hsa:3561 IL2RG; interleukin 2 receptor, gamma hsa:3562 IL3; interleukin 3 (colony-stimulating factor, multiple) hsa:3563 IL3RA; interleukin 3 receptor, alpha (low affinity) hsa:3565 IL4; interleukin 4 hsa:3566 IL4R; interleukin 4 receptor hsa:3569 IL6; interleukin 6 (interferon, beta 2) hsa:3572 IL6ST; interleukin 6 signal transducer (gp130, oncostatin M receptor) hsa:3574 IL7; interleukin 7 hsa:3575 IL7R; interleukin 7 receptor hsa:3581 IL9R; interleukin 9 receptor hsa:3717 JAK2; Janus kinase 2 (EC:2.7.10.2) hsa:3718 JAK3; Janus kinase 3 (EC:2.7.10.2) hsa:3952 LEP; leptin hsa:3976 LIF; leukemia inhibitory factor hsa:4609 MYC; v-myc avian myelocytomatosis viral oncogene homolog hsa:5008 OSM; oncostatin M hsa:9180 OSMR; oncostatin M receptor hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha) hsa:5781 PTPN11; protein tyrosine phosphatase, non-receptor type 11 (EC:3.1.3.48) hsa:5777 PTPN6; protein tyrosine phosphatase, non-receptor type 6 (EC:3.1.3.48) hsa:8835 SOCS2; suppressor of cytokine signaling 2 hsa:6654 SOS1; son of sevenless homolog 1 (Drosophila) hsa:6772 STAT1; signal transducer and activator of transcription 1, 91kDa hsa:6773 STAT2; signal transducer and activator of transcription 2, 113kDa hsa:6774 STAT3; signal transducer and activator of transcription 3 (acute-phase response factor) hsa:6776 STAT5A; signal transducer and activator of transcription 5A hsa:6777 STAT5B; signal transducer and activator of transcription 5B hsa:6778 STAT6; signal transducer and activator of transcription 6, interleukin-4 induced hsa:7173 TPO; thyroid peroxidase (EC:1.11.1.8) hsa:85480 TSLP; thymic stromal lymphopoietin

hsa04380 Osteoclast differentiation - Homo sapiens (human) (50)

cpd:C00027 Hydrogen peroxide hsa:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) hsa:29760 BLNK; B-cell linker hsa:695 BTK; Bruton agammaglobulinemia tyrosine kinase (EC:2.7.10.2) hsa:1147 CHUK; conserved helix-loop-helix ubiquitous kinase (EC:2.7.11.10) hsa:1385 CREB1; cAMP responsive element binding protein 1 hsa:1536 CYBB; cytochrome b-245, beta polypeptide hsa:2353 FOS; FBJ murine osteosarcoma viral oncogene homolog hsa:8061 FOSL1; FOS-like antigen 1 hsa:2534 FYN; FYN oncogene related to SRC, FGR, YES (EC:2.7.10.2) hsa:2885 GRB2; growth factor receptor-bound protein 2 hsa:3454 IFNAR1; interferon (alpha, beta and omega) receptor 1 hsa:3455 IFNAR2; interferon (alpha, beta and omega) receptor 2 hsa:3458 IFNG; interferon, gamma hsa:3459 IFNGR1; interferon gamma receptor 1 hsa:3551 IKBKB; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta (EC:2.7.11.10) hsa:8517 IKBKG; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma hsa:3552 IL1A; interleukin 1, alpha hsa:3553 IL1B; interleukin 1, beta hsa:3554 IL1R1; interleukin 1 receptor, type I hsa:3725 JUN; jun proto-oncogene hsa:3726 JUNB; jun B proto-oncogene hsa:3727 JUND; jun D proto-oncogene hsa:3932 LCK; lymphocyte-specific protein tyrosine kinase (EC:2.7.10.2) hsa:3937 LCP2; lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) hsa:5604 MAP2K1; mitogen-activated protein kinase kinase 1 (EC:2.7.12.2) hsa:9020 MAP3K14; mitogen-activated protein kinase kinase kinase 14 (EC:2.7.11.25) hsa:6885 MAP3K7; mitogen-activated protein kinase kinase kinase 7 (EC:2.7.11.25) hsa:5594 MAPK1; mitogen-activated protein kinase 1 (EC:2.7.11.24) hsa:1432 MAPK14; mitogen-activated protein kinase 14 (EC:2.7.11.24) hsa:5595 MAPK3; mitogen-activated protein kinase 3 (EC:2.7.11.24) hsa:5599 MAPK8; mitogen-activated protein kinase 8 (EC:2.7.11.24) hsa:4790 NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 hsa:4792 NFKBIA; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha hsa:27035 NOX1; NADPH oxidase 1 hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha) hsa:5468 PPARG; peroxisome proliferator-activated receptor gamma hsa:5530 PPP3CA; protein phosphatase 3, catalytic subunit, alpha isozyme (EC:3.1.3.16) hsa:5879 RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) hsa:5970 RELA; v-rel avian reticuloendotheliosis viral oncogene homolog A hsa:6772 STAT1; signal transducer and activator of transcription 1, 91kDa hsa:6773 STAT2; signal transducer and activator of transcription 2, 113kDa hsa:6850 SYK; spleen tyrosine kinase (EC:2.7.10.2) hsa:7040 TGFB1; transforming growth factor, beta 1 hsa:7042 TGFB2; transforming growth factor, beta 2 hsa:7124 TNF; tumor necrosis factor hsa:7132 TNFRSF1A; tumor necrosis factor receptor superfamily, member 1A hsa:8600 TNFSF11; tumor necrosis factor (ligand) superfamily, member 11 hsa:7189 TRAF6; TNF receptor-associated factor 6, E3 ubiquitin protein ligase hsa:54209 TREM2; triggering receptor expressed on myeloid cells 2

hsa05215 Prostate cancer - Homo sapiens (human) (50)

cpd:C00280 Androstenedione cpd:C00951 Estradiol-17beta cpd:C01227 Dehydroepiandrosterone hsa:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) hsa:572 BAD; BCL2-associated agonist of cell death hsa:596 BCL2; B-cell CLL/lymphoma 2 hsa:673 BRAF; v-raf murine sarcoma viral oncogene homolog B (EC:2.7.11.1) hsa:842 CASP9; caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) hsa:595 CCND1; cyclin D1 hsa:1026 CDKN1A; cyclin-dependent kinase inhibitor 1A (p21, Cip1) hsa:1027 CDKN1B; cyclin-dependent kinase inhibitor 1B (p27, Kip1) hsa:1147 CHUK; conserved helix-loop-helix ubiquitous kinase (EC:2.7.11.10) hsa:1385 CREB1; cAMP responsive element binding protein 1 hsa:9586 CREB5; cAMP responsive element binding protein 5 hsa:1499 CTNNB1; catenin (cadherin-associated protein), beta 1, 88kDa hsa:1869 E2F1; E2F transcription factor 1 hsa:1870 E2F2; E2F transcription factor 2 hsa:1950 EGF; epidermal growth factor hsa:1956 EGFR; epidermal growth factor receptor (EC:2.7.10.1) hsa:2064 ERBB2; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (EC:2.7.10.1) hsa:2263 FGFR2; fibroblast growth factor receptor 2 (EC:2.7.10.1) hsa:2308 FOXO1; forkhead box O1 hsa:2885 GRB2; growth factor receptor-bound protein 2 hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26) hsa:2950 GSTP1; glutathione S-transferase pi 1 (EC:2.5.1.18) hsa:3320 HSP90AA1; heat shock protein 90kDa alpha (cytosolic), class A member 1 hsa:3326 HSP90AB1; heat shock protein 90kDa alpha (cytosolic), class B member 1 hsa:7184 HSP90B1; heat shock protein 90kDa beta (Grp94), member 1 hsa:3479 IGF1; insulin-like growth factor 1 (somatomedin C) hsa:3551 IKBKB; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta (EC:2.7.11.10) hsa:8517 IKBKG; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma hsa:354 KLK3; kallikrein-related peptidase 3 (EC:3.4.21.77) hsa:3845 KRAS; Kirsten rat sarcoma viral oncogene homolog hsa:51176 LEF1; lymphoid enhancer-binding factor 1 hsa:5604 MAP2K1; mitogen-activated protein kinase kinase 1 (EC:2.7.12.2) hsa:5594 MAPK1; mitogen-activated protein kinase 1 (EC:2.7.11.24) hsa:5595 MAPK3; mitogen-activated protein kinase 3 (EC:2.7.11.24) hsa:4193 MDM2; MDM2 oncogene, E3 ubiquitin protein ligase hsa:4790 NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 hsa:4792 NFKBIA; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha hsa:4893 NRAS; neuroblastoma RAS viral (v-ras) oncogene homolog hsa:5154 PDGFA; platelet-derived growth factor alpha polypeptide hsa:5155 PDGFB; platelet-derived growth factor beta polypeptide hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha) hsa:5728 PTEN; phosphatase and tensin homolog (EC:3.1.3.67 3.1.3.16 3.1.3.48) hsa:5894 RAF1; v-raf-1 murine leukemia viral oncogene homolog 1 (EC:2.7.11.1) hsa:5970 RELA; v-rel avian reticuloendotheliosis viral oncogene homolog A hsa:6654 SOS1; son of sevenless homolog 1 (Drosophila) hsa:7039 TGFA; transforming growth factor, alpha hsa:7157 TP53; tumor protein p53

hsa05142 Chagas disease (American trypanosomiasis) - Homo sapiens (human) (49)

cpd:C00062 L-Arginine cpd:C00533 Nitric oxide hsa:1636 ACE; angiotensin I converting enzyme (EC:3.4.15.1) hsa:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) hsa:713 C1QB; complement component 1, q subcomponent, B chain hsa:718 C3; complement component 3 (EC:3.4.21.43) hsa:841 CASP8; caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) hsa:6347 CCL2; chemokine (C-C motif) ligand 2 hsa:6348 CCL3; chemokine (C-C motif) ligand 3 hsa:6352 CCL5; chemokine (C-C motif) ligand 5 hsa:915 CD3D; CD3d molecule, delta (CD3-TCR complex) hsa:1147 CHUK; conserved helix-loop-helix ubiquitous kinase (EC:2.7.11.10) hsa:355 FAS; Fas cell surface death receptor hsa:2353 FOS; FBJ murine osteosarcoma viral oncogene homolog hsa:2778 GNAS; GNAS complex locus hsa:3458 IFNG; interferon, gamma hsa:3459 IFNGR1; interferon gamma receptor 1 hsa:3551 IKBKB; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta (EC:2.7.11.10) hsa:8517 IKBKG; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma hsa:3586 IL10; interleukin 10 hsa:3553 IL1B; interleukin 1, beta hsa:3558 IL2; interleukin 2 hsa:3569 IL6; interleukin 6 (interferon, beta 2) hsa:3576 IL8; interleukin 8 hsa:3654 IRAK1; interleukin-1 receptor-associated kinase 1 (EC:2.7.11.1) hsa:3725 JUN; jun proto-oncogene hsa:6416 MAP2K4; mitogen-activated protein kinase kinase 4 (EC:2.7.12.2) hsa:5594 MAPK1; mitogen-activated protein kinase 1 (EC:2.7.11.24) hsa:1432 MAPK14; mitogen-activated protein kinase 14 (EC:2.7.11.24) hsa:5595 MAPK3; mitogen-activated protein kinase 3 (EC:2.7.11.24) hsa:5599 MAPK8; mitogen-activated protein kinase 8 (EC:2.7.11.24) hsa:4790 NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 hsa:4792 NFKBIA; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha hsa:4843 NOS2; nitric oxide synthase 2, inducible (EC:1.14.13.39) hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha) hsa:5330 PLCB2; phospholipase C, beta 2 (EC:3.1.4.11) hsa:5332 PLCB4; phospholipase C, beta 4 (EC:3.1.4.11) hsa:5970 RELA; v-rel avian reticuloendotheliosis viral oncogene homolog A hsa:5054 SERPINE1; serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 hsa:7040 TGFB1; transforming growth factor, beta 1 hsa:7042 TGFB2; transforming growth factor, beta 2 hsa:148022 TICAM1; toll-like receptor adaptor molecule 1 hsa:7097 TLR2; toll-like receptor 2 hsa:7099 TLR4; toll-like receptor 4 hsa:10333 TLR6; toll-like receptor 6 hsa:54106 TLR9; toll-like receptor 9 hsa:7124 TNF; tumor necrosis factor hsa:7132 TNFRSF1A; tumor necrosis factor receptor superfamily, member 1A hsa:7189 TRAF6; TNF receptor-associated factor 6, E3 ubiquitin protein ligase

hsa05160 Hepatitis C - Homo sapiens (human) (49)

cpd:C00027 Hydrogen peroxide hsa:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) hsa:572 BAD; BCL2-associated agonist of cell death hsa:673 BRAF; v-raf murine sarcoma viral oncogene homolog B (EC:2.7.11.1) hsa:1026 CDKN1A; cyclin-dependent kinase inhibitor 1A (p21, Cip1) hsa:1147 CHUK; conserved helix-loop-helix ubiquitous kinase (EC:2.7.11.10) hsa:53842 CLDN22; claudin 22 hsa:1364 CLDN4; claudin 4 hsa:7122 CLDN5; claudin 5 hsa:23586 DDX58; DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 (EC:3.6.4.13) hsa:1950 EGF; epidermal growth factor hsa:1956 EGFR; epidermal growth factor receptor (EC:2.7.10.1) hsa:2885 GRB2; growth factor receptor-bound protein 2 hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26) hsa:3434 IFIT1; interferon-induced protein with tetratricopeptide repeats 1 hsa:3439 IFNA1; interferon, alpha 1 hsa:3445 IFNA8; interferon, alpha 8 hsa:3454 IFNAR1; interferon (alpha, beta and omega) receptor 1 hsa:3455 IFNAR2; interferon (alpha, beta and omega) receptor 2 hsa:3551 IKBKB; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta (EC:2.7.11.10) hsa:9641 IKBKE; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon (EC:2.7.11.10) hsa:8517 IKBKG; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma hsa:3576 IL8; interleukin 8 hsa:3845 KRAS; Kirsten rat sarcoma viral oncogene homolog hsa:3949 LDLR; low density lipoprotein receptor hsa:5594 MAPK1; mitogen-activated protein kinase 1 (EC:2.7.11.24) hsa:1432 MAPK14; mitogen-activated protein kinase 14 (EC:2.7.11.24) hsa:5595 MAPK3; mitogen-activated protein kinase 3 (EC:2.7.11.24) hsa:5599 MAPK8; mitogen-activated protein kinase 8 (EC:2.7.11.24) hsa:4790 NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 hsa:4792 NFKBIA; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha hsa:4893 NRAS; neuroblastoma RAS viral (v-ras) oncogene homolog hsa:4938 OAS1; 2'-5'-oligoadenylate synthetase 1, 40/46kDa (EC:2.7.7.84) hsa:4939 OAS2; 2'-5'-oligoadenylate synthetase 2, 69/71kDa (EC:2.7.7.84) hsa:100506658 OCLN; occludin (EC:2.1.1.67) hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha) hsa:5894 RAF1; v-raf-1 murine leukemia viral oncogene homolog 1 (EC:2.7.11.1) hsa:5970 RELA; v-rel avian reticuloendotheliosis viral oncogene homolog A hsa:6654 SOS1; son of sevenless homolog 1 (Drosophila) hsa:6772 STAT1; signal transducer and activator of transcription 1, 91kDa hsa:6773 STAT2; signal transducer and activator of transcription 2, 113kDa hsa:6774 STAT3; signal transducer and activator of transcription 3 (acute-phase response factor) hsa:148022 TICAM1; toll-like receptor adaptor molecule 1 hsa:7098 TLR3; toll-like receptor 3 hsa:7124 TNF; tumor necrosis factor hsa:7132 TNFRSF1A; tumor necrosis factor receptor superfamily, member 1A hsa:7157 TP53; tumor protein p53 hsa:8717 TRADD; TNFRSF1A-associated via death domain hsa:7189 TRAF6; TNF receptor-associated factor 6, E3 ubiquitin protein ligase

hsa05010 Alzheimer's disease - Homo sapiens (human) (46) Positive association between H.Pylori infection and Alzheimer's disease in several studies Pubmed

cpd:C00027 Hydrogen peroxide cpd:C00533 Nitric oxide cpd:C16845 Peroxynitrite hsa:102 ADAM10; ADAM metallopeptidase domain 10 (EC:3.4.24.81) hsa:6868 ADAM17; ADAM metallopeptidase domain 17 (EC:3.4.24.86) hsa:348 APOE; apolipoprotein E hsa:22926 ATF6; activating transcription factor 6 hsa:517 ATP5G2; ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9) hsa:572 BAD; BCL2-associated agonist of cell death hsa:637 BID; BH3 interacting domain death agonist hsa:823 CAPN1; calpain 1, (mu/I) large subunit (EC:3.4.22.52) hsa:836 CASP3; caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) hsa:840 CASP7; caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) hsa:841 CASP8; caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) hsa:842 CASP9; caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) hsa:1020 CDK5; cyclin-dependent kinase 5 (EC:2.7.11.22) hsa:4512 COX1; cytochrome c oxidase subunit I hsa:54205 CYCS; cytochrome c, somatic hsa:355 FAS; Fas cell surface death receptor hsa:2902 GRIN1; glutamate receptor, ionotropic, N-methyl D-aspartate 1 hsa:2903 GRIN2A; glutamate receptor, ionotropic, N-methyl D-aspartate 2A hsa:2904 GRIN2B; glutamate receptor, ionotropic, N-methyl D-aspartate 2B hsa:2905 GRIN2C; glutamate receptor, ionotropic, N-methyl D-aspartate 2C hsa:2906 GRIN2D; glutamate receptor, ionotropic, N-methyl D-aspartate 2D hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26) hsa:3553 IL1B; interleukin 1, beta hsa:3709 ITPR2; inositol 1,4,5-trisphosphate receptor, type 2 hsa:4035 LRP1; low density lipoprotein receptor-related protein 1 hsa:5594 MAPK1; mitogen-activated protein kinase 1 (EC:2.7.11.24) hsa:5595 MAPK3; mitogen-activated protein kinase 3 (EC:2.7.11.24) hsa:4137 MAPT; microtubule-associated protein tau hsa:4697 NDUFA4; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4, 9kDa (EC:1.6.5.3 1.6.99.3) hsa:4725 NDUFS5; NADH dehydrogenase (ubiquinone) Fe-S protein 5, 15kDa (NADH-coenzyme Q reductase) hsa:4729 NDUFV2; NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa (EC:1.6.5.3 1.6.99.3) hsa:4842 NOS1; nitric oxide synthase 1 (neuronal) (EC:1.14.13.39) hsa:5330 PLCB2; phospholipase C, beta 2 (EC:3.1.4.11) hsa:5332 PLCB4; phospholipase C, beta 4 (EC:3.1.4.11) hsa:5530 PPP3CA; protein phosphatase 3, catalytic subunit, alpha isozyme (EC:3.1.3.16) hsa:5663 PSEN1; presenilin 1 (EC:3.4.23.-) hsa:6263 RYR3; ryanodine receptor 3 hsa:6389 SDHA; succinate dehydrogenase complex, subunit A, flavoprotein (Fp) (EC:1.3.5.1) hsa:6390 SDHB; succinate dehydrogenase complex, subunit B, iron sulfur (Ip) (EC:1.3.5.1) hsa:6391 SDHC; succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa hsa:6392 SDHD; succinate dehydrogenase complex, subunit D, integral membrane protein hsa:7124 TNF; tumor necrosis factor hsa:7132 TNFRSF1A; tumor necrosis factor receptor superfamily, member 1A

hsa04064 NF-kappa B signaling pathway - Homo sapiens (human) (45)

hsa:472 ATM; ataxia telangiectasia mutated (EC:2.7.11.1) hsa:596 BCL2; B-cell CLL/lymphoma 2 hsa:598 BCL2L1; BCL2-like 1 hsa:329 BIRC2; baculoviral IAP repeat containing 2 hsa:330 BIRC3; baculoviral IAP repeat containing 3 hsa:29760 BLNK; B-cell linker hsa:695 BTK; Bruton agammaglobulinemia tyrosine kinase (EC:2.7.10.2) hsa:6363 CCL19; chemokine (C-C motif) ligand 19 hsa:6351 CCL4; chemokine (C-C motif) ligand 4 hsa:929 CD14; CD14 molecule hsa:1147 CHUK; conserved helix-loop-helix ubiquitous kinase (EC:2.7.11.10) hsa:1457 CSNK2A1; casein kinase 2, alpha 1 polypeptide (EC:2.7.11.1) hsa:2920 CXCL2; chemokine (C-X-C motif) ligand 2 hsa:23586 DDX58; DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 (EC:3.6.4.13) hsa:3383 ICAM1; intercellular adhesion molecule 1 hsa:3551 IKBKB; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta (EC:2.7.11.10) hsa:8517 IKBKG; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma hsa:3553 IL1B; interleukin 1, beta hsa:3554 IL1R1; interleukin 1 receptor, type I hsa:3576 IL8; interleukin 8 hsa:3654 IRAK1; interleukin-1 receptor-associated kinase 1 (EC:2.7.11.1) hsa:3929 LBP; lipopolysaccharide binding protein hsa:3932 LCK; lymphocyte-specific protein tyrosine kinase (EC:2.7.10.2) hsa:23643 LY96; lymphocyte antigen 96 hsa:4067 LYN; v-yes-1 Yamaguchi sarcoma viral related oncogene homolog (EC:2.7.10.2) hsa:9020 MAP3K14; mitogen-activated protein kinase kinase kinase 14 (EC:2.7.11.25) hsa:6885 MAP3K7; mitogen-activated protein kinase kinase kinase 7 (EC:2.7.11.25) hsa:4790 NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 hsa:4792 NFKBIA; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha hsa:142 PARP1; poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) hsa:5328 PLAU; plasminogen activator, urokinase (EC:3.4.21.73) hsa:5335 PLCG1; phospholipase C, gamma 1 (EC:3.1.4.11) hsa:5588 PRKCQ; protein kinase C, theta (EC:2.7.11.13) hsa:5743 PTGS2; prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) hsa:5970 RELA; v-rel avian reticuloendotheliosis viral oncogene homolog A hsa:6850 SYK; spleen tyrosine kinase (EC:2.7.10.2) hsa:148022 TICAM1; toll-like receptor adaptor molecule 1 hsa:7099 TLR4; toll-like receptor 4 hsa:7124 TNF; tumor necrosis factor hsa:7132 TNFRSF1A; tumor necrosis factor receptor superfamily, member 1A hsa:8600 TNFSF11; tumor necrosis factor (ligand) superfamily, member 11 hsa:10673 TNFSF13B; tumor necrosis factor (ligand) superfamily, member 13b hsa:8717 TRADD; TNFRSF1A-associated via death domain hsa:7189 TRAF6; TNF receptor-associated factor 6, E3 ubiquitin protein ligase hsa:7412 VCAM1; vascular cell adhesion molecule 1

hsa05120 Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human) (44)

cpd:C00014 Ammonia cpd:C00080 H+ cpd:C00086 Urea cpd:C00698 Cl- cpd:C01342 NH4+ hsa:102 ADAM10; ADAM metallopeptidase domain 10 (EC:3.4.24.81) hsa:6868 ADAM17; ADAM metallopeptidase domain 17 (EC:3.4.24.86) hsa:533 ATP6V0B; ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b (EC:3.6.3.14) hsa:525 ATP6V1B1; ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1 (EC:3.6.3.14) hsa:9296 ATP6V1F; ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F (EC:3.6.3.14) hsa:9550 ATP6V1G1; ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1 (EC:3.6.3.14) hsa:836 CASP3; caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) hsa:6352 CCL5; chemokine (C-C motif) ligand 5 hsa:998 CDC42; cell division cycle 42 hsa:1147 CHUK; conserved helix-loop-helix ubiquitous kinase (EC:2.7.11.10) hsa:1445 CSK; c-src tyrosine kinase (EC:2.7.10.2) hsa:2919 CXCL1; chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) hsa:3579 CXCR2; chemokine (C-X-C motif) receptor 2 hsa:1956 EGFR; epidermal growth factor receptor (EC:2.7.10.1) hsa:50848 F11R; F11 receptor hsa:28964 GIT1; G protein-coupled receptor kinase interacting ArfGAP 1 hsa:1839 HBEGF; heparin-binding EGF-like growth factor hsa:3551 IKBKB; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta (EC:2.7.11.10) hsa:8517 IKBKG; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma hsa:3576 IL8; interleukin 8 hsa:3725 JUN; jun proto-oncogene hsa:4067 LYN; v-yes-1 Yamaguchi sarcoma viral related oncogene homolog (EC:2.7.10.2) hsa:6416 MAP2K4; mitogen-activated protein kinase kinase 4 (EC:2.7.12.2) hsa:9020 MAP3K14; mitogen-activated protein kinase kinase kinase 14 (EC:2.7.11.25) hsa:1432 MAPK14; mitogen-activated protein kinase 14 (EC:2.7.11.24) hsa:5599 MAPK8; mitogen-activated protein kinase 8 (EC:2.7.11.24) hsa:4233 MET; met proto-oncogene (EC:2.7.10.1) hsa:4790 NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 hsa:4792 NFKBIA; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha hsa:10392 NOD1; nucleotide-binding oligomerization domain containing 1 hsa:5058 PAK1; p21 protein (Cdc42/Rac)-activated kinase 1 (EC:2.7.11.1) hsa:5335 PLCG1; phospholipase C, gamma 1 (EC:3.1.4.11) hsa:5781 PTPN11; protein tyrosine phosphatase, non-receptor type 11 (EC:3.1.3.48) hsa:5803 PTPRZ1; protein tyrosine phosphatase, receptor-type, Z polypeptide 1 (EC:3.1.3.48) hsa:5879 RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) hsa:5970 RELA; v-rel avian reticuloendotheliosis viral oncogene homolog A hsa:6714 SRC; v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (EC:2.7.10.2) hsa:10312 TCIRG1; T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3 (EC:3.6.3.6) hsa:7082 TJP1; tight junction protein 1

hsa05323 Rheumatoid arthritis - Homo sapiens (human) (44)

cpd:C00080 H+ cpd:C00584 Prostaglandin E2 hsa:533 ATP6V0B; ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b (EC:3.6.3.14) hsa:525 ATP6V1B1; ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1 (EC:3.6.3.14) hsa:9296 ATP6V1F; ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F (EC:3.6.3.14) hsa:9550 ATP6V1G1; ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1 (EC:3.6.3.14) hsa:6347 CCL2; chemokine (C-C motif) ligand 2 hsa:6364 CCL20; chemokine (C-C motif) ligand 20 hsa:6348 CCL3; chemokine (C-C motif) ligand 3 hsa:6352 CCL5; chemokine (C-C motif) ligand 5 hsa:1437 CSF2; colony stimulating factor 2 (granulocyte-macrophage) hsa:1493 CTLA4; cytotoxic T-lymphocyte-associated protein 4 hsa:2919 CXCL1; chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) hsa:6374 CXCL5; chemokine (C-X-C motif) ligand 5 hsa:2353 FOS; FBJ murine osteosarcoma viral oncogene homolog hsa:3108 HLA-DMA; major histocompatibility complex, class II, DM alpha hsa:3117 HLA-DQA1; major histocompatibility complex, class II, DQ alpha 1 hsa:3119 HLA-DQB1; major histocompatibility complex, class II, DQ beta 1 hsa:3122 HLA-DRA; major histocompatibility complex, class II, DR alpha hsa:3125 HLA-DRB3; major histocompatibility complex, class II, DR beta 3 hsa:3127 HLA-DRB5; major histocompatibility complex, class II, DR beta 5 hsa:3383 ICAM1; intercellular adhesion molecule 1 hsa:3458 IFNG; interferon, gamma hsa:3589 IL11; interleukin 11 hsa:3605 IL17A; interleukin 17A hsa:3552 IL1A; interleukin 1, alpha hsa:3553 IL1B; interleukin 1, beta hsa:51561 IL23A; interleukin 23, alpha subunit p19 hsa:3569 IL6; interleukin 6 (interferon, beta 2) hsa:3576 IL8; interleukin 8 hsa:3683 ITGAL; integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) hsa:3689 ITGB2; integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) hsa:3725 JUN; jun proto-oncogene hsa:4312 MMP1; matrix metallopeptidase 1 (interstitial collagenase) (EC:3.4.24.7) hsa:10312 TCIRG1; T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3 (EC:3.6.3.6) hsa:7040 TGFB1; transforming growth factor, beta 1 hsa:7042 TGFB2; transforming growth factor, beta 2 hsa:7097 TLR2; toll-like receptor 2 hsa:7099 TLR4; toll-like receptor 4 hsa:7124 TNF; tumor necrosis factor hsa:8600 TNFSF11; tumor necrosis factor (ligand) superfamily, member 11 hsa:8741 TNFSF13; tumor necrosis factor (ligand) superfamily, member 13 hsa:10673 TNFSF13B; tumor necrosis factor (ligand) superfamily, member 13b hsa:7422 VEGFA; vascular endothelial growth factor A

hsa04660 T cell receptor signaling pathway - Homo sapiens (human) (44)

hsa:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) hsa:915 CD3D; CD3d molecule, delta (CD3-TCR complex) hsa:998 CDC42; cell division cycle 42 hsa:1019 CDK4; cyclin-dependent kinase 4 (EC:2.7.11.22) hsa:1147 CHUK; conserved helix-loop-helix ubiquitous kinase (EC:2.7.11.10) hsa:1437 CSF2; colony stimulating factor 2 (granulocyte-macrophage) hsa:1493 CTLA4; cytotoxic T-lymphocyte-associated protein 4 hsa:2353 FOS; FBJ murine osteosarcoma viral oncogene homolog hsa:2534 FYN; FYN oncogene related to SRC, FGR, YES (EC:2.7.10.2) hsa:2885 GRB2; growth factor receptor-bound protein 2 hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26) hsa:3458 IFNG; interferon, gamma hsa:3551 IKBKB; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta (EC:2.7.11.10) hsa:8517 IKBKG; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma hsa:3586 IL10; interleukin 10 hsa:3558 IL2; interleukin 2 hsa:3565 IL4; interleukin 4 hsa:3725 JUN; jun proto-oncogene hsa:3845 KRAS; Kirsten rat sarcoma viral oncogene homolog hsa:3932 LCK; lymphocyte-specific protein tyrosine kinase (EC:2.7.10.2) hsa:3937 LCP2; lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) hsa:5604 MAP2K1; mitogen-activated protein kinase kinase 1 (EC:2.7.12.2) hsa:9020 MAP3K14; mitogen-activated protein kinase kinase kinase 14 (EC:2.7.11.25) hsa:6885 MAP3K7; mitogen-activated protein kinase kinase kinase 7 (EC:2.7.11.25) hsa:5594 MAPK1; mitogen-activated protein kinase 1 (EC:2.7.11.24) hsa:1432 MAPK14; mitogen-activated protein kinase 14 (EC:2.7.11.24) hsa:5595 MAPK3; mitogen-activated protein kinase 3 (EC:2.7.11.24) hsa:4790 NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 hsa:4792 NFKBIA; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha hsa:4893 NRAS; neuroblastoma RAS viral (v-ras) oncogene homolog hsa:5058 PAK1; p21 protein (Cdc42/Rac)-activated kinase 1 (EC:2.7.11.1) hsa:5062 PAK2; p21 protein (Cdc42/Rac)-activated kinase 2 (EC:2.7.11.1) hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha) hsa:5335 PLCG1; phospholipase C, gamma 1 (EC:3.1.4.11) hsa:5530 PPP3CA; protein phosphatase 3, catalytic subunit, alpha isozyme (EC:3.1.3.16) hsa:5588 PRKCQ; protein kinase C, theta (EC:2.7.11.13) hsa:5777 PTPN6; protein tyrosine phosphatase, non-receptor type 6 (EC:3.1.3.48) hsa:5788 PTPRC; protein tyrosine phosphatase, receptor type, C (EC:3.1.3.48) hsa:5894 RAF1; v-raf-1 murine leukemia viral oncogene homolog 1 (EC:2.7.11.1) hsa:5970 RELA; v-rel avian reticuloendotheliosis viral oncogene homolog A hsa:387 RHOA; ras homolog family member A hsa:6654 SOS1; son of sevenless homolog 1 (Drosophila) hsa:7124 TNF; tumor necrosis factor hsa:7409 VAV1; vav 1 guanine nucleotide exchange factor

hsa05140 Leishmaniasis - Homo sapiens (human) (43)

cpd:C00195 N-Acylsphingosine cpd:C00533 Nitric oxide cpd:C00584 Prostaglandin E2 cpd:C02737 Phosphatidylserine hsa:718 C3; complement component 3 (EC:3.4.21.43) hsa:1378 CR1; complement component (3b/4b) receptor 1 (Knops blood group) hsa:2002 ELK1; ELK1, member of ETS oncogene family hsa:2353 FOS; FBJ murine osteosarcoma viral oncogene homolog hsa:3108 HLA-DMA; major histocompatibility complex, class II, DM alpha hsa:3117 HLA-DQA1; major histocompatibility complex, class II, DQ alpha 1 hsa:3119 HLA-DQB1; major histocompatibility complex, class II, DQ beta 1 hsa:3122 HLA-DRA; major histocompatibility complex, class II, DR alpha hsa:3125 HLA-DRB3; major histocompatibility complex, class II, DR beta 3 hsa:3127 HLA-DRB5; major histocompatibility complex, class II, DR beta 5 hsa:3458 IFNG; interferon, gamma hsa:3459 IFNGR1; interferon gamma receptor 1 hsa:3586 IL10; interleukin 10 hsa:3552 IL1A; interleukin 1, alpha hsa:3553 IL1B; interleukin 1, beta hsa:3565 IL4; interleukin 4 hsa:3654 IRAK1; interleukin-1 receptor-associated kinase 1 (EC:2.7.11.1) hsa:3684 ITGAM; integrin, alpha M (complement component 3 receptor 3 subunit) hsa:3688 ITGB1; integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) hsa:3689 ITGB2; integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) hsa:3717 JAK2; Janus kinase 2 (EC:2.7.10.2) hsa:3725 JUN; jun proto-oncogene hsa:6885 MAP3K7; mitogen-activated protein kinase kinase kinase 7 (EC:2.7.11.25) hsa:5594 MAPK1; mitogen-activated protein kinase 1 (EC:2.7.11.24) hsa:1432 MAPK14; mitogen-activated protein kinase 14 (EC:2.7.11.24) hsa:5595 MAPK3; mitogen-activated protein kinase 3 (EC:2.7.11.24) hsa:4790 NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 hsa:4792 NFKBIA; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha hsa:4843 NOS2; nitric oxide synthase 2, inducible (EC:1.14.13.39) hsa:5743 PTGS2; prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) hsa:5777 PTPN6; protein tyrosine phosphatase, non-receptor type 6 (EC:3.1.3.48) hsa:5970 RELA; v-rel avian reticuloendotheliosis viral oncogene homolog A hsa:6772 STAT1; signal transducer and activator of transcription 1, 91kDa hsa:7040 TGFB1; transforming growth factor, beta 1 hsa:7042 TGFB2; transforming growth factor, beta 2 hsa:7097 TLR2; toll-like receptor 2 hsa:7099 TLR4; toll-like receptor 4 hsa:7124 TNF; tumor necrosis factor hsa:7189 TRAF6; TNF receptor-associated factor 6, E3 ubiquitin protein ligase

hsa04722 Neurotrophin signaling pathway - Homo sapiens (human) (43)

cpd:C00195 N-Acylsphingosine hsa:25 ABL1; c-abl oncogene 1, non-receptor tyrosine kinase (EC:2.7.10.2) hsa:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) hsa:572 BAD; BCL2-associated agonist of cell death hsa:581 BAX; BCL2-associated X protein hsa:596 BCL2; B-cell CLL/lymphoma 2 hsa:673 BRAF; v-raf murine sarcoma viral oncogene homolog B (EC:2.7.11.1) hsa:998 CDC42; cell division cycle 42 hsa:1398 CRK; v-crk avian sarcoma virus CT10 oncogene homolog hsa:1399 CRKL; v-crk avian sarcoma virus CT10 oncogene homolog-like hsa:2549 GAB1; GRB2-associated binding protein 1 hsa:2885 GRB2; growth factor receptor-bound protein 2 hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26) hsa:3551 IKBKB; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta (EC:2.7.11.10) hsa:3654 IRAK1; interleukin-1 receptor-associated kinase 1 (EC:2.7.11.1) hsa:3667 IRS1; insulin receptor substrate 1 hsa:3725 JUN; jun proto-oncogene hsa:3845 KRAS; Kirsten rat sarcoma viral oncogene homolog hsa:5604 MAP2K1; mitogen-activated protein kinase kinase 1 (EC:2.7.12.2) hsa:4214 MAP3K1; mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase (EC:2.7.11.25) hsa:5594 MAPK1; mitogen-activated protein kinase 1 (EC:2.7.11.24) hsa:1432 MAPK14; mitogen-activated protein kinase 14 (EC:2.7.11.24) hsa:5595 MAPK3; mitogen-activated protein kinase 3 (EC:2.7.11.24) hsa:5599 MAPK8; mitogen-activated protein kinase 8 (EC:2.7.11.24) hsa:4790 NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 hsa:4792 NFKBIA; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha hsa:27018 NGFRAP1; nerve growth factor receptor (TNFRSF16) associated protein 1 hsa:4893 NRAS; neuroblastoma RAS viral (v-ras) oncogene homolog hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha) hsa:5335 PLCG1; phospholipase C, gamma 1 (EC:3.1.4.11) hsa:5580 PRKCD; protein kinase C, delta (EC:2.7.10.2 2.7.11.13) hsa:5663 PSEN1; presenilin 1 (EC:3.4.23.-) hsa:5781 PTPN11; protein tyrosine phosphatase, non-receptor type 11 (EC:3.1.3.48) hsa:5879 RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) hsa:5894 RAF1; v-raf-1 murine leukemia viral oncogene homolog 1 (EC:2.7.11.1) hsa:5906 RAP1A; RAP1A, member of RAS oncogene family hsa:5970 RELA; v-rel avian reticuloendotheliosis viral oncogene homolog A hsa:387 RHOA; ras homolog family member A hsa:9252 RPS6KA5; ribosomal protein S6 kinase, 90kDa, polypeptide 5 (EC:2.7.11.1) hsa:6654 SOS1; son of sevenless homolog 1 (Drosophila) hsa:7157 TP53; tumor protein p53 hsa:7161 TP73; tumor protein p73 hsa:7189 TRAF6; TNF receptor-associated factor 6, E3 ubiquitin protein ligase

hsa05146 Amoebiasis - Homo sapiens (human) (42)

cpd:C00027 Hydrogen peroxide cpd:C00062 L-Arginine cpd:C00533 Nitric oxide cpd:C00584 Prostaglandin E2 cpd:C02737 Phosphatidylserine hsa:383 ARG1; arginase 1 (EC:3.5.3.1) hsa:384 ARG2; arginase 2 (EC:3.5.3.1) hsa:731 C8A; complement component 8, alpha polypeptide hsa:836 CASP3; caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) hsa:929 CD14; CD14 molecule hsa:1437 CSF2; colony stimulating factor 2 (granulocyte-macrophage) hsa:2919 CXCL1; chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) hsa:2335 FN1; fibronectin 1 hsa:2778 GNAS; GNAS complex locus hsa:3458 IFNG; interferon, gamma hsa:3586 IL10; interleukin 10 hsa:3553 IL1B; interleukin 1, beta hsa:3554 IL1R1; interleukin 1 receptor, type I hsa:7850 IL1R2; interleukin 1 receptor, type II hsa:3569 IL6; interleukin 6 (interferon, beta 2) hsa:3576 IL8; interleukin 8 hsa:3684 ITGAM; integrin, alpha M (complement component 3 receptor 3 subunit) hsa:3689 ITGB2; integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) hsa:284217 LAMA1; laminin, alpha 1 hsa:3912 LAMB1; laminin, beta 1 hsa:3915 LAMC1; laminin, gamma 1 (formerly LAMB2) hsa:4583 MUC2; mucin 2, oligomeric mucus/gel-forming hsa:4790 NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 hsa:4843 NOS2; nitric oxide synthase 2, inducible (EC:1.14.13.39) hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha) hsa:5330 PLCB2; phospholipase C, beta 2 (EC:3.1.4.11) hsa:5332 PLCB4; phospholipase C, beta 4 (EC:3.1.4.11) hsa:5578 PRKCA; protein kinase C, alpha (EC:2.7.11.13) hsa:5747 PTK2; protein tyrosine kinase 2 (EC:2.7.10.2) hsa:5970 RELA; v-rel avian reticuloendotheliosis viral oncogene homolog A hsa:5055 SERPINB2; serpin peptidase inhibitor, clade B (ovalbumin), member 2 hsa:7040 TGFB1; transforming growth factor, beta 1 hsa:7042 TGFB2; transforming growth factor, beta 2 hsa:7097 TLR2; toll-like receptor 2 hsa:7099 TLR4; toll-like receptor 4 hsa:7124 TNF; tumor necrosis factor hsa:7414 VCL; vinculin

hsa05202 Transcriptional misregulation in cancer - Homo sapiens (human) (41)

hsa:472 ATM; ataxia telangiectasia mutated (EC:2.7.11.1) hsa:598 BCL2L1; BCL2-like 1 hsa:330 BIRC3; baculoviral IAP repeat containing 3 hsa:929 CD14; CD14 molecule hsa:1025 CDK9; cyclin-dependent kinase 9 (EC:2.7.11.23 2.7.11.22) hsa:1026 CDKN1A; cyclin-dependent kinase inhibitor 1A (p21, Cip1) hsa:1027 CDKN1B; cyclin-dependent kinase inhibitor 1B (p27, Kip1) hsa:1437 CSF2; colony stimulating factor 2 (granulocyte-macrophage) hsa:1649 DDIT3; DNA-damage-inducible transcript 3 hsa:1668 DEFA3; defensin, alpha 3, neutrophil-specific hsa:1848 DUSP6; dual specificity phosphatase 6 (EC:3.1.3.16 3.1.3.48) hsa:2120 ETV6; ets variant 6 hsa:2308 FOXO1; forkhead box O1 hsa:8356 HIST1H3J; histone cluster 1, H3j hsa:3398 ID2; inhibitor of DNA binding 2, dominant negative helix-loop-helix protein hsa:3479 IGF1; insulin-like growth factor 1 (somatomedin C) hsa:3486 IGFBP3; insulin-like growth factor binding protein 3 hsa:7850 IL1R2; interleukin 1 receptor, type II hsa:3560 IL2RB; interleukin 2 receptor, beta hsa:3562 IL3; interleukin 3 (colony-stimulating factor, multiple) hsa:3569 IL6; interleukin 6 (interferon, beta 2) hsa:3576 IL8; interleukin 8 hsa:3684 ITGAM; integrin, alpha M (complement component 3 receptor 3 subunit) hsa:4094 MAF; v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog hsa:4193 MDM2; MDM2 oncogene, E3 ubiquitin protein ligase hsa:4233 MET; met proto-oncogene (EC:2.7.10.1) hsa:4318 MMP9; matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) hsa:4353 MPO; myeloperoxidase (EC:1.11.2.2) hsa:4609 MYC; v-myc avian myelocytomatosis viral oncogene homolog hsa:4790 NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 hsa:5079 PAX5; paired box 5 hsa:5154 PDGFA; platelet-derived growth factor alpha polypeptide hsa:5327 PLAT; plasminogen activator, tissue (EC:3.4.21.68) hsa:5328 PLAU; plasminogen activator, urokinase (EC:3.4.21.73) hsa:5468 PPARG; peroxisome proliferator-activated receptor gamma hsa:5747 PTK2; protein tyrosine kinase 2 (EC:2.7.10.2) hsa:5966 REL; v-rel avian reticuloendotheliosis viral oncogene homolog hsa:5970 RELA; v-rel avian reticuloendotheliosis viral oncogene homolog A hsa:7157 TP53; tumor protein p53 hsa:7490 WT1; Wilms tumor 1 hsa:7709 ZBTB17; zinc finger and BTB domain containing 17

hsa04650 Natural killer cell mediated cytotoxicity - Homo sapiens (human) (40)

hsa:637 BID; BH3 interacting domain death agonist hsa:673 BRAF; v-raf murine sarcoma viral oncogene homolog B (EC:2.7.11.1) hsa:836 CASP3; caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) hsa:1437 CSF2; colony stimulating factor 2 (granulocyte-macrophage) hsa:355 FAS; Fas cell surface death receptor hsa:2534 FYN; FYN oncogene related to SRC, FGR, YES (EC:2.7.10.2) hsa:2885 GRB2; growth factor receptor-bound protein 2 hsa:3106 HLA-B; major histocompatibility complex, class I, B hsa:3383 ICAM1; intercellular adhesion molecule 1 hsa:3439 IFNA1; interferon, alpha 1 hsa:3445 IFNA8; interferon, alpha 8 hsa:3454 IFNAR1; interferon (alpha, beta and omega) receptor 1 hsa:3455 IFNAR2; interferon (alpha, beta and omega) receptor 2 hsa:3458 IFNG; interferon, gamma hsa:3459 IFNGR1; interferon gamma receptor 1 hsa:3683 ITGAL; integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) hsa:3689 ITGB2; integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) hsa:3806 KIR2DS1; killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 1 hsa:3845 KRAS; Kirsten rat sarcoma viral oncogene homolog hsa:3932 LCK; lymphocyte-specific protein tyrosine kinase (EC:2.7.10.2) hsa:3937 LCP2; lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) hsa:5604 MAP2K1; mitogen-activated protein kinase kinase 1 (EC:2.7.12.2) hsa:5594 MAPK1; mitogen-activated protein kinase 1 (EC:2.7.11.24) hsa:5595 MAPK3; mitogen-activated protein kinase 3 (EC:2.7.11.24) hsa:4277 MICB; MHC class I polypeptide-related sequence B hsa:4893 NRAS; neuroblastoma RAS viral (v-ras) oncogene homolog hsa:5058 PAK1; p21 protein (Cdc42/Rac)-activated kinase 1 (EC:2.7.11.1) hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha) hsa:5335 PLCG1; phospholipase C, gamma 1 (EC:3.1.4.11) hsa:5530 PPP3CA; protein phosphatase 3, catalytic subunit, alpha isozyme (EC:3.1.3.16) hsa:5578 PRKCA; protein kinase C, alpha (EC:2.7.11.13) hsa:5781 PTPN11; protein tyrosine phosphatase, non-receptor type 11 (EC:3.1.3.48) hsa:5777 PTPN6; protein tyrosine phosphatase, non-receptor type 6 (EC:3.1.3.48) hsa:5879 RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) hsa:5880 RAC2; ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) hsa:5894 RAF1; v-raf-1 murine leukemia viral oncogene homolog 1 (EC:2.7.11.1) hsa:6654 SOS1; son of sevenless homolog 1 (Drosophila) hsa:6850 SYK; spleen tyrosine kinase (EC:2.7.10.2) hsa:7124 TNF; tumor necrosis factor hsa:7409 VAV1; vav 1 guanine nucleotide exchange factor

hsa04145 Phagosome - Homo sapiens (human) (40)

cpd:C00007 Oxygen cpd:C00027 Hydrogen peroxide cpd:C00533 Nitric oxide hsa:533 ATP6V0B; ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b (EC:3.6.3.14) hsa:525 ATP6V1B1; ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1 (EC:3.6.3.14) hsa:9296 ATP6V1F; ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F (EC:3.6.3.14) hsa:9550 ATP6V1G1; ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1 (EC:3.6.3.14) hsa:718 C3; complement component 3 (EC:3.4.21.43) hsa:929 CD14; CD14 molecule hsa:30835 CD209; CD209 molecule hsa:948 CD36; CD36 molecule (thrombospondin receptor) hsa:1536 CYBB; cytochrome b-245, beta polypeptide hsa:3106 HLA-B; major histocompatibility complex, class I, B hsa:3108 HLA-DMA; major histocompatibility complex, class II, DM alpha hsa:3117 HLA-DQA1; major histocompatibility complex, class II, DQ alpha 1 hsa:3119 HLA-DQB1; major histocompatibility complex, class II, DQ beta 1 hsa:3122 HLA-DRA; major histocompatibility complex, class II, DR alpha hsa:3125 HLA-DRB3; major histocompatibility complex, class II, DR beta 3 hsa:3127 HLA-DRB5; major histocompatibility complex, class II, DR beta 5 hsa:3134 HLA-F; major histocompatibility complex, class I, F hsa:3673 ITGA2; integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) hsa:3678 ITGA5; integrin, alpha 5 (fibronectin receptor, alpha polypeptide) hsa:3684 ITGAM; integrin, alpha M (complement component 3 receptor 3 subunit) hsa:3688 ITGB1; integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) hsa:3689 ITGB2; integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) hsa:3916 LAMP1; lysosomal-associated membrane protein 1 hsa:3920 LAMP2; lysosomal-associated membrane protein 2 hsa:4153 MBL2; mannose-binding lectin (protein C) 2, soluble hsa:4353 MPO; myeloperoxidase (EC:1.11.2.2) hsa:4842 NOS1; nitric oxide synthase 1 (neuronal) (EC:1.14.13.39) hsa:27035 NOX1; NADPH oxidase 1 hsa:200576 PIKFYVE; phosphoinositide kinase, FYVE finger containing (EC:2.7.1.150) hsa:5879 RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) hsa:10312 TCIRG1; T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3 (EC:3.6.3.6) hsa:7057 THBS1; thrombospondin 1 hsa:7097 TLR2; toll-like receptor 2 hsa:7099 TLR4; toll-like receptor 4 hsa:10333 TLR6; toll-like receptor 6 hsa:10376 TUBA1B; tubulin, alpha 1b hsa:203068 TUBB; tubulin, beta class I

hsa04066 HIF-1 signaling pathway - Homo sapiens (human) (39)

cpd:C00007 Oxygen cpd:C00072 Ascorbate cpd:C00338 Lipopolysaccharide cpd:C00533 Nitric oxide hsa:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) hsa:226 ALDOA; aldolase A, fructose-bisphosphate (EC:4.1.2.13) hsa:285 ANGPT2; angiopoietin 2 hsa:596 BCL2; B-cell CLL/lymphoma 2 hsa:1026 CDKN1A; cyclin-dependent kinase inhibitor 1A (p21, Cip1) hsa:1027 CDKN1B; cyclin-dependent kinase inhibitor 1B (p27, Kip1) hsa:1536 CYBB; cytochrome b-245, beta polypeptide hsa:1950 EGF; epidermal growth factor hsa:1956 EGFR; epidermal growth factor receptor (EC:2.7.10.1) hsa:2023 ENO1; enolase 1, (alpha) (EC:4.2.1.11) hsa:2027 ENO3; enolase 3 (beta, muscle) (EC:4.2.1.11) hsa:2064 ERBB2; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (EC:2.7.10.1) hsa:3091 HIF1A; hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) hsa:3162 HMOX1; heme oxygenase (decycling) 1 (EC:1.14.99.3) hsa:3458 IFNG; interferon, gamma hsa:3459 IFNGR1; interferon gamma receptor 1 hsa:3479 IGF1; insulin-like growth factor 1 (somatomedin C) hsa:3569 IL6; interleukin 6 (interferon, beta 2) hsa:5604 MAP2K1; mitogen-activated protein kinase kinase 1 (EC:2.7.12.2) hsa:5594 MAPK1; mitogen-activated protein kinase 1 (EC:2.7.11.24) hsa:5595 MAPK3; mitogen-activated protein kinase 3 (EC:2.7.11.24) hsa:4790 NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 hsa:4843 NOS2; nitric oxide synthase 2, inducible (EC:1.14.13.39) hsa:27035 NOX1; NADPH oxidase 1 hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha) hsa:5335 PLCG1; phospholipase C, gamma 1 (EC:3.1.4.11) hsa:5578 PRKCA; protein kinase C, alpha (EC:2.7.11.13) hsa:5970 RELA; v-rel avian reticuloendotheliosis viral oncogene homolog A hsa:5054 SERPINE1; serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 hsa:6774 STAT3; signal transducer and activator of transcription 3 (acute-phase response factor) hsa:6923 TCEB2; transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B) hsa:7018 TF; transferrin hsa:7076 TIMP1; TIMP metallopeptidase inhibitor 1 hsa:7099 TLR4; toll-like receptor 4 hsa:7422 VEGFA; vascular endothelial growth factor A

hsa04012 ErbB signaling pathway - Homo sapiens (human) (38)

hsa:25 ABL1; c-abl oncogene 1, non-receptor tyrosine kinase (EC:2.7.10.2) hsa:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) hsa:374 AREG; amphiregulin hsa:572 BAD; BCL2-associated agonist of cell death hsa:673 BRAF; v-raf murine sarcoma viral oncogene homolog B (EC:2.7.11.1) hsa:1026 CDKN1A; cyclin-dependent kinase inhibitor 1A (p21, Cip1) hsa:1027 CDKN1B; cyclin-dependent kinase inhibitor 1B (p27, Kip1) hsa:1398 CRK; v-crk avian sarcoma virus CT10 oncogene homolog hsa:1399 CRKL; v-crk avian sarcoma virus CT10 oncogene homolog-like hsa:1950 EGF; epidermal growth factor hsa:1956 EGFR; epidermal growth factor receptor (EC:2.7.10.1) hsa:2002 ELK1; ELK1, member of ETS oncogene family hsa:2064 ERBB2; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (EC:2.7.10.1) hsa:2549 GAB1; GRB2-associated binding protein 1 hsa:2885 GRB2; growth factor receptor-bound protein 2 hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26) hsa:1839 HBEGF; heparin-binding EGF-like growth factor hsa:3725 JUN; jun proto-oncogene hsa:3845 KRAS; Kirsten rat sarcoma viral oncogene homolog hsa:5604 MAP2K1; mitogen-activated protein kinase kinase 1 (EC:2.7.12.2) hsa:6416 MAP2K4; mitogen-activated protein kinase kinase 4 (EC:2.7.12.2) hsa:5594 MAPK1; mitogen-activated protein kinase 1 (EC:2.7.11.24) hsa:5595 MAPK3; mitogen-activated protein kinase 3 (EC:2.7.11.24) hsa:5599 MAPK8; mitogen-activated protein kinase 8 (EC:2.7.11.24) hsa:4609 MYC; v-myc avian myelocytomatosis viral oncogene homolog hsa:4893 NRAS; neuroblastoma RAS viral (v-ras) oncogene homolog hsa:5058 PAK1; p21 protein (Cdc42/Rac)-activated kinase 1 (EC:2.7.11.1) hsa:5062 PAK2; p21 protein (Cdc42/Rac)-activated kinase 2 (EC:2.7.11.1) hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha) hsa:5335 PLCG1; phospholipase C, gamma 1 (EC:3.1.4.11) hsa:5578 PRKCA; protein kinase C, alpha (EC:2.7.11.13) hsa:5747 PTK2; protein tyrosine kinase 2 (EC:2.7.10.2) hsa:5894 RAF1; v-raf-1 murine leukemia viral oncogene homolog 1 (EC:2.7.11.1) hsa:6654 SOS1; son of sevenless homolog 1 (Drosophila) hsa:6714 SRC; v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (EC:2.7.10.2) hsa:6776 STAT5A; signal transducer and activator of transcription 5A hsa:6777 STAT5B; signal transducer and activator of transcription 5B hsa:7039 TGFA; transforming growth factor, alpha

hsa05133 Pertussis - Homo sapiens (human) (38)

cpd:C00338 Lipopolysaccharide cpd:C00374 Heparin hsa:713 C1QB; complement component 1, q subcomponent, B chain hsa:717 C2; complement component 2 (EC:3.4.21.43) hsa:718 C3; complement component 3 (EC:3.4.21.43) hsa:720 C4A; complement component 4A (Rodgers blood group) hsa:836 CASP3; caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) hsa:840 CASP7; caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) hsa:929 CD14; CD14 molecule hsa:6374 CXCL5; chemokine (C-X-C motif) ligand 5 hsa:2353 FOS; FBJ murine osteosarcoma viral oncogene homolog hsa:3586 IL10; interleukin 10 hsa:3552 IL1A; interleukin 1, alpha hsa:3553 IL1B; interleukin 1, beta hsa:51561 IL23A; interleukin 23, alpha subunit p19 hsa:3569 IL6; interleukin 6 (interferon, beta 2) hsa:3576 IL8; interleukin 8 hsa:3654 IRAK1; interleukin-1 receptor-associated kinase 1 (EC:2.7.11.1) hsa:3678 ITGA5; integrin, alpha 5 (fibronectin receptor, alpha polypeptide) hsa:3684 ITGAM; integrin, alpha M (complement component 3 receptor 3 subunit) hsa:3688 ITGB1; integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) hsa:3689 ITGB2; integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) hsa:3725 JUN; jun proto-oncogene hsa:23643 LY96; lymphocyte antigen 96 hsa:5594 MAPK1; mitogen-activated protein kinase 1 (EC:2.7.11.24) hsa:1432 MAPK14; mitogen-activated protein kinase 14 (EC:2.7.11.24) hsa:5595 MAPK3; mitogen-activated protein kinase 3 (EC:2.7.11.24) hsa:5599 MAPK8; mitogen-activated protein kinase 8 (EC:2.7.11.24) hsa:4790 NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 hsa:10392 NOD1; nucleotide-binding oligomerization domain containing 1 hsa:4843 NOS2; nitric oxide synthase 2, inducible (EC:1.14.13.39) hsa:5970 RELA; v-rel avian reticuloendotheliosis viral oncogene homolog A hsa:387 RHOA; ras homolog family member A hsa:710 SERPING1; serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 hsa:148022 TICAM1; toll-like receptor adaptor molecule 1 hsa:7099 TLR4; toll-like receptor 4 hsa:7124 TNF; tumor necrosis factor hsa:7189 TRAF6; TNF receptor-associated factor 6, E3 ubiquitin protein ligase

hsa04932 Non-alcoholic fatty liver disease (NAFLD) - Homo sapiens (human) (37)

hsa:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) hsa:581 BAX; BCL2-associated X protein hsa:637 BID; BH3 interacting domain death agonist hsa:836 CASP3; caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) hsa:840 CASP7; caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) hsa:841 CASP8; caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) hsa:998 CDC42; cell division cycle 42 hsa:4512 COX1; cytochrome c oxidase subunit I hsa:54205 CYCS; cytochrome c, somatic hsa:1649 DDIT3; DNA-damage-inducible transcript 3 hsa:355 FAS; Fas cell surface death receptor hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26) hsa:3551 IKBKB; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta (EC:2.7.11.10) hsa:3552 IL1A; interleukin 1, alpha hsa:3553 IL1B; interleukin 1, beta hsa:3569 IL6; interleukin 6 (interferon, beta 2) hsa:3576 IL8; interleukin 8 hsa:3667 IRS1; insulin receptor substrate 1 hsa:3725 JUN; jun proto-oncogene hsa:3952 LEP; leptin hsa:5599 MAPK8; mitogen-activated protein kinase 8 (EC:2.7.11.24) hsa:4697 NDUFA4; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4, 9kDa (EC:1.6.5.3 1.6.99.3) hsa:4725 NDUFS5; NADH dehydrogenase (ubiquinone) Fe-S protein 5, 15kDa (NADH-coenzyme Q reductase) hsa:4729 NDUFV2; NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa (EC:1.6.5.3 1.6.99.3) hsa:4790 NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha) hsa:5879 RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) hsa:5970 RELA; v-rel avian reticuloendotheliosis viral oncogene homolog A hsa:6389 SDHA; succinate dehydrogenase complex, subunit A, flavoprotein (Fp) (EC:1.3.5.1) hsa:6390 SDHB; succinate dehydrogenase complex, subunit B, iron sulfur (Ip) (EC:1.3.5.1) hsa:6391 SDHC; succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa hsa:6392 SDHD; succinate dehydrogenase complex, subunit D, integral membrane protein hsa:6720 SREBF1; sterol regulatory element binding transcription factor 1 hsa:7040 TGFB1; transforming growth factor, beta 1 hsa:7124 TNF; tumor necrosis factor hsa:7132 TNFRSF1A; tumor necrosis factor receptor superfamily, member 1A hsa:7494 XBP1; X-box binding protein 1

hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human) (37)

cpd:C00025 L-Glutamate cpd:C00388 Histamine cpd:C00584 Prostaglandin E2 cpd:C01598 Melatonin cpd:C02165 Leukotriene B4 cpd:C02166 Leukotriene C4 cpd:C03758 Dopamine cpd:C04598 2-Acetyl-1-alkyl-sn-glycero-3-phosphocholine hsa:185 AGTR1; angiotensin II receptor, type 1 hsa:186 AGTR2; angiotensin II receptor, type 2 hsa:886 CCKAR; cholecystokinin A receptor hsa:887 CCKBR; cholecystokinin B receptor hsa:1129 CHRM2; cholinergic receptor, muscarinic 2 hsa:2147 F2; coagulation factor II (thrombin) (EC:3.4.21.5) hsa:2149 F2R; coagulation factor II (thrombin) receptor hsa:2150 F2RL1; coagulation factor II (thrombin) receptor-like 1 hsa:2358 FPR2; formyl peptide receptor 2 hsa:2359 FPR3; formyl peptide receptor 3 hsa:9248 GPR50; G protein-coupled receptor 50 hsa:2902 GRIN1; glutamate receptor, ionotropic, N-methyl D-aspartate 1 hsa:2903 GRIN2A; glutamate receptor, ionotropic, N-methyl D-aspartate 2A hsa:2904 GRIN2B; glutamate receptor, ionotropic, N-methyl D-aspartate 2B hsa:2905 GRIN2C; glutamate receptor, ionotropic, N-methyl D-aspartate 2C hsa:2906 GRIN2D; glutamate receptor, ionotropic, N-methyl D-aspartate 2D hsa:116443 GRIN3A; glutamate receptor, ionotropic, N-methyl-D-aspartate 3A hsa:116444 GRIN3B; glutamate receptor, ionotropic, N-methyl-D-aspartate 3B hsa:3274 HRH2; histamine receptor H2 hsa:11255 HRH3; histamine receptor H3 hsa:3952 LEP; leptin hsa:2908 NR3C1; nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) hsa:5029 P2RY2; purinergic receptor P2Y, G-protein coupled, 2 hsa:5340 PLG; plasminogen (EC:3.4.21.7) hsa:5644 PRSS1; protease, serine, 1 (trypsin 1) (EC:3.4.21.4) hsa:6752 SSTR2; somatostatin receptor 2 hsa:6753 SSTR3; somatostatin receptor 3 hsa:7067 THRA; thyroid hormone receptor, alpha hsa:7434 VIPR2; vasoactive intestinal peptide receptor 2

hsa05220 Chronic myeloid leukemia - Homo sapiens (human) (37)

hsa:25 ABL1; c-abl oncogene 1, non-receptor tyrosine kinase (EC:2.7.10.2) hsa:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) hsa:572 BAD; BCL2-associated agonist of cell death hsa:598 BCL2L1; BCL2-like 1 hsa:673 BRAF; v-raf murine sarcoma viral oncogene homolog B (EC:2.7.11.1) hsa:595 CCND1; cyclin D1 hsa:1019 CDK4; cyclin-dependent kinase 4 (EC:2.7.11.22) hsa:1026 CDKN1A; cyclin-dependent kinase inhibitor 1A (p21, Cip1) hsa:1027 CDKN1B; cyclin-dependent kinase inhibitor 1B (p27, Kip1) hsa:1029 CDKN2A; cyclin-dependent kinase inhibitor 2A hsa:1147 CHUK; conserved helix-loop-helix ubiquitous kinase (EC:2.7.11.10) hsa:1398 CRK; v-crk avian sarcoma virus CT10 oncogene homolog hsa:1399 CRKL; v-crk avian sarcoma virus CT10 oncogene homolog-like hsa:1869 E2F1; E2F transcription factor 1 hsa:1870 E2F2; E2F transcription factor 2 hsa:2885 GRB2; growth factor receptor-bound protein 2 hsa:3551 IKBKB; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta (EC:2.7.11.10) hsa:8517 IKBKG; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma hsa:3845 KRAS; Kirsten rat sarcoma viral oncogene homolog hsa:5604 MAP2K1; mitogen-activated protein kinase kinase 1 (EC:2.7.12.2) hsa:5594 MAPK1; mitogen-activated protein kinase 1 (EC:2.7.11.24) hsa:5595 MAPK3; mitogen-activated protein kinase 3 (EC:2.7.11.24) hsa:4193 MDM2; MDM2 oncogene, E3 ubiquitin protein ligase hsa:4609 MYC; v-myc avian myelocytomatosis viral oncogene homolog hsa:4790 NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 hsa:4792 NFKBIA; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha hsa:4893 NRAS; neuroblastoma RAS viral (v-ras) oncogene homolog hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha) hsa:5781 PTPN11; protein tyrosine phosphatase, non-receptor type 11 (EC:3.1.3.48) hsa:5894 RAF1; v-raf-1 murine leukemia viral oncogene homolog 1 (EC:2.7.11.1) hsa:5970 RELA; v-rel avian reticuloendotheliosis viral oncogene homolog A hsa:6654 SOS1; son of sevenless homolog 1 (Drosophila) hsa:6776 STAT5A; signal transducer and activator of transcription 5A hsa:6777 STAT5B; signal transducer and activator of transcription 5B hsa:7040 TGFB1; transforming growth factor, beta 1 hsa:7042 TGFB2; transforming growth factor, beta 2 hsa:7157 TP53; tumor protein p53

hsa05212 Pancreatic cancer - Homo sapiens (human) (37)

hsa:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) hsa:9459 ARHGEF6; Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6 hsa:572 BAD; BCL2-associated agonist of cell death hsa:598 BCL2L1; BCL2-like 1 hsa:673 BRAF; v-raf murine sarcoma viral oncogene homolog B (EC:2.7.11.1) hsa:842 CASP9; caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) hsa:595 CCND1; cyclin D1 hsa:998 CDC42; cell division cycle 42 hsa:1019 CDK4; cyclin-dependent kinase 4 (EC:2.7.11.22) hsa:1029 CDKN2A; cyclin-dependent kinase inhibitor 2A hsa:1147 CHUK; conserved helix-loop-helix ubiquitous kinase (EC:2.7.11.10) hsa:1869 E2F1; E2F transcription factor 1 hsa:1870 E2F2; E2F transcription factor 2 hsa:1950 EGF; epidermal growth factor hsa:1956 EGFR; epidermal growth factor receptor (EC:2.7.10.1) hsa:2064 ERBB2; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (EC:2.7.10.1) hsa:3551 IKBKB; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta (EC:2.7.11.10) hsa:8517 IKBKG; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma hsa:3845 KRAS; Kirsten rat sarcoma viral oncogene homolog hsa:5604 MAP2K1; mitogen-activated protein kinase kinase 1 (EC:2.7.12.2) hsa:5594 MAPK1; mitogen-activated protein kinase 1 (EC:2.7.11.24) hsa:5595 MAPK3; mitogen-activated protein kinase 3 (EC:2.7.11.24) hsa:5599 MAPK8; mitogen-activated protein kinase 8 (EC:2.7.11.24) hsa:4790 NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha) hsa:5337 PLD1; phospholipase D1, phosphatidylcholine-specific (EC:3.1.4.4) hsa:5879 RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) hsa:5880 RAC2; ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) hsa:5894 RAF1; v-raf-1 murine leukemia viral oncogene homolog 1 (EC:2.7.11.1) hsa:5970 RELA; v-rel avian reticuloendotheliosis viral oncogene homolog A hsa:6772 STAT1; signal transducer and activator of transcription 1, 91kDa hsa:6774 STAT3; signal transducer and activator of transcription 3 (acute-phase response factor) hsa:7039 TGFA; transforming growth factor, alpha hsa:7040 TGFB1; transforming growth factor, beta 1 hsa:7042 TGFB2; transforming growth factor, beta 2 hsa:7157 TP53; tumor protein p53 hsa:7422 VEGFA; vascular endothelial growth factor A

hsa04210 Apoptosis - Homo sapiens (human) (36)

hsa:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) hsa:472 ATM; ataxia telangiectasia mutated (EC:2.7.11.1) hsa:572 BAD; BCL2-associated agonist of cell death hsa:581 BAX; BCL2-associated X protein hsa:596 BCL2; B-cell CLL/lymphoma 2 hsa:598 BCL2L1; BCL2-like 1 hsa:637 BID; BH3 interacting domain death agonist hsa:329 BIRC2; baculoviral IAP repeat containing 2 hsa:330 BIRC3; baculoviral IAP repeat containing 3 hsa:823 CAPN1; calpain 1, (mu/I) large subunit (EC:3.4.22.52) hsa:836 CASP3; caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) hsa:840 CASP7; caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) hsa:841 CASP8; caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) hsa:842 CASP9; caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) hsa:1147 CHUK; conserved helix-loop-helix ubiquitous kinase (EC:2.7.11.10) hsa:1439 CSF2RB; colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) hsa:54205 CYCS; cytochrome c, somatic hsa:355 FAS; Fas cell surface death receptor hsa:3551 IKBKB; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta (EC:2.7.11.10) hsa:8517 IKBKG; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma hsa:3552 IL1A; interleukin 1, alpha hsa:3553 IL1B; interleukin 1, beta hsa:3554 IL1R1; interleukin 1 receptor, type I hsa:3562 IL3; interleukin 3 (colony-stimulating factor, multiple) hsa:3563 IL3RA; interleukin 3 receptor, alpha (low affinity) hsa:3654 IRAK1; interleukin-1 receptor-associated kinase 1 (EC:2.7.11.1) hsa:9020 MAP3K14; mitogen-activated protein kinase kinase kinase 14 (EC:2.7.11.25) hsa:4790 NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 hsa:4792 NFKBIA; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha) hsa:5530 PPP3CA; protein phosphatase 3, catalytic subunit, alpha isozyme (EC:3.1.3.16) hsa:5970 RELA; v-rel avian reticuloendotheliosis viral oncogene homolog A hsa:7124 TNF; tumor necrosis factor hsa:7132 TNFRSF1A; tumor necrosis factor receptor superfamily, member 1A hsa:7157 TP53; tumor protein p53 hsa:8717 TRADD; TNFRSF1A-associated via death domain

hsa04670 Leukocyte transendothelial migration - Homo sapiens (human) (35)

cpd:C00027 Hydrogen peroxide hsa:998 CDC42; cell division cycle 42 hsa:53842 CLDN22; claudin 22 hsa:1364 CLDN4; claudin 4 hsa:7122 CLDN5; claudin 5 hsa:1499 CTNNB1; catenin (cadherin-associated protein), beta 1, 88kDa hsa:1500 CTNND1; catenin (cadherin-associated protein), delta 1 hsa:7852 CXCR4; chemokine (C-X-C motif) receptor 4 hsa:1536 CYBB; cytochrome b-245, beta polypeptide hsa:7430 EZR; ezrin hsa:50848 F11R; F11 receptor hsa:3383 ICAM1; intercellular adhesion molecule 1 hsa:3683 ITGAL; integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) hsa:3684 ITGAM; integrin, alpha M (complement component 3 receptor 3 subunit) hsa:3688 ITGB1; integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) hsa:3689 ITGB2; integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) hsa:1432 MAPK14; mitogen-activated protein kinase 14 (EC:2.7.11.24) hsa:4318 MMP9; matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) hsa:4478 MSN; moesin hsa:27035 NOX1; NADPH oxidase 1 hsa:100506658 OCLN; occludin (EC:2.1.1.67) hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha) hsa:5335 PLCG1; phospholipase C, gamma 1 (EC:3.1.4.11) hsa:5578 PRKCA; protein kinase C, alpha (EC:2.7.11.13) hsa:5747 PTK2; protein tyrosine kinase 2 (EC:2.7.10.2) hsa:5781 PTPN11; protein tyrosine phosphatase, non-receptor type 11 (EC:3.1.3.48) hsa:5829 PXN; paxillin hsa:5879 RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) hsa:5880 RAC2; ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) hsa:5906 RAP1A; RAP1A, member of RAS oncogene family hsa:387 RHOA; ras homolog family member A hsa:7408 VASP; vasodilator-stimulated phosphoprotein hsa:7409 VAV1; vav 1 guanine nucleotide exchange factor hsa:7412 VCAM1; vascular cell adhesion molecule 1 hsa:7414 VCL; vinculin

hsa05132 Salmonella infection - Homo sapiens (human) (34)

cpd:C00062 L-Arginine cpd:C00338 Lipopolysaccharide cpd:C00533 Nitric oxide hsa:10093 ARPC4; actin related protein 2/3 complex, subunit 4, 20kDa hsa:6348 CCL3; chemokine (C-C motif) ligand 3 hsa:6351 CCL4; chemokine (C-C motif) ligand 4 hsa:929 CD14; CD14 molecule hsa:998 CDC42; cell division cycle 42 hsa:1437 CSF2; colony stimulating factor 2 (granulocyte-macrophage) hsa:2919 CXCL1; chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) hsa:2920 CXCL2; chemokine (C-X-C motif) ligand 2 hsa:2921 CXCL3; chemokine (C-X-C motif) ligand 3 hsa:2353 FOS; FBJ murine osteosarcoma viral oncogene homolog hsa:3458 IFNG; interferon, gamma hsa:3459 IFNGR1; interferon gamma receptor 1 hsa:3552 IL1A; interleukin 1, alpha hsa:3553 IL1B; interleukin 1, beta hsa:3569 IL6; interleukin 6 (interferon, beta 2) hsa:3576 IL8; interleukin 8 hsa:3725 JUN; jun proto-oncogene hsa:3929 LBP; lipopolysaccharide binding protein hsa:5594 MAPK1; mitogen-activated protein kinase 1 (EC:2.7.11.24) hsa:1432 MAPK14; mitogen-activated protein kinase 14 (EC:2.7.11.24) hsa:5595 MAPK3; mitogen-activated protein kinase 3 (EC:2.7.11.24) hsa:5599 MAPK8; mitogen-activated protein kinase 8 (EC:2.7.11.24) hsa:4790 NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 hsa:4843 NOS2; nitric oxide synthase 2, inducible (EC:1.14.13.39) hsa:5879 RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) hsa:5970 RELA; v-rel avian reticuloendotheliosis viral oncogene homolog A hsa:7082 TJP1; tight junction protein 1 hsa:7099 TLR4; toll-like receptor 4 hsa:7100 TLR5; toll-like receptor 5 hsa:8936 WASF1; WAS protein family, member 1 hsa:8976 WASL; Wiskott-Aldrich syndrome-like

hsa05222 Small cell lung cancer - Homo sapiens (human) (34)

hsa:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) hsa:596 BCL2; B-cell CLL/lymphoma 2 hsa:598 BCL2L1; BCL2-like 1 hsa:329 BIRC2; baculoviral IAP repeat containing 2 hsa:330 BIRC3; baculoviral IAP repeat containing 3 hsa:842 CASP9; caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) hsa:595 CCND1; cyclin D1 hsa:1019 CDK4; cyclin-dependent kinase 4 (EC:2.7.11.22) hsa:1027 CDKN1B; cyclin-dependent kinase inhibitor 1B (p27, Kip1) hsa:1147 CHUK; conserved helix-loop-helix ubiquitous kinase (EC:2.7.11.10) hsa:54205 CYCS; cytochrome c, somatic hsa:1869 E2F1; E2F transcription factor 1 hsa:1870 E2F2; E2F transcription factor 2 hsa:2335 FN1; fibronectin 1 hsa:3551 IKBKB; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta (EC:2.7.11.10) hsa:8517 IKBKG; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma hsa:3673 ITGA2; integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) hsa:3688 ITGB1; integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) hsa:284217 LAMA1; laminin, alpha 1 hsa:3912 LAMB1; laminin, beta 1 hsa:3915 LAMC1; laminin, gamma 1 (formerly LAMB2) hsa:4609 MYC; v-myc avian myelocytomatosis viral oncogene homolog hsa:4790 NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 hsa:4792 NFKBIA; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha hsa:4843 NOS2; nitric oxide synthase 2, inducible (EC:1.14.13.39) hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha) hsa:5728 PTEN; phosphatase and tensin homolog (EC:3.1.3.67 3.1.3.16 3.1.3.48) hsa:5743 PTGS2; prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) hsa:5747 PTK2; protein tyrosine kinase 2 (EC:2.7.10.2) hsa:5970 RELA; v-rel avian reticuloendotheliosis viral oncogene homolog A hsa:6502 SKP2; S-phase kinase-associated protein 2, E3 ubiquitin protein ligase hsa:7157 TP53; tumor protein p53 hsa:9618 TRAF4; TNF receptor-associated factor 4 hsa:7189 TRAF6; TNF receptor-associated factor 6, E3 ubiquitin protein ligase

hsa05321 Inflammatory bowel disease (IBD) - Homo sapiens (human) (34)

hsa:3108 HLA-DMA; major histocompatibility complex, class II, DM alpha hsa:3117 HLA-DQA1; major histocompatibility complex, class II, DQ alpha 1 hsa:3119 HLA-DQB1; major histocompatibility complex, class II, DQ beta 1 hsa:3122 HLA-DRA; major histocompatibility complex, class II, DR alpha hsa:3125 HLA-DRB3; major histocompatibility complex, class II, DR beta 3 hsa:3127 HLA-DRB5; major histocompatibility complex, class II, DR beta 5 hsa:3458 IFNG; interferon, gamma hsa:3459 IFNGR1; interferon gamma receptor 1 hsa:3586 IL10; interleukin 10 hsa:3596 IL13; interleukin 13 hsa:3605 IL17A; interleukin 17A hsa:8807 IL18RAP; interleukin 18 receptor accessory protein hsa:3552 IL1A; interleukin 1, alpha hsa:3553 IL1B; interleukin 1, beta hsa:3558 IL2; interleukin 2 hsa:51561 IL23A; interleukin 23, alpha subunit p19 hsa:3561 IL2RG; interleukin 2 receptor, gamma hsa:3565 IL4; interleukin 4 hsa:3566 IL4R; interleukin 4 receptor hsa:3569 IL6; interleukin 6 (interferon, beta 2) hsa:3725 JUN; jun proto-oncogene hsa:4094 MAF; v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog hsa:4790 NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 hsa:64127 NOD2; nucleotide-binding oligomerization domain containing 2 hsa:5970 RELA; v-rel avian reticuloendotheliosis viral oncogene homolog A hsa:6772 STAT1; signal transducer and activator of transcription 1, 91kDa hsa:6774 STAT3; signal transducer and activator of transcription 3 (acute-phase response factor) hsa:6778 STAT6; signal transducer and activator of transcription 6, interleukin-4 induced hsa:7040 TGFB1; transforming growth factor, beta 1 hsa:7042 TGFB2; transforming growth factor, beta 2 hsa:7097 TLR2; toll-like receptor 2 hsa:7099 TLR4; toll-like receptor 4 hsa:7100 TLR5; toll-like receptor 5 hsa:7124 TNF; tumor necrosis factor

hsa04664 Fc epsilon RI signaling pathway - Homo sapiens (human) (33)

cpd:C00374 Heparin cpd:C00388 Histamine cpd:C02166 Leukotriene C4 hsa:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) hsa:695 BTK; Bruton agammaglobulinemia tyrosine kinase (EC:2.7.10.2) hsa:1437 CSF2; colony stimulating factor 2 (granulocyte-macrophage) hsa:2534 FYN; FYN oncogene related to SRC, FGR, YES (EC:2.7.10.2) hsa:2885 GRB2; growth factor receptor-bound protein 2 hsa:3596 IL13; interleukin 13 hsa:3562 IL3; interleukin 3 (colony-stimulating factor, multiple) hsa:3565 IL4; interleukin 4 hsa:3845 KRAS; Kirsten rat sarcoma viral oncogene homolog hsa:3937 LCP2; lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) hsa:4067 LYN; v-yes-1 Yamaguchi sarcoma viral related oncogene homolog (EC:2.7.10.2) hsa:5604 MAP2K1; mitogen-activated protein kinase kinase 1 (EC:2.7.12.2) hsa:5606 MAP2K3; mitogen-activated protein kinase kinase 3 (EC:2.7.12.2) hsa:6416 MAP2K4; mitogen-activated protein kinase kinase 4 (EC:2.7.12.2) hsa:5594 MAPK1; mitogen-activated protein kinase 1 (EC:2.7.11.24) hsa:1432 MAPK14; mitogen-activated protein kinase 14 (EC:2.7.11.24) hsa:5595 MAPK3; mitogen-activated protein kinase 3 (EC:2.7.11.24) hsa:5599 MAPK8; mitogen-activated protein kinase 8 (EC:2.7.11.24) hsa:4893 NRAS; neuroblastoma RAS viral (v-ras) oncogene homolog hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha) hsa:5335 PLCG1; phospholipase C, gamma 1 (EC:3.1.4.11) hsa:5578 PRKCA; protein kinase C, alpha (EC:2.7.11.13) hsa:5580 PRKCD; protein kinase C, delta (EC:2.7.10.2 2.7.11.13) hsa:5879 RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) hsa:5880 RAC2; ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) hsa:5894 RAF1; v-raf-1 murine leukemia viral oncogene homolog 1 (EC:2.7.11.1) hsa:6654 SOS1; son of sevenless homolog 1 (Drosophila) hsa:6850 SYK; spleen tyrosine kinase (EC:2.7.10.2) hsa:7124 TNF; tumor necrosis factor hsa:7409 VAV1; vav 1 guanine nucleotide exchange factor

hsa04390 Hippo signaling pathway - Homo sapiens (human) (33)

hsa:324 APC; adenomatous polyposis coli hsa:374 AREG; amphiregulin hsa:329 BIRC2; baculoviral IAP repeat containing 2 hsa:332 BIRC5; baculoviral IAP repeat containing 5 hsa:650 BMP2; bone morphogenetic protein 2 hsa:652 BMP4; bone morphogenetic protein 4 hsa:655 BMP7; bone morphogenetic protein 7 hsa:595 CCND1; cyclin D1 hsa:999 CDH1; cadherin 1, type 1, E-cadherin (epithelial) hsa:1490 CTGF; connective tissue growth factor hsa:1499 CTNNB1; catenin (cadherin-associated protein), beta 1, 88kDa hsa:1742 DLG4; discs, large homolog 4 (Drosophila) hsa:1856 DVL2; dishevelled segment polarity protein 2 hsa:1857 DVL3; dishevelled segment polarity protein 3 hsa:8200 GDF5; growth differentiation factor 5 hsa:2736 GLI2; GLI family zinc finger 2 hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26) hsa:3398 ID2; inhibitor of DNA binding 2, dominant negative helix-loop-helix protein hsa:3689 ITGB2; integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) hsa:26524 LATS2; large tumor suppressor kinase 2 (EC:2.7.11.1) hsa:51176 LEF1; lymphoid enhancer-binding factor 1 hsa:4609 MYC; v-myc avian myelocytomatosis viral oncogene homolog hsa:5590 PRKCZ; protein kinase C, zeta (EC:2.7.11.13) hsa:5054 SERPINE1; serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 hsa:4092 SMAD7; SMAD family member 7 hsa:6591 SNAI2; snail family zinc finger 2 hsa:7040 TGFB1; transforming growth factor, beta 1 hsa:7042 TGFB2; transforming growth factor, beta 2 hsa:7159 TP53BP2; tumor protein p53 binding protein, 2 hsa:7161 TP73; tumor protein p73 hsa:7472 WNT2; wingless-type MMTV integration site family member 2 hsa:7529 YWHAB; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide hsa:10971 YWHAQ; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide

hsa04917 Prolactin signaling pathway - Homo sapiens (human) (32)

cpd:C00082 L-Tyrosine cpd:C00280 Androstenedione cpd:C00355 3,4-Dihydroxy-L-phenylalanine cpd:C00468 Estrone cpd:C00951 Estradiol-17beta cpd:C03758 Dopamine hsa:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) hsa:595 CCND1; cyclin D1 hsa:2001 ELF5; E74-like factor 5 (ets domain transcription factor) hsa:2353 FOS; FBJ murine osteosarcoma viral oncogene homolog hsa:2885 GRB2; growth factor receptor-bound protein 2 hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26) hsa:3717 JAK2; Janus kinase 2 (EC:2.7.10.2) hsa:3845 KRAS; Kirsten rat sarcoma viral oncogene homolog hsa:5604 MAP2K1; mitogen-activated protein kinase kinase 1 (EC:2.7.12.2) hsa:5594 MAPK1; mitogen-activated protein kinase 1 (EC:2.7.11.24) hsa:1432 MAPK14; mitogen-activated protein kinase 14 (EC:2.7.11.24) hsa:5595 MAPK3; mitogen-activated protein kinase 3 (EC:2.7.11.24) hsa:5599 MAPK8; mitogen-activated protein kinase 8 (EC:2.7.11.24) hsa:4790 NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 hsa:4893 NRAS; neuroblastoma RAS viral (v-ras) oncogene homolog hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha) hsa:5894 RAF1; v-raf-1 murine leukemia viral oncogene homolog 1 (EC:2.7.11.1) hsa:5970 RELA; v-rel avian reticuloendotheliosis viral oncogene homolog A hsa:8835 SOCS2; suppressor of cytokine signaling 2 hsa:6654 SOS1; son of sevenless homolog 1 (Drosophila) hsa:6714 SRC; v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (EC:2.7.10.2) hsa:6772 STAT1; signal transducer and activator of transcription 1, 91kDa hsa:6774 STAT3; signal transducer and activator of transcription 3 (acute-phase response factor) hsa:6776 STAT5A; signal transducer and activator of transcription 5A hsa:6777 STAT5B; signal transducer and activator of transcription 5B hsa:8600 TNFSF11; tumor necrosis factor (ligand) superfamily, member 11

hsa04640 Hematopoietic cell lineage - Homo sapiens (human) (32)

hsa:929 CD14; CD14 molecule hsa:945 CD33; CD33 molecule hsa:948 CD36; CD36 molecule (thrombospondin receptor) hsa:915 CD3D; CD3d molecule, delta (CD3-TCR complex) hsa:960 CD44; CD44 molecule (Indian blood group) hsa:1604 CD55; CD55 molecule, decay accelerating factor for complement (Cromer blood group) hsa:1378 CR1; complement component (3b/4b) receptor 1 (Knops blood group) hsa:1437 CSF2; colony stimulating factor 2 (granulocyte-macrophage) hsa:1441 CSF3R; colony stimulating factor 3 receptor (granulocyte) hsa:2811 GP1BA; glycoprotein Ib (platelet), alpha polypeptide hsa:3122 HLA-DRA; major histocompatibility complex, class II, DR alpha hsa:3125 HLA-DRB3; major histocompatibility complex, class II, DR beta 3 hsa:3127 HLA-DRB5; major histocompatibility complex, class II, DR beta 5 hsa:3589 IL11; interleukin 11 hsa:3552 IL1A; interleukin 1, alpha hsa:3553 IL1B; interleukin 1, beta hsa:3554 IL1R1; interleukin 1 receptor, type I hsa:7850 IL1R2; interleukin 1 receptor, type II hsa:3559 IL2RA; interleukin 2 receptor, alpha hsa:3562 IL3; interleukin 3 (colony-stimulating factor, multiple) hsa:3563 IL3RA; interleukin 3 receptor, alpha (low affinity) hsa:3565 IL4; interleukin 4 hsa:3566 IL4R; interleukin 4 receptor hsa:3569 IL6; interleukin 6 (interferon, beta 2) hsa:3574 IL7; interleukin 7 hsa:3575 IL7R; interleukin 7 receptor hsa:3581 IL9R; interleukin 9 receptor hsa:3673 ITGA2; integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) hsa:3678 ITGA5; integrin, alpha 5 (fibronectin receptor, alpha polypeptide) hsa:3684 ITGAM; integrin, alpha M (complement component 3 receptor 3 subunit) hsa:7124 TNF; tumor necrosis factor hsa:7173 TPO; thyroid peroxidase (EC:1.11.1.8)

hsa05034 Alcoholism - Homo sapiens (human) (32)

cpd:C00025 L-Glutamate cpd:C00027 Hydrogen peroxide cpd:C00082 L-Tyrosine cpd:C00355 3,4-Dihydroxy-L-phenylalanine cpd:C03758 Dopamine hsa:1386 ATF2; activating transcription factor 2 hsa:673 BRAF; v-raf murine sarcoma viral oncogene homolog B (EC:2.7.11.1) hsa:1385 CREB1; cAMP responsive element binding protein 1 hsa:9586 CREB5; cAMP responsive element binding protein 5 hsa:1644 DDC; dopa decarboxylase (aromatic L-amino acid decarboxylase) (EC:4.1.1.28) hsa:2778 GNAS; GNAS complex locus hsa:2783 GNB2; guanine nucleotide binding protein (G protein), beta polypeptide 2 hsa:2885 GRB2; growth factor receptor-bound protein 2 hsa:2902 GRIN1; glutamate receptor, ionotropic, N-methyl D-aspartate 1 hsa:2903 GRIN2A; glutamate receptor, ionotropic, N-methyl D-aspartate 2A hsa:2904 GRIN2B; glutamate receptor, ionotropic, N-methyl D-aspartate 2B hsa:2905 GRIN2C; glutamate receptor, ionotropic, N-methyl D-aspartate 2C hsa:2906 GRIN2D; glutamate receptor, ionotropic, N-methyl D-aspartate 2D hsa:116443 GRIN3A; glutamate receptor, ionotropic, N-methyl-D-aspartate 3A hsa:116444 GRIN3B; glutamate receptor, ionotropic, N-methyl-D-aspartate 3B hsa:3014 H2AFX; H2A histone family, member X hsa:8334 HIST1H2AC; histone cluster 1, H2ac hsa:8329 HIST1H2AI; histone cluster 1, H2ai hsa:8356 HIST1H3J; histone cluster 1, H3j hsa:3845 KRAS; Kirsten rat sarcoma viral oncogene homolog hsa:4128 MAOA; monoamine oxidase A (EC:1.4.3.4) hsa:5604 MAP2K1; mitogen-activated protein kinase kinase 1 (EC:2.7.12.2) hsa:5594 MAPK1; mitogen-activated protein kinase 1 (EC:2.7.11.24) hsa:5595 MAPK3; mitogen-activated protein kinase 3 (EC:2.7.11.24) hsa:4893 NRAS; neuroblastoma RAS viral (v-ras) oncogene homolog hsa:5894 RAF1; v-raf-1 murine leukemia viral oncogene homolog 1 (EC:2.7.11.1) hsa:6654 SOS1; son of sevenless homolog 1 (Drosophila)

hsa05210 Colorectal cancer - Homo sapiens (human) (31)

hsa:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) hsa:324 APC; adenomatous polyposis coli hsa:572 BAD; BCL2-associated agonist of cell death hsa:581 BAX; BCL2-associated X protein hsa:596 BCL2; B-cell CLL/lymphoma 2 hsa:332 BIRC5; baculoviral IAP repeat containing 5 hsa:673 BRAF; v-raf murine sarcoma viral oncogene homolog B (EC:2.7.11.1) hsa:836 CASP3; caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) hsa:842 CASP9; caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) hsa:595 CCND1; cyclin D1 hsa:1499 CTNNB1; catenin (cadherin-associated protein), beta 1, 88kDa hsa:54205 CYCS; cytochrome c, somatic hsa:2353 FOS; FBJ murine osteosarcoma viral oncogene homolog hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26) hsa:3725 JUN; jun proto-oncogene hsa:3845 KRAS; Kirsten rat sarcoma viral oncogene homolog hsa:51176 LEF1; lymphoid enhancer-binding factor 1 hsa:5604 MAP2K1; mitogen-activated protein kinase kinase 1 (EC:2.7.12.2) hsa:5594 MAPK1; mitogen-activated protein kinase 1 (EC:2.7.11.24) hsa:5595 MAPK3; mitogen-activated protein kinase 3 (EC:2.7.11.24) hsa:5599 MAPK8; mitogen-activated protein kinase 8 (EC:2.7.11.24) hsa:4292 MLH1; mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) hsa:4609 MYC; v-myc avian myelocytomatosis viral oncogene homolog hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha) hsa:5879 RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) hsa:5880 RAC2; ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) hsa:5894 RAF1; v-raf-1 murine leukemia viral oncogene homolog 1 (EC:2.7.11.1) hsa:387 RHOA; ras homolog family member A hsa:7040 TGFB1; transforming growth factor, beta 1 hsa:7042 TGFB2; transforming growth factor, beta 2 hsa:7157 TP53; tumor protein p53

hsa04915 Estrogen signaling pathway - Homo sapiens (human) (31)

cpd:C00533 Nitric oxide cpd:C00951 Estradiol-17beta hsa:115 ADCY9; adenylate cyclase 9 (EC:4.6.1.1) hsa:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) hsa:1386 ATF2; activating transcription factor 2 hsa:1385 CREB1; cAMP responsive element binding protein 1 hsa:9586 CREB5; cAMP responsive element binding protein 5 hsa:1956 EGFR; epidermal growth factor receptor (EC:2.7.10.1) hsa:2353 FOS; FBJ murine osteosarcoma viral oncogene homolog hsa:2778 GNAS; GNAS complex locus hsa:2885 GRB2; growth factor receptor-bound protein 2 hsa:1839 HBEGF; heparin-binding EGF-like growth factor hsa:3320 HSP90AA1; heat shock protein 90kDa alpha (cytosolic), class A member 1 hsa:3326 HSP90AB1; heat shock protein 90kDa alpha (cytosolic), class B member 1 hsa:7184 HSP90B1; heat shock protein 90kDa beta (Grp94), member 1 hsa:3312 HSPA8; heat shock 70kDa protein 8 hsa:3709 ITPR2; inositol 1,4,5-trisphosphate receptor, type 2 hsa:3725 JUN; jun proto-oncogene hsa:3845 KRAS; Kirsten rat sarcoma viral oncogene homolog hsa:5604 MAP2K1; mitogen-activated protein kinase kinase 1 (EC:2.7.12.2) hsa:5594 MAPK1; mitogen-activated protein kinase 1 (EC:2.7.11.24) hsa:5595 MAPK3; mitogen-activated protein kinase 3 (EC:2.7.11.24) hsa:4318 MMP9; matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) hsa:4893 NRAS; neuroblastoma RAS viral (v-ras) oncogene homolog hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha) hsa:5330 PLCB2; phospholipase C, beta 2 (EC:3.1.4.11) hsa:5332 PLCB4; phospholipase C, beta 4 (EC:3.1.4.11) hsa:5580 PRKCD; protein kinase C, delta (EC:2.7.10.2 2.7.11.13) hsa:5894 RAF1; v-raf-1 murine leukemia viral oncogene homolog 1 (EC:2.7.11.1) hsa:6654 SOS1; son of sevenless homolog 1 (Drosophila) hsa:6714 SRC; v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (EC:2.7.10.2)

hsa05211 Renal cell carcinoma - Homo sapiens (human) (31)

cpd:C00007 Oxygen hsa:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) hsa:673 BRAF; v-raf murine sarcoma viral oncogene homolog B (EC:2.7.11.1) hsa:998 CDC42; cell division cycle 42 hsa:1398 CRK; v-crk avian sarcoma virus CT10 oncogene homolog hsa:1399 CRKL; v-crk avian sarcoma virus CT10 oncogene homolog-like hsa:2271 FH; fumarate hydratase (EC:4.2.1.2) hsa:2549 GAB1; GRB2-associated binding protein 1 hsa:2885 GRB2; growth factor receptor-bound protein 2 hsa:3091 HIF1A; hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) hsa:3725 JUN; jun proto-oncogene hsa:3845 KRAS; Kirsten rat sarcoma viral oncogene homolog hsa:5604 MAP2K1; mitogen-activated protein kinase kinase 1 (EC:2.7.12.2) hsa:5594 MAPK1; mitogen-activated protein kinase 1 (EC:2.7.11.24) hsa:5595 MAPK3; mitogen-activated protein kinase 3 (EC:2.7.11.24) hsa:4233 MET; met proto-oncogene (EC:2.7.10.1) hsa:4893 NRAS; neuroblastoma RAS viral (v-ras) oncogene homolog hsa:5058 PAK1; p21 protein (Cdc42/Rac)-activated kinase 1 (EC:2.7.11.1) hsa:5062 PAK2; p21 protein (Cdc42/Rac)-activated kinase 2 (EC:2.7.11.1) hsa:5155 PDGFB; platelet-derived growth factor beta polypeptide hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha) hsa:5781 PTPN11; protein tyrosine phosphatase, non-receptor type 11 (EC:3.1.3.48) hsa:5879 RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) hsa:5894 RAF1; v-raf-1 murine leukemia viral oncogene homolog 1 (EC:2.7.11.1) hsa:5906 RAP1A; RAP1A, member of RAS oncogene family hsa:6654 SOS1; son of sevenless homolog 1 (Drosophila) hsa:6923 TCEB2; transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B) hsa:7039 TGFA; transforming growth factor, alpha hsa:7040 TGFB1; transforming growth factor, beta 1 hsa:7042 TGFB2; transforming growth factor, beta 2 hsa:7422 VEGFA; vascular endothelial growth factor A

hsa04144 Endocytosis - Homo sapiens (human) (30)

hsa:408 ARRB1; arrestin, beta 1 hsa:857 CAV1; caveolin 1, caveolae protein, 22kDa hsa:998 CDC42; cell division cycle 42 hsa:3579 CXCR2; chemokine (C-X-C motif) receptor 2 hsa:7852 CXCR4; chemokine (C-X-C motif) receptor 4 hsa:1950 EGF; epidermal growth factor hsa:1956 EGFR; epidermal growth factor receptor (EC:2.7.10.1) hsa:2149 F2R; coagulation factor II (thrombin) receptor hsa:2263 FGFR2; fibroblast growth factor receptor 2 (EC:2.7.10.1) hsa:2261 FGFR3; fibroblast growth factor receptor 3 (EC:2.7.10.1) hsa:28964 GIT1; G protein-coupled receptor kinase interacting ArfGAP 1 hsa:3106 HLA-B; major histocompatibility complex, class I, B hsa:3134 HLA-F; major histocompatibility complex, class I, F hsa:3312 HSPA8; heat shock 70kDa protein 8 hsa:3559 IL2RA; interleukin 2 receptor, alpha hsa:3560 IL2RB; interleukin 2 receptor, beta hsa:3561 IL2RG; interleukin 2 receptor, gamma hsa:3949 LDLR; low density lipoprotein receptor hsa:4193 MDM2; MDM2 oncogene, E3 ubiquitin protein ligase hsa:4233 MET; met proto-oncogene (EC:2.7.10.1) hsa:8395 PIP5K1B; phosphatidylinositol-4-phosphate 5-kinase, type I, beta (EC:2.7.1.68) hsa:5337 PLD1; phospholipase D1, phosphatidylcholine-specific (EC:3.1.4.4) hsa:5590 PRKCZ; protein kinase C, zeta (EC:2.7.11.13) hsa:387 RHOA; ras homolog family member A hsa:4092 SMAD7; SMAD family member 7 hsa:6714 SRC; v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (EC:2.7.10.2) hsa:7040 TGFB1; transforming growth factor, beta 1 hsa:7042 TGFB2; transforming growth factor, beta 2 hsa:7189 TRAF6; TNF receptor-associated factor 6, E3 ubiquitin protein ligase hsa:9372 ZFYVE9; zinc finger, FYVE domain containing 9

hsa04662 B cell receptor signaling pathway - Homo sapiens (human) (30)

hsa:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) hsa:29760 BLNK; B-cell linker hsa:695 BTK; Bruton agammaglobulinemia tyrosine kinase (EC:2.7.10.2) hsa:1147 CHUK; conserved helix-loop-helix ubiquitous kinase (EC:2.7.11.10) hsa:2353 FOS; FBJ murine osteosarcoma viral oncogene homolog hsa:2885 GRB2; growth factor receptor-bound protein 2 hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26) hsa:8519 IFITM1; interferon induced transmembrane protein 1 hsa:3551 IKBKB; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta (EC:2.7.11.10) hsa:8517 IKBKG; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma hsa:3636 INPPL1; inositol polyphosphate phosphatase-like 1 (EC:3.1.3.86) hsa:3725 JUN; jun proto-oncogene hsa:3845 KRAS; Kirsten rat sarcoma viral oncogene homolog hsa:4067 LYN; v-yes-1 Yamaguchi sarcoma viral related oncogene homolog (EC:2.7.10.2) hsa:5604 MAP2K1; mitogen-activated protein kinase kinase 1 (EC:2.7.12.2) hsa:5594 MAPK1; mitogen-activated protein kinase 1 (EC:2.7.11.24) hsa:5595 MAPK3; mitogen-activated protein kinase 3 (EC:2.7.11.24) hsa:4790 NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 hsa:4792 NFKBIA; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha hsa:4893 NRAS; neuroblastoma RAS viral (v-ras) oncogene homolog hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha) hsa:5530 PPP3CA; protein phosphatase 3, catalytic subunit, alpha isozyme (EC:3.1.3.16) hsa:5777 PTPN6; protein tyrosine phosphatase, non-receptor type 6 (EC:3.1.3.48) hsa:5879 RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) hsa:5880 RAC2; ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) hsa:5894 RAF1; v-raf-1 murine leukemia viral oncogene homolog 1 (EC:2.7.11.1) hsa:5970 RELA; v-rel avian reticuloendotheliosis viral oncogene homolog A hsa:6654 SOS1; son of sevenless homolog 1 (Drosophila) hsa:6850 SYK; spleen tyrosine kinase (EC:2.7.10.2) hsa:7409 VAV1; vav 1 guanine nucleotide exchange factor

hsa05014 Amyotrophic lateral sclerosis (ALS) - Homo sapiens (human) (29)

cpd:C00025 L-Glutamate cpd:C00027 Hydrogen peroxide cpd:C00062 L-Arginine cpd:C00533 Nitric oxide cpd:C16845 Peroxynitrite hsa:572 BAD; BCL2-associated agonist of cell death hsa:581 BAX; BCL2-associated X protein hsa:596 BCL2; B-cell CLL/lymphoma 2 hsa:598 BCL2L1; BCL2-like 1 hsa:637 BID; BH3 interacting domain death agonist hsa:836 CASP3; caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) hsa:842 CASP9; caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) hsa:847 CAT; catalase (EC:1.11.1.6) hsa:54205 CYCS; cytochrome c, somatic hsa:2902 GRIN1; glutamate receptor, ionotropic, N-methyl D-aspartate 1 hsa:2903 GRIN2A; glutamate receptor, ionotropic, N-methyl D-aspartate 2A hsa:2904 GRIN2B; glutamate receptor, ionotropic, N-methyl D-aspartate 2B hsa:2905 GRIN2C; glutamate receptor, ionotropic, N-methyl D-aspartate 2C hsa:2906 GRIN2D; glutamate receptor, ionotropic, N-methyl D-aspartate 2D hsa:5606 MAP2K3; mitogen-activated protein kinase kinase 3 (EC:2.7.12.2) hsa:1432 MAPK14; mitogen-activated protein kinase 14 (EC:2.7.11.24) hsa:4842 NOS1; nitric oxide synthase 1 (neuronal) (EC:1.14.13.39) hsa:5530 PPP3CA; protein phosphatase 3, catalytic subunit, alpha isozyme (EC:3.1.3.16) hsa:5879 RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) hsa:7124 TNF; tumor necrosis factor hsa:7132 TNFRSF1A; tumor necrosis factor receptor superfamily, member 1A hsa:7133 TNFRSF1B; tumor necrosis factor receptor superfamily, member 1B hsa:10452 TOMM40; translocase of outer mitochondrial membrane 40 homolog (yeast) hsa:7157 TP53; tumor protein p53

hsa05218 Melanoma - Homo sapiens (human) (29)

hsa:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) hsa:572 BAD; BCL2-associated agonist of cell death hsa:673 BRAF; v-raf murine sarcoma viral oncogene homolog B (EC:2.7.11.1) hsa:595 CCND1; cyclin D1 hsa:999 CDH1; cadherin 1, type 1, E-cadherin (epithelial) hsa:1019 CDK4; cyclin-dependent kinase 4 (EC:2.7.11.22) hsa:1026 CDKN1A; cyclin-dependent kinase inhibitor 1A (p21, Cip1) hsa:1029 CDKN2A; cyclin-dependent kinase inhibitor 2A hsa:1869 E2F1; E2F transcription factor 1 hsa:1870 E2F2; E2F transcription factor 2 hsa:1950 EGF; epidermal growth factor hsa:1956 EGFR; epidermal growth factor receptor (EC:2.7.10.1) hsa:2258 FGF13; fibroblast growth factor 13 hsa:2247 FGF2; fibroblast growth factor 2 (basic) hsa:26281 FGF20; fibroblast growth factor 20 hsa:3479 IGF1; insulin-like growth factor 1 (somatomedin C) hsa:3845 KRAS; Kirsten rat sarcoma viral oncogene homolog hsa:5604 MAP2K1; mitogen-activated protein kinase kinase 1 (EC:2.7.12.2) hsa:5594 MAPK1; mitogen-activated protein kinase 1 (EC:2.7.11.24) hsa:5595 MAPK3; mitogen-activated protein kinase 3 (EC:2.7.11.24) hsa:4193 MDM2; MDM2 oncogene, E3 ubiquitin protein ligase hsa:4233 MET; met proto-oncogene (EC:2.7.10.1) hsa:4893 NRAS; neuroblastoma RAS viral (v-ras) oncogene homolog hsa:5154 PDGFA; platelet-derived growth factor alpha polypeptide hsa:5155 PDGFB; platelet-derived growth factor beta polypeptide hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha) hsa:5728 PTEN; phosphatase and tensin homolog (EC:3.1.3.67 3.1.3.16 3.1.3.48) hsa:5894 RAF1; v-raf-1 murine leukemia viral oncogene homolog 1 (EC:2.7.11.1) hsa:7157 TP53; tumor protein p53

hsa04621 NOD-like receptor signaling pathway - Homo sapiens (human) (29)

hsa:329 BIRC2; baculoviral IAP repeat containing 2 hsa:330 BIRC3; baculoviral IAP repeat containing 3 hsa:841 CASP8; caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) hsa:6347 CCL2; chemokine (C-C motif) ligand 2 hsa:6352 CCL5; chemokine (C-C motif) ligand 5 hsa:1147 CHUK; conserved helix-loop-helix ubiquitous kinase (EC:2.7.11.10) hsa:2919 CXCL1; chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) hsa:2920 CXCL2; chemokine (C-X-C motif) ligand 2 hsa:3320 HSP90AA1; heat shock protein 90kDa alpha (cytosolic), class A member 1 hsa:3326 HSP90AB1; heat shock protein 90kDa alpha (cytosolic), class B member 1 hsa:7184 HSP90B1; heat shock protein 90kDa beta (Grp94), member 1 hsa:3551 IKBKB; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta (EC:2.7.11.10) hsa:8517 IKBKG; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma hsa:3553 IL1B; interleukin 1, beta hsa:3569 IL6; interleukin 6 (interferon, beta 2) hsa:3576 IL8; interleukin 8 hsa:6885 MAP3K7; mitogen-activated protein kinase kinase kinase 7 (EC:2.7.11.25) hsa:5594 MAPK1; mitogen-activated protein kinase 1 (EC:2.7.11.24) hsa:1432 MAPK14; mitogen-activated protein kinase 14 (EC:2.7.11.24) hsa:5595 MAPK3; mitogen-activated protein kinase 3 (EC:2.7.11.24) hsa:5599 MAPK8; mitogen-activated protein kinase 8 (EC:2.7.11.24) hsa:4210 MEFV; Mediterranean fever hsa:4790 NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 hsa:4792 NFKBIA; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha hsa:10392 NOD1; nucleotide-binding oligomerization domain containing 1 hsa:64127 NOD2; nucleotide-binding oligomerization domain containing 2 hsa:5970 RELA; v-rel avian reticuloendotheliosis viral oncogene homolog A hsa:7124 TNF; tumor necrosis factor hsa:7189 TRAF6; TNF receptor-associated factor 6, E3 ubiquitin protein ligase

hsa05134 Legionellosis - Homo sapiens (human) (29)

cpd:C00338 Lipopolysaccharide hsa:718 C3; complement component 3 (EC:3.4.21.43) hsa:836 CASP3; caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) hsa:840 CASP7; caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) hsa:841 CASP8; caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) hsa:842 CASP9; caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) hsa:929 CD14; CD14 molecule hsa:1378 CR1; complement component (3b/4b) receptor 1 (Knops blood group) hsa:2919 CXCL1; chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) hsa:2920 CXCL2; chemokine (C-X-C motif) ligand 2 hsa:2921 CXCL3; chemokine (C-X-C motif) ligand 3 hsa:54205 CYCS; cytochrome c, somatic hsa:1915 EEF1A1; eukaryotic translation elongation factor 1 alpha 1 hsa:3297 HSF1; heat shock transcription factor 1 hsa:3312 HSPA8; heat shock 70kDa protein 8 hsa:3329 HSPD1; heat shock 60kDa protein 1 (chaperonin) hsa:3553 IL1B; interleukin 1, beta hsa:3569 IL6; interleukin 6 (interferon, beta 2) hsa:3576 IL8; interleukin 8 hsa:3684 ITGAM; integrin, alpha M (complement component 3 receptor 3 subunit) hsa:3689 ITGB2; integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) hsa:4790 NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 hsa:4792 NFKBIA; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha hsa:5970 RELA; v-rel avian reticuloendotheliosis viral oncogene homolog A hsa:7097 TLR2; toll-like receptor 2 hsa:7099 TLR4; toll-like receptor 4 hsa:7100 TLR5; toll-like receptor 5 hsa:7124 TNF; tumor necrosis factor hsa:7415 VCP; valosin containing protein (EC:3.6.4.6)

hsa04514 Cell adhesion molecules (CAMs) - Homo sapiens (human) (29)

hsa:23705 CADM1; cell adhesion molecule 1 hsa:999 CDH1; cadherin 1, type 1, E-cadherin (epithelial) hsa:53842 CLDN22; claudin 22 hsa:1364 CLDN4; claudin 4 hsa:7122 CLDN5; claudin 5 hsa:6900 CNTN2; contactin 2 (axonal) hsa:1493 CTLA4; cytotoxic T-lymphocyte-associated protein 4 hsa:50848 F11R; F11 receptor hsa:3106 HLA-B; major histocompatibility complex, class I, B hsa:3108 HLA-DMA; major histocompatibility complex, class II, DM alpha hsa:3117 HLA-DQA1; major histocompatibility complex, class II, DQ alpha 1 hsa:3119 HLA-DQB1; major histocompatibility complex, class II, DQ beta 1 hsa:3122 HLA-DRA; major histocompatibility complex, class II, DR alpha hsa:3125 HLA-DRB3; major histocompatibility complex, class II, DR beta 3 hsa:3127 HLA-DRB5; major histocompatibility complex, class II, DR beta 5 hsa:3134 HLA-F; major histocompatibility complex, class I, F hsa:3383 ICAM1; intercellular adhesion molecule 1 hsa:3683 ITGAL; integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) hsa:3684 ITGAM; integrin, alpha M (complement component 3 receptor 3 subunit) hsa:3688 ITGB1; integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) hsa:3689 ITGB2; integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) hsa:8174 MADCAM1; mucosal vascular addressin cell adhesion molecule 1 hsa:4685 NCAM2; neural cell adhesion molecule 2 hsa:4897 NRCAM; neuronal cell adhesion molecule hsa:100506658 OCLN; occludin (EC:2.1.1.67) hsa:5788 PTPRC; protein tyrosine phosphatase, receptor type, C (EC:3.1.3.48) hsa:6385 SDC4; syndecan 4 hsa:6403 SELP; selectin P (granule membrane protein 140kDa, antigen CD62) hsa:7412 VCAM1; vascular cell adhesion molecule 1

hsa05131 Shigellosis - Homo sapiens (human) (29)

hsa:25 ABL1; c-abl oncogene 1, non-receptor tyrosine kinase (EC:2.7.10.2) hsa:10093 ARPC4; actin related protein 2/3 complex, subunit 4, 20kDa hsa:9474 ATG5; autophagy related 5 hsa:960 CD44; CD44 molecule (Indian blood group) hsa:998 CDC42; cell division cycle 42 hsa:1147 CHUK; conserved helix-loop-helix ubiquitous kinase (EC:2.7.11.10) hsa:1398 CRK; v-crk avian sarcoma virus CT10 oncogene homolog hsa:1399 CRKL; v-crk avian sarcoma virus CT10 oncogene homolog-like hsa:2017 CTTN; cortactin hsa:1793 DOCK1; dedicator of cytokinesis 1 hsa:3551 IKBKB; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta (EC:2.7.11.10) hsa:8517 IKBKG; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma hsa:3576 IL8; interleukin 8 hsa:3678 ITGA5; integrin, alpha 5 (fibronectin receptor, alpha polypeptide) hsa:3688 ITGB1; integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) hsa:5594 MAPK1; mitogen-activated protein kinase 1 (EC:2.7.11.24) hsa:1432 MAPK14; mitogen-activated protein kinase 14 (EC:2.7.11.24) hsa:5595 MAPK3; mitogen-activated protein kinase 3 (EC:2.7.11.24) hsa:5599 MAPK8; mitogen-activated protein kinase 8 (EC:2.7.11.24) hsa:4790 NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 hsa:4792 NFKBIA; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha hsa:10392 NOD1; nucleotide-binding oligomerization domain containing 1 hsa:64127 NOD2; nucleotide-binding oligomerization domain containing 2 hsa:5879 RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) hsa:5970 RELA; v-rel avian reticuloendotheliosis viral oncogene homolog A hsa:6714 SRC; v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (EC:2.7.10.2) hsa:7414 VCL; vinculin hsa:8936 WASF1; WAS protein family, member 1 hsa:8976 WASL; Wiskott-Aldrich syndrome-like

hsa04666 Fc gamma R-mediated phagocytosis - Homo sapiens (human) (28)

hsa:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) hsa:10093 ARPC4; actin related protein 2/3 complex, subunit 4, 20kDa hsa:998 CDC42; cell division cycle 42 hsa:1398 CRK; v-crk avian sarcoma virus CT10 oncogene homolog hsa:1399 CRKL; v-crk avian sarcoma virus CT10 oncogene homolog-like hsa:3055 HCK; hemopoietic cell kinase (EC:2.7.10.2) hsa:3636 INPPL1; inositol polyphosphate phosphatase-like 1 (EC:3.1.3.86) hsa:4067 LYN; v-yes-1 Yamaguchi sarcoma viral related oncogene homolog (EC:2.7.10.2) hsa:5604 MAP2K1; mitogen-activated protein kinase kinase 1 (EC:2.7.12.2) hsa:5594 MAPK1; mitogen-activated protein kinase 1 (EC:2.7.11.24) hsa:5595 MAPK3; mitogen-activated protein kinase 3 (EC:2.7.11.24) hsa:5058 PAK1; p21 protein (Cdc42/Rac)-activated kinase 1 (EC:2.7.11.1) hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha) hsa:8395 PIP5K1B; phosphatidylinositol-4-phosphate 5-kinase, type I, beta (EC:2.7.1.68) hsa:5335 PLCG1; phospholipase C, gamma 1 (EC:3.1.4.11) hsa:5337 PLD1; phospholipase D1, phosphatidylcholine-specific (EC:3.1.4.4) hsa:8613 PPAP2B; phosphatidic acid phosphatase type 2B (EC:3.1.3.4) hsa:5578 PRKCA; protein kinase C, alpha (EC:2.7.11.13) hsa:5580 PRKCD; protein kinase C, delta (EC:2.7.10.2 2.7.11.13) hsa:5788 PTPRC; protein tyrosine phosphatase, receptor type, C (EC:3.1.3.48) hsa:5879 RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) hsa:5880 RAC2; ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) hsa:5894 RAF1; v-raf-1 murine leukemia viral oncogene homolog 1 (EC:2.7.11.1) hsa:6850 SYK; spleen tyrosine kinase (EC:2.7.10.2) hsa:7408 VASP; vasodilator-stimulated phosphoprotein hsa:7409 VAV1; vav 1 guanine nucleotide exchange factor hsa:8936 WASF1; WAS protein family, member 1 hsa:8976 WASL; Wiskott-Aldrich syndrome-like

hsa05214 Glioma - Homo sapiens (human) (28)

hsa:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) hsa:673 BRAF; v-raf murine sarcoma viral oncogene homolog B (EC:2.7.11.1) hsa:595 CCND1; cyclin D1 hsa:1019 CDK4; cyclin-dependent kinase 4 (EC:2.7.11.22) hsa:1026 CDKN1A; cyclin-dependent kinase inhibitor 1A (p21, Cip1) hsa:1029 CDKN2A; cyclin-dependent kinase inhibitor 2A hsa:1869 E2F1; E2F transcription factor 1 hsa:1870 E2F2; E2F transcription factor 2 hsa:1950 EGF; epidermal growth factor hsa:1956 EGFR; epidermal growth factor receptor (EC:2.7.10.1) hsa:2885 GRB2; growth factor receptor-bound protein 2 hsa:3479 IGF1; insulin-like growth factor 1 (somatomedin C) hsa:3845 KRAS; Kirsten rat sarcoma viral oncogene homolog hsa:5604 MAP2K1; mitogen-activated protein kinase kinase 1 (EC:2.7.12.2) hsa:5594 MAPK1; mitogen-activated protein kinase 1 (EC:2.7.11.24) hsa:5595 MAPK3; mitogen-activated protein kinase 3 (EC:2.7.11.24) hsa:4193 MDM2; MDM2 oncogene, E3 ubiquitin protein ligase hsa:4893 NRAS; neuroblastoma RAS viral (v-ras) oncogene homolog hsa:5154 PDGFA; platelet-derived growth factor alpha polypeptide hsa:5155 PDGFB; platelet-derived growth factor beta polypeptide hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha) hsa:5335 PLCG1; phospholipase C, gamma 1 (EC:3.1.4.11) hsa:5578 PRKCA; protein kinase C, alpha (EC:2.7.11.13) hsa:5728 PTEN; phosphatase and tensin homolog (EC:3.1.3.67 3.1.3.16 3.1.3.48) hsa:5894 RAF1; v-raf-1 murine leukemia viral oncogene homolog 1 (EC:2.7.11.1) hsa:6654 SOS1; son of sevenless homolog 1 (Drosophila) hsa:7039 TGFA; transforming growth factor, alpha hsa:7157 TP53; tumor protein p53

hsa04910 Insulin signaling pathway - Homo sapiens (human) (28)

hsa:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) hsa:572 BAD; BCL2-associated agonist of cell death hsa:673 BRAF; v-raf murine sarcoma viral oncogene homolog B (EC:2.7.11.1) hsa:1398 CRK; v-crk avian sarcoma virus CT10 oncogene homolog hsa:1399 CRKL; v-crk avian sarcoma virus CT10 oncogene homolog-like hsa:2002 ELK1; ELK1, member of ETS oncogene family hsa:10211 FLOT1; flotillin 1 hsa:2308 FOXO1; forkhead box O1 hsa:2885 GRB2; growth factor receptor-bound protein 2 hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26) hsa:3551 IKBKB; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta (EC:2.7.11.10) hsa:3636 INPPL1; inositol polyphosphate phosphatase-like 1 (EC:3.1.3.86) hsa:3667 IRS1; insulin receptor substrate 1 hsa:3845 KRAS; Kirsten rat sarcoma viral oncogene homolog hsa:5604 MAP2K1; mitogen-activated protein kinase kinase 1 (EC:2.7.12.2) hsa:5594 MAPK1; mitogen-activated protein kinase 1 (EC:2.7.11.24) hsa:5595 MAPK3; mitogen-activated protein kinase 3 (EC:2.7.11.24) hsa:5599 MAPK8; mitogen-activated protein kinase 8 (EC:2.7.11.24) hsa:4893 NRAS; neuroblastoma RAS viral (v-ras) oncogene homolog hsa:5106 PCK2; phosphoenolpyruvate carboxykinase 2 (mitochondrial) (EC:4.1.1.32) hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha) hsa:89801 PPP1R3F; protein phosphatase 1, regulatory subunit 3F hsa:5590 PRKCZ; protein kinase C, zeta (EC:2.7.11.13) hsa:5894 RAF1; v-raf-1 murine leukemia viral oncogene homolog 1 (EC:2.7.11.1) hsa:8835 SOCS2; suppressor of cytokine signaling 2 hsa:10580 SORBS1; sorbin and SH3 domain containing 1 hsa:6654 SOS1; son of sevenless homolog 1 (Drosophila) hsa:6720 SREBF1; sterol regulatory element binding transcription factor 1

hsa04912 GnRH signaling pathway - Homo sapiens (human) (28)

hsa:115 ADCY9; adenylate cyclase 9 (EC:4.6.1.1) hsa:998 CDC42; cell division cycle 42 hsa:1956 EGFR; epidermal growth factor receptor (EC:2.7.10.1) hsa:2002 ELK1; ELK1, member of ETS oncogene family hsa:2778 GNAS; GNAS complex locus hsa:2885 GRB2; growth factor receptor-bound protein 2 hsa:1839 HBEGF; heparin-binding EGF-like growth factor hsa:3709 ITPR2; inositol 1,4,5-trisphosphate receptor, type 2 hsa:3725 JUN; jun proto-oncogene hsa:3845 KRAS; Kirsten rat sarcoma viral oncogene homolog hsa:5604 MAP2K1; mitogen-activated protein kinase kinase 1 (EC:2.7.12.2) hsa:5606 MAP2K3; mitogen-activated protein kinase kinase 3 (EC:2.7.12.2) hsa:6416 MAP2K4; mitogen-activated protein kinase kinase 4 (EC:2.7.12.2) hsa:4214 MAP3K1; mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase (EC:2.7.11.25) hsa:10746 MAP3K2; mitogen-activated protein kinase kinase kinase 2 (EC:2.7.11.25) hsa:5594 MAPK1; mitogen-activated protein kinase 1 (EC:2.7.11.24) hsa:1432 MAPK14; mitogen-activated protein kinase 14 (EC:2.7.11.24) hsa:5595 MAPK3; mitogen-activated protein kinase 3 (EC:2.7.11.24) hsa:5599 MAPK8; mitogen-activated protein kinase 8 (EC:2.7.11.24) hsa:4893 NRAS; neuroblastoma RAS viral (v-ras) oncogene homolog hsa:5330 PLCB2; phospholipase C, beta 2 (EC:3.1.4.11) hsa:5332 PLCB4; phospholipase C, beta 4 (EC:3.1.4.11) hsa:5337 PLD1; phospholipase D1, phosphatidylcholine-specific (EC:3.1.4.4) hsa:5578 PRKCA; protein kinase C, alpha (EC:2.7.11.13) hsa:5580 PRKCD; protein kinase C, delta (EC:2.7.10.2 2.7.11.13) hsa:5894 RAF1; v-raf-1 murine leukemia viral oncogene homolog 1 (EC:2.7.11.1) hsa:6654 SOS1; son of sevenless homolog 1 (Drosophila) hsa:6714 SRC; v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (EC:2.7.10.2)

hsa04520 Adherens junction - Homo sapiens (human) (28)

hsa:998 CDC42; cell division cycle 42 hsa:999 CDH1; cadherin 1, type 1, E-cadherin (epithelial) hsa:1457 CSNK2A1; casein kinase 2, alpha 1 polypeptide (EC:2.7.11.1) hsa:1499 CTNNB1; catenin (cadherin-associated protein), beta 1, 88kDa hsa:1500 CTNND1; catenin (cadherin-associated protein), delta 1 hsa:1956 EGFR; epidermal growth factor receptor (EC:2.7.10.1) hsa:2064 ERBB2; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (EC:2.7.10.1) hsa:2534 FYN; FYN oncogene related to SRC, FGR, YES (EC:2.7.10.2) hsa:51176 LEF1; lymphoid enhancer-binding factor 1 hsa:4008 LMO7; LIM domain 7 hsa:6885 MAP3K7; mitogen-activated protein kinase kinase kinase 7 (EC:2.7.11.25) hsa:5594 MAPK1; mitogen-activated protein kinase 1 (EC:2.7.11.24) hsa:5595 MAPK3; mitogen-activated protein kinase 3 (EC:2.7.11.24) hsa:4233 MET; met proto-oncogene (EC:2.7.10.1) hsa:5777 PTPN6; protein tyrosine phosphatase, non-receptor type 6 (EC:3.1.3.48) hsa:5787 PTPRB; protein tyrosine phosphatase, receptor type, B (EC:3.1.3.48) hsa:5879 RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) hsa:5880 RAC2; ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) hsa:387 RHOA; ras homolog family member A hsa:6615 SNAI1; snail family zinc finger 1 hsa:6591 SNAI2; snail family zinc finger 2 hsa:10580 SORBS1; sorbin and SH3 domain containing 1 hsa:6714 SRC; v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (EC:2.7.10.2) hsa:7082 TJP1; tight junction protein 1 hsa:7414 VCL; vinculin hsa:8936 WASF1; WAS protein family, member 1 hsa:8976 WASL; Wiskott-Aldrich syndrome-like hsa:7525 YES1; v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1 (EC:2.7.10.2)

hsa05213 Endometrial cancer - Homo sapiens (human) (28)

hsa:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) hsa:324 APC; adenomatous polyposis coli hsa:572 BAD; BCL2-associated agonist of cell death hsa:673 BRAF; v-raf murine sarcoma viral oncogene homolog B (EC:2.7.11.1) hsa:842 CASP9; caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) hsa:595 CCND1; cyclin D1 hsa:999 CDH1; cadherin 1, type 1, E-cadherin (epithelial) hsa:1499 CTNNB1; catenin (cadherin-associated protein), beta 1, 88kDa hsa:1950 EGF; epidermal growth factor hsa:1956 EGFR; epidermal growth factor receptor (EC:2.7.10.1) hsa:2002 ELK1; ELK1, member of ETS oncogene family hsa:2064 ERBB2; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (EC:2.7.10.1) hsa:2885 GRB2; growth factor receptor-bound protein 2 hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26) hsa:3611 ILK; integrin-linked kinase (EC:2.7.11.1) hsa:3845 KRAS; Kirsten rat sarcoma viral oncogene homolog hsa:51176 LEF1; lymphoid enhancer-binding factor 1 hsa:5604 MAP2K1; mitogen-activated protein kinase kinase 1 (EC:2.7.12.2) hsa:5594 MAPK1; mitogen-activated protein kinase 1 (EC:2.7.11.24) hsa:5595 MAPK3; mitogen-activated protein kinase 3 (EC:2.7.11.24) hsa:4292 MLH1; mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) hsa:4609 MYC; v-myc avian myelocytomatosis viral oncogene homolog hsa:4893 NRAS; neuroblastoma RAS viral (v-ras) oncogene homolog hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha) hsa:5728 PTEN; phosphatase and tensin homolog (EC:3.1.3.67 3.1.3.16 3.1.3.48) hsa:5894 RAF1; v-raf-1 murine leukemia viral oncogene homolog 1 (EC:2.7.11.1) hsa:6654 SOS1; son of sevenless homolog 1 (Drosophila) hsa:7157 TP53; tumor protein p53

hsa04310 Wnt signaling pathway - Homo sapiens (human) (27)

hsa:324 APC; adenomatous polyposis coli hsa:595 CCND1; cyclin D1 hsa:1457 CSNK2A1; casein kinase 2, alpha 1 polypeptide (EC:2.7.11.1) hsa:1499 CTNNB1; catenin (cadherin-associated protein), beta 1, 88kDa hsa:1856 DVL2; dishevelled segment polarity protein 2 hsa:1857 DVL3; dishevelled segment polarity protein 3 hsa:8061 FOSL1; FOS-like antigen 1 hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26) hsa:3725 JUN; jun proto-oncogene hsa:51176 LEF1; lymphoid enhancer-binding factor 1 hsa:4040 LRP6; low density lipoprotein receptor-related protein 6 hsa:6885 MAP3K7; mitogen-activated protein kinase kinase kinase 7 (EC:2.7.11.25) hsa:5599 MAPK8; mitogen-activated protein kinase 8 (EC:2.7.11.24) hsa:4316 MMP7; matrix metallopeptidase 7 (matrilysin, uterine) (EC:3.4.24.23) hsa:4609 MYC; v-myc avian myelocytomatosis viral oncogene homolog hsa:4776 NFATC4; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 hsa:5330 PLCB2; phospholipase C, beta 2 (EC:3.1.4.11) hsa:5332 PLCB4; phospholipase C, beta 4 (EC:3.1.4.11) hsa:5467 PPARD; peroxisome proliferator-activated receptor delta hsa:5530 PPP3CA; protein phosphatase 3, catalytic subunit, alpha isozyme (EC:3.1.3.16) hsa:5578 PRKCA; protein kinase C, alpha (EC:2.7.11.13) hsa:5663 PSEN1; presenilin 1 (EC:3.4.23.-) hsa:5879 RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) hsa:5880 RAC2; ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) hsa:387 RHOA; ras homolog family member A hsa:7157 TP53; tumor protein p53 hsa:7472 WNT2; wingless-type MMTV integration site family member 2

hsa05219 Bladder cancer - Homo sapiens (human) (27)

hsa:673 BRAF; v-raf murine sarcoma viral oncogene homolog B (EC:2.7.11.1) hsa:595 CCND1; cyclin D1 hsa:999 CDH1; cadherin 1, type 1, E-cadherin (epithelial) hsa:1019 CDK4; cyclin-dependent kinase 4 (EC:2.7.11.22) hsa:1026 CDKN1A; cyclin-dependent kinase inhibitor 1A (p21, Cip1) hsa:1029 CDKN2A; cyclin-dependent kinase inhibitor 2A hsa:1869 E2F1; E2F transcription factor 1 hsa:1870 E2F2; E2F transcription factor 2 hsa:1950 EGF; epidermal growth factor hsa:1956 EGFR; epidermal growth factor receptor (EC:2.7.10.1) hsa:2064 ERBB2; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (EC:2.7.10.1) hsa:2261 FGFR3; fibroblast growth factor receptor 3 (EC:2.7.10.1) hsa:3576 IL8; interleukin 8 hsa:3845 KRAS; Kirsten rat sarcoma viral oncogene homolog hsa:5604 MAP2K1; mitogen-activated protein kinase kinase 1 (EC:2.7.12.2) hsa:5594 MAPK1; mitogen-activated protein kinase 1 (EC:2.7.11.24) hsa:5595 MAPK3; mitogen-activated protein kinase 3 (EC:2.7.11.24) hsa:4193 MDM2; MDM2 oncogene, E3 ubiquitin protein ligase hsa:4312 MMP1; matrix metallopeptidase 1 (interstitial collagenase) (EC:3.4.24.7) hsa:4318 MMP9; matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) hsa:4609 MYC; v-myc avian myelocytomatosis viral oncogene homolog hsa:4893 NRAS; neuroblastoma RAS viral (v-ras) oncogene homolog hsa:5894 RAF1; v-raf-1 murine leukemia viral oncogene homolog 1 (EC:2.7.11.1) hsa:9252 RPS6KA5; ribosomal protein S6 kinase, 90kDa, polypeptide 5 (EC:2.7.11.1) hsa:7057 THBS1; thrombospondin 1 hsa:7157 TP53; tumor protein p53 hsa:7422 VEGFA; vascular endothelial growth factor A

hsa04530 Tight junction - Homo sapiens (human) (27)

hsa:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) hsa:998 CDC42; cell division cycle 42 hsa:1019 CDK4; cyclin-dependent kinase 4 (EC:2.7.11.22) hsa:53842 CLDN22; claudin 22 hsa:1364 CLDN4; claudin 4 hsa:7122 CLDN5; claudin 5 hsa:1457 CSNK2A1; casein kinase 2, alpha 1 polypeptide (EC:2.7.11.1) hsa:1499 CTNNB1; catenin (cadherin-associated protein), beta 1, 88kDa hsa:2017 CTTN; cortactin hsa:50848 F11R; F11 receptor hsa:3845 KRAS; Kirsten rat sarcoma viral oncogene homolog hsa:4629 MYH11; myosin, heavy chain 11, smooth muscle hsa:57644 MYH7B; myosin, heavy chain 7B, cardiac muscle, beta hsa:4893 NRAS; neuroblastoma RAS viral (v-ras) oncogene homolog hsa:100506658 OCLN; occludin (EC:2.1.1.67) hsa:5578 PRKCA; protein kinase C, alpha (EC:2.7.11.13) hsa:5580 PRKCD; protein kinase C, delta (EC:2.7.10.2 2.7.11.13) hsa:5583 PRKCH; protein kinase C, eta (EC:2.7.11.13) hsa:5588 PRKCQ; protein kinase C, theta (EC:2.7.11.13) hsa:5590 PRKCZ; protein kinase C, zeta (EC:2.7.11.13) hsa:5728 PTEN; phosphatase and tensin homolog (EC:3.1.3.67 3.1.3.16 3.1.3.48) hsa:387 RHOA; ras homolog family member A hsa:6237 RRAS; related RAS viral (r-ras) oncogene homolog hsa:22800 RRAS2; related RAS viral (r-ras) oncogene homolog 2 hsa:6714 SRC; v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (EC:2.7.10.2) hsa:7082 TJP1; tight junction protein 1 hsa:7525 YES1; v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1 (EC:2.7.10.2)

hsa04726 Serotonergic synapse - Homo sapiens (human) (26)

cpd:C00078 L-Tryptophan cpd:C00584 Prostaglandin E2 cpd:C02165 Leukotriene B4 cpd:C02166 Leukotriene C4 hsa:240 ALOX5; arachidonate 5-lipoxygenase (EC:1.13.11.34) hsa:673 BRAF; v-raf murine sarcoma viral oncogene homolog B (EC:2.7.11.1) hsa:836 CASP3; caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) hsa:1557 CYP2C19; cytochrome P450, family 2, subfamily C, polypeptide 19 (EC:1.14.13.48 1.14.13.49 1.14.13.80) hsa:1565 CYP2D6; cytochrome P450, family 2, subfamily D, polypeptide 6 (EC:1.14.14.1) hsa:1573 CYP2J2; cytochrome P450, family 2, subfamily J, polypeptide 2 (EC:1.14.14.1) hsa:1644 DDC; dopa decarboxylase (aromatic L-amino acid decarboxylase) (EC:4.1.1.28) hsa:1843 DUSP1; dual specificity phosphatase 1 (EC:3.1.3.16 3.1.3.48) hsa:2778 GNAS; GNAS complex locus hsa:2783 GNB2; guanine nucleotide binding protein (G protein), beta polypeptide 2 hsa:3709 ITPR2; inositol 1,4,5-trisphosphate receptor, type 2 hsa:3845 KRAS; Kirsten rat sarcoma viral oncogene homolog hsa:4128 MAOA; monoamine oxidase A (EC:1.4.3.4) hsa:5604 MAP2K1; mitogen-activated protein kinase kinase 1 (EC:2.7.12.2) hsa:5594 MAPK1; mitogen-activated protein kinase 1 (EC:2.7.11.24) hsa:5595 MAPK3; mitogen-activated protein kinase 3 (EC:2.7.11.24) hsa:4893 NRAS; neuroblastoma RAS viral (v-ras) oncogene homolog hsa:5330 PLCB2; phospholipase C, beta 2 (EC:3.1.4.11) hsa:5332 PLCB4; phospholipase C, beta 4 (EC:3.1.4.11) hsa:5578 PRKCA; protein kinase C, alpha (EC:2.7.11.13) hsa:5743 PTGS2; prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) hsa:5894 RAF1; v-raf-1 murine leukemia viral oncogene homolog 1 (EC:2.7.11.1)

hsa04540 Gap junction - Homo sapiens (human) (26)

cpd:C00025 L-Glutamate cpd:C00533 Nitric oxide cpd:C03758 Dopamine hsa:115 ADCY9; adenylate cyclase 9 (EC:4.6.1.1) hsa:1950 EGF; epidermal growth factor hsa:1956 EGFR; epidermal growth factor receptor (EC:2.7.10.1) hsa:2778 GNAS; GNAS complex locus hsa:2885 GRB2; growth factor receptor-bound protein 2 hsa:3709 ITPR2; inositol 1,4,5-trisphosphate receptor, type 2 hsa:3845 KRAS; Kirsten rat sarcoma viral oncogene homolog hsa:5604 MAP2K1; mitogen-activated protein kinase kinase 1 (EC:2.7.12.2) hsa:10746 MAP3K2; mitogen-activated protein kinase kinase kinase 2 (EC:2.7.11.25) hsa:5594 MAPK1; mitogen-activated protein kinase 1 (EC:2.7.11.24) hsa:5595 MAPK3; mitogen-activated protein kinase 3 (EC:2.7.11.24) hsa:4893 NRAS; neuroblastoma RAS viral (v-ras) oncogene homolog hsa:5154 PDGFA; platelet-derived growth factor alpha polypeptide hsa:5155 PDGFB; platelet-derived growth factor beta polypeptide hsa:5330 PLCB2; phospholipase C, beta 2 (EC:3.1.4.11) hsa:5332 PLCB4; phospholipase C, beta 4 (EC:3.1.4.11) hsa:5578 PRKCA; protein kinase C, alpha (EC:2.7.11.13) hsa:5894 RAF1; v-raf-1 murine leukemia viral oncogene homolog 1 (EC:2.7.11.1) hsa:6654 SOS1; son of sevenless homolog 1 (Drosophila) hsa:6714 SRC; v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (EC:2.7.10.2) hsa:7082 TJP1; tight junction protein 1 hsa:10376 TUBA1B; tubulin, alpha 1b hsa:203068 TUBB; tubulin, beta class I

hsa04110 Cell cycle - Homo sapiens (human) (26)

hsa:25 ABL1; c-abl oncogene 1, non-receptor tyrosine kinase (EC:2.7.10.2) hsa:472 ATM; ataxia telangiectasia mutated (EC:2.7.11.1) hsa:9184 BUB3; BUB3 mitotic checkpoint protein hsa:595 CCND1; cyclin D1 hsa:8555 CDC14B; cell division cycle 14B (EC:3.1.3.16 3.1.3.48) hsa:1019 CDK4; cyclin-dependent kinase 4 (EC:2.7.11.22) hsa:1026 CDKN1A; cyclin-dependent kinase inhibitor 1A (p21, Cip1) hsa:1027 CDKN1B; cyclin-dependent kinase inhibitor 1B (p27, Kip1) hsa:1028 CDKN1C; cyclin-dependent kinase inhibitor 1C (p57, Kip2) hsa:1029 CDKN2A; cyclin-dependent kinase inhibitor 2A hsa:1869 E2F1; E2F transcription factor 1 hsa:1870 E2F2; E2F transcription factor 2 hsa:1647 GADD45A; growth arrest and DNA-damage-inducible, alpha hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26) hsa:4193 MDM2; MDM2 oncogene, E3 ubiquitin protein ligase hsa:4609 MYC; v-myc avian myelocytomatosis viral oncogene homolog hsa:5111 PCNA; proliferating cell nuclear antigen hsa:5933 RBL1; retinoblastoma-like 1 (p107) hsa:5934 RBL2; retinoblastoma-like 2 (p130) hsa:6502 SKP2; S-phase kinase-associated protein 2, E3 ubiquitin protein ligase hsa:7040 TGFB1; transforming growth factor, beta 1 hsa:7042 TGFB2; transforming growth factor, beta 2 hsa:7157 TP53; tumor protein p53 hsa:7529 YWHAB; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide hsa:10971 YWHAQ; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide hsa:7709 ZBTB17; zinc finger and BTB domain containing 17

hsa04360 Axon guidance - Homo sapiens (human) (26)

hsa:25 ABL1; c-abl oncogene 1, non-receptor tyrosine kinase (EC:2.7.10.2) hsa:998 CDC42; cell division cycle 42 hsa:1020 CDK5; cyclin-dependent kinase 5 (EC:2.7.11.22) hsa:7852 CXCR4; chemokine (C-X-C motif) receptor 4 hsa:1945 EFNA4; ephrin-A4 hsa:2041 EPHA1; EPH receptor A1 (EC:2.7.10.1) hsa:2043 EPHA4; EPH receptor A4 (EC:2.7.10.1) hsa:2534 FYN; FYN oncogene related to SRC, FGR, YES (EC:2.7.10.2) hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26) hsa:3688 ITGB1; integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) hsa:3845 KRAS; Kirsten rat sarcoma viral oncogene homolog hsa:5594 MAPK1; mitogen-activated protein kinase 1 (EC:2.7.11.24) hsa:5595 MAPK3; mitogen-activated protein kinase 3 (EC:2.7.11.24) hsa:4233 MET; met proto-oncogene (EC:2.7.10.1) hsa:4776 NFATC4; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 hsa:4893 NRAS; neuroblastoma RAS viral (v-ras) oncogene homolog hsa:5058 PAK1; p21 protein (Cdc42/Rac)-activated kinase 1 (EC:2.7.11.1) hsa:5062 PAK2; p21 protein (Cdc42/Rac)-activated kinase 2 (EC:2.7.11.1) hsa:5530 PPP3CA; protein phosphatase 3, catalytic subunit, alpha isozyme (EC:3.1.3.16) hsa:5747 PTK2; protein tyrosine kinase 2 (EC:2.7.10.2) hsa:5879 RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) hsa:5880 RAC2; ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) hsa:5921 RASA1; RAS p21 protein activator (GTPase activating protein) 1 hsa:387 RHOA; ras homolog family member A hsa:10371 SEMA3A; sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A hsa:10512 SEMA3C; sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C

hsa05416 Viral myocarditis - Homo sapiens (human) (25)

hsa:25 ABL1; c-abl oncogene 1, non-receptor tyrosine kinase (EC:2.7.10.2) hsa:637 BID; BH3 interacting domain death agonist hsa:836 CASP3; caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) hsa:841 CASP8; caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) hsa:842 CASP9; caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) hsa:857 CAV1; caveolin 1, caveolae protein, 22kDa hsa:595 CCND1; cyclin D1 hsa:1604 CD55; CD55 molecule, decay accelerating factor for complement (Cromer blood group) hsa:54205 CYCS; cytochrome c, somatic hsa:2534 FYN; FYN oncogene related to SRC, FGR, YES (EC:2.7.10.2) hsa:3106 HLA-B; major histocompatibility complex, class I, B hsa:3108 HLA-DMA; major histocompatibility complex, class II, DM alpha hsa:3117 HLA-DQA1; major histocompatibility complex, class II, DQ alpha 1 hsa:3119 HLA-DQB1; major histocompatibility complex, class II, DQ beta 1 hsa:3122 HLA-DRA; major histocompatibility complex, class II, DR alpha hsa:3125 HLA-DRB3; major histocompatibility complex, class II, DR beta 3 hsa:3127 HLA-DRB5; major histocompatibility complex, class II, DR beta 5 hsa:3134 HLA-F; major histocompatibility complex, class I, F hsa:3383 ICAM1; intercellular adhesion molecule 1 hsa:3683 ITGAL; integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) hsa:3689 ITGB2; integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) hsa:4629 MYH11; myosin, heavy chain 11, smooth muscle hsa:57644 MYH7B; myosin, heavy chain 7B, cardiac muscle, beta hsa:5879 RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) hsa:5880 RAC2; ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)

hsa04020 Calcium signaling pathway - Homo sapiens (human) (25)

hsa:115 ADCY9; adenylate cyclase 9 (EC:4.6.1.1) hsa:185 AGTR1; angiotensin II receptor, type 1 hsa:886 CCKAR; cholecystokinin A receptor hsa:887 CCKBR; cholecystokinin B receptor hsa:1129 CHRM2; cholinergic receptor, muscarinic 2 hsa:1956 EGFR; epidermal growth factor receptor (EC:2.7.10.1) hsa:2064 ERBB2; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (EC:2.7.10.1) hsa:2149 F2R; coagulation factor II (thrombin) receptor hsa:2778 GNAS; GNAS complex locus hsa:2902 GRIN1; glutamate receptor, ionotropic, N-methyl D-aspartate 1 hsa:2903 GRIN2A; glutamate receptor, ionotropic, N-methyl D-aspartate 2A hsa:2905 GRIN2C; glutamate receptor, ionotropic, N-methyl D-aspartate 2C hsa:2906 GRIN2D; glutamate receptor, ionotropic, N-methyl D-aspartate 2D hsa:3274 HRH2; histamine receptor H2 hsa:3709 ITPR2; inositol 1,4,5-trisphosphate receptor, type 2 hsa:4638 MYLK; myosin light chain kinase (EC:2.7.11.18) hsa:4842 NOS1; nitric oxide synthase 1 (neuronal) (EC:1.14.13.39) hsa:4843 NOS2; nitric oxide synthase 2, inducible (EC:1.14.13.39) hsa:5330 PLCB2; phospholipase C, beta 2 (EC:3.1.4.11) hsa:5332 PLCB4; phospholipase C, beta 4 (EC:3.1.4.11) hsa:51196 PLCE1; phospholipase C, epsilon 1 (EC:3.1.4.11) hsa:5335 PLCG1; phospholipase C, gamma 1 (EC:3.1.4.11) hsa:5530 PPP3CA; protein phosphatase 3, catalytic subunit, alpha isozyme (EC:3.1.3.16) hsa:5578 PRKCA; protein kinase C, alpha (EC:2.7.11.13) hsa:6263 RYR3; ryanodine receptor 3

hsa05223 Non-small cell lung cancer - Homo sapiens (human) (25)

hsa:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) hsa:572 BAD; BCL2-associated agonist of cell death hsa:673 BRAF; v-raf murine sarcoma viral oncogene homolog B (EC:2.7.11.1) hsa:842 CASP9; caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) hsa:595 CCND1; cyclin D1 hsa:1019 CDK4; cyclin-dependent kinase 4 (EC:2.7.11.22) hsa:1029 CDKN2A; cyclin-dependent kinase inhibitor 2A hsa:1869 E2F1; E2F transcription factor 1 hsa:1870 E2F2; E2F transcription factor 2 hsa:1950 EGF; epidermal growth factor hsa:1956 EGFR; epidermal growth factor receptor (EC:2.7.10.1) hsa:2064 ERBB2; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (EC:2.7.10.1) hsa:2885 GRB2; growth factor receptor-bound protein 2 hsa:3845 KRAS; Kirsten rat sarcoma viral oncogene homolog hsa:5604 MAP2K1; mitogen-activated protein kinase kinase 1 (EC:2.7.12.2) hsa:5594 MAPK1; mitogen-activated protein kinase 1 (EC:2.7.11.24) hsa:5595 MAPK3; mitogen-activated protein kinase 3 (EC:2.7.11.24) hsa:4893 NRAS; neuroblastoma RAS viral (v-ras) oncogene homolog hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha) hsa:5335 PLCG1; phospholipase C, gamma 1 (EC:3.1.4.11) hsa:5578 PRKCA; protein kinase C, alpha (EC:2.7.11.13) hsa:5894 RAF1; v-raf-1 murine leukemia viral oncogene homolog 1 (EC:2.7.11.1) hsa:6654 SOS1; son of sevenless homolog 1 (Drosophila) hsa:7039 TGFA; transforming growth factor, alpha hsa:7157 TP53; tumor protein p53

hsa00330 Arginine and proline metabolism - Homo sapiens (human) (25)

cpd:C00011 CO2 cpd:C00014 Ammonia cpd:C00025 L-Glutamate cpd:C00062 L-Arginine cpd:C00064 L-Glutamine cpd:C00077 L-Ornithine cpd:C00086 Urea cpd:C00179 Agmatine cpd:C00315 Spermidine cpd:C00533 Nitric oxide cpd:C00750 Spermine hsa:79814 AGMAT; agmatine ureohydrolase (agmatinase) (EC:3.5.3.11) hsa:262 AMD1; adenosylmethionine decarboxylase 1 (EC:4.1.1.50) hsa:383 ARG1; arginase 1 (EC:3.5.3.1) hsa:384 ARG2; arginase 2 (EC:3.5.3.1) hsa:1152 CKB; creatine kinase, brain (EC:2.7.3.2) hsa:2628 GATM; glycine amidinotransferase (L-arginine:glycine amidinotransferase) (EC:2.1.4.1) hsa:4128 MAOA; monoamine oxidase A (EC:1.4.3.4) hsa:4842 NOS1; nitric oxide synthase 1 (neuronal) (EC:1.14.13.39) hsa:4843 NOS2; nitric oxide synthase 2, inducible (EC:1.14.13.39) hsa:4942 OAT; ornithine aminotransferase (EC:2.6.1.13) hsa:4953 ODC1; ornithine decarboxylase 1 (EC:4.1.1.17) hsa:5009 OTC; ornithine carbamoyltransferase (EC:2.1.3.3) hsa:5033 P4HA1; prolyl 4-hydroxylase, alpha polypeptide I (EC:1.14.11.2) hsa:6611 SMS; spermine synthase (EC:2.5.1.22)

hsa05016 Huntington's disease - Homo sapiens (human) (25)

cpd:C00025 L-Glutamate hsa:517 ATP5G2; ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9) hsa:581 BAX; BCL2-associated X protein hsa:836 CASP3; caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) hsa:841 CASP8; caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) hsa:842 CASP9; caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) hsa:4512 COX1; cytochrome c oxidase subunit I hsa:1385 CREB1; cAMP responsive element binding protein 1 hsa:9586 CREB5; cAMP responsive element binding protein 5 hsa:54205 CYCS; cytochrome c, somatic hsa:1742 DLG4; discs, large homolog 4 (Drosophila) hsa:2902 GRIN1; glutamate receptor, ionotropic, N-methyl D-aspartate 1 hsa:2904 GRIN2B; glutamate receptor, ionotropic, N-methyl D-aspartate 2B hsa:3064 HTT; huntingtin hsa:4697 NDUFA4; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4, 9kDa (EC:1.6.5.3 1.6.99.3) hsa:4725 NDUFS5; NADH dehydrogenase (ubiquinone) Fe-S protein 5, 15kDa (NADH-coenzyme Q reductase) hsa:4729 NDUFV2; NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa (EC:1.6.5.3 1.6.99.3) hsa:5330 PLCB2; phospholipase C, beta 2 (EC:3.1.4.11) hsa:5332 PLCB4; phospholipase C, beta 4 (EC:3.1.4.11) hsa:5468 PPARG; peroxisome proliferator-activated receptor gamma hsa:6389 SDHA; succinate dehydrogenase complex, subunit A, flavoprotein (Fp) (EC:1.3.5.1) hsa:6390 SDHB; succinate dehydrogenase complex, subunit B, iron sulfur (Ip) (EC:1.3.5.1) hsa:6391 SDHC; succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa hsa:6392 SDHD; succinate dehydrogenase complex, subunit D, integral membrane protein hsa:7157 TP53; tumor protein p53

hsa05100 Bacterial invasion of epithelial cells - Homo sapiens (human) (25)

hsa:10093 ARPC4; actin related protein 2/3 complex, subunit 4, 20kDa hsa:857 CAV1; caveolin 1, caveolae protein, 22kDa hsa:23607 CD2AP; CD2-associated protein hsa:998 CDC42; cell division cycle 42 hsa:999 CDH1; cadherin 1, type 1, E-cadherin (epithelial) hsa:1398 CRK; v-crk avian sarcoma virus CT10 oncogene homolog hsa:1399 CRKL; v-crk avian sarcoma virus CT10 oncogene homolog-like hsa:1499 CTNNB1; catenin (cadherin-associated protein), beta 1, 88kDa hsa:2017 CTTN; cortactin hsa:1793 DOCK1; dedicator of cytokinesis 1 hsa:2335 FN1; fibronectin 1 hsa:2549 GAB1; GRB2-associated binding protein 1 hsa:3611 ILK; integrin-linked kinase (EC:2.7.11.1) hsa:3678 ITGA5; integrin, alpha 5 (fibronectin receptor, alpha polypeptide) hsa:3688 ITGB1; integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) hsa:4233 MET; met proto-oncogene (EC:2.7.10.1) hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha) hsa:5747 PTK2; protein tyrosine kinase 2 (EC:2.7.10.2) hsa:5829 PXN; paxillin hsa:5879 RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) hsa:387 RHOA; ras homolog family member A hsa:6714 SRC; v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (EC:2.7.10.2) hsa:7414 VCL; vinculin hsa:8936 WASF1; WAS protein family, member 1 hsa:8976 WASL; Wiskott-Aldrich syndrome-like

hsa04728 Dopaminergic synapse - Homo sapiens (human) (25)

cpd:C00082 L-Tyrosine cpd:C00355 3,4-Dihydroxy-L-phenylalanine cpd:C03758 Dopamine hsa:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) hsa:406 ARNTL; aryl hydrocarbon receptor nuclear translocator-like hsa:1386 ATF2; activating transcription factor 2 hsa:1312 COMT; catechol-O-methyltransferase (EC:2.1.1.6) hsa:1385 CREB1; cAMP responsive element binding protein 1 hsa:9586 CREB5; cAMP responsive element binding protein 5 hsa:1644 DDC; dopa decarboxylase (aromatic L-amino acid decarboxylase) (EC:4.1.1.28) hsa:2353 FOS; FBJ murine osteosarcoma viral oncogene homolog hsa:2778 GNAS; GNAS complex locus hsa:2783 GNB2; guanine nucleotide binding protein (G protein), beta polypeptide 2 hsa:2903 GRIN2A; glutamate receptor, ionotropic, N-methyl D-aspartate 2A hsa:2904 GRIN2B; glutamate receptor, ionotropic, N-methyl D-aspartate 2B hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26) hsa:3709 ITPR2; inositol 1,4,5-trisphosphate receptor, type 2 hsa:3798 KIF5A; kinesin family member 5A hsa:4128 MAOA; monoamine oxidase A (EC:1.4.3.4) hsa:1432 MAPK14; mitogen-activated protein kinase 14 (EC:2.7.11.24) hsa:5599 MAPK8; mitogen-activated protein kinase 8 (EC:2.7.11.24) hsa:5330 PLCB2; phospholipase C, beta 2 (EC:3.1.4.11) hsa:5332 PLCB4; phospholipase C, beta 4 (EC:3.1.4.11) hsa:5530 PPP3CA; protein phosphatase 3, catalytic subunit, alpha isozyme (EC:3.1.3.16) hsa:5578 PRKCA; protein kinase C, alpha (EC:2.7.11.13)

hsa05221 Acute myeloid leukemia - Homo sapiens (human) (24)

hsa:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) hsa:572 BAD; BCL2-associated agonist of cell death hsa:673 BRAF; v-raf murine sarcoma viral oncogene homolog B (EC:2.7.11.1) hsa:595 CCND1; cyclin D1 hsa:1147 CHUK; conserved helix-loop-helix ubiquitous kinase (EC:2.7.11.10) hsa:2885 GRB2; growth factor receptor-bound protein 2 hsa:3551 IKBKB; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta (EC:2.7.11.10) hsa:8517 IKBKG; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma hsa:3845 KRAS; Kirsten rat sarcoma viral oncogene homolog hsa:51176 LEF1; lymphoid enhancer-binding factor 1 hsa:5604 MAP2K1; mitogen-activated protein kinase kinase 1 (EC:2.7.12.2) hsa:5594 MAPK1; mitogen-activated protein kinase 1 (EC:2.7.11.24) hsa:5595 MAPK3; mitogen-activated protein kinase 3 (EC:2.7.11.24) hsa:4609 MYC; v-myc avian myelocytomatosis viral oncogene homolog hsa:4790 NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 hsa:4893 NRAS; neuroblastoma RAS viral (v-ras) oncogene homolog hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha) hsa:5467 PPARD; peroxisome proliferator-activated receptor delta hsa:5894 RAF1; v-raf-1 murine leukemia viral oncogene homolog 1 (EC:2.7.11.1) hsa:5970 RELA; v-rel avian reticuloendotheliosis viral oncogene homolog A hsa:6654 SOS1; son of sevenless homolog 1 (Drosophila) hsa:6774 STAT3; signal transducer and activator of transcription 3 (acute-phase response factor) hsa:6776 STAT5A; signal transducer and activator of transcription 5A hsa:6777 STAT5B; signal transducer and activator of transcription 5B

hsa04370 VEGF signaling pathway - Homo sapiens (human) (24)

cpd:C00533 Nitric oxide hsa:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) hsa:572 BAD; BCL2-associated agonist of cell death hsa:842 CASP9; caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) hsa:998 CDC42; cell division cycle 42 hsa:3845 KRAS; Kirsten rat sarcoma viral oncogene homolog hsa:5604 MAP2K1; mitogen-activated protein kinase kinase 1 (EC:2.7.12.2) hsa:5594 MAPK1; mitogen-activated protein kinase 1 (EC:2.7.11.24) hsa:1432 MAPK14; mitogen-activated protein kinase 14 (EC:2.7.11.24) hsa:5595 MAPK3; mitogen-activated protein kinase 3 (EC:2.7.11.24) hsa:4893 NRAS; neuroblastoma RAS viral (v-ras) oncogene homolog hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha) hsa:5335 PLCG1; phospholipase C, gamma 1 (EC:3.1.4.11) hsa:5530 PPP3CA; protein phosphatase 3, catalytic subunit, alpha isozyme (EC:3.1.3.16) hsa:5578 PRKCA; protein kinase C, alpha (EC:2.7.11.13) hsa:5743 PTGS2; prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) hsa:5747 PTK2; protein tyrosine kinase 2 (EC:2.7.10.2) hsa:5829 PXN; paxillin hsa:5879 RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) hsa:5880 RAC2; ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) hsa:5894 RAF1; v-raf-1 murine leukemia viral oncogene homolog 1 (EC:2.7.11.1) hsa:9047 SH2D2A; SH2 domain containing 2A hsa:6714 SRC; v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (EC:2.7.10.2) hsa:7422 VEGFA; vascular endothelial growth factor A

hsa05144 Malaria - Homo sapiens (human) (24)

cpd:C00533 Nitric oxide hsa:6347 CCL2; chemokine (C-C motif) ligand 2 hsa:948 CD36; CD36 molecule (thrombospondin receptor) hsa:1378 CR1; complement component (3b/4b) receptor 1 (Knops blood group) hsa:3039 HBA1; hemoglobin, alpha 1 hsa:3383 ICAM1; intercellular adhesion molecule 1 hsa:3458 IFNG; interferon, gamma hsa:3586 IL10; interleukin 10 hsa:3553 IL1B; interleukin 1, beta hsa:3569 IL6; interleukin 6 (interferon, beta 2) hsa:3576 IL8; interleukin 8 hsa:3683 ITGAL; integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) hsa:3689 ITGB2; integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) hsa:4035 LRP1; low density lipoprotein receptor-related protein 1 hsa:4233 MET; met proto-oncogene (EC:2.7.10.1) hsa:6403 SELP; selectin P (granule membrane protein 140kDa, antigen CD62) hsa:7040 TGFB1; transforming growth factor, beta 1 hsa:7042 TGFB2; transforming growth factor, beta 2 hsa:7057 THBS1; thrombospondin 1 hsa:7097 TLR2; toll-like receptor 2 hsa:7099 TLR4; toll-like receptor 4 hsa:54106 TLR9; toll-like receptor 9 hsa:7124 TNF; tumor necrosis factor hsa:7412 VCAM1; vascular cell adhesion molecule 1

hsa05030 Cocaine addiction - Homo sapiens (human) (24)

cpd:C00025 L-Glutamate cpd:C00027 Hydrogen peroxide cpd:C00082 L-Tyrosine cpd:C00355 3,4-Dihydroxy-L-phenylalanine cpd:C03758 Dopamine hsa:1386 ATF2; activating transcription factor 2 hsa:1020 CDK5; cyclin-dependent kinase 5 (EC:2.7.11.22) hsa:1385 CREB1; cAMP responsive element binding protein 1 hsa:9586 CREB5; cAMP responsive element binding protein 5 hsa:1644 DDC; dopa decarboxylase (aromatic L-amino acid decarboxylase) (EC:4.1.1.28) hsa:1742 DLG4; discs, large homolog 4 (Drosophila) hsa:2778 GNAS; GNAS complex locus hsa:2902 GRIN1; glutamate receptor, ionotropic, N-methyl D-aspartate 1 hsa:2903 GRIN2A; glutamate receptor, ionotropic, N-methyl D-aspartate 2A hsa:2904 GRIN2B; glutamate receptor, ionotropic, N-methyl D-aspartate 2B hsa:2905 GRIN2C; glutamate receptor, ionotropic, N-methyl D-aspartate 2C hsa:2906 GRIN2D; glutamate receptor, ionotropic, N-methyl D-aspartate 2D hsa:116443 GRIN3A; glutamate receptor, ionotropic, N-methyl-D-aspartate 3A hsa:116444 GRIN3B; glutamate receptor, ionotropic, N-methyl-D-aspartate 3B hsa:3725 JUN; jun proto-oncogene hsa:4128 MAOA; monoamine oxidase A (EC:1.4.3.4) hsa:4790 NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 hsa:5970 RELA; v-rel avian reticuloendotheliosis viral oncogene homolog A hsa:8787 RGS9; regulator of G-protein signaling 9

hsa05322 Systemic lupus erythematosus - Homo sapiens (human) (23)

cpd:C00027 Hydrogen peroxide cpd:C02737 Phosphatidylserine hsa:713 C1QB; complement component 1, q subcomponent, B chain hsa:717 C2; complement component 2 (EC:3.4.21.43) hsa:718 C3; complement component 3 (EC:3.4.21.43) hsa:720 C4A; complement component 4A (Rodgers blood group) hsa:731 C8A; complement component 8, alpha polypeptide hsa:2903 GRIN2A; glutamate receptor, ionotropic, N-methyl D-aspartate 2A hsa:2904 GRIN2B; glutamate receptor, ionotropic, N-methyl D-aspartate 2B hsa:3014 H2AFX; H2A histone family, member X hsa:8334 HIST1H2AC; histone cluster 1, H2ac hsa:8329 HIST1H2AI; histone cluster 1, H2ai hsa:8356 HIST1H3J; histone cluster 1, H3j hsa:3108 HLA-DMA; major histocompatibility complex, class II, DM alpha hsa:3117 HLA-DQA1; major histocompatibility complex, class II, DQ alpha 1 hsa:3119 HLA-DQB1; major histocompatibility complex, class II, DQ beta 1 hsa:3122 HLA-DRA; major histocompatibility complex, class II, DR alpha hsa:3125 HLA-DRB3; major histocompatibility complex, class II, DR beta 3 hsa:3127 HLA-DRB5; major histocompatibility complex, class II, DR beta 5 hsa:3458 IFNG; interferon, gamma hsa:3586 IL10; interleukin 10 hsa:6632 SNRPD1; small nuclear ribonucleoprotein D1 polypeptide 16kDa hsa:7124 TNF; tumor necrosis factor

hsa04971 Gastric acid secretion - Homo sapiens (human) (23)

cpd:C00011 CO2 cpd:C00080 H+ cpd:C00388 Histamine cpd:C00698 Cl- hsa:115 ADCY9; adenylate cyclase 9 (EC:4.6.1.1) hsa:495 ATP4A; ATPase, H+/K+ exchanging, alpha polypeptide (EC:3.6.3.10) hsa:760 CA2; carbonic anhydrase II (EC:4.2.1.1) hsa:887 CCKBR; cholecystokinin B receptor hsa:1080 CFTR; cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) (EC:3.6.3.49) hsa:7430 EZR; ezrin hsa:2520 GAST; gastrin hsa:2778 GNAS; GNAS complex locus hsa:3274 HRH2; histamine receptor H2 hsa:3709 ITPR2; inositol 1,4,5-trisphosphate receptor, type 2 hsa:3758 KCNJ1; potassium inwardly-rectifying channel, subfamily J, member 1 hsa:3784 KCNQ1; potassium voltage-gated channel, KQT-like subfamily, member 1 hsa:4638 MYLK; myosin light chain kinase (EC:2.7.11.18) hsa:5330 PLCB2; phospholipase C, beta 2 (EC:3.1.4.11) hsa:5332 PLCB4; phospholipase C, beta 4 (EC:3.1.4.11) hsa:5578 PRKCA; protein kinase C, alpha (EC:2.7.11.13) hsa:6522 SLC4A2; solute carrier family 4 (anion exchanger), member 2 hsa:6750 SST; somatostatin hsa:6752 SSTR2; somatostatin receptor 2

hsa04622 RIG-I-like receptor signaling pathway - Homo sapiens (human) (23)

hsa:9140 ATG12; autophagy related 12 hsa:9474 ATG5; autophagy related 5 hsa:841 CASP8; caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) hsa:1147 CHUK; conserved helix-loop-helix ubiquitous kinase (EC:2.7.11.10) hsa:3627 CXCL10; chemokine (C-X-C motif) ligand 10 hsa:23586 DDX58; DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 (EC:3.6.4.13) hsa:64135 IFIH1; interferon induced with helicase C domain 1 (EC:3.6.4.13) hsa:3439 IFNA1; interferon, alpha 1 hsa:3445 IFNA8; interferon, alpha 8 hsa:3551 IKBKB; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta (EC:2.7.11.10) hsa:9641 IKBKE; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon (EC:2.7.11.10) hsa:8517 IKBKG; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma hsa:3576 IL8; interleukin 8 hsa:4214 MAP3K1; mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase (EC:2.7.11.25) hsa:6885 MAP3K7; mitogen-activated protein kinase kinase kinase 7 (EC:2.7.11.25) hsa:1432 MAPK14; mitogen-activated protein kinase 14 (EC:2.7.11.24) hsa:5599 MAPK8; mitogen-activated protein kinase 8 (EC:2.7.11.24) hsa:4790 NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 hsa:4792 NFKBIA; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha hsa:5970 RELA; v-rel avian reticuloendotheliosis viral oncogene homolog A hsa:7124 TNF; tumor necrosis factor hsa:8717 TRADD; TNFRSF1A-associated via death domain hsa:7189 TRAF6; TNF receptor-associated factor 6, E3 ubiquitin protein ligase

hsa04724 Glutamatergic synapse - Homo sapiens (human) (23)

cpd:C00025 L-Glutamate cpd:C00064 L-Glutamine hsa:115 ADCY9; adenylate cyclase 9 (EC:4.6.1.1) hsa:1742 DLG4; discs, large homolog 4 (Drosophila) hsa:2778 GNAS; GNAS complex locus hsa:2783 GNB2; guanine nucleotide binding protein (G protein), beta polypeptide 2 hsa:2902 GRIN1; glutamate receptor, ionotropic, N-methyl D-aspartate 1 hsa:2903 GRIN2A; glutamate receptor, ionotropic, N-methyl D-aspartate 2A hsa:2904 GRIN2B; glutamate receptor, ionotropic, N-methyl D-aspartate 2B hsa:2905 GRIN2C; glutamate receptor, ionotropic, N-methyl D-aspartate 2C hsa:2906 GRIN2D; glutamate receptor, ionotropic, N-methyl D-aspartate 2D hsa:116443 GRIN3A; glutamate receptor, ionotropic, N-methyl-D-aspartate 3A hsa:116444 GRIN3B; glutamate receptor, ionotropic, N-methyl-D-aspartate 3B hsa:3709 ITPR2; inositol 1,4,5-trisphosphate receptor, type 2 hsa:5594 MAPK1; mitogen-activated protein kinase 1 (EC:2.7.11.24) hsa:5595 MAPK3; mitogen-activated protein kinase 3 (EC:2.7.11.24) hsa:5330 PLCB2; phospholipase C, beta 2 (EC:3.1.4.11) hsa:5332 PLCB4; phospholipase C, beta 4 (EC:3.1.4.11) hsa:5337 PLD1; phospholipase D1, phosphatidylcholine-specific (EC:3.1.4.4) hsa:5530 PPP3CA; protein phosphatase 3, catalytic subunit, alpha isozyme (EC:3.1.3.16) hsa:5578 PRKCA; protein kinase C, alpha (EC:2.7.11.13) hsa:6505 SLC1A1; solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 hsa:54407 SLC38A2; solute carrier family 38, member 2

hsa04115 p53 signaling pathway - Homo sapiens (human) (23)

hsa:472 ATM; ataxia telangiectasia mutated (EC:2.7.11.1) hsa:581 BAX; BCL2-associated X protein hsa:637 BID; BH3 interacting domain death agonist hsa:836 CASP3; caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) hsa:841 CASP8; caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) hsa:842 CASP9; caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) hsa:595 CCND1; cyclin D1 hsa:1019 CDK4; cyclin-dependent kinase 4 (EC:2.7.11.22) hsa:1026 CDKN1A; cyclin-dependent kinase inhibitor 1A (p21, Cip1) hsa:1029 CDKN2A; cyclin-dependent kinase inhibitor 2A hsa:54205 CYCS; cytochrome c, somatic hsa:355 FAS; Fas cell surface death receptor hsa:1647 GADD45A; growth arrest and DNA-damage-inducible, alpha hsa:3479 IGF1; insulin-like growth factor 1 (somatomedin C) hsa:3486 IGFBP3; insulin-like growth factor binding protein 3 hsa:4193 MDM2; MDM2 oncogene, E3 ubiquitin protein ligase hsa:5366 PMAIP1; phorbol-12-myristate-13-acetate-induced protein 1 hsa:5728 PTEN; phosphatase and tensin homolog (EC:3.1.3.67 3.1.3.16 3.1.3.48) hsa:5054 SERPINE1; serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 hsa:83667 SESN2; sestrin 2 hsa:7057 THBS1; thrombospondin 1 hsa:7157 TP53; tumor protein p53 hsa:7161 TP73; tumor protein p73

hsa05031 Amphetamine addiction - Homo sapiens (human) (22)

cpd:C00025 L-Glutamate cpd:C00027 Hydrogen peroxide cpd:C00082 L-Tyrosine cpd:C00355 3,4-Dihydroxy-L-phenylalanine cpd:C03758 Dopamine hsa:1386 ATF2; activating transcription factor 2 hsa:1385 CREB1; cAMP responsive element binding protein 1 hsa:9586 CREB5; cAMP responsive element binding protein 5 hsa:1644 DDC; dopa decarboxylase (aromatic L-amino acid decarboxylase) (EC:4.1.1.28) hsa:2353 FOS; FBJ murine osteosarcoma viral oncogene homolog hsa:2778 GNAS; GNAS complex locus hsa:2902 GRIN1; glutamate receptor, ionotropic, N-methyl D-aspartate 1 hsa:2903 GRIN2A; glutamate receptor, ionotropic, N-methyl D-aspartate 2A hsa:2904 GRIN2B; glutamate receptor, ionotropic, N-methyl D-aspartate 2B hsa:2905 GRIN2C; glutamate receptor, ionotropic, N-methyl D-aspartate 2C hsa:2906 GRIN2D; glutamate receptor, ionotropic, N-methyl D-aspartate 2D hsa:116443 GRIN3A; glutamate receptor, ionotropic, N-methyl-D-aspartate 3A hsa:116444 GRIN3B; glutamate receptor, ionotropic, N-methyl-D-aspartate 3B hsa:3725 JUN; jun proto-oncogene hsa:4128 MAOA; monoamine oxidase A (EC:1.4.3.4) hsa:5530 PPP3CA; protein phosphatase 3, catalytic subunit, alpha isozyme (EC:3.1.3.16) hsa:5578 PRKCA; protein kinase C, alpha (EC:2.7.11.13)

hsa04350 TGF-beta signaling pathway - Homo sapiens (human) (22)

hsa:90 ACVR1; activin A receptor, type I (EC:2.7.11.30) hsa:650 BMP2; bone morphogenetic protein 2 hsa:652 BMP4; bone morphogenetic protein 4 hsa:655 BMP7; bone morphogenetic protein 7 hsa:8200 GDF5; growth differentiation factor 5 hsa:3398 ID2; inhibitor of DNA binding 2, dominant negative helix-loop-helix protein hsa:3458 IFNG; interferon, gamma hsa:3624 INHBA; inhibin, beta A hsa:83729 INHBE; inhibin, beta E hsa:5594 MAPK1; mitogen-activated protein kinase 1 (EC:2.7.11.24) hsa:5595 MAPK3; mitogen-activated protein kinase 3 (EC:2.7.11.24) hsa:4609 MYC; v-myc avian myelocytomatosis viral oncogene homolog hsa:5933 RBL1; retinoblastoma-like 1 (p107) hsa:387 RHOA; ras homolog family member A hsa:4090 SMAD5; SMAD family member 5 hsa:4092 SMAD7; SMAD family member 7 hsa:4093 SMAD9; SMAD family member 9 hsa:7040 TGFB1; transforming growth factor, beta 1 hsa:7042 TGFB2; transforming growth factor, beta 2 hsa:7057 THBS1; thrombospondin 1 hsa:7124 TNF; tumor necrosis factor hsa:9372 ZFYVE9; zinc finger, FYVE domain containing 9

hsa04725 Cholinergic synapse - Homo sapiens (human) (22)

cpd:C00033 Acetate hsa:115 ADCY9; adenylate cyclase 9 (EC:4.6.1.1) hsa:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) hsa:596 BCL2; B-cell CLL/lymphoma 2 hsa:1129 CHRM2; cholinergic receptor, muscarinic 2 hsa:1385 CREB1; cAMP responsive element binding protein 1 hsa:9586 CREB5; cAMP responsive element binding protein 5 hsa:2353 FOS; FBJ murine osteosarcoma viral oncogene homolog hsa:2534 FYN; FYN oncogene related to SRC, FGR, YES (EC:2.7.10.2) hsa:2783 GNB2; guanine nucleotide binding protein (G protein), beta polypeptide 2 hsa:3709 ITPR2; inositol 1,4,5-trisphosphate receptor, type 2 hsa:3717 JAK2; Janus kinase 2 (EC:2.7.10.2) hsa:3784 KCNQ1; potassium voltage-gated channel, KQT-like subfamily, member 1 hsa:3845 KRAS; Kirsten rat sarcoma viral oncogene homolog hsa:5604 MAP2K1; mitogen-activated protein kinase kinase 1 (EC:2.7.12.2) hsa:5594 MAPK1; mitogen-activated protein kinase 1 (EC:2.7.11.24) hsa:5595 MAPK3; mitogen-activated protein kinase 3 (EC:2.7.11.24) hsa:4893 NRAS; neuroblastoma RAS viral (v-ras) oncogene homolog hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha) hsa:5330 PLCB2; phospholipase C, beta 2 (EC:3.1.4.11) hsa:5332 PLCB4; phospholipase C, beta 4 (EC:3.1.4.11) hsa:5578 PRKCA; protein kinase C, alpha (EC:2.7.11.13)

hsa05130 Pathogenic Escherichia coli infection - Homo sapiens (human) (21)

hsa:25 ABL1; c-abl oncogene 1, non-receptor tyrosine kinase (EC:2.7.10.2) hsa:10093 ARPC4; actin related protein 2/3 complex, subunit 4, 20kDa hsa:929 CD14; CD14 molecule hsa:998 CDC42; cell division cycle 42 hsa:999 CDH1; cadherin 1, type 1, E-cadherin (epithelial) hsa:1499 CTNNB1; catenin (cadherin-associated protein), beta 1, 88kDa hsa:2017 CTTN; cortactin hsa:7430 EZR; ezrin hsa:2534 FYN; FYN oncogene related to SRC, FGR, YES (EC:2.7.10.2) hsa:3688 ITGB1; integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) hsa:23643 LY96; lymphocyte antigen 96 hsa:4691 NCL; nucleolin hsa:100506658 OCLN; occludin (EC:2.1.1.67) hsa:5578 PRKCA; protein kinase C, alpha (EC:2.7.11.13) hsa:387 RHOA; ras homolog family member A hsa:7099 TLR4; toll-like receptor 4 hsa:7100 TLR5; toll-like receptor 5 hsa:10376 TUBA1B; tubulin, alpha 1b hsa:203068 TUBB; tubulin, beta class I hsa:8976 WASL; Wiskott-Aldrich syndrome-like hsa:10971 YWHAQ; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide

hsa04713 Circadian entrainment - Homo sapiens (human) (21)

cpd:C00025 L-Glutamate cpd:C00533 Nitric oxide cpd:C01598 Melatonin hsa:115 ADCY9; adenylate cyclase 9 (EC:4.6.1.1) hsa:1385 CREB1; cAMP responsive element binding protein 1 hsa:2353 FOS; FBJ murine osteosarcoma viral oncogene homolog hsa:2778 GNAS; GNAS complex locus hsa:2783 GNB2; guanine nucleotide binding protein (G protein), beta polypeptide 2 hsa:2902 GRIN1; glutamate receptor, ionotropic, N-methyl D-aspartate 1 hsa:2903 GRIN2A; glutamate receptor, ionotropic, N-methyl D-aspartate 2A hsa:2904 GRIN2B; glutamate receptor, ionotropic, N-methyl D-aspartate 2B hsa:2905 GRIN2C; glutamate receptor, ionotropic, N-methyl D-aspartate 2C hsa:2906 GRIN2D; glutamate receptor, ionotropic, N-methyl D-aspartate 2D hsa:5594 MAPK1; mitogen-activated protein kinase 1 (EC:2.7.11.24) hsa:5595 MAPK3; mitogen-activated protein kinase 3 (EC:2.7.11.24) hsa:4842 NOS1; nitric oxide synthase 1 (neuronal) (EC:1.14.13.39) hsa:5330 PLCB2; phospholipase C, beta 2 (EC:3.1.4.11) hsa:5332 PLCB4; phospholipase C, beta 4 (EC:3.1.4.11) hsa:5578 PRKCA; protein kinase C, alpha (EC:2.7.11.13) hsa:9252 RPS6KA5; ribosomal protein S6 kinase, 90kDa, polypeptide 5 (EC:2.7.11.1) hsa:6263 RYR3; ryanodine receptor 3

hsa04920 Adipocytokine signaling pathway - Homo sapiens (human) (21)

cpd:C00195 N-Acylsphingosine hsa:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) hsa:948 CD36; CD36 molecule (thrombospondin receptor) hsa:1147 CHUK; conserved helix-loop-helix ubiquitous kinase (EC:2.7.11.10) hsa:3551 IKBKB; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta (EC:2.7.11.10) hsa:8517 IKBKG; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma hsa:3667 IRS1; insulin receptor substrate 1 hsa:3717 JAK2; Janus kinase 2 (EC:2.7.10.2) hsa:3952 LEP; leptin hsa:5599 MAPK8; mitogen-activated protein kinase 8 (EC:2.7.11.24) hsa:4790 NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 hsa:4792 NFKBIA; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha hsa:5106 PCK2; phosphoenolpyruvate carboxykinase 2 (mitochondrial) (EC:4.1.1.32) hsa:5588 PRKCQ; protein kinase C, theta (EC:2.7.11.13) hsa:5781 PTPN11; protein tyrosine phosphatase, non-receptor type 11 (EC:3.1.3.48) hsa:5970 RELA; v-rel avian reticuloendotheliosis viral oncogene homolog A hsa:6774 STAT3; signal transducer and activator of transcription 3 (acute-phase response factor) hsa:7124 TNF; tumor necrosis factor hsa:7132 TNFRSF1A; tumor necrosis factor receptor superfamily, member 1A hsa:7133 TNFRSF1B; tumor necrosis factor receptor superfamily, member 1B hsa:8717 TRADD; TNFRSF1A-associated via death domain

hsa04610 Complement and coagulation cascades - Homo sapiens (human) (21)

hsa:2 A2M; alpha-2-macroglobulin hsa:713 C1QB; complement component 1, q subcomponent, B chain hsa:717 C2; complement component 2 (EC:3.4.21.43) hsa:718 C3; complement component 3 (EC:3.4.21.43) hsa:720 C4A; complement component 4A (Rodgers blood group) hsa:731 C8A; complement component 8, alpha polypeptide hsa:4179 CD46; CD46 molecule, complement regulatory protein hsa:1604 CD55; CD55 molecule, decay accelerating factor for complement (Cromer blood group) hsa:1361 CPB2; carboxypeptidase B2 (plasma) (EC:3.4.17.20) hsa:1378 CR1; complement component (3b/4b) receptor 1 (Knops blood group) hsa:2147 F2; coagulation factor II (thrombin) (EC:3.4.21.5) hsa:2149 F2R; coagulation factor II (thrombin) receptor hsa:2152 F3; coagulation factor III (thromboplastin, tissue factor) hsa:2244 FGB; fibrinogen beta chain hsa:4153 MBL2; mannose-binding lectin (protein C) 2, soluble hsa:5327 PLAT; plasminogen activator, tissue (EC:3.4.21.68) hsa:5328 PLAU; plasminogen activator, urokinase (EC:3.4.21.73) hsa:5340 PLG; plasminogen (EC:3.4.21.7) hsa:5054 SERPINE1; serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 hsa:710 SERPING1; serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 hsa:7450 VWF; von Willebrand factor

hsa04976 Bile secretion - Homo sapiens (human) (20)

cpd:C00011 CO2 cpd:C00051 Glutathione cpd:C00080 H+ cpd:C00187 Cholesterol cpd:C00315 Spermidine cpd:C00584 Prostaglandin E2 cpd:C00698 Cl- cpd:C00750 Spermine cpd:C02165 Leukotriene B4 cpd:C02166 Leukotriene C4 cpd:C03758 Dopamine hsa:5243 ABCB1; ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) hsa:115 ADCY9; adenylate cyclase 9 (EC:4.6.1.1) hsa:361 AQP4; aquaporin 4 hsa:760 CA2; carbonic anhydrase II (EC:4.2.1.1) hsa:1080 CFTR; cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) (EC:3.6.3.49) hsa:2778 GNAS; GNAS complex locus hsa:3949 LDLR; low density lipoprotein receptor hsa:6522 SLC4A2; solute carrier family 4 (anion exchanger), member 2 hsa:8671 SLC4A4; solute carrier family 4 (sodium bicarbonate cotransporter), member 4

hsa04972 Pancreatic secretion - Homo sapiens (human) (20)

cpd:C00011 CO2 cpd:C00080 H+ cpd:C00698 Cl- hsa:115 ADCY9; adenylate cyclase 9 (EC:4.6.1.1) hsa:760 CA2; carbonic anhydrase II (EC:4.2.1.1) hsa:886 CCKAR; cholecystokinin A receptor hsa:1080 CFTR; cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) (EC:3.6.3.49) hsa:1361 CPB2; carboxypeptidase B2 (plasma) (EC:3.4.17.20) hsa:2778 GNAS; GNAS complex locus hsa:3709 ITPR2; inositol 1,4,5-trisphosphate receptor, type 2 hsa:3784 KCNQ1; potassium voltage-gated channel, KQT-like subfamily, member 1 hsa:5330 PLCB2; phospholipase C, beta 2 (EC:3.1.4.11) hsa:5332 PLCB4; phospholipase C, beta 4 (EC:3.1.4.11) hsa:5578 PRKCA; protein kinase C, alpha (EC:2.7.11.13) hsa:5644 PRSS1; protease, serine, 1 (trypsin 1) (EC:3.4.21.4) hsa:5879 RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) hsa:5906 RAP1A; RAP1A, member of RAS oncogene family hsa:387 RHOA; ras homolog family member A hsa:6522 SLC4A2; solute carrier family 4 (anion exchanger), member 2 hsa:8671 SLC4A4; solute carrier family 4 (sodium bicarbonate cotransporter), member 4

hsa05150 Staphylococcus aureus infection - Homo sapiens (human) (20)

hsa:713 C1QB; complement component 1, q subcomponent, B chain hsa:717 C2; complement component 2 (EC:3.4.21.43) hsa:718 C3; complement component 3 (EC:3.4.21.43) hsa:720 C4A; complement component 4A (Rodgers blood group) hsa:2358 FPR2; formyl peptide receptor 2 hsa:2359 FPR3; formyl peptide receptor 3 hsa:3108 HLA-DMA; major histocompatibility complex, class II, DM alpha hsa:3117 HLA-DQA1; major histocompatibility complex, class II, DQ alpha 1 hsa:3119 HLA-DQB1; major histocompatibility complex, class II, DQ beta 1 hsa:3122 HLA-DRA; major histocompatibility complex, class II, DR alpha hsa:3125 HLA-DRB3; major histocompatibility complex, class II, DR beta 3 hsa:3127 HLA-DRB5; major histocompatibility complex, class II, DR beta 5 hsa:3383 ICAM1; intercellular adhesion molecule 1 hsa:3586 IL10; interleukin 10 hsa:3683 ITGAL; integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) hsa:3684 ITGAM; integrin, alpha M (complement component 3 receptor 3 subunit) hsa:3689 ITGB2; integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) hsa:4153 MBL2; mannose-binding lectin (protein C) 2, soluble hsa:5340 PLG; plasminogen (EC:3.4.21.7) hsa:6403 SELP; selectin P (granule membrane protein 140kDa, antigen CD62)

hsa04270 Vascular smooth muscle contraction - Homo sapiens (human) (20)

cpd:C00533 Nitric oxide hsa:115 ADCY9; adenylate cyclase 9 (EC:4.6.1.1) hsa:185 AGTR1; angiotensin II receptor, type 1 hsa:673 BRAF; v-raf murine sarcoma viral oncogene homolog B (EC:2.7.11.1) hsa:800 CALD1; caldesmon 1 hsa:2778 GNAS; GNAS complex locus hsa:3709 ITPR2; inositol 1,4,5-trisphosphate receptor, type 2 hsa:5604 MAP2K1; mitogen-activated protein kinase kinase 1 (EC:2.7.12.2) hsa:5594 MAPK1; mitogen-activated protein kinase 1 (EC:2.7.11.24) hsa:5595 MAPK3; mitogen-activated protein kinase 3 (EC:2.7.11.24) hsa:4629 MYH11; myosin, heavy chain 11, smooth muscle hsa:4638 MYLK; myosin light chain kinase (EC:2.7.11.18) hsa:5330 PLCB2; phospholipase C, beta 2 (EC:3.1.4.11) hsa:5332 PLCB4; phospholipase C, beta 4 (EC:3.1.4.11) hsa:5578 PRKCA; protein kinase C, alpha (EC:2.7.11.13) hsa:5580 PRKCD; protein kinase C, delta (EC:2.7.10.2 2.7.11.13) hsa:5583 PRKCH; protein kinase C, eta (EC:2.7.11.13) hsa:5588 PRKCQ; protein kinase C, theta (EC:2.7.11.13) hsa:5894 RAF1; v-raf-1 murine leukemia viral oncogene homolog 1 (EC:2.7.11.1) hsa:387 RHOA; ras homolog family member A

hsa04141 Protein processing in endoplasmic reticulum - Homo sapiens (human) (20)

hsa:22926 ATF6; activating transcription factor 6 hsa:4287 ATXN3; ataxin 3 (EC:3.4.19.12) hsa:581 BAX; BCL2-associated X protein hsa:596 BCL2; B-cell CLL/lymphoma 2 hsa:823 CAPN1; calpain 1, (mu/I) large subunit (EC:3.4.22.52) hsa:1649 DDIT3; DNA-damage-inducible transcript 3 hsa:9709 HERPUD1; homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 hsa:3320 HSP90AA1; heat shock protein 90kDa alpha (cytosolic), class A member 1 hsa:3326 HSP90AB1; heat shock protein 90kDa alpha (cytosolic), class B member 1 hsa:7184 HSP90B1; heat shock protein 90kDa beta (Grp94), member 1 hsa:3309 HSPA5; heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) hsa:3312 HSPA8; heat shock 70kDa protein 8 hsa:10808 HSPH1; heat shock 105kDa/110kDa protein 1 hsa:10525 HYOU1; hypoxia up-regulated 1 hsa:5599 MAPK8; mitogen-activated protein kinase 8 (EC:2.7.11.24) hsa:10130 PDIA6; protein disulfide isomerase family A, member 6 (EC:5.3.4.1) hsa:5886 RAD23A; RAD23 homolog A (S. cerevisiae) hsa:6396 SEC13; SEC13 homolog (S. cerevisiae) hsa:7415 VCP; valosin containing protein (EC:3.6.4.6) hsa:7494 XBP1; X-box binding protein 1

hsa04612 Antigen processing and presentation - Homo sapiens (human) (19)

hsa:972 CD74; CD74 molecule, major histocompatibility complex, class II invariant chain hsa:4261 CIITA; class II, major histocompatibility complex, transactivator hsa:1385 CREB1; cAMP responsive element binding protein 1 hsa:3106 HLA-B; major histocompatibility complex, class I, B hsa:3108 HLA-DMA; major histocompatibility complex, class II, DM alpha hsa:3117 HLA-DQA1; major histocompatibility complex, class II, DQ alpha 1 hsa:3119 HLA-DQB1; major histocompatibility complex, class II, DQ beta 1 hsa:3122 HLA-DRA; major histocompatibility complex, class II, DR alpha hsa:3125 HLA-DRB3; major histocompatibility complex, class II, DR beta 3 hsa:3127 HLA-DRB5; major histocompatibility complex, class II, DR beta 5 hsa:3134 HLA-F; major histocompatibility complex, class I, F hsa:3320 HSP90AA1; heat shock protein 90kDa alpha (cytosolic), class A member 1 hsa:3326 HSP90AB1; heat shock protein 90kDa alpha (cytosolic), class B member 1 hsa:3309 HSPA5; heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) hsa:3312 HSPA8; heat shock 70kDa protein 8 hsa:3458 IFNG; interferon, gamma hsa:3806 KIR2DS1; killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 1 hsa:5720 PSME1; proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) hsa:7124 TNF; tumor necrosis factor

hsa04720 Long-term potentiation - Homo sapiens (human) (19)

cpd:C00025 L-Glutamate hsa:673 BRAF; v-raf murine sarcoma viral oncogene homolog B (EC:2.7.11.1) hsa:2902 GRIN1; glutamate receptor, ionotropic, N-methyl D-aspartate 1 hsa:2903 GRIN2A; glutamate receptor, ionotropic, N-methyl D-aspartate 2A hsa:2904 GRIN2B; glutamate receptor, ionotropic, N-methyl D-aspartate 2B hsa:2905 GRIN2C; glutamate receptor, ionotropic, N-methyl D-aspartate 2C hsa:2906 GRIN2D; glutamate receptor, ionotropic, N-methyl D-aspartate 2D hsa:3709 ITPR2; inositol 1,4,5-trisphosphate receptor, type 2 hsa:3845 KRAS; Kirsten rat sarcoma viral oncogene homolog hsa:5604 MAP2K1; mitogen-activated protein kinase kinase 1 (EC:2.7.12.2) hsa:5594 MAPK1; mitogen-activated protein kinase 1 (EC:2.7.11.24) hsa:5595 MAPK3; mitogen-activated protein kinase 3 (EC:2.7.11.24) hsa:4893 NRAS; neuroblastoma RAS viral (v-ras) oncogene homolog hsa:5330 PLCB2; phospholipase C, beta 2 (EC:3.1.4.11) hsa:5332 PLCB4; phospholipase C, beta 4 (EC:3.1.4.11) hsa:5530 PPP3CA; protein phosphatase 3, catalytic subunit, alpha isozyme (EC:3.1.3.16) hsa:5578 PRKCA; protein kinase C, alpha (EC:2.7.11.13) hsa:5894 RAF1; v-raf-1 murine leukemia viral oncogene homolog 1 (EC:2.7.11.1) hsa:5906 RAP1A; RAP1A, member of RAS oncogene family

hsa04916 Melanogenesis - Homo sapiens (human) (19)

cpd:C00082 L-Tyrosine hsa:115 ADCY9; adenylate cyclase 9 (EC:4.6.1.1) hsa:1385 CREB1; cAMP responsive element binding protein 1 hsa:1499 CTNNB1; catenin (cadherin-associated protein), beta 1, 88kDa hsa:1856 DVL2; dishevelled segment polarity protein 2 hsa:1857 DVL3; dishevelled segment polarity protein 3 hsa:2778 GNAS; GNAS complex locus hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26) hsa:3845 KRAS; Kirsten rat sarcoma viral oncogene homolog hsa:51176 LEF1; lymphoid enhancer-binding factor 1 hsa:5604 MAP2K1; mitogen-activated protein kinase kinase 1 (EC:2.7.12.2) hsa:5594 MAPK1; mitogen-activated protein kinase 1 (EC:2.7.11.24) hsa:5595 MAPK3; mitogen-activated protein kinase 3 (EC:2.7.11.24) hsa:4893 NRAS; neuroblastoma RAS viral (v-ras) oncogene homolog hsa:5330 PLCB2; phospholipase C, beta 2 (EC:3.1.4.11) hsa:5332 PLCB4; phospholipase C, beta 4 (EC:3.1.4.11) hsa:5578 PRKCA; protein kinase C, alpha (EC:2.7.11.13) hsa:5894 RAF1; v-raf-1 murine leukemia viral oncogene homolog 1 (EC:2.7.11.1) hsa:7472 WNT2; wingless-type MMTV integration site family member 2

hsa01230 Biosynthesis of amino acids - Homo sapiens (human) (19)

cpd:C00011 CO2 cpd:C00014 Ammonia cpd:C00025 L-Glutamate cpd:C00062 L-Arginine cpd:C00064 L-Glutamine cpd:C00077 L-Ornithine cpd:C00078 L-Tryptophan cpd:C00082 L-Tyrosine cpd:C00155 L-Homocysteine hsa:226 ALDOA; aldolase A, fructose-bisphosphate (EC:4.1.2.13) hsa:230 ALDOC; aldolase C, fructose-bisphosphate (EC:4.1.2.13) hsa:383 ARG1; arginase 1 (EC:3.5.3.1) hsa:384 ARG2; arginase 2 (EC:3.5.3.1) hsa:2023 ENO1; enolase 1, (alpha) (EC:4.2.1.11) hsa:2027 ENO3; enolase 3 (beta, muscle) (EC:4.2.1.11) hsa:5009 OTC; ornithine carbamoyltransferase (EC:2.1.3.3) hsa:29968 PSAT1; phosphoserine aminotransferase 1 (EC:2.6.1.52) hsa:5723 PSPH; phosphoserine phosphatase (EC:3.1.3.3) hsa:7167 TPI1; triosephosphate isomerase 1 (EC:5.3.1.1)

hsa05143 African trypanosomiasis - Homo sapiens (human) (19)

cpd:C00078 L-Tryptophan cpd:C00328 L-Kynurenine cpd:C00533 Nitric oxide cpd:C00584 Prostaglandin E2 hsa:335 APOA1; apolipoprotein A-I hsa:2150 F2RL1; coagulation factor II (thrombin) receptor-like 1 hsa:355 FAS; Fas cell surface death receptor hsa:3039 HBA1; hemoglobin, alpha 1 hsa:3383 ICAM1; intercellular adhesion molecule 1 hsa:3458 IFNG; interferon, gamma hsa:3586 IL10; interleukin 10 hsa:3553 IL1B; interleukin 1, beta hsa:3569 IL6; interleukin 6 (interferon, beta 2) hsa:5330 PLCB2; phospholipase C, beta 2 (EC:3.1.4.11) hsa:5332 PLCB4; phospholipase C, beta 4 (EC:3.1.4.11) hsa:5578 PRKCA; protein kinase C, alpha (EC:2.7.11.13) hsa:54106 TLR9; toll-like receptor 9 hsa:7124 TNF; tumor necrosis factor hsa:7412 VCAM1; vascular cell adhesion molecule 1

hsa01200 Carbon metabolism - Homo sapiens (human) (18)

cpd:C00011 CO2 cpd:C00014 Ammonia cpd:C00033 Acetate hsa:226 ALDOA; aldolase A, fructose-bisphosphate (EC:4.1.2.13) hsa:230 ALDOC; aldolase C, fructose-bisphosphate (EC:4.1.2.13) hsa:1738 DLD; dihydrolipoamide dehydrogenase (EC:1.8.1.4) hsa:2023 ENO1; enolase 1, (alpha) (EC:4.2.1.11) hsa:2027 ENO3; enolase 3 (beta, muscle) (EC:4.2.1.11) hsa:2271 FH; fumarate hydratase (EC:4.2.1.2) hsa:2821 GPI; glucose-6-phosphate isomerase (EC:5.3.1.9) hsa:4524 MTHFR; methylenetetrahydrofolate reductase (NAD(P)H) (EC:1.5.1.20) hsa:29968 PSAT1; phosphoserine aminotransferase 1 (EC:2.6.1.52) hsa:5723 PSPH; phosphoserine phosphatase (EC:3.1.3.3) hsa:6389 SDHA; succinate dehydrogenase complex, subunit A, flavoprotein (Fp) (EC:1.3.5.1) hsa:6390 SDHB; succinate dehydrogenase complex, subunit B, iron sulfur (Ip) (EC:1.3.5.1) hsa:6391 SDHC; succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa hsa:6392 SDHD; succinate dehydrogenase complex, subunit D, integral membrane protein hsa:7167 TPI1; triosephosphate isomerase 1 (EC:5.3.1.1)

hsa00190 Oxidative phosphorylation - Homo sapiens (human) (18)

cpd:C00007 Oxygen cpd:C00080 H+ hsa:495 ATP4A; ATPase, H+/K+ exchanging, alpha polypeptide (EC:3.6.3.10) hsa:517 ATP5G2; ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9) hsa:9551 ATP5J2; ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F2 (EC:3.6.1.14) hsa:533 ATP6V0B; ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b (EC:3.6.3.14) hsa:525 ATP6V1B1; ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1 (EC:3.6.3.14) hsa:9296 ATP6V1F; ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F (EC:3.6.3.14) hsa:9550 ATP6V1G1; ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1 (EC:3.6.3.14) hsa:4512 COX1; cytochrome c oxidase subunit I hsa:4697 NDUFA4; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4, 9kDa (EC:1.6.5.3 1.6.99.3) hsa:4725 NDUFS5; NADH dehydrogenase (ubiquinone) Fe-S protein 5, 15kDa (NADH-coenzyme Q reductase) hsa:4729 NDUFV2; NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa (EC:1.6.5.3 1.6.99.3) hsa:6389 SDHA; succinate dehydrogenase complex, subunit A, flavoprotein (Fp) (EC:1.3.5.1) hsa:6390 SDHB; succinate dehydrogenase complex, subunit B, iron sulfur (Ip) (EC:1.3.5.1) hsa:6391 SDHC; succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa hsa:6392 SDHD; succinate dehydrogenase complex, subunit D, integral membrane protein hsa:10312 TCIRG1; T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3 (EC:3.6.3.6)

hsa05012 Parkinson's disease - Homo sapiens (human) (18)

cpd:C00027 Hydrogen peroxide cpd:C00082 L-Tyrosine cpd:C00355 3,4-Dihydroxy-L-phenylalanine cpd:C03758 Dopamine hsa:517 ATP5G2; ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9) hsa:836 CASP3; caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) hsa:842 CASP9; caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) hsa:4512 COX1; cytochrome c oxidase subunit I hsa:54205 CYCS; cytochrome c, somatic hsa:4697 NDUFA4; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4, 9kDa (EC:1.6.5.3 1.6.99.3) hsa:4725 NDUFS5; NADH dehydrogenase (ubiquinone) Fe-S protein 5, 15kDa (NADH-coenzyme Q reductase) hsa:4729 NDUFV2; NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa (EC:1.6.5.3 1.6.99.3) hsa:6389 SDHA; succinate dehydrogenase complex, subunit A, flavoprotein (Fp) (EC:1.3.5.1) hsa:6390 SDHB; succinate dehydrogenase complex, subunit B, iron sulfur (Ip) (EC:1.3.5.1) hsa:6391 SDHC; succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa hsa:6392 SDHD; succinate dehydrogenase complex, subunit D, integral membrane protein hsa:7317 UBA1; ubiquitin-like modifier activating enzyme 1 (EC:6.3.2.19) hsa:7345 UCHL1; ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) (EC:3.4.19.12)

hsa04918 Thyroid hormone synthesis - Homo sapiens (human) (18)

cpd:C00005 NADPH cpd:C00006 NADP+ cpd:C00007 Oxygen cpd:C00027 Hydrogen peroxide cpd:C00051 Glutathione hsa:115 ADCY9; adenylate cyclase 9 (EC:4.6.1.1) hsa:1386 ATF2; activating transcription factor 2 hsa:1385 CREB1; cAMP responsive element binding protein 1 hsa:9586 CREB5; cAMP responsive element binding protein 5 hsa:50506 DUOX2; dual oxidase 2 (EC:1.6.3.1) hsa:2778 GNAS; GNAS complex locus hsa:7184 HSP90B1; heat shock protein 90kDa beta (Grp94), member 1 hsa:3309 HSPA5; heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) hsa:3709 ITPR2; inositol 1,4,5-trisphosphate receptor, type 2 hsa:5330 PLCB2; phospholipase C, beta 2 (EC:3.1.4.11) hsa:5332 PLCB4; phospholipase C, beta 4 (EC:3.1.4.11) hsa:5578 PRKCA; protein kinase C, alpha (EC:2.7.11.13) hsa:7173 TPO; thyroid peroxidase (EC:1.11.1.8)

hsa04974 Protein digestion and absorption - Homo sapiens (human) (18)

cpd:C00011 CO2 cpd:C00014 Ammonia cpd:C00025 L-Glutamate cpd:C00033 Acetate cpd:C00062 L-Arginine cpd:C00064 L-Glutamine cpd:C00078 L-Tryptophan cpd:C00080 H+ cpd:C00082 L-Tyrosine cpd:C00246 Butanoic acid cpd:C00388 Histamine cpd:C01327 Hydrochloric acid hsa:1306 COL15A1; collagen, type XV, alpha 1 hsa:1361 CPB2; carboxypeptidase B2 (plasma) (EC:3.4.17.20) hsa:3784 KCNQ1; potassium voltage-gated channel, KQT-like subfamily, member 1 hsa:5644 PRSS1; protease, serine, 1 (trypsin 1) (EC:3.4.21.4) hsa:6505 SLC1A1; solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 hsa:54407 SLC38A2; solute carrier family 38, member 2

hsa04940 Type I diabetes mellitus - Homo sapiens (human) (17)

cpd:C00027 Hydrogen peroxide cpd:C00533 Nitric oxide hsa:355 FAS; Fas cell surface death receptor hsa:3106 HLA-B; major histocompatibility complex, class I, B hsa:3108 HLA-DMA; major histocompatibility complex, class II, DM alpha hsa:3117 HLA-DQA1; major histocompatibility complex, class II, DQ alpha 1 hsa:3119 HLA-DQB1; major histocompatibility complex, class II, DQ beta 1 hsa:3122 HLA-DRA; major histocompatibility complex, class II, DR alpha hsa:3125 HLA-DRB3; major histocompatibility complex, class II, DR beta 3 hsa:3127 HLA-DRB5; major histocompatibility complex, class II, DR beta 5 hsa:3134 HLA-F; major histocompatibility complex, class I, F hsa:3329 HSPD1; heat shock 60kDa protein 1 (chaperonin) hsa:3458 IFNG; interferon, gamma hsa:3552 IL1A; interleukin 1, alpha hsa:3553 IL1B; interleukin 1, beta hsa:3558 IL2; interleukin 2 hsa:7124 TNF; tumor necrosis factor

hsa05332 Graft-versus-host disease - Homo sapiens (human) (17)

cpd:C00338 Lipopolysaccharide cpd:C00533 Nitric oxide hsa:355 FAS; Fas cell surface death receptor hsa:3106 HLA-B; major histocompatibility complex, class I, B hsa:3108 HLA-DMA; major histocompatibility complex, class II, DM alpha hsa:3117 HLA-DQA1; major histocompatibility complex, class II, DQ alpha 1 hsa:3119 HLA-DQB1; major histocompatibility complex, class II, DQ beta 1 hsa:3122 HLA-DRA; major histocompatibility complex, class II, DR alpha hsa:3125 HLA-DRB3; major histocompatibility complex, class II, DR beta 3 hsa:3127 HLA-DRB5; major histocompatibility complex, class II, DR beta 5 hsa:3134 HLA-F; major histocompatibility complex, class I, F hsa:3458 IFNG; interferon, gamma hsa:3552 IL1A; interleukin 1, alpha hsa:3553 IL1B; interleukin 1, beta hsa:3558 IL2; interleukin 2 hsa:3569 IL6; interleukin 6 (interferon, beta 2) hsa:7124 TNF; tumor necrosis factor

hsa05110 Vibrio cholerae infection - Homo sapiens (human) (17)

cpd:C00014 Ammonia cpd:C00080 H+ cpd:C00698 Cl- cpd:C04911 D-Galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide hsa:115 ADCY9; adenylate cyclase 9 (EC:4.6.1.1) hsa:533 ATP6V0B; ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b (EC:3.6.3.14) hsa:525 ATP6V1B1; ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1 (EC:3.6.3.14) hsa:9296 ATP6V1F; ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F (EC:3.6.3.14) hsa:9550 ATP6V1G1; ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1 (EC:3.6.3.14) hsa:1080 CFTR; cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) (EC:3.6.3.49) hsa:2778 GNAS; GNAS complex locus hsa:3784 KCNQ1; potassium voltage-gated channel, KQT-like subfamily, member 1 hsa:4583 MUC2; mucin 2, oligomeric mucus/gel-forming hsa:5335 PLCG1; phospholipase C, gamma 1 (EC:3.1.4.11) hsa:5578 PRKCA; protein kinase C, alpha (EC:2.7.11.13) hsa:10312 TCIRG1; T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3 (EC:3.6.3.6) hsa:7082 TJP1; tight junction protein 1

hsa04623 Cytosolic DNA-sensing pathway - Homo sapiens (human) (17)

hsa:9447 AIM2; absent in melanoma 2 hsa:6351 CCL4; chemokine (C-C motif) ligand 4 hsa:6352 CCL5; chemokine (C-C motif) ligand 5 hsa:1147 CHUK; conserved helix-loop-helix ubiquitous kinase (EC:2.7.11.10) hsa:3627 CXCL10; chemokine (C-X-C motif) ligand 10 hsa:23586 DDX58; DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 (EC:3.6.4.13) hsa:3439 IFNA1; interferon, alpha 1 hsa:3445 IFNA8; interferon, alpha 8 hsa:3551 IKBKB; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta (EC:2.7.11.10) hsa:9641 IKBKE; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon (EC:2.7.11.10) hsa:8517 IKBKG; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma hsa:3553 IL1B; interleukin 1, beta hsa:3569 IL6; interleukin 6 (interferon, beta 2) hsa:4790 NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 hsa:4792 NFKBIA; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha hsa:10621 POLR3F; polymerase (RNA) III (DNA directed) polypeptide F, 39 kDa hsa:5970 RELA; v-rel avian reticuloendotheliosis viral oncogene homolog A

hsa04970 Salivary secretion - Homo sapiens (human) (17)

cpd:C00011 CO2 cpd:C00080 H+ cpd:C00533 Nitric oxide cpd:C00698 Cl- hsa:115 ADCY9; adenylate cyclase 9 (EC:4.6.1.1) hsa:820 CAMP; cathelicidin antimicrobial peptide hsa:1755 DMBT1; deleted in malignant brain tumors 1 hsa:2778 GNAS; GNAS complex locus hsa:3709 ITPR2; inositol 1,4,5-trisphosphate receptor, type 2 hsa:727897 MUC5B; mucin 5B, oligomeric mucus/gel-forming hsa:4589 MUC7; mucin 7, secreted hsa:4842 NOS1; nitric oxide synthase 1 (neuronal) (EC:1.14.13.39) hsa:5330 PLCB2; phospholipase C, beta 2 (EC:3.1.4.11) hsa:5332 PLCB4; phospholipase C, beta 4 (EC:3.1.4.11) hsa:5578 PRKCA; protein kinase C, alpha (EC:2.7.11.13) hsa:6263 RYR3; ryanodine receptor 3 hsa:6522 SLC4A2; solute carrier family 4 (anion exchanger), member 2

hsa05020 Prion diseases - Homo sapiens (human) (17)

cpd:C00027 Hydrogen peroxide hsa:581 BAX; BCL2-associated X protein hsa:713 C1QB; complement component 1, q subcomponent, B chain hsa:731 C8A; complement component 8, alpha polypeptide hsa:6352 CCL5; chemokine (C-C motif) ligand 5 hsa:1958 EGR1; early growth response 1 hsa:2002 ELK1; ELK1, member of ETS oncogene family hsa:2534 FYN; FYN oncogene related to SRC, FGR, YES (EC:2.7.10.2) hsa:3309 HSPA5; heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) hsa:3552 IL1A; interleukin 1, alpha hsa:3553 IL1B; interleukin 1, beta hsa:3569 IL6; interleukin 6 (interferon, beta 2) hsa:3915 LAMC1; laminin, gamma 1 (formerly LAMB2) hsa:5604 MAP2K1; mitogen-activated protein kinase kinase 1 (EC:2.7.12.2) hsa:5594 MAPK1; mitogen-activated protein kinase 1 (EC:2.7.11.24) hsa:5595 MAPK3; mitogen-activated protein kinase 3 (EC:2.7.11.24) hsa:4685 NCAM2; neural cell adhesion molecule 2

hsa04730 Long-term depression - Homo sapiens (human) (17)

cpd:C00025 L-Glutamate cpd:C00533 Nitric oxide hsa:673 BRAF; v-raf murine sarcoma viral oncogene homolog B (EC:2.7.11.1) hsa:2778 GNAS; GNAS complex locus hsa:3479 IGF1; insulin-like growth factor 1 (somatomedin C) hsa:3709 ITPR2; inositol 1,4,5-trisphosphate receptor, type 2 hsa:3845 KRAS; Kirsten rat sarcoma viral oncogene homolog hsa:4067 LYN; v-yes-1 Yamaguchi sarcoma viral related oncogene homolog (EC:2.7.10.2) hsa:5604 MAP2K1; mitogen-activated protein kinase kinase 1 (EC:2.7.12.2) hsa:5594 MAPK1; mitogen-activated protein kinase 1 (EC:2.7.11.24) hsa:5595 MAPK3; mitogen-activated protein kinase 3 (EC:2.7.11.24) hsa:4842 NOS1; nitric oxide synthase 1 (neuronal) (EC:1.14.13.39) hsa:4893 NRAS; neuroblastoma RAS viral (v-ras) oncogene homolog hsa:5330 PLCB2; phospholipase C, beta 2 (EC:3.1.4.11) hsa:5332 PLCB4; phospholipase C, beta 4 (EC:3.1.4.11) hsa:5578 PRKCA; protein kinase C, alpha (EC:2.7.11.13) hsa:5894 RAF1; v-raf-1 murine leukemia viral oncogene homolog 1 (EC:2.7.11.1)

hsa04512 ECM-receptor interaction - Homo sapiens (human) (16)

hsa:948 CD36; CD36 molecule (thrombospondin receptor) hsa:960 CD44; CD44 molecule (Indian blood group) hsa:961 CD47; CD47 molecule hsa:2335 FN1; fibronectin 1 hsa:2811 GP1BA; glycoprotein Ib (platelet), alpha polypeptide hsa:3673 ITGA2; integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) hsa:3678 ITGA5; integrin, alpha 5 (fibronectin receptor, alpha polypeptide) hsa:3688 ITGB1; integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) hsa:3691 ITGB4; integrin, beta 4 hsa:284217 LAMA1; laminin, alpha 1 hsa:3912 LAMB1; laminin, beta 1 hsa:3915 LAMC1; laminin, gamma 1 (formerly LAMB2) hsa:6385 SDC4; syndecan 4 hsa:7057 THBS1; thrombospondin 1 hsa:7448 VTN; vitronectin hsa:7450 VWF; von Willebrand factor

hsa05320 Autoimmune thyroid disease - Homo sapiens (human) (16)

hsa:1493 CTLA4; cytotoxic T-lymphocyte-associated protein 4 hsa:355 FAS; Fas cell surface death receptor hsa:3106 HLA-B; major histocompatibility complex, class I, B hsa:3108 HLA-DMA; major histocompatibility complex, class II, DM alpha hsa:3117 HLA-DQA1; major histocompatibility complex, class II, DQ alpha 1 hsa:3119 HLA-DQB1; major histocompatibility complex, class II, DQ beta 1 hsa:3122 HLA-DRA; major histocompatibility complex, class II, DR alpha hsa:3125 HLA-DRB3; major histocompatibility complex, class II, DR beta 3 hsa:3127 HLA-DRB5; major histocompatibility complex, class II, DR beta 5 hsa:3134 HLA-F; major histocompatibility complex, class I, F hsa:3439 IFNA1; interferon, alpha 1 hsa:3445 IFNA8; interferon, alpha 8 hsa:3586 IL10; interleukin 10 hsa:3558 IL2; interleukin 2 hsa:3565 IL4; interleukin 4 hsa:7173 TPO; thyroid peroxidase (EC:1.11.1.8)

hsa04672 Intestinal immune network for IgA production - Homo sapiens (human) (16)

hsa:7852 CXCR4; chemokine (C-X-C motif) receptor 4 hsa:3108 HLA-DMA; major histocompatibility complex, class II, DM alpha hsa:3117 HLA-DQA1; major histocompatibility complex, class II, DQ alpha 1 hsa:3119 HLA-DQB1; major histocompatibility complex, class II, DQ beta 1 hsa:3122 HLA-DRA; major histocompatibility complex, class II, DR alpha hsa:3125 HLA-DRB3; major histocompatibility complex, class II, DR beta 3 hsa:3127 HLA-DRB5; major histocompatibility complex, class II, DR beta 5 hsa:3586 IL10; interleukin 10 hsa:3558 IL2; interleukin 2 hsa:3565 IL4; interleukin 4 hsa:3569 IL6; interleukin 6 (interferon, beta 2) hsa:8174 MADCAM1; mucosal vascular addressin cell adhesion molecule 1 hsa:9020 MAP3K14; mitogen-activated protein kinase kinase kinase 14 (EC:2.7.11.25) hsa:7040 TGFB1; transforming growth factor, beta 1 hsa:8741 TNFSF13; tumor necrosis factor (ligand) superfamily, member 13 hsa:10673 TNFSF13B; tumor necrosis factor (ligand) superfamily, member 13b

hsa05330 Allograft rejection - Homo sapiens (human) (15)

cpd:C00533 Nitric oxide hsa:355 FAS; Fas cell surface death receptor hsa:3106 HLA-B; major histocompatibility complex, class I, B hsa:3108 HLA-DMA; major histocompatibility complex, class II, DM alpha hsa:3117 HLA-DQA1; major histocompatibility complex, class II, DQ alpha 1 hsa:3119 HLA-DQB1; major histocompatibility complex, class II, DQ beta 1 hsa:3122 HLA-DRA; major histocompatibility complex, class II, DR alpha hsa:3125 HLA-DRB3; major histocompatibility complex, class II, DR beta 3 hsa:3127 HLA-DRB5; major histocompatibility complex, class II, DR beta 5 hsa:3134 HLA-F; major histocompatibility complex, class I, F hsa:3458 IFNG; interferon, gamma hsa:3586 IL10; interleukin 10 hsa:3558 IL2; interleukin 2 hsa:3565 IL4; interleukin 4 hsa:7124 TNF; tumor necrosis factor

hsa04913 Ovarian steroidogenesis - Homo sapiens (human) (15)

cpd:C00187 Cholesterol cpd:C00280 Androstenedione cpd:C00468 Estrone cpd:C00951 Estradiol-17beta cpd:C01176 17alpha-Hydroxyprogesterone cpd:C01227 Dehydroepiandrosterone cpd:C01953 Pregnenolone hsa:10965 ACOT2; acyl-CoA thioesterase 2 (EC:3.1.2.2) hsa:115 ADCY9; adenylate cyclase 9 (EC:4.6.1.1) hsa:240 ALOX5; arachidonate 5-lipoxygenase (EC:1.13.11.34) hsa:1573 CYP2J2; cytochrome P450, family 2, subfamily J, polypeptide 2 (EC:1.14.14.1) hsa:2778 GNAS; GNAS complex locus hsa:3479 IGF1; insulin-like growth factor 1 (somatomedin C) hsa:3949 LDLR; low density lipoprotein receptor hsa:5743 PTGS2; prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1)

hsa05217 Basal cell carcinoma - Homo sapiens (human) (15)

cpd:C00187 Cholesterol hsa:324 APC; adenomatous polyposis coli hsa:650 BMP2; bone morphogenetic protein 2 hsa:652 BMP4; bone morphogenetic protein 4 hsa:1499 CTNNB1; catenin (cadherin-associated protein), beta 1, 88kDa hsa:1856 DVL2; dishevelled segment polarity protein 2 hsa:1857 DVL3; dishevelled segment polarity protein 3 hsa:2735 GLI1; GLI family zinc finger 1 hsa:2736 GLI2; GLI family zinc finger 2 hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26) hsa:51176 LEF1; lymphoid enhancer-binding factor 1 hsa:6469 SHH; sonic hedgehog hsa:6608 SMO; smoothened, frizzled family receptor hsa:7157 TP53; tumor protein p53 hsa:7472 WNT2; wingless-type MMTV integration site family member 2

hsa05310 Asthma - Homo sapiens (human) (15) Weak evidence for an inverse association between asthma and H. pylori infection in children and adults Wang et al, 2013.

cpd:C00388 Histamine cpd:C02166 Leukotriene C4 cpd:C04598 2-Acetyl-1-alkyl-sn-glycero-3-phosphocholine hsa:8288 EPX; eosinophil peroxidase (EC:1.11.1.7) hsa:3108 HLA-DMA; major histocompatibility complex, class II, DM alpha hsa:3117 HLA-DQA1; major histocompatibility complex, class II, DQ alpha 1 hsa:3119 HLA-DQB1; major histocompatibility complex, class II, DQ beta 1 hsa:3122 HLA-DRA; major histocompatibility complex, class II, DR alpha hsa:3125 HLA-DRB3; major histocompatibility complex, class II, DR beta 3 hsa:3127 HLA-DRB5; major histocompatibility complex, class II, DR beta 5 hsa:3586 IL10; interleukin 10 hsa:3596 IL13; interleukin 13 hsa:3562 IL3; interleukin 3 (colony-stimulating factor, multiple) hsa:3565 IL4; interleukin 4 hsa:7124 TNF; tumor necrosis factor

hsa04914 Progesterone-mediated oocyte maturation - Homo sapiens (human) (14)

hsa:115 ADCY9; adenylate cyclase 9 (EC:4.6.1.1) hsa:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) hsa:673 BRAF; v-raf murine sarcoma viral oncogene homolog B (EC:2.7.11.1) hsa:3320 HSP90AA1; heat shock protein 90kDa alpha (cytosolic), class A member 1 hsa:3326 HSP90AB1; heat shock protein 90kDa alpha (cytosolic), class B member 1 hsa:3479 IGF1; insulin-like growth factor 1 (somatomedin C) hsa:3845 KRAS; Kirsten rat sarcoma viral oncogene homolog hsa:5604 MAP2K1; mitogen-activated protein kinase kinase 1 (EC:2.7.12.2) hsa:5594 MAPK1; mitogen-activated protein kinase 1 (EC:2.7.11.24) hsa:1432 MAPK14; mitogen-activated protein kinase 14 (EC:2.7.11.24) hsa:5595 MAPK3; mitogen-activated protein kinase 3 (EC:2.7.11.24) hsa:5599 MAPK8; mitogen-activated protein kinase 8 (EC:2.7.11.24) hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha) hsa:5894 RAF1; v-raf-1 murine leukemia viral oncogene homolog 1 (EC:2.7.11.1)

hsa00480 Glutathione metabolism - Homo sapiens (human) (14)

cpd:C00005 NADPH cpd:C00006 NADP+ cpd:C00025 L-Glutamate cpd:C00051 Glutathione cpd:C00072 Ascorbate cpd:C00077 L-Ornithine cpd:C00315 Spermidine cpd:C00750 Spermine hsa:2678 GGT1; gamma-glutamyltransferase 1 (EC:2.3.2.2 3.4.19.13 3.4.19.14) hsa:2947 GSTM3; glutathione S-transferase mu 3 (brain) (EC:2.5.1.18) hsa:2948 GSTM4; glutathione S-transferase mu 4 (EC:2.5.1.18) hsa:2950 GSTP1; glutathione S-transferase pi 1 (EC:2.5.1.18) hsa:4953 ODC1; ornithine decarboxylase 1 (EC:4.1.1.17) hsa:6611 SMS; spermine synthase (EC:2.5.1.22)

hsa04150 mTOR signaling pathway - Homo sapiens (human) (13)

hsa:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) hsa:673 BRAF; v-raf murine sarcoma viral oncogene homolog B (EC:2.7.11.1) hsa:3091 HIF1A; hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) hsa:3479 IGF1; insulin-like growth factor 1 (somatomedin C) hsa:3551 IKBKB; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta (EC:2.7.11.10) hsa:3667 IRS1; insulin receptor substrate 1 hsa:5594 MAPK1; mitogen-activated protein kinase 1 (EC:2.7.11.24) hsa:5595 MAPK3; mitogen-activated protein kinase 3 (EC:2.7.11.24) hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha) hsa:5578 PRKCA; protein kinase C, alpha (EC:2.7.11.13) hsa:5728 PTEN; phosphatase and tensin homolog (EC:3.1.3.67 3.1.3.16 3.1.3.48) hsa:7124 TNF; tumor necrosis factor hsa:7422 VEGFA; vascular endothelial growth factor A

hsa04120 Ubiquitin mediated proteolysis - Homo sapiens (human) (13)

hsa:329 BIRC2; baculoviral IAP repeat containing 2 hsa:330 BIRC3; baculoviral IAP repeat containing 3 hsa:672 BRCA1; breast cancer 1, early onset hsa:26091 HERC4; HECT and RLD domain containing E3 ubiquitin protein ligase 4 hsa:4214 MAP3K1; mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase (EC:2.7.11.25) hsa:4193 MDM2; MDM2 oncogene, E3 ubiquitin protein ligase hsa:6502 SKP2; S-phase kinase-associated protein 2, E3 ubiquitin protein ligase hsa:6923 TCEB2; transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B) hsa:7189 TRAF6; TNF receptor-associated factor 6, E3 ubiquitin protein ligase hsa:7317 UBA1; ubiquitin-like modifier activating enzyme 1 (EC:6.3.2.19) hsa:11065 UBE2C; ubiquitin-conjugating enzyme E2C (EC:6.3.2.19) hsa:7328 UBE2H; ubiquitin-conjugating enzyme E2H (EC:6.3.2.19) hsa:7334 UBE2N; ubiquitin-conjugating enzyme E2N (EC:6.3.2.19)

hsa04070 Phosphatidylinositol signaling system - Homo sapiens (human) (13)

hsa:10423 CDIPT; CDP-diacylglycerol--inositol 3-phosphatidyltransferase (EC:2.7.8.11) hsa:3636 INPPL1; inositol polyphosphate phosphatase-like 1 (EC:3.1.3.86) hsa:3709 ITPR2; inositol 1,4,5-trisphosphate receptor, type 2 hsa:5287 PIK3C2B; phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta (EC:2.7.1.154) hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha) hsa:200576 PIKFYVE; phosphoinositide kinase, FYVE finger containing (EC:2.7.1.150) hsa:8395 PIP5K1B; phosphatidylinositol-4-phosphate 5-kinase, type I, beta (EC:2.7.1.68) hsa:5330 PLCB2; phospholipase C, beta 2 (EC:3.1.4.11) hsa:5332 PLCB4; phospholipase C, beta 4 (EC:3.1.4.11) hsa:51196 PLCE1; phospholipase C, epsilon 1 (EC:3.1.4.11) hsa:5335 PLCG1; phospholipase C, gamma 1 (EC:3.1.4.11) hsa:5578 PRKCA; protein kinase C, alpha (EC:2.7.11.13) hsa:5728 PTEN; phosphatase and tensin homolog (EC:3.1.3.67 3.1.3.16 3.1.3.48)

hsa00010 Glycolysis / Gluconeogenesis - Homo sapiens (human) (13)

cpd:C00033 Acetate cpd:C00084 Acetaldehyde hsa:131 ADH7; alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide (EC:1.1.1.1) hsa:226 ALDOA; aldolase A, fructose-bisphosphate (EC:4.1.2.13) hsa:230 ALDOC; aldolase C, fructose-bisphosphate (EC:4.1.2.13) hsa:1738 DLD; dihydrolipoamide dehydrogenase (EC:1.8.1.4) hsa:2023 ENO1; enolase 1, (alpha) (EC:4.2.1.11) hsa:2027 ENO3; enolase 3 (beta, muscle) (EC:4.2.1.11) hsa:2821 GPI; glucose-6-phosphate isomerase (EC:5.3.1.9) hsa:3945 LDHB; lactate dehydrogenase B (EC:1.1.1.27) hsa:5106 PCK2; phosphoenolpyruvate carboxykinase 2 (mitochondrial) (EC:4.1.1.32) hsa:55276 PGM2; phosphoglucomutase 2 (EC:5.4.2.2 5.4.2.7) hsa:7167 TPI1; triosephosphate isomerase 1 (EC:5.3.1.1)

hsa05216 Thyroid cancer - Homo sapiens (human) (13)

hsa:673 BRAF; v-raf murine sarcoma viral oncogene homolog B (EC:2.7.11.1) hsa:595 CCND1; cyclin D1 hsa:999 CDH1; cadherin 1, type 1, E-cadherin (epithelial) hsa:1499 CTNNB1; catenin (cadherin-associated protein), beta 1, 88kDa hsa:3845 KRAS; Kirsten rat sarcoma viral oncogene homolog hsa:51176 LEF1; lymphoid enhancer-binding factor 1 hsa:5604 MAP2K1; mitogen-activated protein kinase kinase 1 (EC:2.7.12.2) hsa:5594 MAPK1; mitogen-activated protein kinase 1 (EC:2.7.11.24) hsa:5595 MAPK3; mitogen-activated protein kinase 3 (EC:2.7.11.24) hsa:4609 MYC; v-myc avian myelocytomatosis viral oncogene homolog hsa:4893 NRAS; neuroblastoma RAS viral (v-ras) oncogene homolog hsa:5468 PPARG; peroxisome proliferator-activated receptor gamma hsa:7157 TP53; tumor protein p53

hsa04723 Retrograde endocannabinoid signaling - Homo sapiens (human) (12)

cpd:C00025 L-Glutamate hsa:115 ADCY9; adenylate cyclase 9 (EC:4.6.1.1) hsa:2783 GNB2; guanine nucleotide binding protein (G protein), beta polypeptide 2 hsa:3709 ITPR2; inositol 1,4,5-trisphosphate receptor, type 2 hsa:5594 MAPK1; mitogen-activated protein kinase 1 (EC:2.7.11.24) hsa:1432 MAPK14; mitogen-activated protein kinase 14 (EC:2.7.11.24) hsa:5595 MAPK3; mitogen-activated protein kinase 3 (EC:2.7.11.24) hsa:5599 MAPK8; mitogen-activated protein kinase 8 (EC:2.7.11.24) hsa:5330 PLCB2; phospholipase C, beta 2 (EC:3.1.4.11) hsa:5332 PLCB4; phospholipase C, beta 4 (EC:3.1.4.11) hsa:5578 PRKCA; protein kinase C, alpha (EC:2.7.11.13) hsa:5743 PTGS2; prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1)

hsa03320 PPAR signaling pathway - Homo sapiens (human) (12) Helicobacter + PPAR Pubmed

cpd:C02165 Leukotriene B4 hsa:8309 ACOX2; acyl-CoA oxidase 2, branched chain (EC:1.17.99.3) hsa:335 APOA1; apolipoprotein A-I hsa:336 APOA2; apolipoprotein A-II hsa:948 CD36; CD36 molecule (thrombospondin receptor) hsa:3611 ILK; integrin-linked kinase (EC:2.7.11.1) hsa:4312 MMP1; matrix metallopeptidase 1 (interstitial collagenase) (EC:3.4.24.7) hsa:5106 PCK2; phosphoenolpyruvate carboxykinase 2 (mitochondrial) (EC:4.1.1.32) hsa:5360 PLTP; phospholipid transfer protein hsa:5467 PPARD; peroxisome proliferator-activated receptor delta hsa:5468 PPARG; peroxisome proliferator-activated receptor gamma hsa:10580 SORBS1; sorbin and SH3 domain containing 1

hsa05410 Hypertrophic cardiomyopathy (HCM) - Homo sapiens (human) (12)

hsa:1636 ACE; angiotensin I converting enzyme (EC:3.4.15.1) hsa:70 ACTC1; actin, alpha, cardiac muscle 1 hsa:3479 IGF1; insulin-like growth factor 1 (somatomedin C) hsa:3569 IL6; interleukin 6 (interferon, beta 2) hsa:3673 ITGA2; integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) hsa:3678 ITGA5; integrin, alpha 5 (fibronectin receptor, alpha polypeptide) hsa:3688 ITGB1; integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) hsa:3691 ITGB4; integrin, beta 4 hsa:7040 TGFB1; transforming growth factor, beta 1 hsa:7042 TGFB2; transforming growth factor, beta 2 hsa:7124 TNF; tumor necrosis factor hsa:7169 TPM2; tropomyosin 2 (beta)

hsa05414 Dilated cardiomyopathy - Homo sapiens (human) (12)

hsa:70 ACTC1; actin, alpha, cardiac muscle 1 hsa:115 ADCY9; adenylate cyclase 9 (EC:4.6.1.1) hsa:2778 GNAS; GNAS complex locus hsa:3479 IGF1; insulin-like growth factor 1 (somatomedin C) hsa:3673 ITGA2; integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) hsa:3678 ITGA5; integrin, alpha 5 (fibronectin receptor, alpha polypeptide) hsa:3688 ITGB1; integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) hsa:3691 ITGB4; integrin, beta 4 hsa:7040 TGFB1; transforming growth factor, beta 1 hsa:7042 TGFB2; transforming growth factor, beta 2 hsa:7124 TNF; tumor necrosis factor hsa:7169 TPM2; tropomyosin 2 (beta)

hsa04142 Lysosome - Homo sapiens (human) (11)

hsa:175 AGA; aspartylglucosaminidase (EC:3.5.1.26) hsa:164 AP1G1; adaptor-related protein complex 1, gamma 1 subunit hsa:533 ATP6V0B; ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b (EC:3.6.3.14) hsa:968 CD68; CD68 molecule hsa:1509 CTSD; cathepsin D (EC:3.4.23.5) hsa:1522 CTSZ; cathepsin Z (EC:3.4.18.1) hsa:3074 HEXB; hexosaminidase B (beta polypeptide) (EC:3.2.1.52) hsa:3423 IDS; iduronate 2-sulfatase (EC:3.1.6.13) hsa:3916 LAMP1; lysosomal-associated membrane protein 1 hsa:3920 LAMP2; lysosomal-associated membrane protein 2 hsa:10312 TCIRG1; T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3 (EC:3.6.3.6)

hsa02010 ABC transporters - Homo sapiens (human) (11)

cpd:C00025 L-Glutamate cpd:C00051 Glutathione cpd:C00062 L-Arginine cpd:C00064 L-Glutamine cpd:C00077 L-Ornithine cpd:C00086 Urea cpd:C00315 Spermidine cpd:C00338 Lipopolysaccharide cpd:C06767 Hemine hsa:5243 ABCB1; ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) hsa:1080 CFTR; cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) (EC:3.6.3.49)

hsa00562 Inositol phosphate metabolism - Homo sapiens (human) (11)

hsa:10423 CDIPT; CDP-diacylglycerol--inositol 3-phosphatidyltransferase (EC:2.7.8.11) hsa:3636 INPPL1; inositol polyphosphate phosphatase-like 1 (EC:3.1.3.86) hsa:5287 PIK3C2B; phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta (EC:2.7.1.154) hsa:200576 PIKFYVE; phosphoinositide kinase, FYVE finger containing (EC:2.7.1.150) hsa:8395 PIP5K1B; phosphatidylinositol-4-phosphate 5-kinase, type I, beta (EC:2.7.1.68) hsa:5330 PLCB2; phospholipase C, beta 2 (EC:3.1.4.11) hsa:5332 PLCB4; phospholipase C, beta 4 (EC:3.1.4.11) hsa:51196 PLCE1; phospholipase C, epsilon 1 (EC:3.1.4.11) hsa:5335 PLCG1; phospholipase C, gamma 1 (EC:3.1.4.11) hsa:5728 PTEN; phosphatase and tensin homolog (EC:3.1.3.67 3.1.3.16 3.1.3.48) hsa:7167 TPI1; triosephosphate isomerase 1 (EC:5.3.1.1)

hsa00230 Purine metabolism - Homo sapiens (human) (11) Helicobacter and purine Pubmed

cpd:C00011 CO2 cpd:C00014 Ammonia cpd:C00064 L-Glutamine cpd:C00086 Urea hsa:115 ADCY9; adenylate cyclase 9 (EC:4.6.1.1) hsa:1716 DGUOK; deoxyguanosine kinase (EC:2.7.1.113) hsa:3615 IMPDH2; IMP (inosine 5'-monophosphate) dehydrogenase 2 (EC:1.1.1.205) hsa:5138 PDE2A; phosphodiesterase 2A, cGMP-stimulated (EC:3.1.4.17) hsa:55276 PGM2; phosphoglucomutase 2 (EC:5.4.2.2 5.4.2.7) hsa:4860 PNP; purine nucleoside phosphorylase (EC:2.4.2.1) hsa:10621 POLR3F; polymerase (RNA) III (DNA directed) polypeptide F, 39 kDa

hsa04340 Hedgehog signaling pathway - Homo sapiens (human) (10)

cpd:C00187 Cholesterol hsa:650 BMP2; bone morphogenetic protein 2 hsa:652 BMP4; bone morphogenetic protein 4 hsa:2735 GLI1; GLI family zinc finger 1 hsa:2736 GLI2; GLI family zinc finger 2 hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26) hsa:3549 IHH; indian hedgehog hsa:6469 SHH; sonic hedgehog hsa:6608 SMO; smoothened, frizzled family receptor hsa:7472 WNT2; wingless-type MMTV integration site family member 2

hsa04966 Collecting duct acid secretion - Homo sapiens (human) (10)

cpd:C00011 CO2 cpd:C00014 Ammonia cpd:C00080 H+ cpd:C00698 Cl- hsa:495 ATP4A; ATPase, H+/K+ exchanging, alpha polypeptide (EC:3.6.3.10) hsa:525 ATP6V1B1; ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1 (EC:3.6.3.14) hsa:9296 ATP6V1F; ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F (EC:3.6.3.14) hsa:9550 ATP6V1G1; ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1 (EC:3.6.3.14) hsa:760 CA2; carbonic anhydrase II (EC:4.2.1.1) hsa:10312 TCIRG1; T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3 (EC:3.6.3.6)

hsa00982 Drug metabolism - cytochrome P450 - Homo sapiens (human) (10)

hsa:131 ADH7; alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide (EC:1.1.1.1) hsa:1544 CYP1A2; cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) hsa:1555 CYP2B6; cytochrome P450, family 2, subfamily B, polypeptide 6 (EC:1.14.14.1) hsa:1557 CYP2C19; cytochrome P450, family 2, subfamily C, polypeptide 19 (EC:1.14.13.48 1.14.13.49 1.14.13.80) hsa:1565 CYP2D6; cytochrome P450, family 2, subfamily D, polypeptide 6 (EC:1.14.14.1) hsa:2947 GSTM3; glutathione S-transferase mu 3 (brain) (EC:2.5.1.18) hsa:2948 GSTM4; glutathione S-transferase mu 4 (EC:2.5.1.18) hsa:2950 GSTP1; glutathione S-transferase pi 1 (EC:2.5.1.18) hsa:4128 MAOA; monoamine oxidase A (EC:1.4.3.4) hsa:54658 UGT1A1; UDP glucuronosyltransferase 1 family, polypeptide A1 (EC:2.4.1.17)

hsa04320 Dorso-ventral axis formation - Homo sapiens (human) (10)

hsa:1956 EGFR; epidermal growth factor receptor (EC:2.7.10.1) hsa:2114 ETS2; v-ets avian erythroblastosis virus E26 oncogene homolog 2 hsa:2120 ETV6; ets variant 6 hsa:2885 GRB2; growth factor receptor-bound protein 2 hsa:3845 KRAS; Kirsten rat sarcoma viral oncogene homolog hsa:5604 MAP2K1; mitogen-activated protein kinase kinase 1 (EC:2.7.12.2) hsa:5594 MAPK1; mitogen-activated protein kinase 1 (EC:2.7.11.24) hsa:5595 MAPK3; mitogen-activated protein kinase 3 (EC:2.7.11.24) hsa:4853 NOTCH2; notch 2 hsa:6654 SOS1; son of sevenless homolog 1 (Drosophila)

hsa00590 Arachidonic acid metabolism - Homo sapiens (human) (10)

cpd:C00584 Prostaglandin E2 cpd:C02165 Leukotriene B4 cpd:C02166 Leukotriene C4 ec:3.1.1.32 phospholipase A1 hsa:240 ALOX5; arachidonate 5-lipoxygenase (EC:1.13.11.34) hsa:1555 CYP2B6; cytochrome P450, family 2, subfamily B, polypeptide 6 (EC:1.14.14.1) hsa:1557 CYP2C19; cytochrome P450, family 2, subfamily C, polypeptide 19 (EC:1.14.13.48 1.14.13.49 1.14.13.80) hsa:1573 CYP2J2; cytochrome P450, family 2, subfamily J, polypeptide 2 (EC:1.14.14.1) hsa:2678 GGT1; gamma-glutamyltransferase 1 (EC:2.3.2.2 3.4.19.13 3.4.19.14) hsa:5743 PTGS2; prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1)

hsa00564 Glycerophospholipid metabolism - Homo sapiens (human) (10)

cpd:C00084 Acetaldehyde cpd:C02737 Phosphatidylserine cpd:C04233 2-Acyl-sn-glycero-3-phosphocholine cpd:C05973 2-Acyl-sn-glycero-3-phosphoethanolamine ec:3.1.1.32 phospholipase A1 hsa:10423 CDIPT; CDP-diacylglycerol--inositol 3-phosphatidyltransferase (EC:2.7.8.11) hsa:1119 CHKA; choline kinase alpha (EC:2.7.1.32 2.7.1.82) hsa:9468 PCYT1B; phosphate cytidylyltransferase 1, choline, beta (EC:2.7.7.15) hsa:5337 PLD1; phospholipase D1, phosphatidylcholine-specific (EC:3.1.4.4) hsa:8613 PPAP2B; phosphatidic acid phosphatase type 2B (EC:3.1.3.4)

hsa04960 Aldosterone-regulated sodium reabsorption - Homo sapiens (human) (10)

cpd:C00698 Cl- hsa:3479 IGF1; insulin-like growth factor 1 (somatomedin C) hsa:3667 IRS1; insulin receptor substrate 1 hsa:3758 KCNJ1; potassium inwardly-rectifying channel, subfamily J, member 1 hsa:3845 KRAS; Kirsten rat sarcoma viral oncogene homolog hsa:5594 MAPK1; mitogen-activated protein kinase 1 (EC:2.7.11.24) hsa:5595 MAPK3; mitogen-activated protein kinase 3 (EC:2.7.11.24) hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha) hsa:5578 PRKCA; protein kinase C, alpha (EC:2.7.11.13) hsa:9351 SLC9A3R2; solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2

hsa05340 Primary immunodeficiency - Homo sapiens (human) (10)

hsa:29760 BLNK; B-cell linker hsa:695 BTK; Bruton agammaglobulinemia tyrosine kinase (EC:2.7.10.2) hsa:915 CD3D; CD3d molecule, delta (CD3-TCR complex) hsa:4261 CIITA; class II, major histocompatibility complex, transactivator hsa:8517 IKBKG; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma hsa:3561 IL2RG; interleukin 2 receptor, gamma hsa:3575 IL7R; interleukin 7 receptor hsa:3718 JAK3; Janus kinase 3 (EC:2.7.10.2) hsa:3932 LCK; lymphocyte-specific protein tyrosine kinase (EC:2.7.10.2) hsa:5788 PTPRC; protein tyrosine phosphatase, receptor type, C (EC:3.1.3.48)

hsa05204 Chemical carcinogenesis - Homo sapiens (human) (10)

cpd:C00027 Hydrogen peroxide hsa:131 ADH7; alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide (EC:1.1.1.1) hsa:1544 CYP1A2; cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) hsa:1555 CYP2B6; cytochrome P450, family 2, subfamily B, polypeptide 6 (EC:1.14.14.1) hsa:1557 CYP2C19; cytochrome P450, family 2, subfamily C, polypeptide 19 (EC:1.14.13.48 1.14.13.49 1.14.13.80) hsa:2947 GSTM3; glutathione S-transferase mu 3 (brain) (EC:2.5.1.18) hsa:2948 GSTM4; glutathione S-transferase mu 4 (EC:2.5.1.18) hsa:2950 GSTP1; glutathione S-transferase pi 1 (EC:2.5.1.18) hsa:5743 PTGS2; prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) hsa:54658 UGT1A1; UDP glucuronosyltransferase 1 family, polypeptide A1 (EC:2.4.1.17)

hsa04930 Type II diabetes mellitus - Homo sapiens (human) (10)

hsa:3551 IKBKB; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta (EC:2.7.11.10) hsa:3667 IRS1; insulin receptor substrate 1 hsa:5594 MAPK1; mitogen-activated protein kinase 1 (EC:2.7.11.24) hsa:5595 MAPK3; mitogen-activated protein kinase 3 (EC:2.7.11.24) hsa:5599 MAPK8; mitogen-activated protein kinase 8 (EC:2.7.11.24) hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha) hsa:5580 PRKCD; protein kinase C, delta (EC:2.7.10.2 2.7.11.13) hsa:5590 PRKCZ; protein kinase C, zeta (EC:2.7.11.13) hsa:8835 SOCS2; suppressor of cytokine signaling 2 hsa:7124 TNF; tumor necrosis factor

hsa04964 Proximal tubule bicarbonate reclamation - Homo sapiens (human) (9)

cpd:C00011 CO2 cpd:C00014 Ammonia cpd:C00025 L-Glutamate cpd:C00064 L-Glutamine cpd:C00080 H+ cpd:C00698 Cl- hsa:760 CA2; carbonic anhydrase II (EC:4.2.1.1) hsa:5106 PCK2; phosphoenolpyruvate carboxykinase 2 (mitochondrial) (EC:4.1.1.32) hsa:8671 SLC4A4; solute carrier family 4 (sodium bicarbonate cotransporter), member 4

hsa00260 Glycine, serine and threonine metabolism - Homo sapiens (human) (9)

cpd:C00011 CO2 cpd:C00014 Ammonia cpd:C00078 L-Tryptophan cpd:C02737 Phosphatidylserine hsa:1738 DLD; dihydrolipoamide dehydrogenase (EC:1.8.1.4) hsa:2628 GATM; glycine amidinotransferase (L-arginine:glycine amidinotransferase) (EC:2.1.4.1) hsa:4128 MAOA; monoamine oxidase A (EC:1.4.3.4) hsa:29968 PSAT1; phosphoserine aminotransferase 1 (EC:2.6.1.52) hsa:5723 PSPH; phosphoserine phosphatase (EC:3.1.3.3)

hsa04727 GABAergic synapse - Homo sapiens (human) (9)

cpd:C00025 L-Glutamate cpd:C00064 L-Glutamine cpd:C00698 Cl- hsa:115 ADCY9; adenylate cyclase 9 (EC:4.6.1.1) hsa:23710 GABARAPL1; GABA(A) receptor-associated protein like 1 hsa:2783 GNB2; guanine nucleotide binding protein (G protein), beta polypeptide 2 hsa:5578 PRKCA; protein kinase C, alpha (EC:2.7.11.13) hsa:54407 SLC38A2; solute carrier family 38, member 2 hsa:6714 SRC; v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (EC:2.7.10.2)

hsa04721 Synaptic vesicle cycle - Homo sapiens (human) (9)

cpd:C00025 L-Glutamate cpd:C00080 H+ cpd:C00388 Histamine cpd:C03758 Dopamine hsa:533 ATP6V0B; ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b (EC:3.6.3.14) hsa:525 ATP6V1B1; ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1 (EC:3.6.3.14) hsa:9296 ATP6V1F; ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F (EC:3.6.3.14) hsa:9550 ATP6V1G1; ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1 (EC:3.6.3.14) hsa:10312 TCIRG1; T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3 (EC:3.6.3.6)

hsa04114 Oocyte meiosis - Homo sapiens (human) (9)

hsa:115 ADCY9; adenylate cyclase 9 (EC:4.6.1.1) hsa:3479 IGF1; insulin-like growth factor 1 (somatomedin C) hsa:3709 ITPR2; inositol 1,4,5-trisphosphate receptor, type 2 hsa:5604 MAP2K1; mitogen-activated protein kinase kinase 1 (EC:2.7.12.2) hsa:5594 MAPK1; mitogen-activated protein kinase 1 (EC:2.7.11.24) hsa:5595 MAPK3; mitogen-activated protein kinase 3 (EC:2.7.11.24) hsa:5530 PPP3CA; protein phosphatase 3, catalytic subunit, alpha isozyme (EC:3.1.3.16) hsa:7529 YWHAB; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide hsa:10971 YWHAQ; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide

hsa00140 Steroid hormone biosynthesis - Homo sapiens (human) (9)

cpd:C00187 Cholesterol cpd:C00280 Androstenedione cpd:C00468 Estrone cpd:C00951 Estradiol-17beta cpd:C01176 17alpha-Hydroxyprogesterone cpd:C01227 Dehydroepiandrosterone cpd:C01953 Pregnenolone hsa:1312 COMT; catechol-O-methyltransferase (EC:2.1.1.6) hsa:54658 UGT1A1; UDP glucuronosyltransferase 1 family, polypeptide A1 (EC:2.4.1.17)

hsa05033 Nicotine addiction - Homo sapiens (human) (9)

cpd:C00025 L-Glutamate cpd:C00698 Cl- hsa:2902 GRIN1; glutamate receptor, ionotropic, N-methyl D-aspartate 1 hsa:2903 GRIN2A; glutamate receptor, ionotropic, N-methyl D-aspartate 2A hsa:2904 GRIN2B; glutamate receptor, ionotropic, N-methyl D-aspartate 2B hsa:2905 GRIN2C; glutamate receptor, ionotropic, N-methyl D-aspartate 2C hsa:2906 GRIN2D; glutamate receptor, ionotropic, N-methyl D-aspartate 2D hsa:116443 GRIN3A; glutamate receptor, ionotropic, N-methyl-D-aspartate 3A hsa:116444 GRIN3B; glutamate receptor, ionotropic, N-methyl-D-aspartate 3B

hsa04911 Insulin secretion - Homo sapiens (human) (9)

hsa:115 ADCY9; adenylate cyclase 9 (EC:4.6.1.1) hsa:1386 ATF2; activating transcription factor 2 hsa:886 CCKAR; cholecystokinin A receptor hsa:1385 CREB1; cAMP responsive element binding protein 1 hsa:9586 CREB5; cAMP responsive element binding protein 5 hsa:2778 GNAS; GNAS complex locus hsa:5330 PLCB2; phospholipase C, beta 2 (EC:3.1.4.11) hsa:5332 PLCB4; phospholipase C, beta 4 (EC:3.1.4.11) hsa:5578 PRKCA; protein kinase C, alpha (EC:2.7.11.13)

hsa03040 Spliceosome - Homo sapiens (human) (9)

hsa:22985 ACIN1; apoptotic chromatin condensation inducer 1 hsa:3178 HNRNPA1; heterogeneous nuclear ribonucleoprotein A1 hsa:3190 HNRNPK; heterogeneous nuclear ribonucleoprotein K hsa:3192 HNRNPU; heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) hsa:3312 HSPA8; heat shock 70kDa protein 8 hsa:25804 LSM4; LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae) hsa:6632 SNRPD1; small nuclear ribonucleoprotein D1 polypeptide 16kDa hsa:6637 SNRPG; small nuclear ribonucleoprotein polypeptide G hsa:51729 WBP11; WW domain binding protein 11

hsa00980 Metabolism of xenobiotics by cytochrome P450 - Homo sapiens (human) (9)

hsa:131 ADH7; alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide (EC:1.1.1.1) hsa:1544 CYP1A2; cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) hsa:1555 CYP2B6; cytochrome P450, family 2, subfamily B, polypeptide 6 (EC:1.14.14.1) hsa:1557 CYP2C19; cytochrome P450, family 2, subfamily C, polypeptide 19 (EC:1.14.13.48 1.14.13.49 1.14.13.80) hsa:1565 CYP2D6; cytochrome P450, family 2, subfamily D, polypeptide 6 (EC:1.14.14.1) hsa:2947 GSTM3; glutathione S-transferase mu 3 (brain) (EC:2.5.1.18) hsa:2948 GSTM4; glutathione S-transferase mu 4 (EC:2.5.1.18) hsa:2950 GSTP1; glutathione S-transferase pi 1 (EC:2.5.1.18) hsa:54658 UGT1A1; UDP glucuronosyltransferase 1 family, polypeptide A1 (EC:2.4.1.17)

hsa05032 Morphine addiction - Homo sapiens (human) (8)

cpd:C00698 Cl- cpd:C03758 Dopamine hsa:115 ADCY9; adenylate cyclase 9 (EC:4.6.1.1) hsa:408 ARRB1; arrestin, beta 1 hsa:2778 GNAS; GNAS complex locus hsa:2783 GNB2; guanine nucleotide binding protein (G protein), beta polypeptide 2 hsa:5138 PDE2A; phosphodiesterase 2A, cGMP-stimulated (EC:3.1.4.17) hsa:5578 PRKCA; protein kinase C, alpha (EC:2.7.11.13)

hsa00350 Tyrosine metabolism - Homo sapiens (human) (8)

cpd:C00082 L-Tyrosine cpd:C00355 3,4-Dihydroxy-L-phenylalanine cpd:C03758 Dopamine hsa:131 ADH7; alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide (EC:1.1.1.1) hsa:1312 COMT; catechol-O-methyltransferase (EC:2.1.1.6) hsa:1644 DDC; dopa decarboxylase (aromatic L-amino acid decarboxylase) (EC:4.1.1.28) hsa:4128 MAOA; monoamine oxidase A (EC:1.4.3.4) hsa:7173 TPO; thyroid peroxidase (EC:1.11.1.8)

hsa00860 Porphyrin and chlorophyll metabolism - Homo sapiens (human) (8)

cpd:C00025 L-Glutamate cpd:C01079 Protoporphyrinogen IX cpd:C02823 Cyanocobalamin cpd:C05769 Coproporphyrin I hsa:210 ALAD; aminolevulinate dehydratase (EC:4.2.1.24) hsa:2512 FTL; ferritin, light polypeptide hsa:3162 HMOX1; heme oxygenase (decycling) 1 (EC:1.14.99.3) hsa:54658 UGT1A1; UDP glucuronosyltransferase 1 family, polypeptide A1 (EC:2.4.1.17)

hsa00630 Glyoxylate and dicarboxylate metabolism - Homo sapiens (human) (8)

cpd:C00007 Oxygen cpd:C00011 CO2 cpd:C00014 Ammonia cpd:C00025 L-Glutamate cpd:C00027 Hydrogen peroxide cpd:C00064 L-Glutamine hsa:847 CAT; catalase (EC:1.11.1.6) hsa:54363 HAO1; hydroxyacid oxidase (glycolate oxidase) 1 (EC:1.1.3.15)

hsa00380 Tryptophan metabolism - Homo sapiens (human) (8)

cpd:C00078 L-Tryptophan cpd:C00328 L-Kynurenine cpd:C01598 Melatonin hsa:847 CAT; catalase (EC:1.11.1.6) hsa:1544 CYP1A2; cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) hsa:1644 DDC; dopa decarboxylase (aromatic L-amino acid decarboxylase) (EC:4.1.1.28) hsa:3030 HADHA; hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit (EC:4.2.1.17 1.1.1.211) hsa:4128 MAOA; monoamine oxidase A (EC:1.4.3.4)

hsa04977 Vitamin digestion and absorption - Homo sapiens (human) (8)

cpd:C00018 Pyridoxal phosphate cpd:C00072 Ascorbate cpd:C00080 H+ cpd:C00187 Cholesterol cpd:C00473 Retinol cpd:C02094 beta-Carotene cpd:C02477 alpha-Tocopherol hsa:335 APOA1; apolipoprotein A-I

hsa00240 Pyrimidine metabolism - Homo sapiens (human) (7)

cpd:C00064 L-Glutamine cpd:C00086 Urea cpd:C00342 Thioredoxin hsa:790 CAD; carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase (EC:2.1.3.2 3.5.2.3 6.3.5.5) hsa:4860 PNP; purine nucleoside phosphorylase (EC:2.4.2.1) hsa:10621 POLR3F; polymerase (RNA) III (DNA directed) polypeptide F, 39 kDa hsa:7378 UPP1; uridine phosphorylase 1 (EC:2.4.2.3)

hsa04140 Regulation of autophagy - Homo sapiens (human) (7)

hsa:9140 ATG12; autophagy related 12 hsa:84938 ATG4C; autophagy related 4C, cysteine peptidase hsa:9474 ATG5; autophagy related 5 hsa:23710 GABARAPL1; GABA(A) receptor-associated protein like 1 hsa:3439 IFNA1; interferon, alpha 1 hsa:3445 IFNA8; interferon, alpha 8 hsa:3458 IFNG; interferon, gamma

hsa04978 Mineral absorption - Homo sapiens (human) (7)

cpd:C00064 L-Glutamine cpd:C00078 L-Tryptophan cpd:C00080 H+ cpd:C00698 Cl- hsa:2512 FTL; ferritin, light polypeptide hsa:3162 HMOX1; heme oxygenase (decycling) 1 (EC:1.14.99.3) hsa:7018 TF; transferrin

hsa00830 Retinol metabolism - Homo sapiens (human) (7)

cpd:C00473 Retinol cpd:C02094 beta-Carotene hsa:131 ADH7; alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide (EC:1.1.1.1) hsa:1544 CYP1A2; cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) hsa:1555 CYP2B6; cytochrome P450, family 2, subfamily B, polypeptide 6 (EC:1.14.14.1) hsa:1557 CYP2C19; cytochrome P450, family 2, subfamily C, polypeptide 19 (EC:1.14.13.48 1.14.13.49 1.14.13.80) hsa:54658 UGT1A1; UDP glucuronosyltransferase 1 family, polypeptide A1 (EC:2.4.1.17)

hsa04146 Peroxisome - Homo sapiens (human) (7)

hsa:8309 ACOX2; acyl-CoA oxidase 2, branched chain (EC:1.17.99.3) hsa:23600 AMACR; alpha-methylacyl-CoA racemase (EC:5.1.99.4) hsa:847 CAT; catalase (EC:1.11.1.6) hsa:54363 HAO1; hydroxyacid oxidase (glycolate oxidase) 1 (EC:1.1.3.15) hsa:4843 NOS2; nitric oxide synthase 2, inducible (EC:1.14.13.39) hsa:196743 PAOX; polyamine oxidase (exo-N4-amino) (EC:1.5.3.13) hsa:5189 PEX1; peroxisomal biogenesis factor 1

hsa00601 Glycosphingolipid biosynthesis - lacto and neolacto series - Homo sapiens (human) (7)

hsa:28 ABO; ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase) (EC:2.4.1.37 2.4.1.40) hsa:11041 B3GNT1; UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1 (EC:2.4.1.149) hsa:84002 B3GNT5; UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5 (EC:2.4.1.206) hsa:2524 FUT2; fucosyltransferase 2 (secretor status included) (EC:2.4.1.69) hsa:2525 FUT3; fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group) (EC:2.4.1.65) hsa:2526 FUT4; fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific) (EC:2.4.1.-) hsa:2529 FUT7; fucosyltransferase 7 (alpha (1,3) fucosyltransferase) (EC:2.4.1.-)

hsa00020 Citrate cycle (TCA cycle) - Homo sapiens (human) (7)

hsa:1738 DLD; dihydrolipoamide dehydrogenase (EC:1.8.1.4) hsa:2271 FH; fumarate hydratase (EC:4.2.1.2) hsa:5106 PCK2; phosphoenolpyruvate carboxykinase 2 (mitochondrial) (EC:4.1.1.32) hsa:6389 SDHA; succinate dehydrogenase complex, subunit A, flavoprotein (Fp) (EC:1.3.5.1) hsa:6390 SDHB; succinate dehydrogenase complex, subunit B, iron sulfur (Ip) (EC:1.3.5.1) hsa:6391 SDHC; succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa hsa:6392 SDHD; succinate dehydrogenase complex, subunit D, integral membrane protein

hsa03050 Proteasome - Homo sapiens (human) (7)

hsa:3458 IFNG; interferon, gamma hsa:5689 PSMB1; proteasome (prosome, macropain) subunit, beta type, 1 (EC:3.4.25.1) hsa:5699 PSMB10; proteasome (prosome, macropain) subunit, beta type, 10 (EC:3.4.25.1) hsa:5695 PSMB7; proteasome (prosome, macropain) subunit, beta type, 7 (EC:3.4.25.1) hsa:5696 PSMB8; proteasome (prosome, macropain) subunit, beta type, 8 (EC:3.4.25.1) hsa:5702 PSMC3; proteasome (prosome, macropain) 26S subunit, ATPase, 3 hsa:5720 PSME1; proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)

hsa04973 Carbohydrate digestion and absorption - Homo sapiens (human) (6)

cpd:C00011 CO2 cpd:C00033 Acetate cpd:C00246 Butanoic acid hsa:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha) hsa:5330 PLCB2; phospholipase C, beta 2 (EC:3.1.4.11)

hsa05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) - Homo sapiens (human) (6)

hsa:1499 CTNNB1; catenin (cadherin-associated protein), beta 1, 88kDa hsa:3673 ITGA2; integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) hsa:3678 ITGA5; integrin, alpha 5 (fibronectin receptor, alpha polypeptide) hsa:3688 ITGB1; integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) hsa:3691 ITGB4; integrin, beta 4 hsa:51176 LEF1; lymphoid enhancer-binding factor 1

hsa00270 Cysteine and methionine metabolism - Homo sapiens (human) (6)

cpd:C00051 Glutathione cpd:C00155 L-Homocysteine hsa:262 AMD1; adenosylmethionine decarboxylase 1 (EC:4.1.1.50) hsa:1789 DNMT3B; DNA (cytosine-5-)-methyltransferase 3 beta (EC:2.1.1.37) hsa:3945 LDHB; lactate dehydrogenase B (EC:1.1.1.27) hsa:6611 SMS; spermine synthase (EC:2.5.1.22)

hsa00910 Nitrogen metabolism - Homo sapiens (human) (6)

cpd:C00011 CO2 cpd:C00014 Ammonia cpd:C00025 L-Glutamate cpd:C00064 L-Glutamine cpd:C00533 Nitric oxide hsa:760 CA2; carbonic anhydrase II (EC:4.2.1.1)

hsa00970 Aminoacyl-tRNA biosynthesis - Homo sapiens (human) (6)

cpd:C00025 L-Glutamate cpd:C00062 L-Arginine cpd:C00064 L-Glutamine cpd:C00078 L-Tryptophan cpd:C00082 L-Tyrosine hsa:833 CARS; cysteinyl-tRNA synthetase (EC:6.1.1.16)

hsa00520 Amino sugar and nucleotide sugar metabolism - Homo sapiens (human) (6)

hsa:51700 CYB5R2; cytochrome b5 reductase 2 (EC:1.6.2.2) hsa:9945 GFPT2; glutamine-fructose-6-phosphate transaminase 2 (EC:2.6.1.16) hsa:2821 GPI; glucose-6-phosphate isomerase (EC:5.3.1.9) hsa:3074 HEXB; hexosaminidase B (beta polypeptide) (EC:3.2.1.52) hsa:54187 NANS; N-acetylneuraminic acid synthase (EC:2.5.1.56 2.5.1.57) hsa:55276 PGM2; phosphoglucomutase 2 (EC:5.4.2.2 5.4.2.7)

hsa00600 Sphingolipid metabolism - Homo sapiens (human) (6)

cpd:C00195 N-Acylsphingosine cpd:C00550 Sphingomyelin hsa:9331 B4GALT6; UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6 (EC:2.4.1.274) hsa:8613 PPAP2B; phosphatidic acid phosphatase type 2B (EC:3.1.3.4) hsa:130367 SGPP2; sphingosine-1-phosphate phosphatase 2 hsa:7368 UGT8; UDP glycosyltransferase 8 (EC:2.4.1.45)

hsa04330 Notch signaling pathway - Homo sapiens (human) (6)

hsa:6868 ADAM17; ADAM metallopeptidase domain 17 (EC:3.4.24.86) hsa:1856 DVL2; dishevelled segment polarity protein 2 hsa:1857 DVL3; dishevelled segment polarity protein 3 hsa:182 JAG1; jagged 1 hsa:4853 NOTCH2; notch 2 hsa:5663 PSEN1; presenilin 1 (EC:3.4.23.-)

hsa00250 Alanine, aspartate and glutamate metabolism - Homo sapiens (human) (6)

cpd:C00014 Ammonia cpd:C00025 L-Glutamate cpd:C00064 L-Glutamine hsa:440 ASNS; asparagine synthetase (glutamine-hydrolyzing) (EC:6.3.5.4) hsa:790 CAD; carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase (EC:2.1.3.2 3.5.2.3 6.3.5.5) hsa:9945 GFPT2; glutamine-fructose-6-phosphate transaminase 2 (EC:2.6.1.16)

hsa04961 Endocrine and other factor-regulated calcium reabsorption - Homo sapiens (human) (6)

cpd:C00951 Estradiol-17beta hsa:115 ADCY9; adenylate cyclase 9 (EC:4.6.1.1) hsa:2778 GNAS; GNAS complex locus hsa:5330 PLCB2; phospholipase C, beta 2 (EC:3.1.4.11) hsa:5332 PLCB4; phospholipase C, beta 4 (EC:3.1.4.11) hsa:5578 PRKCA; protein kinase C, alpha (EC:2.7.11.13)

hsa00340 Histidine metabolism - Homo sapiens (human) (5)

cpd:C00025 L-Glutamate cpd:C00388 Histamine hsa:1644 DDC; dopa decarboxylase (aromatic L-amino acid decarboxylase) (EC:4.1.1.28) hsa:3067 HDC; histidine decarboxylase (EC:4.1.1.22) hsa:4128 MAOA; monoamine oxidase A (EC:1.4.3.4)

hsa03420 Nucleotide excision repair - Homo sapiens (human) (5)

hsa:2067 ERCC1; excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence) hsa:2068 ERCC2; excision repair cross-complementing rodent repair deficiency, complementation group 2 (EC:3.6.4.12) hsa:5111 PCNA; proliferating cell nuclear antigen hsa:5886 RAD23A; RAD23 homolog A (S. cerevisiae) hsa:5983 RFC3; replication factor C (activator 1) 3, 38kDa

hsa00983 Drug metabolism - other enzymes - Homo sapiens (human) (5)

ec:3.1.1.1 carboxylesterase; ali-esterase; B-esterase; monobutyrase; cocaine esterase; procaine esterase; methylbutyrase; vitamin A esterase; butyryl esterase; carboxyesterase; carboxylate esterase; carboxylic esterase; methylbutyrate esterase; triacetin esterase; carboxyl ester hydrolase; butyrate esterase; methylbutyrase; alpha-carboxylesterase; propionyl esterase; nonspecific carboxylesterase; esterase D; esterase B; esterase A; serine esterase; carboxylic acid esterase; cocaine esterase hsa:3615 IMPDH2; IMP (inosine 5'-monophosphate) dehydrogenase 2 (EC:1.1.1.205) hsa:54658 UGT1A1; UDP glucuronosyltransferase 1 family, polypeptide A1 (EC:2.4.1.17) hsa:7378 UPP1; uridine phosphorylase 1 (EC:2.4.2.3)

hsa03018 RNA degradation - Homo sapiens (human) (5)

hsa:2023 ENO1; enolase 1, (alpha) (EC:4.2.1.11) hsa:2027 ENO3; enolase 3 (beta, muscle) (EC:4.2.1.11) hsa:3329 HSPD1; heat shock 60kDa protein 1 (chaperonin) hsa:25804 LSM4; LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae) hsa:26986 PABPC1; poly(A) binding protein, cytoplasmic 1

hsa04962 Vasopressin-regulated water reabsorption - Homo sapiens (human) (5)

hsa:115 ADCY9; adenylate cyclase 9 (EC:4.6.1.1) hsa:361 AQP4; aquaporin 4 hsa:1385 CREB1; cAMP responsive element binding protein 1 hsa:9586 CREB5; cAMP responsive element binding protein 5 hsa:2778 GNAS; GNAS complex locus

hsa00620 Pyruvate metabolism - Homo sapiens (human) (5)

cpd:C00033 Acetate cpd:C00084 Acetaldehyde hsa:1738 DLD; dihydrolipoamide dehydrogenase (EC:1.8.1.4) hsa:3945 LDHB; lactate dehydrogenase B (EC:1.1.1.27) hsa:5106 PCK2; phosphoenolpyruvate carboxykinase 2 (mitochondrial) (EC:4.1.1.32)

hsa03410 Base excision repair - Homo sapiens (human) (5)

hsa:328 APEX1; APEX nuclease (multifunctional DNA repair enzyme) 1 (EC:4.2.99.18) hsa:3146 HMGB1; high mobility group box 1 hsa:4968 OGG1; 8-oxoguanine DNA glycosylase (EC:4.2.99.18) hsa:142 PARP1; poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) hsa:5111 PCNA; proliferating cell nuclear antigen

hsa04614 Renin-angiotensin system - Homo sapiens (human) (4)

hsa:1636 ACE; angiotensin I converting enzyme (EC:3.4.15.1) hsa:185 AGTR1; angiotensin II receptor, type 1 hsa:186 AGTR2; angiotensin II receptor, type 2 hsa:1215 CMA1; chymase 1, mast cell (EC:3.4.21.39)

hsa00460 Cyanoamino acid metabolism - Homo sapiens (human) (4)

cpd:C00011 CO2 cpd:C00014 Ammonia cpd:C00082 L-Tyrosine hsa:2678 GGT1; gamma-glutamyltransferase 1 (EC:2.3.2.2 3.4.19.13 3.4.19.14)

hsa00360 Phenylalanine metabolism - Homo sapiens (human) (4)

cpd:C00082 L-Tyrosine cpd:C00084 Acetaldehyde hsa:1644 DDC; dopa decarboxylase (aromatic L-amino acid decarboxylase) (EC:4.1.1.28) hsa:4128 MAOA; monoamine oxidase A (EC:1.4.3.4)

hsa03010 Ribosome - Homo sapiens (human) (4)

hsa:51318 MRPL35; mitochondrial ribosomal protein L35 hsa:6158 RPL28; ribosomal protein L28 (EC:3.6.5.3) hsa:6169 RPL38; ribosomal protein L38 hsa:6128 RPL6; ribosomal protein L6

hsa01210 2-Oxocarboxylic acid metabolism - Homo sapiens (human) (4)

cpd:C00025 L-Glutamate cpd:C00077 L-Ornithine cpd:C00078 L-Tryptophan cpd:C00082 L-Tyrosine

hsa03450 Non-homologous end-joining - Homo sapiens (human) (4)

hsa:4361 MRE11A; MRE11 meiotic recombination 11 homolog A (S. cerevisiae) hsa:27434 POLM; polymerase (DNA directed), mu (EC:2.7.7.7) hsa:7518 XRCC4; X-ray repair complementing defective repair in Chinese hamster cells 4 hsa:2547 XRCC6; X-ray repair complementing defective repair in Chinese hamster cells 6

hsa00062 Fatty acid elongation - Homo sapiens (human) (4)

hsa:10965 ACOT2; acyl-CoA thioesterase 2 (EC:3.1.2.2) hsa:79071 ELOVL6; ELOVL fatty acid elongase 6 (EC:2.3.1.199) hsa:3030 HADHA; hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit (EC:4.2.1.17 1.1.1.211) hsa:9524 TECR; trans-2,3-enoyl-CoA reductase (EC:1.3.1.93)

hsa04975 Fat digestion and absorption - Homo sapiens (human) (4)

cpd:C00187 Cholesterol hsa:335 APOA1; apolipoprotein A-I hsa:948 CD36; CD36 molecule (thrombospondin receptor) hsa:8613 PPAP2B; phosphatidic acid phosphatase type 2B (EC:3.1.3.4)

hsa00591 Linoleic acid metabolism - Homo sapiens (human) (4)

ec:3.1.1.32 phospholipase A1 hsa:1544 CYP1A2; cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) hsa:1557 CYP2C19; cytochrome P450, family 2, subfamily C, polypeptide 19 (EC:1.14.13.48 1.14.13.49 1.14.13.80) hsa:1573 CYP2J2; cytochrome P450, family 2, subfamily J, polypeptide 2 (EC:1.14.14.1)

hsa04742 Taste transduction - Homo sapiens (human) (4)

cpd:C00025 L-Glutamate cpd:C00080 H+ hsa:2778 GNAS; GNAS complex locus hsa:5330 PLCB2; phospholipase C, beta 2 (EC:3.1.4.11)

hsa00565 Ether lipid metabolism - Homo sapiens (human) (4)

cpd:C04598 2-Acetyl-1-alkyl-sn-glycero-3-phosphocholine ec:3.1.1.32 phospholipase A1 hsa:5337 PLD1; phospholipase D1, phosphatidylcholine-specific (EC:3.1.4.4) hsa:8613 PPAP2B; phosphatidic acid phosphatase type 2B (EC:3.1.3.4)

hsa00531 Glycosaminoglycan degradation - Homo sapiens (human) (4)

cpd:C00426 Dermatan sulfate cpd:C00925 Heparan sulfate hsa:3074 HEXB; hexosaminidase B (beta polypeptide) (EC:3.2.1.52) hsa:3423 IDS; iduronate 2-sulfatase (EC:3.1.6.13)

hsa03008 Ribosome biogenesis in eukaryotes - Homo sapiens (human) (4)

hsa:1457 CSNK2A1; casein kinase 2, alpha 1 polypeptide (EC:2.7.11.1) hsa:1736 DKC1; dyskeratosis congenita 1, dyskerin hsa:3692 EIF6; eukaryotic translation initiation factor 6 (EC:3.6.5.3) hsa:23560 GTPBP4; GTP binding protein 4

hsa04740 Olfactory transduction - Homo sapiens (human) (4)

cpd:C00698 Cl- hsa:8390 OR1G1; olfactory receptor, family 1, subfamily G, member 1 hsa:81285 OR51E2; olfactory receptor, family 51, subfamily E, member 2 hsa:5132 PDC; phosducin

hsa00030 Pentose phosphate pathway - Homo sapiens (human) (4)

hsa:226 ALDOA; aldolase A, fructose-bisphosphate (EC:4.1.2.13) hsa:230 ALDOC; aldolase C, fructose-bisphosphate (EC:4.1.2.13) hsa:2821 GPI; glucose-6-phosphate isomerase (EC:5.3.1.9) hsa:55276 PGM2; phosphoglucomutase 2 (EC:5.4.2.2 5.4.2.7)

hsa03013 RNA transport - Homo sapiens (human) (4)

hsa:22985 ACIN1; apoptotic chromatin condensation inducer 1 hsa:1915 EEF1A1; eukaryotic translation elongation factor 1 alpha 1 hsa:26986 PABPC1; poly(A) binding protein, cytoplasmic 1 hsa:6396 SEC13; SEC13 homolog (S. cerevisiae)

hsa01040 Biosynthesis of unsaturated fatty acids - Homo sapiens (human) (4)

hsa01220 Degradation of aromatic compounds - Homo sapiens (human) (4)

cpd:C00033 Acetate cpd:C00084 Acetaldehyde cpd:C00261 Benzaldehyde cpd:C00556 Benzyl alcohol

hsa00514 Other types of O-glycan biosynthesis - Homo sapiens (human) (4)

hsa:9486 CHST10; carbohydrate sulfotransferase 10 hsa:2526 FUT4; fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific) (EC:2.4.1.-) hsa:2529 FUT7; fucosyltransferase 7 (alpha (1,3) fucosyltransferase) (EC:2.4.1.-) hsa:6480 ST6GAL1; ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 (EC:2.4.99.1)

hsa03015 mRNA surveillance pathway - Homo sapiens (human) (4)

hsa:22985 ACIN1; apoptotic chromatin condensation inducer 1 hsa:29894 CPSF1; cleavage and polyadenylation specific factor 1, 160kDa hsa:26986 PABPC1; poly(A) binding protein, cytoplasmic 1 hsa:8731 RNMT; RNA (guanine-7-) methyltransferase (EC:2.1.1.56)

hsa04260 Cardiac muscle contraction - Homo sapiens (human) (4)

cpd:C00080 H+ hsa:70 ACTC1; actin, alpha, cardiac muscle 1 hsa:4512 COX1; cytochrome c oxidase subunit I hsa:7169 TPM2; tropomyosin 2 (beta)

hsa00410 beta-Alanine metabolism - Homo sapiens (human) (4)

cpd:C00315 Spermidine cpd:C00750 Spermine hsa:3030 HADHA; hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit (EC:4.2.1.17 1.1.1.211) hsa:6611 SMS; spermine synthase (EC:2.5.1.22)

hsa00280 Valine, leucine and isoleucine degradation - Homo sapiens (human) (3)

hsa:594 BCKDHB; branched chain keto acid dehydrogenase E1, beta polypeptide (EC:1.2.4.4) hsa:1738 DLD; dihydrolipoamide dehydrogenase (EC:1.8.1.4) hsa:3030 HADHA; hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit (EC:4.2.1.17 1.1.1.211)

hsa03022 Basal transcription factors - Homo sapiens (human) (3)

hsa:2068 ERCC2; excision repair cross-complementing rodent repair deficiency, complementation group 2 (EC:3.6.4.12) hsa:6884 TAF13; TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa hsa:54457 TAF7L; TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa

hsa00071 Fatty acid degradation - Homo sapiens (human) (3)

cpd:C00071 Aldehyde hsa:131 ADH7; alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide (EC:1.1.1.1) hsa:3030 HADHA; hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit (EC:4.2.1.17 1.1.1.211)

hsa00500 Starch and sucrose metabolism - Homo sapiens (human) (3)

hsa:2821 GPI; glucose-6-phosphate isomerase (EC:5.3.1.9) hsa:55276 PGM2; phosphoglucomutase 2 (EC:5.4.2.2 5.4.2.7) hsa:54658 UGT1A1; UDP glucuronosyltransferase 1 family, polypeptide A1 (EC:2.4.1.17)

hsa00130 Ubiquinone and other terpenoid-quinone biosynthesis - Homo sapiens (human) (3)

cpd:C00082 L-Tyrosine cpd:C02477 alpha-Tocopherol hsa:1728 NQO1; NAD(P)H dehydrogenase, quinone 1 (EC:1.6.5.2)

hsa00430 Taurine and hypotaurine metabolism - Homo sapiens (human) (3)

cpd:C00025 L-Glutamate cpd:C00033 Acetate hsa:2678 GGT1; gamma-glutamyltransferase 1 (EC:2.3.2.2 3.4.19.13 3.4.19.14)

hsa00650 Butanoate metabolism - Homo sapiens (human) (3)

cpd:C00025 L-Glutamate cpd:C00246 Butanoic acid hsa:3030 HADHA; hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit (EC:4.2.1.17 1.1.1.211)

hsa00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin - Homo sapiens (human) (3)

cpd:C00033 Acetate hsa:9957 HS3ST1; heparan sulfate (glucosamine) 3-O-sulfotransferase 1 (EC:2.8.2.23) hsa:9956 HS3ST2; heparan sulfate (glucosamine) 3-O-sulfotransferase 2 (EC:2.8.2.29)

hsa00640 Propanoate metabolism - Homo sapiens (human) (3)

cpd:C00207 Acetone hsa:3030 HADHA; hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit (EC:4.2.1.17 1.1.1.211) hsa:3945 LDHB; lactate dehydrogenase B (EC:1.1.1.27)

hsa00760 Nicotinate and nicotinamide metabolism - Homo sapiens (human) (3)

cpd:C00006 NADP+ hsa:4860 PNP; purine nucleoside phosphorylase (EC:2.4.2.1) hsa:23475 QPRT; quinolinate phosphoribosyltransferase (EC:2.4.2.19)

hsa03430 Mismatch repair - Homo sapiens (human) (3)

hsa:4292 MLH1; mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) hsa:5111 PCNA; proliferating cell nuclear antigen hsa:5983 RFC3; replication factor C (activator 1) 3, 38kDa

hsa03460 Fanconi anemia pathway - Homo sapiens (human) (3)

hsa:672 BRCA1; breast cancer 1, early onset hsa:2067 ERCC1; excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence) hsa:4292 MLH1; mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli)

hsa00051 Fructose and mannose metabolism - Homo sapiens (human) (3)

hsa:226 ALDOA; aldolase A, fructose-bisphosphate (EC:4.1.2.13) hsa:230 ALDOC; aldolase C, fructose-bisphosphate (EC:4.1.2.13) hsa:7167 TPI1; triosephosphate isomerase 1 (EC:5.3.1.1)

hsa00511 Other glycan degradation - Homo sapiens (human) (3)

hsa:175 AGA; aspartylglucosaminidase (EC:3.5.1.26) hsa:2519 FUCA2; fucosidase, alpha-L- 2, plasma (EC:3.2.1.51) hsa:3074 HEXB; hexosaminidase B (beta polypeptide) (EC:3.2.1.52)

hsa00920 Sulfur metabolism - Homo sapiens (human) (3)

cpd:C00033 Acetate cpd:C00155 L-Homocysteine hsa:54205 CYCS; cytochrome c, somatic

hsa00120 Primary bile acid biosynthesis - Homo sapiens (human) (3)

cpd:C00187 Cholesterol hsa:8309 ACOX2; acyl-CoA oxidase 2, branched chain (EC:1.17.99.3) hsa:23600 AMACR; alpha-methylacyl-CoA racemase (EC:5.1.99.4)

hsa00472 D-Arginine and D-ornithine metabolism - Homo sapiens (human) (2)

cpd:C00062 L-Arginine cpd:C00077 L-Ornithine

hsa00400 Phenylalanine, tyrosine and tryptophan biosynthesis - Homo sapiens (human) (2)

cpd:C00078 L-Tryptophan cpd:C00082 L-Tyrosine

hsa03060 Protein export - Homo sapiens (human) (2)

hsa:3309 HSPA5; heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) hsa:6730 SRP68; signal recognition particle 68kDa

hsa00040 Pentose and glucuronate interconversions - Homo sapiens (human) (2)

hsa:51181 DCXR; dicarbonyl/L-xylulose reductase (EC:1.1.1.10) hsa:54658 UGT1A1; UDP glucuronosyltransferase 1 family, polypeptide A1 (EC:2.4.1.17)

hsa04710 Circadian rhythm - Homo sapiens (human) (2)

hsa:406 ARNTL; aryl hydrocarbon receptor nuclear translocator-like hsa:1385 CREB1; cAMP responsive element binding protein 1

hsa00603 Glycosphingolipid biosynthesis - globo series - Homo sapiens (human) (2)

hsa:2524 FUT2; fucosyltransferase 2 (secretor status included) (EC:2.4.1.69) hsa:3074 HEXB; hexosaminidase B (beta polypeptide) (EC:3.2.1.52)

hsa00053 Ascorbate and aldarate metabolism - Homo sapiens (human) (2)

cpd:C00072 Ascorbate hsa:54658 UGT1A1; UDP glucuronosyltransferase 1 family, polypeptide A1 (EC:2.4.1.17)

hsa00100 Steroid biosynthesis - Homo sapiens (human) (2)

cpd:C00187 Cholesterol hsa:50814 NSDHL; NAD(P) dependent steroid dehydrogenase-like (EC:1.1.1.170)

hsa00750 Vitamin B6 metabolism - Homo sapiens (human) (2)

cpd:C00018 Pyridoxal phosphate hsa:29968 PSAT1; phosphoserine aminotransferase 1 (EC:2.6.1.52)

hsa03030 DNA replication - Homo sapiens (human) (2)

hsa:5111 PCNA; proliferating cell nuclear antigen hsa:5983 RFC3; replication factor C (activator 1) 3, 38kDa

hsa04744 Phototransduction - Homo sapiens (human) (2)

hsa:408 ARRB1; arrestin, beta 1 hsa:8787 RGS9; regulator of G-protein signaling 9

hsa00604 Glycosphingolipid biosynthesis - ganglio series - Homo sapiens (human) (2)

hsa:3074 HEXB; hexosaminidase B (beta polypeptide) (EC:3.2.1.52) hsa:9197 SLC33A1; solute carrier family 33 (acetyl-CoA transporter), member 1

hsa00563 Glycosylphosphatidylinositol(GPI)-anchor biosynthesis - Homo sapiens (human) (2)

hsa:5277 PIGA; phosphatidylinositol glycan anchor biosynthesis, class A (EC:2.4.1.198) hsa:55650 PIGV; phosphatidylinositol glycan anchor biosynthesis, class V

hsa00471 D-Glutamine and D-glutamate metabolism - Homo sapiens (human) (2)

cpd:C00025 L-Glutamate cpd:C00064 L-Glutamine

hsa00561 Glycerolipid metabolism - Homo sapiens (human) (2)

hsa:9388 LIPG; lipase, endothelial (EC:3.1.1.3) hsa:8613 PPAP2B; phosphatidic acid phosphatase type 2B (EC:3.1.3.4)

hsa00592 alpha-Linolenic acid metabolism - Homo sapiens (human) (1)

ec:3.1.1.32 phospholipase A1

hsa00670 One carbon pool by folate - Homo sapiens (human) (1)

hsa:4524 MTHFR; methylenetetrahydrofolate reductase (NAD(P)H) (EC:1.5.1.20)

hsa00740 Riboflavin metabolism - Homo sapiens (human) (1)

cpd:C00007 Oxygen

hsa00900 Terpenoid backbone biosynthesis - Homo sapiens (human) (1)

hsa:57107 PDSS2; prenyl (decaprenyl) diphosphate synthase, subunit 2 (EC:2.5.1.91)

hsa00532 Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate - Homo sapiens (human) (1)

hsa:10090 UST; uronyl-2-sulfotransferase

hsa00730 Thiamine metabolism - Homo sapiens (human) (1)

cpd:C00082 L-Tyrosine

hsa00524 Butirosin and neomycin biosynthesis - Homo sapiens (human) (1)

cpd:C00025 L-Glutamate

hsa00310 Lysine degradation - Homo sapiens (human) (1)

hsa:3030 HADHA; hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit (EC:4.2.1.17 1.1.1.211)

hsa00533 Glycosaminoglycan biosynthesis - keratan sulfate - Homo sapiens (human) (1)

hsa:11041 B3GNT1; UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1 (EC:2.4.1.149)

hsa03440 Homologous recombination - Homo sapiens (human) (1)

hsa:4361 MRE11A; MRE11 meiotic recombination 11 homolog A (S. cerevisiae)

hsa00780 Biotin metabolism - Homo sapiens (human) (1)

cpd:C00086 Urea

hsa00052 Galactose metabolism - Homo sapiens (human) (1)

hsa:55276 PGM2; phosphoglucomutase 2 (EC:5.4.2.2 5.4.2.7)

hsa00770 Pantothenate and CoA biosynthesis - Homo sapiens (human) (1)

hsa:60496 AASDHPPT; aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase (EC:2.7.8.-)

hsa00510 N-Glycan biosynthesis - Homo sapiens (human) (1)

hsa:6480 ST6GAL1; ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 (EC:2.4.99.1)

hsa00512 Mucin type O-Glycan biosynthesis - Homo sapiens (human) (1)

hsa:55808 ST6GALNAC1; ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 (EC:2.4.99.3)

hsa03020 RNA polymerase - Homo sapiens (human) (1)

hsa:10621 POLR3F; polymerase (RNA) III (DNA directed) polypeptide F, 39 kDa

hsa00072 Synthesis and degradation of ketone bodies - Homo sapiens (human) (1)

cpd:C00207 Acetone

hsa00232 Caffeine metabolism - Homo sapiens (human) (1)

hsa:1544 CYP1A2; cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1)

Pathway Search Result

Host genes involved in the H.Pylori/host interactome: Yellow = genes: Red = compounds involved in the bacterial life cycle: Click on "show all objects for gene and compound details.