Polygenic Pathways

Polygenic pathways

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Host pathogen interactomes for :Bornavirus; Borrelia Burgdorferi; Candida albicans; Chlamydia Pneumoniae ; Cryptococcus Neoformans; Ebola virus; Epstein-Barr virus; Helicobacter pylori; Hepatitis C virus; Herpes simplex (HSV-1); HERV-W; HIV-1, Human Protein Interaction Database (NCBI); Human cytomegalovirus; Influenza A virus; Porphyromonas Gingivalis; Toxoplasma Gondii; Trypanosoma Cruzi : KEGG pathway analysis of these interactomes can be accessed here

Alzheimer's disease



Attention deficit hyperactivity disorder (ADHD)

ADHD genes and risk factors ADHD genes KEGG pathways

Anorexia nervosa

Anorexia genes and risk factors Anorexia genes Kegg pathways


KEGG pathway analysis of Autism susceptibility genes

Bipolar disorder

Childhood obesity

Childhood obesity genes and risk factors Kegg pathway analysis of childhood obesity genes

Chronic fatigue syndrome

Chronic fatigue genes and risk factors Chronic fatigue genes: KEGG pathways

Cystic fibrosis

CFTR interactome KEGG pathway analysis

CFTR homologies with S.aureus, P.aeruginosa and S.maltophilia proteins and with cystic fibrosis autoantigens


Unipolar depresssion genes and risk factors KEGG pathways of depression susceptibility genes

Huntington's disease

KEGG pathways traced out by the Huntington's disease HTT Huntingtin interactome  

Multiple sclerosis

KEGG pathway analysis of multiple sclerosis susceptibility genes

Autoantigen homology with viral risk factors MBP,MOG and CLDN11 CRYAB, CNP,MAG, EIF2B5

Parkinson's disease

KEGG pathway analysis of Parkinson's disease genes



The microbiome and probiotics in health and disease

  • Viruses, bacteria and other pathogens have been implicated in many human diseases including Alzheimer's and atherosclerosis, autism , depression, bipolar disorder, schizophrenia, type 1 diabetes, irritable bowel syndrome, multiple sclerosis and Parkinson's disease, and many others, and can cause numerous cancers.In some cases there are "good viruses or bacteria" and characterisation of the microbiome in health and disease by the Human microbiome project is helping to define these. Some have already been used to good effect and the use of probiotics or even helminth infection as therapy is a burgeoning field.
  • Some of the pathogens implicated are listed here

Other KEGG Signalling networks from GWAS and other studies and Interactomes

Useful links

Viral integration into the human genome See this set of papers and Trost et al, 2011 and Nature precedings

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Throughout this site there are links to Entrez Gene and Pubmed (a service of the National Library of Medicine that includes over 16 million citations from MEDLINE a nd other life science journals for biomedical articles back to the 1950s. PubMed includes links to full text articles and other related resources) See disclaimer and copyright, as well as to OMIM(Online Mendelian Inheritance in Man, OMIM (TM). McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University (Baltimore, MD) and National Center for Biotechnology Information, National Library of Medicine (Bethesda, MD). Genecards data are with the permission of GeneCards.org. BIOCARTA pathway links are provided for some genes (see Terms and conditions) and Disclaimer. BioGrid links are from the Ontario Cancer Institute, Canada Stark et al, 2006.

Authored by Chris Carter: B.Sc (Zoology), M.Sc (Pharmacology), Ph.D (Pharmacology) Google Scholar ...........LinkedIn Profile Email:

Last modified October 21, 2016