LSS
3-OH-3
methylglutaryl-CoA
Mevalonate
Mevalonate-5P
Mevalonate5PP
Isopentenyl-PP
Farnesyl
PP
Presqualene-PP
24S-OH
C
PMVK
AcAcCoA
AcCoA
SOAT1
LRP8
ABCA2
MVK
MVD
FDFT1
FDFT1
ACAT
HMGCR
HMGCS2
FDPS
APOE
SREBF1
Presqualene-PP
Squalene
Squalene-2,3epoxide
Lanosterol
Dimethylallyl
PP
GeranylPP
IDI1
Lathosterol
7Dehydrocholesterol
Cholesterol
DHCR7
AcCoA
+ Acetoacatate
ABCA1
Cholesterol
4-b
OH C
25-
OH C
7-B-OHC
CYP46A1
CH25H
CYP3A4
APP
LRP6
LRP1
APOA1
APOA4
APOC1/C2/C3
VLDLR
LDLR
Fatty
acid metabolism
Zymosterol
Desmosterol
EBP
DHCR24
GGPS1
FDPS
HMGCL
APOD
LPA
SC5DL
EBP
SQLE
CYP51
HSD11B1
NR1H2
Liver
X receptor
ABCG1
Cholesterol
transporters
SORL1
CD36
CETP
APP
Lipoproteins
Receptors
OLR1
NPC2
OPRS1
PPARA
PPARG
LRPAP1
A2M
LIPA
LPL
POU2F1
NR1H2
AD genes
AD and
Atherosclerosis
CLU
LRP1B
APOA5
APOC5
NPC1
LRP2
LIPA
MAPK8IP1
DAB1
APBB1
APBB3
APBB2
